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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Radiation Injuries
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Accession:DOID:9000111 term browser browse the term
Definition:Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.
Synonyms:exact_synonym: Radiation Injury;   Radiation Sickness;   Radiation Sicknesses;   Radiation Syndrome;   Radiation Syndromes;   Radiation-induced nausea and vomiting
 primary_id: MESH:D011832
 xref: EFO:0006912;   EFO:0009566


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Radiation Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain derived neurotrophic factor treatment ISO RGD PMID:24333433 RGD:10059359 NCBI chrNW_004936540:5,530,081...5,582,765
Ensembl chrNW_004936540:5,529,942...5,585,014
JBrowse link
G Csf2 colony stimulating factor 2 ISO mRNA:increased expression:bone marrow,spleen: RGD PMID:7662961 RGD:10449513 NCBI chrNW_004936647:3,081,896...3,083,864
Ensembl chrNW_004936647:3,081,896...3,083,864
JBrowse link
G Gpx3 glutathione peroxidase 3 treatment ISO RGD PMID:20105084 RGD:401827914 NCBI chrNW_004936647:3,904,787...3,914,223
Ensembl chrNW_004936647:3,906,113...3,913,498
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha treatment ISO RGD PMID:17340073 RGD:8695920 NCBI chrNW_004936495:5,770,988...5,816,157
Ensembl chrNW_004936495:5,770,669...5,816,157
JBrowse link
G Il1a interleukin 1 alpha ISO RGD PMID:7938676 RGD:7794763 NCBI chrNW_004936783:1,210,715...1,218,315
Ensembl chrNW_004936783:1,210,809...1,218,315
JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:16540396 PMID:21945096 NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781
JBrowse link
G Tgfbr2 transforming growth factor beta receptor 2 ISO RGD PMID:12957270 RGD:1601599 NCBI chrNW_004936473:21,324,669...21,409,430
Ensembl chrNW_004936473:21,324,658...21,409,430
JBrowse link
Anthracycline-induced Cardiotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1 ATP binding cassette subfamily B member 1 susceptibility ISO DNA:missense mutation:cds:p.G671V (human) RGD PMID:16330681 RGD:11041175 NCBI chrNW_004936763:1,225,355...1,308,257
Ensembl chrNW_004936763:1,226,482...1,297,427
JBrowse link
G Acvr2b activin A receptor type 2B treatment ISO human construct in mouse model RGD PMID:30765322 RGD:329849112 NCBI chrNW_004936473:27,816,366...27,822,555
Ensembl chrNW_004936473:27,815,399...27,822,476
JBrowse link
G Capn2 calpain 2 treatment ISO RGD PMID:25634181 RGD:13792617 NCBI chrNW_004936526:879,765...932,682
Ensembl chrNW_004936526:879,765...932,682
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit ISO associated with Leukemia, Myeloid, Acute;DNA:SNP:exon:p.K751Q (rs13181) (human) RGD PMID:24284041 RGD:11252190 NCBI chrNW_004936706:1,816,561...1,829,638
Ensembl chrNW_004936706:1,816,571...1,829,692
JBrowse link
Cardiotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acacb acetyl-CoA carboxylase beta ISO mRNA, protein:increased expression:heart (rat) RGD PMID:30644033 RGD:329955369 NCBI chrNW_004936769:950,970...1,053,671
Ensembl chrNW_004936769:950,845...1,051,887
JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:33676887 NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261
JBrowse link
G Bche butyrylcholinesterase ISO CTD Direct Evidence: therapeutic CTD PMID:26145887 NCBI chrNW_004936707:1,784,338...1,913,401
Ensembl chrNW_004936707:1,854,444...1,913,460
JBrowse link
G Bmp2 bone morphogenetic protein 2 ISO CTD Direct Evidence: therapeutic CTD PMID:29800642 NCBI chrNW_004936485:12,428,765...12,439,570
Ensembl chrNW_004936485:12,428,710...12,439,454
JBrowse link
G Cat catalase ISO CTD Direct Evidence: therapeutic CTD PMID:35792220 NCBI chrNW_004936533:3,601,270...3,637,128
Ensembl chrNW_004936533:3,600,955...3,637,422
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A ISO mRNA, protein:decreased expression:heart (rat) RGD PMID:30644033 RGD:329955369 NCBI chrNW_004936599:1,491,934...1,535,101
Ensembl chrNW_004936599:1,482,172...1,535,119
JBrowse link
G Csf1 colony stimulating factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32068018 NCBI chrNW_004936704:1,372,137...1,393,355
Ensembl chrNW_004936704:1,378,103...1,393,542
JBrowse link
G Fas Fas cell surface death receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:34713381 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Faslg Fas ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:34713381 NCBI chrNW_004936481:14,789,547...14,795,780 JBrowse link
G Fto FTO alpha-ketoglutarate dependent dioxygenase ISO DNA:hypermethylation:promoter RGD PMID:35462195 RGD:329951017 NCBI chrNW_004936475:6,321,725...6,689,410
Ensembl chrNW_004936475:6,321,711...6,689,588
JBrowse link
G Hbegf heparin binding EGF like growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:29305325 NCBI chrNW_004936531:9,332,939...9,345,039
Ensembl chrNW_004936531:9,332,898...9,345,067
JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:32068018 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 ISO CTD Direct Evidence: therapeutic CTD PMID:32909839 PMID:33887967 NCBI chrNW_004937043:133,981...269,593 JBrowse link
G LOC101964975 interleukin-8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 NCBI chrNW_004936598:1,779,471...1,781,353
Ensembl chrNW_004936598:1,779,471...1,781,353
JBrowse link
G Mettl14 methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:34648132 NCBI chrNW_004936869:568,324...589,972
Ensembl chrNW_004936869:568,840...590,269
JBrowse link
G Mlycd malonyl-CoA decarboxylase ISO protein:increased expression:heart (rat) RGD PMID:30644033 RGD:329955369 NCBI chrNW_004936641:3,836,418...3,846,485 JBrowse link
G Nos3 nitric oxide synthase 3 treatment ISO associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma;DNA:polymorphism: :894G>T(human) RGD PMID:26345518 RGD:11533645 NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534
JBrowse link
G Nppb natriuretic peptide B ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 NCBI chrNW_004936474:683,325...684,662
Ensembl chrNW_004936474:683,325...684,665
JBrowse link
G Nrg1 neuregulin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:29305325 NCBI chrNW_004936766:1,104,841...1,306,368
Ensembl chrNW_004936766:1,104,728...1,305,972
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 ISO protein:decreased expression:serum, heart (rat) RGD PMID:30644033 RGD:329955369 NCBI chrNW_004936522:4,872,360...4,939,873
Ensembl chrNW_004936522:4,875,046...4,939,879
JBrowse link
G Rac1 Rac family small GTPase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28710503 NCBI chrNW_004936750:107,689...122,679
Ensembl chrNW_004936750:107,689...122,676
JBrowse link
G Rarg retinoic acid receptor gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:26237429 NCBI chrNW_004936512:10,502,954...10,524,796
Ensembl chrNW_004936512:10,500,622...10,524,824
JBrowse link
G Rnf10 ring finger protein 10 ISO CTD Direct Evidence: therapeutic CTD PMID:36740146 NCBI chrNW_004936668:389,961...427,213
Ensembl chrNW_004936668:389,343...427,258
JBrowse link
G Sirt6 sirtuin 6 ISO CTD Direct Evidence: therapeutic CTD PMID:34713381 NCBI chrNW_004936588:2,387,162...2,394,066
Ensembl chrNW_004936588:2,386,977...2,394,096
JBrowse link
G Tlr2 toll like receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 NCBI chrNW_004936576:522,234...531,660
Ensembl chrNW_004936576:527,434...529,788
JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 PMID:32068018 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
JBrowse link
G Tp53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30009776 PMID:34713381 NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425
JBrowse link
Experimental Radiation Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1 angiotensin II receptor type 1 ISO RGD PMID:14982483 RGD:6903857 NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985
JBrowse link
G Agtr2 angiotensin II receptor type 2 ISO RGD PMID:14982483 RGD:6903857 NCBI chrNW_004936479:13,252,678...13,255,570
Ensembl chrNW_004936479:13,252,678...13,255,570
JBrowse link
G Aif1 allograft inflammatory factor 1 ISO protein:decreased expression:brain (rat) RGD PMID:19070908 RGD:2313024 NCBI chrNW_004936727:1,907,493...1,909,350
Ensembl chrNW_004936727:1,907,505...1,909,338
JBrowse link
G Casp3 caspase 3 treatment ISO RGD PMID:24939579 RGD:13782350 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Casp8 caspase 8 treatment ISO RGD PMID:24939579 RGD:13782350 NCBI chrNW_004936726:554,627...596,334
Ensembl chrNW_004936726:554,758...595,922
JBrowse link
G Casp9 caspase 9 treatment ISO RGD PMID:24939579 RGD:13782350 NCBI chrNW_004936474:3,178,097...3,196,130 JBrowse link
G Ccn2 cellular communication network factor 2 ISO protein:increased expression:kidney (rat) RGD PMID:19080126 RGD:2314603 NCBI chrNW_004936560:42,561...45,748
Ensembl chrNW_004936560:42,537...45,807
JBrowse link
G Eng endoglin ISO protein:decreased expression:lung (rat)
kidney
RGD PMID:22151990 PMID:23022174 RGD:7248771 RGD:7257525 NCBI chrNW_004936487:15,467,165...15,499,180
Ensembl chrNW_004936487:15,467,835...15,477,488
JBrowse link
G Fas Fas cell surface death receptor ISO mRNA:increased expression:testis (rat) RGD PMID:9927315 RGD:8662886 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:white matter of spinal cord (rat)
CTD Direct Evidence: therapeutic
RGD
CTD
PMID:15161688 PMID:23065176 RGD:9068912 NCBI chrNW_004936495:5,770,988...5,816,157
Ensembl chrNW_004936495:5,770,669...5,816,157
JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO RGD PMID:22247972 RGD:10755582 NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311
JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:11121210 NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452
JBrowse link
G Igf2 insulin like growth factor 2 ISO mRNA:increased expression:brain RGD PMID:11213353 RGD:5509971 NCBI chrNW_004936816:972,902...981,232
Ensembl chrNW_004936816:972,282...979,167
JBrowse link
G Il10 interleukin 10 treatment ISO protein:increased expression:plasma RGD PMID:23788042 PMID:23968122 RGD:11049496 RGD:7365012 NCBI chrNW_004936557:5,834,874...5,838,502
Ensembl chrNW_004936557:5,834,874...5,838,502
JBrowse link
G Il18 interleukin 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11121210 NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189
JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:11121210 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165
JBrowse link
G Lcn2 lipocalin 2 ISO mRNA,protein:increased expression:liver, heart, kidney,spleen, serum, RGD PMID:23331620 RGD:126790570 NCBI chrNW_004936487:15,721,752...15,725,396
Ensembl chrNW_004936487:15,721,684...15,728,221
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:22247605 NCBI chrNW_004936619:1,889,841...1,932,646
Ensembl chrNW_004936619:1,889,708...1,932,646
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO CTD Direct Evidence: therapeutic CTD PMID:22247605 NCBI chrNW_004936501:12,342,670...12,390,650
Ensembl chrNW_004936501:12,384,804...12,392,180
JBrowse link
G Nos1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20726721 NCBI chrNW_004936558:5,162,471...5,302,488
Ensembl chrNW_004936558:5,233,459...5,301,414
JBrowse link
G Pcna proliferating cell nuclear antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:21931560 NCBI chrNW_004936485:13,766,221...13,771,215 JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO mRNA:altered expression:jejunum, duodenum, ileum (rat) RGD PMID:22227376 RGD:6767294 NCBI chrNW_004936541:4,873,459...4,919,787
Ensembl chrNW_004936541:4,873,182...4,937,500
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression:intestine RGD PMID:17699727 RGD:2290567 NCBI chrNW_004936487:10,745,465...10,758,812
Ensembl chrNW_004936487:10,745,327...10,758,823
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO protein:increased expression:intestine RGD PMID:17699727 RGD:2290567 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Sod1 superoxide dismutase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:22247605 NCBI chrNW_004936500:10,345,154...10,352,873
Ensembl chrNW_004936500:10,345,154...10,352,867
JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:11121210 PMID:20726721 NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781
JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:11121210 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
JBrowse link
Radiation Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101968921 angiotensin-converting enzyme treatment ISO RGD PMID:8995730 RGD:12880012 NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177
JBrowse link
G Serpine1 serpin family E member 1 treatment ISO RGD PMID:8995730 RGD:12880012 NCBI chrNW_004936543:1,032,543...1,040,956
Ensembl chrNW_004936543:1,032,794...1,039,123
JBrowse link
Radiation Pneumonitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase ISO RGD PMID:1886988 RGD:4890434 NCBI chrNW_004936554:7,807,914...7,848,691
Ensembl chrNW_004936554:7,808,355...7,867,931
JBrowse link
G Atm ATM serine/threonine kinase susceptibility ISO associated with lung cancer;DNA:SNPs:promoter:���111G>A,126713G>A (rs189037, s373759) (human) RGD PMID:20171797 RGD:150340755 NCBI chrNW_004936551:359,134...534,672
Ensembl chrNW_004936551:359,362...532,211
JBrowse link
G C3 complement C3 ISO Protein: increased expression: plasma RGD PMID:20510197 RGD:5129484 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Cblb Cbl proto-oncogene B susceptibility ISO associated with lung non-small cell carcinoma; DNA:SNP,haplotype: :rs2305035(human) RGD PMID:26732495 RGD:150540334 NCBI chrNW_004936701:1,157,790...1,353,375
Ensembl chrNW_004936701:1,157,797...1,353,388
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 ISO mRNA, protein:increased expression:lung, alveolar macrophage RGD PMID:15293604 RGD:4145517 NCBI chrNW_004936475:9,475,013...9,476,326
Ensembl chrNW_004936475:9,474,961...9,476,398
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 ISO mRNA, protein:increased expression:lung, alveolar macrophage RGD PMID:15293604 RGD:4145517 NCBI chrNW_004936475:9,432,505...9,436,240
Ensembl chrNW_004936475:9,432,505...9,436,240
JBrowse link
G Il13 interleukin 13 susceptibility ISO associated with carcinoma, non-small-cell lung; DNA:SNPs: :rs20541, rs180925 (human) RGD PMID:20811626 RGD:5131286 NCBI chrNW_004936647:2,529,933...2,532,503
Ensembl chrNW_004936647:2,530,491...2,532,373
JBrowse link
G Il1a interleukin 1 alpha susceptibility ISO associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1800587,rs17561(human) RGD PMID:20811626 RGD:5131286 NCBI chrNW_004936783:1,210,715...1,218,315
Ensembl chrNW_004936783:1,210,809...1,218,315
JBrowse link
G Mif macrophage migration inhibitory factor susceptibility ISO associated with carcinoma, non-small-cell lung; DNA:SNP: :rs755622(human) RGD PMID:20811626 RGD:5131286 NCBI chrNW_004936619:1,207,058...1,208,010
Ensembl chrNW_004936619:1,203,746...1,208,442
JBrowse link
G Nos3 nitric oxide synthase 3 susceptibility ISO associated with carcinoma, non-small-cell lung;DNA:SNP:cds:c.894G>T rs1799983 (human) RGD PMID:20811626 RGD:5131286 NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534
JBrowse link
G Sftpd surfactant protein D susceptibility ISO RGD PMID:20459699 RGD:4143486 NCBI chrNW_004936716:60,754...73,010
Ensembl chrNW_004936716:60,656...73,099
JBrowse link
G Tgfb1 transforming growth factor beta 1 susceptibility ISO DNA:SNP:exon:869T>C (rs1982073) (human)
protein:increased expression:blood
RGD PMID:18411002 PMID:19380441 PMID:19943923 RGD:4145121 RGD:4145136 RGD:4145278 NCBI chrNW_004936661:3,742,080...3,758,266
Ensembl chrNW_004936661:3,742,066...3,758,272
JBrowse link
G Tnf tumor necrosis factor susceptibility ISO associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1799724(human) RGD PMID:20811626 RGD:5131286 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO RGD PMID:18347190 RGD:5131153 NCBI chrNW_004936709:1,407,327...1,421,448
Ensembl chrNW_004936709:1,407,278...1,421,921
JBrowse link
G Vtn vitronectin ISO Protein: increased expression: plasma RGD PMID:20510197 RGD:5129484 NCBI chrNW_004936538:4,522,275...4,525,245
Ensembl chrNW_004936538:4,522,074...4,525,336
JBrowse link
Radiation-Induced Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:28736328 NCBI chrNW_004936539:132,870...145,288
Ensembl chrNW_004936539:132,868...143,602
JBrowse link
G Cebpa CCAAT enhancer binding protein alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:21346772 NCBI chrNW_004936570:2,513,561...2,516,213 JBrowse link

Term paths to the root
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Term Annotations click to browse term
  disease 14637
    Wounds and Injuries 904
      Radiation Injuries 76
        Acute Radiation Syndrome 0
        Cardiotoxicity + 31
        Experimental Radiation Injuries 27
        Leukemia, Radiation-Induced 0
        Myotoxicity 0
        Osteoradionecrosis 0
        Radiation Induced Brachial Plexopathy 0
        Radiation Nephropathy 2
        Radiation Pneumonitis 15
        Radiation-Induced Abnormalities 0
        Radiation-Induced Neoplasms + 2
        Radiodermatitis 0
        radiation-induced brain injury 0
paths to the root