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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Ovarian Granulosa Cell Tumor
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Accession:DOID:9002365 term browser browse the term
Definition:This is a granulosa-stromal cell tumor that arises from the ovary. It is characterized by the presence of granulosa cells that comprise at least ten percent of the cellular population. The granulosa cells are often found in a background that contains theca and fibrous cells. There are two major subtypes recognized, adult and juvenile granulosa cell tumor. Clinically, patients may present with an abdominal mass. Symptoms depend on the patient's age. The most important indicator of prognosis is tumor stage. Age over forty years at the time of the initial diagnosis, large tumor size, bilaterality, cellular atypia, and increased mitotic activity are factors indicating a potentially aggressive clinical course and relative poor prognosis.
Synonyms:primary_id: EFO:1000421
 xref: NCI:C6261



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Ovarian Granulosa Cell Tumor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gnai2 G protein subunit alpha i2 ISO ClinVar Annotator: match by term: Ovarian granulosa cell tumor ClinVar PMID:2116665 NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:108,288,401...108,308,979
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Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19141
    disease of anatomical entity 18453
      endocrine system disease 7037
        Endocrine Gland Neoplasms 2828
          Ovarian Neoplasms 754
            Ovarian Granulosa Cell Tumor 1
Path 2
Term Annotations click to browse term
  disease 19141
    disease of anatomical entity 18453
      Urogenital Diseases 5391
        Female Urogenital Diseases and Pregnancy Complications 2668
          Female Urogenital Diseases 2191
            female reproductive system disease 2188
              Adnexal Diseases 1076
                ovarian disease 1067
                  Ovarian Neoplasms 754
                    Ovarian Granulosa Cell Tumor 1
paths to the root