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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chronic Intermittent Hypoxia
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Accession:DOID:9000288 term browser browse the term
Definition:This condition involves repetitive cycles of hypoxia and normoxia, which resembles the fluctuation of oxygen saturation in obstructive sleep apnea.
Synonyms:exact_synonym: CIH


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Chronic Intermittent Hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IEP mRNA:increased expression:carotid body RGD PMID:24036592 RGD:11039031 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Agt angiotensinogen IEP mRNA, protein:increased expression:type I cell of carotid body RGD PMID:24036592 RGD:11039031 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a IEP mRNA:increased expression:kidney cortex (rat) RGD PMID:32416216 RGD:401793731 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660 		JBrowse link
G Ahr aryl hydrocarbon receptor IEP mRNA:increased expression:kidney cortex, kidney medulla, liver (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator IEP mRNA:increased expression:liver, visceral adipose tissue (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:26769958 RGD:13792505 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IDA RGD PMID:26769958 RGD:13792505 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Becn1 beclin 1 IEP RGD PMID:24990154 RGD:11561988 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002 		JBrowse link
G Bnip3 BCL2 interacting protein 3 IEP RGD PMID:24990154 RGD:11561988 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP mRNA, protein:increased expression:liver (rat) RGD PMID:32626927 RGD:401959337 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP mRNA:increased expression:kidney cortex, kidney medulla, liver (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Epas1 endothelial PAS domain protein 1 IEP mRNA:increased expression:kidney medulla (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729 		JBrowse link
G Fadd Fas associated via death domain treatment IEP RGD PMID:26769958 RGD:13792505 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976 		JBrowse link
G Fn1 fibronectin 1 IEP mRNA:increased expression:kidney cortex (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP mRNA:increased expression:kidney cortex, kidney medulla (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha IEP mRNA:increased expression:kidney cortex, kidney medulla (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 1:86,846,196...86,878,527
Ensembl chr 1:86,850,554...86,877,838 		JBrowse link
G Hk1 hexokinase 1 IEP mRNA, protein:increased expression:cardiac ventricle RGD PMID:24525799 RGD:11353961 NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,773,220...30,874,814 		JBrowse link
G Hk2 hexokinase 2 IEP mRNA, protein:increased expression:cardiac ventricle RGD PMID:24525799 RGD:11353961 NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 IEP mRNA:increased expression:kidney cortex, kidney medulla, liver (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP mRNA, protein:increased expression:liver (rat) RGD PMID:32626927 RGD:401959337 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Il1b interleukin 1 beta IEP mRNA, protein:increased expression:liver (rat) RGD PMID:32626927 RGD:401959337 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Lpl lipoprotein lipase treatment IEP RGD PMID:29968701 RGD:13793400 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha IEP RGD PMID:24990154 RGD:11561988 NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:164,243,093...164,244,850 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 IEP mRNA:increased expression:kidney, liver (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEP mRNA:increased expression:kidney cortex (rat)
protein:increased expression:liver (rat) 		RGD PMID:32416216 PMID:32626927 RGD:401793731, RGD:401959337 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Ren renin IEP mRNA:increased expression:kidney medulla (rat) RGD PMID:32416216 RGD:401793731 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Tlr4 toll-like receptor 4 treatment IMP RGD PMID:32626927 RGD:401959337 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor IEP mRNA, protein:increased expression:liver (rat) RGD PMID:32626927 RGD:401959337 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 IEP mRNA, protein:increased expression:liver (rat) RGD PMID:32626927 RGD:401959337 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vegfa vascular endothelial growth factor A IEP mRNA:increased expression:kidney medulla (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Vim vimentin IEP mRNA:increased expression:kidney cortex, kidney medulla (rat) RGD PMID:32416216 RGD:401793731 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      nervous system disease 14369
        central nervous system disease 12646
          brain disease 11866
            Brain Hypoxia 138
              Chronic Intermittent Hypoxia 31
paths to the root