RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Penetrating Wounds
Accession: DOID:9000656
browse the term
Definition: Wounds caused by objects penetrating the skin.
Synonyms: exact_synonym: Penetrating Wound
primary_id: MESH:D014950
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C3
complement C3
treatment
ISO
RGD
PMID:22007700
RGD:11040781
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Cd36
CD36 molecule
ISO
associated with Diabetes Mellitus, Type 2;mRNA:decreased expression:macrophage
RGD
PMID:21803601
RGD:6893492
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cd40lg
CD40 ligand
treatment
IDA
RGD
PMID:25153915
RGD:11352274
NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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Cxcl12
C-X-C motif chemokine ligand 12
ISO
associated with Diabetes Mellitus
RGD
PMID:17950070
RGD:2306556
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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Epo
erythropoietin
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:21326299
RGD:10401063
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Fgf10
fibroblast growth factor 10
treatment
ISO
human protein in rat model
RGD
PMID:10417753
RGD:126928129
NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866
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Hgf
hepatocyte growth factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12890377
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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Icam1
intercellular adhesion molecule 1
IEP
mRNA:increased expression:granulation tissue (rat)
RGD
PMID:20638379
RGD:4145377
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Il10
interleukin 10
IDA
associated with Diabetes Mellitus, Experimental
RGD
PMID:26101070
RGD:11049529
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Mmp3
matrix metallopeptidase 3
IEP
associated with Diabetes Mellitus, Type 2
RGD
PMID:21649785
RGD:8694117
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
RGD
PMID:22092840 PMID:22615899
RGD:6771175 , RGD:6771227
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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Pgf
placental growth factor
ISO
RGD
PMID:17194893
RGD:6483614
NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
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Serpine1
serpin family E member 1
IEP
mRNA:increased expression:dorsal skin (rat)
RGD
PMID:25794881
RGD:11075080
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Slpi
secretory leukocyte peptidase inhibitor
IEP
RGD
PMID:22020578
RGD:9999424
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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Tnf
tumor necrosis factor
IEP
associated with Diabetes Mellitus, Experimental
RGD
PMID:26101070
RGD:11049529
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Xdh
xanthine dehydrogenase
treatment
IEP
RGD
PMID:8121173
RGD:13209015
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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Fgf2
fibroblast growth factor 2
ISO
mRNA:increased expression:retina
RGD
PMID:9268592
RGD:8655567
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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Neo1
neogenin 1
IEP
protein:increased expression:retina
RGD
PMID:21887516
RGD:9850142
NCBI chr 8:59,273,860...59,426,486
Ensembl chr 8:59,275,569...59,430,348
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Rgma
repulsive guidance molecule BMP co-receptor a
IEP
protein:increased expression:retina
RGD
PMID:21887516
RGD:9850142
NCBI chr 1:127,128,934...127,172,918
Ensembl chr 1:127,128,934...127,172,918
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Entpd1
ectonucleoside triphosphate diphosphohydrolase 1
IEP
protein:increased expression,increased activity:cerebral cortex:
RGD
PMID:16672190
RGD:9685448
NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317
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Fgfr1
Fibroblast growth factor receptor 1
IEP
mRNA,protein:increased expression:astrocyte,macrophage,neutrophil:
RGD
PMID:11168551
RGD:10402049
NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
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Gfap
glial fibrillary acidic protein
ISO
RGD
PMID:10225952
RGD:6480471
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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Pdgfb
platelet derived growth factor subunit B
IEP
protein:increased expression:neuron:
RGD
PMID:7526956
RGD:10449485
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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Vim
vimentin
ISO
RGD
PMID:10225952
RGD:6480471
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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