RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: perinatal necrotizing enterocolitis
Accession: DOID:8677
browse the term
Definition: ENTEROCOLITIS with extensive ulceration (ULCER) and NECROSIS. It is observed primarily in LOW BIRTH WEIGHT INFANT.
Synonyms: exact_synonym: NEC; necrotizing enterocolitis; necrotizing enterocolitis in fetus or newborn; perinatal necrotising enterocolitis; pseudomembranous enterocolitis in newborn
primary_id: MESH:D020345
xref: EFO:0003928 ; ICD10CM:K55.3 ; ICD10CM:K55.30
For additional species annotation, visit the
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Abcb1
ATP binding cassette subfamily B member 1
susceptibility
ISO
RGD
PMID:21788941
RGD:8657143
NCBI chrNW_004955432:4,911,774...5,085,349
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Acadm
acyl-CoA dehydrogenase medium chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18806098
NCBI chrNW_004955423:17,173,648...17,199,189
Ensembl chrNW_004955423:17,172,779...17,199,090
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Akr1a1
aldo-keto reductase family 1 member A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18806098
NCBI chrNW_004955464:12,715,238...12,729,034
Ensembl chrNW_004955464:12,714,717...12,729,662
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Aldh2
aldehyde dehydrogenase 2 family member
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18806098
NCBI chrNW_004955482:8,352,569...8,383,097
Ensembl chrNW_004955482:8,352,569...8,384,899
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Becn1
beclin 1
ISO
protein:increased expression:intestine
RGD
PMID:20539009
RGD:6483081
NCBI chrNW_004955451:16,616,595...16,625,731
Ensembl chrNW_004955451:16,616,595...16,625,730
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Bnip3
BCL2 interacting protein 3
ISO
protein:increased expression:ileum
RGD
PMID:16002567
RGD:11561971
NCBI chrNW_004955477:9,621,812...9,630,406
Ensembl chrNW_004955477:9,621,812...9,638,099
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Cd14
CD14 molecule
disease_progression
ISO
protein:increased expression:small intestine
RGD
PMID:19824106
RGD:4144091
NCBI chrNW_004955418:73,736...75,345
Ensembl chrNW_004955418:73,897...75,224
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Cd40
CD40 molecule
ISO
protein:decreased expression:ileum
RGD
PMID:21240009
RGD:5490305
NCBI chrNW_004955445:11,191,817...11,202,156
Ensembl chrNW_004955445:11,190,603...11,202,093
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Cd40lg
CD40 ligand
ISO
protein:decreased expression:ileum
RGD
PMID:21240009
RGD:5490305
NCBI chrNW_004955489:8,465,571...8,477,714
Ensembl chrNW_004955489:8,465,164...8,477,746
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Cryl1
crystallin lambda 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18806098
NCBI chrNW_004955497:1,183,707...1,316,720
Ensembl chrNW_004955497:1,182,115...1,292,721
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Egf
epidermal growth factor
treatment
ISO
RGD
PMID:18607263 PMID:19390485
RGD:10395236 RGD:2317627
NCBI chrNW_004955496:325,954...401,430
Ensembl chrNW_004955496:328,075...401,569
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Eno1
enolase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18806098
NCBI chrNW_004955486:4,275,371...4,287,152
Ensembl chrNW_004955486:4,274,238...4,289,809
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Hbegf
heparin binding EGF like growth factor
treatment
ISO
CTD Direct Evidence: therapeutic
RGD CTD
PMID:16567187 PMID:18607263
RGD:10395236
NCBI chrNW_004955418:259,860...321,340
Ensembl chrNW_004955418:309,096...321,387
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Hspa9
heat shock protein family A (Hsp70) member 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18806098
NCBI chrNW_004955418:1,915,985...1,931,017
Ensembl chrNW_004955418:1,915,985...1,931,017
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Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
treatment
ISO
RGD
PMID:17426653
RGD:12791281
NCBI chrNW_004955580:1,053,823...1,069,802
Ensembl chrNW_004955580:1,053,823...1,069,802
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Il10
interleukin 10
treatment
ISO
RGD
PMID:22450025 PMID:23783008
RGD:11049491 RGD:7365018
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
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Il10rb
interleukin 10 receptor subunit beta
ISO
protein:increased expression:ileum
RGD
PMID:21240009
RGD:5490305
NCBI chrNW_004955407:32,641,097...32,659,360
Ensembl chrNW_004955407:32,640,622...32,663,259
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Il18
interleukin 18
ISO
protein:increased expression:ileum protein:increased expression:liver
RGD
PMID:12032269 PMID:12529262 PMID:17947451 PMID:21240009
RGD:4889473 RGD:4889475 RGD:5490305 RGD:729222
NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
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Il1b
interleukin 1 beta
ISO
RGD
PMID:23158403
RGD:7175550
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il6
interleukin 6
treatment
ISO
RGD
PMID:20501441
RGD:2324672
NCBI chrNW_004955410:25,079,835...25,084,390
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Lgals2
galectin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18806098
NCBI chrNW_004955413:23,988,193...24,001,868
Ensembl chrNW_004955413:23,988,193...23,989,703
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Ltf
lactotransferrin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16640825
NCBI chrNW_004955420:25,580,449...25,604,277
Ensembl chrNW_004955420:25,580,359...25,604,331
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Map3k5
mitogen-activated protein kinase kinase kinase 5
ISO
protein:increased expression:intestine:
RGD
PMID:20716917
RGD:10412640
NCBI chrNW_004955439:162,499...376,919
Ensembl chrNW_004955439:163,103...377,808
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Muc2
mucin 2, oligomeric mucus/gel-forming
ISO
mRNA:decreased expression:ileum
RGD
PMID:20501441
RGD:2324672
NCBI chrNW_004955476:11,108,826...11,135,697
Ensembl chrNW_004955476:11,108,826...11,135,697
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Nod2
nucleotide binding oligomerization domain containing 2
ISO
RGD
PMID:20580721
RGD:8547529
NCBI chrNW_004955433:8,746,213...8,780,119
Ensembl chrNW_004955433:8,746,004...8,782,710
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Nos2
nitric oxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17923197
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Nos3
nitric oxide synthase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23650378
NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814
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Oat
ornithine aminotransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18806098
NCBI chrNW_004955477:2,430,146...2,450,135
Ensembl chrNW_004955477:2,429,776...2,450,624
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Park7
Parkinsonism associated deglycase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18806098
NCBI chrNW_004955486:4,974,130...4,985,927
Ensembl chrNW_004955486:4,969,497...4,985,885
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Parp1
poly(ADP-ribose) polymerase 1
severity
ISO
protein:increased expression:intestinal mucosa
RGD
PMID:21399558
RGD:10413911
NCBI chrNW_004955489:520,875...557,609
Ensembl chrNW_004955489:520,875...557,615
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Plaur
plasminogen activator, urokinase receptor
ISO
protein:increased expression:plasma
RGD
PMID:1304722
RGD:6483787
NCBI chrNW_004955555:1,378,505...1,393,395
Ensembl chrNW_004955555:1,378,793...1,393,324
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Ptafr
platelet activating factor receptor
treatment
ISO
RGD
PMID:17515866
RGD:9999208
NCBI chrNW_004955452:7,309,854...7,345,579
Ensembl chrNW_004955452:7,311,901...7,312,929
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Snai3
snail family transcriptional repressor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18806098
NCBI chrNW_004955541:2,593,530...2,599,105
Ensembl chrNW_004955541:2,593,351...2,599,175
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Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18806098
NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163
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Sord
sorbitol dehydrogenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18806098
NCBI chrNW_004955409:8,305,819...8,333,733
Ensembl chrNW_004955409:8,303,602...8,333,869
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Tjp1
tight junction protein 1
ISO
protein:increased expression:liver
RGD
PMID:19390485
RGD:2317627
NCBI chrNW_004955416:28,640,807...28,869,717
Ensembl chrNW_004955416:28,654,905...28,870,555
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Tlr1
toll like receptor 1
ISO
mRNA:increased expression:ileum
RGD
PMID:19608731
RGD:5128779
NCBI chrNW_004955443:8,442,419...8,450,318
Ensembl chrNW_004955443:8,447,956...8,450,382
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Tlr2
toll like receptor 2
ISO
mRNA:increased expression:ileum
RGD
PMID:19608731
RGD:5128779
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tlr3
toll like receptor 3
ISO
mRNA:increased expression:ileum (rat)
RGD
PMID:19608731
RGD:5128779
NCBI chrNW_004955403:22,977,882...23,001,392
Ensembl chrNW_004955403:22,979,120...23,001,467
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Tlr4
toll like receptor 4
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:ileum mRNA:increased expression:ileum
CTD RGD
PMID:19608731 PMID:21240009 PMID:23650378
RGD:5128779 RGD:5490305
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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Tlr5
toll like receptor 5
ISO
mRNA:decreased expression:ileum (rat)
RGD
PMID:19608731
RGD:5128779
NCBI chrNW_004955520:1,544,840...1,562,081
Ensembl chrNW_004955520:1,556,523...1,559,093
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Tlr6
toll like receptor 6
ISO
mRNA:increased expression:ileum
RGD
PMID:19608731
RGD:5128779
NCBI chrNW_004955443:8,401,461...8,427,175
Ensembl chrNW_004955443:8,422,534...8,424,942
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Tlr7
toll like receptor 7
ISO
mRNA:increased expression:ileum
RGD
PMID:19608731
RGD:5128779
NCBI chrNW_004955544:424,897...443,562
Ensembl chrNW_004955544:424,850...443,564
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Tlr9
toll like receptor 9
ISO
mRNA:increased expression:ileum (rat)
RGD
PMID:19608731
RGD:5128779
NCBI chrNW_004955532:3,828,645...3,832,699
Ensembl chrNW_004955532:3,828,775...3,832,582
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Tnf
tumor necrosis factor
ISO
protein:increased expression:intestine protein:increased expression:serum mRNA:increased expression:ileum (rat)
RGD
PMID:16269520 PMID:19824106 PMID:20501441
RGD:1580205 RGD:2324672 RGD:4144091
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Tubb
tubulin beta class I
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18806098
NCBI chrNW_004955583:704,811...715,742
Ensembl chrNW_004955583:704,750...718,649
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