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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Nasal Polyps
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Accession:DOID:9001472 term browser browse the term
Definition:Focal accumulations of EDEMA fluid in the NASAL MUCOSA accompanied by HYPERPLASIA of the associated submucosal connective tissue. Polyps may be NEOPLASMS, foci of INFLAMMATION, degenerative lesions, or malformations.
Synonyms:exact_synonym: Nasal Polyp;   Nasal Polyposis
 xref: EFO:1000391;   MESH:D009298



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Nasal Polyps term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO associated with Chronic Rhinosinusitis;protein:increased expression:nasal sinus (human) RGD PMID:22223515 RGD:8657074 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Adrb2 adrenoceptor beta 2 susceptibility ISO DNA:polymorphism:p.R16G(human) RGD PMID:17621827 RGD:8548469 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type ISO mRNA:decreased expression:nasal cavity epithelium RGD PMID:20554417 RGD:5509597 NCBI chr10:55,456,923...55,469,239
Ensembl chr10:54,958,271...54,970,542
JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO mRNA:increased expression:nasal cavity epithelium
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:30643255 PMID:20554417 RGD:5509597 NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Ang angiogenin ISO RGD PMID:21711968 RGD:6892710 NCBI chr15:26,786,233...26,796,883 JBrowse link
G Anxa1 annexin A1 ISO RGD PMID:20549082 RGD:7421567 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Bdnf brain-derived neurotrophic factor ISO associated with Sinusitis;protein:decreased expression:respiratory system mucosa RGD PMID:19958603 RGD:4891064 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Cat catalase ISO protein:increased activity:nasal concha: RGD PMID:16287205 RGD:9479048 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 ISO associated with Sinusitis RGD PMID:20598643 RGD:4891418 NCBI chr10:67,625,962...67,628,740
Ensembl chr10:67,128,331...67,131,159
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 ISO mRNA:increased expression:nasal cavity epithelium RGD PMID:10415058 RGD:4145448 NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO protein:increased expression:sinus: RGD PMID:22287435 RGD:7483612 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 ISO associated with Allergic Rhinitis
associated with Rhinosinusitis
RGD PMID:19027509 PMID:22287435 RGD:7483586, RGD:7483612 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl24 C-C motif chemokine ligand 24 ISO mRNA:increased expression:nasal cavity epithelium RGD PMID:10415058 RGD:4145448 NCBI chr12:26,737,423...26,741,420
Ensembl chr12:21,100,835...21,104,893
JBrowse link
G Ccl26 C-C motif chemokine ligand 26 ISO associated with Sinusitis;mRNA:increased expression:nasal cavity epithelium RGD PMID:21303604 RGD:5130929 NCBI chr12:26,745,972...26,750,924
Ensembl chr12:21,109,421...21,114,335
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO RGD PMID:22287435 RGD:7483612 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 ISO associated with Rhinosinusitis RGD PMID:22287435 RGD:7483612 NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:52,474,168...52,498,603
JBrowse link
G Chia chitinase, acidic ISO associated with Sinusitis; mRNA:increased expression:mucosa of ethmoidal sinus (human) RGD PMID:16871939 RGD:5024927 NCBI chr 2:196,302,687...196,344,849
Ensembl chr 2:193,614,114...193,656,533
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 ISO associated with Sinusitis;mRNA:increased expression:respiratory system mucosa RGD PMID:19178793 RGD:5134986 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 ISO associated with Sinusitis;mRNA:increased expression:respiratory system mucosa RGD PMID:19178793 RGD:5134986 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 ISO protein:increased expression:nasal cavity epithelium
associated with Asthma
associated with Rhinitis;mRNA:increased expression:nasal cavity epithelium
RGD PMID:16739673 PMID:11591188 PMID:16689996 RGD:4889117, RGD:4848936, RGD:4783198 NCBI chr  X:75,734,281...75,762,873
Ensembl chr  X:71,663,821...71,690,121
JBrowse link
G Egr1 early growth response 1 ISO mRNA:increased expression:nasal polyp (human) RGD PMID:19158123 RGD:4890001 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fas Fas cell surface death receptor ISO protein:decreased expression:nasal polyp (human) RGD PMID:15283292 RGD:8662435 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fgf1 fibroblast growth factor 1 ISO RGD PMID:16720444 RGD:8655569 NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fgf2 fibroblast growth factor 2 ISO RGD PMID:16720444 RGD:8655569 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Gstm1 glutathione S-transferase mu 1 ISO associated with GSTT1 null genotype:DNA:deletion: : RGD PMID:16550944 RGD:4142528 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO DNA:deletion: : RGD PMID:19701760 RGD:4142518 NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Hgf hepatocyte growth factor ISO mRNA,protein:increased expression:nasal cavity mucosa: RGD PMID:16982975 RGD:8548613 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:nasal cavity epithelium RGD PMID:11593541 RGD:8547687 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma ISO protein:increased expression:nasal mucosa, tissue: RGD PMID:9149164 RGD:8158035 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 ISO mRNA:increased expression:nasal cavity mucosa: RGD PMID:18202785 RGD:8548875 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il10 interleukin 10 ISO RGD PMID:22462754 RGD:7364835 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 ISO associated with Rhinosinusitis;protein:increased expression:serum RGD PMID:23969075 RGD:8549540 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il16 interleukin 16 ISO associated with Sinusitis RGD PMID:17431659 RGD:5024933 NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:137,617,944...137,718,130
JBrowse link
G Il17a interleukin 17A ISO protein:increased expression:nose, serum
associated with rhinitis; protein:increased expression:nasal mucosa
RGD PMID:20506642 PMID:21091665 RGD:4889137, RGD:4889132 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1a interleukin 1 alpha susceptibility ISO associated with asthma;DNA:polymorphism:exon:
DNA:SNPs:exon:
RGD PMID:12752325 PMID:17638785 RGD:4142804, RGD:4142855 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il5ra interleukin 5 receptor subunit alpha ISO protein:increased expression:nasal mucus, serum RGD PMID:12752323 RGD:5128621 NCBI chr 4:141,186,749...141,221,348
Ensembl chr 4:139,632,066...139,668,544
JBrowse link
G Il9 interleukin 9 ISO associated with Bronchial Hyperreactivity RGD PMID:15007348 RGD:5128694 NCBI chr17:8,117,028...8,120,151
Ensembl chr17:8,111,772...8,114,895
JBrowse link
G Itgal integrin subunit alpha L ISO protein:increased expression:nasal cavity epithelium RGD PMID:11593541 RGD:8547687 NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:181,918,183...181,955,732
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO mRNA:decreased expression:nasal cavity epithelium RGD PMID:19158123 RGD:4890001 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kdr kinase insert domain receptor ISO protein:increased expression:inferior nasal concha: RGD PMID:12515274 RGD:8551781 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Kitlg KIT ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:15813808 NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:34,896,053...34,977,214
JBrowse link
G Lepr leptin receptor ISO mRNA:increased expression:nose RGD PMID:20422702 RGD:5129163 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Mbl2 mannose binding lectin 2 ISO associated with Sinusitis; protein:increased secretion:serum (human) RGD PMID:19593977 RGD:4889484 NCBI chr 1:237,429,873...237,465,567 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO mRNA,protein:increased expression:nasal cavity mucosa: RGD PMID:16982975 RGD:8548613 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO associated with Rhinosinusitis;mRNA:increased expression:nasal cavity mucosa RGD PMID:23064462 RGD:8549735 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment ISO associated with Rhinosinusitis;mRNA:increased expression:nasal cavity mucosa RGD PMID:23064462 PMID:21305560 RGD:8549735, RGD:8656001 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 susceptibility
disease_progression
ISO associated with Asthma, Aspirin-Induced; DNA:polymorphism:promoter: -1562C>T (human)
associated with Rhinosinusitis;mRNA:increased expression:nasal cavity mucosa
RGD PMID:19958602 PMID:23987197 PMID:23064462 RGD:5130861, RGD:8657056, RGD:8549735 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO RGD PMID:15715404 RGD:7364740 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:196,864,336...196,896,475
JBrowse link
G Nos2 nitric oxide synthase 2 ISO mRNA:increased expression:nasal mucosa
DNA:repeats:promoter
RGD PMID:20554417 PMID:18714530 RGD:5509597, RGD:4891508 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 ISO protein:increased expression:nasal mucosa (human) RGD PMID:15942806 RGD:7771559 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO associated with Sinusitis RGD PMID:21711960 RGD:6483796 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Pon1 paraoxonase 1 ISO protein:decreased activity:serum (human) RGD PMID:23238704 RGD:8547666 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B ISO associated with Chronic Rhinosinusitis;mRNA:increased expression:mucosa of paranasal sinus (human) RGD PMID:18391768 RGD:9999402 NCBI chr10:80,434,888...80,450,919
Ensembl chr10:79,938,066...79,954,083
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO associated with Cystic Fibrosis; protein:increased expression:nasal mucosa: RGD PMID:16517580 RGD:5143924 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO associated with Cystic Fibrosis; protein:increased expression:nasal mucosa: RGD PMID:16517580 RGD:5143924 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G RT1-Ba RT1 class II, locus Ba susceptibility ISO associated with intrinsic asthma;DNA:polymorphism:cds:HLA-DQA1*0201 (human)
DNA:polymorphism,haplotype: :HLA-DQA1*0201
RGD PMID:10718431 PMID:16890076 RGD:5147813, RGD:8547658 NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,575,134...4,579,744
JBrowse link
G RT1-Bb RT1 class II, locus Bb susceptibility ISO associated with intrinsic asthma;DNA:polymorphism, haplotype:cds:HLA-DQB1*0202 (human)
DNA:haplotype: : HLA-DQB1*0201;
RGD PMID:10718431 PMID:16890076 RGD:5147813, RGD:8547658 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G RT1-CE13 RT1 class I, locus CE13 susceptibility ISO DNA:polymorphisms:cds:HLA-B*07, HLA-B*57 (human, Turkish) RGD PMID:18922348 RGD:7364876 NCBI chr20:3,314,491...3,322,815 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 ISO associated with intrinsic asthma;DNA:polymorphisms:cds:HLA-DR7 (human) RGD PMID:10718431 RGD:5147813 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G Sod1 superoxide dismutase 1 ISO mRNA, protein:increased expression:middle nasal turbinate, lamella (human)
associated with Rhinosinusitis;protein:decreased expression:nasal mucosa:
RGD PMID:16540901 PMID:23921602 RGD:1581230, RGD:8547534 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 ISO associated with Rhinosinusitis;mRNA,protein:decreased expression:nasal mucosa: RGD PMID:23921602 RGD:8547534 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sod3 superoxide dismutase 3 ISO mRNA, protein:increased expression:middle nasal turbinate, lamella (human) RGD PMID:16540901 RGD:1581230 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO RGD PMID:22959364 RGD:8694314 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO associated with Rhinitis
mRNA:decreased expression:nasal cavity epithelium
RGD PMID:18423831 PMID:23406597 PMID:12761968 RGD:4145277, RGD:7394852, RGD:7394830 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tlr2 toll-like receptor 2 ISO associated with Cystic Fibrosis;mRNA:increased expression:inferior nasal concha: RGD PMID:15836755 RGD:8552992 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 ISO associated with Rhinosinusitis;mRNA,protein:increased expression: RGD PMID:23157229 RGD:7800741 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr7 toll-like receptor 7 ISO associated with Rhinosinusitis;mRNA,protein:increased expression: RGD PMID:23157229 RGD:7800741 NCBI chr  X:30,644,324...30,670,796
Ensembl chr  X:27,027,425...27,054,754
JBrowse link
G Tnc tenascin C ISO protein:increased expression:nasal cavity epithelium RGD PMID:12916355 RGD:4889591 NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:77,375,851...77,460,624
JBrowse link
G Tnf tumor necrosis factor ISO DNA:SNPs:promoter: RGD PMID:17638785 RGD:4142855 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO mRNA:decreased expression:nasal polyp (human) RGD PMID:19095579 RGD:5131442 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO mRNA:decreased expression:nasal polyp (human) RGD PMID:19095579 RGD:5131442 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:Turbinates: RGD PMID:12761968 RGD:7394830 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
Asthma and Nasal Polyps term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-Da RT1 class II, locus Da susceptibility ISO DNA:SNPs,haplotype:introns: RGD PMID:22391069 RGD:13506908 NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,512,911...4,518,455
JBrowse link
G Tbx21 T-box transcription factor 21 ISO ClinVar Annotator: match by term: Asthma and nasal polyps ClinVar PMID:15806396 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,082,322...82,098,831
JBrowse link
asthma, nasal polyps, and aspirin intolerance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15 arachidonate 15-lipoxygenase ISO ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance ClinVar PMID:17959182 PMID:21558275 PMID:25741868 PMID:30643255 NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Ltc4s leukotriene C4 synthase ISO ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance ClinVar PMID:25741868 NCBI chr10:35,060,002...35,066,466
Ensembl chr10:34,560,360...34,562,651
JBrowse link
G Ptger2 prostaglandin E receptor 2 susceptibility ISO CTD Direct Evidence: marker/mechanism OMIM
CTD
NCBI chr15:20,694,765...20,708,475
Ensembl chr15:18,217,285...18,228,714
JBrowse link
G Tbx21 T-box transcription factor 21 ISO ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance
CTD Direct Evidence: marker/mechanism
ClinVar
OMIM
CTD
PMID:25741868 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,082,322...82,098,831
JBrowse link
Bronchiectasis and Nasal Polyposis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wfdc2 WAP four-disulfide core domain 2 ISO ClinVar Annotator: match by term: BRONCHIECTASIS AND NASAL POLYPOSIS OMIM
ClinVar
PMID:38626355 NCBI chr 3:153,286,946...153,314,832
Ensembl chr 3:153,286,131...153,292,807
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19139
    Pathological Conditions, Signs and Symptoms 13625
      Anatomical Pathological Conditions 2868
        Polyps 492
          Nasal Polyps 77
            Asthma and Nasal Polyps 2
            Bronchiectasis and Nasal Polyposis 1
            Median Cleft Lip, Corpus Callosum, Lipoma, and Skin Polyps 0
            asthma, nasal polyps, and aspirin intolerance 4
Path 2
Term Annotations click to browse term
  disease 19139
    disease of anatomical entity 18451
      nervous system disease 14361
        Neurologic Manifestations 10463
          sensory system disease 7383
            Otorhinolaryngologic Diseases 1799
              nose disease 233
                Nasal Polyps 77
                  Asthma and Nasal Polyps 2
                  Bronchiectasis and Nasal Polyposis 1
                  Median Cleft Lip, Corpus Callosum, Lipoma, and Skin Polyps 0
                  asthma, nasal polyps, and aspirin intolerance 4
paths to the root