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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Lymphatic Metastasis
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Accession:DOID:9000081 term browser browse the term
Definition:Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Synonyms:exact_synonym: Lymphatic Metastases
 narrow_synonym: lymph node metastatic carcinoma
 primary_id: MESH:D008207;   RDO:0006041
 xref: EFO:0004906;   EFO:1001364



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Lymphatic Metastasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA13 ATP binding cassette subfamily A member 13 susceptibility IAGP DNA:amplification:cds: (human, male) RGD PMID:27366209 RGD:152995256 NCBI chr 7:48,171,458...48,647,497
Ensembl chr 7:48,171,458...48,647,497
JBrowse link
G ADAM28 ADAM metallopeptidase domain 28 IDA associated with breast cancer;DNA:hypermethylation: RGD PMID:25620615 RGD:153298970 NCBI chr 8:24,294,069...24,359,014
Ensembl chr 8:24,294,069...24,359,014
JBrowse link
G ADGRB1 adhesion G protein-coupled receptor B1 disease_progression IEP associated with stomach cancer; RGD PMID:11172604 RGD:13831357 NCBI chr 8:142,449,649...142,545,007
Ensembl chr 8:142,449,430...142,545,009
JBrowse link
G AGAP2-AS1 AGAP2 antisense RNA 1 IEP associated with non-small cell lung carcinoma; RGD PMID:28617550 RGD:13838847 NCBI chr12:57,726,240...57,728,356
Ensembl chr12:57,726,271...57,728,356
JBrowse link
G AICDA activation induced cytidine deaminase IEP associated with stomach cancer;protein:increased expression:stomach (human) RGD PMID:21538122 RGD:127285638 NCBI chr12:8,602,170...8,612,859
Ensembl chr12:8,602,155...8,613,242
JBrowse link
G ANGPTL4 angiopoietin like 4 EXP CTD Direct Evidence: therapeutic CTD PMID:17130448 NCBI chr19:8,364,155...8,374,370
Ensembl chr19:8,363,289...8,374,370
JBrowse link
G ANXA1 annexin A1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393
JBrowse link
G AQP3 aquaporin 3 (Gill blood group) EXP CTD Direct Evidence: marker/mechanism CTD PMID:21401805 NCBI chr 9:33,441,160...33,447,593
Ensembl chr 9:33,441,156...33,447,596
JBrowse link
G ARHGAP5 Rho GTPase activating protein 5 IEP associated with nasopharynx carcinoma;mRNA, protein:increased expression: epithelium of nasopharynx RGD PMID:25961434 RGD:11056278 NCBI chr14:32,077,304...32,159,728
Ensembl chr14:32,076,114...32,159,728
JBrowse link
G ASXL1 ASXL transcriptional regulator 1 IEP associated with colorectal cancer RGD PMID:32317519 RGD:126779580 NCBI chr20:32,358,331...32,439,319
Ensembl chr20:32,358,330...32,439,319
JBrowse link
G AXL AXL receptor tyrosine kinase IEP associated Pancreatic Neoplasms RGD PMID:19252414 RGD:2325833 NCBI chr19:41,219,223...41,261,766
Ensembl chr19:41,219,223...41,261,766
JBrowse link
G BAG1 BAG cochaperone 1 disease_progression IEP associated with Breast Neoplasms:protein:increased expression:breast RGD PMID:18430249 RGD:2292908 NCBI chr 9:33,252,471...33,264,708
Ensembl chr 9:33,247,820...33,264,720
JBrowse link
G BAMBI BMP and activin membrane bound inhibitor IEP associated with stomach cancer; protein:increased expression: : RGD PMID:24752577 RGD:14390158 NCBI chr10:28,677,521...28,682,932
Ensembl chr10:28,677,510...28,682,932
JBrowse link
G BARHL2 BarH like homeobox 2 IEP associated with oral squamous cell carcinoma; mRNA:decreased expression:mouth mucosa RGD PMID:27542258 RGD:14390167 NCBI chr 1:90,711,539...90,717,302
Ensembl chr 1:90,711,539...90,717,302
JBrowse link
G BCL2 BCL2 apoptosis regulator IEP associated with Breast Neoplasms;protein:increased expression:lymph node RGD PMID:18217456 RGD:2293013 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BIK BCL2 interacting killer IAGP associated with cholangiocarcinoma;DNA:CNV:: RGD PMID:16865775 RGD:14394820 NCBI chr22:43,110,750...43,129,712
Ensembl chr22:43,110,750...43,129,712
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 disease_progression IEP associated with Cervix Neoplasms;mRNA:splice variant
associated with Breast Neoplasms
RGD PMID:17877643 PMID:17285241 RGD:2293098, RGD:2293103 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase EXP CTD Direct Evidence: marker/mechanism CTD PMID:29426936 NCBI chr 7:140,713,328...140,924,929
Ensembl chr 7:140,719,327...140,924,929
JBrowse link
G BRD7 bromodomain containing 7 severity IEP protein:increased expression:lung: RGD PMID:22008115 RGD:9586442 NCBI chr16:50,315,957...50,368,988
Ensembl chr16:50,313,487...50,368,988
JBrowse link
G BSG basigin (Ok blood group) disease_progression IEP associated with Breast Neoplasms RGD PMID:16004819 RGD:2289055 NCBI chr19:571,283...583,493
Ensembl chr19:571,277...583,494
JBrowse link
G BTK Bruton tyrosine kinase disease_progression IEP associated with lung adenocarcinoma;protein:increased expression:lung (human) RGD PMID:31200752 RGD:151347847 NCBI chr  X:101,349,450...101,390,796
Ensembl chr  X:101,349,338...101,390,796
JBrowse link
G CA9 carbonic anhydrase 9 IEP associated with Cervix Neoplasms RGD PMID:17233814 RGD:2293196 NCBI chr 9:35,673,928...35,681,159
Ensembl chr 9:35,673,928...35,681,159
JBrowse link
G CAB39 calcium binding protein 39 IEP associated with pancreatic cancer;RNA:increased expression:pancreas RGD PMID:28197410 RGD:14398834 NCBI chr 2:230,712,842...230,821,075
Ensembl chr 2:230,712,842...230,821,075
JBrowse link
G CASP9 caspase 9 IAGP associated with Carcinoma, Non-Small-Cell Lung;DNA:SNP:exon:rs1052576 (human) RGD PMID:17285546 RGD:13434907 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAV1 caveolin 1 disease_progression IEP associated with Melanoma RGD PMID:22134245 RGD:8661767 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179
JBrowse link
G CBL Cbl proto-oncogene IEP associated with stomach carcinoma;protein:increased expression:stomach RGD PMID:31611438 RGD:126925223 NCBI chr11:119,206,339...119,308,149
Ensembl chr11:119,206,298...119,313,926
JBrowse link
G CBLB Cbl proto-oncogene B IEP associated with stomach carcinoma; RGD PMID:20038312 RGD:150540338 NCBI chr 3:105,655,461...105,869,449
Ensembl chr 3:105,655,461...105,869,552
JBrowse link
G CCND2 cyclin D2 IEP associated with colorectal cancer;protein:increased expression:colorectum RGD PMID:19508551 RGD:151665111 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353
JBrowse link
G CCNE1 cyclin E1 IEP associated with Carcinoma, Transitional Cell;protein:decreased expression RGD PMID:16949911 RGD:2289266 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CCNH cyclin H EXP CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr 5:87,311,471...87,412,930
Ensembl chr 5:87,318,416...87,413,029
JBrowse link
G CCR5 C-C motif chemokine receptor 5 IEP associated with Breast Neoplasms;mRNA:increased expression:lymph node RGD PMID:24301790 RGD:8551816 NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,946...46,376,206
JBrowse link
G CD274 CD274 molecule EXP CTD Direct Evidence: marker/mechanism CTD PMID:16530813 NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566
JBrowse link
G CD40 CD40 molecule IAGP associated with breast cancer;DNA:snps:5' utr, intron:c.-1T>C, c.51+914T>G (rs1883832, rs4810485) (human) RGD PMID:21912605 RGD:8547780 NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863
JBrowse link
G CD44 CD44 molecule (IN blood group) IDA associated with Breast Neoplasms, Colorectal Neoplasms, Stomach Neoplasms;mRNA, protein:splice variant, increased expression:breast, large intestine, stomach RGD PMID:16425351 RGD:2289356 NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402
JBrowse link
G CDH1 cadherin 1 IEP associated with Cervix Neoplasms
associated with Breast Neoplasms
RGD PMID:18097581 PMID:17649807 RGD:2296046, RGD:2289498 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A IEP associated with Eyelid Neoplasms;
associated with Oral Squamous Cell Carcinoma;
RGD PMID:19628749 PMID:15817070 RGD:8661799, RGD:8662374 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B IEP associated with Breast Neoplasms
associated with non-small cell lung carcinoma
RGD PMID:12015771 PMID:28601655 RGD:2293607, RGD:13673921 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A EXP CTD Direct Evidence: marker/mechanism CTD PMID:29426936 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301
JBrowse link
G CLDN1 claudin 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:33665778 NCBI chr 3:190,305,707...190,322,446
Ensembl chr 3:190,305,707...190,322,446
JBrowse link
G CLPTM1L CLPTM1 like IEP associated with esophagus squamous cell carcinoma; mRNA:increased expression:esophagus RGD PMID:25480402 RGD:150530497 NCBI chr 5:1,317,752...1,345,099
Ensembl chr 5:1,317,752...1,345,099
JBrowse link
G CLU clusterin IAGP associated with breast cancer;DNA:snp:promoter:g.27611345C>G (rs9331888) (human) RGD PMID:22037783 RGD:8963167 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700
JBrowse link
G COMT catechol-O-methyltransferase IAGP associated with breast cancer;DNA:missense mutation:cds:p.V108/158M (human) RGD PMID:10755383 RGD:8662330 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975
JBrowse link
G CRP C-reactive protein susceptibility IAGP associated with Breast Neoplasm; DNA:polymorphism: :1846C>T(rs1205)(human) RGD PMID:24633920 RGD:9580226 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G CSF1R colony stimulating factor 1 receptor IEP associated with Breast Neoplasms RGD PMID:14734466 RGD:2293711 NCBI chr 5:150,053,295...150,113,365
Ensembl chr 5:150,053,291...150,113,372
JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO associated with Prostatic Neoplasms RGD PMID:10611340 RGD:4891523 NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,853,888...203,873,965
JBrowse link
G CTNNA1 catenin alpha 1 IEP associated with Breast Neoplasms RGD PMID:12047765 RGD:2289795 NCBI chr 5:138,753,425...138,935,034
Ensembl chr 5:138,610,967...138,935,034
JBrowse link
G CTNNB1 catenin beta 1 IEP associated with Breast Neoplasms;protein:decreased expression RGD PMID:17908479 RGD:2289813 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 disease_progression IEP associated with stomach cancer;mRNA:increased expression:stomach (human) RGD PMID:21633638 RGD:152023624 NCBI chr10:44,370,165...44,385,097
Ensembl chr10:44,370,165...44,386,493
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 IEP associated with nasopharynx carcinoma; protein:increased expression:lymph node (human) RGD PMID:16000558 RGD:151893515 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177
JBrowse link
G CYCS cytochrome c, somatic IDA associated with non-small cell lung carcinoma; protein:decreased expression:serum RGD PMID:25578497 RGD:13792769 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G DDR1 discoidin domain receptor tyrosine kinase 1 severity IEP mRNA, protein:increased expression:mouth (human)
mRNA:increased expression:kidney, lymph nodes (human)
RGD PMID:31253192 PMID:27020590 RGD:151347620, RGD:151347863 NCBI chr 6:30,880,970...30,900,156
Ensembl chr 6:30,876,421...30,900,156
JBrowse link
G DDR2 discoidin domain receptor tyrosine kinase 2 disease_progression IDA associated with oral squamous cell carcinoma RGD PMID:29945346 RGD:150429700 NCBI chr 1:162,630,863...162,787,405
Ensembl chr 1:162,631,373...162,787,405
JBrowse link
G DNMT3B DNA methyltransferase 3 beta IEP associated with Carcinoma, Pancreatic Ductal; RGD PMID:22919364 RGD:9589121 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,359
JBrowse link
G EBAG9 estrogen receptor binding site associated antigen 9 IEP associated with Breast Neoplasms;protein:increased expression:breast
associated with Prostatic Neoplasm;protein:increased expression:prostate gland, lymph node
RGD PMID:12054692 PMID:12845666 PMID:17187007 RGD:2298489, RGD:2289856, RGD:2289847 NCBI chr 8:109,539,702...109,565,996
Ensembl chr 8:109,539,711...109,570,072
JBrowse link
G EGFR epidermal growth factor receptor treatment ISO associated with Squamous Cell Carcinoma of the Tongue RGD PMID:19380367 RGD:8551769 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EHMT2 euchromatic histone lysine methyltransferase 2 IEP associated with Melanoma;
associated with Esophageal Squamous Cell Carcinoma;
RGD PMID:24658378 PMID:24805087 RGD:9590069, RGD:9590071 NCBI chr 6:31,879,759...31,897,698
Ensembl chr 6:31,879,759...31,897,698
JBrowse link
G EPHA2 EPH receptor A2 IEP protein:increased expression:esophagus (human) RGD PMID:33833989 RGD:153344568 NCBI chr 1:16,124,337...16,156,069
Ensembl chr 1:16,124,337...16,156,069
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 disease_progression IEP
EXP
associated with Carcinoma, Transitional Cell;protein:increased expression:urinary bladder
associated with Breast Neoplasms;DNA, protein:polymorphism, increased expression:serum:p.I655V
CTD Direct Evidence: marker/mechanism
associated with lung adenocarcinoma; protein:increased expression:lung (human)
CTD
RGD
PMID:21532492 PMID:18097576 PMID:18237248 PMID:21966491 RGD:2289926, RGD:2289925, RGD:153344600 NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426
JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 IEP associated with Prostatic Neoplasms;protein:increased expression, altered localization:lymph node, nucleus
associated with head and neck squamous cell carcinoma
RGD PMID:17634423 PMID:20604875 RGD:2289944, RGD:126790467 NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505
JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 severity
disease_progression
IEP associated with oral squamous cell carcinoma
associated with colorectal adenocarcinoma
associated with lung non-small cell carcinoma
RGD PMID:27444519 PMID:16507107 PMID:21324275 RGD:126781762, RGD:126781766, RGD:126790471 NCBI chr 2:211,375,717...212,538,802
Ensembl chr 2:211,375,717...212,538,841
JBrowse link
G FAS Fas cell surface death receptor susceptibility IAGP associated with Cervix Neoplasms;DNA:polymorphism:promoter:-1377G>A RGD PMID:18068525 RGD:2298509 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
JBrowse link
G FGF1 fibroblast growth factor 1 IEP associated with Cervix Neoplasms;mRNA:increased expression:lymph node RGD PMID:17242701 RGD:2290286 NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 IAGP associated with breast cancer;DNA:snp:intron:c.109+7033T>A (rs1219648) (human) RGD PMID:20640597 RGD:7394846 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458
JBrowse link
G FLT3 fms related receptor tyrosine kinase 3 disease_progression ISO associated with Prostatic Neoplasms RGD PMID:14566827 RGD:2302210 NCBI chr13:28,003,274...28,100,576
Ensembl chr13:28,003,274...28,100,592
JBrowse link
G FOXA1 forkhead box A1 IEP associated with lung non-small cell carcinoma; mRNA:increased expression: : RGD PMID:29115441 RGD:151665751 NCBI chr14:37,589,552...37,595,249
Ensembl chr14:37,589,552...37,596,059
JBrowse link
G FOXP1 forkhead box P1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25485836 NCBI chr 3:70,954,708...71,583,978
Ensembl chr 3:70,954,693...71,583,978
JBrowse link
G GPX3 glutathione peroxidase 3 IDA associated with stomach carcinoma; DNA:hypermethylation:promoter RGD PMID:23071548 RGD:151665353 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988
JBrowse link
G GRIK2 glutamate ionotropic receptor kainate type subunit 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr 6:101,393,708...102,070,083
Ensembl chr 6:100,962,701...102,081,622
JBrowse link
G HMGB1 high mobility group box 1 ISO associated with Adenocarcinoma, Colon RGD PMID:20616616 RGD:10402080 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G ICAM1 intercellular adhesion molecule 1 IEP associated with Breast Neoplasms RGD PMID:21590495 RGD:8547712 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IER2 immediate early response 2 ISO RGD PMID:22120713 RGD:153323322 NCBI chr19:13,150,411...13,154,911
Ensembl chr19:13,150,411...13,154,911
JBrowse link
G IL13 interleukin 13 IEP associated with Melanoma, Cutaneous Malignant;mRNA:increased expression:lymph node RGD PMID:17545514 RGD:8549587 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
JBrowse link
G IL18 interleukin 18 IEP associated with Breast Neoplasms;protein:increased expression:serum RGD PMID:12902898 RGD:8655867 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G ING4 inhibitor of growth family member 4 EXP CTD Direct Evidence: therapeutic CTD PMID:27806345 NCBI chr12:6,650,301...6,663,119
Ensembl chr12:6,650,301...6,663,142
JBrowse link
G IQSEC1 IQ motif and Sec7 domain ArfGEF 1 disease_progression IEP associated with lung adenocarcinoma; protein:increased expression:lung (human) RGD PMID:21966491 RGD:153344600 NCBI chr 3:12,897,043...13,283,257
Ensembl chr 3:12,897,043...13,283,281
JBrowse link
G ITGB1 integrin subunit beta 1 IEP associated with non-small cell lung carcinoma, RGD PMID:28537888 RGD:13792830 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792
JBrowse link
G KCNJ12 potassium inwardly rectifying channel subfamily J member 12 EXP CTD Direct Evidence: marker/mechanism CTD PMID:34755307 NCBI chr17:21,376,357...21,419,870
Ensembl chr17:21,376,357...21,419,870
JBrowse link
G KDR kinase insert domain receptor treatment ISO associated with Squamous Cell Carcinoma of the Tongue RGD PMID:19380367 RGD:8551769 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
JBrowse link
G KISS1 KiSS-1 metastasis suppressor EXP CTD Direct Evidence: therapeutic CTD PMID:21383688 NCBI chr 1:204,190,341...204,196,491
Ensembl chr 1:204,190,341...204,196,491
JBrowse link
G KLF7 KLF transcription factor 7 EXP CTD Direct Evidence: therapeutic CTD PMID:37734194 NCBI chr 2:207,074,137...207,173,851
Ensembl chr 2:207,074,137...207,173,856
JBrowse link
G KMT2D lysine methyltransferase 2D IEP associated with stomach cancer RGD PMID:30177394 RGD:150521710 NCBI chr12:49,018,978...49,060,794
Ensembl chr12:49,018,975...49,060,794
JBrowse link
G LAMC2 laminin subunit gamma 2 IEP associated with lung squamous cell carcinoma; RGD PMID:23124251 RGD:13793371 NCBI chr 1:183,186,264...183,258,968
Ensembl chr 1:183,186,238...183,245,127
JBrowse link
G LRRC59 leucine rich repeat containing 59 EXP CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr17:50,381,238...50,397,523
Ensembl chr17:50,375,059...50,397,523
JBrowse link
G MACIR macrophage immunometabolism regulator EXP CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr 5:103,258,374...103,278,660
Ensembl chr 5:103,258,763...103,278,660
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase EXP CTD Direct Evidence: marker/mechanism CTD PMID:29426936 NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377
JBrowse link
G MIR125A microRNA 125a IEP associated with stomach cancer; RGD PMID:22322911 RGD:21408544 NCBI chr19:51,693,254...51,693,339
Ensembl chr19:51,693,254...51,693,339
JBrowse link
G MIR152 microRNA 152 IEP associated with breast cancer RGD PMID:22935141 RGD:19165152 NCBI chr17:48,037,161...48,037,247
Ensembl chr17:48,037,161...48,037,247
JBrowse link
G MIR155 microRNA 155 disease_progression IEP associated with colon cancer RGD PMID:26885061 PMID:27856635 PMID:29893326 RGD:21079444, RGD:21079446, RGD:21409756 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044
JBrowse link
G MIR187 microRNA 187 IEP associated with oral squamous cell carcinoma; RNA:increased expression:plasma RGD PMID:27542258 RGD:14390167 NCBI chr18:35,904,818...35,904,926
Ensembl chr18:35,904,818...35,904,926
JBrowse link
G MIR224 microRNA 224 IEP associated with colorectal cancer; mRNA:decreased expression:colorectal mucosa: RGD PMID:25919696 RGD:14398749 NCBI chr  X:151,958,578...151,958,658
Ensembl chr  X:151,958,578...151,958,658
JBrowse link
G MIR30A microRNA 30a IEP associated with Colorectal Neoplasms RGD PMID:23486085 RGD:13432035 NCBI chr 6:71,403,551...71,403,621
Ensembl chr 6:71,403,551...71,403,621
JBrowse link
G MIR335 microRNA 335 IEP associated with stomach cancer; RNA:decreased expression:stomach RGD PMID:21822301 RGD:14394425 NCBI chr 7:130,496,111...130,496,204
Ensembl chr 7:130,496,111...130,496,204
JBrowse link
G MIR432 microRNA 432 disease_progression IEP mRNA:decreased expression:colon (human) RGD PMID:33717244 RGD:152999433 NCBI chr14:100,884,483...100,884,576
Ensembl chr14:100,884,483...100,884,576
JBrowse link
G MMP2 matrix metallopeptidase 2 disease_progression IEP associated with Tongue Neoplasms
associated with Carcinoma, Ductal, Breast
RGD PMID:23107277 PMID:23280016 RGD:8547824, RGD:8655998 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP3 matrix metallopeptidase 3 IAGP associated with breast cancer;DNA:deletion:promoter:-1170_-1172delA (human) RGD PMID:15161710 RGD:8662937 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
JBrowse link
G MMP9 matrix metallopeptidase 9 disease_progression IEP associated with Carcinoma, Non-Small-Cell Lung;protein:increased expression:serum
associated with Endometrial Neoplasms;protein:increased expression:endometrium
associated with Tongue Neoplasms
RGD PMID:20704821 PMID:12487935 PMID:23107277 RGD:5129215, RGD:2298523, RGD:8547824 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MSH2 mutS homolog 2 IEP associated with laryngeal squamous cell carcinoma RGD PMID:24459922 RGD:126848797 NCBI chr 2:47,403,067...47,709,830
Ensembl chr 2:47,403,067...47,663,146
JBrowse link
G MSLN mesothelin EXP CTD Direct Evidence: marker/mechanism CTD PMID:22644300 NCBI chr16:760,734...768,865
Ensembl chr16:760,734...768,865
JBrowse link
G MT1A metallothionein 1A EXP CTD Direct Evidence: marker/mechanism CTD PMID:17418620 NCBI chr16:56,638,666...56,640,087
Ensembl chr16:56,638,666...56,640,087
JBrowse link
G MTA1 metastasis associated 1 IEP associated with Carcinoma, Non-Small-Cell Lung;mRNA:increased expression:lung RGD PMID:11804687 RGD:9588220 NCBI chr14:105,419,827...105,470,729
Ensembl chr14:105,419,820...105,470,729
JBrowse link
G MTOR mechanistic target of rapamycin kinase EXP CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556
JBrowse link
G MUC1 mucin 1, cell surface associated IEP associated with Common Bile Duct Neoplasms
associated with Gallbladder Neoplasms;protein:altered localization:gallbladder
associated with Carcinoma, Renal Cell;
associated with Esophageal Neoplasms
RGD PMID:16222735 PMID:11295067 PMID:10390012 PMID:21339746 RGD:2324649, RGD:2324860, RGD:7245968, RGD:7349383 NCBI chr 1:155,185,824...155,192,915
Ensembl chr 1:155,185,824...155,192,916
JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming IEP associated with chloangiocarcinoma;protein:increased expression:bile duct RGD PMID:16842244 RGD:2325168 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138
JBrowse link
G NCAM1 neural cell adhesion molecule 1 ISO RGD PMID:10086383 RGD:2326067 NCBI chr11:112,961,420...113,278,436
Ensembl chr11:112,961,275...113,278,436
JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 IEP associated with Cervix Neoplasms; associated with Endometrial Neoplasms
associated with Breast Neoplasms
RGD PMID:8855975 PMID:9036878 PMID:8102131 RGD:2299062, RGD:2299061, RGD:2299077 NCBI chr17:51,153,559...51,162,168
Ensembl chr17:51,153,559...51,162,428
JBrowse link
G NME2 NME/NM23 nucleoside diphosphate kinase 2 IEP associated with Cervix Neoplasms; associated with Endometrial Neoplasms RGD PMID:8855975 RGD:2299062 NCBI chr17:51,165,536...51,171,744
Ensembl chr17:51,165,435...51,171,744
JBrowse link
G NOS3 nitric oxide synthase 3 susceptibility IAGP associated with Breast Neoplasms;DNA:polymorphisms:promoter, exon:-786T>C,p.E298D (human) RGD PMID:17262178 RGD:2292070 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase IAGP associated with breast cancer;DNA:missense mutation:cds:p.S326C (rs1052133) (human) RGD PMID:18977234 RGD:8657156 NCBI chr 3:9,749,952...9,783,108
Ensembl chr 3:9,749,944...9,788,219
JBrowse link
G PAGR1 PAXIP1 associated glutamate rich protein 1 disease_progression IEP protein:decreased expression:esophagus (human) RGD PMID:33833989 RGD:153344568 NCBI chr16:29,816,152...29,822,489
Ensembl chr16:29,816,152...29,822,489
JBrowse link
G PDGFA platelet derived growth factor subunit A IEP associated with Breast Neoplasms;mRNA:increased expression:breast RGD PMID:8619189 RGD:2292155 NCBI chr 7:497,258...520,700
Ensembl chr 7:497,258...520,296
JBrowse link
G PDGFB platelet derived growth factor subunit B IEP associated with Breast Neoplasms;mRNA:increased expression:lymph node RGD PMID:17674348 RGD:2292173 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982
JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 IEP associated with non-small cell lung carcinoma;mRNA:increased expression:blood serum RGD PMID:25064732 RGD:13503320 NCBI chr16:2,538,021...2,603,188
Ensembl chr16:2,537,979...2,603,188
JBrowse link
G PDPN podoplanin IEP associated with Cervix Neoplasms
associated with Breast Neoplasms
RGD PMID:16528371 PMID:18165897 RGD:2292237, RGD:2292231 NCBI chr 1:13,583,757...13,617,957
Ensembl chr 1:13,583,465...13,617,957
JBrowse link
G PEBP1 phosphatidylethanolamine binding protein 1 IEP associated with Breast Neoplasms
associated with Cervix Neoplasms
RGD PMID:16243812 PMID:18191186 RGD:2302868, RGD:2302867 NCBI chr12:118,136,124...118,145,584
Ensembl chr12:118,136,124...118,145,584
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IEP associated with Colorectal Neoplasms RGD PMID:25550888 RGD:13432030 NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093
JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta IEP associated with Colorectal Neoplasms RGD PMID:25550888 RGD:13432030 NCBI chr 3:138,652,698...138,834,928
Ensembl chr 3:138,652,698...138,834,928
JBrowse link
G PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type 1 alpha EXP CTD Direct Evidence: marker/mechanism CTD PMID:34755307 NCBI chr 1:151,195,419...151,249,531
Ensembl chr 1:151,197,949...151,249,536
JBrowse link
G POU5F1 POU class 5 homeobox 1 IEP associated with Seminoma; associated with Carcinoma, Embryonal RGD PMID:15386301 RGD:2292442 NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma IEP associated with Cholangiocarcinoma;protein:increased expression:bile duct epithelium RGD PMID:20021832 RGD:2317459 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PREX1 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 IMP associated with Prostatic Neoplasms RGD PMID:19305425 RGD:2314605 NCBI chr20:48,624,252...48,888,185
Ensembl chr20:48,624,252...48,827,999
JBrowse link
G PTEN phosphatase and tensin homolog IEP associated with Prostatic Neoplasms;protein:decreased expression:prostate
associated with Breast Neoplasms
RGD PMID:17163422 PMID:17919877 RGD:2292507, RGD:2292499 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 IEP
IAGP
associated with Biliary Tract Neoplasms
associated with Breast Neoplasms
associated with carcinoma, non-small-cell lung; DNA:SNP: :929G>C(human)
RGD PMID:18159174 PMID:18353210 PMID:20016751 RGD:2317165, RGD:2300128, RGD:5135471 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PTK2 protein tyrosine kinase 2 IEP associated with lung squamous cell carcinoma; protein:increased tyrosine phosphorylation:lymph node RGD PMID:23906871 RGD:152176664 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216
JBrowse link
G PTPN13 protein tyrosine phosphatase non-receptor type 13 IEP associated with lung squamous cell carcinoma; protein:decreased expression:lymph node RGD PMID:23906871 RGD:152176664 NCBI chr 4:86,594,315...86,815,161
Ensembl chr 4:86,594,315...86,815,171
JBrowse link
G RAMP2 receptor activity modifying protein 2 disease_progression HEP associated with colorectal cancer; protein:increased expression:lymph node (human) RGD PMID:23634287 RGD:151708733 NCBI chr17:42,761,227...42,763,041
Ensembl chr17:42,758,447...42,763,041
JBrowse link
G RAMP3 receptor activity modifying protein 3 HEP associated with colorectal cancer; protein:increased expression:lymph node (human) RGD PMID:23634287 RGD:151708733 NCBI chr 7:45,157,791...45,184,250
Ensembl chr 7:45,157,791...45,186,302
JBrowse link
G RASSF2 Ras association domain family member 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17013896 NCBI chr20:4,780,023...4,823,608
Ensembl chr20:4,780,023...4,823,608
JBrowse link
G RBM10 RNA binding motif protein 10 IAGP associated with lung adenocarcinoma;DNA:missense mutation:exon:p.R241C (c.763C>T) (human) RGD PMID:30405763 RGD:151356993 NCBI chr  X:47,145,221...47,186,813
Ensembl chr  X:47,145,221...47,186,813
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit IEP associated with Prostatic Neoplasms;protein:altered localization:nucleus, prostate gland RGD PMID:17020979 RGD:2298757 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G RET ret proto-oncogene IEP associated with Pancreatic Neoplasms RGD PMID:18652760 RGD:2324925 NCBI chr10:43,077,069...43,130,351
Ensembl chr10:43,077,064...43,130,351
JBrowse link
G RHOA ras homolog family member A IEP associated with Bladder Neoplasms;protein:increased expression:lymph node
associated with colorectal cancer
RGD PMID:12855641 PMID:17597401 RGD:2298872, RGD:13432052 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998
JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 IEP associated with breast ductal carcinoma; protein:increased expression:breast tumor, lymph node (human) RGD PMID:20978191 RGD:152995469 NCBI chr 5:38,937,920...39,074,399
Ensembl chr 5:38,937,920...39,074,402
JBrowse link
G RUNX1 RUNX family transcription factor 1 IEP associated with Carcinoid Tumor RGD PMID:21636701 RGD:126779567 NCBI chr21:34,787,801...35,049,302
Ensembl chr21:34,787,801...36,004,667
JBrowse link
G SFN stratifin EXP CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 1:26,863,149...26,864,456
Ensembl chr 1:26,863,149...26,864,456
JBrowse link
G SKP2 S-phase kinase associated protein 2 IEP associated with Endometrial Neoplasms;protein:increased expression:endometrium RGD PMID:16080017 RGD:2315043 NCBI chr 5:36,152,111...36,193,530
Ensembl chr 5:36,151,989...36,196,849
JBrowse link
G SLC22A10 solute carrier family 22 member 10 EXP CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr11:63,289,903...63,363,144
Ensembl chr11:63,268,022...63,311,783
JBrowse link
G SLC7A5 solute carrier family 7 member 5 severity IEP associated with stomach carcinoma
associated with gastric adenocarcinoma;protein:increased expression: :
RGD PMID:25908107 PMID:21501294 RGD:11052781, RGD:151361203 NCBI chr16:87,830,023...87,869,507
Ensembl chr16:87,830,023...87,869,507
JBrowse link
G SMAD4 SMAD family member 4 IEP associated with Breast Neoplasms RGD PMID:11809701 RGD:2300007 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,528...51,085,045
JBrowse link
G SMO smoothened, frizzled class receptor IEP associated with colorectal cancer RGD PMID:30784110 RGD:150520177 NCBI chr 7:129,188,633...129,213,545
Ensembl chr 7:129,188,633...129,213,545
JBrowse link
G SNCG synuclein gamma IEP RGD PMID:15221989 RGD:6478801 NCBI chr10:86,955,759...86,963,258
Ensembl chr10:86,958,599...86,963,258
JBrowse link
G SOCS2 suppressor of cytokine signaling 2 IEP associated with Prostatic Neoplasms RGD PMID:16707422 RGD:2298925 NCBI chr12:93,569,969...93,626,236
Ensembl chr12:93,569,814...93,583,487
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 IEP associated with Breast Neoplasms RGD PMID:18097573 RGD:2298901 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
JBrowse link
G SOD2 superoxide dismutase 2 disease_progression IEP
EXP
associated with tongue neoplasms;
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:10853026 PMID:19381893 PMID:20618948 PMID:20618948 RGD:8547519 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOX2 SRY-box transcription factor 2 disease_progression IEP associated with Breast Neoplasms RGD PMID:24382260 RGD:8661670 NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase HEP associated with colon adenocarcinoma, RGD PMID:21282564 RGD:150520218 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050
JBrowse link
G ST14 ST14 transmembrane serine protease matriptase IEP associated with Endometrial Neoplasms RGD PMID:19443387 RGD:2315087 NCBI chr11:130,159,782...130,210,362
Ensembl chr11:130,159,782...130,210,362
JBrowse link
G STAT3 signal transducer and activator of transcription 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21549414 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
G STK11 serine/threonine kinase 11 IEP associated with Breast Neoplasms;protein:decreased expression RGD PMID:12114407 RGD:2291948 NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431
JBrowse link
G TERT telomerase reverse transcriptase disease_progression IEP associated with lung non-small cell carcinoma; RGD PMID:11679180 RGD:152977755 NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 IEP associated with Endometrial Neoplasms;protein:increased expression:endometrium RGD PMID:12487935 RGD:2298523 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 IEP associated with Breast Neoplasms;mRNA:increased expression:breast RGD PMID:12828172 RGD:2290437 NCBI chr22:32,801,705...32,863,041
Ensembl chr22:32,801,705...32,863,041
JBrowse link
G TIMP4 TIMP metallopeptidase inhibitor 4 IEP associated with Breast Neoplasms;mRNA:increased expression:breast RGD PMID:12828172 RGD:2290437 NCBI chr 3:12,153,068...12,158,912
Ensembl chr 3:12,153,068...12,158,912
JBrowse link
G TLR4 toll like receptor 4 IEP associated with Carcinoma, Ductal, Breast; RGD PMID:23338716 RGD:7794684 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TP53 tumor protein p53 IEP
IAGP
ISO
associated with Penile Neoplasms
associated with Breast Neoplasms;DNA:missense mutation, duplication:cds, intron:p.R72P
associated with Carcinoma, Squamous Cell;
RGD PMID:18268397 PMID:18230179 PMID:18059331 RGD:2290533, RGD:2290534, RGD:8547790 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr15:43,403,061...43,510,640
Ensembl chr15:43,403,061...43,510,728
JBrowse link
G TRMT11 tRNA methyltransferase 11 homolog EXP CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr 6:125,986,540...126,272,343
Ensembl chr 6:125,986,479...126,203,817
JBrowse link
G TSC2 TSC complex subunit 2 IEP associated with Breast Neoplasms RGD PMID:15951164 RGD:11568707 NCBI chr16:2,047,985...2,089,491
Ensembl chr16:2,047,967...2,089,491
JBrowse link
G TSHR thyroid stimulating hormone receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:9062474 NCBI chr14:80,955,621...81,146,306
Ensembl chr14:80,954,989...81,146,306
JBrowse link
G TTR transthyretin IEP associated with colorectal cancer;protein:decreased expresion:blood serum (human) RGD PMID:21074777 RGD:151665155 NCBI chr18:31,591,877...31,598,821
Ensembl chr18:31,557,009...31,598,833
JBrowse link
G TYMP thymidine phosphorylase IEP associated with Breast Neoplasms
associated with Cholangiocarcinoma
RGD PMID:10685502 PMID:11927969 RGD:2293725, RGD:2325027 NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032
JBrowse link
G VEGFA vascular endothelial growth factor A IEP
ISO
associated with Cervix Neoplasms
associated with Breast neoplasms;
RGD PMID:19783962 PMID:17597103 RGD:2315454, RGD:7421574 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G VEGFC vascular endothelial growth factor C disease_progression
exacerbates
IEP associated with Carcinoma, Transitional Cell;protein:increased expression:urinary bladder
associated with Prostatic Neoplasms
associated with Cervix Neoplasms
associated with Breast Neoplasms
associated with thyroid diseases;mRNA:increased expression:thyroid gland:
associated with Lymphatic Metastasis;
associated with pancreatic adenocarcinoma;protein:increased expression:pancreas (human)
RGD PMID:17034609 PMID:19608016 PMID:19589137 PMID:19923084 PMID:12203051 More... RGD:2315484, RGD:2315474, RGD:2315475, RGD:2315469, RGD:7483611, RGD:7488946, RGD:155630642 NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922
JBrowse link
G VEGFD vascular endothelial growth factor D IEP associated with Cervix Neoplasms
associated with Breast Neoplasms
RGD PMID:19589137 PMID:17951197 RGD:2315475, RGD:2315480 NCBI chr  X:15,345,596...15,384,413
Ensembl chr  X:15,345,596...15,384,413
JBrowse link
G WRAP53 WD repeat containing antisense to TP53 IEP associated with lung non-small cell carcinoma;
associated with esophagus squamous cell carcinoma;
RGD PMID:31281482 PMID:24626331 RGD:21081513, RGD:21081532 NCBI chr17:7,686,071...7,703,502
Ensembl chr17:7,686,071...7,703,502
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 97544
    disease of anatomical entity 91158
      immune system disease 15031
        lymphatic system disease 3166
          Lymphatic Metastasis 164
Path 2
Term Annotations click to browse term
  disease 97544
    disease of anatomical entity 91158
      Immune & Inflammatory Diseases 18550
        immune system disease 15031
          lymphatic system disease 3166
            Lymphatic Metastasis 164
paths to the root