RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Radiation Injuries
Accession: DOID:9000111
browse the term
Definition: Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.
Synonyms: exact_synonym: Radiation Injury; Radiation Sickness; Radiation Sicknesses; Radiation Syndrome; Radiation Syndromes; Radiation-induced nausea and vomiting
primary_id: MESH:D011832
xref: EFO:0006912 ; EFO:0009566
GViewer not supported for the selected species.
G
Bdnf
brain derived neurotrophic factor
treatment
ISO
RGD
PMID:24333433
RGD:10059359
NCBI chrNW_004936540:5,530,081...5,582,765
Ensembl chrNW_004936540:5,529,942...5,585,014
G
Csf2
colony stimulating factor 2
ISO
mRNA:increased expression:bone marrow,spleen:
RGD
PMID:7662961
RGD:10449513
NCBI chrNW_004936647:3,081,896...3,083,864
Ensembl chrNW_004936647:3,081,896...3,083,864
G
Gpx3
glutathione peroxidase 3
treatment
ISO
RGD
PMID:20105084
RGD:401827914
NCBI chrNW_004936647:3,904,787...3,914,223
Ensembl chrNW_004936647:3,906,113...3,913,498
G
Hif1a
hypoxia inducible factor 1 subunit alpha
treatment
ISO
RGD
PMID:17340073
RGD:8695920
NCBI chrNW_004936495:5,770,988...5,816,157
Ensembl chrNW_004936495:5,770,669...5,816,157
G
Il1a
interleukin 1 alpha
ISO
RGD
PMID:7938676
RGD:7794763
NCBI chrNW_004936783:1,210,715...1,218,315
Ensembl chrNW_004936783:1,210,809...1,218,315
G
Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16540396 PMID:21945096
NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781
G
Tgfbr2
transforming growth factor beta receptor 2
ISO
RGD
PMID:12957270
RGD:1601599
NCBI chrNW_004936473:21,324,669...21,409,430
Ensembl chrNW_004936473:21,324,658...21,409,430
G
Abcb1
ATP binding cassette subfamily B member 1
susceptibility
ISO
DNA:missense mutation:cds:p.G671V (human)
RGD
PMID:16330681
RGD:11041175
NCBI chrNW_004936763:1,225,355...1,308,257
Ensembl chrNW_004936763:1,226,482...1,297,427
G
Acvr2b
activin A receptor type 2B
treatment
ISO
human construct in mouse model
RGD
PMID:30765322
RGD:329849112
NCBI chrNW_004936473:27,816,366...27,822,555
Ensembl chrNW_004936473:27,815,399...27,822,476
G
Capn2
calpain 2
treatment
ISO
RGD
PMID:25634181
RGD:13792617
NCBI chrNW_004936526:879,765...932,682
Ensembl chrNW_004936526:879,765...932,682
G
Ercc2
ERCC excision repair 2, TFIIH core complex helicase subunit
ISO
associated with Leukemia, Myeloid, Acute;DNA:SNP:exon:p.K751Q (rs13181) (human)
RGD
PMID:24284041
RGD:11252190
NCBI chrNW_004936706:1,816,561...1,829,638
Ensembl chrNW_004936706:1,816,571...1,829,692
G
Acacb
acetyl-CoA carboxylase beta
ISO
mRNA, protein:increased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chrNW_004936769:950,970...1,053,671
Ensembl chrNW_004936769:950,845...1,051,887
G
Agt
angiotensinogen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33676887
NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261
G
Bche
butyrylcholinesterase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:26145887
NCBI chrNW_004936707:1,784,338...1,913,401
Ensembl chrNW_004936707:1,854,444...1,913,460
G
Bmp2
bone morphogenetic protein 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29800642
NCBI chrNW_004936485:12,428,765...12,439,570
Ensembl chrNW_004936485:12,428,710...12,439,454
G
Cat
catalase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:35792220
NCBI chrNW_004936533:3,601,270...3,637,128
Ensembl chrNW_004936533:3,600,955...3,637,422
G
Cpt1a
carnitine palmitoyltransferase 1A
ISO
mRNA, protein:decreased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chrNW_004936599:1,491,934...1,535,101
Ensembl chrNW_004936599:1,482,172...1,535,119
G
Csf1
colony stimulating factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32068018
NCBI chrNW_004936704:1,372,137...1,393,355
Ensembl chrNW_004936704:1,378,103...1,393,542
G
Fas
Fas cell surface death receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34713381
NCBI chrNW_004936735:209,369...234,582
G
Faslg
Fas ligand
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34713381
NCBI chrNW_004936481:14,789,547...14,795,780
G
Fto
FTO alpha-ketoglutarate dependent dioxygenase
ISO
DNA:hypermethylation:promoter
RGD
PMID:35462195
RGD:329951017
NCBI chrNW_004936475:6,321,725...6,689,410
Ensembl chrNW_004936475:6,321,711...6,689,588
G
Hbegf
heparin binding EGF like growth factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29305325
NCBI chrNW_004936531:9,332,939...9,345,039
Ensembl chrNW_004936531:9,332,898...9,345,067
G
Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32068018
NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165
G
Kcnn2
potassium calcium-activated channel subfamily N member 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:32909839 PMID:33887967
NCBI chrNW_004937043:133,981...269,593
G
LOC101964975
interleukin-8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chrNW_004936598:1,779,471...1,781,353
Ensembl chrNW_004936598:1,779,471...1,781,353
G
Mettl14
methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34648132
NCBI chrNW_004936869:568,324...589,972
Ensembl chrNW_004936869:568,840...590,269
G
Mlycd
malonyl-CoA decarboxylase
ISO
protein:increased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chrNW_004936641:3,836,418...3,846,485
G
Nos3
nitric oxide synthase 3
treatment
ISO
associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma;DNA:polymorphism: :894G>T(human)
RGD
PMID:26345518
RGD:11533645
NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534
G
Nppb
natriuretic peptide B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chrNW_004936474:683,325...684,662
Ensembl chrNW_004936474:683,325...684,665
G
Nrg1
neuregulin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29305325
NCBI chrNW_004936766:1,104,841...1,306,368
Ensembl chrNW_004936766:1,104,728...1,305,972
G
Prkaa2
protein kinase AMP-activated catalytic subunit alpha 2
ISO
protein:decreased expression:serum, heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chrNW_004936522:4,872,360...4,939,873
Ensembl chrNW_004936522:4,875,046...4,939,879
G
Rac1
Rac family small GTPase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28710503
NCBI chrNW_004936750:107,689...122,679
Ensembl chrNW_004936750:107,689...122,676
G
Rarg
retinoic acid receptor gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26237429
NCBI chrNW_004936512:10,502,954...10,524,796
Ensembl chrNW_004936512:10,500,622...10,524,824
G
Rnf10
ring finger protein 10
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:36740146
NCBI chrNW_004936668:389,961...427,213
Ensembl chrNW_004936668:389,343...427,258
G
Sirt6
sirtuin 6
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:34713381
NCBI chrNW_004936588:2,387,162...2,394,066
Ensembl chrNW_004936588:2,386,977...2,394,096
G
Tlr2
toll like receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chrNW_004936576:522,234...531,660
Ensembl chrNW_004936576:527,434...529,788
G
Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987 PMID:32068018
NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
G
Tp53
tumor protein p53
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30009776 PMID:34713381
NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425
G
Agtr1
angiotensin II receptor type 1
ISO
RGD
PMID:14982483
RGD:6903857
NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985
G
Agtr2
angiotensin II receptor type 2
ISO
RGD
PMID:14982483
RGD:6903857
NCBI chrNW_004936479:13,252,678...13,255,570
Ensembl chrNW_004936479:13,252,678...13,255,570
G
Aif1
allograft inflammatory factor 1
ISO
protein:decreased expression:brain (rat)
RGD
PMID:19070908
RGD:2313024
NCBI chrNW_004936727:1,907,493...1,909,350
Ensembl chrNW_004936727:1,907,505...1,909,338
G
Casp3
caspase 3
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chrNW_004936554:4,571,072...4,593,765
G
Casp8
caspase 8
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chrNW_004936726:554,627...596,334
Ensembl chrNW_004936726:554,758...595,922
G
Casp9
caspase 9
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chrNW_004936474:3,178,097...3,196,130
G
Ccn2
cellular communication network factor 2
ISO
protein:increased expression:kidney (rat)
RGD
PMID:19080126
RGD:2314603
NCBI chrNW_004936560:42,561...45,748
Ensembl chrNW_004936560:42,537...45,807
G
Eng
endoglin
ISO
protein:decreased expression:lung (rat) kidney
RGD
PMID:22151990 PMID:23022174
RGD:7248771 RGD:7257525
NCBI chrNW_004936487:15,467,165...15,499,180
Ensembl chrNW_004936487:15,467,835...15,477,488
G
Fas
Fas cell surface death receptor
ISO
mRNA:increased expression:testis (rat)
RGD
PMID:9927315
RGD:8662886
NCBI chrNW_004936735:209,369...234,582
G
Hif1a
hypoxia inducible factor 1 subunit alpha
ISO
protein:increased expression:white matter of spinal cord (rat) CTD Direct Evidence: therapeutic
RGD CTD
PMID:15161688 PMID:23065176
RGD:9068912
NCBI chrNW_004936495:5,770,988...5,816,157
Ensembl chrNW_004936495:5,770,669...5,816,157
G
Hmox1
heme oxygenase 1
treatment
ISO
RGD
PMID:22247972
RGD:10755582
NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311
G
Ifng
interferon gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452
G
Igf2
insulin like growth factor 2
ISO
mRNA:increased expression:brain
RGD
PMID:11213353
RGD:5509971
NCBI chrNW_004936816:972,902...981,232
Ensembl chrNW_004936816:972,282...979,167
G
Il10
interleukin 10
treatment
ISO
protein:increased expression:plasma
RGD
PMID:23788042 PMID:23968122
RGD:11049496 RGD:7365012
NCBI chrNW_004936557:5,834,874...5,838,502
Ensembl chrNW_004936557:5,834,874...5,838,502
G
Il18
interleukin 18
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189
G
Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165
G
Lcn2
lipocalin 2
ISO
mRNA,protein:increased expression:liver, heart, kidney,spleen, serum,
RGD
PMID:23331620
RGD:126790570
NCBI chrNW_004936487:15,721,752...15,725,396
Ensembl chrNW_004936487:15,721,684...15,728,221
G
Mapk1
mitogen-activated protein kinase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chrNW_004936619:1,889,841...1,932,646
Ensembl chrNW_004936619:1,889,708...1,932,646
G
Mapk3
mitogen-activated protein kinase 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chrNW_004936501:12,342,670...12,390,650
Ensembl chrNW_004936501:12,384,804...12,392,180
G
Nos1
nitric oxide synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20726721
NCBI chrNW_004936558:5,162,471...5,302,488
Ensembl chrNW_004936558:5,233,459...5,301,414
G
Pcna
proliferating cell nuclear antigen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21931560
NCBI chrNW_004936485:13,766,221...13,771,215
G
Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
mRNA:altered expression:jejunum, duodenum, ileum (rat)
RGD
PMID:22227376
RGD:6767294
NCBI chrNW_004936541:4,873,459...4,919,787
Ensembl chrNW_004936541:4,873,182...4,937,500
G
Ptgs1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:intestine
RGD
PMID:17699727
RGD:2290567
NCBI chrNW_004936487:10,745,465...10,758,812
Ensembl chrNW_004936487:10,745,327...10,758,823
G
Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
protein:increased expression:intestine
RGD
PMID:17699727
RGD:2290567
NCBI chrNW_004936481:3,821,564...3,828,086
G
Sod1
superoxide dismutase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chrNW_004936500:10,345,154...10,352,873
Ensembl chrNW_004936500:10,345,154...10,352,867
G
Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11121210 PMID:20726721
NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781
G
Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
G
LOC101968921
angiotensin-converting enzyme
treatment
ISO
RGD
PMID:8995730
RGD:12880012
NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177
G
Serpine1
serpin family E member 1
treatment
ISO
RGD
PMID:8995730
RGD:12880012
NCBI chrNW_004936543:1,032,543...1,040,956
Ensembl chrNW_004936543:1,032,794...1,039,123
G
Alox5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:1886988
RGD:4890434
NCBI chrNW_004936554:7,807,914...7,848,691
Ensembl chrNW_004936554:7,808,355...7,867,931
G
Atm
ATM serine/threonine kinase
susceptibility
ISO
associated with lung cancer;DNA:SNPs:promoter:���111G>A,126713G>A (rs189037, s373759) (human)
RGD
PMID:20171797
RGD:150340755
NCBI chrNW_004936551:359,134...534,672
Ensembl chrNW_004936551:359,362...532,211
G
C3
complement C3
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chrNW_004936588:3,985,732...4,023,221
G
Cblb
Cbl proto-oncogene B
susceptibility
ISO
associated with lung non-small cell carcinoma; DNA:SNP,haplotype: :rs2305035(human)
RGD
PMID:26732495
RGD:150540334
NCBI chrNW_004936701:1,157,790...1,353,375
Ensembl chrNW_004936701:1,157,797...1,353,388
G
Ccl17
C-C motif chemokine ligand 17
ISO
mRNA, protein:increased expression:lung, alveolar macrophage
RGD
PMID:15293604
RGD:4145517
NCBI chrNW_004936475:9,475,013...9,476,326
Ensembl chrNW_004936475:9,474,961...9,476,398
G
Ccl22
C-C motif chemokine ligand 22
ISO
mRNA, protein:increased expression:lung, alveolar macrophage
RGD
PMID:15293604
RGD:4145517
NCBI chrNW_004936475:9,432,505...9,436,240
Ensembl chrNW_004936475:9,432,505...9,436,240
G
Il13
interleukin 13
susceptibility
ISO
associated with carcinoma, non-small-cell lung; DNA:SNPs: :rs20541, rs180925 (human)
RGD
PMID:20811626
RGD:5131286
NCBI chrNW_004936647:2,529,933...2,532,503
Ensembl chrNW_004936647:2,530,491...2,532,373
G
Il1a
interleukin 1 alpha
susceptibility
ISO
associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1800587,rs17561(human)
RGD
PMID:20811626
RGD:5131286
NCBI chrNW_004936783:1,210,715...1,218,315
Ensembl chrNW_004936783:1,210,809...1,218,315
G
Mif
macrophage migration inhibitory factor
susceptibility
ISO
associated with carcinoma, non-small-cell lung; DNA:SNP: :rs755622(human)
RGD
PMID:20811626
RGD:5131286
NCBI chrNW_004936619:1,207,058...1,208,010
Ensembl chrNW_004936619:1,203,746...1,208,442
G
Nos3
nitric oxide synthase 3
susceptibility
ISO
associated with carcinoma, non-small-cell lung;DNA:SNP:cds:c.894G>T rs1799983 (human)
RGD
PMID:20811626
RGD:5131286
NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534
G
Sftpd
surfactant protein D
susceptibility
ISO
RGD
PMID:20459699
RGD:4143486
NCBI chrNW_004936716:60,754...73,010
Ensembl chrNW_004936716:60,656...73,099
G
Tgfb1
transforming growth factor beta 1
susceptibility
ISO
DNA:SNP:exon:869T>C (rs1982073) (human) protein:increased expression:blood
RGD
PMID:18411002 PMID:19380441 PMID:19943923
RGD:4145121 RGD:4145136 RGD:4145278
NCBI chrNW_004936661:3,742,080...3,758,266
Ensembl chrNW_004936661:3,742,066...3,758,272
G
Tnf
tumor necrosis factor
susceptibility
ISO
associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1799724(human)
RGD
PMID:20811626
RGD:5131286
NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
G
Tnfrsf1a
TNF receptor superfamily member 1A
ISO
RGD
PMID:18347190
RGD:5131153
NCBI chrNW_004936709:1,407,327...1,421,448
Ensembl chrNW_004936709:1,407,278...1,421,921
G
Vtn
vitronectin
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chrNW_004936538:4,522,275...4,525,245
Ensembl chrNW_004936538:4,522,074...4,525,336
G
Cd274
CD274 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28736328
NCBI chrNW_004936539:132,870...145,288
Ensembl chrNW_004936539:132,868...143,602
G
Cebpa
CCAAT enhancer binding protein alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21346772
NCBI chrNW_004936570:2,513,561...2,516,213
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all