RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Lymphatic Metastasis
Accession: DOID:9000081
browse the term
Definition: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Synonyms: exact_synonym: Lymphatic Metastases
narrow_synonym: lymph node metastatic carcinoma
primary_id: MESH:D008207 ; RDO:0006041
xref: EFO:0004906 ; EFO:1001364
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ABCA13
ATP binding cassette subfamily A member 13
susceptibility
IAGP
DNA:amplification:cds: (human, male)
RGD
PMID:27366209
RGD:152995256
NCBI chr 7:48,171,458...48,647,497
Ensembl chr 7:48,171,458...48,647,497
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ADAM28
ADAM metallopeptidase domain 28
IDA
associated with breast cancer;DNA:hypermethylation:
RGD
PMID:25620615
RGD:153298970
NCBI chr 8:24,294,069...24,359,014
Ensembl chr 8:24,294,069...24,359,014
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ADGRB1
adhesion G protein-coupled receptor B1
disease_progression
IEP
associated with stomach cancer;
RGD
PMID:11172604
RGD:13831357
NCBI chr 8:142,449,649...142,545,007
Ensembl chr 8:142,449,430...142,545,009
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AGAP2-AS1
AGAP2 antisense RNA 1
IEP
associated with non-small cell lung carcinoma;
RGD
PMID:28617550
RGD:13838847
NCBI chr12:57,726,240...57,728,356
Ensembl chr12:57,726,271...57,728,356
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AICDA
activation induced cytidine deaminase
IEP
associated with stomach cancer;protein:increased expression:stomach (human)
RGD
PMID:21538122
RGD:127285638
NCBI chr12:8,602,170...8,612,859
Ensembl chr12:8,602,155...8,613,242
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ANGPTL4
angiopoietin like 4
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:17130448
NCBI chr19:8,364,155...8,374,370
Ensembl chr19:8,363,289...8,374,370
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ANXA1
annexin A1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:19381893
NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393
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AQP3
aquaporin 3 (Gill blood group)
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:21401805
NCBI chr 9:33,441,160...33,447,593
Ensembl chr 9:33,441,156...33,447,596
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ARHGAP5
Rho GTPase activating protein 5
IEP
associated with nasopharynx carcinoma;mRNA, protein:increased expression: epithelium of nasopharynx
RGD
PMID:25961434
RGD:11056278
NCBI chr14:32,077,304...32,159,728
Ensembl chr14:32,076,114...32,159,728
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ASXL1
ASXL transcriptional regulator 1
IEP
associated with colorectal cancer
RGD
PMID:32317519
RGD:126779580
NCBI chr20:32,358,331...32,439,319
Ensembl chr20:32,358,330...32,439,319
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AXL
AXL receptor tyrosine kinase
IEP
associated Pancreatic Neoplasms
RGD
PMID:19252414
RGD:2325833
NCBI chr19:41,219,223...41,261,766
Ensembl chr19:41,219,223...41,261,766
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BAG1
BAG cochaperone 1
disease_progression
IEP
associated with Breast Neoplasms:protein:increased expression:breast
RGD
PMID:18430249
RGD:2292908
NCBI chr 9:33,252,471...33,264,708
Ensembl chr 9:33,247,820...33,264,720
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BAMBI
BMP and activin membrane bound inhibitor
IEP
associated with stomach cancer; protein:increased expression: :
RGD
PMID:24752577
RGD:14390158
NCBI chr10:28,677,521...28,682,932
Ensembl chr10:28,677,510...28,682,932
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BARHL2
BarH like homeobox 2
IEP
associated with oral squamous cell carcinoma; mRNA:decreased expression:mouth mucosa
RGD
PMID:27542258
RGD:14390167
NCBI chr 1:90,711,539...90,717,302
Ensembl chr 1:90,711,539...90,717,302
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BCL2
BCL2 apoptosis regulator
IEP
associated with Breast Neoplasms;protein:increased expression:lymph node
RGD
PMID:18217456
RGD:2293013
NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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BIK
BCL2 interacting killer
IAGP
associated with cholangiocarcinoma;DNA:CNV::
RGD
PMID:16865775
RGD:14394820
NCBI chr22:43,110,750...43,129,712
Ensembl chr22:43,110,750...43,129,712
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BIRC5
baculoviral IAP repeat containing 5
disease_progression
IEP
associated with Cervix Neoplasms;mRNA:splice variant associated with Breast Neoplasms
RGD
PMID:17877643 PMID:17285241
RGD:2293098 , RGD:2293103
NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
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BRAF
B-Raf proto-oncogene, serine/threonine kinase
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:29426936
NCBI chr 7:140,713,328...140,924,929
Ensembl chr 7:140,719,327...140,924,929
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BRD7
bromodomain containing 7
severity
IEP
protein:increased expression:lung:
RGD
PMID:22008115
RGD:9586442
NCBI chr16:50,315,957...50,368,988
Ensembl chr16:50,313,487...50,368,988
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BSG
basigin (Ok blood group)
disease_progression
IEP
associated with Breast Neoplasms
RGD
PMID:16004819
RGD:2289055
NCBI chr19:571,283...583,493
Ensembl chr19:571,277...583,494
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BTK
Bruton tyrosine kinase
disease_progression
IEP
associated with lung adenocarcinoma;protein:increased expression:lung (human)
RGD
PMID:31200752
RGD:151347847
NCBI chr X:101,349,450...101,390,796
Ensembl chr X:101,349,338...101,390,796
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CA9
carbonic anhydrase 9
IEP
associated with Cervix Neoplasms
RGD
PMID:17233814
RGD:2293196
NCBI chr 9:35,673,928...35,681,159
Ensembl chr 9:35,673,928...35,681,159
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CAB39
calcium binding protein 39
IEP
associated with pancreatic cancer;RNA:increased expression:pancreas
RGD
PMID:28197410
RGD:14398834
NCBI chr 2:230,712,842...230,821,075
Ensembl chr 2:230,712,842...230,821,075
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CASP9
caspase 9
IAGP
associated with Carcinoma, Non-Small-Cell Lung;DNA:SNP:exon:rs1052576 (human)
RGD
PMID:17285546
RGD:13434907
NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
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CAV1
caveolin 1
disease_progression
IEP
associated with Melanoma
RGD
PMID:22134245
RGD:8661767
NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179
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CBL
Cbl proto-oncogene
IEP
associated with stomach carcinoma;protein:increased expression:stomach
RGD
PMID:31611438
RGD:126925223
NCBI chr11:119,206,339...119,308,149
Ensembl chr11:119,206,298...119,313,926
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CBLB
Cbl proto-oncogene B
IEP
associated with stomach carcinoma;
RGD
PMID:20038312
RGD:150540338
NCBI chr 3:105,655,461...105,869,449
Ensembl chr 3:105,655,461...105,869,552
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CCND2
cyclin D2
IEP
associated with colorectal cancer;protein:increased expression:colorectum
RGD
PMID:19508551
RGD:151665111
NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353
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CCNE1
cyclin E1
IEP
associated with Carcinoma, Transitional Cell;protein:decreased expression
RGD
PMID:16949911
RGD:2289266
NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
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CCNH
cyclin H
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:30705370
NCBI chr 5:87,311,471...87,412,930
Ensembl chr 5:87,318,416...87,413,029
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CCR5
C-C motif chemokine receptor 5
IEP
associated with Breast Neoplasms;mRNA:increased expression:lymph node
RGD
PMID:24301790
RGD:8551816
NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,946...46,376,206
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CD274
CD274 molecule
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:16530813
NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566
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CD40
CD40 molecule
IAGP
associated with breast cancer;DNA:snps:5' utr, intron:c.-1T>C, c.51+914T>G (rs1883832, rs4810485) (human)
RGD
PMID:21912605
RGD:8547780
NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863
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CD44
CD44 molecule (IN blood group)
IDA
associated with Breast Neoplasms, Colorectal Neoplasms, Stomach Neoplasms;mRNA, protein:splice variant, increased expression:breast, large intestine, stomach
RGD
PMID:16425351
RGD:2289356
NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402
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CDH1
cadherin 1
IEP
associated with Cervix Neoplasms associated with Breast Neoplasms
RGD
PMID:18097581 PMID:17649807
RGD:2296046 , RGD:2289498
NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
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CDKN1A
cyclin dependent kinase inhibitor 1A
IEP
associated with Eyelid Neoplasms; associated with Oral Squamous Cell Carcinoma;
RGD
PMID:19628749 PMID:15817070
RGD:8661799 , RGD:8662374
NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
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CDKN1B
cyclin dependent kinase inhibitor 1B
IEP
associated with Breast Neoplasms associated with non-small cell lung carcinoma
RGD
PMID:12015771 PMID:28601655
RGD:2293607 , RGD:13673921
NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369
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CDKN2A
cyclin dependent kinase inhibitor 2A
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:29426936
NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301
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CLDN1
claudin 1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:33665778
NCBI chr 3:190,305,707...190,322,446
Ensembl chr 3:190,305,707...190,322,446
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CLPTM1L
CLPTM1 like
IEP
associated with esophagus squamous cell carcinoma; mRNA:increased expression:esophagus
RGD
PMID:25480402
RGD:150530497
NCBI chr 5:1,317,752...1,345,099
Ensembl chr 5:1,317,752...1,345,099
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CLU
clusterin
IAGP
associated with breast cancer;DNA:snp:promoter:g.27611345C>G (rs9331888) (human)
RGD
PMID:22037783
RGD:8963167
NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700
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COMT
catechol-O-methyltransferase
IAGP
associated with breast cancer;DNA:missense mutation:cds:p.V108/158M (human)
RGD
PMID:10755383
RGD:8662330
NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975
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CRP
C-reactive protein
susceptibility
IAGP
associated with Breast Neoplasm; DNA:polymorphism: :1846C>T(rs1205)(human)
RGD
PMID:24633920
RGD:9580226
NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
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CSF1R
colony stimulating factor 1 receptor
IEP
associated with Breast Neoplasms
RGD
PMID:14734466
RGD:2293711
NCBI chr 5:150,053,295...150,113,365
Ensembl chr 5:150,053,291...150,113,372
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CTLA4
cytotoxic T-lymphocyte associated protein 4
ISO
associated with Prostatic Neoplasms
RGD
PMID:10611340
RGD:4891523
NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,853,888...203,873,965
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CTNNA1
catenin alpha 1
IEP
associated with Breast Neoplasms
RGD
PMID:12047765
RGD:2289795
NCBI chr 5:138,753,425...138,935,034
Ensembl chr 5:138,610,967...138,935,034
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CTNNB1
catenin beta 1
IEP
associated with Breast Neoplasms;protein:decreased expression
RGD
PMID:17908479
RGD:2289813
NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
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CXCL12
C-X-C motif chemokine ligand 12
disease_progression
IEP
associated with stomach cancer;mRNA:increased expression:stomach (human)
RGD
PMID:21633638
RGD:152023624
NCBI chr10:44,370,165...44,385,097
Ensembl chr10:44,370,165...44,386,493
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CXCR4
C-X-C motif chemokine receptor 4
IEP
associated with nasopharynx carcinoma; protein:increased expression:lymph node (human)
RGD
PMID:16000558
RGD:151893515
NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177
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CYCS
cytochrome c, somatic
IDA
associated with non-small cell lung carcinoma; protein:decreased expression:serum
RGD
PMID:25578497
RGD:13792769
NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
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DDR1
discoidin domain receptor tyrosine kinase 1
severity
IEP
mRNA, protein:increased expression:mouth (human) mRNA:increased expression:kidney, lymph nodes (human)
RGD
PMID:31253192 PMID:27020590
RGD:151347620 , RGD:151347863
NCBI chr 6:30,880,970...30,900,156
Ensembl chr 6:30,876,421...30,900,156
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DDR2
discoidin domain receptor tyrosine kinase 2
disease_progression
IDA
associated with oral squamous cell carcinoma
RGD
PMID:29945346
RGD:150429700
NCBI chr 1:162,630,863...162,787,405
Ensembl chr 1:162,631,373...162,787,405
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DNMT3B
DNA methyltransferase 3 beta
IEP
associated with Carcinoma, Pancreatic Ductal;
RGD
PMID:22919364
RGD:9589121
NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,359
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EBAG9
estrogen receptor binding site associated antigen 9
IEP
associated with Breast Neoplasms;protein:increased expression:breast associated with Prostatic Neoplasm;protein:increased expression:prostate gland, lymph node
RGD
PMID:12054692 PMID:12845666 PMID:17187007
RGD:2298489 , RGD:2289856 , RGD:2289847
NCBI chr 8:109,539,702...109,565,996
Ensembl chr 8:109,539,711...109,570,072
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EGFR
epidermal growth factor receptor
treatment
ISO
associated with Squamous Cell Carcinoma of the Tongue
RGD
PMID:19380367
RGD:8551769
NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
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EHMT2
euchromatic histone lysine methyltransferase 2
IEP
associated with Melanoma; associated with Esophageal Squamous Cell Carcinoma;
RGD
PMID:24658378 PMID:24805087
RGD:9590069 , RGD:9590071
NCBI chr 6:31,879,759...31,897,698
Ensembl chr 6:31,879,759...31,897,698
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EPHA2
EPH receptor A2
IEP
protein:increased expression:esophagus (human)
RGD
PMID:33833989
RGD:153344568
NCBI chr 1:16,124,337...16,156,069
Ensembl chr 1:16,124,337...16,156,069
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ERBB2
erb-b2 receptor tyrosine kinase 2
disease_progression
IEP EXP
associated with Carcinoma, Transitional Cell;protein:increased expression:urinary bladder associated with Breast Neoplasms;DNA, protein:polymorphism, increased expression:serum:p.I655V CTD Direct Evidence: marker/mechanism associated with lung adenocarcinoma; protein:increased expression:lung (human)
CTD RGD
PMID:21532492 PMID:18097576 PMID:18237248 PMID:21966491
RGD:2289926 , RGD:2289925 , RGD:153344600
NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426
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ERBB3
erb-b2 receptor tyrosine kinase 3
IEP
associated with Prostatic Neoplasms;protein:increased expression, altered localization:lymph node, nucleus associated with head and neck squamous cell carcinoma
RGD
PMID:17634423 PMID:20604875
RGD:2289944 , RGD:126790467
NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505
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ERBB4
erb-b2 receptor tyrosine kinase 4
severity disease_progression
IEP
associated with oral squamous cell carcinoma associated with colorectal adenocarcinoma associated with lung non-small cell carcinoma
RGD
PMID:27444519 PMID:16507107 PMID:21324275
RGD:126781762 , RGD:126781766 , RGD:126790471
NCBI chr 2:211,375,717...212,538,802
Ensembl chr 2:211,375,717...212,538,841
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FAS
Fas cell surface death receptor
susceptibility
IAGP
associated with Cervix Neoplasms;DNA:polymorphism:promoter:-1377G>A
RGD
PMID:18068525
RGD:2298509
NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
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FGF1
fibroblast growth factor 1
IEP
associated with Cervix Neoplasms;mRNA:increased expression:lymph node
RGD
PMID:17242701
RGD:2290286
NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070
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FGFR2
fibroblast growth factor receptor 2
IAGP
associated with breast cancer;DNA:snp:intron:c.109+7033T>A (rs1219648) (human)
RGD
PMID:20640597
RGD:7394846
NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458
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FLT3
fms related receptor tyrosine kinase 3
disease_progression
ISO
associated with Prostatic Neoplasms
RGD
PMID:14566827
RGD:2302210
NCBI chr13:28,003,274...28,100,576
Ensembl chr13:28,003,274...28,100,592
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FOXA1
forkhead box A1
IEP
associated with lung non-small cell carcinoma; mRNA:increased expression: :
RGD
PMID:29115441
RGD:151665751
NCBI chr14:37,589,552...37,595,249
Ensembl chr14:37,589,552...37,596,059
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FOXP1
forkhead box P1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:25485836
NCBI chr 3:70,954,708...71,583,978
Ensembl chr 3:70,954,693...71,583,978
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GPX3
glutathione peroxidase 3
IDA
associated with stomach carcinoma; DNA:hypermethylation:promoter
RGD
PMID:23071548
RGD:151665353
NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988
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GRIK2
glutamate ionotropic receptor kainate type subunit 2
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:30705370
NCBI chr 6:101,393,708...102,070,083
Ensembl chr 6:100,962,701...102,081,622
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HMGB1
high mobility group box 1
ISO
associated with Adenocarcinoma, Colon
RGD
PMID:20616616
RGD:10402080
NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
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ICAM1
intercellular adhesion molecule 1
IEP
associated with Breast Neoplasms
RGD
PMID:21590495
RGD:8547712
NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
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IER2
immediate early response 2
ISO
RGD
PMID:22120713
RGD:153323322
NCBI chr19:13,150,411...13,154,911
Ensembl chr19:13,150,411...13,154,911
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IL13
interleukin 13
IEP
associated with Melanoma, Cutaneous Malignant;mRNA:increased expression:lymph node
RGD
PMID:17545514
RGD:8549587
NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
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IL18
interleukin 18
IEP
associated with Breast Neoplasms;protein:increased expression:serum
RGD
PMID:12902898
RGD:8655867
NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096
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ING4
inhibitor of growth family member 4
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:27806345
NCBI chr12:6,650,301...6,663,119
Ensembl chr12:6,650,301...6,663,142
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IQSEC1
IQ motif and Sec7 domain ArfGEF 1
disease_progression
IEP
associated with lung adenocarcinoma; protein:increased expression:lung (human)
RGD
PMID:21966491
RGD:153344600
NCBI chr 3:12,897,043...13,283,257
Ensembl chr 3:12,897,043...13,283,281
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ITGB1
integrin subunit beta 1
IEP
associated with non-small cell lung carcinoma,
RGD
PMID:28537888
RGD:13792830
NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792
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KCNJ12
potassium inwardly rectifying channel subfamily J member 12
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:34755307
NCBI chr17:21,376,357...21,419,870
Ensembl chr17:21,376,357...21,419,870
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KDR
kinase insert domain receptor
treatment
ISO
associated with Squamous Cell Carcinoma of the Tongue
RGD
PMID:19380367
RGD:8551769
NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
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KISS1
KiSS-1 metastasis suppressor
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:21383688
NCBI chr 1:204,190,341...204,196,491
Ensembl chr 1:204,190,341...204,196,491
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KLF7
KLF transcription factor 7
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:37734194
NCBI chr 2:207,074,137...207,173,851
Ensembl chr 2:207,074,137...207,173,856
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KMT2D
lysine methyltransferase 2D
IEP
associated with stomach cancer
RGD
PMID:30177394
RGD:150521710
NCBI chr12:49,018,978...49,060,794
Ensembl chr12:49,018,975...49,060,794
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LAMC2
laminin subunit gamma 2
IEP
associated with lung squamous cell carcinoma;
RGD
PMID:23124251
RGD:13793371
NCBI chr 1:183,186,264...183,258,968
Ensembl chr 1:183,186,238...183,245,127
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LRRC59
leucine rich repeat containing 59
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:30705370
NCBI chr17:50,381,238...50,397,523
Ensembl chr17:50,375,059...50,397,523
G
MACIR
macrophage immunometabolism regulator
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:30705370
NCBI chr 5:103,258,374...103,278,660
Ensembl chr 5:103,258,763...103,278,660
G
MET
MET proto-oncogene, receptor tyrosine kinase
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:29426936
NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377
G
MIR125A
microRNA 125a
IEP
associated with stomach cancer;
RGD
PMID:22322911
RGD:21408544
NCBI chr19:51,693,254...51,693,339
Ensembl chr19:51,693,254...51,693,339
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MIR152
microRNA 152
IEP
associated with breast cancer
RGD
PMID:22935141
RGD:19165152
NCBI chr17:48,037,161...48,037,247
Ensembl chr17:48,037,161...48,037,247
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MIR155
microRNA 155
disease_progression
IEP
associated with colon cancer
RGD
PMID:26885061 PMID:27856635 PMID:29893326
RGD:21079444 , RGD:21079446 , RGD:21409756
NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044
G
MIR187
microRNA 187
IEP
associated with oral squamous cell carcinoma; RNA:increased expression:plasma
RGD
PMID:27542258
RGD:14390167
NCBI chr18:35,904,818...35,904,926
Ensembl chr18:35,904,818...35,904,926
G
MIR224
microRNA 224
IEP
associated with colorectal cancer; mRNA:decreased expression:colorectal mucosa:
RGD
PMID:25919696
RGD:14398749
NCBI chr X:151,958,578...151,958,658
Ensembl chr X:151,958,578...151,958,658
G
MIR30A
microRNA 30a
IEP
associated with Colorectal Neoplasms
RGD
PMID:23486085
RGD:13432035
NCBI chr 6:71,403,551...71,403,621
Ensembl chr 6:71,403,551...71,403,621
G
MIR335
microRNA 335
IEP
associated with stomach cancer; RNA:decreased expression:stomach
RGD
PMID:21822301
RGD:14394425
NCBI chr 7:130,496,111...130,496,204
Ensembl chr 7:130,496,111...130,496,204
G
MIR432
microRNA 432
disease_progression
IEP
mRNA:decreased expression:colon (human)
RGD
PMID:33717244
RGD:152999433
NCBI chr14:100,884,483...100,884,576
Ensembl chr14:100,884,483...100,884,576
G
MMP2
matrix metallopeptidase 2
disease_progression
IEP
associated with Tongue Neoplasms associated with Carcinoma, Ductal, Breast
RGD
PMID:23107277 PMID:23280016
RGD:8547824 , RGD:8655998
NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
G
MMP3
matrix metallopeptidase 3
IAGP
associated with breast cancer;DNA:deletion:promoter:-1170_-1172delA (human)
RGD
PMID:15161710
RGD:8662937
NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
G
MMP9
matrix metallopeptidase 9
disease_progression
IEP
associated with Carcinoma, Non-Small-Cell Lung;protein:increased expression:serum associated with Endometrial Neoplasms;protein:increased expression:endometrium associated with Tongue Neoplasms
RGD
PMID:20704821 PMID:12487935 PMID:23107277
RGD:5129215 , RGD:2298523 , RGD:8547824
NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
G
MSH2
mutS homolog 2
IEP
associated with laryngeal squamous cell carcinoma
RGD
PMID:24459922
RGD:126848797
NCBI chr 2:47,403,067...47,709,830
Ensembl chr 2:47,403,067...47,663,146
G
MSLN
mesothelin
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:22644300
NCBI chr16:760,734...768,865
Ensembl chr16:760,734...768,865
G
MT1A
metallothionein 1A
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:17418620
NCBI chr16:56,638,666...56,640,087
Ensembl chr16:56,638,666...56,640,087
G
MTA1
metastasis associated 1
IEP
associated with Carcinoma, Non-Small-Cell Lung;mRNA:increased expression:lung
RGD
PMID:11804687
RGD:9588220
NCBI chr14:105,419,827...105,470,729
Ensembl chr14:105,419,820...105,470,729
G
MTOR
mechanistic target of rapamycin kinase
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:30705370
NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556
G
MUC1
mucin 1, cell surface associated
IEP
associated with Common Bile Duct Neoplasms associated with Gallbladder Neoplasms;protein:altered localization:gallbladder associated with Carcinoma, Renal Cell; associated with Esophageal Neoplasms
RGD
PMID:16222735 PMID:11295067 PMID:10390012 PMID:21339746
RGD:2324649 , RGD:2324860 , RGD:7245968 , RGD:7349383
NCBI chr 1:155,185,824...155,192,915
Ensembl chr 1:155,185,824...155,192,916
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MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
IEP
associated with chloangiocarcinoma;protein:increased expression:bile duct
RGD
PMID:16842244
RGD:2325168
NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138
G
NCAM1
neural cell adhesion molecule 1
ISO
RGD
PMID:10086383
RGD:2326067
NCBI chr11:112,961,420...113,278,436
Ensembl chr11:112,961,275...113,278,436
G
NME1
NME/NM23 nucleoside diphosphate kinase 1
IEP
associated with Cervix Neoplasms; associated with Endometrial Neoplasms associated with Breast Neoplasms
RGD
PMID:8855975 PMID:9036878 PMID:8102131
RGD:2299062 , RGD:2299061 , RGD:2299077
NCBI chr17:51,153,559...51,162,168
Ensembl chr17:51,153,559...51,162,428
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NME2
NME/NM23 nucleoside diphosphate kinase 2
IEP
associated with Cervix Neoplasms; associated with Endometrial Neoplasms
RGD
PMID:8855975
RGD:2299062
NCBI chr17:51,165,536...51,171,744
Ensembl chr17:51,165,435...51,171,744
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NOS3
nitric oxide synthase 3
susceptibility
IAGP
associated with Breast Neoplasms;DNA:polymorphisms:promoter, exon:-786T>C,p.E298D (human)
RGD
PMID:17262178
RGD:2292070
NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
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OGG1
8-oxoguanine DNA glycosylase
IAGP
associated with breast cancer;DNA:missense mutation:cds:p.S326C (rs1052133) (human)
RGD
PMID:18977234
RGD:8657156
NCBI chr 3:9,749,952...9,783,108
Ensembl chr 3:9,749,944...9,788,219
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PAGR1
PAXIP1 associated glutamate rich protein 1
disease_progression
IEP
protein:decreased expression:esophagus (human)
RGD
PMID:33833989
RGD:153344568
NCBI chr16:29,816,152...29,822,489
Ensembl chr16:29,816,152...29,822,489
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PDGFA
platelet derived growth factor subunit A
IEP
associated with Breast Neoplasms;mRNA:increased expression:breast
RGD
PMID:8619189
RGD:2292155
NCBI chr 7:497,258...520,700
Ensembl chr 7:497,258...520,296
G
PDGFB
platelet derived growth factor subunit B
IEP
associated with Breast Neoplasms;mRNA:increased expression:lymph node
RGD
PMID:17674348
RGD:2292173
NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982
G
PDPK1
3-phosphoinositide dependent protein kinase 1
IEP
associated with non-small cell lung carcinoma;mRNA:increased expression:blood serum
RGD
PMID:25064732
RGD:13503320
NCBI chr16:2,538,021...2,603,188
Ensembl chr16:2,537,979...2,603,188
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PDPN
podoplanin
IEP
associated with Cervix Neoplasms associated with Breast Neoplasms
RGD
PMID:16528371 PMID:18165897
RGD:2292237 , RGD:2292231
NCBI chr 1:13,583,757...13,617,957
Ensembl chr 1:13,583,465...13,617,957
G
PEBP1
phosphatidylethanolamine binding protein 1
IEP
associated with Breast Neoplasms associated with Cervix Neoplasms
RGD
PMID:16243812 PMID:18191186
RGD:2302868 , RGD:2302867
NCBI chr12:118,136,124...118,145,584
Ensembl chr12:118,136,124...118,145,584
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PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
IEP
associated with Colorectal Neoplasms
RGD
PMID:25550888
RGD:13432030
NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093
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PIK3CB
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
IEP
associated with Colorectal Neoplasms
RGD
PMID:25550888
RGD:13432030
NCBI chr 3:138,652,698...138,834,928
Ensembl chr 3:138,652,698...138,834,928
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PIP5K1A
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:34755307
NCBI chr 1:151,195,419...151,249,531
Ensembl chr 1:151,197,949...151,249,536
G
POU5F1
POU class 5 homeobox 1
IEP
associated with Seminoma; associated with Carcinoma, Embryonal
RGD
PMID:15386301
RGD:2292442
NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731
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PPARG
peroxisome proliferator activated receptor gamma
IEP
associated with Cholangiocarcinoma;protein:increased expression:bile duct epithelium
RGD
PMID:20021832
RGD:2317459
NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
G
PREX1
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
IMP
associated with Prostatic Neoplasms
RGD
PMID:19305425
RGD:2314605
NCBI chr20:48,624,252...48,888,185
Ensembl chr20:48,624,252...48,827,999
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PTEN
phosphatase and tensin homolog
IEP
associated with Prostatic Neoplasms;protein:decreased expression:prostate associated with Breast Neoplasms
RGD
PMID:17163422 PMID:17919877
RGD:2292507 , RGD:2292499
NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930
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PTGS2
prostaglandin-endoperoxide synthase 2
IEP IAGP
associated with Biliary Tract Neoplasms associated with Breast Neoplasms associated with carcinoma, non-small-cell lung; DNA:SNP: :929G>C(human)
RGD
PMID:18159174 PMID:18353210 PMID:20016751
RGD:2317165 , RGD:2300128 , RGD:5135471
NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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PTK2
protein tyrosine kinase 2
IEP
associated with lung squamous cell carcinoma; protein:increased tyrosine phosphorylation:lymph node
RGD
PMID:23906871
RGD:152176664
NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216
G
PTPN13
protein tyrosine phosphatase non-receptor type 13
IEP
associated with lung squamous cell carcinoma; protein:decreased expression:lymph node
RGD
PMID:23906871
RGD:152176664
NCBI chr 4:86,594,315...86,815,161
Ensembl chr 4:86,594,315...86,815,171
G
RAMP2
receptor activity modifying protein 2
disease_progression
HEP
associated with colorectal cancer; protein:increased expression:lymph node (human)
RGD
PMID:23634287
RGD:151708733
NCBI chr17:42,761,227...42,763,041
Ensembl chr17:42,758,447...42,763,041
G
RAMP3
receptor activity modifying protein 3
HEP
associated with colorectal cancer; protein:increased expression:lymph node (human)
RGD
PMID:23634287
RGD:151708733
NCBI chr 7:45,157,791...45,184,250
Ensembl chr 7:45,157,791...45,186,302
G
RASSF2
Ras association domain family member 2
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:17013896
NCBI chr20:4,780,023...4,823,608
Ensembl chr20:4,780,023...4,823,608
G
RBM10
RNA binding motif protein 10
IAGP
associated with lung adenocarcinoma;DNA:missense mutation:exon:p.R241C (c.763C>T) (human)
RGD
PMID:30405763
RGD:151356993
NCBI chr X:47,145,221...47,186,813
Ensembl chr X:47,145,221...47,186,813
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RELA
RELA proto-oncogene, NF-kB subunit
IEP
associated with Prostatic Neoplasms;protein:altered localization:nucleus, prostate gland
RGD
PMID:17020979
RGD:2298757
NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
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RET
ret proto-oncogene
IEP
associated with Pancreatic Neoplasms
RGD
PMID:18652760
RGD:2324925
NCBI chr10:43,077,069...43,130,351
Ensembl chr10:43,077,064...43,130,351
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RHOA
ras homolog family member A
IEP
associated with Bladder Neoplasms;protein:increased expression:lymph node associated with colorectal cancer
RGD
PMID:12855641 PMID:17597401
RGD:2298872 , RGD:13432052
NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998
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RICTOR
RPTOR independent companion of MTOR complex 2
IEP
associated with breast ductal carcinoma; protein:increased expression:breast tumor, lymph node (human)
RGD
PMID:20978191
RGD:152995469
NCBI chr 5:38,937,920...39,074,399
Ensembl chr 5:38,937,920...39,074,402
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RUNX1
RUNX family transcription factor 1
IEP
associated with Carcinoid Tumor
RGD
PMID:21636701
RGD:126779567
NCBI chr21:34,787,801...35,049,302
Ensembl chr21:34,787,801...36,004,667
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SFN
stratifin
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:19381893
NCBI chr 1:26,863,149...26,864,456
Ensembl chr 1:26,863,149...26,864,456
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SKP2
S-phase kinase associated protein 2
IEP
associated with Endometrial Neoplasms;protein:increased expression:endometrium
RGD
PMID:16080017
RGD:2315043
NCBI chr 5:36,152,111...36,193,530
Ensembl chr 5:36,151,989...36,196,849
G
SLC22A10
solute carrier family 22 member 10
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:30705370
NCBI chr11:63,289,903...63,363,144
Ensembl chr11:63,268,022...63,311,783
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SLC7A5
solute carrier family 7 member 5
severity
IEP
associated with stomach carcinoma associated with gastric adenocarcinoma;protein:increased expression: :
RGD
PMID:25908107 PMID:21501294
RGD:11052781 , RGD:151361203
NCBI chr16:87,830,023...87,869,507
Ensembl chr16:87,830,023...87,869,507
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SMAD4
SMAD family member 4
IEP
associated with Breast Neoplasms
RGD
PMID:11809701
RGD:2300007
NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,528...51,085,045
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SMO
smoothened, frizzled class receptor
IEP
associated with colorectal cancer
RGD
PMID:30784110
RGD:150520177
NCBI chr 7:129,188,633...129,213,545
Ensembl chr 7:129,188,633...129,213,545
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SNCG
synuclein gamma
IEP
RGD
PMID:15221989
RGD:6478801
NCBI chr10:86,955,759...86,963,258
Ensembl chr10:86,958,599...86,963,258
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SOCS2
suppressor of cytokine signaling 2
IEP
associated with Prostatic Neoplasms
RGD
PMID:16707422
RGD:2298925
NCBI chr12:93,569,969...93,626,236
Ensembl chr12:93,569,814...93,583,487
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SOCS3
suppressor of cytokine signaling 3
IEP
associated with Breast Neoplasms
RGD
PMID:18097573
RGD:2298901
NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
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SOD2
superoxide dismutase 2
disease_progression
IEP EXP
associated with tongue neoplasms; CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:10853026 PMID:19381893 PMID:20618948 PMID:20618948
RGD:8547519
NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
G
SOX2
SRY-box transcription factor 2
disease_progression
IEP
associated with Breast Neoplasms
RGD
PMID:24382260
RGD:8661670
NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436
G
SRC
SRC proto-oncogene, non-receptor tyrosine kinase
HEP
associated with colon adenocarcinoma,
RGD
PMID:21282564
RGD:150520218
NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050
G
ST14
ST14 transmembrane serine protease matriptase
IEP
associated with Endometrial Neoplasms
RGD
PMID:19443387
RGD:2315087
NCBI chr11:130,159,782...130,210,362
Ensembl chr11:130,159,782...130,210,362
G
STAT3
signal transducer and activator of transcription 3
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549414
NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
G
STK11
serine/threonine kinase 11
IEP
associated with Breast Neoplasms;protein:decreased expression
RGD
PMID:12114407
RGD:2291948
NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431
G
TERT
telomerase reverse transcriptase
disease_progression
IEP
associated with lung non-small cell carcinoma;
RGD
PMID:11679180
RGD:152977755
NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068
G
TIMP1
TIMP metallopeptidase inhibitor 1
IEP
associated with Endometrial Neoplasms;protein:increased expression:endometrium
RGD
PMID:12487935
RGD:2298523
NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789
G
TIMP3
TIMP metallopeptidase inhibitor 3
IEP
associated with Breast Neoplasms;mRNA:increased expression:breast
RGD
PMID:12828172
RGD:2290437
NCBI chr22:32,801,705...32,863,041
Ensembl chr22:32,801,705...32,863,041
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TIMP4
TIMP metallopeptidase inhibitor 4
IEP
associated with Breast Neoplasms;mRNA:increased expression:breast
RGD
PMID:12828172
RGD:2290437
NCBI chr 3:12,153,068...12,158,912
Ensembl chr 3:12,153,068...12,158,912
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TLR4
toll like receptor 4
IEP
associated with Carcinoma, Ductal, Breast;
RGD
PMID:23338716
RGD:7794684
NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
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TP53
tumor protein p53
IEP IAGP ISO
associated with Penile Neoplasms associated with Breast Neoplasms;DNA:missense mutation, duplication:cds, intron:p.R72P associated with Carcinoma, Squamous Cell;
RGD
PMID:18268397 PMID:18230179 PMID:18059331
RGD:2290533 , RGD:2290534 , RGD:8547790
NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
G
TP53BP1
tumor protein p53 binding protein 1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:30705370
NCBI chr15:43,403,061...43,510,640
Ensembl chr15:43,403,061...43,510,728
G
TRMT11
tRNA methyltransferase 11 homolog
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:30705370
NCBI chr 6:125,986,540...126,272,343
Ensembl chr 6:125,986,479...126,203,817
G
TSC2
TSC complex subunit 2
IEP
associated with Breast Neoplasms
RGD
PMID:15951164
RGD:11568707
NCBI chr16:2,047,985...2,089,491
Ensembl chr16:2,047,967...2,089,491
G
TSHR
thyroid stimulating hormone receptor
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:9062474
NCBI chr14:80,955,621...81,146,306
Ensembl chr14:80,954,989...81,146,306
G
TTR
transthyretin
IEP
associated with colorectal cancer;protein:decreased expresion:blood serum (human)
RGD
PMID:21074777
RGD:151665155
NCBI chr18:31,591,877...31,598,821
Ensembl chr18:31,557,009...31,598,833
G
TYMP
thymidine phosphorylase
IEP
associated with Breast Neoplasms associated with Cholangiocarcinoma
RGD
PMID:10685502 PMID:11927969
RGD:2293725 , RGD:2325027
NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032
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VEGFA
vascular endothelial growth factor A
IEP ISO
associated with Cervix Neoplasms associated with Breast neoplasms;
RGD
PMID:19783962 PMID:17597103
RGD:2315454 , RGD:7421574
NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
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VEGFC
vascular endothelial growth factor C
disease_progression exacerbates
IEP
associated with Carcinoma, Transitional Cell;protein:increased expression:urinary bladder associated with Prostatic Neoplasms associated with Cervix Neoplasms associated with Breast Neoplasms associated with thyroid diseases;mRNA:increased expression:thyroid gland: associated with Lymphatic Metastasis; associated with pancreatic adenocarcinoma;protein:increased expression:pancreas (human)
RGD
PMID:17034609 PMID:19608016 PMID:19589137 PMID:19923084 PMID:12203051 PMID:15289890 PMID:18061373 More...
RGD:2315484 , RGD:2315474 , RGD:2315475 , RGD:2315469 , RGD:7483611 , RGD:7488946 , RGD:155630642
NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922
G
VEGFD
vascular endothelial growth factor D
IEP
associated with Cervix Neoplasms associated with Breast Neoplasms
RGD
PMID:19589137 PMID:17951197
RGD:2315475 , RGD:2315480
NCBI chr X:15,345,596...15,384,413
Ensembl chr X:15,345,596...15,384,413
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WRAP53
WD repeat containing antisense to TP53
IEP
associated with lung non-small cell carcinoma; associated with esophagus squamous cell carcinoma;
RGD
PMID:31281482 PMID:24626331
RGD:21081513 , RGD:21081532
NCBI chr17:7,686,071...7,703,502
Ensembl chr17:7,686,071...7,703,502
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