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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Heavy Metal Toxicity
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Accession:DOID:9000659 term browser browse the term
Definition:Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of HEAVY METALS. Acute and chronic exposures can cause ANEMIA; KIDNEY and LIVER damage; PULMONARY EDEMA; MEMORY LOSS and behavioral changes; bone deformities in children; and MISCARRIAGE or PREMATURE LABOR in pregnant women. (MESH)
Synonyms:exact_synonym: chronic heavy metal poisoning;   heavy metal poisoning
 primary_id: MESH:D000075322
 xref: EFO:1001518


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Heavy Metal Toxicity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Daxx death-domain associated protein IEP mRNA:increased expression:liver: RGD PMID:17692352 RGD:9587799 NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Kdm3b lysine demethylase 3B ISO CTD Direct Evidence: therapeutic CTD PMID:21262293 NCBI chr18:26,655,004...26,710,814
Ensembl chr18:26,380,964...26,436,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19139
    Chemically-Induced Disorders 1462
      Poisoning 790
        Heavy Metal Toxicity 2
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