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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:herpes simplex
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Accession:DOID:8566 term browser browse the term
Definition:A viral infectious disease that results_in_formation_of lesions, located_in mouth, located_in face, located_in genitalia, or located_in hands, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person. (DO)
Synonyms:exact_synonym: Herpesvirus hominis disease
 related_synonym: Herpes simplex virus 2 seropositivity
 primary_id: MESH:D006561
 xref: EFO:0009339;   EFO:1002022;   ICD10CM:B00.9;   ICD9CM:054;   NCI:C155871
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
herpes simplex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO RGD PMID:17101197 RGD:7771596 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G C3 complement component 3 IMP RGD PMID:11509581 RGD:7401276 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP mRNA:increased expression:cornea (mouse) RGD PMID:9544579 RGD:8549472 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Cd1d1 CD1d1 antigen exacerbates IMP RGD PMID:18614643 RGD:127345112 NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748 		JBrowse link
G Cd274 CD274 antigen IMP RGD PMID:29669784 RGD:41412169 NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495 		JBrowse link
G Cd40lg CD40 ligand IMP RGD PMID:11134274 RGD:8547770 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Cd8a CD8 subunit alpha IEP mRNA:increased expression:trigeminal ganglion (mouse) RGD PMID:19151393 RGD:124715454 NCBI chr 6:71,350,411...71,356,155
Ensembl chr 6:71,350,411...71,356,157 		JBrowse link
G Dock8 dedicator of cytokinesis 8 severity IMP RGD PMID:25776845 RGD:11055046 NCBI chr19:24,976,753...25,179,796
Ensembl chr19:24,976,898...25,179,796 		JBrowse link
G Igf2bp1 insulin-like growth factor 2 mRNA binding protein 1 IMP RGD PMID:30050136 RGD:40902865 NCBI chr11:95,847,989...95,896,770
Ensembl chr11:95,847,989...95,896,766 		JBrowse link
G Il18 interleukin 18 treatment IDA RGD PMID:9971824 RGD:8655923 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il21 interleukin 21 treatment IMP
IEP		 mRNA:increased expression:spleen (mouse) RGD PMID:19233474 PMID:16406655 RGD:127285367, RGD:127285372 NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785 		JBrowse link
G Il33 interleukin 33 ISO
IEP		 protein:increased expression:skin RGD PMID:26872602 PMID:26872602 RGD:39939003, RGD:39939003 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118 		JBrowse link
G Irf5 interferon regulatory factor 5 susceptibility ISO associated with multiple sclerosis;DNA:SNP: :rs3807306 (human) RGD PMID:20861862 RGD:40924643 NCBI chr 6:29,526,129...29,541,874
Ensembl chr 6:29,526,624...29,541,870 		JBrowse link
G Mbl1 mannose-binding lectin (protein A) 1 IEP protein:increased expression:serum: RGD PMID:15498041 RGD:8693727 NCBI chr14:40,873,413...40,885,861
Ensembl chr14:40,873,415...40,881,558 		JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 susceptibility
disease_progression		 ISO DNA:polymorphism:cds: RGD PMID:19480845 PMID:15498041 PMID:15498041 RGD:8693725, RGD:8693727, RGD:8693727 NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087 		JBrowse link
G Nectin1 nectin cell adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10729168 NCBI chr 9:43,655,251...43,718,758
Ensembl chr 9:43,655,281...43,743,955 		JBrowse link
G Nectin2 nectin cell adhesion molecule 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10729168 PMID:11602758 PMID:30319691 NCBI chr 7:19,450,569...19,483,498
Ensembl chr 7:19,450,569...19,484,408 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 exacerbates IMP RGD PMID:30050136 PMID:25316792 RGD:40902865, RGD:127229943 NCBI chr14:56,022,452...56,026,314
Ensembl chr14:56,022,452...56,026,322 		JBrowse link
G Rpl30 ribosomal protein L30 ISO protein:increased serine phosphorylation:ribosome RGD PMID:7588575 RGD:11039399 NCBI chr15:34,440,649...34,443,405
Ensembl chr15:34,440,651...34,443,786 		JBrowse link
eczema herpeticum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ido1 indoleamine 2,3-dioxygenase 1 severity ISO associated with atopic dermatitis; protein:increased activity:serum (human) RGD PMID:26198597 RGD:11528429 NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025 		JBrowse link
G Ifng interferon gamma susceptibility ISO mRNA,protein:decreased expression:peripheral mononuclear cell:
DNA:haplotype::		 RGD PMID:21458658 PMID:21458658 RGD:6480259, RGD:6480259 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
genital herpes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 IDA RGD PMID:12502811 RGD:4890015 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ifnar1 interferon (alpha and beta) receptor 1 exacerbates IMP RGD PMID:28264883 RGD:125093738 NCBI chr16:91,281,016...91,307,411
Ensembl chr16:91,282,126...91,304,329 		JBrowse link
G Ifng interferon gamma IEP
IMP		 protein:increased expression:vaginal secretion: RGD PMID:10366565 PMID:10366565 RGD:8158034, RGD:8158034 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il21 interleukin 21 treatment IDA RGD PMID:24358128 RGD:127285365 NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785 		JBrowse link
G Il3 interleukin 3 ISO RNA: increased expression RGD PMID:21175248 RGD:5686876 NCBI chr11:54,155,911...54,158,105
Ensembl chr11:54,156,129...54,158,103 		JBrowse link
G Irf9 interferon regulatory factor 9 exacerbates IMP RGD PMID:28264883 RGD:125093738 NCBI chr14:55,841,442...55,847,487
Ensembl chr14:55,841,028...55,847,487 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 ameliorates IMP RGD PMID:31555293 RGD:42722615 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Rnasel ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) severity IMP RGD PMID:17157346 RGD:40902623 NCBI chr 1:153,625,089...153,644,441
Ensembl chr 1:153,625,172...153,639,967 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 treatment
severity		 ISO DNA:SNP:intron:rs7572482 (human)
DNA:SNPs, haplotype: :multiple		 RGD PMID:22718836 PMID:22718836 RGD:8661697, RGD:8661697 NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348 		JBrowse link
Herpes Simplex Encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E susceptibility ISO DNA:polymorphism:exon: RGD PMID:11118260 RGD:7771554 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Aqp4 aquaporin 4 IEP RGD PMID:17454447 RGD:8698664 NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039 		JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha treatment ISO RGD PMID:22761571 RGD:7240516 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592 		JBrowse link
G Calcr calcitonin receptor treatment ISO RGD PMID:22761571 RGD:7240516 NCBI chr 6:3,685,678...3,764,713
Ensembl chr 6:3,685,680...3,764,714 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IMP RGD PMID:22377584 RGD:8661752 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 IMP RGD PMID:23391218 RGD:8551839 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IMP RGD PMID:22377584 RGD:8661752 NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor IEP mRNA:increased expression:brain: RGD PMID:15950786 RGD:8657070 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 severity IMP RGD PMID:26872602 RGD:39939003 NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575 		JBrowse link
G Irf3 interferon regulatory factor 3 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272 		JBrowse link
G Lta lymphotoxin A IMP RGD PMID:11145686 RGD:8548806 NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327 		JBrowse link
G Mmp2 matrix metallopeptidase 2 IDA protein:increased activity:brain RGD PMID:15364410 RGD:8547868 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment IMP
IDA		 protein:increased activity:brain RGD PMID:20483026 PMID:15364410 RGD:8547867, RGD:8547868 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 susceptibility IMP RGD PMID:17266445 RGD:8661706 NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786 		JBrowse link
G Tlr2 toll-like receptor 2 disease_progression IMP
ISO		 RGD PMID:14739339 PMID:20806060 RGD:8553026, RGD:5130178 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr3 toll-like receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117 		JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:20806060 RGD:5130178 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tlr9 toll-like receptor 9 resistance ISO mRNA:increased expression:cheek (rat) RGD PMID:20806060 RGD:5130178 NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082 		JBrowse link
G Traf3 TNF receptor-associated factor 3 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr12:111,132,799...111,233,589
Ensembl chr12:111,132,804...111,233,587 		JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr19:3,985,222...3,999,340
Ensembl chr19:3,985,186...3,999,340 		JBrowse link
Herpes Simplex Encephalitis 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd37 ankyrin repeat domain 37 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr 8:46,449,945...46,452,904
Ensembl chr 8:46,449,939...46,458,744 		JBrowse link
G Ccdc110 coiled-coil domain containing 110 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr 8:46,387,656...46,398,643
Ensembl chr 8:46,387,656...46,397,182 		JBrowse link
G Cfap96 cilia and flagella associated protein 96 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr 8:46,387,980...46,428,290
Ensembl chr 8:46,406,643...46,428,477 		JBrowse link
G Cfap97 cilia and flagella associated protein 97 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr 8:46,615,515...46,648,627
Ensembl chr 8:46,604,808...46,648,627 		JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr 8:45,758,838...45,786,200
Ensembl chr 8:45,757,981...45,786,253 		JBrowse link
G F11 coagulation factor XI ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr 8:45,693,696...45,715,092
Ensembl chr 8:45,694,211...45,715,068 		JBrowse link
G Fam149a family with sequence similarity 149, member A ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr 8:45,789,752...45,835,328
Ensembl chr 8:45,789,754...45,835,328 		JBrowse link
G Fat1 FAT atypical cadherin 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr 8:45,386,137...45,505,294
Ensembl chr 8:45,388,484...45,505,294 		JBrowse link
G Klkb1 kallikrein B, plasma 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr 8:45,719,725...45,747,872
Ensembl chr 8:45,719,726...45,747,896 		JBrowse link
G Lrp2bp Lrp2 binding protein ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr 8:46,463,639...46,482,515
Ensembl chr 8:46,452,340...46,482,514 		JBrowse link
G Mtnr1a melatonin receptor 1A ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr 8:45,522,144...45,542,270
Ensembl chr 8:45,522,174...45,541,543 		JBrowse link
G Pdlim3 PDZ and LIM domain 3 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr 8:46,338,524...46,372,672
Ensembl chr 8:46,338,498...46,372,585 		JBrowse link
G Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr 8:46,660,205...46,664,099
Ensembl chr 8:46,659,834...46,664,321 		JBrowse link
G Snx25 sorting nexin 25 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr 8:46,486,298...46,605,535
Ensembl chr 8:46,486,298...46,605,196 		JBrowse link
G Sorbs2 sorbin and SH3 domain containing 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr 8:45,960,470...46,280,943
Ensembl chr 8:45,960,825...46,280,943 		JBrowse link
G Tbk1 TANK-binding kinase 1 ISO ClinVar Annotator: match by term: HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 1 ClinVar PMID:25700176 PMID:25803835 PMID:26476236 PMID:26581300 PMID:28492532 NCBI chr10:121,382,360...121,422,699
Ensembl chr10:121,382,360...121,422,692 		JBrowse link
G Tlr3 toll-like receptor 3 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis 1 | ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:9536098 PMID:15042513 PMID:16199547 PMID:17434873 PMID:17576681 More... NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117 		JBrowse link
G Ufsp2 UFM1-specific peptidase 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr 8:46,428,551...46,449,995
Ensembl chr 8:46,428,565...46,449,995 		JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator susceptibility ISO ClinVar Annotator: match by term: Herpes simplex encephalitis 1 | ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 OMIM
ClinVar		 PMID:9536098 PMID:16199547 PMID:16973841 PMID:17576681 PMID:24033266 More... NCBI chr19:3,985,222...3,999,340
Ensembl chr19:3,985,186...3,999,340 		JBrowse link
Herpes Simplex Encephalitis 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A530016L24Rik RIKEN cDNA A530016L24 gene ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,455,829...112,466,362
Ensembl chr12:112,455,882...112,466,361 		JBrowse link
G Adss1 adenylosuccinate synthase 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,586,481...112,607,789
Ensembl chr12:112,586,479...112,607,794 		JBrowse link
G Ahnak2 AHNAK nucleoprotein 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,738,631...112,766,278
Ensembl chr12:112,738,628...112,766,277 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Amn amnionless ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,237,530...111,242,860
Ensembl chr12:111,237,529...111,242,860 		JBrowse link
G Ankrd9 ankyrin repeat domain 9 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:110,942,854...110,945,516
Ensembl chr12:110,941,787...110,945,474 		JBrowse link
G Aspg asparaginase ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,073,117...112,094,007
Ensembl chr12:112,073,113...112,093,993 		JBrowse link
G Atp5mj ATP synthase membrane subunit j ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,927,808...111,933,443
Ensembl chr12:111,927,809...111,933,411 		JBrowse link
G Bag5 BCL2-associated athanogene 5 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,675,922...111,679,690
Ensembl chr12:111,675,922...111,679,691 		JBrowse link
G Brf1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,919,251...112,964,327
Ensembl chr12:112,923,705...112,964,324 		JBrowse link
G Btbd6 BTB domain containing 6 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,937,880...112,943,113
Ensembl chr12:112,940,102...112,942,565 		JBrowse link
G Cdc42bpb CDC42 binding protein kinase beta ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,259,406...111,347,985
Ensembl chr12:111,259,410...111,344,152 		JBrowse link
G Cdca4 cell division cycle associated 4 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,783,849...112,793,141
Ensembl chr12:112,783,849...112,793,043 		JBrowse link
G Cep170b centrosomal protein 170B ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,687,950...112,713,026
Ensembl chr12:112,686,889...112,713,026 		JBrowse link
G Cinp cyclin dependent kinase 2 interacting protein ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:110,839,044...110,855,579
Ensembl chr12:110,839,044...110,855,579 		JBrowse link
G Ckb creatine kinase, brain ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772 		JBrowse link
G Clba1 clathrin binding box of aftiphilin containing 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,772,595...112,779,865
Ensembl chr12:112,772,557...112,779,872 		JBrowse link
G Coa8 cytochrome c oxidase assembly factor 8 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,679,394...111,721,491
Ensembl chr12:111,679,695...111,721,487 		JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:110,567,829...110,633,378
Ensembl chr12:110,567,886...110,633,379 		JBrowse link
G Eif5 eukaryotic translation initiation factor 5 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,504,535...111,513,187
Ensembl chr12:111,504,450...111,513,186 		JBrowse link
G Exoc3l4 exocyst complex component 3-like 4 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,383,864...111,398,114
Ensembl chr12:111,383,451...111,398,112 		JBrowse link
G Gpr132 G protein-coupled receptor 132 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,814,493...112,832,035
Ensembl chr12:112,814,493...112,831,848 		JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162 		JBrowse link
G Inf2 inverted formin, FH2 and WH2 domain containing ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,555,121...112,581,991
Ensembl chr12:112,555,218...112,581,991 		JBrowse link
G Jag2 jagged 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,871,439...112,893,437
Ensembl chr12:112,871,439...112,893,396 		JBrowse link
G Kif26a kinesin family member 26A ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,109,378...112,148,181
Ensembl chr12:112,112,642...112,148,181 		JBrowse link
G Klc1 kinesin light chain 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,724,869...111,774,278
Ensembl chr12:111,725,283...111,774,278 		JBrowse link
G Mark3 MAP/microtubule affinity regulating kinase 3 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,540,929...111,622,661
Ensembl chr12:111,540,957...111,622,655 		JBrowse link
G Mok MOK protein kinase ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:110,770,404...110,807,391
Ensembl chr12:110,774,232...110,807,373 		JBrowse link
G Nudt14 nudix hydrolase 14 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,897,911...112,905,762
Ensembl chr12:112,897,911...112,905,744 		JBrowse link
G Pacs2 phosphofurin acidic cluster sorting protein 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,977,998...113,038,021
Ensembl chr12:112,978,128...113,038,021 		JBrowse link
G Pld4 phospholipase D family member 4 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,727,089...112,735,420
Ensembl chr12:112,727,089...112,735,424 		JBrowse link
G Ppp1r13b protein phosphatase 1, regulatory subunit 13B ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,794,892...111,874,549
Ensembl chr12:111,794,891...111,874,544 		JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:110,413,532...110,549,509
Ensembl chr12:110,413,554...110,549,496 		JBrowse link
G Rcor1 REST corepressor 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,005,801...111,082,336
Ensembl chr12:111,005,785...111,082,335 		JBrowse link
G Rd3l retinal degeneration 3-like ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,945,625...111,947,751
Ensembl chr12:111,945,545...111,947,751 		JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,611,262...112,615,586
Ensembl chr12:112,611,113...112,615,583 		JBrowse link
G Tdrd9 tudor domain containing 9 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,937,922...112,035,288
Ensembl chr12:111,937,993...112,035,288 		JBrowse link
G Tecpr2 tectonin beta-propeller repeat containing 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:110,855,681...110,938,828
Ensembl chr12:110,855,698...110,938,828 		JBrowse link
G Tmem179 transmembrane protein 179 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,466,618...112,477,594
Ensembl chr12:112,466,623...112,483,181 		JBrowse link
G Tnfaip2 tumor necrosis factor, alpha-induced protein 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,408,898...111,421,452
Ensembl chr12:111,408,903...111,421,452 		JBrowse link
G Traf3 TNF receptor-associated factor 3 susceptibility ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 | ClinVar Annotator: match by term: TRAF3 haploinsufficiency | ClinVar Annotator: match by term: TRAF3 related condition OMIM
ClinVar		 PMID:9536098 PMID:17576681 PMID:25741868 PMID:28492532 PMID:31681265 More... NCBI chr12:111,132,799...111,233,589
Ensembl chr12:111,132,804...111,233,587 		JBrowse link
G Trmt61a tRNA methyltransferase 61A ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,644,539...111,650,336
Ensembl chr12:111,644,539...111,650,336 		JBrowse link
G Wdr20 WD repeat domain 20 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:110,701,459...110,770,709
Ensembl chr12:110,704,378...110,770,672 		JBrowse link
G Xrcc3 X-ray repair complementing defective repair in Chinese hamster cells 3 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,769,626...111,780,326
Ensembl chr12:111,769,626...111,780,307 		JBrowse link
G Zbtb42 zinc finger and BTB domain containing 42 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:112,645,042...112,649,181
Ensembl chr12:112,645,262...112,649,181 		JBrowse link
G Zfp839 zinc finger protein 839 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:110,816,686...110,838,346
Ensembl chr12:110,816,687...110,836,430 		JBrowse link
G Zfyve21 zinc finger, FYVE domain containing 21 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr12:111,780,600...111,794,822
Ensembl chr12:111,780,604...111,798,626 		JBrowse link
Herpes Simplex Encephalitis 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ticam1 TIR domain containing adaptor molecule 1 susceptibility ISO ClinVar Annotator: match by term: ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 6 | ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 4 OMIM
ClinVar		 PMID:22105173 PMID:24033266 PMID:25741868 PMID:26513235 PMID:28492532 NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786 		JBrowse link
Herpes Simplex Encephalitis 7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf3 interferon regulatory factor 3 susceptibility ISO ClinVar Annotator: match by term: Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7 OMIM
ClinVar		 PMID:25741868 PMID:26216125 PMID:26513235 PMID:28492532 NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272 		JBrowse link
herpes simplex virus keratitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E treatment ISO RGD PMID:18515564 RGD:7771550 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Atm ataxia telangiectasia mutated ameliorates IMP RGD PMID:24370835 RGD:126781690 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 severity IMP associated with Herpes Simplex, Type 1 RGD PMID:16997857 RGD:8548890 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 IEP RGD PMID:15287366 RGD:7483593 NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 IMP RGD PMID:18798077 PMID:16476970 RGD:8551819, RGD:8551837 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 IEP RGD PMID:15287366 RGD:7483593 NCBI chr17:8,454,875...8,477,353
Ensembl chr17:8,454,875...8,475,973 		JBrowse link
G Cd274 CD274 antigen IMP RGD PMID:16253242 RGD:41410794 NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 IMP RGD PMID:18798077 RGD:8551819 NCBI chr  X:100,775,141...100,777,753
Ensembl chr  X:100,775,141...100,777,875 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 treatment IMP RGD PMID:15670795 RGD:40902819 NCBI chr17:79,157,933...79,190,001
Ensembl chr17:79,159,993...79,190,002 		JBrowse link
G Ifnb1 interferon beta 1, fibroblast treatment IMP RGD PMID:15670795 RGD:40902819 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011 		JBrowse link
G Ifng interferon gamma IMP RGD PMID:12162877 RGD:8157603 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il10 interleukin 10 treatment IDA RGD PMID:22467659 RGD:7364834 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1b interleukin 1 beta IEP mRNA:increased expression:cornea RGD PMID:10624423 RGD:7401196 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO human protein in a mouse model RGD PMID:15258192 RGD:8549793 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Il21 interleukin 21 treatment IMP RGD PMID:29370719 PMID:21204603 RGD:127285376, RGD:127285545 NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785 		JBrowse link
G Il23a interleukin 23, alpha subunit p19 IEP mRNA;increased expression:trigeminal ganglion (mouse) RGD PMID:12162874 RGD:39457946 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621 		JBrowse link
G Kdr kinase insert domain protein receptor treatment IEP
IDA		 protein:increased expression:cornea: RGD PMID:16951377 PMID:16951377 RGD:8549742, RGD:8549742 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Rnasel ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) treatment IMP RGD PMID:15670795 RGD:40902819 NCBI chr 1:153,625,089...153,644,441
Ensembl chr 1:153,625,172...153,639,967 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 susceptibility IMP RGD PMID:17266445 RGD:8661706 NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348 		JBrowse link
G Tlr2 toll-like receptor 2 IMP RGD PMID:17686871 RGD:7794851 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr4 toll-like receptor 4 IMP
ISO		 mRNA:increased expression:cornea: RGD PMID:17686871 PMID:17667620 RGD:7794851, RGD:8552970 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tlr9 toll-like receptor 9 IMP RGD PMID:17686871 RGD:7794851 NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082 		JBrowse link
G Tnf tumor necrosis factor IEP
IMP		 mRNA:increased expression:cornea RGD PMID:10624423 PMID:12162877 RGD:7401196, RGD:8157603 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Immunodeficiency 83 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tlr3 toll-like receptor 3 ISO ClinVar Annotator: match by term: Immunodeficiency 83, susceptibility to viral infections ClinVar
OMIM		 PMID:17872438 PMID:19625408 PMID:20472559 PMID:20855885 PMID:21911422 More... NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16223
    disease by infectious agent 2237
      viral infectious disease 1726
        Viral Skin Diseases 158
          herpes simplex 123
            Febrile Ulceronecrotic Mucha-Habermann Disease 0
            Herpes Labialis 0
            Herpes Simplex Encephalitis + 85
            Herpetic Stomatitis 0
            Neonatal Herpes 0
            eczema herpeticum 2
            genital herpes 9
            herpes simplex virus keratitis + 23
            herpetic whitlow 0
Path 2
Term Annotations click to browse term
  disease 16223
    Pathological Conditions, Signs and Symptoms 12630
      Signs and Symptoms 10508
        Neurologic Manifestations 10166
          sensory system disease 7138
            skin disease 4169
              Infectious Skin Diseases 291
                Viral Skin Diseases 158
                  herpes simplex 123
                    Febrile Ulceronecrotic Mucha-Habermann Disease 0
                    Herpes Labialis 0
                    Herpes Simplex Encephalitis + 85
                    Herpetic Stomatitis 0
                    Neonatal Herpes 0
                    eczema herpeticum 2
                    genital herpes 9
                    herpes simplex virus keratitis + 23
                    herpetic whitlow 0
paths to the root