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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:substance-induced psychosis
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Accession:DOID:8646 term browser browse the term
Definition:Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.
Synonyms:exact_synonym: Drug Psychoses;   Toxic Psychoses;   substance-induced psychoses
 primary_id: MESH:D011605;   RDO:0006434
 xref: ICD9CM:293.89
For additional species annotation, visit the Alliance of Genome Resources.

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substance-induced psychosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20799992 NCBI chr19:7,691,678...7,706,781
Ensembl chr19:7,691,536...7,706,926 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21041608 NCBI chr24:82,704,087...82,730,711
Ensembl chr24:82,704,068...82,727,698 		JBrowse link
G CAMK2B calcium/calmodulin dependent protein kinase II beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:17603807 NCBI chr21:14,342,751...14,451,274
Ensembl chr21:14,342,892...14,451,282 		JBrowse link
G ESR1 estrogen receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19386276 NCBI chr13:79,153,418...79,554,552
Ensembl chr13:79,270,265...79,554,549 		JBrowse link
G GRM2 glutamate metabotropic receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20211215 NCBI chr22:13,044,974...13,056,469
Ensembl chr22:13,046,641...13,056,453 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15729709 NCBI chr 1:6,676,897...6,679,936 JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19747927 NCBI chr 4:60,159,542...60,162,947
Ensembl chr 4:60,159,944...60,161,212 		JBrowse link
G HTR6 5-hydroxytryptamine receptor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20705401 NCBI chr20:112,873,132...112,887,533
Ensembl chr20:112,874,734...112,887,066 		JBrowse link
G NPY1R neuropeptide Y receptor Y1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19566775 NCBI chr 7:109,774,700...109,794,543
Ensembl chr 7:109,774,918...109,776,905 		JBrowse link
G OPRM1 opioid receptor mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16402083 NCBI chr13:81,568,295...81,650,005
Ensembl chr13:81,568,732...81,625,088 		JBrowse link
G PHB1 prohibitin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18504422 NCBI chr16:69,805,968...69,816,792
Ensembl chr16:69,806,923...69,816,754 		JBrowse link
G PICK1 protein interacting with PRKCA 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17606663 NCBI chr19:20,758,199...20,778,210
Ensembl chr19:20,759,960...20,779,514 		JBrowse link
G RGS9 regulator of G protein signaling 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17318883 NCBI chr16:56,199,051...56,291,002
Ensembl chr16:56,199,343...56,288,290 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12931138 NCBI chr 4:1,209,013...1,258,797
Ensembl chr 4:1,209,019...1,258,866 		JBrowse link
G SNCA synuclein alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:15542733 NCBI chr 7:38,083,154...38,194,068
Ensembl chr 7:38,081,509...38,191,479 		JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16807759 NCBI chr13:87,284,537...87,297,998
Ensembl chr13:87,280,686...87,297,974 		JBrowse link
alcohol-induced mental disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member ISO CTD Direct Evidence: marker/mechanism CTD PMID:26711020 NCBI chr11:107,019,015...107,060,784
Ensembl chr11:107,019,111...107,060,374 		JBrowse link
G ANKK1 ankyrin repeat and kinase domain containing 1 ISO DNA:SNP:exon:rs1800497(human) RGD PMID:18669994 RGD:401959336 NCBI chr 1:104,752,023...104,765,071 JBrowse link
G DRD2 dopamine receptor D2 ISO DNA:SNP:cds:957C>T(human) RGD PMID:18669994 RGD:401959336 NCBI chr 1:104,774,632...104,843,417
Ensembl chr 1:104,774,180...104,842,736 		JBrowse link
G FOXO4 forkhead box O4 ISO protein:increased phosphorylation:small intestine: RGD PMID:23292333 RGD:10402360 NCBI chr  X:60,893,711...60,901,134
Ensembl chr  X:60,893,526...60,902,844 		JBrowse link
G GSR glutathione-disulfide reductase treatment ISO RGD PMID:24972622 RGD:10401897 NCBI chr 8:28,778,713...28,851,907 JBrowse link
G HECTD4 HECT domain E3 ubiquitin protein ligase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35713687 NCBI chr11:107,403,854...107,624,534
Ensembl chr11:107,405,887...107,596,312 		JBrowse link
alcohol-related birth defects term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK3 ankyrin 3 ISO DNA:SNP:CDS:rs7917190 RGD PMID:29109170 RGD:597830079 NCBI chr 9:70,549,665...71,253,928
Ensembl chr 9:70,893,260...71,254,245 		JBrowse link
G ARHGEF10 Rho guanine nucleotide exchange factor 10 ISO associated with cleft lip; DNA:SNP: :rs2294035, rs4876274 RGD PMID:31372216 RGD:597830081 NCBI chr 8:1,487,076...1,620,387
Ensembl chr 8:1,502,226...1,620,389 		JBrowse link
G RPS6KA1 ribosomal protein S6 kinase A1 ISO DNA:SNP:CDS:rs4659444 RGD PMID:29109170 RGD:597830079 NCBI chr20:106,180,708...106,226,636
Ensembl chr20:106,180,418...106,226,552 		JBrowse link
alcoholic psychosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR2A 5-hydroxytryptamine receptor 2A ISO DNA:SNP:promoter:-1438G>A RGD PMID:11842624 RGD:401900738 NCBI chr 3:24,820,029...24,884,472
Ensembl chr 3:24,820,035...24,883,432 		JBrowse link
drug psychosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB2 arrestin beta 2 ISO protein:increased expression:striatum RGD PMID:26174132 RGD:11534754 NCBI chr16:4,191,040...4,202,382
Ensembl chr16:4,191,172...4,202,385 		JBrowse link
G DRD2 dopamine receptor D2 ISO RGD PMID:26174132 RGD:11534754 NCBI chr 1:104,774,632...104,843,417
Ensembl chr 1:104,774,180...104,842,736 		JBrowse link
G GAD1 glutamate decarboxylase 1 susceptibility ISO associated with amphetamine abuse; DNA:haplotype: :rs769404���rs701492(human)
protein:decreased expression:prefrontal cortex 		RGD PMID:24200867 PMID:27967329 RGD:401900122 RGD:401900162 NCBI chr10:56,351,495...56,396,476
Ensembl chr10:56,353,253...56,396,524 		JBrowse link
G GAD2 glutamate decarboxylase 2 susceptibility ISO associated with amphetamine abuse; DNA:SNP: :rs2236418(human) RGD PMID:27967329 RGD:401900122 NCBI chr 9:25,906,047...25,993,715
Ensembl chr 9:25,906,103...25,995,489 		JBrowse link
G OPRM1 opioid receptor mu 1 ISO associated with amphetamine abuse;DNA:SNP:intron:IVS2+691G>C (human) RGD PMID:16402083 RGD:401827939 NCBI chr13:81,568,295...81,650,005
Ensembl chr13:81,568,732...81,625,088 		JBrowse link
fetal alcohol spectrum disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK3 ankyrin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29109170 NCBI chr 9:70,549,665...71,253,928
Ensembl chr 9:70,893,260...71,254,245 		JBrowse link
G APOE apolipoprotein E ISO RGD PMID:15007105 RGD:12904641 NCBI chr 6:38,377,154...38,381,219
Ensembl chr 6:38,376,887...38,381,438 		JBrowse link
G AVP arginine vasopressin ISO mRNA:decreased expression:hypothalamic nucleus RGD PMID:15142835 RGD:596933086 NCBI chr 2:33,761,066...33,764,608
Ensembl chr 2:33,761,140...33,763,172 		JBrowse link
G BPIFA1 BPI fold containing family A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15513904 NCBI chr 2:37,571,577...37,579,529
Ensembl chr 2:37,573,837...37,578,667 		JBrowse link
G C3 complement C3 ISO protein:increased activity:blood RGD PMID:30657461 RGD:408418720 NCBI chr 6:6,250,422...6,289,264 JBrowse link
G C5 complement C5 ISO protein:increased activity:blood RGD PMID:30657461 RGD:408418720 NCBI chr12:18,525,855...18,624,048
Ensembl chr12:18,525,880...18,623,636 		JBrowse link
G CAT catalase ISO CTD Direct Evidence: therapeutic CTD PMID:26074427 NCBI chr 1:30,792,533...30,828,920
Ensembl chr 1:30,792,399...30,829,592 		JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 sexual_dimorphism ISO associated with chronic mild stress, age effect; mRNA:altered expression:hippocampus (rat) RGD PMID:29251811 RGD:401965484 NCBI chr16:60,070,156...60,120,857
Ensembl chr16:60,070,066...60,120,712 		JBrowse link
G DIO3 iodothyronine deiodinase 3 treatment ISO RGD PMID:23763370 RGD:13432044 NCBI chr24:79,538,264...79,544,448 JBrowse link
G DNMT1 DNA methyltransferase 1 ISO mRNA,protein:increased expression:Pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr 6:9,199,006...9,263,890
Ensembl chr 6:9,199,003...9,263,607 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta ISO mRNA:increased expression:pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr 2:37,128,635...37,176,033
Ensembl chr 2:37,146,538...37,174,570 		JBrowse link
G DRD2 dopamine receptor D2 ISO DNA:Hypermethylation:promoter
mRNA:decreased expression: pituitary gland (rat) 		RGD PMID:26509893 PMID:28710248 RGD:11344152 RGD:401960105 NCBI chr 1:104,774,632...104,843,417
Ensembl chr 1:104,774,180...104,842,736 		JBrowse link
G EHMT2 euchromatic histone lysine methyltransferase 2 ISO mRNA:increased expression:pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr17:40,123,935...40,141,942
Ensembl chr17:40,124,640...40,141,616 		JBrowse link
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 treatment
sexual_dimorphism 		ISO in male mice only; mRNA:increased expression:frontal cortex: RGD PMID:23763370 PMID:30312858 RGD:13432044 RGD:405866345 NCBI chr26:55,319,667...55,543,116
Ensembl chr26:55,471,907...55,538,855 		JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 ISO mRNA:increased expression:posterior hypothalamic region (rat) RGD PMID:18514412 RGD:402528884 NCBI chr23:64,422,519...64,512,124
Ensembl chr23:64,422,391...64,513,652 		JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B treatment ISO RGD PMID:22037411 PMID:23763370 RGD:13210751 RGD:13432044 NCBI chr11:13,444,155...13,873,034
Ensembl chr11:13,456,968...13,873,202 		JBrowse link
G HDAC2 histone deacetylase 2 ISO mRNA,protein:increased expression:pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr13:59,873,248...59,904,542
Ensembl chr13:59,873,767...59,905,742 		JBrowse link
G HDAC4 histone deacetylase 4 ISO mRNA,protein:increased expression:pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr10:125,098,375...125,450,524
Ensembl chr10:125,098,366...125,403,227 		JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 ISO protein:increased expression:placenta (rat) RGD PMID:26342748 RGD:401965481 NCBI chr 5:60,017,967...60,040,959
Ensembl chr 5:60,019,434...60,025,353 		JBrowse link
G IGF1 insulin like growth factor 1 ISO mRNA:decreased expression:cerebellum (rat) RGD PMID:16909201 RGD:12904886 NCBI chr11:97,624,498...97,708,730
Ensembl chr11:97,631,189...97,707,308 		JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO protein:decreased activity:cerebellum (rat) RGD PMID:16909201 RGD:12904886 NCBI chr29:17,212,206...17,534,036
Ensembl chr29:17,459,404...17,526,930 		JBrowse link
G MAT2A methionine adenosyltransferase 2A ISO mRNA:decreased expression:brain (rat) RGD PMID:26180184 RGD:11074449 NCBI chr14:21,609,533...21,615,822
Ensembl chr14:21,611,040...21,615,615 		JBrowse link
G MECP2 methyl-CpG binding protein 2 treatment ISO mRNA:increased expression:pituitary gland (rat) RGD PMID:23763370 PMID:26509893 RGD:11344152 RGD:13432044 NCBI chr  X:128,445,028...128,519,892
Ensembl chr  X:128,453,577...128,455,785 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO mRNA:decreased expression:brain (rat) RGD PMID:26180184 RGD:11074449 NCBI chr25:73,935,666...74,039,872
Ensembl chr25:73,935,225...74,038,741 		JBrowse link
G NOS1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25511929 NCBI chr11:112,642,374...112,673,882 JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 sexual_dimorphism ISO associated with chronic mild stress, age effect; mRNA:altered expression:hippocampus (rat) RGD PMID:29251811 RGD:401965484 NCBI chr 7:94,574,010...94,935,348 JBrowse link
G OPRK1 opioid receptor kappa 1 ISO DNA, mRNA:hypomethylation, increased expression:ventral tegmental area, prefrontal cortex RGD PMID:29678771 RGD:401851055 NCBI chr 8:49,337,308...49,364,724
Ensembl chr 8:49,341,427...49,362,947 		JBrowse link
G OPRL1 opioid related nociceptin receptor 1 ISO mRNA:decreased expression:ventral tegmental area RGD PMID:29678771 RGD:401851055 NCBI chr 2:155,881...166,480
Ensembl chr 2:148,339...155,292
Ensembl chr 2:148,339...155,292 		JBrowse link
G PDYN prodynorphin ISO DNA, mRNA:hypomethylation, altered expression:ventral tegmental area, nucleus accumbens RGD PMID:29678771 RGD:401851055 NCBI chr 2:54,535,516...54,551,085
Ensembl chr 2:54,535,240...54,551,104 		JBrowse link
G PER2 period circadian regulator 2 treatment ISO RGD PMID:31329297 RGD:405878078 NCBI chr10:124,270,917...124,316,031
Ensembl chr10:124,269,543...124,315,904 		JBrowse link
G PNOC prepronociceptin ISO mRNA:increased expression:nucleus accumbens RGD PMID:29678771 RGD:401851055 NCBI chr 8:26,418,473...26,444,689
Ensembl chr 8:26,418,815...26,444,677 		JBrowse link
G POMC proopiomelanocortin treatment ISO RGD PMID:31329297 RGD:405878078 NCBI chr14:82,491,296...82,499,289
Ensembl chr14:82,494,323...82,499,447 		JBrowse link
G PRL prolactin ISO mRNA,protein:increased expression:pituitary gland, blood plasma (rat)
mRNA, protein:increased expression:pituitary gland, blood plasma (rat) 		RGD PMID:26509893 PMID:28710248 RGD:11344152 RGD:401960105 NCBI chr17:49,922,750...49,938,084
Ensembl chr17:49,928,321...49,938,631 		JBrowse link
G PTEN phosphatase and tensin homolog ISO Protein:increased expression, increased activity:cerebellum (rat) RGD PMID:12700235 RGD:12801493 NCBI chr 9:81,308,058...81,412,386
Ensembl chr 9:81,309,099...81,409,146 		JBrowse link
G RASGRF1 Ras protein specific guanine nucleotide releasing factor 1 treatment ISO RGD PMID:23763370 RGD:13432044 NCBI chr26:4,298,091...4,431,606
Ensembl chr26:4,299,116...4,432,420 		JBrowse link
G RPS6KA1 ribosomal protein S6 kinase A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29109170 NCBI chr20:106,180,708...106,226,636
Ensembl chr20:106,180,418...106,226,552 		JBrowse link
G SETD7 SET domain containing 7, histone lysine methyltransferase ISO mRNA:decreased expression:pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr 7:86,476,101...86,528,146
Ensembl chr 7:86,481,726...86,527,779 		JBrowse link
G SLC25A12 solute carrier family 25 member 12 treatment ISO RGD PMID:23763370 RGD:13432044 NCBI chr10:57,268,948...57,387,958
Ensembl chr10:57,265,550...57,387,910 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 ISO mRNA:decreased expression:brain (rat) RGD PMID:26180184 RGD:11074449 NCBI chr16:23,929,196...23,969,665
Ensembl chr16:23,927,311...23,955,616 		JBrowse link
G TLR4 toll like receptor 4 ameliorates ISO RGD PMID:30312858 RGD:405866345 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G UBE3A ubiquitin protein ligase E3A treatment ISO RGD PMID:23763370 RGD:13432044 NCBI chr26:56,638,936...56,738,555
Ensembl chr26:56,666,162...56,736,737 		JBrowse link
fetal alcohol syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RHOA ras homolog family member A ISO protein:increased activation:neuron, cerebellum RGD PMID:17109064 RGD:2298867 NCBI chr22:10,757,381...10,809,257
Ensembl chr22:10,757,337...10,772,704 		JBrowse link
Postoperative Cognitive Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor ISO mRNA, protein:increased expression:hippocampus RGD PMID:23078219 RGD:597805826 NCBI chr17:39,847,343...39,851,288
Ensembl chr17:39,847,759...39,851,127 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:24814703 RGD:10047100 NCBI chr15:41,957,826...42,002,776 JBrowse link
G AKT1 AKT serine/threonine kinase 1 treatment ISO RGD PMID:30221701 RGD:597931096 NCBI chr24:82,704,087...82,730,711
Ensembl chr24:82,704,068...82,727,698 		JBrowse link
G APP amyloid beta precursor protein treatment ISO protein:increased expression:hippocampus
protein:increased expression:plasma 		RGD PMID:30221701 PMID:33574912 PMID:35317728 RGD:597830151 RGD:597830178 RGD:597931096 NCBI chr 2:66,037,224...66,320,860
Ensembl chr 2:66,037,261...66,321,306 		JBrowse link
G BACE1 beta-secretase 1 treatment ISO RGD PMID:30221701 PMID:33574912 RGD:597830178 RGD:597931096 NCBI chr 1:108,659,723...108,689,879
Ensembl chr 1:108,657,584...108,689,843 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:33574912 RGD:597830178 NCBI chr 6:42,186,028...42,193,105 JBrowse link
G BCL2 BCL2 apoptosis regulator treatment ISO RGD PMID:33574912 RGD:597830178 NCBI chr18:16,440,560...16,643,187
Ensembl chr18:16,441,733...16,637,895 		JBrowse link
G BDNF brain derived neurotrophic factor treatment ISO associated with brain ischemia RGD PMID:29065194 PMID:29571823 PMID:29599834 PMID:30232930 PMID:32564283 More... RGD:401959211 RGD:401965400 RGD:401976548 RGD:405850212 RGD:596933096 RGD:596936243 RGD:596936414 NCBI chr 1:37,386,825...37,451,380
Ensembl chr 1:37,449,593...37,450,336 		JBrowse link
G CASP3 caspase 3 treatment ISO RGD PMID:30221701 PMID:33574912 RGD:597830178 RGD:597931096 NCBI chr 7:130,589,592...130,610,845
Ensembl chr 7:130,591,166...130,610,899 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 treatment ISO protein:decreased phosphorylation:hippocampus RGD PMID:29571823 PMID:36688960 PMID:37736695 RGD:401959211 RGD:401959611 RGD:401960090 NCBI chr10:93,316,774...93,395,187
Ensembl chr10:93,316,840...93,388,832 		JBrowse link
G GDNF glial cell derived neurotrophic factor treatment ISO protein:decreased expression:hippocampus,urine
associated with rheumatic heart disease;protein:increased expression:serum
protein:altered expression:hippocampus, urine 		RGD PMID:25251457 PMID:28918204 PMID:29512789 PMID:33324197 PMID:34728231 More... RGD:401959611 RGD:405849389 RGD:405850212 RGD:405850250 RGD:405850251 RGD:405866364 NCBI chr 4:36,662,033...36,691,761
Ensembl chr 4:36,665,009...36,684,257 		JBrowse link
G HMGB1 high mobility group box 1 ISO mRNA, protein:increased expression:hippocampus RGD PMID:23078219 RGD:597805826 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G IGF1 insulin like growth factor 1 treatment ISO mRNA:decreased expression:hippocampus
mRNA:decreased expression:plasma 		RGD PMID:33574912 PMID:35317728 RGD:597830151 RGD:597830178 NCBI chr11:97,624,498...97,708,730
Ensembl chr11:97,631,189...97,707,308 		JBrowse link
G IGFBP7 insulin like growth factor binding protein 7 ISO protein:increased expression:plasma (human) RGD PMID:25543030 RGD:401960875 NCBI chr 7:11,617,096...11,694,530 JBrowse link
G IL1B interleukin 1 beta treatment ISO protein:increased expression:hippocampus (rat)
mRNA, protein:increased expression:hippocampus 		RGD PMID:22959208 PMID:23078219 PMID:29571823 PMID:30221701 PMID:33390808 RGD:401959211 RGD:401965467 RGD:597805826 RGD:597931096 RGD:7204702 NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729 		JBrowse link
G IL1RN interleukin 1 receptor antagonist treatment ISO human protein in a rat model RGD PMID:23077050 RGD:8551854 NCBI chr14:16,136,667...16,152,451
Ensembl chr14:16,146,333...16,151,326 		JBrowse link
G IL6 interleukin 6 treatment ISO protein:increased expression:hippocampus (rat) RGD PMID:28684969 PMID:30221701 PMID:33390808 RGD:401965467 RGD:597538492 RGD:597931096 NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237 		JBrowse link
G IREB2 iron responsive element binding protein 2 ISO protein:increased expression:hippocampus (rat) RGD PMID:23229539 RGD:12904023 NCBI chr26:4,842,328...4,905,941
Ensembl chr26:4,842,122...4,905,964 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 treatment ISO protein:decreased phosphorylation:hippocampus RGD PMID:36688960 PMID:37736695 RGD:401959611 RGD:401960090 NCBI chr19:4,246,144...4,352,648
Ensembl chr19:4,246,122...4,353,325 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 treatment ISO protein:decreased phosphorylation:hippocampus RGD PMID:36688960 PMID:37736695 RGD:401959611 RGD:401960090 NCBI chr 5:26,536,471...26,545,666
Ensembl chr 5:26,536,532...26,546,461 		JBrowse link
G NGF nerve growth factor treatment ISO associated with brain ischemia RGD PMID:29599834 PMID:30481505 PMID:34964700 RGD:401965395 RGD:401965400 RGD:401976548 NCBI chr20:18,361,795...18,413,987
Ensembl chr20:18,413,108...18,413,833 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 treatment ISO associated with Traumatic Brain Injuries;mRNA:decreased expression:hippocampus, hypothalamus RGD PMID:28086911 PMID:36637480 RGD:408345237 RGD:408364984 NCBI chr23:45,904,926...46,031,804
Ensembl chr23:45,904,873...46,031,125 		JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 ISO protein:increased expression:hippocampus (rat) RGD PMID:33390808 RGD:401965467 NCBI chr 7:94,574,010...94,935,348 JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 treatment ISO RGD PMID:29065194 PMID:30232930 PMID:32564283 RGD:596933096 RGD:596936243 RGD:596936414 NCBI chr12:95,477,612...95,836,734
Ensembl chr12:95,479,447...95,620,364 		JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta treatment ISO RGD PMID:30221701 RGD:597931096 NCBI chr15:51,705,585...51,885,848
Ensembl chr15:51,775,733...51,889,238 		JBrowse link
G TLR2 toll like receptor 2 treatment ISO RGD PMID:28684969 PMID:32300366 RGD:597538486 RGD:597538492 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
G TLR4 toll like receptor 4 treatment ISO RGD PMID:28684969 PMID:32300366 RGD:597538486 RGD:597538492 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G TNF tumor necrosis factor treatment ISO protein:increased expression:hippocampus (rat)
mRNA, protein:increased expression:hippocampus 		RGD PMID:23078219 PMID:29571823 PMID:33390808 RGD:401959211 RGD:401965467 RGD:597805826
subacute delirium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) disease_progression ISO RGD PMID:8043620 RGD:405855847 NCBI chr28:12,328,304...12,335,302
Ensembl chr28:12,331,039...12,335,076 		JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A ISO mRNA, protein:increased expression:hippocampal formation, amygdala RGD PMID:27760517 RGD:405850209 NCBI chr 4:60,159,542...60,162,947
Ensembl chr 4:60,159,944...60,161,212 		JBrowse link
G TPH2 tryptophan hydroxylase 2 ISO mRNA:increased expression:hippocampus, prefrontal cortex RGD PMID:36750928 RGD:597805905 NCBI chr11:67,568,744...67,664,911 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15628
    Chemically-Induced Disorders 1260
      substance-related disorder 689
        substance-induced psychosis 94
          alcohol-induced mental disorder + 49
          drug-induced mental disorder + 5
          subacute delirium + 31
Path 2
Term Annotations click to browse term
  disease 15628
    disease of anatomical entity 15289
      nervous system disease 13411
        central nervous system disease 11991
          brain disease 11258
            disease of mental health 8120
              cognitive disorder 2127
                psychotic disorder 1153
                  substance-induced psychosis 94
                    alcohol-induced mental disorder + 49
                    drug-induced mental disorder + 5
                    subacute delirium + 31
paths to the root