RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Radiation Injuries
Accession: DOID:9000111
browse the term
Definition: Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.
Synonyms: exact_synonym: Radiation Injury; Radiation Sickness; Radiation Sicknesses; Radiation Syndrome; Radiation Syndromes; Radiation-induced nausea and vomiting
primary_id: MESH:D011832
xref: EFO:0006912 ; EFO:0009566
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Bdnf
brain derived neurotrophic factor
treatment
ISO
RGD
PMID:24333433
RGD:10059359
NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
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Csf2
colony stimulating factor 2 (granulocyte-macrophage)
IEP
mRNA:increased expression:bone marrow,spleen:
RGD
PMID:7662961
RGD:10449513
NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
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Gpx3
glutathione peroxidase 3
treatment
ISO
RGD
PMID:20105084
RGD:401827914
NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203
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Hif1a
hypoxia inducible factor 1, alpha subunit
treatment
ISO
RGD
PMID:17340073
RGD:8695920
NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
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Il1a
interleukin 1 alpha
ISO
RGD
PMID:7938676
RGD:7794763
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
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Mir122
microRNA 122
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32422326
NCBI chr18:65,381,932...65,381,997
Ensembl chr18:65,381,932...65,381,997
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Sod2
superoxide dismutase 2, mitochondrial
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16540396 PMID:21945096
NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
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Tgfbr2
transforming growth factor, beta receptor II
ISO
RGD
PMID:12957270
RGD:1601599
NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428
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Abcb1a
ATP-binding cassette, sub-family B member 1A
susceptibility
ISO
DNA:missense mutation:cds:p.G671V (human)
RGD
PMID:16330681
RGD:11041175
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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Acvr2b
activin receptor IIB
treatment
ISO
human construct in mouse model
RGD
PMID:30765322
RGD:329849112
NCBI chr 9:119,231,081...119,271,214
Ensembl chr 9:119,231,184...119,264,061
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Capn2
calpain 2
treatment
ISO
RGD
PMID:25634181
RGD:13792617
NCBI chr 1:182,294,818...182,345,175
Ensembl chr 1:182,294,825...182,345,173
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Ercc2
excision repair cross-complementing rodent repair deficiency, complementation group 2
ISO
associated with Leukemia, Myeloid, Acute;DNA:SNP:exon:p.K751Q (rs13181) (human)
RGD
PMID:24284041
RGD:11252190
NCBI chr 7:19,115,942...19,129,619
Ensembl chr 7:19,115,935...19,129,619
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Acacb
acetyl-Coenzyme A carboxylase beta
ISO
mRNA, protein:increased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822
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Agt
angiotensinogen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33676887
NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
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Bche
butyrylcholinesterase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:26145887
NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
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Bmp2
bone morphogenetic protein 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29800642
NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805
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Cat
catalase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:35792220
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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Ccl2
C-C motif chemokine ligand 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
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Cpt1a
carnitine palmitoyltransferase 1a, liver
ISO
mRNA, protein:decreased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733
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Csf1
colony stimulating factor 1 (macrophage)
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32068018
NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785
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Cxcl15
C-X-C motif chemokine ligand 15
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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Fas
Fas cell surface death receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34713381
NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
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Fasl
Fas ligand
ISO EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:34713381
NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
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Fto
FTO alpha-ketoglutarate dependent dioxygenase
ISO
DNA:hypermethylation:promoter
RGD
PMID:35462195
RGD:329951017
NCBI chr 8:92,039,995...92,395,061
Ensembl chr 8:92,040,153...92,395,067
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Hbegf
heparin-binding EGF-like growth factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29305325
NCBI chr18:36,637,980...36,648,858
Ensembl chr18:36,637,980...36,648,858
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Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32068018
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:32909839 PMID:33887967
NCBI chr18:45,401,754...45,818,954
Ensembl chr18:45,401,927...45,818,950
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Mettl14
methyltransferase 14, N6-adenosine-methyltransferase subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34648132
NCBI chr 3:123,161,944...123,179,639
Ensembl chr 3:123,161,946...123,179,757
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Mir143
microRNA 143
ameliorates
IMP
RGD
PMID:32170053
RGD:155883163
NCBI chr18:61,782,267...61,782,329
Ensembl chr18:61,782,267...61,782,329
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Mir208a
microRNA 208a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26454886
NCBI chr14:55,186,517...55,186,599
Ensembl chr14:55,186,517...55,186,599
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Mlycd
malonyl-CoA decarboxylase
ISO
protein:increased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr 8:120,121,591...120,148,577
Ensembl chr 8:120,121,617...120,137,841
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Nos3
nitric oxide synthase 3, endothelial cell
treatment
ISO
associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma;DNA:polymorphism: :894G>T(human)
RGD
PMID:26345518
RGD:11533645
NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
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Nppb
natriuretic peptide type B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662
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Nrg1
neuregulin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29305325
NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825 Ensembl chr 8:32,304,579...33,374,825
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Prkaa2
protein kinase, AMP-activated, alpha 2 catalytic subunit
ISO
protein:decreased expression:serum, heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087
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Rac1
Rac family small GTPase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28710503
NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791
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Rarg
retinoic acid receptor, gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26237429
NCBI chr15:102,143,373...102,165,891
Ensembl chr15:102,143,373...102,165,952
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Rnf10
ring finger protein 10
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:36740146
NCBI chr 5:115,379,829...115,410,951
Ensembl chr 5:115,379,471...115,410,957
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Sirt6
sirtuin 6
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:34713381
NCBI chr10:81,457,621...81,463,631
Ensembl chr10:81,457,619...81,463,631
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Tlr2
toll-like receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987 PMID:32068018
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Trp53
transformation related protein 53
EXP ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30009776 PMID:34713381
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
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Agtr1a
angiotensin II receptor, type 1a
ISO
RGD
PMID:14982483
RGD:6903857
NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
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Agtr2
angiotensin II receptor, type 2
ISO
RGD
PMID:14982483
RGD:6903857
NCBI chr X:21,350,863...21,355,072
Ensembl chr X:21,350,783...21,355,403
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Aif1
allograft inflammatory factor 1
ISO
protein:decreased expression:brain (rat)
RGD
PMID:19070908
RGD:2313024
NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044
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Casp3
caspase 3
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Casp8
caspase 8
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
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Casp9
caspase 9
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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Ccn2
cellular communication network factor 2
ISO
protein:increased expression:kidney (rat)
RGD
PMID:19080126
RGD:2314603
NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581
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Eng
endoglin
IMP ISO
kidney protein:decreased expression:lung (rat)
RGD
PMID:23022174 PMID:22151990
RGD:7248771 , RGD:7257525
NCBI chr 2:32,536,607...32,572,681
Ensembl chr 2:32,536,607...32,572,681
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Fas
Fas cell surface death receptor
ISO
mRNA:increased expression:testis (rat)
RGD
PMID:9927315
RGD:8662886
NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
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Hif1a
hypoxia inducible factor 1, alpha subunit
ISO
protein:increased expression:white matter of spinal cord (rat) CTD Direct Evidence: therapeutic
CTD RGD
PMID:23065176 PMID:15161688
RGD:9068912
NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
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Hmox1
heme oxygenase 1
treatment
ISO
RGD
PMID:22247972
RGD:10755582
NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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Ifng
interferon gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
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Igf2
insulin-like growth factor 2
ISO
mRNA:increased expression:brain
RGD
PMID:11213353
RGD:5509971
NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553
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Il10
interleukin 10
treatment
ISO
protein:increased expression:plasma
RGD
PMID:23788042 PMID:23968122
RGD:7365012 , RGD:11049496
NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
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Il18
interleukin 18
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
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Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Lcn2
lipocalin 2
ISO
mRNA,protein:increased expression:liver, heart, kidney,spleen, serum,
RGD
PMID:23331620
RGD:126790570
NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264
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Mapk1
mitogen-activated protein kinase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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Mapk3
mitogen-activated protein kinase 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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Mir122
microRNA 122
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32422326
NCBI chr18:65,381,932...65,381,997
Ensembl chr18:65,381,932...65,381,997
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Nos1
nitric oxide synthase 1, neuronal
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20726721
NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
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Pcna
proliferating cell nuclear antigen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21931560
NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
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Pecam1
platelet/endothelial cell adhesion molecule 1
ISO
mRNA:altered expression:jejunum, duodenum, ileum (rat)
RGD
PMID:22227376
RGD:6767294
NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454
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Ptgs1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:intestine
RGD
PMID:17699727
RGD:2290567
NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
protein:increased expression:intestine
RGD
PMID:17699727
RGD:2290567
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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Sod1
superoxide dismutase 1, soluble
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
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Sod2
superoxide dismutase 2, mitochondrial
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11121210 PMID:20726721
NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Ace
angiotensin I converting enzyme
treatment
ISO
RGD
PMID:8995730
RGD:12880012
NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790
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Serpine1
serine (or cysteine) peptidase inhibitor, clade E, member 1
treatment
ISO
RGD
PMID:8995730
RGD:12880012
NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
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Alox5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:1886988
RGD:4890434
NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139
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Atm
ataxia telangiectasia mutated
susceptibility
ISO
associated with lung cancer;DNA:SNPs:promoter:���111G>A,126713G>A (rs189037, s373759) (human)
RGD
PMID:20171797
RGD:150340755
NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
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C3
complement component 3
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
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C4bp
complement component 4 binding protein
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr 1:130,562,510...130,589,365
Ensembl chr 1:130,562,510...130,589,369
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Cblb
Casitas B-lineage lymphoma b
susceptibility
ISO
associated with lung non-small cell carcinoma; DNA:SNP,haplotype: :rs2305035(human)
RGD
PMID:26732495
RGD:150540334
NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411
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Ccl17
C-C motif chemokine ligand 17
ISO
mRNA, protein:increased expression:lung, alveolar macrophage
RGD
PMID:15293604
RGD:4145517
NCBI chr 8:95,535,996...95,538,666
Ensembl chr 8:95,537,081...95,538,664
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Ccl22
C-C motif chemokine ligand 22
ISO
mRNA, protein:increased expression:lung, alveolar macrophage
RGD
PMID:15293604
RGD:4145517
NCBI chr 8:95,472,312...95,478,016
Ensembl chr 8:95,472,218...95,478,327
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Il13
interleukin 13
susceptibility
ISO
associated with carcinoma, non-small-cell lung; DNA:SNPs: :rs20541, rs180925 (human)
RGD
PMID:20811626
RGD:5131286
NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
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Il1a
interleukin 1 alpha
susceptibility
ISO
associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1800587,rs17561(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
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Mif
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
susceptibility
ISO
associated with carcinoma, non-small-cell lung; DNA:SNP: :rs755622(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074
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Nos3
nitric oxide synthase 3, endothelial cell
susceptibility
ISO
associated with carcinoma, non-small-cell lung;DNA:SNP:cds:c.894G>T rs1799983 (human)
RGD
PMID:20811626
RGD:5131286
NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
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Sftpd
surfactant associated protein D
susceptibility
ISO
RGD
PMID:20459699
RGD:4143486
NCBI chr14:40,894,169...40,907,155
Ensembl chr14:40,894,171...40,907,106
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Tgfb1
transforming growth factor, beta 1
susceptibility
ISO
protein:increased expression:blood DNA:SNP:exon:869T>C (rs1982073) (human)
RGD
PMID:19943923 PMID:18411002 PMID:19380441
RGD:4145121 , RGD:4145278 , RGD:4145136
NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
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Tnf
tumor necrosis factor
susceptibility
ISO
associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1799724(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
IMP
RGD
PMID:18347190
RGD:5131153
NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447
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Vtn
vitronectin
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr11:78,389,946...78,393,151
Ensembl chr11:78,389,917...78,393,150
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Zp3r
zona pellucida 3 receptor
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr 1:130,474,847...130,557,371
Ensembl chr 1:130,504,450...130,557,358
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Cd274
CD274 antigen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28736328
NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495
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Cebpa
CCAAT/enhancer binding protein alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21346772
NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all