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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:perinatal necrotizing enterocolitis
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Accession:DOID:8677 term browser browse the term
Definition:ENTEROCOLITIS with extensive ulceration (ULCER) and NECROSIS. It is observed primarily in LOW BIRTH WEIGHT INFANT.
Synonyms:exact_synonym: NEC;   necrotizing enterocolitis;   necrotizing enterocolitis in fetus or newborn;   perinatal necrotising enterocolitis;   pseudomembranous enterocolitis in newborn
 primary_id: MESH:D020345
 xref: EFO:0003928;   ICD10CM:K55.3;   ICD10CM:K55.30
For additional species annotation, visit the Alliance of Genome Resources.


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perinatal necrotizing enterocolitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A susceptibility ISO RGD PMID:21788941 RGD:8657143 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Becn1 beclin 1 ISO protein:increased expression:intestine RGD PMID:20539009 RGD:6483081 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO protein:increased expression:ileum RGD PMID:16002567 RGD:11561971 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Cd14 CD14 molecule disease_progression ISO
IDA		 protein:increased expression:small intestine RGD PMID:19824106 PMID:19824106 RGD:4144091, RGD:4144091 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd40 CD40 molecule IEP protein:decreased expression:ileum RGD PMID:21240009 RGD:5490305 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd40lg CD40 ligand IEP protein:decreased expression:ileum RGD PMID:21240009 RGD:5490305 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cryl1 crystallin, lambda 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997 		JBrowse link
G Egf epidermal growth factor treatment IDA RGD PMID:19390485 PMID:18607263 RGD:2317627, RGD:10395236 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Eno1 enolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor treatment ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:16567187 PMID:18607263 RGD:10395236 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma treatment IDA RGD PMID:17426653 RGD:12791281 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Il10 interleukin 10 treatment IDA
ISO		 RGD PMID:23783008 PMID:22450025 RGD:7365018, RGD:11049491 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il10rb interleukin 10 receptor subunit beta IEP protein:increased expression:ileum RGD PMID:21240009 RGD:5490305 NCBI chr11:30,646,494...30,668,081
Ensembl chr11:30,652,096...30,668,074 		JBrowse link
G Il18 interleukin 18 ISO
IEP		 protein:increased expression:ileum
protein:increased expression:liver		 RGD PMID:17947451 PMID:21240009 PMID:12032269 PMID:12529262 RGD:4889475, RGD:5490305, RGD:729222, RGD:4889473 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta IDA RGD PMID:23158403 RGD:7175550 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 treatment IEP RGD PMID:20501441 RGD:2324672 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lgals2 galectin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr 7:110,403,171...110,410,046
Ensembl chr 7:110,403,173...110,404,802 		JBrowse link
G Ltf lactotransferrin ISO CTD Direct Evidence: therapeutic CTD PMID:16640825 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO protein:increased expression:intestine: RGD PMID:20716917 RGD:10412640 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming IEP mRNA:decreased expression:ileum RGD PMID:20501441 RGD:2324672 NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO RGD PMID:20580721 RGD:8547529 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17923197 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23650378 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Oat ornithine aminotransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Park7 Parkinsonism associated deglycase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 severity IEP
ISO		 protein:increased expression:intestinal mucosa RGD PMID:21399558 PMID:21399558 RGD:10413911, RGD:10413911 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO protein:increased expression:plasma RGD PMID:1304722 RGD:6483787 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Ptafr platelet-activating factor receptor treatment IDA RGD PMID:17515866 RGD:9999208 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
G Snai3 snail family transcriptional repressor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr19:50,516,771...50,529,295
Ensembl chr19:50,516,771...50,523,486 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sord sorbitol dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133 		JBrowse link
G Tjp1 tight junction protein 1 IEP protein:increased expression:liver RGD PMID:19390485 RGD:2317627 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tlr1 toll-like receptor 1 IEP mRNA:increased expression:ileum RGD PMID:19608731 RGD:5128779 NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125 		JBrowse link
G Tlr2 toll-like receptor 2 IEP mRNA:increased expression:ileum RGD PMID:19608731 RGD:5128779 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr3 toll-like receptor 3 IEP mRNA:increased expression:ileum (rat) RGD PMID:19608731 RGD:5128779 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tlr4 toll-like receptor 4 IEP
ISO		 mRNA:increased expression:ileum
CTD Direct Evidence: marker/mechanism
protein:increased expression:ileum		 CTD
RGD		 PMID:23650378 PMID:19608731 PMID:21240009 RGD:5128779, RGD:5490305 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr5 toll-like receptor 5 IEP mRNA:decreased expression:ileum (rat) RGD PMID:19608731 RGD:5128779 NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738 		JBrowse link
G Tlr6 toll-like receptor 6 IEP mRNA:increased expression:ileum RGD PMID:19608731 RGD:5128779 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685 		JBrowse link
G Tlr7 toll-like receptor 7 IEP mRNA:increased expression:ileum RGD PMID:19608731 RGD:5128779 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754 		JBrowse link
G Tlr9 toll-like receptor 9 IEP mRNA:increased expression:ileum (rat) RGD PMID:19608731 RGD:5128779 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnf tumor necrosis factor IEP
IDA		 protein:increased expression:serum
mRNA:increased expression:ileum (rat)		 RGD PMID:19824106 PMID:20501441 PMID:16269520 RGD:4144091, RGD:2324672, RGD:1580205 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tubb5 tubulin, beta 5 class I ISO CTD Direct Evidence: marker/mechanism CTD PMID:18806098 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19141
    disease of anatomical entity 18453
      gastrointestinal system disease 7189
        gastroenteritis 571
          Enterocolitis 64
            perinatal necrotizing enterocolitis 46
Path 2
Term Annotations click to browse term
  disease 19141
    disease of anatomical entity 18453
      Immune & Inflammatory Diseases 5752
        Inflammation 2843
          gastroenteritis 571
            Enterocolitis 64
              perinatal necrotizing enterocolitis 46
paths to the root