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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:perinatal necrotizing enterocolitis
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Accession:DOID:8677 term browser browse the term
Definition:ENTEROCOLITIS with extensive ulceration (ULCER) and NECROSIS. It is observed primarily in LOW BIRTH WEIGHT INFANT.
Synonyms:exact_synonym: NEC;   necrotizing enterocolitis;   necrotizing enterocolitis in fetus or newborn;   perinatal necrotising enterocolitis;   pseudomembranous enterocolitis in newborn
 primary_id: MESH:D020345
 xref: EFO:0003928;   ICD10CM:K55.3;   ICD10CM:K55.30
For additional species annotation, visit the Alliance of Genome Resources.


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perinatal necrotizing enterocolitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1 ATP binding cassette subfamily B member 1 susceptibility ISO RGD PMID:21788941 RGD:8657143 NCBI chrNW_004955432:4,911,774...5,085,349 JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chrNW_004955423:17,173,648...17,199,189
Ensembl chrNW_004955423:17,172,779...17,199,090
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chrNW_004955464:12,715,238...12,729,034
Ensembl chrNW_004955464:12,714,717...12,729,662
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chrNW_004955482:8,352,569...8,383,097
Ensembl chrNW_004955482:8,352,569...8,384,899
JBrowse link
G Becn1 beclin 1 ISO protein:increased expression:intestine RGD PMID:20539009 RGD:6483081 NCBI chrNW_004955451:16,616,595...16,625,731
Ensembl chrNW_004955451:16,616,595...16,625,730
JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO protein:increased expression:ileum RGD PMID:16002567 RGD:11561971 NCBI chrNW_004955477:9,621,812...9,630,406
Ensembl chrNW_004955477:9,621,812...9,638,099
JBrowse link
G Cd14 CD14 molecule disease_progression ISO protein:increased expression:small intestine RGD PMID:19824106 RGD:4144091 NCBI chrNW_004955418:73,736...75,345
Ensembl chrNW_004955418:73,897...75,224
JBrowse link
G Cd40 CD40 molecule ISO protein:decreased expression:ileum RGD PMID:21240009 RGD:5490305 NCBI chrNW_004955445:11,191,817...11,202,156
Ensembl chrNW_004955445:11,190,603...11,202,093
JBrowse link
G Cd40lg CD40 ligand ISO protein:decreased expression:ileum RGD PMID:21240009 RGD:5490305 NCBI chrNW_004955489:8,465,571...8,477,714
Ensembl chrNW_004955489:8,465,164...8,477,746
JBrowse link
G Cryl1 crystallin lambda 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chrNW_004955497:1,183,707...1,316,720
Ensembl chrNW_004955497:1,182,115...1,292,721
JBrowse link
G Egf epidermal growth factor treatment ISO RGD PMID:18607263 PMID:19390485 RGD:10395236 RGD:2317627 NCBI chrNW_004955496:325,954...401,430
Ensembl chrNW_004955496:328,075...401,569
JBrowse link
G Eno1 enolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chrNW_004955486:4,275,371...4,287,152
Ensembl chrNW_004955486:4,274,238...4,289,809
JBrowse link
G Hbegf heparin binding EGF like growth factor treatment ISO CTD Direct Evidence: therapeutic RGD
CTD
PMID:16567187 PMID:18607263 RGD:10395236 NCBI chrNW_004955418:259,860...321,340
Ensembl chrNW_004955418:309,096...321,387
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chrNW_004955418:1,915,985...1,931,017
Ensembl chrNW_004955418:1,915,985...1,931,017
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma treatment ISO RGD PMID:17426653 RGD:12791281 NCBI chrNW_004955580:1,053,823...1,069,802
Ensembl chrNW_004955580:1,053,823...1,069,802
JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:22450025 PMID:23783008 RGD:11049491 RGD:7365018 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
JBrowse link
G Il10rb interleukin 10 receptor subunit beta ISO protein:increased expression:ileum RGD PMID:21240009 RGD:5490305 NCBI chrNW_004955407:32,641,097...32,659,360
Ensembl chrNW_004955407:32,640,622...32,663,259
JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:ileum
protein:increased expression:liver
RGD PMID:12032269 PMID:12529262 PMID:17947451 PMID:21240009 RGD:4889473 RGD:4889475 RGD:5490305 RGD:729222 NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:23158403 RGD:7175550 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
JBrowse link
G Il6 interleukin 6 treatment ISO RGD PMID:20501441 RGD:2324672 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Lgals2 galectin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chrNW_004955413:23,988,193...24,001,868
Ensembl chrNW_004955413:23,988,193...23,989,703
JBrowse link
G Ltf lactotransferrin ISO CTD Direct Evidence: therapeutic CTD PMID:16640825 NCBI chrNW_004955420:25,580,449...25,604,277
Ensembl chrNW_004955420:25,580,359...25,604,331
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO protein:increased expression:intestine: RGD PMID:20716917 RGD:10412640 NCBI chrNW_004955439:162,499...376,919
Ensembl chrNW_004955439:163,103...377,808
JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming ISO mRNA:decreased expression:ileum RGD PMID:20501441 RGD:2324672 NCBI chrNW_004955476:11,108,826...11,135,697
Ensembl chrNW_004955476:11,108,826...11,135,697
JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 ISO RGD PMID:20580721 RGD:8547529 NCBI chrNW_004955433:8,746,213...8,780,119
Ensembl chrNW_004955433:8,746,004...8,782,710
JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17923197 NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
JBrowse link
G Nos3 nitric oxide synthase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23650378 NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814
JBrowse link
G Oat ornithine aminotransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chrNW_004955477:2,430,146...2,450,135
Ensembl chrNW_004955477:2,429,776...2,450,624
JBrowse link
G Park7 Parkinsonism associated deglycase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chrNW_004955486:4,974,130...4,985,927
Ensembl chrNW_004955486:4,969,497...4,985,885
JBrowse link
G Parp1 poly(ADP-ribose) polymerase 1 severity ISO protein:increased expression:intestinal mucosa RGD PMID:21399558 RGD:10413911 NCBI chrNW_004955489:520,875...557,609
Ensembl chrNW_004955489:520,875...557,615
JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO protein:increased expression:plasma RGD PMID:1304722 RGD:6483787 NCBI chrNW_004955555:1,378,505...1,393,395
Ensembl chrNW_004955555:1,378,793...1,393,324
JBrowse link
G Ptafr platelet activating factor receptor treatment ISO RGD PMID:17515866 RGD:9999208 NCBI chrNW_004955452:7,309,854...7,345,579
Ensembl chrNW_004955452:7,311,901...7,312,929
JBrowse link
G Snai3 snail family transcriptional repressor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chrNW_004955541:2,593,530...2,599,105
Ensembl chrNW_004955541:2,593,351...2,599,175
JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163
JBrowse link
G Sord sorbitol dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chrNW_004955409:8,305,819...8,333,733
Ensembl chrNW_004955409:8,303,602...8,333,869
JBrowse link
G Tjp1 tight junction protein 1 ISO protein:increased expression:liver RGD PMID:19390485 RGD:2317627 NCBI chrNW_004955416:28,640,807...28,869,717
Ensembl chrNW_004955416:28,654,905...28,870,555
JBrowse link
G Tlr1 toll like receptor 1 ISO mRNA:increased expression:ileum RGD PMID:19608731 RGD:5128779 NCBI chrNW_004955443:8,442,419...8,450,318
Ensembl chrNW_004955443:8,447,956...8,450,382
JBrowse link
G Tlr2 toll like receptor 2 ISO mRNA:increased expression:ileum RGD PMID:19608731 RGD:5128779 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
JBrowse link
G Tlr3 toll like receptor 3 ISO mRNA:increased expression:ileum (rat) RGD PMID:19608731 RGD:5128779 NCBI chrNW_004955403:22,977,882...23,001,392
Ensembl chrNW_004955403:22,979,120...23,001,467
JBrowse link
G Tlr4 toll like receptor 4 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:ileum
mRNA:increased expression:ileum
CTD
RGD
PMID:19608731 PMID:21240009 PMID:23650378 RGD:5128779 RGD:5490305 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
JBrowse link
G Tlr5 toll like receptor 5 ISO mRNA:decreased expression:ileum (rat) RGD PMID:19608731 RGD:5128779 NCBI chrNW_004955520:1,544,840...1,562,081
Ensembl chrNW_004955520:1,556,523...1,559,093
JBrowse link
G Tlr6 toll like receptor 6 ISO mRNA:increased expression:ileum RGD PMID:19608731 RGD:5128779 NCBI chrNW_004955443:8,401,461...8,427,175
Ensembl chrNW_004955443:8,422,534...8,424,942
JBrowse link
G Tlr7 toll like receptor 7 ISO mRNA:increased expression:ileum RGD PMID:19608731 RGD:5128779 NCBI chrNW_004955544:424,897...443,562
Ensembl chrNW_004955544:424,850...443,564
JBrowse link
G Tlr9 toll like receptor 9 ISO mRNA:increased expression:ileum (rat) RGD PMID:19608731 RGD:5128779 NCBI chrNW_004955532:3,828,645...3,832,699
Ensembl chrNW_004955532:3,828,775...3,832,582
JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:intestine
protein:increased expression:serum
mRNA:increased expression:ileum (rat)
RGD PMID:16269520 PMID:19824106 PMID:20501441 RGD:1580205 RGD:2324672 RGD:4144091 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
JBrowse link
G Tubb tubulin beta class I ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chrNW_004955583:704,811...715,742
Ensembl chrNW_004955583:704,750...718,649
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14337
    disease of anatomical entity 14030
      gastrointestinal system disease 6100
        gastroenteritis 494
          Enterocolitis 60
            perinatal necrotizing enterocolitis 46
Path 2
Term Annotations click to browse term
  disease 14337
    disease of anatomical entity 14030
      Immune & Inflammatory Diseases 4818
        Inflammation 2305
          gastroenteritis 494
            Enterocolitis 60
              perinatal necrotizing enterocolitis 46
paths to the root