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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:fascioliasis
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Accession:DOID:885 term browser browse the term
Definition:A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa. (DO)
Synonyms:exact_synonym: Fasciola hepatica infection;   Fascioliases;   infection by Fasciola;   liver flukes;   sheep liver fluke infection
 primary_id: MESH:D005211
 xref: EFO:1001324;   GARD:6428;   ICD10CM:B66.3;   ICD9CM:121.3;   NCI:C128387
For additional species annotation, visit the Alliance of Genome Resources.


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fascioliasis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsb cathepsin B IEP protein:decreased activity:liver (rat) RGD PMID:19696938 RGD:2315504 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Glud1 glutamate dehydrogenase 1 IEP protein:increased expression:serum RGD PMID:10431747 RGD:6484593 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19100
    disease by infectious agent 2253
      parasitic infectious disease 328
        Parasitic Liver Diseases 24
          fascioliasis 2
Path 2
Term Annotations click to browse term
  disease 19100
    disease of anatomical entity 18440
      gastrointestinal system disease 7176
        hepatobiliary disease 3116
          biliary tract disease 542
            bile duct disease 498
              fascioliasis 2
paths to the root