RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Radiation Injuries
Accession: DOID:9000111
browse the term
Definition: Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.
Synonyms: exact_synonym: Radiation Injury; Radiation Sickness; Radiation Sicknesses; Radiation Syndrome; Radiation Syndromes; Radiation-induced nausea and vomiting
primary_id: MESH:D011832
xref: EFO:0006912 ; EFO:0009566
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BDNF
brain derived neurotrophic factor
treatment
ISO
RGD
PMID:24333433
RGD:10059359
NCBI chr 2:32,623,668...32,679,293
Ensembl chr 2:32,624,048...32,679,765
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CSF2
colony stimulating factor 2
ISO
mRNA:increased expression:bone marrow,spleen:
RGD
PMID:7662961
RGD:10449513
NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155
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GPX3
glutathione peroxidase 3
treatment
ISO
RGD
PMID:20105084
RGD:401827914
NCBI chr16:71,980,467...71,989,011
Ensembl chr16:71,980,475...71,989,026
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HIF1A
hypoxia inducible factor 1 subunit alpha
treatment
ISO
RGD
PMID:17340073
RGD:8695920
NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845
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IL1A
interleukin 1 alpha
ISO
RGD
PMID:7938676
RGD:7794763
NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,121
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MIR122
microRNA mir-122
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32422326
NCBI chr 1:162,329,776...162,329,860
Ensembl chr 1:162,329,767...162,329,860
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SOD2
superoxide dismutase 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16540396 PMID:21945096
NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
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TGFBR2
transforming growth factor beta receptor 2
ISO
RGD
PMID:12957270
RGD:1601599
NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,490...16,878,160
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ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
susceptibility
ISO
DNA:missense mutation:cds:p.G671V (human)
RGD
PMID:16330681
RGD:11041175
NCBI chr 9:93,049,955...93,146,469
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ACVR2B
activin A receptor type 2B
treatment
ISO
human construct in mouse model
RGD
PMID:30765322
RGD:329849112
NCBI chr13:23,237,699...23,276,086
Ensembl chr13:23,237,699...23,267,373
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CAPN2
calpain 2
treatment
ISO
RGD
PMID:25634181
RGD:13792617
NCBI chr10:19,758,824...19,820,241
Ensembl chr10:19,758,757...19,820,246
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ERCC2
ERCC excision repair 2, TFIIH core complex helicase subunit
ISO
associated with Leukemia, Myeloid, Acute;DNA:SNP:exon:p.K751Q (rs13181) (human)
RGD
PMID:24284041
RGD:11252190
NCBI chr 6:51,734,318...51,757,508
Ensembl chr 6:51,734,320...51,757,553
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ACACB
acetyl-CoA carboxylase beta
ISO
mRNA, protein:increased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr14:41,621,574...41,739,916
Ensembl chr14:41,621,574...41,739,916
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AGT
angiotensinogen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33676887
NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833
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BCHE
butyrylcholinesterase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:26145887
NCBI chr13:104,946,732...105,007,568
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BMP2
bone morphogenetic protein 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29800642
NCBI chr17:15,750,487...15,762,982
Ensembl chr17:15,749,835...15,761,195
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CAT
catalase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:35792220
NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
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CCL2
chemokine (C-C motif) ligand 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
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CPT1A
carnitine palmitoyltransferase 1A
ISO
mRNA, protein:decreased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr 2:4,250,642...4,293,914
Ensembl chr 2:4,233,099...4,293,911
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CSF1
colony stimulating factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32068018
NCBI chr 4:110,178,466...110,198,232
Ensembl chr 4:110,178,475...110,197,900
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CXCL8
C-X-C motif chemokine ligand 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
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FAS
Fas cell surface death receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34713381
NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716
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FASLG
Fas ligand
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34713381
NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464
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FTO
FTO alpha-ketoglutarate dependent dioxygenase
ISO
DNA:hypermethylation:promoter
RGD
PMID:35462195
RGD:329951017
NCBI chr 6:31,177,112...31,564,674
Ensembl chr 6:31,174,569...31,564,718
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HBEGF
heparin binding EGF like growth factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29305325
NCBI chr 2:142,102,455...142,115,192
Ensembl chr 2:142,102,458...142,115,174
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KCNN2
potassium calcium-activated channel subfamily N member 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:32909839 PMID:33887967
NCBI chr 2:118,439,328...118,882,299
Ensembl chr 2:118,439,403...118,882,295
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LOC110258578
interleukin-1 beta-like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32068018
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METTL14
methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34648132
NCBI chr 8:105,019,539...105,053,603
Ensembl chr 8:105,015,420...105,053,563
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MIR143
microRNA mir-143
ameliorates
ISO
RGD
PMID:32170053
RGD:155883163
NCBI chr 2:150,578,738...150,578,817
Ensembl chr 2:150,578,738...150,578,817
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MLYCD
malonyl-CoA decarboxylase
ISO
protein:increased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr 6:4,683,386...4,698,698
Ensembl chr 6:4,681,664...4,698,661
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NOS3
nitric oxide synthase 3
treatment
ISO
associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma;DNA:polymorphism: :894G>T(human)
RGD
PMID:26345518
RGD:11533645
NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
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NPPB
natriuretic peptide B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr 6:71,930,374...71,931,843
Ensembl chr 6:71,930,382...71,932,254
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NRG1
neuregulin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29305325
NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,630,679...52,839,505
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PRKAA2
protein kinase AMP-activated catalytic subunit alpha 2
ISO
protein:decreased expression:serum, heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr 6:155,683,392...155,754,283
Ensembl chr 6:155,681,784...155,754,278
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RAC1
Rac family small GTPase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28710503
NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543
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RARG
retinoic acid receptor gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26237429
NCBI chr 5:18,436,267...18,458,625
Ensembl chr 5:18,436,270...18,458,624
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RNF10
ring finger protein 10
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:36740146
NCBI chr14:40,481,239...40,521,998
Ensembl chr14:40,481,249...40,519,886
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SIRT6
sirtuin 6
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:34713381
NCBI chr 2:74,568,539...74,577,774
Ensembl chr 2:74,568,493...74,577,772
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TLR2
toll like receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330
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TNF
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987 PMID:32068018
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415
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TP53
tumor protein p53
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30009776 PMID:34713381
NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
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AGTR1
angiotensin II receptor type 1
ISO
RGD
PMID:14982483
RGD:6903857
NCBI chr13:88,934,873...88,980,317
Ensembl chr13:88,934,868...88,983,105
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AGTR2
angiotensin II receptor type 2
ISO
RGD
PMID:14982483
RGD:6903857
NCBI chr X:95,267,709...95,272,237
Ensembl chr X:95,269,300...95,270,388
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AIF1
allograft inflammatory factor 1
ISO
protein:decreased expression:brain (rat)
RGD
PMID:19070908
RGD:2313024
NCBI chr 7:23,711,752...23,731,191
Ensembl chr 7:23,728,726...23,731,675
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CASP3
caspase 3
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
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CASP8
caspase 8
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
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CASP9
caspase 9
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
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CCN2
cellular communication network factor 2
ISO
protein:increased expression:kidney (rat)
RGD
PMID:19080126
RGD:2314603
NCBI chr 1:31,674,398...31,677,697
Ensembl chr 1:31,674,394...31,677,691
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ENG
endoglin
ISO
protein:decreased expression:lung (rat) kidney
RGD
PMID:22151990 PMID:23022174
RGD:7248771 RGD:7257525
NCBI chr 1:268,309,379...268,343,861
Ensembl chr 1:268,309,400...268,343,783
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FAS
Fas cell surface death receptor
ISO
mRNA:increased expression:testis (rat)
RGD
PMID:9927315
RGD:8662886
NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716
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HIF1A
hypoxia inducible factor 1 subunit alpha
ISO
CTD Direct Evidence: therapeutic protein:increased expression:white matter of spinal cord (rat)
CTD RGD
PMID:15161688 PMID:23065176
RGD:9068912
NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845
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HMOX1
heme oxygenase 1
treatment
ISO
RGD
PMID:22247972
RGD:10755582
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IFNG
interferon gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670
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IGF2
insulin like growth factor 2
ISO
mRNA:increased expression:brain
RGD
PMID:11213353
RGD:5509971
NCBI chr 2:1,469,183...1,496,417
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IL10
interleukin 10
treatment
ISO
protein:increased expression:plasma
RGD
PMID:23788042 PMID:23968122
RGD:11049496 RGD:7365012
NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378
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IL18
interleukin 18
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219
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LCN2
lipocalin 2
ISO
mRNA,protein:increased expression:liver, heart, kidney,spleen, serum,
RGD
PMID:23331620
RGD:126790570
NCBI chr 1:268,609,975...268,614,651
Ensembl chr 1:268,609,887...268,614,644
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LOC110258578
interleukin-1 beta-like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
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MAPK1
mitogen-activated protein kinase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
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MAPK3
mitogen-activated protein kinase 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
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MIR122
microRNA mir-122
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32422326
NCBI chr 1:162,329,776...162,329,860
Ensembl chr 1:162,329,767...162,329,860
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NOS1
nitric oxide synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20726721
NCBI chr14:35,112,898...35,299,297
Ensembl chr14:35,113,184...35,295,944
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PCNA
proliferating cell nuclear antigen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21931560
NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744
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PECAM1
platelet and endothelial cell adhesion molecule 1
ISO
mRNA:altered expression:jejunum, duodenum, ileum (rat)
RGD
PMID:22227376
RGD:6767294
NCBI chr12:14,667,643...14,723,296
Ensembl chr12:14,649,044...14,723,293
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PTGS1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:intestine
RGD
PMID:17699727
RGD:2290567
NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035
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PTGS2
prostaglandin-endoperoxide synthase 2
ISO
protein:increased expression:intestine
RGD
PMID:17699727
RGD:2290567
NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
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SOD1
superoxide dismutase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
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SOD2
superoxide dismutase 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11121210 PMID:20726721
NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
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TNF
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415
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ACE
angiotensin I converting enzyme
treatment
ISO
RGD
PMID:8995730
RGD:12880012
NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703
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SERPINE1
serpin family E member 1
treatment
ISO
RGD
PMID:8995730
RGD:12880012
NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547
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ALOX5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:1886988
RGD:4890434
NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,019...90,907,090
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ATM
ATM serine/threonine kinase
susceptibility
ISO
associated with lung cancer;DNA:SNPs:promoter:���111G>A,126713G>A (rs189037, s373759) (human)
RGD
PMID:20171797
RGD:150340755
NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,657...36,759,552
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C3
complement C3
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228
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C4BPA
complement component 4 binding protein alpha
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr 9:67,726,159...67,774,369
Ensembl chr 9:67,731,179...67,776,115
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CBLB
Cbl proto-oncogene B
susceptibility
ISO
associated with lung non-small cell carcinoma; DNA:SNP,haplotype: :rs2305035(human)
RGD
PMID:26732495
RGD:150540334
NCBI chr13:153,480,525...153,700,115
Ensembl chr13:153,395,978...153,700,056
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CCL17
C-C motif chemokine ligand 17
ISO
mRNA, protein:increased expression:lung, alveolar macrophage
RGD
PMID:15293604
RGD:4145517
NCBI chr 6:19,345,929...19,372,972
Ensembl chr 6:19,345,941...19,348,926
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CCL22
C-C motif chemokine ligand 22
ISO
mRNA, protein:increased expression:lung, alveolar macrophage
RGD
PMID:15293604
RGD:4145517
NCBI chr 6:19,296,726...19,301,506
Ensembl chr 6:19,296,637...19,302,737
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IL13
interleukin 13
susceptibility
ISO
associated with carcinoma, non-small-cell lung; DNA:SNPs: :rs20541, rs180925 (human)
RGD
PMID:20811626
RGD:5131286
NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093
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IL1A
interleukin 1 alpha
susceptibility
ISO
associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1800587,rs17561(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,121
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MIF
macrophage migration inhibitory factor
susceptibility
ISO
associated with carcinoma, non-small-cell lung; DNA:SNP: :rs755622(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr14:49,840,303...49,841,063
Ensembl chr14:49,840,305...49,841,068
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NOS3
nitric oxide synthase 3
susceptibility
ISO
associated with carcinoma, non-small-cell lung;DNA:SNP:cds:c.894G>T rs1799983 (human)
RGD
PMID:20811626
RGD:5131286
NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
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SFTPD
surfactant protein D
susceptibility
ISO
RGD
PMID:20459699
RGD:4143486
NCBI chr14:82,051,400...82,069,258
Ensembl chr14:82,051,451...82,067,976
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TGFB1
transforming growth factor beta 1
susceptibility
ISO
protein:increased expression:blood DNA:SNP:exon:869T>C (rs1982073) (human)
RGD
PMID:18411002 PMID:19380441 PMID:19943923
RGD:4145121 RGD:4145136 RGD:4145278
NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046
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TNF
tumor necrosis factor
susceptibility
ISO
associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1799724(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415
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TNFRSF1A
TNF receptor superfamily member 1A
ISO
RGD
PMID:18347190
RGD:5131153
NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,051...64,331,909
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VTN
vitronectin
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr12:44,650,532...44,653,916
Ensembl chr12:44,650,534...44,655,355
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CD274
CD274 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28736328
NCBI chr 1:216,646,378...216,792,731
Ensembl chr 1:216,660,041...216,792,724
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CEBPA
CCAAT enhancer binding protein alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21346772
NCBI chr 6:43,083,200...43,085,884
Ensembl chr 6:43,083,207...43,085,836
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