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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Lymphatic Metastasis
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Accession:DOID:9000081 term browser browse the term
Definition:Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Synonyms:exact_synonym: Lymphatic Metastases
 narrow_synonym: lymph node metastatic carcinoma
 primary_id: MESH:D008207;   RDO:0006041
 xref: EFO:0004906;   EFO:1001364


show annotations for term's descendants           Sort by:
Lymphatic Metastasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA13 ATP binding cassette subfamily A member 13 susceptibility ISO DNA:amplification:cds: (human, male) RGD PMID:27366209 RGD:152995256 NCBI chr18:136,338...353,974
Ensembl chr18:135,690...352,871 		JBrowse link
G ADAM28 ADAM metallopeptidase domain 28 ISO associated with breast cancer;DNA:hypermethylation: RGD PMID:25620615 RGD:153298970 NCBI chr25:33,092,645...33,147,791
Ensembl chr25:33,092,628...33,264,710 		JBrowse link
G ADGRB1 adhesion G protein-coupled receptor B1 disease_progression ISO associated with stomach cancer; RGD PMID:11172604 RGD:13831357 NCBI chr13:36,627,791...36,649,013
Ensembl chr13:36,614,498...36,690,936 		JBrowse link
G AICDA activation induced cytidine deaminase ISO associated with stomach cancer;protein:increased expression:stomach (human) RGD PMID:21538122 RGD:127285638 NCBI chr27:37,064,107...37,073,791
Ensembl chr27:37,064,080...37,073,789 		JBrowse link
G ANGPTL4 angiopoietin like 4 ISO CTD Direct Evidence: therapeutic CTD PMID:17130448 NCBI chr20:52,942,090...52,948,126
Ensembl chr20:52,942,259...52,947,475 		JBrowse link
G ANXA1 annexin A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011 		JBrowse link
G AQP3 aquaporin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21401805 NCBI chr11:50,517,509...50,524,565 JBrowse link
G ARHGAP5 Rho GTPase activating protein 5 ISO associated with nasopharynx carcinoma;mRNA, protein:increased expression: epithelium of nasopharynx RGD PMID:25961434 RGD:11056278 NCBI chr 8:11,190,663...11,269,353
Ensembl chr 8:11,204,696...11,267,086 		JBrowse link
G ASXL1 ASXL transcriptional regulator 1 ISO associated with colorectal cancer RGD PMID:32317519 RGD:126779580 NCBI chr24:21,725,126...21,804,745
Ensembl chr24:21,661,059...21,802,815 		JBrowse link
G AXL AXL receptor tyrosine kinase ISO associated Pancreatic Neoplasms RGD PMID:19252414 RGD:2325833 NCBI chr 1:112,699,679...112,727,434
Ensembl chr 1:112,700,365...112,726,960 		JBrowse link
G BAG1 BAG cochaperone 1 disease_progression ISO associated with Breast Neoplasms:protein:increased expression:breast RGD PMID:18430249 RGD:2292908 NCBI chr11:50,348,833...50,363,532
Ensembl chr11:50,350,999...50,363,581 		JBrowse link
G BAMBI BMP and activin membrane bound inhibitor ISO associated with stomach cancer; protein:increased expression: : RGD PMID:24752577 RGD:14390158 NCBI chr 2:17,453,628...17,459,812
Ensembl chr 2:17,455,243...17,462,346 		JBrowse link
G BARHL2 BarH like homeobox 2 ISO associated with oral squamous cell carcinoma; mRNA:decreased expression:mouth mucosa RGD PMID:27542258 RGD:14390167 NCBI chr 6:57,971,077...57,977,197
Ensembl chr 6:57,971,018...57,977,211 		JBrowse link
G BCL2 BCL2 apoptosis regulator ISO associated with Breast Neoplasms;protein:increased expression:lymph node RGD PMID:18217456 RGD:2293013 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658 		JBrowse link
G BIK BCL2 interacting killer ISO associated with cholangiocarcinoma;DNA:CNV:: RGD PMID:16865775 RGD:14394820 NCBI chr10:22,417,374...22,433,055 JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 disease_progression ISO associated with Breast Neoplasms
associated with Cervix Neoplasms;mRNA:splice variant		 RGD PMID:17285241 PMID:17877643 RGD:2293098 RGD:2293103 NCBI chr 9:2,930,308...2,959,307 JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29426936 NCBI chr16:8,222,909...8,318,179
Ensembl chr16:8,222,907...8,317,906 		JBrowse link
G BRD7 bromodomain containing 7 severity ISO protein:increased expression:lung: RGD PMID:22008115 RGD:9586442 NCBI chr 2:64,966,636...65,002,800
Ensembl chr 2:64,966,392...65,002,799 		JBrowse link
G BSG basigin disease_progression ISO associated with Breast Neoplasms RGD PMID:16004819 RGD:2289055 NCBI chr20:57,942,703...57,951,089
Ensembl chr20:57,943,276...57,951,061 		JBrowse link
G BTK Bruton tyrosine kinase disease_progression ISO associated with lung adenocarcinoma;protein:increased expression:lung (human) RGD PMID:31200752 RGD:151347847 NCBI chr  X:75,270,952...75,302,663
Ensembl chr  X:75,270,979...75,302,562 		JBrowse link
G CA9 carbonic anhydrase 9 ISO associated with Cervix Neoplasms RGD PMID:17233814 RGD:2293196 NCBI chr11:52,205,619...52,211,281
Ensembl chr11:52,205,668...52,211,267 		JBrowse link
G CAB39 calcium binding protein 39 ISO associated with pancreatic cancer;RNA:increased expression:pancreas RGD PMID:28197410 RGD:14398834 NCBI chr25:42,752,798...42,801,257
Ensembl chr25:42,703,332...42,799,279 		JBrowse link
G CASP9 caspase 9 ISO associated with Carcinoma, Non-Small-Cell Lung;DNA:SNP:exon:rs1052576 (human) RGD PMID:17285546 RGD:13434907 NCBI chr 2:82,033,759...82,076,710
Ensembl chr 2:82,031,563...82,090,484 		JBrowse link
G CAV1 caveolin 1 disease_progression ISO associated with Melanoma RGD PMID:22134245 RGD:8661767 NCBI chr14:55,458,934...55,494,563
Ensembl chr14:55,461,048...55,492,935 		JBrowse link
G CBL Cbl proto-oncogene ISO associated with stomach carcinoma;protein:increased expression:stomach RGD PMID:31611438 RGD:126925223 NCBI chr 5:14,600,409...14,676,974
Ensembl chr 5:14,607,013...14,676,956 		JBrowse link
G CBLB Cbl proto-oncogene B ISO associated with stomach carcinoma; RGD PMID:20038312 RGD:150540338 NCBI chr33:11,255,453...11,665,755
Ensembl chr33:11,199,863...11,530,810 		JBrowse link
G CCND2 cyclin D2 ISO associated with colorectal cancer;protein:increased expression:colorectum RGD PMID:19508551 RGD:151665111 NCBI chr27:40,563,306...40,593,362
Ensembl chr27:40,564,921...40,594,255 		JBrowse link
G CCNE1 cyclin E1 ISO associated with Carcinoma, Transitional Cell;protein:decreased expression RGD PMID:16949911 RGD:2289266 NCBI chr 1:121,688,622...121,697,533
Ensembl chr 1:121,688,796...121,697,649 		JBrowse link
G CCNH cyclin H ISO CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr 3:21,046,477...21,067,305
Ensembl chr 3:21,046,472...21,178,315 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO associated with Breast Neoplasms;mRNA:increased expression:lymph node RGD PMID:24301790 RGD:8551816 NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952 		JBrowse link
G CD274 CD274 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:16530813 NCBI chr 1:93,461,735...93,605,772
Ensembl chr 1:93,585,518...93,603,522 		JBrowse link
G CD40 CD40 molecule ISO associated with breast cancer;DNA:snps:5' utr, intron:c.-1T>C, c.51+914T>G (rs1883832, rs4810485) (human) RGD PMID:21912605 RGD:8547780 NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301 		JBrowse link
G CD44 CD44 molecule ISO associated with Breast Neoplasms, Colorectal Neoplasms, Stomach Neoplasms;mRNA, protein:splice variant, increased expression:breast, large intestine, stomach RGD PMID:16425351 RGD:2289356 NCBI chr18:32,735,493...32,826,483
Ensembl chr18:32,737,907...32,827,107 		JBrowse link
G CDH1 cadherin 1 ISO associated with Breast Neoplasms
associated with Cervix Neoplasms		 RGD PMID:17649807 PMID:18097581 RGD:2289498 RGD:2296046 NCBI chr 5:80,757,508...80,834,878
Ensembl chr 5:80,757,508...80,834,878 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO associated with Eyelid Neoplasms;
associated with Oral Squamous Cell Carcinoma;		 RGD PMID:15817070 PMID:19628749 RGD:8661799 RGD:8662374 NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B ISO associated with Breast Neoplasms
associated with non-small cell lung carcinoma		 RGD PMID:12015771 PMID:28601655 RGD:13673921 RGD:2293607 NCBI chr27:33,609,154...33,613,558
Ensembl chr27:33,611,760...33,612,906 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:29426936 NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379 		JBrowse link
G CLDN1 claudin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33665778 NCBI chr34:22,303,058...22,319,101
Ensembl chr34:22,303,850...22,319,033 		JBrowse link
G CLPTM1L CLPTM1 like ISO associated with esophagus squamous cell carcinoma; mRNA:increased expression:esophagus RGD PMID:25480402 RGD:150530497 NCBI chr34:11,263,274...11,277,666
Ensembl chr34:11,263,162...11,277,436 		JBrowse link
G CLU clusterin ISO associated with breast cancer;DNA:snp:promoter:g.27611345C>G (rs9331888) (human) RGD PMID:22037783 RGD:8963167 NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563 		JBrowse link
G COMT catechol-O-methyltransferase ISO associated with breast cancer;DNA:missense mutation:cds:p.V108/158M (human) RGD PMID:10755383 RGD:8662330 NCBI chr26:29,359,930...29,381,854
Ensembl chr26:29,360,356...29,366,008 		JBrowse link
G CRP C-reactive protein susceptibility ISO associated with Breast Neoplasm; DNA:polymorphism: :1846C>T(rs1205)(human) RGD PMID:24633920 RGD:9580226 NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166 		JBrowse link
G CSF1R colony stimulating factor 1 receptor ISO associated with Breast Neoplasms RGD PMID:14734466 RGD:2293711 NCBI chr 4:58,980,699...59,010,683
Ensembl chr 4:58,980,788...59,010,510 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO associated with Prostatic Neoplasms RGD PMID:10611340 RGD:4891523 NCBI chr37:12,647,712...12,653,874
Ensembl chr37:12,634,563...12,653,874 		JBrowse link
G CTNNA1 catenin alpha 1 ISO associated with Breast Neoplasms RGD PMID:12047765 RGD:2289795 NCBI chr11:26,273,322...26,459,497
Ensembl chr11:26,143,013...26,459,091 		JBrowse link
G CTNNB1 catenin beta 1 ISO associated with Breast Neoplasms;protein:decreased expression RGD PMID:17908479 RGD:2289813 NCBI chr23:10,559,722...10,572,933
Ensembl chr23:10,559,718...10,572,927 		JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 disease_progression ISO associated with stomach cancer;mRNA:increased expression:stomach (human) RGD PMID:21633638 RGD:152023624 NCBI chr28:2,895,916...2,903,543 JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 ISO associated with nasopharynx carcinoma; protein:increased expression:lymph node (human) RGD PMID:16000558 RGD:151893515 NCBI chr19:38,874,650...38,877,740
Ensembl chr19:38,874,145...38,877,740 		JBrowse link
G CYCS cytochrome c, somatic ISO associated with non-small cell lung carcinoma; protein:decreased expression:serum RGD PMID:25578497 RGD:13792769 NCBI chr14:38,579,446...38,581,983
Ensembl chr14:38,579,446...38,581,983 		JBrowse link
G DDR1 discoidin domain receptor tyrosine kinase 1 severity ISO mRNA, protein:increased expression:mouth (human)
mRNA:increased expression:kidney, lymph nodes (human)		 RGD PMID:27020590 PMID:31253192 RGD:151347620 RGD:151347863 NCBI chr12:653,800...671,190
Ensembl chr12:653,807...670,543 		JBrowse link
G DDR2 discoidin domain receptor tyrosine kinase 2 disease_progression ISO associated with oral squamous cell carcinoma RGD PMID:29945346 RGD:150429700 NCBI chr38:20,002,984...20,152,930
Ensembl chr38:20,008,057...20,152,275 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta ISO associated with Carcinoma, Pancreatic Ductal; RGD PMID:22919364 RGD:9589121 NCBI chr24:22,096,386...22,123,378
Ensembl chr24:22,096,349...22,122,900 		JBrowse link
G EBAG9 estrogen receptor binding site associated antigen 9 ISO associated with Breast Neoplasms;protein:increased expression:breast
associated with Prostatic Neoplasm;protein:increased expression:prostate gland, lymph node		 RGD PMID:12054692 PMID:12845666 PMID:17187007 RGD:2289847 RGD:2289856 RGD:2298489 NCBI chr13:10,081,700...10,099,737
Ensembl chr13:10,081,695...10,099,501 		JBrowse link
G EGFR epidermal growth factor receptor treatment ISO associated with Squamous Cell Carcinoma of the Tongue RGD PMID:19380367 RGD:8551769 NCBI chr18:5,983,669...6,044,092
Ensembl chr18:5,982,770...6,042,631 		JBrowse link
G EHMT2 euchromatic histone lysine methyltransferase 2 ISO associated with Esophageal Squamous Cell Carcinoma;
associated with Melanoma;		 RGD PMID:24658378 PMID:24805087 RGD:9590069 RGD:9590071 NCBI chr12:1,341,202...1,354,602
Ensembl chr12:1,341,191...1,354,584 		JBrowse link
G EPHA2 EPH receptor A2 ISO protein:increased expression:esophagus (human) RGD PMID:33833989 RGD:153344568 NCBI chr 2:81,534,130...81,561,722
Ensembl chr 2:81,534,125...81,561,725 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 disease_progression ISO associated with Breast Neoplasms;DNA, protein:polymorphism, increased expression:serum:p.I655V
associated with Carcinoma, Transitional Cell;protein:increased expression:urinary bladder
CTD Direct Evidence: marker/mechanism
associated with lung adenocarcinoma; protein:increased expression:lung (human)		 RGD
CTD		 PMID:18097576 PMID:18237248 PMID:21532492 PMID:21966491 RGD:153344600 RGD:2289925 RGD:2289926 NCBI chr 9:22,760,373...22,785,367
Ensembl chr 9:22,759,256...22,785,294 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 ISO associated with Prostatic Neoplasms;protein:increased expression, altered localization:lymph node, nucleus
associated with head and neck squamous cell carcinoma		 RGD PMID:17634423 PMID:20604875 RGD:126790467 RGD:2289944 NCBI chr10:406,856...424,746
Ensembl chr10:406,633...424,264 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 severity
disease_progression		 ISO associated with oral squamous cell carcinoma
associated with colorectal adenocarcinoma
associated with lung non-small cell carcinoma		 RGD PMID:16507107 PMID:21324275 PMID:27444519 RGD:126781762 RGD:126781766 RGD:126790471 NCBI chr37:19,029,647...20,134,576
Ensembl chr37:19,037,217...20,134,426 		JBrowse link
G FAS Fas cell surface death receptor susceptibility ISO associated with Cervix Neoplasms;DNA:polymorphism:promoter:-1377G>A RGD PMID:18068525 RGD:2298509 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321 		JBrowse link
G FGF1 fibroblast growth factor 1 ISO associated with Cervix Neoplasms;mRNA:increased expression:lymph node RGD PMID:17242701 RGD:2290286 NCBI chr 2:37,467,431...37,554,770
Ensembl chr 2:37,470,985...37,554,619 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 ISO associated with breast cancer;DNA:snp:intron:c.109+7033T>A (rs1219648) (human) RGD PMID:20640597 RGD:7394846 NCBI chr28:31,303,882...31,411,015
Ensembl chr28:31,303,894...31,411,621 		JBrowse link
G FLT3 fms related receptor tyrosine kinase 3 disease_progression ISO associated with Prostatic Neoplasms RGD PMID:14566827 RGD:2302210 NCBI chr25:11,551,372...11,670,891
Ensembl chr25:11,581,206...11,692,284 		JBrowse link
G FOXA1 forkhead box A1 ISO associated with lung non-small cell carcinoma; mRNA:increased expression: : RGD PMID:29115441 RGD:151665751 NCBI chr 8:16,072,629...16,083,105
Ensembl chr 8:16,079,140...16,083,807 		JBrowse link
G FOXP1 forkhead box P1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25485836 NCBI chr20:20,438,631...21,020,516
Ensembl chr20:20,788,433...21,016,397 		JBrowse link
G GPX3 glutathione peroxidase 3 ISO associated with stomach carcinoma; DNA:hypermethylation:promoter RGD PMID:23071548 RGD:151665353 NCBI chr 4:58,200,671...58,209,010
Ensembl chr 4:58,200,672...58,209,010 		JBrowse link
G GRIK2 glutamate ionotropic receptor kainate type subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr12:58,932,754...59,991,305
Ensembl chr12:59,355,017...59,990,408 		JBrowse link
G HMGB1 high mobility group box 1 ISO associated with Adenocarcinoma, Colon RGD PMID:20616616 RGD:10402080 NCBI chr25:9,431,223...9,558,167
Ensembl chr25:9,431,218...9,558,165 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO associated with Breast Neoplasms RGD PMID:21590495 RGD:8547712 NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914 		JBrowse link
G IER2 immediate early response 2 ISO RGD PMID:22120713 RGD:153323322 NCBI chr20:49,071,243...49,074,184
Ensembl chr20:49,072,234...49,072,902 		JBrowse link
G IL13 interleukin 13 ISO associated with Melanoma, Cutaneous Malignant;mRNA:increased expression:lymph node RGD PMID:17545514 RGD:8549587 NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388 		JBrowse link
G IL18 interleukin 18 ISO associated with Breast Neoplasms;protein:increased expression:serum RGD PMID:12902898 RGD:8655867 NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348 		JBrowse link
G ING4 inhibitor of growth family member 4 ISO CTD Direct Evidence: therapeutic CTD PMID:27806345 NCBI chr27:38,371,656...38,379,251
Ensembl chr27:38,371,766...38,379,029 		JBrowse link
G IQSEC1 IQ motif and Sec7 domain ArfGEF 1 disease_progression ISO associated with lung adenocarcinoma; protein:increased expression:lung (human) RGD PMID:21966491 RGD:153344600 NCBI chr20:3,241,058...3,403,394
Ensembl chr20:3,241,052...3,522,859 		JBrowse link
G ITGB1 integrin subunit beta 1 ISO associated with non-small cell lung carcinoma, RGD PMID:28537888 RGD:13792830 NCBI chr 2:3,728,472...3,757,696
Ensembl chr 2:3,670,596...3,756,961 		JBrowse link
G KCNJ12 potassium inwardly rectifying channel subfamily J member 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34755307 NCBI chr 5:42,819,412...42,860,916
Ensembl chr 5:42,850,372...42,860,899 		JBrowse link
G KDR kinase insert domain receptor treatment ISO associated with Squamous Cell Carcinoma of the Tongue RGD PMID:19380367 RGD:8551769 NCBI chr13:47,442,861...47,484,574
Ensembl chr13:47,442,764...47,485,042 		JBrowse link
G KISS1 KiSS-1 metastasis suppressor ISO CTD Direct Evidence: therapeutic CTD PMID:21383688 NCBI chr38:768,333...774,328
Ensembl chr38:768,585...773,382 		JBrowse link
G KLF7 KLF transcription factor 7 ISO CTD Direct Evidence: therapeutic CTD PMID:37734194 NCBI chr37:15,515,563...15,607,345
Ensembl chr37:15,521,622...15,605,824 		JBrowse link
G KMT2D lysine methyltransferase 2D ISO associated with stomach cancer RGD PMID:30177394 RGD:150521710 NCBI chr27:5,516,866...5,556,303
Ensembl chr27:5,521,804...5,553,490 		JBrowse link
G LAMC2 laminin subunit gamma 2 ISO associated with lung squamous cell carcinoma; RGD PMID:23124251 RGD:13793371 NCBI chr 7:16,543,541...16,625,304
Ensembl chr 7:16,569,086...16,624,085 		JBrowse link
G LOC611363 mesothelin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22644300 NCBI chr 6:39,827,985...39,834,945 JBrowse link
G LRRC59 leucine rich repeat containing 59 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr 9:26,350,300...26,364,021
Ensembl chr 9:26,351,734...26,364,082 		JBrowse link
G MACIR macrophage immunometabolism regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr 3:7,956,865...7,968,964 JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29426936 NCBI chr14:55,599,047...55,711,626
Ensembl chr14:55,598,337...55,724,027 		JBrowse link
G MIR125A microRNA mir-125a ISO associated with stomach cancer; RGD PMID:22322911 RGD:21408544 NCBI chr 1:105,400,273...105,400,332
Ensembl chr 1:105,400,270...105,400,337 		JBrowse link
G MIR152 microRNA mir-152 ISO associated with breast cancer RGD PMID:22935141 RGD:19165152 NCBI chr 9:24,335,161...24,335,219
Ensembl chr 9:24,335,146...24,335,225 		JBrowse link
G MIR155 microRNA mir-155 disease_progression ISO associated with colon cancer RGD PMID:26885061 PMID:27856635 PMID:29893326 RGD:21079444 RGD:21079446 RGD:21409756 NCBI chr31:21,078,768...21,078,828
Ensembl chr31:21,078,758...21,078,833 		JBrowse link
G MIR187 microRNA mir-187 ISO associated with oral squamous cell carcinoma; RNA:increased expression:plasma RGD PMID:27542258 RGD:14390167 NCBI chr 7:54,261,943...54,262,010
Ensembl chr 7:54,261,943...54,262,010 		JBrowse link
G MIR224 microRNA mir-224 ISO associated with colorectal cancer; mRNA:decreased expression:colorectal mucosa: RGD PMID:25919696 RGD:14398749 NCBI chr  X:119,925,345...119,925,413
Ensembl chr  X:119,925,345...119,925,413 		JBrowse link
G MIR30A microRNA mir-30a ISO associated with Colorectal Neoplasms RGD PMID:23486085 RGD:13432035 NCBI chr12:33,783,894...33,783,956
Ensembl chr12:33,783,891...33,783,961 		JBrowse link
G MIR335 microRNA mir-335 ISO associated with stomach cancer; RNA:decreased expression:stomach RGD PMID:21822301 RGD:14394425 NCBI chr14:6,444,861...6,444,918
Ensembl chr14:6,444,847...6,444,932 		JBrowse link
G MIR432 microRNA mir-432 disease_progression ISO mRNA:decreased expression:colon (human) RGD PMID:33717244 RGD:152999433 NCBI chr 8:69,106,415...69,106,501
Ensembl chr 8:69,106,415...69,106,501 		JBrowse link
G MMP2 matrix metallopeptidase 2 disease_progression ISO associated with Carcinoma, Ductal, Breast
associated with Tongue Neoplasms		 RGD PMID:23107277 PMID:23280016 RGD:8547824 RGD:8655998 NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113 		JBrowse link
G MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) ISO associated with breast cancer;DNA:deletion:promoter:-1170_-1172delA (human) RGD PMID:15161710 RGD:8662937 NCBI chr 5:28,949,631...28,957,915
Ensembl chr 5:28,949,631...28,958,222 		JBrowse link
G MMP9 matrix metallopeptidase 9 disease_progression ISO associated with Endometrial Neoplasms;protein:increased expression:endometrium
associated with Carcinoma, Non-Small-Cell Lung;protein:increased expression:serum
associated with Tongue Neoplasms		 RGD PMID:12487935 PMID:20704821 PMID:23107277 RGD:2298523 RGD:5129215 RGD:8547824 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293 		JBrowse link
G MSH2 mutS homolog 2 ISO associated with laryngeal squamous cell carcinoma RGD PMID:24459922 RGD:126848797 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210 		JBrowse link
G MTA1 metastasis associated 1 ISO associated with Carcinoma, Non-Small-Cell Lung;mRNA:increased expression:lung RGD PMID:11804687 RGD:9588220 NCBI chr 8:72,752,894...72,772,236
Ensembl chr 8:72,753,178...72,772,762 		JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr 2:84,818,893...84,939,283
Ensembl chr 2:84,787,708...84,939,114 		JBrowse link
G MUC1 mucin 1, cell surface associated ISO associated with Common Bile Duct Neoplasms
associated with Carcinoma, Renal Cell;
associated with Gallbladder Neoplasms;protein:altered localization:gallbladder
associated with Esophageal Neoplasms		 RGD PMID:10390012 PMID:11295067 PMID:16222735 PMID:21339746 RGD:2324649 RGD:2324860 RGD:7245968 RGD:7349383 NCBI chr 7:42,338,939...42,344,690
Ensembl chr 7:42,340,375...42,344,690 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming ISO associated with chloangiocarcinoma;protein:increased expression:bile duct RGD PMID:16842244 RGD:2325168 NCBI chr18:45,471,232...45,498,961 JBrowse link
G NCAM1 neural cell adhesion molecule 1 ISO RGD PMID:10086383 RGD:2326067 NCBI chr 5:19,895,587...20,192,334
Ensembl chr 5:19,895,613...20,191,995 		JBrowse link
G NME1 non-metastatic cells 1, protein (NM23A) expressed in ISO associated with Cervix Neoplasms; associated with Endometrial Neoplasms
associated with Breast Neoplasms		 RGD PMID:8102131 PMID:8855975 PMID:9036878 RGD:2299061 RGD:2299062 RGD:2299077 NCBI chr 9:26,990,336...26,998,895
Ensembl chr 9:26,990,469...26,998,955 		JBrowse link
G NME2 non-metastatic cells 2, protein (NM23B) expressed in ISO associated with Cervix Neoplasms; associated with Endometrial Neoplasms RGD PMID:8855975 RGD:2299062 NCBI chr 9:27,002,114...27,005,740
Ensembl chr 9:27,001,733...27,015,934 		JBrowse link
G NOS3 nitric oxide synthase 3 susceptibility ISO associated with Breast Neoplasms;DNA:polymorphisms:promoter, exon:-786T>C,p.E298D (human) RGD PMID:17262178 RGD:2292070 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277 		JBrowse link
G OGG1 8-oxoguanine DNA glycosylase ISO associated with breast cancer;DNA:missense mutation:cds:p.S326C (rs1052133) (human) RGD PMID:18977234 RGD:8657156 NCBI chr20:8,486,150...8,491,448
Ensembl chr20:8,480,005...8,491,264 		JBrowse link
G PAGR1 PAXIP1 associated glutamate rich protein 1 disease_progression ISO protein:decreased expression:esophagus (human) RGD PMID:33833989 RGD:153344568 NCBI chr 6:17,876,740...17,879,546 JBrowse link
G PDGFA platelet derived growth factor subunit A ISO associated with Breast Neoplasms;mRNA:increased expression:breast RGD PMID:8619189 RGD:2292155 NCBI chr 6:16,271,082...16,293,246
Ensembl chr 6:16,270,104...16,292,396 		JBrowse link
G PDGFB platelet derived growth factor subunit B ISO associated with Breast Neoplasms;mRNA:increased expression:lymph node RGD PMID:17674348 RGD:2292173 NCBI chr10:25,798,877...25,819,422
Ensembl chr10:25,798,938...25,817,746 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO associated with non-small cell lung carcinoma;mRNA:increased expression:blood serum RGD PMID:25064732 RGD:13503320 NCBI chr 6:38,426,464...38,506,520
Ensembl chr 6:38,431,600...38,499,295 		JBrowse link
G PDPN podoplanin ISO associated with Breast Neoplasms
associated with Cervix Neoplasms		 RGD PMID:16528371 PMID:18165897 RGD:2292231 RGD:2292237 NCBI chr 2:83,552,735...83,581,375
Ensembl chr 2:83,552,830...83,581,375 		JBrowse link
G PEBP1 phosphatidylethanolamine binding protein 1 ISO associated with Cervix Neoplasms
associated with Breast Neoplasms		 RGD PMID:16243812 PMID:18191186 RGD:2302867 RGD:2302868 NCBI chr26:14,522,124...14,526,370
Ensembl chr26:14,500,074...14,529,354 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO associated with Colorectal Neoplasms RGD PMID:25550888 RGD:13432030 NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910 		JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta ISO associated with Colorectal Neoplasms RGD PMID:25550888 RGD:13432030 NCBI chr23:34,832,661...34,955,410
Ensembl chr23:34,836,540...34,993,939 		JBrowse link
G PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:34755307 NCBI chr17:60,257,017...60,295,866
Ensembl chr17:60,257,332...60,295,866 		JBrowse link
G POU5F1 POU class 5 homeobox 1 ISO associated with Seminoma; associated with Carcinoma, Embryonal RGD PMID:15386301 RGD:2292442
G PPARG peroxisome proliferator activated receptor gamma ISO associated with Cholangiocarcinoma;protein:increased expression:bile duct epithelium RGD PMID:20021832 RGD:2317459 NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981 		JBrowse link
G PREX1 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 ISO associated with Prostatic Neoplasms RGD PMID:19305425 RGD:2314605 NCBI chr24:35,403,078...35,503,428
Ensembl chr24:35,404,564...35,582,041 		JBrowse link
G PTEN phosphatase and tensin homolog ISO associated with Breast Neoplasms
associated with Prostatic Neoplasms;protein:decreased expression:prostate		 RGD PMID:17163422 PMID:17919877 RGD:2292499 RGD:2292507 NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO associated with Breast Neoplasms
associated with carcinoma, non-small-cell lung; DNA:SNP: :929G>C(human)
associated with Biliary Tract Neoplasms		 RGD PMID:18159174 PMID:18353210 PMID:20016751 RGD:2300128 RGD:2317165 RGD:5135471 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903 		JBrowse link
G PTK2 protein tyrosine kinase 2 ISO associated with lung squamous cell carcinoma; protein:increased tyrosine phosphorylation:lymph node RGD PMID:23906871 RGD:152176664 NCBI chr13:35,302,439...35,541,336
Ensembl chr13:35,303,380...35,541,294 		JBrowse link
G PTPN13 protein tyrosine phosphatase non-receptor type 13 ISO associated with lung squamous cell carcinoma; protein:decreased expression:lymph node RGD PMID:23906871 RGD:152176664 NCBI chr32:10,125,447...10,328,764
Ensembl chr32:10,125,441...10,328,757 		JBrowse link
G RAMP2 receptor activity modifying protein 2 disease_progression ISO associated with colorectal cancer; protein:increased expression:lymph node (human) RGD PMID:23634287 RGD:151708733 NCBI chr 9:20,250,711...20,252,485 JBrowse link
G RAMP3 receptor activity modifying protein 3 ISO associated with colorectal cancer; protein:increased expression:lymph node (human) RGD PMID:23634287 RGD:151708733
G RASSF2 Ras association domain family member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17013896 NCBI chr24:16,736,786...16,779,910
Ensembl chr24:16,736,962...16,781,569 		JBrowse link
G RBM10 RNA binding motif protein 10 ISO associated with lung adenocarcinoma;DNA:missense mutation:exon:p.R241C (c.763C>T) (human) RGD PMID:30405763 RGD:151356993 NCBI chr  X:40,746,959...40,776,764
Ensembl chr  X:40,747,178...40,776,742 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO associated with Prostatic Neoplasms;protein:altered localization:nucleus, prostate gland RGD PMID:17020979 RGD:2298757 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875 		JBrowse link
G RET ret proto-oncogene ISO associated with Pancreatic Neoplasms RGD PMID:18652760 RGD:2324925 NCBI chr28:3,946,132...3,995,505
Ensembl chr28:3,947,232...3,994,210 		JBrowse link
G RHOA ras homolog family member A ISO associated with Bladder Neoplasms;protein:increased expression:lymph node
associated with colorectal cancer		 RGD PMID:12855641 PMID:17597401 RGD:13432052 RGD:2298872 NCBI chr20:39,824,552...39,888,089
Ensembl chr20:39,824,575...39,887,215 		JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 ISO associated with breast ductal carcinoma; protein:increased expression:breast tumor, lymph node (human) RGD PMID:20978191 RGD:152995469 NCBI chr 4:69,903,393...70,013,168
Ensembl chr 4:69,936,379...70,010,566 		JBrowse link
G RUNX1 RUNX family transcription factor 1 ISO associated with Carcinoid Tumor RGD PMID:21636701 RGD:126779567 NCBI chr31:30,170,859...30,420,344
Ensembl chr31:30,170,605...30,420,839 		JBrowse link
G SFN stratifin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 2:73,268,289...73,269,663
Ensembl chr 2:73,268,791...73,269,537 		JBrowse link
G SKP2 S-phase kinase associated protein 2 ISO associated with Endometrial Neoplasms;protein:increased expression:endometrium RGD PMID:16080017 RGD:2315043 NCBI chr 4:72,352,966...72,386,469
Ensembl chr 4:72,352,986...72,386,307 		JBrowse link
G SLC22A10 solute carrier family 22 member 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr18:53,597,148...53,628,569
Ensembl chr18:53,597,533...53,628,165 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 severity ISO associated with gastric adenocarcinoma;protein:increased expression: :
associated with stomach carcinoma		 RGD PMID:21501294 PMID:25908107 RGD:11052781 RGD:151361203 NCBI chr 5:65,313,105...65,343,858
Ensembl chr 5:65,313,105...65,343,858 		JBrowse link
G SMAD4 SMAD family member 4 ISO associated with Breast Neoplasms RGD PMID:11809701 RGD:2300007 NCBI chr 1:23,875,989...23,930,027
Ensembl chr 1:23,882,139...23,969,405 		JBrowse link
G SMO smoothened, frizzled class receptor ISO associated with colorectal cancer RGD PMID:30784110 RGD:150520177 NCBI chr14:7,518,871...7,527,703
Ensembl chr14:7,518,856...7,528,033 		JBrowse link
G SNCG synuclein gamma ISO RGD PMID:15221989 RGD:6478801 NCBI chr 4:34,604,867...34,608,851
Ensembl chr 4:34,605,091...34,608,842 		JBrowse link
G SOCS2 suppressor of cytokine signaling 2 ISO associated with Prostatic Neoplasms RGD PMID:16707422 RGD:2298925 NCBI chr15:33,761,434...33,788,973
Ensembl chr15:33,785,545...33,877,869 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 ISO associated with Breast Neoplasms RGD PMID:18097573 RGD:2298901 NCBI chr 9:2,859,267...2,859,944 JBrowse link
G SOD2 superoxide dismutase 2 disease_progression ISO CTD Direct Evidence: marker/mechanism
associated with tongue neoplasms;		 CTD
RGD		 PMID:10853026 PMID:19381893 PMID:20618948 RGD:8547519 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706 		JBrowse link
G SOX2 SRY-box transcription factor 2 disease_progression ISO associated with Breast Neoplasms RGD PMID:24382260 RGD:8661670 NCBI chr34:14,853,000...14,855,153 JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO associated with colon adenocarcinoma, RGD PMID:21282564 RGD:150520218 NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077 		JBrowse link
G ST14 ST14 transmembrane serine protease matriptase ISO associated with Endometrial Neoplasms RGD PMID:19443387 RGD:2315087 NCBI chr 5:4,652,493...4,666,728
Ensembl chr 5:4,651,863...4,691,069 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21549414 NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672 		JBrowse link
G STK11 serine/threonine kinase 11 ISO associated with Breast Neoplasms;protein:decreased expression RGD PMID:12114407 RGD:2291948 NCBI chr20:57,558,966...57,579,163
Ensembl chr20:57,559,424...57,579,118 		JBrowse link
G TERT telomerase reverse transcriptase disease_progression ISO associated with lung non-small cell carcinoma; RGD PMID:11679180 RGD:152977755 NCBI chr34:11,288,622...11,307,790
Ensembl chr34:11,288,622...11,307,951 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 ISO associated with Endometrial Neoplasms;protein:increased expression:endometrium RGD PMID:12487935 RGD:2298523 NCBI chr  X:41,201,623...41,205,314
Ensembl chr  X:41,201,638...41,205,310 		JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 ISO associated with Breast Neoplasms;mRNA:increased expression:breast RGD PMID:12828172 RGD:2290437 NCBI chr10:30,627,154...30,681,520
Ensembl chr10:30,627,154...30,694,288 		JBrowse link
G TIMP4 TIMP metallopeptidase inhibitor 4 ISO associated with Breast Neoplasms;mRNA:increased expression:breast RGD PMID:12828172 RGD:2290437 NCBI chr20:6,399,522...6,405,089
Ensembl chr20:6,399,522...6,405,089 		JBrowse link
G TLR4 toll like receptor 4 ISO associated with Carcinoma, Ductal, Breast; RGD PMID:23338716 RGD:7794684 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165 		JBrowse link
G TP53 tumor protein p53 ISO associated with Breast Neoplasms;DNA:missense mutation, duplication:cds, intron:p.R72P
associated with Carcinoma, Squamous Cell;
associated with Penile Neoplasms		 RGD PMID:18059331 PMID:18230179 PMID:18268397 RGD:2290533 RGD:2290534 RGD:8547790 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr30:10,263,650...10,362,646
Ensembl chr30:10,263,650...10,336,134 		JBrowse link
G TRMT11 tRNA methyltransferase 11 homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr 1:64,861,404...64,917,449
Ensembl chr 1:64,834,770...65,064,562 		JBrowse link
G TSC2 TSC complex subunit 2 ISO associated with Breast Neoplasms RGD PMID:15951164 RGD:11568707 NCBI chr 6:38,865,509...38,898,977
Ensembl chr 6:38,865,507...38,898,960 		JBrowse link
G TSHR thyroid stimulating hormone receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9062474 NCBI chr 8:53,327,280...53,482,898
Ensembl chr 8:53,326,655...53,482,898 		JBrowse link
G TTR transthyretin ISO associated with colorectal cancer;protein:decreased expresion:blood serum (human) RGD PMID:21074777 RGD:151665155 NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO associated with Breast neoplasms;
associated with Cervix Neoplasms		 RGD PMID:17597103 PMID:19783962 RGD:2315454 RGD:7421574 NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965 		JBrowse link
G VEGFC vascular endothelial growth factor C disease_progression
exacerbates		 ISO associated with Lymphatic Metastasis;
associated with Cervix Neoplasms
associated with thyroid diseases;mRNA:increased expression:thyroid gland:
associated with Prostatic Neoplasms
associated with Carcinoma, Transitional Cell;protein:increased expression:urinary bladder
associated with Breast Neoplasms
associated with pancreatic adenocarcinoma;protein:increased expression:pancreas (human)		 RGD PMID:12203051 PMID:15289890 PMID:17034609 PMID:18061373 PMID:19589137 More... RGD:155630642 RGD:2315469 RGD:2315474 RGD:2315475 RGD:2315484 RGD:7483611 RGD:7488946 NCBI chr16:52,883,242...52,987,684
Ensembl chr16:52,883,139...52,987,563 		JBrowse link
G VEGFD vascular endothelial growth factor D ISO associated with Breast Neoplasms
associated with Cervix Neoplasms		 RGD PMID:17951197 PMID:19589137 RGD:2315475 RGD:2315480 NCBI chr  X:11,590,097...11,627,199
Ensembl chr  X:11,590,089...11,626,486 		JBrowse link
G WRAP53 WD repeat containing antisense to TP53 ISO associated with esophagus squamous cell carcinoma;
associated with lung non-small cell carcinoma;		 RGD PMID:24626331 PMID:31281482 RGD:21081513 RGD:21081532 NCBI chr 5:32,574,153...32,586,222
Ensembl chr 5:32,574,134...32,594,333 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15674
    disease of anatomical entity 15315
      immune system disease 4499
        lymphatic system disease 1685
          Lymphatic Metastasis 161
Path 2
Term Annotations click to browse term
  disease 15674
    disease of anatomical entity 15315
      Immune & Inflammatory Diseases 5190
        immune system disease 4499
          lymphatic system disease 1685
            Lymphatic Metastasis 161
paths to the root