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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Radiation Injuries
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Accession:DOID:9000111 term browser browse the term
Definition:Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.
Synonyms:exact_synonym: Radiation Injury;   Radiation Sickness;   Radiation Sicknesses;   Radiation Syndrome;   Radiation Syndromes;   Radiation-induced nausea and vomiting
 primary_id: MESH:D011832
 xref: EFO:0006912;   EFO:0009566



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Radiation Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDNF brain derived neurotrophic factor treatment ISO RGD PMID:24333433 RGD:10059359 NCBI chr 2:32,623,668...32,679,293
Ensembl chr 2:32,624,048...32,679,765
JBrowse link
G CSF2 colony stimulating factor 2 ISO mRNA:increased expression:bone marrow,spleen: RGD PMID:7662961 RGD:10449513 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155
JBrowse link
G GPX3 glutathione peroxidase 3 treatment ISO RGD PMID:20105084 RGD:401827914 NCBI chr16:71,980,467...71,989,011
Ensembl chr16:71,980,475...71,989,026
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha treatment ISO RGD PMID:17340073 RGD:8695920 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845
JBrowse link
G IL1A interleukin 1 alpha ISO RGD PMID:7938676 RGD:7794763 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,121
JBrowse link
G MIR122 microRNA mir-122 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32422326 NCBI chr 1:162,329,776...162,329,860
Ensembl chr 1:162,329,767...162,329,860
JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:16540396 PMID:21945096 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 ISO RGD PMID:12957270 RGD:1601599 NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,490...16,878,160
JBrowse link
Anthracycline-induced Cardiotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 susceptibility ISO DNA:missense mutation:cds:p.G671V (human) RGD PMID:16330681 RGD:11041175 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G ACVR2B activin A receptor type 2B treatment ISO human construct in mouse model RGD PMID:30765322 RGD:329849112 NCBI chr13:23,237,699...23,276,086
Ensembl chr13:23,237,699...23,267,373
JBrowse link
G CAPN2 calpain 2 treatment ISO RGD PMID:25634181 RGD:13792617 NCBI chr10:19,758,824...19,820,241
Ensembl chr10:19,758,757...19,820,246
JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit ISO associated with Leukemia, Myeloid, Acute;DNA:SNP:exon:p.K751Q (rs13181) (human) RGD PMID:24284041 RGD:11252190 NCBI chr 6:51,734,318...51,757,508
Ensembl chr 6:51,734,320...51,757,553
JBrowse link
Cardiotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACACB acetyl-CoA carboxylase beta ISO mRNA, protein:increased expression:heart (rat) RGD PMID:30644033 RGD:329955369 NCBI chr14:41,621,574...41,739,916
Ensembl chr14:41,621,574...41,739,916
JBrowse link
G AGT angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:33676887 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833
JBrowse link
G BCHE butyrylcholinesterase ISO CTD Direct Evidence: therapeutic CTD PMID:26145887 NCBI chr13:104,946,732...105,007,568 JBrowse link
G BMP2 bone morphogenetic protein 2 ISO CTD Direct Evidence: therapeutic CTD PMID:29800642 NCBI chr17:15,750,487...15,762,982
Ensembl chr17:15,749,835...15,761,195
JBrowse link
G CAT catalase ISO CTD Direct Evidence: therapeutic CTD PMID:35792220 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A ISO mRNA, protein:decreased expression:heart (rat) RGD PMID:30644033 RGD:329955369 NCBI chr 2:4,250,642...4,293,914
Ensembl chr 2:4,233,099...4,293,911
JBrowse link
G CSF1 colony stimulating factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32068018 NCBI chr 4:110,178,466...110,198,232
Ensembl chr 4:110,178,475...110,197,900
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G FAS Fas cell surface death receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:34713381 NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716
JBrowse link
G FASLG Fas ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:34713381 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464
JBrowse link
G FTO FTO alpha-ketoglutarate dependent dioxygenase ISO DNA:hypermethylation:promoter RGD PMID:35462195 RGD:329951017 NCBI chr 6:31,177,112...31,564,674
Ensembl chr 6:31,174,569...31,564,718
JBrowse link
G HBEGF heparin binding EGF like growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:29305325 NCBI chr 2:142,102,455...142,115,192
Ensembl chr 2:142,102,458...142,115,174
JBrowse link
G KCNN2 potassium calcium-activated channel subfamily N member 2 ISO CTD Direct Evidence: therapeutic CTD PMID:32909839 PMID:33887967 NCBI chr 2:118,439,328...118,882,299
Ensembl chr 2:118,439,403...118,882,295
JBrowse link
G LOC110258578 interleukin-1 beta-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:32068018
G METTL14 methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:34648132 NCBI chr 8:105,019,539...105,053,603
Ensembl chr 8:105,015,420...105,053,563
JBrowse link
G MIR143 microRNA mir-143 ameliorates ISO RGD PMID:32170053 RGD:155883163 NCBI chr 2:150,578,738...150,578,817
Ensembl chr 2:150,578,738...150,578,817
JBrowse link
G MLYCD malonyl-CoA decarboxylase ISO protein:increased expression:heart (rat) RGD PMID:30644033 RGD:329955369 NCBI chr 6:4,683,386...4,698,698
Ensembl chr 6:4,681,664...4,698,661
JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma;DNA:polymorphism: :894G>T(human) RGD PMID:26345518 RGD:11533645 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
G NPPB natriuretic peptide B ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 NCBI chr 6:71,930,374...71,931,843
Ensembl chr 6:71,930,382...71,932,254
JBrowse link
G NRG1 neuregulin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:29305325 NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,630,679...52,839,505
JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 ISO protein:decreased expression:serum, heart (rat) RGD PMID:30644033 RGD:329955369 NCBI chr 6:155,683,392...155,754,283
Ensembl chr 6:155,681,784...155,754,278
JBrowse link
G RAC1 Rac family small GTPase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28710503 NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543
JBrowse link
G RARG retinoic acid receptor gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:26237429 NCBI chr 5:18,436,267...18,458,625
Ensembl chr 5:18,436,270...18,458,624
JBrowse link
G RNF10 ring finger protein 10 ISO CTD Direct Evidence: therapeutic CTD PMID:36740146 NCBI chr14:40,481,239...40,521,998
Ensembl chr14:40,481,249...40,519,886
JBrowse link
G SIRT6 sirtuin 6 ISO CTD Direct Evidence: therapeutic CTD PMID:34713381 NCBI chr 2:74,568,539...74,577,774
Ensembl chr 2:74,568,493...74,577,772
JBrowse link
G TLR2 toll like receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330
JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 PMID:32068018 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415
JBrowse link
G TP53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30009776 PMID:34713381 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
JBrowse link
Experimental Radiation Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:14982483 RGD:6903857 NCBI chr13:88,934,873...88,980,317
Ensembl chr13:88,934,868...88,983,105
JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:14982483 RGD:6903857 NCBI chr  X:95,267,709...95,272,237
Ensembl chr  X:95,269,300...95,270,388
JBrowse link
G AIF1 allograft inflammatory factor 1 ISO protein:decreased expression:brain (rat) RGD PMID:19070908 RGD:2313024 NCBI chr 7:23,711,752...23,731,191
Ensembl chr 7:23,728,726...23,731,675
JBrowse link
G CASP3 caspase 3 treatment ISO RGD PMID:24939579 RGD:13782350 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G CASP8 caspase 8 treatment ISO RGD PMID:24939579 RGD:13782350 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
JBrowse link
G CASP9 caspase 9 treatment ISO RGD PMID:24939579 RGD:13782350 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
JBrowse link
G CCN2 cellular communication network factor 2 ISO protein:increased expression:kidney (rat) RGD PMID:19080126 RGD:2314603 NCBI chr 1:31,674,398...31,677,697
Ensembl chr 1:31,674,394...31,677,691
JBrowse link
G ENG endoglin ISO protein:decreased expression:lung (rat)
kidney
RGD PMID:22151990 PMID:23022174 RGD:7248771 RGD:7257525 NCBI chr 1:268,309,379...268,343,861
Ensembl chr 1:268,309,400...268,343,783
JBrowse link
G FAS Fas cell surface death receptor ISO mRNA:increased expression:testis (rat) RGD PMID:9927315 RGD:8662886 NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO CTD Direct Evidence: therapeutic
protein:increased expression:white matter of spinal cord (rat)
CTD
RGD
PMID:15161688 PMID:23065176 RGD:9068912 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845
JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO RGD PMID:22247972 RGD:10755582
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:11121210 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670
JBrowse link
G IGF2 insulin like growth factor 2 ISO mRNA:increased expression:brain RGD PMID:11213353 RGD:5509971 NCBI chr 2:1,469,183...1,496,417 JBrowse link
G IL10 interleukin 10 treatment ISO protein:increased expression:plasma RGD PMID:23788042 PMID:23968122 RGD:11049496 RGD:7365012 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378
JBrowse link
G IL18 interleukin 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11121210 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219
JBrowse link
G LCN2 lipocalin 2 ISO mRNA,protein:increased expression:liver, heart, kidney,spleen, serum, RGD PMID:23331620 RGD:126790570 NCBI chr 1:268,609,975...268,614,651
Ensembl chr 1:268,609,887...268,614,644
JBrowse link
G LOC110258578 interleukin-1 beta-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:11121210
G MAPK1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:22247605 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 ISO CTD Direct Evidence: therapeutic CTD PMID:22247605 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MIR122 microRNA mir-122 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32422326 NCBI chr 1:162,329,776...162,329,860
Ensembl chr 1:162,329,767...162,329,860
JBrowse link
G NOS1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20726721 NCBI chr14:35,112,898...35,299,297
Ensembl chr14:35,113,184...35,295,944
JBrowse link
G PCNA proliferating cell nuclear antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:21931560 NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744
JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO mRNA:altered expression:jejunum, duodenum, ileum (rat) RGD PMID:22227376 RGD:6767294 NCBI chr12:14,667,643...14,723,296
Ensembl chr12:14,649,044...14,723,293
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression:intestine RGD PMID:17699727 RGD:2290567 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO protein:increased expression:intestine RGD PMID:17699727 RGD:2290567 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
JBrowse link
G SOD1 superoxide dismutase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:22247605 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:11121210 PMID:20726721 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:11121210 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415
JBrowse link
Radiation Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme treatment ISO RGD PMID:8995730 RGD:12880012 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703
JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO RGD PMID:8995730 RGD:12880012 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547
JBrowse link
Radiation Pneumonitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase ISO RGD PMID:1886988 RGD:4890434 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,019...90,907,090
JBrowse link
G ATM ATM serine/threonine kinase susceptibility ISO associated with lung cancer;DNA:SNPs:promoter:���111G>A,126713G>A (rs189037, s373759) (human) RGD PMID:20171797 RGD:150340755 NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,657...36,759,552
JBrowse link
G C3 complement C3 ISO Protein: increased expression: plasma RGD PMID:20510197 RGD:5129484 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228
JBrowse link
G C4BPA complement component 4 binding protein alpha ISO Protein: increased expression: plasma RGD PMID:20510197 RGD:5129484 NCBI chr 9:67,726,159...67,774,369
Ensembl chr 9:67,731,179...67,776,115
JBrowse link
G CBLB Cbl proto-oncogene B susceptibility ISO associated with lung non-small cell carcinoma; DNA:SNP,haplotype: :rs2305035(human) RGD PMID:26732495 RGD:150540334 NCBI chr13:153,480,525...153,700,115
Ensembl chr13:153,395,978...153,700,056
JBrowse link
G CCL17 C-C motif chemokine ligand 17 ISO mRNA, protein:increased expression:lung, alveolar macrophage RGD PMID:15293604 RGD:4145517 NCBI chr 6:19,345,929...19,372,972
Ensembl chr 6:19,345,941...19,348,926
JBrowse link
G CCL22 C-C motif chemokine ligand 22 ISO mRNA, protein:increased expression:lung, alveolar macrophage RGD PMID:15293604 RGD:4145517 NCBI chr 6:19,296,726...19,301,506
Ensembl chr 6:19,296,637...19,302,737
JBrowse link
G IL13 interleukin 13 susceptibility ISO associated with carcinoma, non-small-cell lung; DNA:SNPs: :rs20541, rs180925 (human) RGD PMID:20811626 RGD:5131286 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093
JBrowse link
G IL1A interleukin 1 alpha susceptibility ISO associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1800587,rs17561(human) RGD PMID:20811626 RGD:5131286 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,121
JBrowse link
G MIF macrophage migration inhibitory factor susceptibility ISO associated with carcinoma, non-small-cell lung; DNA:SNP: :rs755622(human) RGD PMID:20811626 RGD:5131286 NCBI chr14:49,840,303...49,841,063
Ensembl chr14:49,840,305...49,841,068
JBrowse link
G NOS3 nitric oxide synthase 3 susceptibility ISO associated with carcinoma, non-small-cell lung;DNA:SNP:cds:c.894G>T rs1799983 (human) RGD PMID:20811626 RGD:5131286 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
G SFTPD surfactant protein D susceptibility ISO RGD PMID:20459699 RGD:4143486 NCBI chr14:82,051,400...82,069,258
Ensembl chr14:82,051,451...82,067,976
JBrowse link
G TGFB1 transforming growth factor beta 1 susceptibility ISO protein:increased expression:blood
DNA:SNP:exon:869T>C (rs1982073) (human)
RGD PMID:18411002 PMID:19380441 PMID:19943923 RGD:4145121 RGD:4145136 RGD:4145278 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046
JBrowse link
G TNF tumor necrosis factor susceptibility ISO associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1799724(human) RGD PMID:20811626 RGD:5131286 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO RGD PMID:18347190 RGD:5131153 NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,051...64,331,909
JBrowse link
G VTN vitronectin ISO Protein: increased expression: plasma RGD PMID:20510197 RGD:5129484 NCBI chr12:44,650,532...44,653,916
Ensembl chr12:44,650,534...44,655,355
JBrowse link
Radiation-Induced Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD274 CD274 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:28736328 NCBI chr 1:216,646,378...216,792,731
Ensembl chr 1:216,660,041...216,792,724
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:21346772 NCBI chr 6:43,083,200...43,085,884
Ensembl chr 6:43,083,207...43,085,836
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  disease 15426
    Wounds and Injuries 948
      Radiation Injuries 80
        Acute Radiation Syndrome 0
        Cardiotoxicity + 33
        Experimental Radiation Injuries 28
        Leukemia, Radiation-Induced 0
        Myotoxicity 0
        Osteoradionecrosis 0
        Radiation Induced Brachial Plexopathy 0
        Radiation Nephropathy 2
        Radiation Pneumonitis 16
        Radiation-Induced Abnormalities 0
        Radiation-Induced Neoplasms + 2
        Radiodermatitis 0
        radiation-induced brain injury 0
paths to the root