Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Retina Reperfusion Injury
go back to main search page
Accession:DOID:9001725 term browser browse the term
Definition:Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the retina, including swelling; hemorrhage; necrosis; and damage from free radicals.
Synonyms:exact_synonym: RIRI;   Retinal Ischemia-Reperfusion Injury
 xref: PMID:32452260



show annotations for term's descendants           Sort by:
Retina Reperfusion Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 treatment IDA RGD PMID:22143029 RGD:5686888 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772
JBrowse link
G Bad BCL2-associated agonist of cell death treatment IDA RGD PMID:23056591 RGD:10053711 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034
JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:23056591 RGD:10053711 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IDA RGD PMID:25535961 RGD:11522737 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Bcl2l1 Bcl2-like 1 treatment IEP RGD PMID:23056591 RGD:10053711 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907
JBrowse link
G Bdnf brain-derived neurotrophic factor ISO RGD PMID:10549664 RGD:8655861 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
JBrowse link
G Casp7 caspase 7 IEP RGD PMID:20702827 RGD:5684535 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:265,442,676...265,482,512
JBrowse link
G Cat catalase treatment IEP protein:decreased expression,decreased activity:retina: RGD PMID:22509733 RGD:9068919 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment IDA RGD PMID:24325836 RGD:11526144 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Clu clusterin IEP RGD PMID:15139011 RGD:1581194 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860
JBrowse link
G Cntf ciliary neurotrophic factor treatment IDA RGD PMID:8125754 RGD:8655591 NCBI chr 1:219,312,512...219,314,535
Ensembl chr 1:219,312,512...219,314,488
JBrowse link
G Dusp1 dual specificity phosphatase 1 treatment IMP RGD PMID:21094639 RGD:7495849 NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644
JBrowse link
G Fgf2 fibroblast growth factor 2 treatment IEP
ISO
RGD PMID:9561364 PMID:14975212 PMID:8125754 RGD:8554857, RGD:8655585, RGD:8655591 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493
JBrowse link
G Fxn frataxin ameliorates ISO RGD PMID:27537261 PMID:27537261 RGD:401793704, RGD:401793704 NCBI chr 1:231,300,457...231,323,989
Ensembl chr 1:231,300,150...231,323,989
JBrowse link
G Glul glutamate-ammonia ligase treatment IEP RGD PMID:22008240 RGD:401794422 NCBI chr13:68,519,500...68,585,554
Ensembl chr13:68,576,067...68,585,520
JBrowse link
G Hdac2 histone deacetylase 2 treatment ISO RGD PMID:23696608 RGD:9590210 NCBI chr20:42,101,815...42,126,486
Ensembl chr20:42,102,861...42,126,311
JBrowse link
G Hgf hepatocyte growth factor treatment ISO
IEP
mRNA,protein:increased expression:retina: RGD PMID:11818401 PMID:11818401 RGD:8548551, RGD:8548551 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851
JBrowse link
G Hmgb1 high mobility group box 1 IDA RGD PMID:21999229 RGD:10402064 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327
JBrowse link
G Hmox1 heme oxygenase 1 IEP associated with Glaucoma RGD PMID:20357190 RGD:4145289 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 IDA RGD PMID:21310899 RGD:10402767 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301
JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IMP
IEP
associated with Hypertension RGD PMID:10235552 PMID:15007035 RGD:8547704, RGD:8547707 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
JBrowse link
G Il1a interleukin 1 alpha IEP RGD PMID:7890488 RGD:7401191 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
JBrowse link
G Il1b interleukin 1 beta IEP RGD PMID:7890488 RGD:7401191 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 IEP mRNA:increased expression:retina: RGD PMID:16530172 RGD:7829807 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 IEP
ISO
mRNA:decreased expression:retina
protein:decreased expression:retina, blood vessel
RGD PMID:16330144 PMID:20132867 RGD:8662868, RGD:8662890 NCBI chr13:87,334,510...87,367,747
Ensembl chr13:87,334,216...87,368,678
JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 IEP protein:increased expression:retina RGD PMID:17026968 RGD:2317696 NCBI chr 5:78,024,139...78,147,071
Ensembl chr 5:78,024,139...78,142,188
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IEP RGD PMID:19668425 RGD:7495824 NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185
JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP
IDA
mRNA:altered expression:retina (rat)
protein:increased expression:retinal vasculature, retinal ganglion cell layer (rat)
RGD PMID:9950605 PMID:12634478 PMID:11496119 RGD:7771570, RGD:7775037, RGD:7775036 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase IEP protein:increased expression:retina, cytosol (rat) RGD PMID:19122832 RGD:13208943 NCBI chr11:84,612,943...84,690,025
Ensembl chr11:84,615,340...84,689,955
JBrowse link
G Ren renin treatment IMP RGD PMID:24709336 RGD:11039406 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543
JBrowse link
G Rnf2 ring finger protein 2 IEP RGD PMID:20740046 RGD:9491844 NCBI chr13:63,553,964...63,584,047
Ensembl chr13:66,083,653...66,133,161
JBrowse link
G Serpinf1 serpin family F member 1 ISO human protein in a mouse model RGD PMID:16822505 RGD:8554871 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,748,506...60,760,898
JBrowse link
G Sod2 superoxide dismutase 2 treatment IEP
ISO
protein:decreased activity:retina: RGD PMID:22240151 PMID:22240151 RGD:8158043, RGD:8158043 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Stat3 signal transducer and activator of transcription 3 treatment IDA RGD PMID:21858029 RGD:8694310 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:21031135 RGD:7794771 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
JBrowse link
G Tnf tumor necrosis factor IEP
IDA
IMP
protein:increased expression:retina: RGD PMID:18660426 PMID:18660426 PMID:18660426 RGD:7387281, RGD:7387281, RGD:7387281 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Vegfa vascular endothelial growth factor A IDA RGD PMID:17591953 RGD:7421609 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
G Xdh xanthine dehydrogenase treatment IMP RGD PMID:9288448 RGD:13210506 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    sensory system disease 7348
      eye disease 3565
        retinal disease 1474
          Retina Reperfusion Injury 38
Path 2
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      nervous system disease 14369
        Neurologic Manifestations 10446
          sensory system disease 7348
            eye disease 3565
              retinal disease 1474
                Retina Reperfusion Injury 38
paths to the root