RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Radiation Injuries
Accession: DOID:9000111
browse the term
Definition: Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.
Synonyms: exact_synonym: Radiation Injury; Radiation Sickness; Radiation Sicknesses; Radiation Syndrome; Radiation Syndromes; Radiation-induced nausea and vomiting
primary_id: MESH:D011832
xref: EFO:0006912 ; EFO:0009566
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BDNF
brain derived neurotrophic factor
treatment
ISO
RGD
PMID:24333433
RGD:10059359
NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
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CSF2
colony stimulating factor 2
ISO
mRNA:increased expression:bone marrow,spleen:
RGD
PMID:7662961
RGD:10449513
NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
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GPX3
glutathione peroxidase 3
treatment
ISO
RGD
PMID:20105084
RGD:401827914
NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988
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HIF1A
hypoxia inducible factor 1 subunit alpha
treatment
IDA
RGD
PMID:17340073
RGD:8695920
NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
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IL1A
interleukin 1 alpha
ISO
RGD
PMID:7938676
RGD:7794763
NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
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MIR122
microRNA 122
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:32422326
NCBI chr18:58,451,074...58,451,158
Ensembl chr18:58,451,074...58,451,158
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SOD2
superoxide dismutase 2
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:16540396 PMID:21945096
NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
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TGFBR2
transforming growth factor beta receptor 2
ISO
RGD
PMID:12957270
RGD:1601599
NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,478...30,694,249
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ABCB1
ATP binding cassette subfamily B member 1
susceptibility
IAGP
DNA:missense mutation:cds:p.G671V (human)
RGD
PMID:16330681
RGD:11041175
NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
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ACVR2B
activin A receptor type 2B
treatment
IMP
human construct in mouse model
RGD
PMID:30765322
RGD:329849112
NCBI chr 3:38,453,890...38,493,142
Ensembl chr 3:38,453,890...38,493,142
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CAPN2
calpain 2
treatment
ISO
RGD
PMID:25634181
RGD:13792617
NCBI chr 1:223,701,597...223,776,018
Ensembl chr 1:223,701,593...223,776,018
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ERCC2
ERCC excision repair 2, TFIIH core complex helicase subunit
IAGP
associated with Leukemia, Myeloid, Acute;DNA:SNP:exon:p.K751Q (rs13181) (human)
RGD
PMID:24284041
RGD:11252190
NCBI chr19:45,349,837...45,370,573
Ensembl chr19:45,349,837...45,370,918
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ACACB
acetyl-CoA carboxylase beta
ISO
mRNA, protein:increased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr12:109,111,189...109,268,226
Ensembl chr12:109,116,587...109,268,226
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AGT
angiotensinogen
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:33676887
NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
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BCHE
butyrylcholinesterase
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:26145887
NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
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BMP2
bone morphogenetic protein 2
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:29800642
NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
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CAT
catalase
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:35792220
NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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CCL2
C-C motif chemokine ligand 2
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
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CPT1A
carnitine palmitoyltransferase 1A
ISO
mRNA, protein:decreased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410
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CSF1
colony stimulating factor 1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:32068018
NCBI chr 1:109,910,506...109,930,992
Ensembl chr 1:109,910,242...109,930,992
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CXCL8
C-X-C motif chemokine ligand 8
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
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FAS
Fas cell surface death receptor
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:34713381
NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
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FASLG
Fas ligand
EXP ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34713381
NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
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FTO
FTO alpha-ketoglutarate dependent dioxygenase
ISO
DNA:hypermethylation:promoter
RGD
PMID:35462195
RGD:329951017
NCBI chr16:53,703,963...54,121,941
Ensembl chr16:53,701,692...54,158,512
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HBEGF
heparin binding EGF like growth factor
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:29305325
NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603
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IL1B
interleukin 1 beta
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:32068018
NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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KCNN2
potassium calcium-activated channel subfamily N member 2
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:32909839 PMID:33887967
NCBI chr 5:114,055,978...114,496,496
Ensembl chr 5:114,055,926...114,496,500
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METTL14
methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:34648132
NCBI chr 4:118,685,392...118,715,430
Ensembl chr 4:118,685,392...118,715,433
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MIR143
microRNA 143
ameliorates
ISO
RGD
PMID:32170053
RGD:155883163
NCBI chr 5:149,428,918...149,429,023
Ensembl chr 5:149,428,918...149,429,023
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MIR208A
microRNA 208a
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:26454886
NCBI chr14:23,388,596...23,388,666
Ensembl chr14:23,388,596...23,388,666
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MLYCD
malonyl-CoA decarboxylase
ISO
protein:increased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr16:83,899,115...83,927,031
Ensembl chr16:83,899,115...83,951,445
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NOS3
nitric oxide synthase 3
treatment
IAGP
associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma;DNA:polymorphism: :894G>T(human)
RGD
PMID:26345518
RGD:11533645
NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
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NPPB
natriuretic peptide B
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
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NRG1
neuregulin 1
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:29305325
NCBI chr 8:31,639,245...32,774,046
Ensembl chr 8:31,639,222...32,855,666
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PRKAA2
protein kinase AMP-activated catalytic subunit alpha 2
ISO
protein:decreased expression:serum, heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr 1:56,645,314...56,715,335
Ensembl chr 1:56,645,314...56,715,335
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RAC1
Rac family small GTPase 1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:28710503
NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967
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RARG
retinoic acid receptor gamma
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:26237429
NCBI chr12:53,210,569...53,232,209
Ensembl chr12:53,210,567...53,232,980
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RNF10
ring finger protein 10
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:36740146
NCBI chr12:120,534,356...120,577,588
Ensembl chr12:120,533,480...120,577,588
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SIRT6
sirtuin 6
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:34713381
NCBI chr19:4,174,109...4,182,563
Ensembl chr19:4,174,109...4,182,566
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TLR2
toll like receptor 2
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,050...153,706,260
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TNF
tumor necrosis factor
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987 PMID:32068018
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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TP53
tumor protein p53
ISO EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:30009776 PMID:34713381
NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
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AGTR1
angiotensin II receptor type 1
ISO
RGD
PMID:14982483
RGD:6903857
NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
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AGTR2
angiotensin II receptor type 2
ISO
RGD
PMID:14982483
RGD:6903857
NCBI chr X:116,170,744...116,174,974
Ensembl chr X:116,170,744...116,174,974
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AIF1
allograft inflammatory factor 1
ISO
protein:decreased expression:brain (rat)
RGD
PMID:19070908
RGD:2313024
NCBI chr 6:31,615,234...31,617,015
Ensembl chr 6:31,615,217...31,617,021
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CASP3
caspase 3
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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CASP8
caspase 8
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
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CASP9
caspase 9
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
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CCN2
cellular communication network factor 2
ISO
protein:increased expression:kidney (rat)
RGD
PMID:19080126
RGD:2314603
NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372
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ENG
endoglin
ISO
kidney protein:decreased expression:lung (rat)
RGD
PMID:23022174 PMID:22151990
RGD:7248771 , RGD:7257525
NCBI chr 9:127,815,016...127,854,658
Ensembl chr 9:127,811,130...127,854,773
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FAS
Fas cell surface death receptor
ISO
mRNA:increased expression:testis (rat)
RGD
PMID:9927315
RGD:8662886
NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
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HIF1A
hypoxia inducible factor 1 subunit alpha
ISO EXP
protein:increased expression:white matter of spinal cord (rat) CTD Direct Evidence: therapeutic
CTD RGD
PMID:23065176 PMID:15161688
RGD:9068912
NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
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HMOX1
heme oxygenase 1
treatment
ISO
RGD
PMID:22247972
RGD:10755582
NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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IFNG
interferon gamma
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
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IGF2
insulin like growth factor 2
ISO
mRNA:increased expression:brain
RGD
PMID:11213353
RGD:5509971
NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391
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IL10
interleukin 10
treatment
ISO
protein:increased expression:plasma
RGD
PMID:23788042 PMID:23968122
RGD:7365012 , RGD:11049496
NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
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IL18
interleukin 18
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,251...112,164,096
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IL1B
interleukin 1 beta
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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LCN2
lipocalin 2
ISO
mRNA,protein:increased expression:liver, heart, kidney,spleen, serum,
RGD
PMID:23331620
RGD:126790570
NCBI chr 9:128,149,453...128,153,453
Ensembl chr 9:128,149,071...128,153,453
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MAPK1
mitogen-activated protein kinase 1
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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MAPK3
mitogen-activated protein kinase 3
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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MIR122
microRNA 122
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:32422326
NCBI chr18:58,451,074...58,451,158
Ensembl chr18:58,451,074...58,451,158
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NOS1
nitric oxide synthase 1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:20726721
NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
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PCNA
proliferating cell nuclear antigen
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:21931560
NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
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PECAM1
platelet and endothelial cell adhesion molecule 1
ISO
mRNA:altered expression:jejunum, duodenum, ileum (rat)
RGD
PMID:22227376
RGD:6767294
NCBI chr17:64,319,415...64,390,860
Ensembl chr17:64,319,415...64,413,776
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PTGS1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:intestine
RGD
PMID:17699727
RGD:2290567
NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703
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PTGS2
prostaglandin-endoperoxide synthase 2
ISO
protein:increased expression:intestine
RGD
PMID:17699727
RGD:2290567
NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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SOD1
superoxide dismutase 1
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
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SOD2
superoxide dismutase 2
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:11121210 PMID:20726721
NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
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TNF
tumor necrosis factor
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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ACE
angiotensin I converting enzyme
treatment
ISO
RGD
PMID:8995730
RGD:12880012
NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
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SERPINE1
serpin family E member 1
treatment
ISO
RGD
PMID:8995730
RGD:12880012
NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
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ALOX5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:1886988
RGD:4890434
NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119
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ATM
ATM serine/threonine kinase
susceptibility
IAGP
associated with lung cancer;DNA:SNPs:promoter:���111G>A,126713G>A (rs189037, s373759) (human)
RGD
PMID:20171797
RGD:150340755
NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,804...108,369,102
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C3
complement C3
IEP
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562
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C4BPA
complement component 4 binding protein alpha
IEP
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr 1:207,104,233...207,144,972
Ensembl chr 1:207,104,233...207,144,972
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CBLB
Cbl proto-oncogene B
susceptibility
IAGP
associated with lung non-small cell carcinoma; DNA:SNP,haplotype: :rs2305035(human)
RGD
PMID:26732495
RGD:150540334
NCBI chr 3:105,655,461...105,869,449
Ensembl chr 3:105,655,461...105,869,552
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CCL17
C-C motif chemokine ligand 17
ISO
mRNA, protein:increased expression:lung, alveolar macrophage
RGD
PMID:15293604
RGD:4145517
NCBI chr16:57,396,093...57,416,063
Ensembl chr16:57,404,767...57,416,063
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CCL22
C-C motif chemokine ligand 22
ISO
mRNA, protein:increased expression:lung, alveolar macrophage
RGD
PMID:15293604
RGD:4145517
NCBI chr16:57,357,909...57,366,189
Ensembl chr16:57,358,783...57,366,189
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IL13
interleukin 13
susceptibility
IAGP
associated with carcinoma, non-small-cell lung; DNA:SNPs: :rs20541, rs180925 (human)
RGD
PMID:20811626
RGD:5131286
NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
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IL1A
interleukin 1 alpha
susceptibility
IAGP
associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1800587,rs17561(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
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MIF
macrophage migration inhibitory factor
susceptibility
IAGP
associated with carcinoma, non-small-cell lung; DNA:SNP: :rs755622(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227
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NOS3
nitric oxide synthase 3
susceptibility
IAGP
associated with carcinoma, non-small-cell lung;DNA:SNP:cds:c.894G>T rs1799983 (human)
RGD
PMID:20811626
RGD:5131286
NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
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SFTPD
surfactant protein D
susceptibility
IEP
RGD
PMID:20459699
RGD:4143486
NCBI chr10:79,937,740...79,982,383
Ensembl chr10:79,937,467...79,982,614
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TGFB1
transforming growth factor beta 1
susceptibility
IEP ISO IAGP
protein:increased expression:blood DNA:SNP:exon:869T>C (rs1982073) (human)
RGD
PMID:19943923 PMID:18411002 PMID:19380441
RGD:4145121 , RGD:4145278 , RGD:4145136
NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
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TNF
tumor necrosis factor
susceptibility
IAGP
associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1799724(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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TNFRSF1A
TNF receptor superfamily member 1A
ISO
RGD
PMID:18347190
RGD:5131153
NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
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VTN
vitronectin
IEP
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr17:28,367,284...28,370,307
Ensembl chr17:28,367,284...28,373,091
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CD274
CD274 molecule
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:28736328
NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566
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CEBPA
CCAAT enhancer binding protein alpha
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:21346772
NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534
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