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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Systemic Inflammatory Response Syndrome
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Accession:DOID:9000169 term browser browse the term
Definition:A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA <36 degrees C; (2) TACHYCARDIA >90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.
Synonyms:exact_synonym: Sepsis Syndrome;   Sepsis Syndromes
 primary_id: MESH:D018746
 xref: EFO:1001478


show annotations for term's descendants           Sort by:
Systemic Inflammatory Response Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2 microglobulin ISO associated with infant, premature;protein:increased expression:urine RGD PMID:19527385 RGD:6482709 NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:129,549,318...129,555,356 		JBrowse link
G Cfh complement factor H ISO RGD PMID:20351616 RGD:5684556 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:54,062,531...54,164,532 		JBrowse link
G F3 coagulation factor III, tissue factor ISO RGD PMID:9366751 RGD:11341681 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369 		JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:22253906 RGD:7175262 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Mir223 microRNA 223 ISO RNA:increased expression:plasma: RGD PMID:24680405 RGD:21408586 NCBI chr  X:65,151,383...65,151,492
Ensembl chr  X:65,151,383...65,151,492 		JBrowse link
G Nos2 nitric oxide synthase 2 IEP protein:increased expression:ileum, liver (rat) RGD PMID:21975127 RGD:5508740 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Plaur plasminogen activator, urokinase receptor disease_progression ISO RGD PMID:18197443 RGD:6484114 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130 		JBrowse link
G Thbd thrombomodulin ISO protein:increased expression:blood RGD PMID:15187749 RGD:5685024 NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:156,306,632...156,320,582 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B IEP mRNA, protein:increased expression:carotid body, jugular ganglion, nodose ganglion (rat) RGD PMID:21195213 RGD:5130879 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:162,353,848...162,387,411 		JBrowse link
G Vdr vitamin D receptor susceptibility ISO associated with pneumonia; DNA:SNP: :rs2239185(human) RGD PMID:25367052 RGD:11074745 NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:130,866,745...130,916,757 		JBrowse link
Bacteremia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 IEP associated with Experimental Liver Cirrhosis; protein:decreased expression:serum RGD PMID:11349015 RGD:408395143 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO associated with Febrile Neutropenia;protein:increased expression:serum (human) RGD PMID:22584776 RGD:11528568 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta ISO associated with alcohol use disorder;mRNA:increased expression:bone marrow (mouse) RGD PMID:28784931 RGD:40903040 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Cfh complement factor H ISO associated with Meningococcal Infections; RGD PMID:22104107 RGD:7364945 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:54,062,531...54,164,532 		JBrowse link
G Cish cytokine inducible SH2-containing protein susceptibility ISO ClinVar Annotator: match by term: Bacteremia, susceptibility to, 2
CTD Direct Evidence: marker/mechanism 		ClinVar
CTD
OMIM		 PMID:20484391 NCBI chr 8:116,850,969...116,855,917
Ensembl chr 8:116,850,773...116,855,986 		JBrowse link
G Cpb2 carboxypeptidase B2 IEP protein:decreased activity:plasma RGD PMID:17911187 RGD:2313646 NCBI chr15:56,967,128...57,015,964
Ensembl chr15:56,966,839...57,015,962 		JBrowse link
G Crp C-reactive protein ISO protein:increased expression:serum: RGD PMID:18443549 RGD:9491402 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514 		JBrowse link
G Csf2 colony stimulating factor 2 treatment ISO RGD PMID:2192004 RGD:10449532 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031 		JBrowse link
G Fcgr2a Fc gamma receptor 2A ISO associated with Pneumonia;DNA:SNP: :p.H131R (rs1801274) (human) RGD PMID:21317643 RGD:5147986 NCBI chr13:85,813,516...85,830,269
Ensembl chr13:85,855,437...85,864,394
Ensembl chr13:85,855,437...85,864,394 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase severity ISO RGD PMID:11565076 RGD:5508478 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO mRNA:increased expression:lung,thymus,spleen: RGD PMID:24891762 RGD:11354979 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Il17a interleukin 17A ISO associated with Respiratory Distress Syndrome, Adult; protein:increased expression:serum RGD PMID:21062445 RGD:5128683 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il27 interleukin 27 ISO protein:increased expression:blood serum (human) RGD PMID:26514771 RGD:126790515 NCBI chr 1:190,603,684...190,609,292
Ensembl chr 1:190,603,522...190,609,258 		JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 ISO protein:increased expression:liver, serum RGD PMID:33348064 RGD:40907057 NCBI chr16:6,086,985...6,102,162
Ensembl chr16:6,086,973...6,102,160 		JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 ISO ClinVar Annotator: match by term: Bacteremia, susceptibility to, 2 ClinVar PMID:20484391 NCBI chr 8:116,808,429...116,842,228
Ensembl chr 8:116,808,429...116,842,228 		JBrowse link
G Mbl2 mannose binding lectin 2 treatment ISO associated with Multiple Myeloma:DNA:polymorphism:exon: RGD PMID:16953214 RGD:11530047 NCBI chr 1:237,429,873...237,465,567
Ensembl chr 1:237,429,973...237,437,546 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 severity ISO associated with Staphylococcal Infections; RGD PMID:24086711 RGD:13204726 NCBI chr19:34,555,832...34,596,281
Ensembl chr19:34,555,832...34,722,846 		JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: therapeutic CTD PMID:1430592 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696 		JBrowse link
G Plaur plasminogen activator, urokinase receptor severity ISO RGD PMID:21332843 RGD:6483799 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130 		JBrowse link
G Serpinc1 serpin family C member 1 treatment ISO RGD PMID:2679067 RGD:11035251 NCBI chr13:75,790,558...75,804,826
Ensembl chr13:75,790,546...75,817,643 		JBrowse link
G Sod2 superoxide dismutase 2 ISO mRNA:increased expression:liver: RGD PMID:24253037 RGD:26923958 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Tirap TIR domain containing adaptor protein ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Bacteremia, susceptibility to, 1 		CTD
ClinVar
OMIM		 PMID:16991088 PMID:17322885 PMID:18305471 PMID:25741868 NCBI chr 8:41,789,557...41,805,903
Ensembl chr 8:41,791,878...41,796,312 		JBrowse link
G Tlr4 toll-like receptor 4 susceptibility ISO DNA:polymorphisms:cds:p.D299G, T399I (human) RGD PMID:18180796 RGD:4144194 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
bacterial sepsis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem1 triggering receptor expressed on myeloid cells 1 treatment
ameliorates
exacerbates 		ISO
IDA 		associated with bacterial pneumonia RGD PMID:21507332 PMID:16960786 PMID:17230441 RGD:126925982, RGD:127229902, RGD:126928125 NCBI chr 9:20,259,227...20,276,879
Ensembl chr 9:20,261,408...20,276,892 		JBrowse link
Candidemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 molecule ameliorates ISO associated with endotoxemia RGD PMID:32154791 RGD:127345119 NCBI chr 2:174,721,522...174,725,029
Ensembl chr 2:174,721,522...174,725,029 		JBrowse link
G Ephb2 Eph receptor B2 exacerbates ISO RGD PMID:33685996 RGD:127229905 NCBI chr 5:154,179,065...154,360,459
Ensembl chr 5:154,179,065...154,360,615 		JBrowse link
cerebral malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 susceptibility ISO DNA:SNP:intron 1: C>T RGD PMID:20117248 RGD:40818420 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596 		JBrowse link
G Aqp4 aquaporin 4 disease_progression ISO protein:increased expression:astrocyte: RGD PMID:21904632 RGD:8698661 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098 		JBrowse link
G Cast calpastatin ISO protein:increased express:brain RGD PMID:16236382 RGD:5509817 NCBI chr 2:5,707,633...5,817,213
Ensembl chr 2:5,707,640...5,817,180 		JBrowse link
G Cd36 CD36 molecule ISO RGD PMID:17367535 RGD:6893527 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Clec12a C-type lectin domain family 12, member A ameliorates ISO RGD PMID:31269448 RGD:41412201 NCBI chr 4:164,484,162...164,502,793
Ensembl chr 4:164,484,162...164,510,233 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 treatment ISO RGD PMID:25682948 RGD:40400741 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891 		JBrowse link
G Il33 interleukin 33 treatment ISO protein:increased expression:brain RGD PMID:25659095 PMID:25682948 RGD:39938955, RGD:40400741 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901 		JBrowse link
G Jak3 Janus kinase 3 ISO RGD PMID:22363534 RGD:11531103 NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,420,415...18,433,222 		JBrowse link
G Lta lymphotoxin alpha ISO RGD PMID:12021316 RGD:10449455 NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,623,527...3,625,533 		JBrowse link
G Nrg1 neuregulin 1 treatment ISO mRNA, protein:increased expression:cerebral cortex (mouse)
human protein in a mouse model 		RGD PMID:29636063 PMID:24433482 RGD:39456084, RGD:39456102 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO RGD PMID:25775137 RGD:38599200 NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:54,478,603...54,529,509 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 ISO mRNA:decreased expression:brain (mouse) RGD PMID:29107705 RGD:39456137 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO RGD PMID:12228317 RGD:5131158 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:162,353,848...162,387,411 		JBrowse link
Endotoxemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 IEP RGD PMID:9828229 RGD:1598596 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A IEP mRNA:decreased expression:liver (rat) RGD PMID:26977098 RGD:11041000 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B IEP
ISO 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20300455 PMID:9828229 RGD:1598596 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 IEP RGD PMID:16572733 RGD:1598611 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 IEP RGD PMID:17285300 RGD:2301914 NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:105,734,992...105,815,982 		JBrowse link
G Ace angiotensin I converting enzyme IEP associated with Hemorrhage;protein:decreased activity:plasma (rat) RGD PMID:3028670 RGD:8142370 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Ache acetylcholinesterase ISO RGD PMID:17657467 RGD:5688055 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 IEP RGD PMID:11680626 RGD:1598729 NCBI chr 3:121,266,291...121,271,827
Ensembl chr 3:121,266,291...121,271,827 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 IEP protein:increased expression:plasma, spleen RGD PMID:23025351 RGD:9681752 NCBI chr11:38,418,565...38,427,384
Ensembl chr11:38,418,101...38,427,390 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing IEP associated with Obesity RGD PMID:23838384 RGD:8695926 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Adipor2 adiponectin receptor 2 severity IEP associated with obesity;mRNA:decreased expression:liver (rat) RGD PMID:23838384 RGD:8695926 NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:154,172,567...154,231,666 		JBrowse link
G Adra2a adrenoceptor alpha 2A onset IEP mRNA:increased expression:spleen RGD PMID:20302880 RGD:6480487 NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:263,065,278...263,069,871 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 IEP protein:decreased expression:kidney RGD PMID:16725227 RGD:6903849 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:116,913,656...116,918,745 		JBrowse link
G Ahr aryl hydrocarbon receptor severity ISO RGD PMID:24930766 RGD:39939032 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Akp3 alkaline phosphatase 3, intestine, not Mn requiring ISO RGD PMID:23569246 RGD:14349049 NCBI chr 9:95,252,581...95,256,616
Ensembl chr 9:95,248,840...95,256,616 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 IEP RGD PMID:22824368 RGD:38676479 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A IEP RGD PMID:16930621 RGD:1599054 NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15328337 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126 		JBrowse link
G Alpp alkaline phosphatase, placental ISO RGD PMID:23569246 RGD:14349049 NCBI chr 9:95,213,763...95,216,509
Ensembl chr 9:95,213,374...95,219,451 		JBrowse link
G Apoa1 apolipoprotein A1 treatment ISO
IDA 		RGD PMID:18593575 PMID:23227448 RGD:7241573, RGD:7241868 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729 		JBrowse link
G Apob apolipoprotein B IEP RGD PMID:16719989 RGD:1599165 NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814 		JBrowse link
G Apoe apolipoprotein E ISO rat model treated with human protein RGD PMID:9153287 RGD:6904216 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855 		JBrowse link
G Asl argininosuccinate lyase IEP RGD PMID:10652239 RGD:1599265 NCBI chr12:32,295,779...32,313,257
Ensembl chr12:32,295,633...32,317,261 		JBrowse link
G Ass1 argininosuccinate synthase 1 IEP RGD PMID:10652239 RGD:1599265 NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:35,144,999...35,194,627 		JBrowse link
G Atf2 activating transcription factor 2 treatment IEP
IDA 		protein:increased expression, increased activity:small intestine mucosa RGD PMID:21641970 PMID:24312512 RGD:5135029, RGD:10047418 NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator IEP mRNA:increased expression:diaphragm RGD PMID:23940949 RGD:10054120 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bche butyrylcholinesterase ISO RGD PMID:17657467 RGD:5688055 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760 		JBrowse link
G Bcl2 BCL2, apoptosis regulator IEP mRNA:decreased expression:diaphragm RGD PMID:23940949 RGD:10054120 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G C5ar1 complement C5a receptor 1 IEP mRNA:increased expression:lung RGD PMID:9272704 RGD:70679 NCBI chr 1:86,077,309...86,088,001 JBrowse link
G Casp1 caspase 1 IMP RGD PMID:17384935 RGD:2315892 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Casp3 caspase 3 IEP mRNA:increased expression:diaphragm RGD PMID:23940949 RGD:10054120 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 ISO RGD PMID:19168786 RGD:5684539 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp9 caspase 9 treatment IEP RGD PMID:23214195 RGD:10400903 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cbs cystathionine beta synthase severity ISO
IEP 		Protein:increased expression:spleen, lung (mouse)
mRNA:increased expression:liver (rat) 		RGD PMID:27748832 PMID:27748832 PMID:24702258 PMID:16100527 RGD:40903019, RGD:40903019, RGD:40903035, RGD:40903049 NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,709,395...9,734,066 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP protein:increased expression:plasma RGD PMID:19060786 RGD:2307004 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP protein:increased expression:plasma RGD PMID:16215387 RGD:2307171 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 ISO RGD PMID:17016504 RGD:5688178 NCBI chr 8:132,433,711...132,439,266
Ensembl chr 8:132,431,592...132,439,374 		JBrowse link
G Cd14 CD14 molecule IEP protein:increased expression:liver, endothelial cell of sinusoid RGD PMID:12046090 RGD:724637 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292 		JBrowse link
G Cd40 CD40 molecule ISO protein:decreased nitrosylation:macrophage RGD PMID:20473113 RGD:5490974 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta treatment IEP
ISO 		RGD PMID:15192048 PMID:14659593 RGD:1625687, RGD:40903034 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:76,000,754...76,186,734 		JBrowse link
G Cs citrate synthase IEP protein:increased expression:gastrocnemius RGD PMID:25674200 RGD:329337350 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938 		JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:9514298 RGD:11039535 NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 IEP protein:increased expression:atrium endocardium RGD PMID:19282612 RGD:4891965 NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 ISO mRNA:increased expression:multiple organs RGD PMID:9766630 RGD:5135254 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 ISO mRNA:increased expression:multiple organs RGD PMID:9766630 RGD:5135254 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 ISO mRNA:increased expression:multiple organs RGD PMID:9766630 RGD:5135254 NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,594,959...17,596,417 		JBrowse link
G Edn1 endothelin 1 IEP mRNA, protein:increased expression:liver (rat) RGD PMID:11206318 RGD:8662297 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Ep300 E1A binding protein p300 IEP associated with Kidney Reperfusion Injury; protein:altered localization:kidney (rat) RGD PMID:23936185 RGD:7257563 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574 		JBrowse link
G Ephx2 epoxide hydrolase 2 ISO RGD PMID:19154430 RGD:5688360 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:23214195 RGD:10400903 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725 		JBrowse link
G F12 coagulation factor XII IEP RGD PMID:11092686 RGD:7394782 NCBI chr17:9,212,819...9,220,664
Ensembl chr17:9,212,819...9,220,664 		JBrowse link
G F2 coagulation factor II, thrombin treatment
severity 		IDA
ISO
IEP 		associated with liver cirrhosis;protein:increased expression:blood plasma (human)
associated with liver cirrhosis;protein:increased expression:plasma (human) 		RGD PMID:21396682 PMID:10604885 PMID:7615203 PMID:10887118 PMID:9863491 More... RGD:5147765, RGD:40818436, RGD:14974253, RGD:40818427, RGD:14401592, RGD:10449434, RGD:6893482, RGD:5147779 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246 		JBrowse link
G F3 coagulation factor III, tissue factor treatment IDA
ISO 		associated with Protein C Deficiency RGD PMID:21396682 PMID:20858853 PMID:8956768 RGD:5147765, RGD:11341685, RGD:11340208 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369 		JBrowse link
G F5 coagulation factor V IEP RGD PMID:11092686 RGD:7394782 NCBI chr13:79,046,657...79,116,247
Ensembl chr13:79,046,448...79,116,247 		JBrowse link
G F7 coagulation factor VII treatment IEP
ISO 		RGD PMID:11092686 PMID:16378835 RGD:7394782, RGD:11041650 NCBI chr16:83,191,896...83,202,775
Ensembl chr16:83,191,914...83,202,738 		JBrowse link
G F8 coagulation factor VIII IEP RGD PMID:11092686 RGD:7394782 NCBI chr18:155,237...187,186
Ensembl chr18:155,309...186,683 		JBrowse link
G Fas Fas cell surface death receptor IEP mRNA, protein:increased expression:spleen (rat) RGD PMID:20428798 RGD:8662930 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Fga fibrinogen alpha chain treatment IDA RGD PMID:19295478 RGD:11040925 NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577 		JBrowse link
G Foxp3 forkhead box P3 IEP protein:increased expression:intestinal mucosa RGD PMID:19998507 RGD:38455980 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:17,580,380...17,595,894 		JBrowse link
G Gch1 GTP cyclohydrolase 1 treatment IEP mRNA:increased expression:lung
associated with liver cirrhosis 		RGD PMID:9388472 PMID:16845913 PMID:14647062 RGD:329961576, RGD:401793756, RGD:401700399 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:22,884,006...22,917,412 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration IEP RGD PMID:23073658 RGD:9685733 NCBI chr10:14,223,023...14,225,736
Ensembl chr10:14,223,023...14,225,935 		JBrowse link
G Ghr growth hormone receptor IEP mRNA:decreased expression:liver RGD PMID:12654216 PMID:12217886 RGD:2307380, RGD:625688 NCBI chr 2:54,269,066...54,532,595
Ensembl chr 2:54,270,206...54,532,331 		JBrowse link
G Gpt glutamic--pyruvic transaminase treatment IEP RGD PMID:25514429 RGD:401717525 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gsr glutathione-disulfide reductase treatment IEP RGD PMID:25469663 RGD:10401928 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Hmgb1 high mobility group box 1 IEP protein:increased expression:heart, serum RGD PMID:18503231 RGD:10402065 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Hmox1 heme oxygenase 1 treatment IEP RGD PMID:21396999 RGD:10755715 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hsf1 heat shock transcription factor 1 treatment IDA RGD PMID:25571843 RGD:10402404 NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 IEP
ISO 		mRNA, protein:increased expression:medulla oblongata
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:16741687 PMID:16675490 RGD:1624232 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP protein:increased expression:lung (rat) RGD PMID:19776691 RGD:4145502 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 ISO RGD PMID:24930766 PMID:28077574 RGD:39939032, RGD:39939117 NCBI chr16:74,133,259...74,145,328
Ensembl chr16:74,133,259...74,145,328 		JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 ISO RGD PMID:24930766 RGD:39939032 NCBI chr16:74,161,761...74,200,651
Ensembl chr16:74,161,774...74,200,650 		JBrowse link
G Ifng interferon gamma IEP protein:increased expression:serum: RGD PMID:9195172 RGD:10755747 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Igf1 insulin-like growth factor 1 IEP mRNA, protein:decreased expression:liver, serum RGD PMID:18492809 PMID:12217886 RGD:10402757, RGD:625688 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764 		JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit IEP RGD PMID:12217886 RGD:625688 NCBI chr10:14,397,076...14,408,439
Ensembl chr10:14,403,399...14,407,138 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 IEP RGD PMID:12217886 RGD:625688 NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 IEP mRNA, protein:decreased expression:liver, serum RGD PMID:18492809 RGD:10402757 NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 IEP RGD PMID:12217886 RGD:625688 NCBI chr 9:81,901,605...81,914,187
Ensembl chr 9:81,897,616...81,914,390 		JBrowse link
G Il10 interleukin 10 treatment IEP
ISO 		protein:increased expression:plasma RGD PMID:19302852 PMID:27943364 PMID:28664613 RGD:2311055, RGD:14975170, RGD:14975137 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il13 interleukin 13 treatment ISO RGD PMID:10674721 RGD:8549626 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il1a interleukin 1 alpha ISO
IEP 		protein:increased expression:plasma RGD PMID:9636192 PMID:22426124 RGD:6907109, RGD:7794786 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta IEP protein:increased expression:plasma RGD PMID:17201737 RGD:1626625 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment IEP
ISO 		mRNA:increased expression:lung, spleen, liver (rat) RGD PMID:1385928 PMID:8855299 RGD:8551846, RGD:11522760 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il6 interleukin 6 IDA
IEP 		associated with Diabetes Mellitus, Experimental; Protein:increased expression:extracellular space (rat)
protein:increased expression:plasma, pituitary, adrenal, spleen
protein:increased expression:serum (rat) 		RGD PMID:19449282 PMID:10235303 PMID:22227956 PMID:21396682 RGD:2307179, RGD:598148179, RGD:6893482, RGD:5147765 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 ISO mRNA, protein:increased expression:blood (human) RGD PMID:17982103 RGD:36049802 NCBI chr 7:57,538,522...57,600,166
Ensembl chr 7:57,539,557...57,598,706 		JBrowse link
G Irs1 insulin receptor substrate 1 ISO protein:increased tyrosine nitration, decreased tyrosine phosphorylation:skeletal muscle RGD PMID:21206533 RGD:6483008 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538 		JBrowse link
G Itga2b integrin subunit alpha 2b IMP RGD PMID:15280099 RGD:2316360 NCBI chr10:87,908,697...87,926,225
Ensembl chr10:87,908,697...87,925,833 		JBrowse link
G Itgb3 integrin subunit beta 3 IMP RGD PMID:15280099 RGD:2316360 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 ISO RGD PMID:22609006 RGD:6892951 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042 		JBrowse link
G Lbp lipopolysaccharide binding protein treatment IEP
ISO 		mRNA:increased expression:hepatocyte RGD PMID:8418776 PMID:8593028 PMID:16307218 RGD:9685191, RGD:9685196, RGD:9685193 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518 		JBrowse link
G Lcn2 lipocalin 2 ISO mRNA:increased expression:brain,liver RGD PMID:21943033 RGD:126779582 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Map2 microtubule-associated protein 2 ISO mRNA, protein:decreased expression:neuron RGD PMID:21421895 RGD:6483086 NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 treatment IEP
IDA 		protein:increased activity:small intestine mucosa RGD PMID:21641970 PMID:24312512 RGD:5135029, RGD:10047418 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEP protein:increased phophorylation:hippocampus (rat) RGD PMID:12207162 RGD:150340687 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mc4r melanocortin 4 receptor IEP mRNA:increased expression:paraventricular nucleus (rat) RGD PMID:21343543 RGD:6484214 NCBI chr18:62,689,798...62,691,685 JBrowse link
G Mif macrophage migration inhibitory factor IEP protein:increased expression:plasma RGD PMID:16601957 RGD:1641983 NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121 		JBrowse link
G Mir146a microRNA 146a treatment ISO miRNA:increased expression:spleen (mouse) RGD PMID:30867482 RGD:34888227 NCBI chr10:28,349,996...28,350,090 JBrowse link
G Mir155 microRNA 155 treatment ISO associated with familial hyperlipidemia RGD PMID:28970282 PMID:28264607 PMID:29079998 PMID:29979224 RGD:21079445, RGD:24922204, RGD:21081539, RGD:21081538 NCBI chr11:37,261,114...37,261,178
Ensembl chr11:37,261,114...37,261,178 		JBrowse link
G Mme membrane metallo-endopeptidase severity IMP RGD PMID:11078421 RGD:13801040 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463 		JBrowse link
G Mmp3 matrix metallopeptidase 3 IEP RGD PMID:17083784 RGD:2290426 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826 		JBrowse link
G Mt2 metallothionein 2 IEP mRNA:increased expression:liver (rat) RGD PMID:22100509 RGD:6483852 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709 		JBrowse link
G Mt3 metallothionein 3 IEP RGD PMID:12135776 RGD:10412330 NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming IEP RGD PMID:19099858 RGD:7349370 NCBI chr 1:206,225,775...206,261,280
Ensembl chr 1:206,229,035...206,261,280 		JBrowse link
G Myh6 myosin heavy chain 6 IEP RGD PMID:7874842 RGD:12792976 NCBI chr15:32,388,102...32,413,663
Ensembl chr15:32,387,487...32,411,333 		JBrowse link
G Myh7 myosin heavy chain 7 IEP RGD PMID:7874842 RGD:12792976 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 treatment IEP RGD PMID:26646455 RGD:42722616 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkbia NFKB inhibitor alpha exacerbates
treatment 		ISO RGD PMID:19098124 PMID:10229101 RGD:126908017, RGD:126928139 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos2 nitric oxide synthase 2 IEP
ISO
IDA 		mRNA, protein:increased expression:intestine
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:12620498 PMID:16787348 PMID:20519137 RGD:4891470, RGD:5147779 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 IEP protein:increased expression:aorta (rat) RGD PMID:10462376 RGD:7794732 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Npy neuropeptide Y treatment IDA RGD PMID:15342191 RGD:1580787 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IDA RGD PMID:15640646 RGD:4892561 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Otc ornithine transcarbamylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr  X:15,126,358...15,202,473
Ensembl chr  X:15,126,358...15,239,555 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 IEP RGD PMID:19268478 PMID:12217886 RGD:10427879, RGD:625688 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) IEP mRNA,protein:decreased expression,decreased activity:liver: RGD PMID:19268478 RGD:10427879 NCBI chr15:32,997,853...33,006,691
Ensembl chr15:32,997,834...33,016,864 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 IEP RGD PMID:16337011 RGD:6483567 NCBI chr 2:6,130,045...6,176,974
Ensembl chr 2:6,129,592...6,176,974 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 IEP RGD PMID:16337011 RGD:6483567 NCBI chr 3:151,333,938...151,636,628
Ensembl chr 3:151,333,234...151,638,849 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:22119535 RGD:6771174 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839 		JBrowse link
G Pf4 platelet factor 4 treatment IEP RGD PMID:20601223 RGD:329901905 NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,582,477...17,583,392 		JBrowse link
G Pgf placental growth factor ISO protein:increased expression:multiple RGD PMID:16702604 RGD:6483601 NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:110,547,153...110,557,747 		JBrowse link
G Pla2g7 phospholipase A2 group VII IEP protein:increased expression: : RGD PMID:10748027 RGD:7248791 NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:24,859,502...24,901,747 		JBrowse link
G Plat plasminogen activator, tissue type treatment ISO RGD PMID:9091588 RGD:11541073 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma IEP protein:increased expression:small intestine mucosa RGD PMID:21641970 RGD:5135029 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 ISO mRNA:decreased expression:epididymal fat pad RGD PMID:20421294 RGD:6484543 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO protein:increased expression:liver, mitochondrion (mouse) RGD PMID:28615325 RGD:13432559 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:18205901 PMID:23170801 RGD:11100030, RGD:11100034 NCBI chr18:24,038,596...24,049,061
Ensembl chr18:24,038,597...24,048,964 		JBrowse link
G Ptafr platelet-activating factor receptor treatment IMP RGD PMID:2178565 RGD:10041063 NCBI chr 5:150,049,322...150,079,060
Ensembl chr 5:150,049,460...150,079,408 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IEP protein:increased expression:paraventricular hypothalamic nucleus parvicellular division (rat) RGD PMID:11058222 RGD:10043329 NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:56,062,890...56,074,135 		JBrowse link
G Ptgis prostaglandin I2 synthase treatment IMP RGD PMID:11076704 RGD:401960076 NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IEP RGD PMID:21641970 RGD:5135029 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ren renin ISO
IEP 		protein:increased activity:blood plasma (mouse)
protein:increased activity:blood plasma (rat) 		RGD PMID:30027346 PMID:16512638 RGD:125097481, RGD:125097499 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Serpinc1 serpin family C member 1 treatment ISO
IDA
IEP 		RGD PMID:16457847 PMID:21396682 PMID:20519137 PMID:15995859 RGD:1599326, RGD:5147765, RGD:5147779, RGD:1599332 NCBI chr13:75,790,558...75,804,826
Ensembl chr13:75,790,546...75,817,643 		JBrowse link
G Serpine1 serpin family E member 1 treatment IEP
IDA 		RGD PMID:21396682 PMID:25396762 RGD:5147765, RGD:10449434 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Serpinf1 serpin family F member 1 ISO protein:increased expression:plasma (human) RGD PMID:12386642 RGD:36174005 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,748,506...60,760,898 		JBrowse link
G Serping1 serpin family G member 1 treatment ISO RGD PMID:18652771 RGD:8661643 NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:90,249,423...90,258,717 		JBrowse link
G Slc18a3 solute carrier family 18 member A3 IEP protein:decreased expression:parietal cortex RGD PMID:17306796 RGD:5686693 NCBI chr16:7,719,953...7,722,814 JBrowse link
G Slc22a1 solute carrier family 22 member 1 treatment IDA RGD PMID:18313662 RGD:7243881 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 treatment IDA RGD PMID:18313662 RGD:7243881 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Slc38a3 solute carrier family 38, member 3 IEP RGD PMID:20036385 RGD:9999227 NCBI chr 8:117,202,534...117,220,310
Ensembl chr 8:117,202,536...117,218,630 		JBrowse link
G Slc38a5 solute carrier family 38, member 5 IEP RGD PMID:20036385 RGD:9999227 NCBI chr  X:16,885,701...16,894,470
Ensembl chr  X:16,885,701...16,894,470 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 IEP RGD PMID:26337286 RGD:151361133 NCBI chr19:66,843,808...66,872,412
Ensembl chr19:66,843,808...66,872,412 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor IEP RGD PMID:25466948 RGD:9999425 NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO mRNA:increased expression:liver, skeletal muscle RGD PMID:15169905 RGD:2298923 NCBI chr10:5,389,574...5,391,265
Ensembl chr10:5,389,334...5,391,847 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO
IEP 		mRNA:increased expression:liver, skeletal muscle RGD PMID:15169905 PMID:12217886 RGD:2298923, RGD:625688 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sparc secreted protein acidic and cysteine rich IEP mRNA, protein:decreased expression:kidney RGD PMID:10703670 RGD:2300026 NCBI chr10:40,017,065...40,038,816
Ensembl chr10:40,017,075...40,039,268 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B IDA protein:decreased tyrosine phosphorylation:liver RGD PMID:17327369 RGD:1601383 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990 		JBrowse link
G Tbxa2r thromboxane A2 receptor IDA
IMP 		RGD PMID:15647606 PMID:2580129 RGD:1601450, RGD:11059531 NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:9,034,108...9,038,905 		JBrowse link
G Tbxas1 thromboxane A synthase 1 IDA RGD PMID:15647606 RGD:1601450 NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:68,631,838...68,803,969 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase severity ISO RGD PMID:24930766 RGD:39939032 NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:169,567,654...169,585,586 		JBrowse link
G Tfpi tissue factor pathway inhibitor treatment ISO RGD PMID:17537762 RGD:11062086 NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:89,939,868...89,980,742 		JBrowse link
G Thbd thrombomodulin IEP
ISO 		mRNA:decreased expression:endothelial cell RGD PMID:12611420 PMID:20348393 PMID:19487933 RGD:1601652, RGD:5685037, RGD:5684988 NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:156,306,632...156,320,582 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 IEP RGD PMID:17083784 RGD:2290426 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547 		JBrowse link
G Tlr2 toll-like receptor 2 treatment IDA
ISO 		associated with liver cirrhosis RGD PMID:22172266 PMID:12610323 RGD:7241094, RGD:597538466 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tlr4 toll-like receptor 4 treatment
disease_progression 		IDA
ISO 		mRNA:increased expression:liver: RGD PMID:22172266 PMID:23977376 PMID:23977376 RGD:7241094, RGD:14697731, RGD:14697731 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor treatment IEP
ISO
IDA 		protein:increased expression:plasma
XCO:0000822 JTE-607
associated with liver cirrhosis
protein:increased expression:plasma (rat) 		RGD PMID:17324147 PMID:10493164 PMID:15242491 PMID:18078960 PMID:8283134 More... RGD:4891465, RGD:40903016, RGD:38501090, RGD:15023464, RGD:14995443, RGD:14995427, RGD:5147765, RGD:5147779 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 treatment ISO RGD PMID:21507332 PMID:15585833 RGD:126925982, RGD:126928122 NCBI chr 9:20,259,227...20,276,879
Ensembl chr 9:20,261,408...20,276,892 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 IEP mRNA:increased expression:brain: RGD PMID:20061033 RGD:7240511 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vwf von Willebrand factor IEP protein:increased expression:endothelial cell: RGD PMID:2650559 RGD:11079230 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757 		JBrowse link
endotoxin shock term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gch1 GTP cyclohydrolase 1 treatment IDA RGD PMID:8602831 RGD:329961578 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:22,884,006...22,917,412 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A treatment IMP RGD PMID:19318092 RGD:401901206 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619 		JBrowse link
Fetal Inflammatory Response Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 ISO associated with Premature Birth; RGD PMID:24832219 RGD:12801490 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
Fungemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule treatment ISO RGD PMID:23663657 RGD:40818234 NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951 		JBrowse link
G Pdcd1 programmed cell death 1 treatment ISO protein:increased expression:CD4 Tcell, CD8 Tcell: RGD PMID:23663657 PMID:23663657 RGD:40818234, RGD:40818234 NCBI chr 9:101,866,124...101,879,278
Ensembl chr 9:101,866,126...101,879,270 		JBrowse link
malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A treatment
susceptibility 		ISO DNA:SNP: :c3435C>T(human)
DNA:hypermethylation:promoter
DNA:SNPs,haplotype: :rs2032582, rs1128503 (human)
DNA:haplotype: :1236C>T, 2677G>T,3435C>T (human) 		RGD PMID:28934955 PMID:19331170 PMID:28422980 PMID:17015054 RGD:39456120, RGD:39457680, RGD:39457679, RGD:39456123 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Ace angiotensin I converting enzyme severity ISO RGD PMID:31234939 RGD:39939120 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Ackr1 atypical chemokine receptor 1 ISO ClinVar Annotator: match by term: Plasmodium vivax, resistance to
CTD Direct Evidence: marker/mechanism 		ClinVar
CTD
OMIM		 PMID:7663520 PMID:8547665 PMID:8651934 PMID:10570183 PMID:10791881 More... NCBI chr13:88,314,735...88,316,354
Ensembl chr13:88,293,188...88,317,807 		JBrowse link
G Aicda activation-induced cytidine deaminase ISO protein:increased expression: B cell RGD PMID:27980783 RGD:30310233 NCBI chr 4:157,446,120...157,455,958
Ensembl chr 4:157,444,697...157,456,356 		JBrowse link
G Ank1 ankyrin 1 ISS OMIM:609148 | OMIM:611162 MouseDO NCBI chr16:75,578,824...75,757,464
Ensembl chr16:75,578,824...75,757,464 		JBrowse link
G Apoe apolipoprotein E ISO DNA:missense mutations:cds:p.C112R, p.C158R (human) RGD PMID:24116184 RGD:11039486 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855 		JBrowse link
G Aqp4 aquaporin 4 ISS OMIM:609148 | OMIM:611162 MouseDO NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098 		JBrowse link
G Cbs cystathionine beta synthase susceptibility ISO DNA:insertion:cds: (844ins68) (human) RGD PMID:27198213 RGD:40903062 NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,709,395...9,734,066 		JBrowse link
G Cd163 CD163 molecule exacerbates
severity 		ISO protein:increased expression:blood plasma (human)
protein:altered expression:blood plasma (human) 		RGD PMID:22290142 PMID:18632918 RGD:127285797, RGD:149735529 NCBI chr 4:158,770,751...158,804,146
Ensembl chr 4:158,770,749...158,804,146 		JBrowse link
G Cd1d1 CD1d1 molecule ameliorates
exacerbates 		ISO RGD PMID:12938235 PMID:24703850 RGD:127345117, RGD:127345121 NCBI chr 2:174,721,522...174,725,029
Ensembl chr 2:174,721,522...174,725,029 		JBrowse link
G Cd36 CD36 molecule ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Malaria, cerebral, susceptibility to | ClinVar Annotator: match by term: Malaria, susceptibility to 		CTD
OMIM
ClinVar		 PMID:10890433 PMID:18305138 PMID:19403559 PMID:25741868 PMID:28960434 More... NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Cd40 CD40 molecule severity ISO RGD PMID:11485931 RGD:11352239 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cd40lg CD40 ligand severity ISO RGD PMID:11485931 RGD:11352239 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:140,164,302...140,176,475 		JBrowse link
G Cish cytokine inducible SH2-containing protein susceptibility ISO ClinVar Annotator: match by term: Malaria, susceptibility to
CTD Direct Evidence: marker/mechanism 		ClinVar
CTD
OMIM		 PMID:20484391 NCBI chr 8:116,850,969...116,855,917
Ensembl chr 8:116,850,773...116,855,986 		JBrowse link
G Crp C-reactive protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:8730300 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 treatment
disease_progression 		ISO RGD PMID:28892065 PMID:28892065 RGD:38455986, RGD:38455986 NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:69,813,265...69,819,973 		JBrowse link
G Ephb2 Eph receptor B2 ISO mRNA:increased expression:liver RGD PMID:25784101 RGD:127285023 NCBI chr 5:154,179,065...154,360,459
Ensembl chr 5:154,179,065...154,360,615 		JBrowse link
G Ephb3 Eph receptor B3 IEP RGD PMID:25784101 RGD:127285023 NCBI chr11:93,345,098...93,363,775
Ensembl chr11:93,345,098...93,363,775 		JBrowse link
G Ephb6 Eph receptor B6 ISO RGD PMID:25784101 RGD:127285023 NCBI chr 4:71,458,632...71,473,889
Ensembl chr 4:71,458,971...71,476,659 		JBrowse link
G Fcgr2a Fc gamma receptor 2A susceptibility ISO DNA:missense mutation:cds:p.H131R (human)
ClinVar Annotator: match by term: Malaria, severe, susceptibility to
CTD Direct Evidence: marker/mechanism 		ClinVar
CTD
OMIM
RGD		 PMID:8636449 PMID:9843982 PMID:10675363 PMID:15367919 PMID:19915573 More... RGD:5147921 NCBI chr13:85,813,516...85,830,269
Ensembl chr13:85,855,437...85,864,394
Ensembl chr13:85,855,437...85,864,394 		JBrowse link
G Fcgr2b Fc gamma receptor 2B susceptibility ISO
ISS 		ClinVar Annotator: match by term: Malaria, resistance to
CTD Direct Evidence: marker/mechanism 		ClinVar
OMIM
MouseDO
CTD		 PMID:12115230 PMID:15459183 PMID:16115811 PMID:16170323 PMID:17435165 More... NCBI chr13:85,725,897...85,740,517
Ensembl chr13:85,725,897...85,740,517 		JBrowse link
G Foxp3 forkhead box P3 disease_progression ISO RGD PMID:19338000 PMID:16169501 RGD:38455985, RGD:38455992 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:17,580,380...17,595,894 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase susceptibility
severity 		ISO DNA:SNPs: :multiple
ClinVar Annotator: match by term: Malaria, susceptibility to
CTD Direct Evidence: marker/mechanism
DNA:point mutation:cds:c.968T>C (human) 		ClinVar
CTD
OMIM
RGD		 PMID:5448 PMID:16832 PMID:511159 PMID:736032 PMID:853376 More... RGD:10449111, RGD:10449115 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144 		JBrowse link
G Gypa glycophorin A ISO CTD Direct Evidence: marker/mechanism OMIM
CTD		 NCBI chr19:44,354,669...44,370,304
Ensembl chr19:44,354,706...44,370,291 		JBrowse link
G Gypc glycophorin C ISO ClinVar Annotator: match by term: GYPC-related condition | ClinVar Annotator: match by term: Malaria, resistance to
CTD Direct Evidence: marker/mechanism 		OMIM
ClinVar
CTD		 PMID:1991173 PMID:5011657 PMID:8157284 PMID:11719395 PMID:12469115 More... NCBI chr18:24,434,921...24,467,592
Ensembl chr18:24,434,922...24,440,053 		JBrowse link
G Hbb hemoglobin subunit beta resistance ISO ClinVar Annotator: match by term: Malaria, resistance to | ClinVar Annotator: match by term: Malaria, susceptibility to
CTD Direct Evidence: marker/mechanism 		ClinVar
CTD
OMIM
RGD		 PMID:14973 PMID:81926 PMID:88735 PMID:750553 PMID:893136 More... RGD:1600894 NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:167,630,245...167,663,873 		JBrowse link
G Hmox1 heme oxygenase 1 ISS OMIM:609148 | OMIM:611162 MouseDO NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hp haptoglobin ISO CTD Direct Evidence: marker/mechanism CTD PMID:8730300 PMID:16597321 NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518 		JBrowse link
G Icam1 intercellular adhesion molecule 1 susceptibility ISO
ISS 		ClinVar Annotator: match by term: ICAM1-related condition | ClinVar Annotator: match by term: Malaria, cerebral, susceptibility to | ClinVar Annotator: match by term: Malaria, susceptibility to
CTD Direct Evidence: marker/mechanism 		OMIM
ClinVar
MouseDO
CTD		 PMID:9259284 PMID:9861406 PMID:10417733 PMID:10699175 PMID:23609612 More... NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifng interferon gamma ISS OMIM:609148 | OMIM:611162 MouseDO NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO ClinVar Annotator: match by term: Malaria, susceptibility to ClinVar PMID:1945893 PMID:3198117 PMID:6805883 PMID:7803800 PMID:8244337 More... NCBI chr  X:157,358,279...157,397,563
Ensembl chr  X:157,367,639...157,392,757 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 ISO RGD PMID:28359899 RGD:39938859 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891 		JBrowse link
G Il21 interleukin 21 exacerbates ISO RGD PMID:25763578 RGD:127285358 NCBI chr 2:122,045,240...122,055,142
Ensembl chr 2:122,045,240...122,055,142 		JBrowse link
G Il27 interleukin 27 ameliorates ISO RGD PMID:24522137 PMID:26968425 RGD:126790512, RGD:11530371 NCBI chr 1:190,603,684...190,609,292
Ensembl chr 1:190,603,522...190,609,258 		JBrowse link
G Il33 interleukin 33 ISO protein:increased expression:serum: RGD PMID:28359899 RGD:39938859 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901 		JBrowse link
G Kir3dl1 killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 severity ISO DNA:deletion:cds RGD PMID:21889618 RGD:38676475 NCBI chr 1:78,756,035...78,796,961
Ensembl chr 1:78,757,394...78,796,715 		JBrowse link
G Ltbr lymphotoxin beta receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15788153 NCBI chr 4:159,795,115...159,801,571
Ensembl chr 4:159,795,115...159,807,296 		JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 ISO ClinVar Annotator: match by term: Malaria, susceptibility to ClinVar PMID:20484391 NCBI chr 8:116,808,429...116,842,228
Ensembl chr 8:116,808,429...116,842,228 		JBrowse link
G Mir122 microRNA 122 treatment ISO RGD PMID:28123381 RGD:35673288 NCBI chr18:61,028,817...61,028,901 JBrowse link
G Mir142 microRNA 142 treatment ISO RGD PMID:28123381 RGD:35673288 NCBI chr10:73,055,104...73,055,190
Ensembl chr10:73,055,097...73,055,207 		JBrowse link
G Mirlet7a1 microRNA let-7a-1 treatment ISO RGD PMID:28123381 RGD:35673288 NCBI chr17:16,320,133...16,320,226
Ensembl chr17:16,320,135...16,320,234 		JBrowse link
G Mirlet7c1 microRNA let-7c-1 treatment ISO RGD PMID:28123381 RGD:35673288 NCBI chr11:29,688,112...29,688,205
Ensembl chr11:29,688,107...29,688,214 		JBrowse link
G Mki67 marker of proliferation Ki-67 ISO associated with Lung Neoplasms RGD PMID:21931708 RGD:6483517 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Ncr3 natural cytotoxicity triggering receptor 3 susceptibility ISO ClinVar Annotator: match by term: Malaria, severe, susceptibility to | ClinVar Annotator: match by term: NCR3-related condition
CTD Direct Evidence: marker/mechanism 		ClinVar
CTD
OMIM		 PMID:17208487 NCBI chr20:3,642,912...3,648,425
Ensembl chr20:3,642,912...3,644,188 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO ClinVar Annotator: match by term: Malaria, resistance to | ClinVar Annotator: match by term: Malaria, severe, resistance to | ClinVar Annotator: match by term: Malaria, susceptibility to | ClinVar Annotator: match by term: NOS2-related condition
CTD Direct Evidence: marker/mechanism 		OMIM
ClinVar
CTD		 PMID:9457101 PMID:12433515 PMID:25741868 PMID:28492532 PMID:31995689 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Pklr pyruvate kinase L/R susceptibility ISO
ISS 		DNA:mutations, haplotype:multiple (human)
OMIM:609148 | OMIM:611162
DNA:missense mutation:cds:p.I90N (mouse) 		MouseDO
RGD		 PMID:20377593 PMID:14595440 RGD:11535999, RGD:11537407 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644 		JBrowse link
G Prf1 perforin 1 ISO RGD PMID:21525386 RGD:6482803 NCBI chr20:29,789,040...29,794,550
Ensembl chr20:29,788,972...29,795,124 		JBrowse link
G Procr protein C receptor disease_progression ISO RGD PMID:27671831 RGD:126848795 NCBI chr 3:164,714,727...164,718,994
Ensembl chr 3:164,711,636...164,718,989 		JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 ISO ClinVar Annotator: match by term: Malaria, susceptibility to ClinVar PMID:25741868 NCBI chr 7:133,860,901...134,034,809
Ensembl chr 7:133,861,227...134,030,026 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 ISO DNA:SNP::g.80G>A (human) RGD PMID:27198213 RGD:40903062 NCBI chr20:11,583,928...11,601,959
Ensembl chr20:11,583,929...11,601,488 		JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Malaria, cerebral, resistance to | ClinVar Annotator: match by term: Malaria, susceptibility to 		CTD
ClinVar		 PMID:1378323 PMID:1722314 PMID:1737855 PMID:2146504 PMID:4116984 More... NCBI chr10:87,807,010...87,823,274
Ensembl chr10:87,807,013...87,823,258 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:16552072 RGD:1581333 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Tbx21 T-box transcription factor 21 ISO RGD PMID:19338000 RGD:38455985 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,578,751...82,595,253 		JBrowse link
G Tirap TIR domain containing adaptor protein ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Malaria, resistance to 		CTD
OMIM
ClinVar		 PMID:16991088 PMID:17322885 PMID:18305471 PMID:25741868 NCBI chr 8:41,789,557...41,805,903
Ensembl chr 8:41,791,878...41,796,312 		JBrowse link
G Tnf tumor necrosis factor susceptibility ISO DNA:polymorphism:promoter:-376G>A
ClinVar Annotator: match by term: Malaria, cerebral, susceptibility to
CTD Direct Evidence: marker/mechanism 		OMIM
ClinVar
CTD
RGD		 PMID:8056188 PMID:9818939 PMID:10369255 PMID:10450718 PMID:11261930 More... RGD:1624967 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 severity ISO DNA:SNP: :rs2234237A>T (human) RGD PMID:27671831 RGD:126848795 NCBI chr 9:20,259,227...20,276,879
Ensembl chr 9:20,261,408...20,276,892 		JBrowse link
G Tslp thymic stromal lymphopoietin ISO mRNA:altered expression:multiple (mouse) RGD PMID:28955823 RGD:38596344 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,720,257...24,728,420 		JBrowse link
Malarial Anemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcgr3a Fc gamma receptor 3A severity
susceptibility 		ISO DNA:polymorphism: :p.F176V (human) RGD PMID:20231419 PMID:23045477 RGD:11040771, RGD:11344971 NCBI chr13:85,782,636...85,792,656
Ensembl chr13:85,782,490...85,792,651 		JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) severity ISO DNA:snp:promoter:g.-5699T>C (human) RGD PMID:16960783 RGD:10450507 NCBI chr10:87,807,010...87,823,274
Ensembl chr10:87,807,013...87,823,258 		JBrowse link
G Tlr9 toll-like receptor 9 susceptibility ISO DNA:SNP:promoter:g.-1237T>C (rs5743836) (human) RGD PMID:23045477 RGD:11344971 NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:115,742,889...115,750,148 		JBrowse link
Neonatal Sepsis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camp cathelicidin antimicrobial peptide ameliorates ISO RGD PMID:15645239 RGD:458925287 NCBI chr 8:118,720,184...118,721,998
Ensembl chr 8:118,720,184...118,721,998 		JBrowse link
G Crp C-reactive protein treatment IEP RGD PMID:15645239 RGD:458925287 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514 		JBrowse link
G Il27 interleukin 27 ISO protein:increased expression:blood serum (mouse)
protien:increased expression:blood serum (human) 		RGD PMID:31818960 PMID:22766719 RGD:126790524, RGD:126790543 NCBI chr 1:190,603,684...190,609,292
Ensembl chr 1:190,603,522...190,609,258 		JBrowse link
G Pla2g2a phospholipase A2 group IIA susceptibility ISO DNA:SNP:enhancer: (rs1891320) (human) RGD PMID:20463618 RGD:6482720 NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297 		JBrowse link
Plasmodium falciparum malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase susceptibility ISO DNA:SNPs,haplotype:multiple RGD PMID:18003641 RGD:39938831 NCBI chr 3:30,560,172...30,604,758 JBrowse link
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 ISO protein:decreased activity:plasma (human) RGD PMID:20062916 RGD:10449041 NCBI chr 3:30,697,354...30,736,539
Ensembl chr 3:30,697,942...30,736,540 		JBrowse link
G Bsg basigin ISO CTD Direct Evidence: therapeutic CTD PMID:22080952 PMID:26195724 NCBI chr 7:10,643,788...10,651,005
Ensembl chr 7:10,643,789...10,651,005 		JBrowse link
G Cast calpastatin ISO protein:alter localization:erythrocyte RGD PMID:17359359 RGD:5509812 NCBI chr 2:5,707,633...5,817,213
Ensembl chr 2:5,707,640...5,817,180 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 ISO mRNA, protein:increased expression:blood, RGD PMID:15972509 RGD:5683898 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722 		JBrowse link
G Clec11a C-type lectin domain containing 11A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19884328 NCBI chr 1:103,938,029...103,941,170
Ensembl chr 1:103,935,185...103,946,784 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 treatment ISO DNA:polymorphisms:: RGD PMID:10471063 RGD:124713538 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Fas Fas cell surface death receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625619 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Fcgr2a Fc gamma receptor 2A severity ISO DNA:missense mutation:cds:p.R131H (rs1801274) (human) RGD PMID:18194515 RGD:5147927 NCBI chr13:85,813,516...85,830,269
Ensembl chr13:85,855,437...85,864,394
Ensembl chr13:85,855,437...85,864,394 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase severity ISO DNA:missense mutation:cds:202G>A (p.V68M) (human) RGD PMID:24943486 RGD:10449113 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 severity ISO RGD PMID:19635899 RGD:10450848 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Hbb hemoglobin subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:20305663 NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:167,630,245...167,663,873 		JBrowse link
G Hp haptoglobin severity ISO DNA:missense mutation:cds:p.K54E (human) RGD PMID:24478401 RGD:11041793 NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518 		JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:plasma RGD PMID:21985368 RGD:5684362 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Mbl2 mannose binding lectin 2 susceptibility ISO DNA:haplotype:exon: RGD PMID:18396436 RGD:11530064 NCBI chr 1:237,429,873...237,465,567
Ensembl chr 1:237,429,973...237,437,546 		JBrowse link
G RT1-Bb RT1 class II, locus Bb susceptibility ISO DNA:polymorphism:cds:HLA-DQB1*0501 (human) RGD PMID:11076705 RGD:11041780 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118 		JBrowse link
G Tnf tumor necrosis factor severity ISO protein:increased expression:plasma RGD PMID:1984482 RGD:10450571 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Plasmodium vivax malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ackr1 atypical chemokine receptor 1 ISO ClinVar Annotator: match by term: ACKR1-related condition | ClinVar Annotator: match by term: Resistance to Plasmodium vivax infection OMIM
ClinVar		 PMID:7663520 PMID:7669660 PMID:7705836 PMID:8547665 PMID:8651934 More... NCBI chr13:88,314,735...88,316,354
Ensembl chr13:88,293,188...88,317,807 		JBrowse link
Pregnancy-associated Malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO RGD PMID:24717969 RGD:11041890 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Mir146a microRNA 146a susceptibility ISO miRNA:SNP: (rs2910164) (human) RGD PMID:30642347 RGD:126925184 NCBI chr10:28,349,996...28,350,090 JBrowse link
Sepsis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IEP mRNA:increased expression:liver RGD PMID:9843780 PMID:15167684 RGD:1598509, RGD:10046033 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:156,569,860...156,619,868 		JBrowse link
G Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase severity ISO DNA:polymorphism:cds:allele A (human) RGD PMID:4375858 RGD:39938844 NCBI chr 3:30,560,172...30,604,758 JBrowse link
G Ace angiotensin I converting enzyme susceptibility ISO DNA:insertion/deletion:intron: RGD PMID:19143971 RGD:40400706 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing IEP
ISO 		mRNA, protein:decreasedexpression:serum, omental fat pad: RGD PMID:16488436 PMID:19481767 PMID:21962804 RGD:1599144, RGD:5686835, RGD:5686408 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Adm adrenomedullin treatment IEP
ISO 		protein:increased expression:plasma:
CTD Direct Evidence: marker/mechanism
associated with Jaundice,Obstructive; 		CTD
RGD		 PMID:14766677 PMID:20132852 PMID:19009024 PMID:20132852 RGD:7364952, RGD:7364986, RGD:7364952 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371 		JBrowse link
G Adora2a adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:27757725 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802 		JBrowse link
G Adora2b adenosine A2B receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:27757725 NCBI chr10:47,439,712...47,456,092
Ensembl chr10:47,439,701...47,456,091 		JBrowse link
G Adra2a adrenoceptor alpha 2A disease_progression IMP RGD PMID:19894027 RGD:6480483 NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:263,065,278...263,069,871 		JBrowse link
G Adrb2 adrenoceptor beta 2 IDA
IEP 		mRNA,protein:decreased expression:liver: RGD PMID:16603198 PMID:10409266 RGD:1598745, RGD:8548498 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803 		JBrowse link
G Adrb3 adrenoceptor beta 3 ISO mRNA, protein:increased expression:heart left ventricle (human) RGD PMID:17999941 RGD:2292119 NCBI chr16:71,544,603...71,547,410
Ensembl chr16:71,542,567...71,547,420 		JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment IMP RGD PMID:19623040 RGD:10402067 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 IEP mRNA:increased expression:duodenum, jejunum, ileum (rat) RGD PMID:12627002 RGD:4144178 NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642 		JBrowse link
G Alb albumin disease_progression ISO protein:decreased expression:serum: RGD PMID:22801198 RGD:11036079 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member treatment IEP associated with heat shock treatment;protein:altered expression, altered phosphorylation:liver, mitochondria (rat) RGD PMID:17607160 RGD:15036802 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219 		JBrowse link
G Angpt1 angiopoietin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:16005988 NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696 		JBrowse link
G Apoa1 apolipoprotein A1 treatment IDA RGD PMID:19561306 RGD:7241869 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729 		JBrowse link
G Arg2 arginase 2 IEP protein:decreased expression:lung RGD PMID:9635249 RGD:1626297 NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:103,668,988...103,694,375 		JBrowse link
G Atm ATM serine/threonine kinase treatment ISO RGD PMID:24184056 RGD:126781746 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 IEP RGD PMID:28446393 RGD:13782063 NCBI chr 1:190,457,198...190,475,410
Ensembl chr 1:190,457,198...190,475,423 		JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase IEP RGD PMID:7575455 RGD:69770 NCBI chr 5:68,647,166...68,656,137
Ensembl chr 5:68,646,203...68,656,181 		JBrowse link
G Bad BCL2-associated agonist of cell death treatment IEP
IDA 		protein:increased localization:mitochondrion RGD PMID:24011917 PMID:22683079 RGD:10053647, RGD:10053707 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G C3 complement C3 IEP
ISO 		protein:increased expression:liver
mRNA:increased expression:kidney 		RGD PMID:3339873 PMID:24154627 RGD:7411622, RGD:11040886 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339 		JBrowse link
G C5 complement C5 IEP
IDA 		protein:increased activation:plasma RGD PMID:18648551 PMID:14688199 RGD:5130170, RGD:1600599 NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:38,668,174...38,759,468 		JBrowse link
G C5ar1 complement C5a receptor 1 disease_progression IEP
IMP 		RGD PMID:12897064 PMID:18648551 RGD:5130176, RGD:5130170 NCBI chr 1:86,077,309...86,088,001 JBrowse link
G C6 complement C6 severity IAGP RGD PMID:15638131 RGD:1600672 NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:55,573,653...55,649,120 		JBrowse link
G Cacna1s calcium voltage-gated channel subunit alpha1 S IEP protein:decreased expression:diaphragmaticus muscle RGD PMID:28044347 RGD:329849111 NCBI chr13:50,045,668...50,115,903
Ensembl chr13:50,045,668...50,115,903 		JBrowse link
G Camp cathelicidin antimicrobial peptide IMP RGD PMID:17142779 RGD:2316243 NCBI chr 8:118,720,184...118,721,998
Ensembl chr 8:118,720,184...118,721,998 		JBrowse link
G Casp3 caspase 3 treatment IEP
ISO 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16003065 PMID:32062619 PMID:29180187 RGD:13782295 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp6 caspase 6 IDA protein:increased activity:thymus, T cell RGD PMID:11086028 RGD:2301332 NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726 		JBrowse link
G Casp8 caspase 8 treatment IEP RGD PMID:18570579 PMID:29180187 RGD:2311435, RGD:13782295 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 treatment IEP RGD PMID:29180187 RGD:13782295 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cast calpastatin IEP RGD PMID:15563579 RGD:5683871 NCBI chr 2:5,707,633...5,817,213
Ensembl chr 2:5,707,640...5,817,180 		JBrowse link
G Cat catalase severity IEP RGD PMID:15836852 RGD:9068893 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cbs cystathionine beta synthase susceptibility ISO DNA:SNP:intron (rs6586282, rs34758144) (human) RGD PMID:26508567 RGD:40903018 NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,709,395...9,734,066 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 IEP RGD PMID:21652218 RGD:7248417 NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,525,862...67,530,575 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP mRNA:increased expression:ileum RGD PMID:19111613 RGD:2307002 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 severity ISO RGD PMID:21208283 RGD:5683911 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP protein:increased secretion:plasma (rat) RGD PMID:18290317 RGD:4890036 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Cd163 CD163 molecule ISO protein:increased expression:blood serum, CD-14 positive monocyte (human) RGD PMID:24637679 RGD:127285802 NCBI chr 4:158,770,751...158,804,146
Ensembl chr 4:158,770,749...158,804,146 		JBrowse link
G Cd1d1 CD1d1 molecule treatment ISO RGD PMID:14572776 RGD:127345103 NCBI chr 2:174,721,522...174,725,029
Ensembl chr 2:174,721,522...174,725,029 		JBrowse link
G Cd209a CD209a molecule ISO RGD PMID:23254286 RGD:39938991 NCBI chr12:1,822,663...1,828,246
Ensembl chr12:6,620,541...6,626,124 		JBrowse link
G Cd274 CD274 molecule disease_progression ISO protein:increased expression:monocyte
protein:increased expression:B cell,CD4T cell 		RGD PMID:30595665 PMID:27156867 PMID:29702526 PMID:29661225 RGD:40818235, RGD:41412183, RGD:40822808, RGD:40818424 NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951 		JBrowse link
G Cd28 Cd28 molecule severity ISO Higher soluble CD28 in human patients that died RGD PMID:17989345 RGD:5131622 NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:69,545,326...69,689,192 		JBrowse link
G Cd36 CD36 molecule ISO RGD PMID:22327076 RGD:6893490 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Cd40 CD40 molecule ISO protein:decreased nitrosylation:monocyte RGD PMID:20473113 RGD:5490974 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cd40lg CD40 ligand IEP mRNA:increased expression:heart (rat) RGD PMID:20933523 RGD:11352671 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:140,164,302...140,176,475 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A IEP RGD PMID:10451498 RGD:10043817 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta IEP protein:increased expression:skeletal muscle RGD PMID:11792653 RGD:625506 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta IEP protein:increased expression:skeletal muscle RGD PMID:11792653 RGD:625506 NCBI chr11:98,268,856...98,269,994
Ensembl chr11:98,265,651...98,280,824 		JBrowse link
G Cfb complement factor B treatment ISO RGD PMID:24154627 RGD:11040886 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740 		JBrowse link
G Cfh complement factor H treatment IEP
ISO 		protein:decreased expression:plasma:
associated with Jaundice,Obstructive; 		RGD PMID:20132852 PMID:19009024 PMID:20132852 RGD:7364952, RGD:7364986, RGD:7364952 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:54,062,531...54,164,532 		JBrowse link
G Cpb2 carboxypeptidase B2 IEP protein:increased activity:plasma: RGD PMID:15497025 RGD:2313648 NCBI chr15:56,967,128...57,015,964
Ensembl chr15:56,966,839...57,015,962 		JBrowse link
G Crh corticotropin releasing hormone IEP protein:increased expression:hypothalamus (rat) RGD PMID:21549066 RGD:5490558 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386 		JBrowse link
G Crp C-reactive protein IEP
ISO 		protein:increased expression:blood: RGD PMID:21797109 PMID:19060982 RGD:6482315, RGD:9491784 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514 		JBrowse link
G Cs citrate synthase IEP protein:decreased expression:cerebral cortex RGD PMID:25299715 RGD:329337347 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938 		JBrowse link
G Csf2 colony stimulating factor 2 ISO protein:increased expression:plasma: RGD PMID:10664226 RGD:10449523 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031 		JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:17505274 PMID:8706460 RGD:11039434 NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO protein:increased expression:lung, macrophage RGD PMID:19733456 RGD:4144897 NCBI chr 8:128,661,294...128,679,048
Ensembl chr 8:128,654,833...128,685,983 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 ISO RGD PMID:9284162 RGD:5135255 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 ISO protein:increased expression:multiple tissues RGD PMID:9284162 RGD:5135255 NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,594,959...17,596,417 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17138957 NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:83,183,808...83,188,602 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP mRNA, protein:decreased expression:liver RGD PMID:15665729 RGD:5147745 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 IEP RGD PMID:18360687 PMID:15665729 RGD:2303376, RGD:5147745 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 IEP RGD PMID:15665729 RGD:5147745 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 IEP RGD PMID:15665729 RGD:5147745 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 IEP RGD PMID:15190971 RGD:1625384 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042 		JBrowse link
G Defb2 defensin beta 2 treatment IMP RGD PMID:17177330 RGD:9685178 NCBI chr16:76,934,341...76,948,284
Ensembl chr16:76,934,337...76,948,299 		JBrowse link
G Edn1 endothelin 1 IEP mRNA, protein:increased expression:multiple (rat) RGD PMID:10838194 RGD:8662298 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Eif2b5 eukaryotic translation initiation factor 2B subunit epsilon IDA protein:increased serine phosphorylation:gastrocnemius RGD PMID:12376332 RGD:11041880 NCBI chr11:93,898,814...93,909,431
Ensembl chr11:93,898,814...93,908,800 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha IEP RGD PMID:8141277 RGD:10395355 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E IDA RGD PMID:17709445 RGD:10401144 NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105 		JBrowse link
G Elane elastase, neutrophil expressed ISO associated with Klebsiella Infections; RGD PMID:9585238 RGD:10450543 NCBI chr 7:10,467,877...10,469,725
Ensembl chr 7:10,467,877...10,469,725 		JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 IEP protein:increased activity:lymphocyte: RGD PMID:22645477 RGD:9685487 NCBI chr 1:249,374,810...249,502,310
Ensembl chr 1:249,374,836...249,502,317 		JBrowse link
G Ep300 E1A binding protein p300 IEP mRNA, protein:increased expression:muscle part of extensor digitorum longus (rat) RGD PMID:20538901 RGD:7364733 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574 		JBrowse link
G Esr2 estrogen receptor 2 IDA RGD PMID:16755255 RGD:5508850 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G F11 coagulation factor XI IEP RGD PMID:12000738 RGD:1598921 NCBI chr16:53,720,502...53,741,547
Ensembl chr16:53,718,621...53,740,941 		JBrowse link
G F2 coagulation factor II, thrombin treatment IDA
ISO 		RGD PMID:19705256 PMID:12361199 RGD:7387324, RGD:10449428 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246 		JBrowse link
G F3 coagulation factor III, tissue factor treatment ISO
IEP 		RGD PMID:9875912 PMID:26311287 RGD:11340217, RGD:11341736 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369 		JBrowse link
G F5 coagulation factor V severity
treatment 		ISO
IMP 		RGD PMID:16235188 PMID:12000738 RGD:4892622, RGD:1598921 NCBI chr13:79,046,657...79,116,247
Ensembl chr13:79,046,448...79,116,247 		JBrowse link
G F7 coagulation factor VII treatment IEP
IDA 		protein:decreased activity:plasma (rat) RGD PMID:3660344 PMID:12000738 RGD:2312320, RGD:1598921 NCBI chr16:83,191,896...83,202,775
Ensembl chr16:83,191,914...83,202,738 		JBrowse link
G F9 coagulation factor IX treatment IEP RGD PMID:12000738 RGD:1598921 NCBI chr  X:143,388,642...143,433,143
Ensembl chr  X:143,388,621...143,433,146 		JBrowse link
G Fas Fas cell surface death receptor IEP mRNA:increased expression:liver RGD PMID:17899301 RGD:2290175 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Faslg Fas ligand IEP mRNA:increased expression:liver RGD PMID:17899301 RGD:2290175 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Fga fibrinogen alpha chain IEP protein:decreased expression:serum (rat) RGD PMID:24667622 RGD:9685020 NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 disease_progression ISO Pneumonia associated sepsis RGD PMID:21219633 RGD:4891938 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750 		JBrowse link
G Foxp3 forkhead box P3 severity ISO RGD PMID:25403265 RGD:38455982 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:17,580,380...17,595,894 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase IEP protein:decreased phosphorylation, decreased activity:T cell (rat) RGD PMID:9551931 RGD:2324866 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:44,322,361...44,515,479 		JBrowse link
G Gas6 growth arrest specific 6 ISO RGD PMID:16374177 RGD:1579935 NCBI chr16:82,747,676...82,778,090
Ensembl chr16:82,747,345...82,778,088 		JBrowse link
G Gata3 GATA binding protein 3 severity ISO RGD PMID:25403265 RGD:38455982 NCBI chr17:73,544,234...73,575,670
Ensembl chr17:73,553,548...73,575,670 		JBrowse link
G Gch1 GTP cyclohydrolase 1 treatment IEP associated with Staphylococcal Infections RGD PMID:12441764 PMID:29428597 RGD:401700401, RGD:401717570 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:22,884,006...22,917,412 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration IEP protein:increased expression:serum: RGD PMID:23073658 RGD:9685733 NCBI chr10:14,223,023...14,225,736
Ensembl chr10:14,223,023...14,225,935 		JBrowse link
G Ghr growth hormone receptor IEP RGD PMID:11126270 RGD:2307382 NCBI chr 2:54,269,066...54,532,595
Ensembl chr 2:54,270,206...54,532,331 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide IEP mRNA,protein:decreased expression:aorta,heart, intestine, plasma: RGD PMID:15155262 RGD:12905047 NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:148,421,315...148,425,969 		JBrowse link
G Ghsr growth hormone secretagogue receptor disease_progression IEP RGD PMID:15155262 RGD:12905047 NCBI chr 2:112,196,158...112,201,666
Ensembl chr 2:112,196,767...112,201,181 		JBrowse link
G Gja5 gap junction protein, alpha 5 IEP mRNA, protein:increased expression:aorta endothelium RGD PMID:15942348 RGD:7207815 NCBI chr 2:187,291,227...187,310,770
Ensembl chr 2:187,234,674...187,318,512 		JBrowse link
G Gp1ba glycoprotein Ib platelet subunit alpha exacerbates ISO associated with thrombocytopenia RGD PMID:24150174 RGD:42722621 NCBI chr10:55,831,901...55,856,729
Ensembl chr10:55,829,832...55,854,560 		JBrowse link
G Gpt glutamic--pyruvic transaminase treatment IEP RGD PMID:26814114 PMID:25243423 RGD:14975161, RGD:401717564 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A IEP protein:increased expression:lung (rat) RGD PMID:19837828 RGD:2325949 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO protein: increased expression: neutrophils RGD PMID:16849637 RGD:5688378 NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:211,009,978...211,031,015 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO protein: increased expression: neutrophils RGD PMID:16849637 RGD:5688378 NCBI chr 1:270,014,314...270,208,294
Ensembl chr 1:270,014,282...270,204,928 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IEP protein:decreased phosphorylation,increased activity: : RGD PMID:20926980 RGD:10045370 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Gsn gelsolin ISO protein:decreased expression:blood serum (human) RGD PMID:9142022 RGD:329333022 NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:38,982,671...39,035,850 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 disease_progression ISO RGD PMID:23131280 RGD:7245480 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Hdac4 histone deacetylase 4 IEP RGD PMID:23925573 RGD:9681446 NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:99,955,116...100,197,637 		JBrowse link
G Hdac6 histone deacetylase 6 IEP RGD PMID:20538901 RGD:7364733 NCBI chr  X:17,222,538...17,244,373
Ensembl chr  X:17,222,856...17,244,370 		JBrowse link
G Hmgb1 high mobility group box 1 treatment IMP
ISO 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19265175 PMID:23146691 PMID:19623040 PMID:20936717 RGD:10402067, RGD:10402173 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase ISO protein: decreased expression RGD PMID:9603077 RGD:5688768 NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 IEP associated with burns;protein:decreased expression:skeletal muscle RGD PMID:16483253 PMID:23143056 RGD:1624233, RGD:10402864 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037 		JBrowse link
G Htra2 HtrA serine peptidase 2 treatment IMP RGD PMID:23557966 RGD:10402934 NCBI chr 4:117,114,631...117,117,793
Ensembl chr 4:117,114,633...117,117,793 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP mRNA:increased expression:brain (rat) RGD PMID:20451670 RGD:4145409 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 treatment ISO RGD PMID:25114116 RGD:39938864 NCBI chr16:74,133,259...74,145,328
Ensembl chr16:74,133,259...74,145,328 		JBrowse link
G Ifng interferon gamma treatment ISO
IEP 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:9806674 PMID:27598601 PMID:28711488 RGD:14975121, RGD:14974250 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il10 interleukin 10 treatment IEP
ISO
IDA 		protein:increased expression:serum
CTD Direct Evidence: therapeutic 		CTD
RGD		 PMID:11441115 PMID:19371254 PMID:27488951 PMID:28108420 PMID:24055021 RGD:2311053, RGD:14975262, RGD:14975261, RGD:7364867 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il12b interleukin 12B IDA protein:increased expression:peritoneal fluid, plasma RGD PMID:15776385 RGD:4888507 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194 		JBrowse link
G Il13 interleukin 13 ISO
IEP 		protein:decreased expression:ileum RGD PMID:10679115 PMID:21159497 RGD:4145654, RGD:8549643 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il16 interleukin 16 ISO associated with Shock, Hemorrhagic;protein:increased expression:lung RGD PMID:19641139 RGD:5024925 NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023 		JBrowse link
G Il17a interleukin 17A IMP RGD PMID:15776385 RGD:4888507 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il17d interleukin 17D severity
treatment 		ISO protein:increased expression:blood serum (human) RGD PMID:31634237 PMID:31634237 PMID:31634237 RGD:40903064, RGD:40903064, RGD:40903064 NCBI chr15:35,786,898...35,804,391
Ensembl chr15:35,786,898...35,804,391 		JBrowse link
G Il1b interleukin 1 beta treatment IEP
ISO 		protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:32062619 PMID:17529909 PMID:21429520 RGD:1626657, RGD:7175319 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 severity ISO RGD PMID:30001716 RGD:39938964 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891 		JBrowse link
G Il1rn interleukin 1 receptor antagonist susceptibility
disease_progression
severity 		ISO
IEP 		mRNA, protein:increased expression:lung
associated with Premature Birth;DNA:polymorphism::
DNA:repeats: :
mRNA:increased expression:pituitary gland (rat)
protein:increased expression:serum (human) 		RGD PMID:20454520 PMID:22882323 PMID:11876758 PMID:10048466 PMID:8196140 More... RGD:4142852, RGD:12910846, RGD:11528543, RGD:7175061, RGD:6909139, RGD:6907358 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il22 interleukin 22 IEP protein:increased expression:plasma RGD PMID:19664145 RGD:5147412 NCBI chr 7:55,687,061...55,691,526
Ensembl chr 7:55,686,896...55,692,201 		JBrowse link
G Il27 interleukin 27 exacerbates
severity
disease_progression 		ISO protein:increased expression:blood (human)
mRNA:increased expression:blood, leukocyte (human)
associated with Herpesviridae Infections;protein:increased expression:blood serum, spleen (mouse)
DNA:SNP:promoter:-964A>G (rs153109) (human) 		RGD PMID:22965735 PMID:18227999 PMID:20493722 PMID:26767500 PMID:30268141 RGD:126790502, RGD:126790544, RGD:126790537, RGD:126790536, RGD:126790509 NCBI chr 1:190,603,684...190,609,292
Ensembl chr 1:190,603,522...190,609,258 		JBrowse link
G Il33 interleukin 33 severity ISO protein:increased expression:plasma,lung
protein:increased expression:plasma, peritoneal fluid:
protein:increased expression:plasma: 		RGD PMID:29672927 PMID:29935165 PMID:29935165 PMID:25665614 RGD:39939028, RGD:40400895, RGD:40400895, RGD:40400739 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901 		JBrowse link
G Il4 interleukin 4 ISO protein:increased expression:plasma RGD PMID:25403265 RGD:38455982 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 treatment IAGP
ISO
IEP
IDA 		associated with Diabetes Mellitus, Non-Insulin-Dependent; mRNA, protein:increased expression:liver, extracellular space (rat)
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:32062619 PMID:19079684 PMID:27598601 PMID:25317848 RGD:2307280, RGD:14975121, RGD:11062009 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 IEP RGD PMID:23073793 RGD:7495805 NCBI chr 7:127,561,777...127,588,762
Ensembl chr 7:127,561,717...127,597,109 		JBrowse link
G Irs1 insulin receptor substrate 1 IDA protein:decreased tyrosine phosphorylation, increased serine phosphorylation:gastrocnemius RGD PMID:19781177 RGD:6482862 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538 		JBrowse link
G Itga4 integrin subunit alpha 4 ISO protein:increased expression:neutrophil RGD PMID:19011162 RGD:13593535 NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039 		JBrowse link
G Itgam integrin subunit alpha M exacerbates IEP protein:increased expression:neutrophil (rat) RGD PMID:9151199 RGD:329902068 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943 		JBrowse link
G Jak2 Janus kinase 2 treatment IDA RGD PMID:24228589 RGD:10411888 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 ISO RGD PMID:21799073 RGD:6892955 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042 		JBrowse link
G Klkb1 kallikrein B1 IMP RGD PMID:22352684 RGD:7297048 NCBI chr16:53,690,180...53,714,570
Ensembl chr16:53,691,220...53,716,339 		JBrowse link
G Klrk1 killer cell lectin like receptor K1 susceptibility ISO associated with Gram-Negative Bacterial Infections RGD PMID:28087665 RGD:38676493 NCBI chr 4:164,767,377...164,778,453
Ensembl chr 4:164,767,946...164,778,382 		JBrowse link
G Lbp lipopolysaccharide binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:22167001 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518 		JBrowse link
G Lcn2 lipocalin 2 exacerbates ISO RGD PMID:22786765 RGD:126781712 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Lep leptin IEP RGD PMID:18575315 RGD:5128818 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Lipc lipase C, hepatic type IDA protein:decreased expression:diaphragm, heart, adipose tissue (rat) RGD PMID:2113037 RGD:2308797 NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285 		JBrowse link
G Lta lymphotoxin alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:22977509 NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,623,527...3,625,533 		JBrowse link
G Ltf lactotransferrin ISO RGD PMID:23425819 RGD:7243861 NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:119,878,344...119,901,189 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15489642 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15489642 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 treatment IDA RGD PMID:14662889 RGD:126928138 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mbl2 mannose binding lectin 2 susceptibility ISO associated with Premature Birth;DNA:polymorphism:exon: RGD PMID:22882323 RGD:12910846 NCBI chr 1:237,429,873...237,465,567
Ensembl chr 1:237,429,973...237,437,546 		JBrowse link
G Mfn2 mitofusin 2 IEP mRNA:decreased expression:liver (rat) RGD PMID:24720571 RGD:13204837 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495 		JBrowse link
G Mif macrophage migration inhibitory factor ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:9892616 PMID:17585860 RGD:4891012 NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121 		JBrowse link
G Mir143 microRNA 143 exacerbates IDA RGD PMID:30546393 RGD:155883166 NCBI chr18:57,371,349...57,371,453 JBrowse link
G Mir146a microRNA 146a ISO miRNA:increased expression:myocardium, blood serum (mouse) RGD PMID:26048146 RGD:126925143 NCBI chr10:28,349,996...28,350,090 JBrowse link
G Mir155 microRNA 155 ISO RGD PMID:27434558 PMID:29979224 RGD:21079467, RGD:21081538 NCBI chr11:37,261,114...37,261,178
Ensembl chr11:37,261,114...37,261,178 		JBrowse link
G Mir223 microRNA 223 ISO RNA:increased expression:plasma: RGD PMID:24680405 RGD:21408586 NCBI chr  X:65,151,383...65,151,492
Ensembl chr  X:65,151,383...65,151,492 		JBrowse link
G Mir494 microRNA 494 ISO RNA:decreased expression:plasma RGD PMID:31002148 RGD:155900762 NCBI chr 6:134,550,115...134,550,197
Ensembl chr 6:134,550,114...134,550,198 		JBrowse link
G Mmp1 matrix metallopeptidase 1 IEP RGD PMID:23478082 RGD:8549749 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964 		JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment IMP RGD PMID:23479197 RGD:8657110 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment IMP
ISO 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16003065 PMID:23479197 RGD:8657110 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase ISO RGD PMID:18424617 RGD:5130966 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b IEP protein:decreased expression:mitochondrion, skeletal muscle RGD PMID:6128308 RGD:2298978 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,124...15,266 		JBrowse link
G Mt1a metallothionein 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17374846 NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr  X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200 		JBrowse link
G Mt2 metallothionein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17374846 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IDA RGD PMID:20577146 RGD:10041013 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Mylk myosin light chain kinase ISO RGD PMID:16399953 RGD:1581052 NCBI chr11:79,288,243...79,535,450
Ensembl chr11:79,288,243...79,535,659 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 IDA RGD PMID:22952679 RGD:13801198 NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:253,357,841...253,362,936 		JBrowse link
G Nefh neurofilament heavy chain severity ISO RGD PMID:30677080 RGD:27226881 NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417 		JBrowse link
G Nefl neurofilament light chain disease_progression ISO RGD PMID:30677080 RGD:27226881 NCBI chr15:46,477,330...46,481,203
Ensembl chr15:46,458,204...46,482,515 		JBrowse link
G Nfkbia NFKB inhibitor alpha treatment IEP RGD PMID:14662889 RGD:126928138 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36627344 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 susceptibility ISO
IEP 		DNA:missense mutations, frameshift mutation:cds:p.R702W, p.G908R, 3020_3021insC (human)
mRNA:increased expression:intestine mucosa (rat) 		RGD PMID:21460759 PMID:24059417 RGD:5508752, RGD:8547531 NCBI chr19:34,555,832...34,596,281
Ensembl chr19:34,555,832...34,722,846 		JBrowse link
G Nos1 nitric oxide synthase 1 IMP RGD PMID:17191663 RGD:1642148 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO
IEP 		associated with lung injury
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:17138957 PMID:20035746 PMID:21184738 PMID:15665729 RGD:4891414, RGD:5147745 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO protein:increased expression:heart
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:20035746 PMID:17999941 RGD:2292119 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Nox1 NADPH oxidase 1 ameliorates ISO RGD PMID:22982050 RGD:329955362 NCBI chr  X:101,572,338...101,625,571
Ensembl chr  X:101,572,340...101,595,520 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 treatment ISO
IDA 		protein:decreased expression:alveolar macrophage RGD PMID:21057058 PMID:21787473 RGD:4892317, RGD:7174711 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Otc ornithine transcarbamylase IEP mRNA:decreased expression:liver (rat) RGD PMID:10353541 RGD:4144069 NCBI chr  X:15,126,358...15,202,473
Ensembl chr  X:15,126,358...15,239,555 		JBrowse link
G Pdcd1 programmed cell death 1 disease_progression ISO protein:increased expression:T cell
protein:increased expression:B cell,CD4T cell 		RGD PMID:30595665 PMID:27156867 PMID:29702526 PMID:29661225 PMID:19332785 RGD:40818235, RGD:41412183, RGD:40822808, RGD:40818424, RGD:40818273 NCBI chr 9:101,866,124...101,879,278
Ensembl chr 9:101,866,126...101,879,270 		JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 ISO protein:increased expression:CD27B cell RGD PMID:29661225 RGD:40818424 NCBI chr 1:236,572,497...236,637,490
Ensembl chr 1:236,565,526...236,637,490 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 disease_progression ISO protein:increased expression:myeloid suppressor cell (mouse) RGD PMID:22451518 RGD:6771205 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839 		JBrowse link
G Pgf placental growth factor ISO protein:increased expression:plasma RGD PMID:16702604 RGD:6483601 NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:110,547,153...110,557,747 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO RGD PMID:20508212 RGD:6482683 NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:54,478,603...54,529,509 		JBrowse link
G Pla2g4a phospholipase A2 group 4A IDA protein:increased activity:liver RGD PMID:9879654 RGD:1642481 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641 		JBrowse link
G Plat plasminogen activator, tissue type treatment IDA RGD PMID:12000738 RGD:1598921 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696 		JBrowse link
G Plau plasminogen activator, urokinase disease_progression ISO Pneumonia associated sepsis RGD PMID:21219633 RGD:4891938 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030 		JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO protein:increased expression:plasma RGD PMID:22550400 RGD:6483789 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha severity ISO DNA:knockout::associated with more severe disease (mouse) RGD PMID:22089192 RGD:5562037 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IEP mRNA:decreased expression:skeletal muscle RGD PMID:20647557 RGD:6484531 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta IEP mRNA:decreased expression:skeletal muscle RGD PMID:20647557 RGD:6484531 NCBI chr18:57,029,264...57,131,466
Ensembl chr18:57,029,275...57,131,466 		JBrowse link
G Ppia peptidylprolyl isomerase A treatment ISO RGD PMID:29680745 RGD:150429626 NCBI chr14:85,491,223...85,496,884
Ensembl chr14:85,492,484...85,497,115 		JBrowse link
G Prkcq protein kinase C, theta IEP protein:decreased expression:lymphocyte RGD PMID:11735277 RGD:1625613 NCBI chr17:72,156,215...72,288,508
Ensembl chr17:72,156,215...72,288,508 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment
disease_progression 		ISO
IEP 		CTD Direct Evidence: therapeutic
mRNA, protein:decreased expression:liver, plasma 		CTD
RGD		 PMID:11820775 PMID:17556722 PMID:22940033 PMID:15241104 RGD:11100029, RGD:11250412 NCBI chr18:24,038,596...24,049,061
Ensembl chr18:24,038,597...24,048,964 		JBrowse link
G Pvt1 Pvt1 oncogene IEP RNA:increased expression:myocardium RGD PMID:30546393 RGD:155883166 NCBI chr 7:95,545,916...95,769,306 JBrowse link
G Rac1 Rac family small GTPase 1 ISO mRNA:increased expression:blood serum (human) RGD PMID:33174038 RGD:152998912 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEP protein:increased expression:nucleus, lung RGD PMID:17626913 RGD:2298853 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Retn resistin ISO protein:increased expression:serum RGD PMID:19545363 RGD:7207151 NCBI chr12:6,508,653...6,511,115
Ensembl chr12:6,508,801...6,511,116 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 no_association
ameliorates 		ISO RGD PMID:23835476 PMID:32152555 PMID:22195746 RGD:127229908, RGD:127229919, RGD:127229909 NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025 		JBrowse link
G Rpl4 ribosomal protein L4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27978524 NCBI chr 8:73,566,477...73,571,600
Ensembl chr 8:73,566,466...73,571,788 		JBrowse link
G Rpl9 ribosomal protein L9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27978524 NCBI chr14:43,247,536...43,250,784
Ensembl chr14:43,247,588...43,250,782
Ensembl chr 1:43,247,588...43,250,782 		JBrowse link
G Rxra retinoid X receptor alpha IDA
IEP 		protein:altered localization:liver
protein:decreased expression:liver 		RGD PMID:19008781 PMID:17483744 RGD:2317466, RGD:1643106 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417 		JBrowse link
G Ryr1 ryanodine receptor 1 IEP mRNA:increased expression:fast muscle tissue
protein:decreased expression:diaphragmaticus muscle 		RGD PMID:18520643 PMID:28044347 RGD:329849107, RGD:329849111 NCBI chr 1:93,420,078...93,551,305
Ensembl chr 1:93,420,078...93,551,305 		JBrowse link
G S100b S100 calcium binding protein B ISO RGD PMID:19809934 RGD:5508796 NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081 		JBrowse link
G Sell selectin L IEP
IMP 		RGD PMID:16026013 PMID:15677732 RGD:5685706, RGD:5686285 NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600 		JBrowse link
G Selp selectin P ISO protein:increased expression:multiple RGD PMID:20690979 RGD:6478679 NCBI chr13:79,009,379...79,044,994
Ensembl chr13:79,009,475...79,044,987 		JBrowse link
G Serpine1 serpin family E member 1 treatment ISO
IDA 		associated with Pneumonia; protein:increased expression:plasma RGD PMID:19753144 PMID:12000738 RGD:4144830, RGD:1598921 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 IEP RGD PMID:20338592 RGD:9999218 NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 IEP mRNA:decreased expression:liver RGD PMID:10500057 RGD:631887 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 IEP protein:increased expression:gastrocnemius
mRNA:increased expression:liver 		RGD PMID:12644450 PMID:11312157 RGD:2298924, RGD:634751 NCBI chr10:5,389,574...5,391,265
Ensembl chr10:5,389,334...5,391,847 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 IEP protein:increased expression:gastrocnemius RGD PMID:12644450 RGD:2298924 NCBI chr 7:31,890,564...31,932,092
Ensembl chr 7:31,874,463...31,930,423 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 IEP protein:increased expression:gastrocnemius
mRNA:increased expression:liver 		RGD PMID:12644450 PMID:11312157 RGD:2298924, RGD:634751 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825 		JBrowse link
G Sod1 superoxide dismutase 1 IEP RGD PMID:26266917 RGD:11035300 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 IEP mRNA, protein:increased expression:lung RGD PMID:26266917 RGD:11035300 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sod3 superoxide dismutase 3 IEP RGD PMID:26266917 RGD:11035300 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 IDA protein:increased activity:liver, lung, small intestine RGD PMID:17067487 RGD:2291905 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 treatment IDA RGD PMID:24228589 RGD:10411888 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO RGD PMID:11257135 RGD:7207876 NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 severity ISO RGD PMID:11257135 RGD:7207876 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795 		JBrowse link
G Tbx21 T-box transcription factor 21 severity ISO RGD PMID:25403265 RGD:38455982 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,578,751...82,595,253 		JBrowse link
G Tfpi tissue factor pathway inhibitor IEP protein:decreased activity:plasma: RGD PMID:15497025 RGD:2313648 NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:89,939,868...89,980,742 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16003065 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgfbi transforming growth factor, beta induced ISO CTD Direct Evidence: marker/mechanism CTD PMID:27887929 NCBI chr17:7,960,885...7,990,234
Ensembl chr17:7,960,516...7,990,471 		JBrowse link
G Thbd thrombomodulin IEP RGD PMID:17577447 RGD:2312462 NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:156,306,632...156,320,582 		JBrowse link
G Tlr2 toll-like receptor 2 IEP associated with Liver Diseases;mRNA:increased expression:liver
associated with Burns;mRNA:increased expression:liver, lung, kidney 		RGD PMID:19489280 PMID:12831613 PMID:14604479 RGD:2312497, RGD:1302750, RGD:2312732 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tlr4 toll-like receptor 4 IEP
ISO 		associated with Liver Diseases;mRNA:increased expression:liver
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:20624996 PMID:19489280 PMID:14604479 RGD:2312497, RGD:2312732 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tlr6 toll-like receptor 6 ISO mRNA:increased expression:plasma RGD PMID:31002148 RGD:155900762 NCBI chr14:43,715,809...43,727,019
Ensembl chr14:43,698,751...43,740,462 		JBrowse link
G Tnf tumor necrosis factor treatment IEP
ISO
IDA 		mRNA:increased expression:heart
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:8741040 PMID:9806674 PMID:15489642 PMID:19695174 PMID:27488951 More... RGD:4144094, RGD:14975262, RGD:7364867, RGD:5147745 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Top2a DNA topoisomerase II alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:27978524 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366 		JBrowse link
G Tpp2 tripeptidyl peptidase 2 IEP mRNA, protein:increased expression, increased activity:extensor digitorum longus (rat) RGD PMID:12147224 RGD:634435 NCBI chr 9:53,538,788...53,620,253
Ensembl chr 9:53,538,313...53,620,251 		JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 disease_progression
treatment 		ISO
IEP 		mRNA:decreased expression:polymorph nuclear cell: RGD PMID:22809118 PMID:22147417 PMID:22996209 RGD:126925981, RGD:127284847, RGD:126925987 NCBI chr 9:20,259,227...20,276,879
Ensembl chr 9:20,261,408...20,276,892 		JBrowse link
G Tslp thymic stromal lymphopoietin treatment
disease_progression 		ISO protein:increased expression:peritoneum, plasma (mouse) RGD PMID:24990542 PMID:26934097 RGD:38549375, RGD:38596335 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,720,257...24,728,420 		JBrowse link
G Xdh xanthine dehydrogenase treatment IDA RGD PMID:19751566 RGD:7247648 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350 		JBrowse link
toxic shock syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin treatment IDA RGD PMID:2424486 RGD:10046036 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:156,569,860...156,619,868 		JBrowse link
G Ace angiotensin I converting enzyme severity ISO DNA:SNP, insertion/deletion:promoter, intron: (rs4291, rs4646994) RGD PMID:28336767 RGD:39939121 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Adk adenosine kinase ISO RGD PMID:8207212 RGD:6482670 NCBI chr15:2,912,543...3,295,745
Ensembl chr15:2,912,544...3,295,745 		JBrowse link
G Adm adrenomedullin IDA
IMP 		RGD PMID:17318497 PMID:17766482 RGD:1625310, RGD:1642599 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371 		JBrowse link
G Adrb2 adrenoceptor beta 2 disease_progression
treatment 		ISO DNA:polymorphism: :rs1042717(human) RGD PMID:19850944 PMID:16076286 RGD:8548487, RGD:8548529 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803 		JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO RGD PMID:21270403 RGD:6767566 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685 		JBrowse link
G Aqp1 aquaporin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24028651 NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504 		JBrowse link
G C5ar1 complement C5a receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18063050 NCBI chr 1:86,077,309...86,088,001 JBrowse link
G Cckbr cholecystokinin B receptor IEP mRNA:increased expression:myocardium RGD PMID:15948246 RGD:2311332 NCBI chr 1:169,183,578...169,193,583
Ensembl chr 1:169,183,194...169,193,745 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 disease_progression ISO RGD PMID:28834779 RGD:14995949 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Cd274 CD274 molecule severity ISO protein:increased expression:serum
protein:increased expression:lymphocyte, mononcyte 		RGD PMID:29702526 PMID:26063974 RGD:40822808, RGD:41410786 NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951 		JBrowse link
G Elane elastase, neutrophil expressed treatment IMP RGD PMID:18323746 RGD:10450579 NCBI chr 7:10,467,877...10,469,725
Ensembl chr 7:10,467,877...10,469,725 		JBrowse link
G Eno2 enolase 2 IEP proteiin:increased expression:serum RGD PMID:17083782 RGD:2293748 NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220 		JBrowse link
G F2 coagulation factor II, thrombin severity ISO protein:decreased expression:blood plasma (human) RGD PMID:2788582 RGD:40822807 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246 		JBrowse link
G Fancc FA complementation group C ISO RGD PMID:17404312 RGD:11045879 NCBI chr17:1,686,374...1,818,672
Ensembl chr17:1,687,017...1,835,096 		JBrowse link
G Gc GC, vitamin D binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:17852808 NCBI chr14:18,916,255...18,951,670
Ensembl chr14:18,916,246...18,951,673 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO mRNA:decreased expression:polymorphonuclear leukocyte RGD PMID:24465168 RGD:126848796 NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:211,009,978...211,031,015 		JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:18208666 RGD:4145362 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B susceptibility ISO associated wit community-acquired pneumonia;DNA:SNP: :1267A>G (human) RGD PMID:12771604 RGD:5147601 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 severity ISO protein:increased activity, increased expression:plasma, heart (human) RGD PMID:21765346 RGD:39939075 NCBI chr16:74,133,259...74,145,328
Ensembl chr16:74,133,259...74,145,328 		JBrowse link
G Ifng interferon gamma ISO protein:increased expression:plasma RGD PMID:25403265 RGD:38455982 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il10 interleukin 10 severity
onset 		ISO protein:increased expression:lung (mouse)
protein:increased expression:plasma 		RGD PMID:12117955 PMID:12117955 PMID:28659355 PMID:25403265 PMID:7593621 RGD:1598471, RGD:1598471, RGD:40890272, RGD:38455982, RGD:11049456 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il19 interleukin 19 ISO RGD PMID:18246602 RGD:5037232 NCBI chr13:44,949,989...44,958,714
Ensembl chr13:44,949,989...44,958,714 		JBrowse link
G Il1b interleukin 1 beta severity ISO protein:increased expression:lung (mouse) RGD PMID:28659355 RGD:40890272 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment
susceptibility 		ISO human gene in a mouse model
associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma;DNA:polymorphism:: 		RGD PMID:15516267 PMID:23014359 RGD:8551736, RGD:11522756 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il20ra interleukin 20 receptor subunit alpha ISO mRNA:increased expression:multiple RGD PMID:18246602 RGD:5037232 NCBI chr 1:16,243,683...16,313,229
Ensembl chr 1:16,243,801...16,313,221 		JBrowse link
G Il20rb interleukin 20 receptor subunit beta ISO mRNA:increased expression:multiple RGD PMID:18246602 RGD:5037232 NCBI chr 8:109,858,108...109,896,066
Ensembl chr 8:109,854,012...109,889,363 		JBrowse link
G Il27 interleukin 27 ISO protein, mRNA:increased expression:blood serum, spleen (mouse) RGD PMID:20435892 RGD:126790535 NCBI chr 1:190,603,684...190,609,292
Ensembl chr 1:190,603,522...190,609,258 		JBrowse link
G Il6 interleukin 6 treatment ISO RGD PMID:2124237 RGD:11060276 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mbl2 mannose binding lectin 2 susceptibility ISO associated with acute pyelonephritis;DNA:SNPs, missense mutations, haplotypes:promoter, cds:multiple RGD PMID:17202308 PMID:17202308 RGD:6903268, RGD:6903268 NCBI chr 1:237,429,873...237,465,567
Ensembl chr 1:237,429,973...237,437,546 		JBrowse link
G Mc2r melanocortin 2 receptor IEP protein:increased expression:liver (rat) RGD PMID:2822467 RGD:6484558 NCBI chr18:64,279,878...64,291,775
Ensembl chr18:64,277,360...64,291,881 		JBrowse link
G Mif macrophage migration inhibitory factor IMP
IDA 		RGD PMID:17381395 PMID:17565848 RGD:4891013, RGD:1641978 NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121 		JBrowse link
G Mir155 microRNA 155 ISO RGD PMID:29979224 RGD:21081538 NCBI chr11:37,261,114...37,261,178
Ensembl chr11:37,261,114...37,261,178 		JBrowse link
G Mir21 microRNA 21 exacerbates
ameliorates 		ISO RGD PMID:28437377 PMID:31189875 RGD:41404641, RGD:41404698 NCBI chr10:71,902,600...71,902,691 JBrowse link
G Mir494 microRNA 494 severity ISO RGD PMID:30783439 RGD:150527846 NCBI chr 6:134,550,115...134,550,197
Ensembl chr 6:134,550,114...134,550,198 		JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 susceptibility ISO associated with Burns; DNA:missense mutation:cds:m.4216T>C (human) RGD PMID:19487983 RGD:5148017 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,729...3,685 		JBrowse link
G Nfkbia NFKB inhibitor alpha treatment IEP RGD PMID:11961112 RGD:126928137 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos2 nitric oxide synthase 2 IDA
ISO 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:8745224 PMID:16601845 RGD:1580268 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nppc natriuretic peptide C ISO protein:increased expression:plasma RGD PMID:8117275 RGD:1642297 NCBI chr 9:94,767,986...94,772,186
Ensembl chr 9:94,767,986...94,772,186 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase ISO RGD PMID:15677345 RGD:8657146 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 ISO RGD PMID:12445868 RGD:10414070 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pdcd1 programmed cell death 1 severity ISO protein:increased expression:serum
protein:increased expression:lymphocyte, mononcyte 		RGD PMID:29702526 PMID:26063974 RGD:40822808, RGD:41410786 NCBI chr 9:101,866,124...101,879,278
Ensembl chr 9:101,866,126...101,879,270 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta severity ISO RGD PMID:28659355 RGD:40890272 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO RGD PMID:20693875 RGD:6484122 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:19320827 PMID:21850534 RGD:11100015, RGD:11100041 NCBI chr18:24,038,596...24,049,061
Ensembl chr18:24,038,597...24,048,964 		JBrowse link
G Ptx3 pentraxin 3 ISO protein:increased expression:plasma (human) RGD PMID:30687307 RGD:38508896 NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:152,781,955...152,803,372 		JBrowse link
G Ren renin exacerbates ISO protein:increased activity:blood plasma (human) RGD PMID:31723628 RGD:125097502 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G RT1-Da RT1 class II, locus Da disease_progression ISO associated with Burns
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:28771573 PMID:17568330 PMID:15644645 RGD:5490160, RGD:5490203 NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,513,908...4,520,383 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 ISO mRNA:decreased expression:blood RGD PMID:15644645 RGD:5490203 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,550,596...4,560,165 		JBrowse link
G Sell selectin L IEP protein:increased expression:plasma RGD PMID:19375498 RGD:5685700 NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600 		JBrowse link
G Serpinc1 serpin family C member 1 treatment ISO RGD PMID:16732381 RGD:1599323 NCBI chr13:75,790,558...75,804,826
Ensembl chr13:75,790,546...75,817,643 		JBrowse link
G Serpine1 serpin family E member 1 susceptibility ISO associated with Pneumonia; DNA:polymorphism:promoter:rs1799768 (human) RGD PMID:20429897 RGD:4144828 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Serpinf1 serpin family F member 1 severity ISO protein:decreased expression:plasma (human) RGD PMID:6158114 RGD:36174004 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,748,506...60,760,898 		JBrowse link
G Serping1 serpin family G member 1 treatment ISO RGD PMID:8172580 RGD:8661646 NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:90,249,423...90,258,717 		JBrowse link
G Sftpb surfactant protein B ISO associated with Pneumonia;DNA:polymorphism: :1580C>T (human) RGD PMID:15190959 RGD:4143404 NCBI chr 4:105,917,495...105,926,631
Ensembl chr 4:105,917,578...105,927,646 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 severity ISO RGD PMID:19469017 RGD:150573701 NCBI chr10:5,389,574...5,391,265
Ensembl chr10:5,389,334...5,391,847 		JBrowse link
G Tbxa2r thromboxane A2 receptor treatment IMP RGD PMID:7816742 RGD:11059599 NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:9,034,108...9,038,905 		JBrowse link
G Tfpi tissue factor pathway inhibitor treatment ISO RGD PMID:11776329 RGD:11062085 NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:89,939,868...89,980,742 		JBrowse link
G Thpo thrombopoietin ISO protein:increased expression:serum: RGD PMID:20467749 RGD:10449021 Ensembl chr11:93,686,834...93,693,320 JBrowse link
G Tnf tumor necrosis factor treatment IEP
ISO 		protein:increased expression:peritoneal macrophage, cell surface (rat)
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:20054000 PMID:2213560 PMID:12622907 RGD:10449465, RGD:1598936 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 ISO mRNA:decreased expression:polymorphonuclear leukocyte RGD PMID:24465168 RGD:126848796 NCBI chr 9:20,259,227...20,276,879
Ensembl chr 9:20,261,408...20,276,892 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A ISO RGD PMID:23422584 RGD:39938961 NCBI chr 5:142,661,193...142,670,051
Ensembl chr 5:142,661,199...142,669,985 		JBrowse link
Viremia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bst2 bone marrow stromal cell antigen 2 ISO associated with Retroviridae Infections; RGD PMID:28381565 RGD:14398820 NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,251,847...18,254,967 		JBrowse link
G Il2rb interleukin 2 receptor subunit beta ISO RGD PMID:29307521 RGD:42724467 NCBI chr 7:111,913,828...111,928,537
Ensembl chr 7:111,913,828...111,928,537 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    syndrome 11431
      Systemic Inflammatory Response Syndrome 399
        Cytokine Release Syndrome 0
        Fetal Inflammatory Response Syndrome 1
        Sepsis + 397
Path 2
Term Annotations click to browse term
  disease 19167
    Pathological Conditions, Signs and Symptoms 13667
      Pathologic Processes 8430
        Shock 420
          Systemic Inflammatory Response Syndrome 399
            Cytokine Release Syndrome 0
            Fetal Inflammatory Response Syndrome 1
            Sepsis + 397
paths to the root