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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Tinnitus
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Accession:DOID:9001733 term browser browse the term
Definition:A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.
Synonyms:exact_synonym: Clicking Tinnitus;   Leudet Tinnitus;   Leudet's Tinnitus;   Noise Induced Tinnitus;   Objective Tinnitus;   Pulsatile Tinnitus;   Ringing Buzzing Tinnitus;   Spontaneous Oto Acoustic Emission Tinnitus;   Subjective Tinnitus;   Tensor Palatini Induced Tinnitus;   Tensor Tympani Induced Tinnitus;   Tinnitus of Vascular Origin;   Tinnitus, Leudets;   Vascular Origin Tinnitus
 primary_id: MESH:D014012



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Tinnitus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase treatment IMP RGD PMID:17221143 RGD:9588534 NCBI chr10:7,503,351...7,599,474
Ensembl chr10:6,999,819...7,092,835
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein IEP mRNA:decreased expression:auditory cortex: RGD PMID:18524887 RGD:8655535 NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Bdnf brain-derived neurotrophic factor severity IEP
ISO
mRNA:increased expression:cochlea: RGD PMID:18524887 PMID:22281446 RGD:8655535, RGD:8655556 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A IEP mRNA, protein:increased expression:Cochlear Nucleus RGD PMID:24092407 RGD:401940125 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Il4r interleukin 4 receptor ISO associated with Hearing Loss, Sudden;DNA:SNP: :p.Q576R (rs 180275) (human) RGD PMID:16280132 RGD:7829784 NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Tnf tumor necrosis factor IEP mRNA, protein:increased expression:Cochlear Nucleus RGD PMID:24092407 RGD:401940125 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19142
    sensory system disease 7373
      Hearing Disorders 849
        Tinnitus 6
          episodic ataxia type 3 0
Path 2
Term Annotations click to browse term
  disease 19142
    Pathological Conditions, Signs and Symptoms 13627
      Signs and Symptoms 11216
        Neurologic Manifestations 10451
          sensory system disease 7373
            Otorhinolaryngologic Diseases 1799
              auditory system disease 1065
                Hearing Disorders 849
                  Tinnitus 6
                    episodic ataxia type 3 0
paths to the root