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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hemorrhagic Shock
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Accession:DOID:9001708 term browser browse the term
Definition:Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.
Synonyms:primary_id: MESH:D012771


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Hemorrhagic Shock term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin treatment ISO
IEP 		RGD PMID:18403050 PMID:15973109 RGD:7364987, RGD:7364990 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371 		JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 severity IEP mRNA:decreased expression:liver RGD PMID:23810746 PMID:21643955 RGD:14367884, RGD:14367885 NCBI chr 1:227,627,977...227,667,877
Ensembl chr 1:227,627,448...227,672,523 		JBrowse link
G Angpt1 angiopoietin 1 ISO RGD PMID:18344375 RGD:2316067 NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696 		JBrowse link
G Arg2 arginase 2 IEP protein:increased expression:aorta (rat) RGD PMID:20699748 RGD:4143274 NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:103,668,988...103,694,375 		JBrowse link
G Bad BCL2-associated agonist of cell death IEP protein:decreased serine phosphorylation:lung RGD PMID:15345971 RGD:2292699 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bcl2 BCL2, apoptosis regulator IEP mRNA:increased expression:intestine RGD PMID:17693937 RGD:2293072 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 IEP protein:increased expression:liver, mitochondrion RGD PMID:17224795 RGD:1643525 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G C3 complement C3 IMP RGD PMID:26687560 RGD:408427361 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339 		JBrowse link
G Casp3 caspase 3 IEP associated with Brain Injuries, Traumatic RGD PMID:29061477 RGD:13782298 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 IEP associated with Brain Injuries, Traumatic RGD PMID:29061477 RGD:13782298 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Cfh complement factor H treatment ISO
IEP 		RGD PMID:18403050 PMID:15973109 PMID:18496585 RGD:7364987, RGD:7364990, RGD:11041173 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:54,062,531...54,164,532 		JBrowse link
G Cnr1 cannabinoid receptor 1 IMP mRNA, protein:increased expression:aorta, mesenteric artery RGD PMID:19493421 RGD:2314664 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252 		JBrowse link
G Cul5 cullin 5 IEP mRNA:altered expression:brain RGD PMID:12635525 RGD:2301433 NCBI chr 8:62,909,150...62,974,641
Ensembl chr 8:62,912,193...62,965,463 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 IEP
ISO 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:21192278 PMID:21168948 RGD:5128673 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21192278 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21192278 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:20539178 RGD:10401059 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725 		JBrowse link
G Esr1 estrogen receptor 1 severity IMP RGD PMID:20195535 RGD:4892252 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esr2 estrogen receptor 2 IDA RGD PMID:16859701 RGD:8694176 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G F2 coagulation factor II, thrombin IEP protein:decreased activity:blood (rat) RGD PMID:21550061 RGD:5132267 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246 		JBrowse link
G F8 coagulation factor VIII IEP protein:decreased expression:plasma RGD PMID:15748447 RGD:10450768 NCBI chr18:155,237...187,186
Ensembl chr18:155,309...186,683 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration ISO RGD PMID:23073658 RGD:9685733 NCBI chr10:14,223,023...14,225,736
Ensembl chr10:14,223,023...14,225,935 		JBrowse link
G Gja1 gap junction protein, alpha 1 IEP RGD PMID:19077877 RGD:7207423 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Gja5 gap junction protein, alpha 5 IEP RGD PMID:19077877 RGD:7207423 NCBI chr 2:187,291,227...187,310,770
Ensembl chr 2:187,234,674...187,318,512 		JBrowse link
G Glul glutamate-ammonia ligase treatment IEP RGD PMID:12766648 RGD:401794596 NCBI chr13:68,519,500...68,585,554
Ensembl chr13:68,576,067...68,585,520 		JBrowse link
G Gpt glutamic--pyruvic transaminase treatment IEP RGD PMID:16141011 RGD:401717565 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Hmox1 heme oxygenase 1 severity IMP
IEP 		RGD PMID:20514418 PMID:20819606 RGD:10755719, RGD:10755727 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hp haptoglobin IEP RGD PMID:20016403 RGD:5147418 NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A IEP mRNA:increased expression:liver RGD PMID:22266570 RGD:7257601 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO mRNA, protein:increased expression:lung (mouse)
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:21192278 PMID:19828841 RGD:4145497 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifng interferon gamma IEP protein:increased expression:plasma RGD PMID:19439114 RGD:2311495 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il10 interleukin 10 IEP protein:increased expression:serum, lymph RGD PMID:19160132 RGD:2311060 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:plasma RGD PMID:23589298 RGD:14695541 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1a interleukin 1 alpha IEP mRNA:increased expression:lung RGD PMID:15580020 RGD:2311100 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta severity IEP mRNA:increased expression:lung
protein:increased expression:kidney, serum (rat) 		RGD PMID:15580020 PMID:17545943 PMID:21336199 RGD:2311100, RGD:1626655, RGD:7175325 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 treatment IEP RGD PMID:24986445 RGD:10402801 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 IEP
ISO 		protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism
associated with Alcoholic Intoxication; protein:increased expression:serum 		CTD
RGD		 PMID:21192278 PMID:21168948 PMID:24163503 RGD:5128673, RGD:598148159 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEP protein: increased expression: lung and liver RGD PMID:22392145 RGD:7244173 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment IEP RGD PMID:16141011 RGD:401717565 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21192278 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment IDA RGD PMID:24204984 RGD:10041042 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor treatment IDA RGD PMID:22113495 RGD:7240568 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nfkbia NFKB inhibitor alpha treatment IEP RGD PMID:11557243 RGD:127285020 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos2 nitric oxide synthase 2 IEP mRNA, protein:increased expression:multiple RGD PMID:15854664 RGD:1580937 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP mRNA:increased expression: :multiple RGD PMID:15854664 PMID:29122552 RGD:1580937, RGD:13450929 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Otc ornithine transcarbamylase IEP protein:increased activity:serum (rat) RGD PMID:17224795 RGD:1643525 NCBI chr  X:15,126,358...15,202,473
Ensembl chr  X:15,126,358...15,239,555 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEP
ISO 		protein:increased phosphorylation, altered location:nucleus, endothelial cell, lung
protein:increased phosphorylation:nucleus, liver 		RGD PMID:17950078 PMID:17950083 PMID:18469645 RGD:2298842, RGD:2298841, RGD:2298781 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sirt1 sirtuin 1 treatment IMP
IEP 		protein:decreased expression:heart left ventricle RGD PMID:22113495 PMID:21554952 RGD:7240568, RGD:9585770 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 IMP
ISO 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17724433 PMID:19384202 RGD:6771334 NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:150,860,228...150,913,517 		JBrowse link
G Sod2 superoxide dismutase 2 treatment IEP RGD PMID:26073907 RGD:26923954 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Tfam transcription factor A, mitochondrial IEP RGD PMID:22469910 RGD:6767567 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 treatment IEP RGD PMID:16141011 RGD:401717565 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 treatment IEP RGD PMID:16141011 RGD:401717565 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tlr4 toll-like receptor 4 severity ISO RGD PMID:25049041 RGD:14697700 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor treatment IDA
ISO
IEP 		CTD Direct Evidence: marker/mechanism
associated with Alcoholic Intoxication; protein:increased expression:serum 		CTD
RGD		 PMID:21192278 PMID:24315526 PMID:24163503 RGD:10450602, RGD:598148159 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 ameliorates IDA RGD PMID:19333144 RGD:127284838 NCBI chr 9:20,259,227...20,276,879
Ensembl chr 9:20,261,408...20,276,892 		JBrowse link
G Vwf von Willebrand factor IEP protein:decreased expression:plasma RGD PMID:15748447 RGD:10450768 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    Pathological Conditions, Signs and Symptoms 13667
      Pathologic Processes 8430
        Hemorrhage 308
          Hemorrhagic Shock 57
            Hemorrhagic Shock and Encephalopathy Syndrome 0
paths to the root