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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Lymphatic Metastasis
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Accession:DOID:9000081 term browser browse the term
Definition:Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Synonyms:exact_synonym: Lymphatic Metastases
 narrow_synonym: lymph node metastatic carcinoma
 primary_id: MESH:D008207;   RDO:0006041
 xref: EFO:0004906;   EFO:1001364

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Lymphatic Metastasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam28 ADAM metallopeptidase domain 28 ISO associated with breast cancer;DNA:hypermethylation: RGD PMID:25620615 RGD:153298970 NCBI chrNW_004936555:7,615,639...7,660,776
Ensembl chrNW_004936555:7,617,822...7,664,215 		JBrowse link
G Aicda activation induced cytidine deaminase ISO associated with stomach cancer;protein:increased expression:stomach (human) RGD PMID:21538122 RGD:127285638 NCBI chrNW_004936870:25,039...34,601
Ensembl chrNW_004936870:25,039...34,601 		JBrowse link
G Angptl4 angiopoietin like 4 ISO CTD Direct Evidence: therapeutic CTD PMID:17130448 NCBI chrNW_004936588:5,188,866...5,194,924
Ensembl chrNW_004936588:5,188,850...5,194,931 		JBrowse link
G Anxa1 annexin A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chrNW_004936503:9,124,314...9,142,372
Ensembl chrNW_004936503:9,124,264...9,142,413 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:21401805 NCBI chrNW_004936524:1,963,427...1,969,977
Ensembl chrNW_004936524:1,963,247...1,969,998 		JBrowse link
G Arhgap5 Rho GTPase activating protein 5 ISO associated with nasopharynx carcinoma;mRNA, protein:increased expression: epithelium of nasopharynx RGD PMID:25961434 RGD:11056278 NCBI chrNW_004936494:6,562,092...6,624,015
Ensembl chrNW_004936494:6,562,069...6,623,175 		JBrowse link
G Asxl1 ASXL transcriptional regulator 1 ISO associated with colorectal cancer RGD PMID:32317519 RGD:126779580 NCBI chrNW_004936485:19,218,494...19,297,188
Ensembl chrNW_004936485:19,227,400...19,298,912 		JBrowse link
G Axl AXL receptor tyrosine kinase ISO associated Pancreatic Neoplasms RGD PMID:19252414 RGD:2325833 NCBI chrNW_004936661:3,658,140...3,687,290
Ensembl chrNW_004936661:3,657,831...3,687,816 		JBrowse link
G Bag1 BAG cochaperone 1 disease_progression ISO associated with Breast Neoplasms:protein:increased expression:breast RGD PMID:18430249 RGD:2292908 NCBI chrNW_004936524:1,793,001...1,804,145
Ensembl chrNW_004936524:1,791,119...1,804,151 		JBrowse link
G Bambi BMP and activin membrane bound inhibitor ISO associated with stomach cancer; protein:increased expression: : RGD PMID:24752577 RGD:14390158 NCBI chrNW_004936613:3,098,549...3,103,868
Ensembl chrNW_004936613:3,098,159...3,103,868 		JBrowse link
G Barhl2 BarH like homeobox 2 ISO associated with oral squamous cell carcinoma; mRNA:decreased expression:mouth mucosa RGD PMID:27542258 RGD:14390167 NCBI chrNW_004936537:8,129,213...8,134,744
Ensembl chrNW_004936537:8,129,207...8,135,237 		JBrowse link
G Bcl2 BCL2 apoptosis regulator ISO associated with Breast Neoplasms;protein:increased expression:lymph node RGD PMID:18217456 RGD:2293013 NCBI chrNW_004936497:2,209,136...2,373,580
Ensembl chrNW_004936497:2,210,334...2,210,921 		JBrowse link
G Bik BCL2 interacting killer ISO associated with cholangiocarcinoma;DNA:CNV:: RGD PMID:16865775 RGD:14394820
G Birc5 baculoviral IAP repeat containing 5 disease_progression ISO associated with Breast Neoplasms
associated with Cervix Neoplasms;mRNA:splice variant		 RGD PMID:17285241 PMID:17877643 RGD:2293098 RGD:2293103 NCBI chrNW_004936594:2,812,165...2,820,618
Ensembl chrNW_004936594:2,812,238...2,820,636 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29426936 NCBI chrNW_004936592:4,728,371...4,833,830
Ensembl chrNW_004936592:4,737,011...4,834,664 		JBrowse link
G Brd7 bromodomain containing 7 severity ISO protein:increased expression:lung: RGD PMID:22008115 RGD:9586442 NCBI chrNW_004936475:3,394,423...3,432,998
Ensembl chrNW_004936475:3,393,373...3,433,103 		JBrowse link
G Bsg basigin (Ok blood group) disease_progression ISO associated with Breast Neoplasms RGD PMID:16004819 RGD:2289055 NCBI chrNW_004936588:181,688...189,795
Ensembl chrNW_004936588:181,576...189,287 		JBrowse link
G Btk Bruton tyrosine kinase disease_progression ISO associated with lung adenocarcinoma;protein:increased expression:lung (human) RGD PMID:31200752 RGD:151347847 NCBI chrNW_004936813:429,400...467,481
Ensembl chrNW_004936813:429,224...463,441 		JBrowse link
G Ca9 carbonic anhydrase 9 ISO associated with Cervix Neoplasms RGD PMID:17233814 RGD:2293196 NCBI chrNW_004936524:3,672,393...3,678,630
Ensembl chrNW_004936524:3,672,541...3,678,433 		JBrowse link
G Cab39 calcium binding protein 39 ISO associated with pancreatic cancer;RNA:increased expression:pancreas RGD PMID:28197410 RGD:14398834 NCBI chrNW_004936525:5,955,252...6,002,917
Ensembl chrNW_004936525:5,954,978...6,032,644 		JBrowse link
G Casp9 caspase 9 ISO associated with Carcinoma, Non-Small-Cell Lung;DNA:SNP:exon:rs1052576 (human) RGD PMID:17285546 RGD:13434907 NCBI chrNW_004936474:3,178,097...3,196,130 JBrowse link
G Cav1 caveolin 1 disease_progression ISO associated with Melanoma RGD PMID:22134245 RGD:8661767 NCBI chrNW_004936589:2,504,235...2,536,778
Ensembl chrNW_004936589:2,504,224...2,537,170 		JBrowse link
G Cbl Cbl proto-oncogene ISO associated with stomach carcinoma;protein:increased expression:stomach RGD PMID:31611438 RGD:126925223 NCBI chrNW_004936542:4,136,389...4,235,746
Ensembl chrNW_004936542:4,136,511...4,228,288 		JBrowse link
G Cblb Cbl proto-oncogene B ISO associated with stomach carcinoma; RGD PMID:20038312 RGD:150540338 NCBI chrNW_004936701:1,157,790...1,353,375
Ensembl chrNW_004936701:1,157,797...1,353,388 		JBrowse link
G Ccnd2 cyclin D2 ISO associated with colorectal cancer;protein:increased expression:colorectum RGD PMID:19508551 RGD:151665111 NCBI chrNW_004936606:4,474,801...4,496,158
Ensembl chrNW_004936606:4,474,749...4,496,810 		JBrowse link
G Ccne1 cyclin E1 ISO associated with Carcinoma, Transitional Cell;protein:decreased expression RGD PMID:16949911 RGD:2289266 NCBI chrNW_004936570:5,536,817...5,547,880
Ensembl chrNW_004936570:5,536,672...5,548,008 		JBrowse link
G Ccnh cyclin H ISO CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chrNW_004936469:5,933,163...5,952,190
Ensembl chrNW_004936469:5,935,131...5,952,460 		JBrowse link
G Cd274 CD274 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:16530813 NCBI chrNW_004936539:132,870...145,288
Ensembl chrNW_004936539:132,868...143,602 		JBrowse link
G Cd40 CD40 molecule ISO associated with breast cancer;DNA:snps:5' utr, intron:c.-1T>C, c.51+914T>G (rs1883832, rs4810485) (human) RGD PMID:21912605 RGD:8547780 NCBI chrNW_004936514:6,936,915...6,947,246
Ensembl chrNW_004936514:6,936,572...6,947,280 		JBrowse link
G Cd44 CD44 molecule (IN blood group) ISO associated with Breast Neoplasms, Colorectal Neoplasms, Stomach Neoplasms;mRNA, protein:splice variant, increased expression:breast, large intestine, stomach RGD PMID:16425351 RGD:2289356 NCBI chrNW_004936533:2,949,026...3,033,166 JBrowse link
G Cdh1 cadherin 1 ISO associated with Breast Neoplasms
associated with Cervix Neoplasms		 RGD PMID:17649807 PMID:18097581 RGD:2289498 RGD:2296046 NCBI chrNW_004936475:18,990,529...19,065,954
Ensembl chrNW_004936475:18,990,474...19,067,203 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A ISO associated with Eyelid Neoplasms;
associated with Oral Squamous Cell Carcinoma;		 RGD PMID:15817070 PMID:19628749 RGD:8661799 RGD:8662374 NCBI chrNW_004936476:22,717,308...22,725,127
Ensembl chrNW_004936476:22,717,260...22,725,182 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B ISO associated with Breast Neoplasms
associated with non-small cell lung carcinoma		 RGD PMID:12015771 PMID:28601655 RGD:13673921 RGD:2293607 NCBI chrNW_004936587:4,573,166...4,578,480
Ensembl chrNW_004936587:4,572,728...4,578,461 		JBrowse link
G Cldn1 claudin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33665778 NCBI chrNW_004936578:98,489...113,125
Ensembl chrNW_004936578:98,273...113,153 		JBrowse link
G Clptm1l CLPTM1 like ISO associated with esophagus squamous cell carcinoma; mRNA:increased expression:esophagus RGD PMID:25480402 RGD:150530497 NCBI chrNW_004936815:421,996...445,577
Ensembl chrNW_004936815:428,920...445,750 		JBrowse link
G Clu clusterin ISO associated with breast cancer;DNA:snp:promoter:g.27611345C>G (rs9331888) (human) RGD PMID:22037783 RGD:8963167 NCBI chrNW_004936675:499,745...513,515
Ensembl chrNW_004936675:499,199...513,836 		JBrowse link
G Comt catechol-O-methyltransferase ISO associated with breast cancer;DNA:missense mutation:cds:p.V108/158M (human) RGD PMID:10755383 RGD:8662330 NCBI chrNW_004936619:3,847,059...3,883,866
Ensembl chrNW_004936619:3,876,299...3,882,747 		JBrowse link
G Crp C-reactive protein susceptibility ISO associated with Breast Neoplasm; DNA:polymorphism: :1846C>T(rs1205)(human) RGD PMID:24633920 RGD:9580226 NCBI chrNW_004936740:885,855...888,854
Ensembl chrNW_004936740:883,272...890,606 		JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO associated with Breast Neoplasms RGD PMID:14734466 RGD:2293711 NCBI chrNW_004936504:4,898,947...4,927,195
Ensembl chrNW_004936504:4,898,945...4,928,923 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 ISO associated with Prostatic Neoplasms RGD PMID:10611340 RGD:4891523 NCBI chrNW_004936631:484,356...489,643
Ensembl chrNW_004936631:484,356...489,643 		JBrowse link
G Ctnna1 catenin alpha 1 ISO associated with Breast Neoplasms RGD PMID:12047765 RGD:2289795 NCBI chrNW_004936531:7,865,907...8,036,020
Ensembl chrNW_004936531:7,865,820...8,037,935 		JBrowse link
G Ctnnb1 catenin beta 1 ISO associated with Breast Neoplasms;protein:decreased expression RGD PMID:17908479 RGD:2289813 NCBI chrNW_004936473:29,999,542...30,034,610
Ensembl chrNW_004936473:29,999,562...30,038,293 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 disease_progression ISO associated with stomach cancer;mRNA:increased expression:stomach (human) RGD PMID:21633638 RGD:152023624 NCBI chrNW_004936617:4,224,131...4,239,080
Ensembl chrNW_004936617:4,224,131...4,238,796 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO associated with nasopharynx carcinoma; protein:increased expression:lymph node (human) RGD PMID:16000558 RGD:151893515 NCBI chrNW_004936469:39,794,613...39,798,448
Ensembl chrNW_004936469:39,794,584...39,798,459 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 severity ISO mRNA, protein:increased expression:mouth (human)
mRNA:increased expression:kidney, lymph nodes (human)		 RGD PMID:27020590 PMID:31253192 RGD:151347620 RGD:151347863 NCBI chrNW_004936837:523,227...538,799
Ensembl chrNW_004936837:523,266...538,833 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 disease_progression ISO associated with oral squamous cell carcinoma RGD PMID:29945346 RGD:150429700 NCBI chrNW_004936831:799,948...946,139
Ensembl chrNW_004936831:865,965...946,139 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta ISO associated with Carcinoma, Pancreatic Ductal; RGD PMID:22919364 RGD:9589121 NCBI chrNW_004936485:19,547,836...19,570,716 JBrowse link
G Ebag9 estrogen receptor binding site associated antigen 9 ISO associated with Breast Neoplasms;protein:increased expression:breast
associated with Prostatic Neoplasm;protein:increased expression:prostate gland, lymph node		 RGD PMID:12054692 PMID:12845666 PMID:17187007 RGD:2289847 RGD:2289856 RGD:2298489 NCBI chrNW_004936470:35,449,920...35,473,635
Ensembl chrNW_004936470:35,450,292...35,473,110 		JBrowse link
G Egfr epidermal growth factor receptor treatment ISO associated with Squamous Cell Carcinoma of the Tongue RGD PMID:19380367 RGD:8551769 NCBI chrNW_004936678:365,005...560,546
Ensembl chrNW_004936678:365,834...436,528 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 ISO associated with Melanoma;
associated with Esophageal Squamous Cell Carcinoma;		 RGD PMID:24658378 PMID:24805087 RGD:9590069 RGD:9590071 NCBI chrNW_004936727:1,648,451...1,663,294
Ensembl chrNW_004936727:1,648,448...1,663,455 		JBrowse link
G Epha2 EPH receptor A2 ISO protein:increased expression:esophagus (human) RGD PMID:33833989 RGD:153344568 NCBI chrNW_004936474:3,648,395...3,673,856
Ensembl chrNW_004936474:3,648,550...3,673,861 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 disease_progression ISO associated with Carcinoma, Transitional Cell;protein:increased expression:urinary bladder
associated with lung adenocarcinoma; protein:increased expression:lung (human)
CTD Direct Evidence: marker/mechanism
associated with Breast Neoplasms;DNA, protein:polymorphism, increased expression:serum:p.I655V		 RGD
CTD		 PMID:18097576 PMID:18237248 PMID:21532492 PMID:21966491 RGD:153344600 RGD:2289925 RGD:2289926 NCBI chrNW_004936490:14,887,062...14,910,038
Ensembl chrNW_004936490:14,887,043...14,909,956 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO associated with Prostatic Neoplasms;protein:increased expression, altered localization:lymph node, nucleus
associated with head and neck squamous cell carcinoma		 RGD PMID:17634423 PMID:20604875 RGD:126790467 RGD:2289944 NCBI chrNW_004936646:497,783...515,247
Ensembl chrNW_004936646:498,749...513,297 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 severity
disease_progression		 ISO associated with oral squamous cell carcinoma
associated with colorectal adenocarcinoma
associated with lung non-small cell carcinoma		 RGD PMID:16507107 PMID:21324275 PMID:27444519 RGD:126781762 RGD:126781766 RGD:126790471 NCBI chrNW_004936586:4,065,767...5,100,690
Ensembl chrNW_004936586:4,066,498...5,100,035 		JBrowse link
G Fas Fas cell surface death receptor susceptibility ISO associated with Cervix Neoplasms;DNA:polymorphism:promoter:-1377G>A RGD PMID:18068525 RGD:2298509 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Fgf1 fibroblast growth factor 1 ISO associated with Cervix Neoplasms;mRNA:increased expression:lymph node RGD PMID:17242701 RGD:2290286 NCBI chrNW_004936504:11,590,687...11,684,410
Ensembl chrNW_004936504:11,590,637...11,685,194 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 ISO associated with breast cancer;DNA:snp:intron:c.109+7033T>A (rs1219648) (human) RGD PMID:20640597 RGD:7394846 NCBI chrNW_004936486:10,506,680...10,606,272
Ensembl chrNW_004936486:10,507,097...10,602,019 		JBrowse link
G Flt3 fms related receptor tyrosine kinase 3 disease_progression ISO associated with Prostatic Neoplasms RGD PMID:14566827 RGD:2302210 NCBI chrNW_004936472:23,169,967...23,239,178
Ensembl chrNW_004936472:23,170,470...23,256,904 		JBrowse link
G Foxa1 forkhead box A1 ISO associated with lung non-small cell carcinoma; mRNA:increased expression: : RGD PMID:29115441 RGD:151665751 NCBI chrNW_004936494:11,529,546...11,535,224
Ensembl chrNW_004936494:11,529,546...11,535,224 		JBrowse link
G Foxp1 forkhead box P1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25485836 NCBI chrNW_004936603:2,631,781...3,146,104
Ensembl chrNW_004936603:2,632,274...2,830,324 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO associated with stomach carcinoma; DNA:hypermethylation:promoter RGD PMID:23071548 RGD:151665353 NCBI chrNW_004936647:3,904,787...3,914,223
Ensembl chrNW_004936647:3,906,113...3,913,498 		JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chrNW_004936651:2,756,559...3,401,806
Ensembl chrNW_004936651:2,762,380...3,401,808 		JBrowse link
G Hmgb1 high mobility group box 1 ISO associated with Adenocarcinoma, Colon RGD PMID:20616616 RGD:10402080 NCBI chrNW_004936472:25,236,728...25,246,585
Ensembl chrNW_004936472:25,236,728...25,246,580 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO associated with Breast Neoplasms RGD PMID:21590495 RGD:8547712 NCBI chrNW_004936659:616,570...627,172
Ensembl chrNW_004936659:616,752...627,174 		JBrowse link
G Ier2 immediate early response 2 ISO RGD PMID:22120713 RGD:153323322 NCBI chrNW_004936659:2,176,962...2,179,900
Ensembl chrNW_004936659:2,178,312...2,178,983 		JBrowse link
G Il13 interleukin 13 ISO associated with Melanoma, Cutaneous Malignant;mRNA:increased expression:lymph node RGD PMID:17545514 RGD:8549587 NCBI chrNW_004936647:2,529,933...2,532,503
Ensembl chrNW_004936647:2,530,491...2,532,373 		JBrowse link
G Il18 interleukin 18 ISO associated with Breast Neoplasms;protein:increased expression:serum RGD PMID:12902898 RGD:8655867 NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189 		JBrowse link
G Ing4 inhibitor of growth family member 4 ISO CTD Direct Evidence: therapeutic CTD PMID:27806345 NCBI chrNW_004936709:1,140,485...1,147,982
Ensembl chrNW_004936709:1,140,345...1,149,843 		JBrowse link
G Iqsec1 IQ motif and Sec7 domain ArfGEF 1 disease_progression ISO associated with lung adenocarcinoma; protein:increased expression:lung (human) RGD PMID:21966491 RGD:153344600 NCBI chrNW_004936898:318,564...425,785
Ensembl chrNW_004936898:337,400...425,859 		JBrowse link
G Itgb1 integrin subunit beta 1 ISO associated with non-small cell lung carcinoma, RGD PMID:28537888 RGD:13792830 NCBI chrNW_004936574:1,465,981...1,495,717
Ensembl chrNW_004936574:1,465,897...1,495,762 		JBrowse link
G Kcnj12 potassium inwardly rectifying channel subfamily J member 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34755307 NCBI chrNW_004936741:266,311...303,947 JBrowse link
G Kdr kinase insert domain receptor treatment ISO associated with Squamous Cell Carcinoma of the Tongue RGD PMID:19380367 RGD:8551769 NCBI chrNW_004936482:17,537,697...17,581,320
Ensembl chrNW_004936482:17,538,864...17,581,002 		JBrowse link
G Kiss1 KiSS-1 metastasis suppressor ISO CTD Direct Evidence: therapeutic CTD PMID:21383688 NCBI chrNW_004936567:584,443...595,045
Ensembl chrNW_004936567:584,443...586,837 		JBrowse link
G Klf7 KLF transcription factor 7 ISO CTD Direct Evidence: therapeutic CTD PMID:37734194 NCBI chrNW_004936631:3,327,555...3,412,206
Ensembl chrNW_004936631:3,329,681...3,412,252 		JBrowse link
G Kmt2d lysine methyltransferase 2D ISO associated with stomach cancer RGD PMID:30177394 RGD:150521710 NCBI chrNW_004936512:6,819,240...6,860,852
Ensembl chrNW_004936512:6,822,057...6,854,451 		JBrowse link
G Lamc2 laminin subunit gamma 2 ISO associated with lung squamous cell carcinoma; RGD PMID:23124251 RGD:13793371 NCBI chrNW_004936481:6,588,797...6,647,167
Ensembl chrNW_004936481:6,588,865...6,647,188 		JBrowse link
G LOC101964702 adhesion G protein-coupled receptor B1 disease_progression ISO associated with stomach cancer; RGD PMID:11172604 RGD:13831357 NCBI chrNW_004936470:9,247,749...9,313,230
Ensembl chrNW_004936470:9,248,319...9,313,230 		JBrowse link
G Lrrc59 leucine rich repeat containing 59 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chrNW_004936490:11,296,590...11,308,379
Ensembl chrNW_004936490:11,296,530...11,310,946 		JBrowse link
G Macir macrophage immunometabolism regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chrNW_004936523:1,273,812...1,292,837
Ensembl chrNW_004936523:1,275,214...1,292,854 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29426936 NCBI chrNW_004936589:2,280,803...2,390,179
Ensembl chrNW_004936589:2,280,799...2,390,179 		JBrowse link
G Mmp2 matrix metallopeptidase 2 disease_progression ISO associated with Carcinoma, Ductal, Breast
associated with Tongue Neoplasms		 RGD PMID:23107277 PMID:23280016 RGD:8547824 RGD:8655998 NCBI chrNW_004936475:7,801,356...7,825,831
Ensembl chrNW_004936475:7,801,277...7,825,851 		JBrowse link
G Mmp9 matrix metallopeptidase 9 disease_progression ISO associated with Tongue Neoplasms
associated with Carcinoma, Non-Small-Cell Lung;protein:increased expression:serum
associated with Endometrial Neoplasms;protein:increased expression:endometrium		 RGD PMID:12487935 PMID:20704821 PMID:23107277 RGD:2298523 RGD:5129215 RGD:8547824 NCBI chrNW_004936514:7,038,240...7,045,873
Ensembl chrNW_004936514:7,037,639...7,045,793 		JBrowse link
G Msh2 mutS homolog 2 ISO associated with laryngeal squamous cell carcinoma RGD PMID:24459922 RGD:126848797 NCBI chrNW_004936508:4,943,987...5,013,356
Ensembl chrNW_004936508:4,944,007...5,013,356 		JBrowse link
G Mta1 metastasis associated 1 ISO associated with Carcinoma, Non-Small-Cell Lung;mRNA:increased expression:lung RGD PMID:11804687 RGD:9588220 NCBI chrNW_004936621:117,785...140,917
Ensembl chrNW_004936621:117,785...140,926 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chrNW_004936474:158,376...282,310
Ensembl chrNW_004936474:157,590...282,342 		JBrowse link
G Muc1 mucin 1, cell surface associated ISO associated with Gallbladder Neoplasms;protein:altered localization:gallbladder
associated with Esophageal Neoplasms
associated with Common Bile Duct Neoplasms
associated with Carcinoma, Renal Cell;		 RGD PMID:10390012 PMID:11295067 PMID:16222735 PMID:21339746 RGD:2324649 RGD:2324860 RGD:7245968 RGD:7349383 NCBI chrNW_004936580:4,691,870...4,694,092 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO associated with chloangiocarcinoma;protein:increased expression:bile duct RGD PMID:16842244 RGD:2325168 NCBI chrNW_004936816:129,926...159,396 JBrowse link
G Ncam1 neural cell adhesion molecule 1 ISO RGD PMID:10086383 RGD:2326067 NCBI chrNW_004936612:1,262,557...1,556,281
Ensembl chrNW_004936612:1,262,544...1,556,016 		JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 ISO associated with Cervix Neoplasms; associated with Endometrial Neoplasms RGD PMID:8855975 RGD:2299062 NCBI chrNW_004936490:10,634,788...10,640,182
Ensembl chrNW_004936490:10,633,454...10,649,914 		JBrowse link
G Nos3 nitric oxide synthase 3 susceptibility ISO associated with Breast Neoplasms;DNA:polymorphisms:promoter, exon:-786T>C,p.E298D (human) RGD PMID:17262178 RGD:2292070 NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase ISO associated with breast cancer;DNA:missense mutation:cds:p.S326C (rs1052133) (human) RGD PMID:18977234 RGD:8657156 NCBI chrNW_004936602:3,411,106...3,418,826
Ensembl chrNW_004936602:3,413,282...3,418,831 		JBrowse link
G Pagr1 PAXIP1 associated glutamate rich protein 1 disease_progression ISO protein:decreased expression:esophagus (human) RGD PMID:33833989 RGD:153344568 NCBI chrNW_004936501:12,657,092...12,660,106
Ensembl chrNW_004936501:12,656,435...12,660,067 		JBrowse link
G Pdgfa platelet derived growth factor subunit A ISO associated with Breast Neoplasms;mRNA:increased expression:breast RGD PMID:8619189 RGD:2292155 NCBI chrNW_004936754:808,894...828,554
Ensembl chrNW_004936754:808,213...828,613 		JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO associated with Breast Neoplasms;mRNA:increased expression:lymph node RGD PMID:17674348 RGD:2292173 NCBI chrNW_004936492:2,353,840...2,368,573
Ensembl chrNW_004936492:2,353,841...2,368,573 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 ISO associated with non-small cell lung carcinoma;mRNA:increased expression:blood serum RGD PMID:25064732 RGD:13503320 NCBI chrNW_004936694:1,444,819...1,487,628
Ensembl chrNW_004936694:1,444,880...1,488,265
Ensembl chrNW_004936694:1,444,880...1,488,265 		JBrowse link
G Pdpn podoplanin ISO associated with Breast Neoplasms
associated with Cervix Neoplasms		 RGD PMID:16528371 PMID:18165897 RGD:2292231 RGD:2292237 NCBI chrNW_004936474:1,751,159...1,779,011
Ensembl chrNW_004936474:1,750,944...1,781,156 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 ISO associated with Breast Neoplasms
associated with Cervix Neoplasms		 RGD PMID:16243812 PMID:18191186 RGD:2302867 RGD:2302868 NCBI chrNW_004936668:2,316,661...2,323,015 JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO associated with Colorectal Neoplasms RGD PMID:25550888 RGD:13432030 NCBI chrNW_004936566:3,924,013...3,951,052
Ensembl chrNW_004936566:3,923,934...3,951,073 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta ISO associated with Colorectal Neoplasms RGD PMID:25550888 RGD:13432030 NCBI chrNW_004936540:907,118...1,041,814
Ensembl chrNW_004936540:907,112...1,041,848 		JBrowse link
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase type 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:34755307 NCBI chrNW_004936580:1,399,492...1,448,398
Ensembl chrNW_004936580:1,399,954...1,446,769 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 ISO associated with Seminoma; associated with Carcinoma, Embryonal RGD PMID:15386301 RGD:2292442 NCBI chrNW_004936837:827,568...838,933 JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO associated with Cholangiocarcinoma;protein:increased expression:bile duct epithelium RGD PMID:20021832 RGD:2317459 NCBI chrNW_004936602:1,230,907...1,368,588
Ensembl chrNW_004936602:1,230,907...1,304,743 		JBrowse link
G Prex1 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 ISO associated with Prostatic Neoplasms RGD PMID:19305425 RGD:2314605 NCBI chrNW_004936514:5,291,473...5,443,999
Ensembl chrNW_004936514:5,368,629...5,444,003 		JBrowse link
G Pten phosphatase and tensin homolog ISO associated with Prostatic Neoplasms;protein:decreased expression:prostate
associated with Breast Neoplasms		 RGD PMID:17163422 PMID:17919877 RGD:2292499 RGD:2292507 NCBI chrNW_004936735:1,252,414...1,338,318
Ensembl chrNW_004936735:1,252,414...1,338,323 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO associated with Biliary Tract Neoplasms
associated with carcinoma, non-small-cell lung; DNA:SNP: :929G>C(human)
associated with Breast Neoplasms		 RGD PMID:18159174 PMID:18353210 PMID:20016751 RGD:2300128 RGD:2317165 RGD:5135471 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO associated with lung squamous cell carcinoma; protein:increased tyrosine phosphorylation:lymph node RGD PMID:23906871 RGD:152176664 NCBI chrNW_004936470:10,379,855...10,578,531
Ensembl chrNW_004936470:10,379,872...10,578,543 		JBrowse link
G Ptpn13 protein tyrosine phosphatase non-receptor type 13 ISO associated with lung squamous cell carcinoma; protein:decreased expression:lymph node RGD PMID:23906871 RGD:152176664 NCBI chrNW_004936920:313,762...510,334
Ensembl chrNW_004936920:313,814...510,001 		JBrowse link
G Ramp2 receptor activity modifying protein 2 disease_progression ISO associated with colorectal cancer; protein:increased expression:lymph node (human) RGD PMID:23634287 RGD:151708733 NCBI chrNW_004936490:17,479,899...17,481,788
Ensembl chrNW_004936490:17,479,650...17,482,716 		JBrowse link
G Ramp3 receptor activity modifying protein 3 ISO associated with colorectal cancer; protein:increased expression:lymph node (human) RGD PMID:23634287 RGD:151708733 NCBI chrNW_004936478:19,977,618...20,001,366
Ensembl chrNW_004936478:19,977,539...20,004,838 		JBrowse link
G Rassf2 Ras association domain family member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17013896 NCBI chrNW_004936485:13,997,688...14,042,712
Ensembl chrNW_004936485:13,997,652...14,042,578 		JBrowse link
G Rbm10 RNA binding motif protein 10 ISO associated with lung adenocarcinoma;DNA:missense mutation:exon:p.R241C (c.763C>T) (human) RGD PMID:30405763 RGD:151356993 NCBI chrNW_004936502:12,923,890...12,952,179
Ensembl chrNW_004936502:12,925,910...12,955,470 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO associated with Prostatic Neoplasms;protein:altered localization:nucleus, prostate gland RGD PMID:17020979 RGD:2298757 NCBI chrNW_004936599:3,800,142...3,810,583
Ensembl chrNW_004936599:3,801,636...3,809,813 		JBrowse link
G Ret ret proto-oncogene ISO associated with Pancreatic Neoplasms RGD PMID:18652760 RGD:2324925 NCBI chrNW_004936617:2,927,185...2,980,594
Ensembl chrNW_004936617:2,927,155...2,980,602 		JBrowse link
G Rhoa ras homolog family member A ISO associated with Bladder Neoplasms;protein:increased expression:lymph node
associated with colorectal cancer		 RGD PMID:12855641 PMID:17597401 RGD:13432052 RGD:2298872 NCBI chrNW_004936529:1,000,050...1,045,655
Ensembl chrNW_004936529:999,935...1,045,681 		JBrowse link
G Rictor RPTOR independent companion of MTOR complex 2 ISO associated with breast ductal carcinoma; protein:increased expression:breast tumor, lymph node (human) RGD PMID:20978191 RGD:152995469 NCBI chrNW_004936518:3,198,312...3,314,393
Ensembl chrNW_004936518:3,198,337...3,310,000 		JBrowse link
G Sfn stratifin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chrNW_004936474:11,274,927...11,279,427
Ensembl chrNW_004936474:11,246,534...11,279,433 		JBrowse link
G Skp2 S-phase kinase associated protein 2 ISO associated with Endometrial Neoplasms;protein:increased expression:endometrium RGD PMID:16080017 RGD:2315043 NCBI chrNW_004936518:5,635,856...5,664,057
Ensembl chrNW_004936518:5,637,331...5,664,778 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 severity ISO associated with gastric adenocarcinoma;protein:increased expression: :
associated with stomach carcinoma		 RGD PMID:21501294 PMID:25908107 RGD:11052781 RGD:151361203 NCBI chrNW_004936641:1,513,110...1,538,955 JBrowse link
G Smad4 SMAD family member 4 ISO associated with Breast Neoplasms RGD PMID:11809701 RGD:2300007 NCBI chrNW_004936497:12,242,869...12,278,012
Ensembl chrNW_004936497:12,249,140...12,278,123 		JBrowse link
G Smo smoothened, frizzled class receptor ISO associated with colorectal cancer RGD PMID:30784110 RGD:150520177 NCBI chrNW_004936579:5,893,064...5,917,021
Ensembl chrNW_004936579:5,892,542...5,917,281 		JBrowse link
G Sncg synuclein gamma ISO RGD PMID:15221989 RGD:6478801 NCBI chrNW_004936804:16,869...21,684
Ensembl chrNW_004936804:16,614...21,969 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 ISO associated with Prostatic Neoplasms RGD PMID:16707422 RGD:2298925 NCBI chrNW_004936507:10,013,982...10,015,480
Ensembl chrNW_004936507:10,012,101...10,014,456 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO associated with Breast Neoplasms RGD PMID:18097573 RGD:2298901 NCBI chrNW_004936594:2,932,297...2,935,358
Ensembl chrNW_004936594:2,933,747...2,934,451 		JBrowse link
G Sod2 superoxide dismutase 2 disease_progression ISO associated with tongue neoplasms;
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:10853026 PMID:19381893 PMID:20618948 RGD:8547519 NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781 		JBrowse link
G Sox2 SRY-box transcription factor 2 disease_progression ISO associated with Breast Neoplasms RGD PMID:24382260 RGD:8661670 NCBI chrNW_004936566:1,630,698...1,632,607
Ensembl chrNW_004936566:1,631,822...1,632,613 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO associated with colon adenocarcinoma, RGD PMID:21282564 RGD:150520218 NCBI chrNW_004936561:3,826,802...3,844,406
Ensembl chrNW_004936561:3,825,787...3,844,483 		JBrowse link
G St14 ST14 transmembrane serine protease matriptase ISO associated with Endometrial Neoplasms RGD PMID:19443387 RGD:2315087 NCBI chrNW_004936572:2,137,820...2,182,674
Ensembl chrNW_004936572:2,137,332...2,182,742 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21549414 NCBI chrNW_004936490:17,119,189...17,178,402
Ensembl chrNW_004936490:17,117,290...17,178,402 		JBrowse link
G Stk11 serine/threonine kinase 11 ISO associated with Breast Neoplasms;protein:decreased expression RGD PMID:12114407 RGD:2291948 NCBI chrNW_004936588:579,816...601,033
Ensembl chrNW_004936588:579,816...603,654 		JBrowse link
G Tert telomerase reverse transcriptase disease_progression ISO associated with lung non-small cell carcinoma; RGD PMID:11679180 RGD:152977755 NCBI chrNW_004936815:468,987...492,666
Ensembl chrNW_004936815:469,020...491,697 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ISO associated with Endometrial Neoplasms;protein:increased expression:endometrium RGD PMID:12487935 RGD:2298523 NCBI chrNW_004936502:13,345,936...13,350,170
Ensembl chrNW_004936502:13,345,832...13,350,248 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 ISO associated with Breast Neoplasms;mRNA:increased expression:breast RGD PMID:12828172 RGD:2290437 NCBI chrNW_004936492:6,996,627...7,046,137
Ensembl chrNW_004936492:6,996,613...7,046,190 		JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 ISO associated with Breast Neoplasms;mRNA:increased expression:breast RGD PMID:12828172 RGD:2290437 NCBI chrNW_004936602:1,488,993...1,496,108
Ensembl chrNW_004936602:1,489,545...1,495,478 		JBrowse link
G Tlr4 toll like receptor 4 ISO associated with Carcinoma, Ductal, Breast; RGD PMID:23338716 RGD:7794684 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
G Tp53 tumor protein p53 ISO associated with Carcinoma, Squamous Cell;
associated with Breast Neoplasms;DNA:missense mutation, duplication:cds, intron:p.R72P
associated with Penile Neoplasms		 RGD PMID:18059331 PMID:18230179 PMID:18268397 RGD:2290533 RGD:2290534 RGD:8547790 NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chrNW_004936471:6,589,395...6,668,242
Ensembl chrNW_004936471:6,589,564...6,668,305 		JBrowse link
G Trmt11 tRNA methyltransferase 11 homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chrNW_004936639:3,442,026...3,494,303
Ensembl chrNW_004936639:3,440,703...3,494,362 		JBrowse link
G Tsc2 TSC complex subunit 2 ISO associated with Breast Neoplasms RGD PMID:15951164 RGD:11568707 NCBI chrNW_004936694:1,958,152...1,993,373
Ensembl chrNW_004936694:1,958,154...1,993,363 		JBrowse link
G Tshr thyroid stimulating hormone receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9062474 NCBI chrNW_004936488:9,428,053...9,560,856
Ensembl chrNW_004936488:9,427,962...9,560,685 		JBrowse link
G Ttr transthyretin ISO associated with colorectal cancer;protein:decreased expresion:blood serum (human) RGD PMID:21074777 RGD:151665155 NCBI chrNW_004936682:1,628,489...1,635,495
Ensembl chrNW_004936682:1,628,341...1,635,566 		JBrowse link
G Tymp thymidine phosphorylase ISO associated with Breast Neoplasms
associated with Cholangiocarcinoma		 RGD PMID:10685502 PMID:11927969 RGD:2293725 RGD:2325027 NCBI chrNW_004936629:315,609...320,356
Ensembl chrNW_004936629:315,610...319,076 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO associated with Breast neoplasms;
associated with Cervix Neoplasms		 RGD PMID:17597103 PMID:19783962 RGD:2315454 RGD:7421574 NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673 		JBrowse link
G Vegfc vascular endothelial growth factor C exacerbates
disease_progression		 ISO associated with Lymphatic Metastasis;
associated with pancreatic adenocarcinoma;protein:increased expression:pancreas (human)
associated with thyroid diseases;mRNA:increased expression:thyroid gland:
associated with Prostatic Neoplasms
associated with Breast Neoplasms
associated with Carcinoma, Transitional Cell;protein:increased expression:urinary bladder
associated with Cervix Neoplasms		 RGD PMID:12203051 PMID:15289890 PMID:17034609 PMID:18061373 PMID:19589137 More... RGD:155630642 RGD:2315469 RGD:2315474 RGD:2315475 RGD:2315484 RGD:7483611 RGD:7488946 NCBI chrNW_004936516:7,217,543...7,332,531
Ensembl chrNW_004936516:7,217,543...7,332,559 		JBrowse link
G Vegfd vascular endothelial growth factor D ISO associated with Cervix Neoplasms
associated with Breast Neoplasms		 RGD PMID:17951197 PMID:19589137 RGD:2315475 RGD:2315480 NCBI chrNW_004936470:4,761,827...4,794,751
Ensembl chrNW_004936470:4,762,332...4,793,938 		JBrowse link
G Wrap53 WD repeat containing antisense to TP53 ISO associated with lung non-small cell carcinoma;
associated with esophagus squamous cell carcinoma;		 RGD PMID:24626331 PMID:31281482 RGD:21081513 RGD:21081532 NCBI chrNW_004936595:936,184...952,784
Ensembl chrNW_004936595:936,487...952,791 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14569
    disease of anatomical entity 14271
      immune system disease 4261
        lymphatic system disease 1586
          Lymphatic Metastasis 145
Path 2
Term Annotations click to browse term
  disease 14569
    disease of anatomical entity 14271
      Immune & Inflammatory Diseases 4892
        immune system disease 4261
          lymphatic system disease 1586
            Lymphatic Metastasis 145
paths to the root