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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Leukoaraiosis
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Accession:DOID:9001620 term browser browse the term
Definition:Non-specific white matter changes in the BRAIN, often seen after age 65. Changes include loss of AXONS; MYELIN pallor, GLIOSIS, loss of ependymal cells, and enlarged perivascular spaces. Leukoaraiosis is a risk factor for DEMENTIA and CEREBROVASCULAR DISORDERS.
Synonyms:exact_synonym: Leukoaraioses
 primary_id: MESH:D049292


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Leukoaraiosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cldn1 claudin 1 ISO DNA:SNPs: :rs17501010, rs893051,rs9290927(human) RGD PMID:25956626 RGD:11344876 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Klc1 kinesin light chain 1 ISO associated with hypertension;DNA:polymorphism:intron:5836G>C(human)
associated with hypertension;DNA:polymorphisms:5'utr:185A>C,406C>T (human)		 RGD PMID:17917076 PMID:17977659 RGD:5683912, RGD:5683914 NCBI chr 6:130,823,416...130,866,729
Ensembl chr 6:130,823,419...130,867,031 		JBrowse link
G Pmf1 polyamine-modulated factor 1 susceptibility ISO DNA:SNP: :rs2984613(human) RGD PMID:31396257 RGD:30296652 NCBI chr 2:173,848,074...173,868,272
Ensembl chr 2:173,848,074...173,868,270 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19050
    Pathological Conditions, Signs and Symptoms 13532
      Pathologic Processes 8240
        Leukoaraiosis 3
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