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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Subarachnoid Hemorrhage
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Accession:DOID:9000438 term browser browse the term
Definition:Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
Synonyms:exact_synonym: Aneurysmal Subarachnoid Hemorrhage;   Aneurysmal Subarachnoid Hemorrhages;   Intracranial Subarachnoid Hemorrhage;   Intracranial Subarachnoid Hemorrhages;   Perinatal Subarachnoid Hemorrhage;   Perinatal Subarachnoid Hemorrhages;   SAH (Subarachnoid Hemorrhage);   SAHs (Subarachnoid Hemorrhage);   Spontaneous Subarachnoid Hemorrhage;   Spontaneous Subarachnoid Hemorrhages;   Subarachnoid Hemorrhages
 primary_id: MESH:D013345
 xref: EFO:0000713;   NCI:C50757


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Subarachnoid Hemorrhage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 treatment IMP RGD PMID:24114458 RGD:10003028 NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:increased expression:cerebrospinal fluid RGD PMID:22230897 RGD:8695949 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adora1 adenosine A1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18950269 NCBI chr13:48,210,922...48,247,826
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Ager advanced glycosylation end product-specific receptor IEP mRNA, protein:increased expression:brain RGD PMID:24291745 RGD:8696000 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Aif1 allograft inflammatory factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27157545 NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Apoe apolipoprotein E ISO GAD PMID:15118671 RGD:1331525 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Aqp4 aquaporin 4 exacerbates IEP
IMP		 mRNA:increased expression:brain: RGD PMID:33574749 PMID:33574749 RGD:127284879, RGD:127284879 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Aqp4em1Hrt aquaporin 4; TALEN induced mutant 1, Hrt exacerbates IMP RGD PMID:33574749 RGD:127284879
G Bcl2 BCL2, apoptosis regulator treatment IEP RGD PMID:26163325 RGD:13782347 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 IEP protein:increased expression:brain RGD PMID:22521819 RGD:6483046 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bnip3 BCL2 interacting protein 3 treatment IEP RGD PMID:23850688 RGD:11561986 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G C3 complement C3 treatment IEP RGD PMID:26518242 RGD:11040780 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Casp3 caspase 3 treatment ISO
IDA		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:24602480 PMID:26163325 RGD:13782347 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 treatment IDA RGD PMID:26163325 RGD:13782347 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccl20 C-C motif chemokine ligand 20 IEP mRNA:increased expression:cerebral artery RGD PMID:17977275 RGD:7488893 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 IEP mRNA:increased expression:lung RGD PMID:20731855 RGD:4145368 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cybb cytochrome b-245 beta chain IEP Protein:increased expression:cerebral cortex
mRNA:increased expression:cerebral vessel:		 RGD PMID:16671452 PMID:12142572 RGD:1599680, RGD:11040582 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 ISO DNA:snp:cds:p.I118V (human) RGD PMID:18566305 RGD:5685415 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 treatment IEP RGD PMID:30226536 RGD:35316073 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8587695 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednrb endothelin receptor type B ISO CTD Direct Evidence: marker/mechanism CTD PMID:8587695 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:23907045 RGD:10400909 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 treatment ISO RGD PMID:28756200 RGD:151893490 NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 treatment IMP
IEP		 RGD PMID:29169414 PMID:30226536 RGD:34901873, RGD:35316073 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Esr1 estrogen receptor 1 IEP protein:increased expression:dentate gyrus RGD PMID:23465388 RGD:8553242 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gli1 GLI family zinc finger 1 IEP mRNA, protein:increased expression:brain RGD PMID:23933201 RGD:12859044 NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO protein:increased expression:plasma RGD PMID:32326289 RGD:401827845 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment IDA RGD PMID:27026509 RGD:13792767 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsn gelsolin disease_progression
severity		 IEP
ISO		 mRNA, protein:altered expression:cerebral cortex (rat)
protein:decreased expression:blood plasma (human)		 RGD PMID:25744577 PMID:23880145 RGD:11055426, RGD:329333027 NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 IEP mRNA,protein:decreased expression:hippocampus: RGD PMID:22378889 RGD:9686397 NCBI chr 2:51,228,710...51,632,806
Ensembl chr 2:49,495,771...49,899,774 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP protein:increased expression:brain RGD PMID:15703702 RGD:1626323 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 IMP
IEP
ISO		 mRNA:increased expression:subarachnoid space RGD PMID:16543643 PMID:19686725 PMID:14657544 RGD:1582702, RGD:4145300, RGD:1598406 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 IEP mRNA:increased expression:brain stem RGD PMID:14753490 RGD:1624246 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B IEP RGD PMID:17542534 RGD:1626451 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP mRNA:increased expression:lung (rat) RGD PMID:20731855 RGD:4145368 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:27157545 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO rat model treated with human protein RGD PMID:22679224 RGD:7051590 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27157545 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irf9 interferon regulatory factor 9 ameliorates IMP RGD PMID:29480757 RGD:125093745 NCBI chr15:33,065,422...33,071,881
Ensembl chr15:29,095,789...29,101,236 		JBrowse link
G Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 treatment IEP RGD PMID:22420318 RGD:8662908 NCBI chr13:87,334,510...87,367,747
Ensembl chr13:84,802,009...84,835,461 		JBrowse link
G Lcn2 lipocalin 2 ameliorates ISO RGD PMID:26463936 RGD:126781835 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 treatment IEP RGD PMID:30226536 RGD:35316073 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 treatment IEP RGD PMID:29273596 RGD:155804269 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mmp1 matrix metallopeptidase 1 no_association ISO RGD PMID:11546917 RGD:1582365 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp13 matrix metallopeptidase 13 IDA RGD PMID:16961140 RGD:1582545 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp2 matrix metallopeptidase 2 IDA RGD PMID:22475348 RGD:8657107 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:27157545 PMID:17410600 RGD:1642039 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 treatment IEP RGD PMID:22304528 RGD:10412722 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ngb neuroglobin IEP protein:increased expression:cerebral cortex RGD PMID:24281943 RGD:9743950 NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830 		JBrowse link
G Nlk nemo like kinase disease_progression IEP RGD PMID:23325309 RGD:12791279 NCBI chr10:63,467,388...63,590,960
Ensembl chr10:63,438,222...63,589,730 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO mRNA:increased expression:brainstem, basilar artery (mouse)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17053178 PMID:21915076 RGD:5509046 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 IEP mRNA:increased expression:parietal cortex, arteriole (rat) RGD PMID:11273938 RGD:7794687 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 IEP mRNA, protein:increased expression:brain RGD PMID:21259333 RGD:5133235 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nrg1 neuregulin 1 treatment ISO RGD PMID:28756200 RGD:151893490 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Ntn1 netrin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29162556 NCBI chr10:52,899,933...53,098,591
Ensembl chr10:52,899,934...53,085,326 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IDA RGD PMID:21193742 RGD:5684779 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Pdcd10 programmed cell death 10 IEP protein:decreased expression:brain, microglial cell (rat) RGD PMID:32302649 RGD:401827168 NCBI chr 2:162,602,516...162,644,690
Ensembl chr 2:160,303,449...160,346,018 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta ameliorates IMP RGD PMID:29480757 RGD:125093745 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta treatment ISO RGD PMID:28756200 RGD:151893490 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pkd1l1 polycystin 1 like 1, transient receptor potential channel interacting susceptibility ISO DNA:polymorphism:cds:p.Gly243Asp(human) RGD PMID:16741147 RGD:155630602 NCBI chr14:83,552,964...83,670,062
Ensembl chr14:83,545,469...83,638,498 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:29162556 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase treatment IEP RGD PMID:28546552 RGD:13432565 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Ptch1 patched 1 IEP mRNA, protein:increased expression:brain RGD PMID:23933201 RGD:12859044 NCBI chr17:1,548,449...1,613,461
Ensembl chr17:1,542,877...1,607,333 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:21725746 RGD:5508204 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:27157545 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Shh sonic hedgehog signaling molecule IEP mRNA, protein:increased expression:brain RGD PMID:23933201 RGD:12859044 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Smo smoothened, frizzled class receptor treatment IDA RGD PMID:28149272 RGD:150521623 NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 IEP mRNA, protein:increased expression, increased phosphorylation:cerebral artery RGD PMID:24517975 RGD:8694356 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:17542534 RGD:1626451 NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Tjp1 tight junction protein 1 IDA protein:altered localization RGD PMID:18854840 RGD:2325137 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tlr4 toll-like receptor 4 IEP mRNA, protein:increased expression:brain RGD PMID:19719951 RGD:4144093 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 treatment IDA
IEP		 mRNA,protein:decreased expression:brain RGD PMID:30226536 PMID:30226536 RGD:35316073, RGD:35316073 NCBI chr 7:132,405,217...132,422,492
Ensembl chr 7:130,527,316...130,543,633 		JBrowse link
G Tnc tenascin C IEP protein:increased expression:basilar artery RGD PMID:19589197 RGD:4889600 NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
G Tnf tumor necrosis factor IEP
ISO		 protein:increased expression:brain
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:27157545 PMID:19719951 RGD:4144093 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 treatment
severity		 IEP
ISO		 RGD PMID:30910643 PMID:33727099 RGD:127284863, RGD:127284864 NCBI chr 9:20,259,227...20,276,879
Ensembl chr 9:12,763,819...12,779,203 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IEP protein:increased expression:entorhinal cortex RGD PMID:24114458 RGD:10003028 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532 		JBrowse link
G Unc5b unc-5 netrin receptor B ISO CTD Direct Evidence: marker/mechanism CTD PMID:29162556 NCBI chr20:28,697,726...28,764,474
Ensembl chr20:28,697,726...28,764,537 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator treatment ISO RGD PMID:28756200 RGD:151893490 NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
Traumatic Subarachnoid Hemorrhage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 treatment IMP RGD PMID:18854840 RGD:2325137 NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19134
    Pathological Conditions, Signs and Symptoms 13617
      Pathologic Processes 8330
        Hemorrhage 310
          Intracranial Hemorrhages 165
            Subarachnoid Hemorrhage 79
              Traumatic Subarachnoid Hemorrhage 1
              intracranial berry aneurysm 1 0
              intracranial berry aneurysm 4 0
              intracranial berry aneurysm 6 0
              intracranial berry aneurysm 7 0
              intracranial berry aneurysm 8 0
              intracranial berry aneurysm 9 0
Path 2
Term Annotations click to browse term
  disease 19134
    disease of anatomical entity 18447
      nervous system disease 14354
        central nervous system disease 12627
          brain disease 11847
            cerebrovascular disease 1005
              Intracranial Hemorrhages 165
                Subarachnoid Hemorrhage 79
                  Traumatic Subarachnoid Hemorrhage 1
                  intracranial berry aneurysm 1 0
                  intracranial berry aneurysm 4 0
                  intracranial berry aneurysm 6 0
                  intracranial berry aneurysm 7 0
                  intracranial berry aneurysm 8 0
                  intracranial berry aneurysm 9 0
paths to the root