Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Cardiotoxicity
go back to main search page
Accession:DOID:9002371 term browser browse the term
Definition:Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.
Synonyms:exact_synonym: Cardiac Toxicities;   Cardiac Toxicity;   Cardiotoxicities
 primary_id: MESH:D066126
 xref: EFO:1001482

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
Cardiotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACACB acetyl-CoA carboxylase beta ISO mRNA, protein:increased expression:heart (rat) RGD PMID:30644033 RGD:329955369 NCBI chr11:104,325,250...104,488,567
Ensembl chr11:104,349,573...104,488,003 		JBrowse link
G AGT angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:33676887 NCBI chr25:67,964,840...67,977,006
Ensembl chr25:67,962,401...67,973,324 		JBrowse link
G BCHE butyrylcholinesterase ISO CTD Direct Evidence: therapeutic CTD PMID:26145887 NCBI chr15:23,708,121...23,778,027
Ensembl chr15:23,708,155...23,778,286 		JBrowse link
G BMP2 bone morphogenetic protein 2 ISO CTD Direct Evidence: therapeutic CTD PMID:29800642 NCBI chr 2:31,349,394...31,361,227
Ensembl chr 2:31,348,808...31,360,901 		JBrowse link
G CAT catalase ISO CTD Direct Evidence: therapeutic CTD PMID:35792220 NCBI chr 1:30,792,533...30,828,920
Ensembl chr 1:30,792,399...30,829,592 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 NCBI chr16:27,763,354...27,765,437
Ensembl chr16:27,763,555...27,765,416 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A ISO mRNA, protein:decreased expression:heart (rat) RGD PMID:30644033 RGD:329955369 NCBI chr 1:5,704,275...5,784,077
Ensembl chr 1:5,730,853...5,784,337 		JBrowse link
G CSF1 colony stimulating factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32068018 NCBI chr20:23,615,107...23,635,399 JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 NCBI chr 7:22,202,497...22,205,730
Ensembl chr 7:22,202,527...22,204,068 		JBrowse link
G FASLG Fas ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:34713381 NCBI chr25:56,488,572...56,496,469
Ensembl chr25:56,489,417...56,496,251 		JBrowse link
G FTO FTO alpha-ketoglutarate dependent dioxygenase ISO DNA:hypermethylation:promoter RGD PMID:35462195 RGD:329951017 NCBI chr 5:39,487,304...39,900,238
Ensembl chr 5:39,487,418...39,725,747 		JBrowse link
G HBEGF heparin binding EGF like growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:29305325 NCBI chr23:42,981,640...42,995,116
Ensembl chr23:42,981,640...42,994,995 		JBrowse link
G IL1B interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:32068018 NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729 		JBrowse link
G KCNN2 potassium calcium-activated channel subfamily N member 2 ISO CTD Direct Evidence: therapeutic CTD PMID:32909839 PMID:33887967 NCBI chr23:17,595,661...17,735,675
Ensembl chr23:17,598,177...17,735,669 		JBrowse link
G METTL14 methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:34648132 NCBI chr 7:66,169,080...66,195,324
Ensembl chr 7:66,168,855...66,194,121 		JBrowse link
G MLYCD malonyl-CoA decarboxylase ISO protein:increased expression:heart (rat) RGD PMID:30644033 RGD:329955369 NCBI chr 5:69,312,978...69,329,346
Ensembl chr 5:69,313,062...69,329,102 		JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma;DNA:polymorphism: :894G>T(human) RGD PMID:26345518 RGD:11533645 NCBI chr21:119,174,829...119,196,840 JBrowse link
G NPPB natriuretic peptide B ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 NCBI chr20:119,930,931...119,933,391
Ensembl chr20:119,932,021...119,933,197 		JBrowse link
G NRG1 neuregulin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:29305325 NCBI chr 8:29,745,984...30,862,140
Ensembl chr 8:30,635,803...30,856,487 		JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 ISO protein:decreased expression:serum, heart (rat) RGD PMID:30644033 RGD:329955369 NCBI chr20:76,258,063...76,319,512
Ensembl chr20:76,259,763...76,319,430 		JBrowse link
G RAC1 Rac family small GTPase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28710503 NCBI chr28:15,583,609...15,610,753
Ensembl chr28:15,583,516...15,610,328 		JBrowse link
G RARG retinoic acid receptor gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:26237429 NCBI chr11:49,319,104...49,340,725
Ensembl chr11:49,319,839...49,328,656 		JBrowse link
G RNF10 ring finger protein 10 ISO CTD Direct Evidence: therapeutic CTD PMID:36740146 NCBI chr11:115,888,359...115,930,790
Ensembl chr11:115,893,457...115,930,848 		JBrowse link
G SIRT6 sirtuin 6 ISO CTD Direct Evidence: therapeutic CTD PMID:34713381 NCBI chr 6:3,924,230...3,932,583
Ensembl chr 6:3,924,230...3,932,590 		JBrowse link
G TLR2 toll like receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 PMID:32068018
G TP53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30009776 PMID:34713381 NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223 		JBrowse link
Anthracycline-induced Cardiotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 susceptibility ISO DNA:missense mutation:cds:p.G671V (human) RGD PMID:16330681 RGD:11041175 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ACVR2B activin A receptor type 2B treatment ISO human construct in mouse model RGD PMID:30765322 RGD:329849112 NCBI chr15:923,222...962,438 JBrowse link
G CAPN2 calpain 2 treatment ISO RGD PMID:25634181 RGD:13792617 NCBI chr25:5,845,873...5,905,464
Ensembl chr25:5,846,298...5,905,402 		JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit ISO associated with Leukemia, Myeloid, Acute;DNA:SNP:exon:p.K751Q (rs13181) (human) RGD PMID:24284041 RGD:11252190 NCBI chr 6:38,804,296...38,823,229
Ensembl chr 6:38,801,423...38,823,073 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15388
    Wounds and Injuries 937
      Radiation Injuries 76
        Cardiotoxicity 31
          Anthracycline-induced Cardiotoxicity 4
paths to the root