RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Cardiotoxicity
Accession: DOID:9002371
browse the term
Definition: Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.
Synonyms: exact_synonym: Cardiac Toxicities; Cardiac Toxicity; Cardiotoxicities
primary_id: MESH:D066126
xref: EFO:1001482
G
Acacb
acetyl-CoA carboxylase beta
IEP
mRNA, protein:increased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
G
Agt
angiotensinogen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33676887
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
G
Bche
butyrylcholinesterase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:26145887
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
G
Bmp2
bone morphogenetic protein 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29800642
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
G
Cat
catalase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:35792220
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccl2
C-C motif chemokine ligand 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Cpt1a
carnitine palmitoyltransferase 1A
IEP
mRNA, protein:decreased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
G
Csf1
colony stimulating factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32068018
NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
G
Fas
Fas cell surface death receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34713381
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Faslg
Fas ligand
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34713381
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
G
Fto
FTO, alpha-ketoglutarate dependent dioxygenase
IDA
DNA:hypermethylation:promoter
RGD
PMID:35462195
RGD:329951017
NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083
G
Hbegf
heparin-binding EGF-like growth factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29305325
NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
G
Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32068018
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Kcnn2
potassium calcium-activated channel subfamily N member 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:32909839 PMID:33887967
NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
G
Mettl14
methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34648132
NCBI chr 2:211,530,598...211,546,845
Ensembl chr 2:211,530,602...211,546,821
G
Mir143
microRNA 143
ameliorates
ISO
RGD
PMID:32170053
RGD:155883163
NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110
G
Mir208a
microRNA 208a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26454886
NCBI chr15:28,425,570...28,425,652
G
Mlycd
malonyl-CoA decarboxylase
IEP
protein:increased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793
G
Nos3
nitric oxide synthase 3
treatment
ISO
associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma;DNA:polymorphism: :894G>T(human)
RGD
PMID:26345518
RGD:11533645
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
G
Nppb
natriuretic peptide B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
G
Nrg1
neuregulin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29305325
NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
G
Prkaa2
protein kinase AMP-activated catalytic subunit alpha 2
IEP
protein:decreased expression:serum, heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
G
Rac1
Rac family small GTPase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28710503
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
G
Rarg
retinoic acid receptor, gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26237429
NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
G
Rnf10
ring finger protein 10
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:36740146
NCBI chr12:41,341,708...41,375,505
Ensembl chr12:41,341,717...41,375,504
G
Sirt6
sirtuin 6
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:34713381
NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
G
Tlr2
toll-like receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
G
Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987 PMID:32068018
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30009776 PMID:34713381
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Abcb1a
ATP binding cassette subfamily B member 1A
susceptibility
ISO
DNA:missense mutation:cds:p.G671V (human)
RGD
PMID:16330681
RGD:11041175
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Acvr2b
activin A receptor type 2B
treatment
ISO
human construct in mouse model
RGD
PMID:30765322
RGD:329849112
NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458
G
Capn2
calpain 2
treatment
IEP
RGD
PMID:25634181
RGD:13792617
NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
G
Ercc2
ERCC excision repair 2, TFIIH core complex helicase subunit
ISO
associated with Leukemia, Myeloid, Acute;DNA:SNP:exon:p.K751Q (rs13181) (human)
RGD
PMID:24284041
RGD:11252190
NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all