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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Leukocytosis
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Accession:DOID:9001039 term browser browse the term
Definition:A transient increase in the number of leukocytes in a body fluid.
Synonyms:exact_synonym: Leukocytoses;   Pleocytoses;   Pleocytosis
 primary_id: MESH:D007964


show annotations for term's descendants           Sort by:
Leukocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO CTD Direct Evidence: marker/mechanism CTD PMID:27725143 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022 		JBrowse link
G Csf3 colony stimulating factor 3 ISO associated with neoplasms; RGD PMID:18756972 RGD:11039421 NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860 		JBrowse link
G Csf3r colony stimulating factor 3 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19620628 NCBI chr 5:143,583,126...143,604,382
Ensembl chr 5:143,583,213...143,602,411 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27099147 PMID:27725143 NCBI chr12:12,660,035...12,735,584
Ensembl chr12:12,659,946...12,735,581 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:1884014 PMID:19633061 PMID:1581467 RGD:4142837, RGD:10450884 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO associated with Meningitis, Listeria; RGD PMID:10085034 RGD:11522759 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Itga4 integrin subunit alpha 4 IMP RGD PMID:12626659 RGD:9698418 NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039 		JBrowse link
G Kng2 kininogen 2 IDA RGD PMID:5116037 RGD:11059893 NCBI chr11:91,418,470...91,440,841
Ensembl chr11:91,414,207...91,441,259 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27725143 NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Npy5r neuropeptide Y receptor Y5 IDA RGD PMID:12417430 RGD:729324 NCBI chr16:27,822,055...27,830,012
Ensembl chr16:27,816,065...27,830,290 		JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27725143 NCBI chr 2:193,271,399...193,282,023
Ensembl chr 2:193,271,430...193,278,543 		JBrowse link
B-CELL EXPANSION WITH NFKB AND T-CELL ANERGY term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family, member 11 ISO ClinVar Annotator: match by term: B-cell expansion with NFKB and T-cell anergy OMIM
ClinVar		 PMID:9536098 PMID:17576681 PMID:18323416 PMID:23027925 PMID:23129749 More... NCBI chr12:18,735,088...18,872,045
Ensembl chr12:18,735,088...18,872,045 		JBrowse link
immunodeficiency 100 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oas1a 2'-5' oligoadenylate synthetase 1A ISO ClinVar Annotator: match by term: OAS1-related condition | ClinVar Annotator: match by term: Pulmonary alveolar proteinosis with hypogammaglobulinemia OMIM
ClinVar		 PMID:16014697 PMID:25741868 PMID:28492532 PMID:29185156 PMID:29455859 More... NCBI chr12:41,330,423...41,341,130
Ensembl chr12:41,285,211...41,341,128 		JBrowse link
Monoclonal B-Cell Lymphocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amz2 archaelysin family metallopeptidase 2 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr10:94,901,053...94,911,629
Ensembl chr10:94,901,129...94,911,627 		JBrowse link
G Apc APC regulator of WNT signaling pathway ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar PMID:25741868 PMID:28492532 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022 		JBrowse link
G Dazap1 DAZ associated protein 1 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr 7:10,074,342...10,098,810
Ensembl chr 7:10,074,849...10,095,599 		JBrowse link
G Fcnb ficolin B ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr 3:31,791,750...31,800,188
Ensembl chr 3:31,791,750...31,800,188 		JBrowse link
G Klhl6 kelch-like family member 6 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr11:94,475,262...94,514,653
Ensembl chr11:94,475,262...94,514,623 		JBrowse link
G Notch2 notch receptor 2 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar PMID:8755249 PMID:21378985 PMID:21378989 PMID:22891273 PMID:22891276 More... NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:188,299,336...188,432,823 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr 3:33,296,211...33,414,119
Ensembl chr 3:33,296,230...33,414,119 		JBrowse link
G Sec14l1 SEC14-like lipid binding 1 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr10:102,818,693...102,865,841
Ensembl chr10:102,818,693...102,865,839 		JBrowse link
G Slc35a5 solute carrier family 35, member A5 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr11:69,159,435...69,180,503
Ensembl chr11:69,159,384...69,180,502 		JBrowse link
G Sp4 Sp4 transcription factor ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr 6:145,330,416...145,395,750
Ensembl chr 6:145,330,416...145,395,146 		JBrowse link
G Tmed9 transmembrane p24 trafficking protein 9 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr17:9,034,797...9,039,311
Ensembl chr17:9,034,823...9,039,319 		JBrowse link
G Vmp1 vacuole membrane protein 1 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr10:71,903,223...72,002,337
Ensembl chr10:71,903,227...72,002,319 		JBrowse link
Monocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tet2 tet methylcytosine dioxygenase 2 ISO RGD PMID:24218139 RGD:11038772 NCBI chr 2:224,662,654...224,746,819
Ensembl chr 2:224,662,654...224,746,186 		JBrowse link
Neutrophilia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:2475183 RGD:11039032 NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860 		JBrowse link
G Ptafr platelet-activating factor receptor treatment IMP associated with Scorpion Stings RGD PMID:10770284 RGD:10043145 NCBI chr 5:150,049,322...150,079,060
Ensembl chr 5:150,049,460...150,079,408 		JBrowse link
Persistent Polyclonal B-Cell Lymphocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family, member 11 ISO DNA:missense mutations:cds:p.E127G, p.G116S (human) RGD PMID:23129749 RGD:11100033 NCBI chr12:18,735,088...18,872,045
Ensembl chr12:18,735,088...18,872,045 		JBrowse link
transient myeloproliferative syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata1 GATA binding protein 1 ISO ClinVar Annotator: match by term: TRANSIENT ABNORMAL MYELOPOIESIS | ClinVar Annotator: match by term: Transient myeloproliferative syndrome
CTD Direct Evidence: marker/mechanism 		ClinVar
CTD
OMIM
RGD		 PMID:24056718 PMID:25741868 PMID:27993330 PMID:28492532 PMID:14636651 RGD:10450612 NCBI chr  X:17,193,291...17,209,462
Ensembl chr  X:17,201,633...17,209,459 		JBrowse link
G Runx1 RUNX family transcription factor 1 ISO ClinVar Annotator: match by term: Transient myeloproliferative disorder of Down syndrome ClinVar PMID:10068652 PMID:12200707 PMID:15156185 PMID:23817177 PMID:28492532 NCBI chr11:45,325,778...45,560,300
Ensembl chr11:45,329,044...45,564,925 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19150
    Pathological Conditions, Signs and Symptoms 13669
      Pathologic Processes 8404
        Leukocytosis 28
          Holoprosencephaly, Recurrent Infections, and Monocytosis 0
          Leukemoid Reaction + 2
          Lymphocytosis + 13
          Monocytosis 1
          Neutrophilia 2
          immunodeficiency 100 1
Path 2
Term Annotations click to browse term
  disease 19150
    disease of anatomical entity 18458
      Hemic and Lymphatic Diseases 4334
        hematopoietic system disease 3840
          leukocyte disease 1342
            Leukocytosis 28
              Holoprosencephaly, Recurrent Infections, and Monocytosis 0
              Leukemoid Reaction + 2
              Lymphocytosis + 13
              Monocytosis 1
              Neutrophilia 2
              immunodeficiency 100 1
paths to the root