RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Radiation Injuries
Accession: DOID:9000111
browse the term
Definition: Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.
Synonyms: exact_synonym: Radiation Injury; Radiation Sickness; Radiation Sicknesses; Radiation Syndrome; Radiation Syndromes; Radiation-induced nausea and vomiting
primary_id: MESH:D011832
xref: EFO:0006912 ; EFO:0009566
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BDNF
brain derived neurotrophic factor
treatment
ISO
RGD
PMID:24333433
RGD:10059359
NCBI chr21:48,191,580...48,243,699
Ensembl chr21:48,192,670...48,204,480
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CSF2
colony stimulating factor 2
ISO
mRNA:increased expression:bone marrow,spleen:
RGD
PMID:7662961
RGD:10449513
NCBI chr11:20,342,880...20,346,959
Ensembl chr11:20,344,648...20,346,959
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GPX3
glutathione peroxidase 3
treatment
ISO
RGD
PMID:20105084
RGD:401827914
NCBI chr 4:58,200,671...58,209,010
Ensembl chr 4:58,200,672...58,209,010
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HIF1A
hypoxia inducible factor 1 subunit alpha
treatment
ISO
RGD
PMID:17340073
RGD:8695920
NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692
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IL1A
interleukin 1 alpha
ISO
RGD
PMID:7938676
RGD:7794763
NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435
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MIR122
microRNA mir-122
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32422326
NCBI chr 1:17,593,858...17,593,915
Ensembl chr 1:17,593,837...17,593,929
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SOD2
superoxide dismutase 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16540396 PMID:21945096
NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
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TGFBR2
transforming growth factor beta receptor 2
ISO
RGD
PMID:12957270
RGD:1601599
NCBI chr23:13,886,869...13,946,480
Ensembl chr23:13,889,000...13,977,636
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ABCB1
ATP binding cassette subfamily B member 1
susceptibility
ISO
DNA:missense mutation:cds:p.G671V (human)
RGD
PMID:16330681
RGD:11041175
NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
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ACVR2B
activin A receptor type 2B
treatment
ISO
human construct in mouse model
RGD
PMID:30765322
RGD:329849112
NCBI chr23:8,211,555...8,225,596
Ensembl chr23:8,192,483...8,218,894
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CAPN2
calpain 2
treatment
ISO
RGD
PMID:25634181
RGD:13792617
NCBI chr 7:40,333,379...40,367,158
Ensembl chr 7:40,334,012...40,377,037
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ERCC2
ERCC excision repair 2, TFIIH core complex helicase subunit
ISO
associated with Leukemia, Myeloid, Acute;DNA:SNP:exon:p.K751Q (rs13181) (human)
RGD
PMID:24284041
RGD:11252190
NCBI chr 1:110,173,781...110,191,612
Ensembl chr 1:110,173,715...110,190,125
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ACACB
acetyl-CoA carboxylase beta
ISO
mRNA, protein:increased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr26:17,763,531...17,895,319
Ensembl chr26:17,747,362...17,894,400
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AGT
angiotensinogen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33676887
NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
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BCHE
butyrylcholinesterase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:26145887
NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
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BMP2
bone morphogenetic protein 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29800642
NCBI chr24:15,199,667...15,211,509
Ensembl chr24:15,200,291...15,212,217
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CAT
catalase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:35792220
NCBI chr18:33,383,005...33,422,447
Ensembl chr18:33,383,005...33,422,447
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CCL2
C-C motif chemokine ligand 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr 9:39,008,187...39,009,932
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CPT1A
carnitine palmitoyltransferase 1A
ISO
mRNA, protein:decreased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr18:49,136,691...49,190,117
Ensembl chr18:49,136,691...49,190,117
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CSF1
colony stimulating factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32068018
NCBI chr 6:42,028,454...42,047,028
Ensembl chr 6:42,034,149...42,049,371
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CXCL8
C-X-C motif chemokine ligand 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354
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FAS
Fas cell surface death receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34713381
NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321
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FASLG
Fas ligand
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34713381
NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224
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FTO
FTO alpha-ketoglutarate dependent dioxygenase
ISO
DNA:hypermethylation:promoter
RGD
PMID:35462195
RGD:329951017
NCBI chr 2:61,699,864...62,080,199
Ensembl chr 2:61,652,236...62,080,059
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HBEGF
heparin binding EGF like growth factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29305325
NCBI chr 2:35,551,248...35,563,310
Ensembl chr 2:35,551,250...35,563,043
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IL1B
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32068018
NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458
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KCNN2
potassium calcium-activated channel subfamily N member 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:32909839 PMID:33887967
NCBI chr11:4,279,362...4,423,080
Ensembl chr11:4,154,746...4,423,078
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METTL14
methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34648132
NCBI chr32:37,653,163...37,679,577
Ensembl chr32:37,653,035...37,678,398
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MIR143
microRNA mir-143
ameliorates
ISO
RGD
PMID:32170053
RGD:155883163
NCBI chr 4:59,534,535...59,534,589
Ensembl chr 4:59,534,535...59,534,594
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MIR208A
microRNA mir-208a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26454886
NCBI chr 8:3,636,919...3,636,987
Ensembl chr 8:3,636,919...3,636,987
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MLYCD
malonyl-CoA decarboxylase
ISO
protein:increased expression:heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr 5:68,385,058...68,399,965
Ensembl chr 5:68,384,618...68,399,965
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NOS3
nitric oxide synthase 3
treatment
ISO
associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma;DNA:polymorphism: :894G>T(human)
RGD
PMID:26345518
RGD:11533645
NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
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NPPB
natriuretic peptide B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr 2:84,395,844...84,397,473
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NRG1
neuregulin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29305325
NCBI chr16:31,697,958...32,771,888
Ensembl chr16:31,706,851...32,771,932
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PRKAA2
protein kinase AMP-activated catalytic subunit alpha 2
ISO
protein:decreased expression:serum, heart (rat)
RGD
PMID:30644033
RGD:329955369
NCBI chr 5:52,809,792...52,855,072
Ensembl chr 5:52,815,609...52,876,609
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RAC1
Rac family small GTPase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28710503
NCBI chr 6:11,726,259...11,758,532
Ensembl chr 6:11,655,494...11,757,216
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RARG
retinoic acid receptor gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26237429
NCBI chr27:1,958,432...1,978,471
Ensembl chr27:1,958,204...1,978,476
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RNF10
ring finger protein 10
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:36740146
NCBI chr26:16,426,220...16,461,478
Ensembl chr26:16,426,234...16,547,119
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SIRT6
sirtuin 6
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:34713381
NCBI chr20:55,412,989...55,424,944
Ensembl chr20:55,412,646...55,424,944
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TLR2
toll like receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987
NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241
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TNF
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29959987 PMID:32068018
NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
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TP53
tumor protein p53
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30009776 PMID:34713381
NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109
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AGTR1
angiotensin II receptor type 1
ISO
RGD
PMID:14982483
RGD:6903857
NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238
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AGTR2
angiotensin II receptor type 2
ISO
RGD
PMID:14982483
RGD:6903857
NCBI chr X:88,703,551...88,708,451
Ensembl chr X:88,705,765...88,706,853
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AIF1
allograft inflammatory factor 1
ISO
protein:decreased expression:brain (rat)
RGD
PMID:19070908
RGD:2313024
NCBI chr12:1,104,350...1,106,179
Ensembl chr12:1,104,394...1,106,177
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CASP3
caspase 3
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
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CASP8
caspase 8
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822
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CASP9
caspase 9
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chr 2:82,033,759...82,076,710
Ensembl chr 2:82,031,563...82,090,484
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CCN2
cellular communication network factor 2
ISO
protein:increased expression:kidney (rat)
RGD
PMID:19080126
RGD:2314603
NCBI chr 1:25,508,082...25,511,058
Ensembl chr 1:25,507,662...25,510,145
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ENG
endoglin
ISO
protein:decreased expression:lung (rat) kidney
RGD
PMID:22151990 PMID:23022174
RGD:7248771 RGD:7257525
NCBI chr 9:55,558,246...55,590,081
Ensembl chr 9:55,558,305...55,589,064
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FAS
Fas cell surface death receptor
ISO
mRNA:increased expression:testis (rat)
RGD
PMID:9927315
RGD:8662886
NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321
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HIF1A
hypoxia inducible factor 1 subunit alpha
ISO
protein:increased expression:white matter of spinal cord (rat) CTD Direct Evidence: therapeutic
RGD CTD
PMID:15161688 PMID:23065176
RGD:9068912
NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692
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HMOX1
heme oxygenase 1
treatment
ISO
RGD
PMID:22247972
RGD:10755582
NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773
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IFNG
interferon gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698
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IGF2
insulin like growth factor 2
ISO
mRNA:increased expression:brain
RGD
PMID:11213353
RGD:5509971
NCBI chr18:46,294,036...46,311,982
Ensembl chr18:46,294,019...46,311,982
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IL10
interleukin 10
treatment
ISO
protein:increased expression:plasma
RGD
PMID:23788042 PMID:23968122
RGD:11049496 RGD:7365012
NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057
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IL18
interleukin 18
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348
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IL1B
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458
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LCN2
lipocalin 2
ISO
mRNA,protein:increased expression:liver, heart, kidney,spleen, serum,
RGD
PMID:23331620
RGD:126790570
NCBI chr 9:55,328,118...55,342,535
Ensembl chr 9:55,328,133...55,332,038
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MAPK1
mitogen-activated protein kinase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
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MAPK3
mitogen-activated protein kinase 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
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MIR122
microRNA mir-122
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32422326
NCBI chr 1:17,593,858...17,593,915
Ensembl chr 1:17,593,837...17,593,929
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NOS1
nitric oxide synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20726721
NCBI chr26:13,787,341...13,895,176
Ensembl chr26:13,786,309...13,962,332
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PCNA
proliferating cell nuclear antigen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21931560
NCBI chr24:16,478,774...16,485,992
Ensembl chr24:16,478,769...16,484,992
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PECAM1
platelet and endothelial cell adhesion molecule 1
ISO
mRNA:altered expression:jejunum, duodenum, ileum (rat)
RGD
PMID:22227376
RGD:6767294
NCBI chr 9:12,166,124...12,219,553
Ensembl chr 9:12,166,775...12,219,778
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PTGS1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:intestine
RGD
PMID:17699727
RGD:2290567
NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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PTGS2
prostaglandin-endoperoxide synthase 2
ISO
protein:increased expression:intestine
RGD
PMID:17699727
RGD:2290567
NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
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SOD1
superoxide dismutase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815
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SOD2
superoxide dismutase 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11121210 PMID:20726721
NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
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TNF
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
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ACE
angiotensin I converting enzyme
treatment
ISO
RGD
PMID:8995730
RGD:12880012
NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358
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SERPINE1
serpin family E member 1
treatment
ISO
RGD
PMID:8995730
RGD:12880012
NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301
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ALOX5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:1886988
RGD:4890434
NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609
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ATM
ATM serine/threonine kinase
susceptibility
ISO
associated with lung cancer;DNA:SNPs:promoter:���111G>A,126713G>A (rs189037, s373759) (human)
RGD
PMID:20171797
RGD:150340755
NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207
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B9D2
B9 domain containing 2
susceptibility
ISO
DNA:SNP:exon:869T>C (rs1982073) (human) protein:increased expression:blood
RGD
PMID:18411002 PMID:19380441 PMID:19943923
RGD:4145121 RGD:4145136 RGD:4145278
NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885
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C3
complement C3
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761
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C4BPA
complement component 4 binding protein alpha
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr 7:6,239,036...6,268,934
Ensembl chr 7:6,241,102...6,268,910
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CBLB
Cbl proto-oncogene B
susceptibility
ISO
associated with lung non-small cell carcinoma; DNA:SNP,haplotype: :rs2305035(human)
RGD
PMID:26732495
RGD:150540334
NCBI chr33:11,255,453...11,665,755
Ensembl chr33:11,199,863...11,530,810
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CCL17
C-C motif chemokine ligand 17
ISO
mRNA, protein:increased expression:lung, alveolar macrophage
RGD
PMID:15293604
RGD:4145517
NCBI chr 2:59,001,463...59,014,347
Ensembl chr 2:59,001,464...59,005,230
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CCL22
C-C motif chemokine ligand 22
ISO
mRNA, protein:increased expression:lung, alveolar macrophage
RGD
PMID:15293604
RGD:4145517
NCBI chr 2:59,039,650...59,045,519
Ensembl chr 2:59,040,539...59,045,625
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IL13
interleukin 13
susceptibility
ISO
associated with carcinoma, non-small-cell lung; DNA:SNPs: :rs20541, rs180925 (human)
RGD
PMID:20811626
RGD:5131286
NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388
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IL1A
interleukin 1 alpha
susceptibility
ISO
associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1800587,rs17561(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435
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MIF
macrophage migration inhibitory factor
susceptibility
ISO
associated with carcinoma, non-small-cell lung; DNA:SNP: :rs755622(human)
RGD
PMID:20811626
RGD:5131286
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NOS3
nitric oxide synthase 3
susceptibility
ISO
associated with carcinoma, non-small-cell lung;DNA:SNP:cds:c.894G>T rs1799983 (human)
RGD
PMID:20811626
RGD:5131286
NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
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SFTPD
surfactant protein D
susceptibility
ISO
RGD
PMID:20459699
RGD:4143486
NCBI chr 4:29,394,755...29,407,499
Ensembl chr 4:29,394,678...29,407,293
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TNF
tumor necrosis factor
susceptibility
ISO
associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1799724(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
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TNFRSF1A
TNF receptor superfamily member 1A
ISO
RGD
PMID:18347190
RGD:5131153
NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282
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VTN
vitronectin
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr 9:42,617,860...42,620,825
Ensembl chr 9:42,614,941...42,630,864
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CD274
CD274 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28736328
NCBI chr 1:93,461,735...93,605,772
Ensembl chr 1:93,585,518...93,603,522
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CEBPA
CCAAT enhancer binding protein alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21346772
NCBI chr 1:118,846,252...118,851,045
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