arthritis - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	arthritis	go back to main search page
Accession:	DOID:848	browse the term
Definition:	A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint. (DO)
Synonyms:	exact_synonym:	Arthritides; Polyarthritides; Polyarthritis; inflammatory disorder of joint
	primary_id:	MESH:D001168
	xref:	EFO:0005856; ICD10CM:M19.90; NCI:C2883
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants Sort by:
Rat (1105) Mouse (941) Human (11114) Chinchilla (838) Bonobo (910) Dog (905) Squirrel (865) Pig (896) Green Monkey (895) Naked Mole-rat (842) All
Genes (932) QTL (118) Strains (55)

arthritis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ANKH inorganic pyrophosphate transport regulator

RGD

NCBI chr 2:78,153,027...78,280,181
Ensembl chr 2:78,153,026...78,280,187

G

beta-2 microglobulin

RGD

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

CD40 molecule

associated with Lupus Erythematosus, Systemic;DNA:SNP: :rs73115010, rs6074028 (human)

RGD

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

Cd69 molecule

CTD Direct Evidence: therapeutic

NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542

G

cannabinoid receptor 2

RGD

NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548

G

collagen type II alpha 1 chain

CTD Direct Evidence: marker/mechanism

PMID:17299831 PMID:24144632 PMID:26640276 PMID:36121554 PMID:37358659

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

COPI coat complex subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr13:84,546,483...84,586,879
Ensembl chr13:84,545,943...84,586,874

G

carnitine palmitoyltransferase 2

ClinVar Annotator: match by term: Arthritis

PMID:7711730 PMID:9600456 PMID:10090476 PMID:12410208 PMID:12673791 More...

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

Fc gamma receptor 3A

susceptibility

associated with Behcet Syndrome; DNA:SNP:exon:p.F158V (rs396991)(human)
DNA:SNP:exon:F158V (rs396991)(human)

RGD

PMID:19026120 PMID:19005160

RGD:5508432, RGD:5508443

NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921

G

GC, vitamin D binding protein

susceptibility

associated with Spondylitis, Ankylosing;DNA:SNPs: :rs222016, rs222020,rs3733359(human)

RGD

NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567

G

haptoglobin

CTD Direct Evidence: marker/mechanism

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

interleukin 23 receptor

susceptibility

associated with Psoriasis;DNA:haplotype::rs7530511, rs11209026(human)

RGD

NCBI chr 4:96,580,568...96,672,540
Ensembl chr 4:96,580,714...96,674,021

G

interferon regulatory factor 5

RGD

NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267

G

poly (ADP-ribose) polymerase 1

associated with Lupus Erythematosus, Systemic;DNA:SNPs:promoter, exon:-1963A>G, p.V762A (40329T>C) (human)

RGD

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

RT1 class II, locus Ba

DNA:polymorphism (human)

RGD

NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744

G

RT1 class II, locus Bb

DNA:polymorphism (human)

RGD

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

G

RT1 class I, locus CE13

associated with Inflammatory Bowel Diseases; DNA:polymorphisms:cds:HLA-B*27, HLA-B*35, HLA-B*44 (human)

RGD

NCBI chr20:3,314,830...3,318,106

G

RT1 class Ib, locus M5

associated with Inflammatory Bowel Diseases;DNA:polymorphisms:cds:multiple (human)

RGD

NCBI chr20:1,546,496...1,548,948
Ensembl chr20:1,546,511...1,548,775

G

selectin E

RGD

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

spleen associated tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410

G

toll-like receptor 4

susceptibility

associated with Behcet Syndrome;DNA:haplotype: :

RGD

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

zinc finger protein 36

CTD Direct Evidence: marker/mechanism

NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564

adult-onset Still's disease

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hepatocyte growth factor

protein:increased expression:serum:

RGD

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

vascular endothelial growth factor A

protein:increased expression:serum:

RGD

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

ankylosing spondylitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

susceptibility

DNA:deletion:intron:IVS16+1464-1751del (human)

RGD

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

adiponectin, C1Q and collagen domain containing

protein:increased expression:serum

RGD

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

anoctamin 6

severity

DNA:SNP: :rs17095830(human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:22138694 PMID:23308121

NCBI chr 7:126,933,919...127,113,588
Ensembl chr 7:126,933,936...127,113,589

G

ANTXR cell adhesion molecule 2

CTD Direct Evidence: marker/mechanism

PMID:20062062 PMID:21743469

NCBI chr14:11,541,718...11,682,110
Ensembl chr14:11,541,772...11,682,094

G

asporin

susceptibility

DNA:repeats:exon:

RGD

NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,080,639...15,104,041

G

caspase recruitment domain family, member 9

CTD Direct Evidence: marker/mechanism

NCBI chr 3:9,171,814...9,180,310
Ensembl chr 3:9,171,815...9,180,237

G

C-reactive protein

disease_progression

protein:increased expression:serum:

RGD

PMID:22422197 PMID:6605119

RGD:6482308, RGD:9491788

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

cytochrome P450, family 1, subfamily a, polypeptide 1

DNA:polymorphism: :4887C>A (human)

RGD

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

endoplasmic reticulum aminopeptidase 1

CTD Direct Evidence: marker/mechanism

PMID:17952073 PMID:20062062 PMID:21743469 PMID:23291587

NCBI chr 2:3,931,817...3,970,735
Ensembl chr 2:3,931,904...3,972,447

G

Fc gamma receptor 3A

severity

protein:decreased expression:polymorphonuclear leucocyte

RGD

NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921

G

insulin-like growth factor binding protein 3

protein:decreased expression:serum

RGD

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

interleukin 12B

CTD Direct Evidence: marker/mechanism

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 17A

treatment

RGD

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 1 receptor type 2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725

G

interleukin 23 receptor

no_association

DNA:SNPs,haplotype:multiple:
CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs11209026(human)

CTD
RGD

PMID:17952073 PMID:20062062 PMID:19522770 PMID:19877036

RGD:8549549, RGD:8549630

NCBI chr 4:96,580,568...96,672,540
Ensembl chr 4:96,580,714...96,674,021

G

interleukin 6

protein:increased expression:serum:

RGD

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin-1 receptor-associated kinase 1

susceptibility

DNA:SNP:enhancer: (rs3027898) (human)

RGD

NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521

G

Janus kinase 2

susceptibility

DNA:SNPs, haplotype:introns: (rs1536798, rs10119004, rs7857730) (human)

RGD

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

lysine demethylase 5A

susceptibility

DNA:snps:intron:IVST>A, IVS-1467C>T, IVS+828T>C (rs7134353, rs2284336, rs11062357) (human)

RGD

NCBI chr 4:153,565,909...153,643,912
Ensembl chr 4:153,565,846...153,642,422

G

methylenetetrahydrofolate reductase

susceptibility

DNA:SNP:cds:677C>T (human)

RGD

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

G

placental growth factor

RGD

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

proteasome 20S subunit beta 9

DNA: snp: rs17587

RGD

NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512

G

prostaglandin E receptor 4

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21743469 PMID:21743469

NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670

G

RT1 class II, locus Ba

severity

DNA:polymorphism:cds:HLA-DQA1*0401 (human)

RGD

NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744

G

RT1 class II, locus Bb

severity

DNA:polymorphism:cds:HLA-DQB1*0603 (human)

RGD

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

G

RT1 class I, locus CE13

susceptibility

DNA:polymorphisms:cds:HLA-B27, HLA-B60 (human, Caucasian)

RGD

NCBI chr20:3,314,830...3,318,106

G

RT1 class II, locus Db1

severity

DNA:polymorphisms:cds:HLA-DRB1*0801, HLA-DRB1*0804 (human)

RGD

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

RT1 class Ib, locus M5

no_association

DNA:polymorphisms:cds:HLA-B2705 (human)

RGD

NCBI chr20:1,546,496...1,548,948
Ensembl chr20:1,546,511...1,548,775

G

RUNX family transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 5:147,360,587...147,419,161
Ensembl chr 5:147,360,994...147,419,156

G

transporter 1, ATP binding cassette subfamily B member

DNA:SNPs: :

RGD

NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901

G

transporter 2, ATP binding cassette subfamily B member

DNA:SNPs: :

RGD

NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407

G

TBK1 binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:82,120,558...82,135,749
Ensembl chr10:82,120,564...82,134,352

G

thrombomodulin

protein:increased expression:serum

RGD

NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193

G

toll-like receptor 4

mRNA:increased expression:blood cell:

RGD

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

toll-like receptor 5

mRNA:increased expression:blood cell:

RGD

NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738

G

TNF receptor superfamily member 1B

RGD

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

vasoactive intestinal peptide

protein:increased expression:plasma

RGD

NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216

autoimmune interstitial lung, joint, and kidney disease

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

atypical chemokine receptor 1

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:85,782,396...85,784,015
Ensembl chr13:85,782,398...85,783,983

G

ADAM metallopeptidase with thrombospondin type 1 motif, 4

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065

G

absent in melanoma 2

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975

G

amyloid P component, serum

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298

G

apolipoprotein A2

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355

G

Rho GTPase activating protein 30

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,822,290...83,843,634
Ensembl chr13:83,822,283...83,854,885

G

activating transcription factor 6

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

ATPase Na+/K+ transporting subunit alpha 2

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATPase Na+/K+ transporting subunit alpha 4

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,683,766...84,719,790
Ensembl chr13:84,683,768...84,719,687

G

beta-1,4-galactosyltransferase 3

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,691,378...83,697,448
Ensembl chr13:83,691,446...83,697,448

G

similar to human chromosome 1 open reading frame 226

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:82,530,589...82,538,676
Ensembl chr13:82,530,577...82,820,949

G

cell adhesion molecule 3

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:85,784,785...85,817,412
Ensembl chr13:85,786,483...85,817,749

G

calsequestrin 1

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,670,648...84,680,339
Ensembl chr13:84,670,649...84,680,339

G

CD244 molecule

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,051,339...84,082,864
Ensembl chr13:84,052,493...84,074,492

G

Cd48 molecule

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,184,884...84,209,144
Ensembl chr13:84,185,532...84,209,142

G

CD84 molecule

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076

G

cilia and flagella associated protein 126

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,526,657...83,542,552
Ensembl chr13:83,526,657...83,542,552

G

cilia and flagella associated protein 45

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,989,474...85,012,880
Ensembl chr13:84,981,728...85,012,878

G

COPI coat complex subunit alpha

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome | ClinVar Annotator: match by term: Autoimmune interstitial lung, joint, and kidney disease
OMIM:616414

OMIM
ClinVar
MouseDO

PMID:9536098 PMID:17576681 PMID:25741868 PMID:25894502 PMID:27048656 More...

NCBI chr13:84,546,483...84,586,879
Ensembl chr13:84,545,943...84,586,874

G

C-reactive protein

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

DDB1 and CUL4 associated factor 8

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,609,838...84,667,025
Ensembl chr13:84,610,248...84,669,726

G

discoidin domain receptor tyrosine kinase 2

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

death effector domain-containing

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,755,874...83,769,982
Ensembl chr13:83,756,108...83,769,332

G

dual specificity phosphatase 12

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,122,192...83,131,800
Ensembl chr13:83,122,193...83,131,285

G

dual specificity phosphatase 23

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:85,097,899...85,100,054
Ensembl chr13:85,097,899...85,100,093

G

F11 receptor

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402

G

Fc epsilon receptor Ia

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351

G

Fc epsilon receptor Ig

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443

G

Fc gamma receptor 2A

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967

G

Fc gamma receptor 2B

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778

G

Fc gamma receptor 3A

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921

G

Fc receptor-like 6

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:85,062,709...85,072,308
Ensembl chr13:85,066,694...85,072,600

G

Fc receptor-like A

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,160,453...83,170,170
Ensembl chr13:83,160,398...83,170,762

G

Fc receptor-like B

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,148,685...83,157,157
Ensembl chr13:83,149,751...83,155,957

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,273,176...83,274,317

G

immunoglobulin superfamily, member 8

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,770,348...84,781,534
Ensembl chr13:84,770,279...84,778,576

G

immunoglobulin superfamily, member 9

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,948,643...84,965,616
Ensembl chr13:84,948,619...84,965,607

G

intelectin 1

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,932,234...83,958,243
Ensembl chr13:83,948,124...83,958,227

G

potassium inwardly-rectifying channel, subfamily J, member 10

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,802,026...84,835,383
Ensembl chr13:84,802,009...84,835,461

G

potassium inwardly-rectifying channel, subfamily J, member 9

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,780,826...84,787,928
Ensembl chr13:84,779,741...84,787,928

G

kelch domain containing 9

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,790,390...83,794,080
Ensembl chr13:83,790,269...83,793,354

G

lymphocyte antigen 9

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,079,345...84,100,783
Ensembl chr13:84,079,458...84,100,823

G

myeloid cell nuclear differentiation antigen

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:86,017,888...86,035,556
Ensembl chr13:86,017,892...86,034,201

G

myelin protein zero

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,570,811...83,576,680
Ensembl chr13:83,570,811...83,576,679

G

nicastrin

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454

G

NADH:ubiquinone oxidoreductase core subunit S2

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420

G

nectin cell adhesion molecule 4

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,802,589...83,821,711
Ensembl chr13:83,803,184...83,821,709

G

nescient helix loop helix 1

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,517,347...84,522,548
Ensembl chr13:84,517,289...84,525,094

G

nitrilase 1

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,769,888...83,773,324
Ensembl chr13:83,765,941...83,773,332

G

NLR family, pyrin domain containing 12

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

PMID:25741868 PMID:28492532

NCBI chr 1:65,932,610...65,969,873
Ensembl chr 1:65,932,595...65,960,934

G

nitric oxide synthase 1 adaptor protein

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:82,547,799...82,820,999
Ensembl chr13:82,530,577...82,820,949

G

nuclear receptor subfamily 1, group I, member 3

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

olfactomedin-like 2B

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:82,869,414...82,906,607
Ensembl chr13:82,869,433...82,906,607

G

olfactory receptor family 10 subfamily J member 2

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:85,723,300...85,724,290
Ensembl chr13:85,719,234...85,724,767

G

olfactory receptor family 10 subfamily J member 3

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:85,667,254...85,668,195
Ensembl chr13:85,662,666...85,669,540

G

olfactory receptor family 10 subfamily J member 5

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:85,430,655...85,431,584
Ensembl chr13:85,424,254...85,432,107

G

olfactory receptor family 6 subfamily K member 2

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:86,186,442...86,190,391
Ensembl chr13:86,185,529...86,190,815

G

olfactory receptor family 6 subfamily K member 14B

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:86,164,244...86,165,191
Ensembl chr13:86,160,158...86,166,214

G

olfactory receptor family 6 subfamily K member 6

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:86,148,402...86,149,325
Ensembl chr13:86,147,303...86,152,153

G

olfactory receptor family 6 subfamily N member 1

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:86,106,912...86,107,850
Ensembl chr13:86,102,080...86,108,363

G

olfactory receptor family 6 subfamily N member 2

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:86,076,857...86,087,100

G

Purkinje cell protein 4-like 1

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,588,992...83,612,631
Ensembl chr13:83,588,992...83,609,966

G

proliferation and apoptosis adaptor protein 15

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499

G

peroxisomal biogenesis factor 19

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,592,277...84,608,793
Ensembl chr13:84,592,312...84,608,608

G

prefoldin subunit 2

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,772,301...83,791,367
Ensembl chr13:83,753,877...83,790,504

G

phosphatidylinositol glycan anchor biosynthesis, class M

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,838,329...84,842,026
Ensembl chr13:84,838,175...84,843,381

G

protoporphyrinogen oxidase

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,697,661...83,701,998
Ensembl chr13:83,664,891...83,701,805

G

succinate dehydrogenase complex subunit C

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253

G

SH2 domain containing 1B

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:82,485,076...82,519,401

G

signaling lymphocytic activation molecule family member 1

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,270,316...84,305,497
Ensembl chr13:84,270,316...84,305,497

G

SLAM family member 6

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,384,561...84,405,300
Ensembl chr13:84,383,742...84,405,300

G

SLAM family member 7

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,135,656...84,154,528
Ensembl chr13:84,136,899...84,154,105

G

SLAM family member 8

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:85,047,729...85,057,571
Ensembl chr13:85,047,727...85,057,211

G

SLAM family member 9

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,941,896...84,944,749
Ensembl chr13:84,941,982...84,944,748

G

spermatogenesis associated 46

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:82,541,183...82,544,808
Ensembl chr13:82,541,183...82,544,808

G

spectrin, alpha, erythrocytic 1

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:86,203,504...86,279,371
Ensembl chr13:86,203,504...86,279,371

G

transgelin 2

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972

G

translocase of outer mitochondrial membrane 40 like

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,636,692...83,641,654
Ensembl chr13:83,638,195...83,641,654

G

thiosulfate sulfurtransferase like domain containing 1

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,853,421...83,854,875
Ensembl chr13:83,822,035...83,854,885

G

UDP-N-acetylglucosamine pyrophosphorylase 1

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:82,342,946...82,377,558
Ensembl chr13:82,342,946...82,377,469

G

ubiquitin-fold modifier conjugating enzyme 1

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,709,329...83,719,762
Ensembl chr13:83,709,330...83,716,076

G

U2AF homology motif kinase 1

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:82,396,646...82,416,292
Ensembl chr13:82,401,187...82,416,292

G

upstream transcription factor 1

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,845,230...83,854,875
Ensembl chr13:83,822,035...83,854,885

G

ubiquitin specific peptidase 21

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:83,702,672...83,709,215
Ensembl chr13:83,702,631...83,708,717

G

VANGL planar cell polarity protein 2

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:84,462,731...84,489,404
Ensembl chr13:84,465,527...84,489,378

G

V-set and immunoglobulin domain containing 8

ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome

NCBI chr13:85,023,177...85,031,364
Ensembl chr13:85,023,177...85,031,364

Autoinflammation with Arthritis and Dyskeratosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

NLR family, pyrin domain containing 1A

ClinVar Annotator: match by term: Autoinflammation with arthritis and dyskeratosis

PMID:16918630 PMID:17377159 PMID:24033266 PMID:25741868 PMID:27965258 More...

NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180

Autosomal Dominant Tubulointerstitial Kidney Disease 1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

uromodulin

ClinVar Annotator: match by term: Glomerulocystic kidney disease with hyperuricemia and isosthenuria | ClinVar Annotator: match by term: Medullary cystic kidney disease 2 | ClinVar Annotator: match by term: Medullary cystic kidney disease 2, autosomal dominant | ClinVar Annotator: match by term: TUBULOINTERSTITIAL KIDNEY DISEASE, AUTOSOMAL DOMINANT, 1 | ClinVar Annotator: match by term: UMOD-Associated Kidney Disease | ClinVar Annotator: match by term: UMOD-related condition | ClinVar Annotator: match by term: Uromodulin-associated kidney disease

ClinVar
OMIM
RGD

PMID:7396593 PMID:9536098 PMID:10330352 PMID:12205338 PMID:12471200 More...

NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302

Beukes hip dysplasia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ankyrin repeat domain 37

ClinVar Annotator: match by term: Hip dysplasia, Beukes type

NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963

G

cilia and flagella associated protein 96

ClinVar Annotator: match by term: Hip dysplasia, Beukes type | ClinVar Annotator: match by term: Osteoarthropathy, premature degenerative, of hip

PMID:25741868 PMID:28492532 PMID:33473208

NCBI chr16:46,291,075...46,315,616
Ensembl chr16:46,291,311...46,315,625

G

UFM1-specific peptidase 2

ClinVar Annotator: match by term: Hip dysplasia, Beukes type | ClinVar Annotator: match by term: Osteoarthropathy, premature degenerative, of hip
CTD Direct Evidence: marker/mechanism

OMIM
ClinVar
CTD

PMID:2389793 PMID:21228277 PMID:25741868 PMID:26428751 PMID:28492532 More...

NCBI chr16:46,272,016...46,291,080
Ensembl chr16:46,272,016...46,291,059

Blau syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CYLD lysine 63 deubiquitinase

ClinVar Annotator: match by term: Blau syndrome

NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658

G

nucleotide-binding oligomerization domain containing 2

susceptibility

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Blau syndrome | ClinVar Annotator: match by term: Jabs syndrome
DNA:snps:cds:p.R587C, p.C495Y, p.W490L (human)
DNA:snp:cds:p.E383K (human)
DNA:snp:cds:p.E383G (human)
DNA:snps:cds:p.R334Q, p.R334W, p.L469F (human)

OMIM
CTD
ClinVar
RGD

PMID:7825454 PMID:9124059 PMID:9536098 PMID:11385576 PMID:11385577 More...

RGD:8547518, RGD:8547515, RGD:8158051, RGD:8158040

NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177

G

spalt-like transcription factor 1

ClinVar Annotator: match by term: Blau syndrome

NCBI chr19:18,005,782...18,022,705
Ensembl chr19:18,007,503...18,022,705

chondrocalcinosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ANKH inorganic pyrophosphate transport regulator

ClinVar Annotator: match by term: Chondrocalcinosis

PMID:25741868 PMID:12297987

NCBI chr 2:78,153,027...78,280,181
Ensembl chr 2:78,153,026...78,280,187

G

OTU deubiquitinase with linear linkage specificity

ClinVar Annotator: match by term: Chondrocalcinosis

NCBI chr 2:78,290,437...78,316,633
Ensembl chr 2:78,290,959...78,316,422

G

proopiomelanocortin

CTD Direct Evidence: therapeutic

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

Chondrocalcinosis 2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ANKH inorganic pyrophosphate transport regulator

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: ANKH-related condition | ClinVar Annotator: match by term: Chondrocalcinosis 2

OMIM
CTD
ClinVar

PMID:2712793 PMID:8528213 PMID:9915952 PMID:11326272 PMID:12297987 More...

NCBI chr 2:78,153,027...78,280,181
Ensembl chr 2:78,153,026...78,280,187

G

OTU deubiquitinase with linear linkage specificity

ClinVar Annotator: match by term: ANKH-related condition | ClinVar Annotator: match by term: Chondrocalcinosis 2

PMID:2712793 PMID:11326272 PMID:19449425 PMID:25741868 PMID:28492532

NCBI chr 2:78,290,437...78,316,633
Ensembl chr 2:78,290,959...78,316,422

Digital Arthropathy-Brachydactyly, Familial

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

transient receptor potential cation channel, subfamily V, member 4

ClinVar Annotator: match by term: Familial digital arthropathy-brachydactyly
CTD Direct Evidence: marker/mechanism

OMIM
ClinVar
CTD

PMID:4056805 PMID:8179305 PMID:11891693 PMID:20037586 PMID:20037587 More...

NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517

Experimental Arthritis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

protein:increased expression:serum

RGD

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

ATP binding cassette subfamily B member 1A

mRNA:altered expression:liver
CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:intestinal mucosa (rat)

CTD
RGD

PMID:17827786 PMID:19152228 PMID:17827786

RGD:2315573, RGD:11040994

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 6

mRNA:decreased expression:kidney

RGD

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

G

ATP binding cassette subfamily G member 2

mRNA:decreased expression:small intestine

RGD

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

aggrecan

treatment

RGD

NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627

G

angiotensin I converting enzyme

RGD

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

acyl-CoA synthetase long-chain family member 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

acyl-CoA synthetase long-chain family member 4

CTD Direct Evidence: marker/mechanism

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

acyl-CoA synthetase long-chain family member 5

CTD Direct Evidence: marker/mechanism

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

G

ADAM metallopeptidase domain 10

RGD

NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889

G

ADAM metallopeptidase domain 17

RGD

NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639

G

adiponectin, C1Q and collagen domain containing

protein:increased expression:serum
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:23326410 PMID:21681567 PMID:19026984

RGD:5685385, RGD:5686814

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adenosine kinase

RGD

NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510

G

adenosylhomocysteinase

RGD

NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393

G

aryl hydrocarbon receptor

exacerbates

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:25194622 PMID:26221077 PMID:27032495

RGD:405878089, RGD:407420267

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

AKT serine/threonine kinase 1

treatment

RGD

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

CTD Direct Evidence: marker/mechanism

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

arachidonate 15-lipoxygenase

RGD

NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874

G

annexin A1

RGD

PMID:10403283 PMID:23267026

RGD:2306928, RGD:7421573

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A2

ameliorates

RGD

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

amine oxidase, copper containing 3

RGD

NCBI chr10:86,272,757...86,280,702

G

apolipoprotein A4

protein:decreased expression:blood serum (rat)

RGD

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

arrestin, beta 1

protein:increased expression:knee, synoviocyte (rat)

RGD

NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061

G

arrestin, beta 2

protein:increased expression:knee, synoviocyte (rat)

RGD

NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850

G

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

RGD

NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889

G

BCL2 associated X, apoptosis regulator

treatment

RGD

PMID:21199477 PMID:22978269

RGD:10054249, RGD:10054498

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

treatment

RGD

PMID:21199477 PMID:22978269

RGD:10054249, RGD:10054498

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bradykinin receptor B1

RGD

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

bone gamma-carboxyglutamate protein

protein:decreased expression:serum

RGD

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

Bruton tyrosine kinase

treatment

RGD

PMID:22228807 PMID:32083858

RGD:11040701, RGD:151665122

NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853

G

complement C3

treatment

RGD

PMID:20051658 PMID:7347767

RGD:7411688, RGD:11041098

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C5

RGD

PMID:20975959 PMID:12355496

RGD:5130175, RGD:1600637

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

calcineurin binding protein 1

RGD

NCBI chr20:12,893,314...13,015,357
Ensembl chr20:12,893,358...13,015,357

G

calcitonin-related polypeptide alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

catalase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

Cbl proto-oncogene

treatment

RGD

NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176

G

Cbl proto-oncogene B

RGD

NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839

G

C-C motif chemokine ligand 2

treatment

mRNA, protein:increased expression:synovium

RGD

PMID:18292571 PMID:24583103 PMID:17052673 PMID:18726678

RGD:2307052, RGD:11526142, RGD:2307143, RGD:2307008

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

mRNA, protein:increased expression:synovium, monocytes

RGD

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 5

mRNA, protein:increased expression:synovium, monocytes

RGD

PMID:9637726 PMID:17052673

RGD:4889940, RGD:2307143

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

onset

RGD

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

cellular communication network factor 1

ameliorates

RGD

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

C-C motif chemokine receptor 1

RGD

PMID:18608173 PMID:14674010

RGD:5688144, RGD:1582346

NCBI chr 8:123,556,286...123,561,841

G

C-C motif chemokine receptor 2

RGD

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

C-C motif chemokine receptor 5

treatment

mRNA:increased expression:ankle (rat)

RGD

PMID:14674010 PMID:22289897

RGD:1582346, RGD:5687744

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

G

Cd28 molecule

RGD

NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685

G

Cd4 molecule

treatment

RGD

PMID:15479897 PMID:12010568

RGD:10058957, RGD:10058960

NCBI chr 4:157,668,878...157,695,366

G

CD40 molecule

RGD

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD40 ligand

treatment

protein:increased expression:plasma (rat)

RGD

PMID:27218142 PMID:7689748 PMID:22611405

RGD:11344958, RGD:11352696, RGD:11352298

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

CD44 molecule

protein:increased expression:joint, macrophage, lymphocyte

RGD

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

CD46 molecule

RGD

NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445

G

CD59b molecule

RGD

NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847

G

Cd69 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542

G

Cd80 molecule

RGD

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

cell division cycle 42

protein:increased activation:bone marrow, macrophage

RGD

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

G

cyclin-dependent kinase inhibitor 2A

treatment

RGD

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

complement factor H

RGD

NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838

G

collagen type II alpha 1 chain

CTD Direct Evidence: marker/mechanism

PMID:16200597 PMID:21188452 PMID:23326410 PMID:24709313 PMID:25194622 More...

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

ceruloplasmin

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:19330884 PMID:19205849

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

coproporphyrinogen oxidase

protein:decreased activity:liver (rat)

RGD

NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746

G

corticotropin releasing hormone receptor 1

RGD

NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481

G

C-reactive protein

CTD Direct Evidence: marker/mechanism

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

colony stimulating factor 1

protein:increased expression:dorsal root ganglion

RGD

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

colony stimulating factor 1 receptor

treatment

RGD

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

colony stimulating factor 3

treatment

RGD

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

C-terminal Src kinase

RGD

NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292

G

cytotoxic T-lymphocyte-associated protein 4

treatment

RGD

PMID:22354915 PMID:7543497

RGD:7204500, RGD:7204519

NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963

G

cathepsin B

mRNA:increased expression:knee joint, synovium (rat)

RGD

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin K

mRNA:increased expression:synovium, bone marrow

RGD

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cathepsin S

RGD

NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483

G

C-X3-C motif chemokine ligand 1

RGD

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X3-C motif chemokine receptor 1

protein:increased expression:spinal cord

RGD

PMID:17123734 PMID:11465708

RGD:4891969, RGD:4892002

NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014

G

C-X-C motif chemokine ligand 1

RGD

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 6

severity

RGD

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

discoidin domain receptor tyrosine kinase 2

ameliorates

RGD

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

dihydroorotate dehydrogenase (quinone)

RGD

NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654

G

deoxyribonuclease 2, lysosomal

CTD Direct Evidence: marker/mechanism

NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376

G

DNA methyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

dopamine receptor D1

treatment

mRNA:increased expression:corpus striatum (rat)

RGD

PMID:23762129 PMID:23762129

RGD:7248592, RGD:7248592

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

treatment

mRNA:increased expression:corpus striatum (rat)

RGD

PMID:23762129 PMID:23762129

RGD:7248592, RGD:7248592

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

endothelin 1

mRNA:increased expression:inguinal lymph node (mouse)

RGD

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

epidermal growth factor receptor

CTD Direct Evidence: therapeutic

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

estrogen receptor 1

treatment

associated with Osteoporosis

RGD

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

RGD

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

coagulation factor II, thrombin

RGD

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

coagulation factor II (thrombin) receptor

severity

RGD

NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870

G

F2R like trypsin receptor 1

RGD

NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226

G

Fas ligand

treatment

RGD

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

Fc gamma receptor 1A

protein:increased expression:dorsal root ganglion
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12875993 PMID:16670289 PMID:32510872

RGD:9685708, RGD:127338469

NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994

G

Fc gamma receptor 2A

onset

RGD

PMID:18354234 PMID:16623928

RGD:5508446, RGD:5508457

NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967

G

Fc gamma receptor 2B

RGD

NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778

G

fibroblast growth factor 8

RGD

NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359

G

Fibroblast growth factor receptor 1

RGD

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

Fms related receptor tyrosine kinase 1

RGD

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

Fms related receptor tyrosine kinase 3

RGD

NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474

G

Fos proto-oncogene, AP-1 transcription factor subunit

treatment

RGD

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box P3

treatment

mRNA,protein:decreased expression:lung

RGD

PMID:29264841 PMID:23643080

RGD:38549364, RGD:38599003

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

gap junction protein, alpha 1

RGD

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

GLI family zinc finger 1

treatment

RGD

NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251

G

glucose-6-phosphate isomerase

RGD

NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086

G

G protein-coupled receptor kinase 2

treatment
disease_progression

protein:increased expression:aorta (rat)
protein:altered expression:T cell (rat)

RGD

PMID:28653218 PMID:28631356 PMID:28349925

RGD:13513975, RGD:13513976, RGD:13513979

NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582

G

granulin precursor

RGD

NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775

G

glycogen synthase kinase 3 beta

CTD Direct Evidence: marker/mechanism

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glucuronidase, beta

treatment

RGD

NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905

G

hepatitis A virus cellular receptor 2

mRNA,protein:altered expression:bone:

RGD

NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137

G

histone deacetylase 6

treatment

RGD

NCBI chr X:14,550,645...14,572,445
Ensembl chr X:14,551,044...14,572,441

G

hypoxia inducible factor 1 subunit alpha

treatment

RGD

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

high mobility group box 1

protein:altered localization:cytoplasm, extracellular matrix

RGD

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

3-hydroxy-3-methylglutaryl-CoA reductase

RGD

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

haptoglobin

mRNA, protein:increased expression:tendon, ankle
protein:increased expression:serum

RGD

PMID:12801280 PMID:15899029

RGD:1626375, RGD:1626370

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

heat shock protein family D (Hsp60) member 1

RGD

PMID:15529360 PMID:10882416

RGD:1624244, RGD:12910542

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

interferon gamma

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:19203382 PMID:22450443 PMID:12412757 PMID:7774621

RGD:2311498, RGD:10755750

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

protein:decreased expression:plasma

RGD

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein 3

mRNA, protein:increased expression:kidney, serum

RGD

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

inhibitor of nuclear factor kappa B kinase subunit beta

treatment

RGD

PMID:21087862 PMID:19652024

RGD:7495772, RGD:7495778

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

treatment

RGD

NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499

G

interleukin 10

treatment

CTD Direct Evidence: marker/mechanism|therapeutic
protein:decreased expression:serum:

CTD
RGD

PMID:20974942 PMID:22450443 PMID:19193354 PMID:19169271 PMID:23140046 More...

RGD:2311059, RGD:8662976, RGD:7193038, RGD:7364838, RGD:1626677

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

treatment

CTD Direct Evidence: therapeutic

CTD
RGD

PMID:10444273 PMID:17665443 PMID:11860705

RGD:4889497, RGD:8549606

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 15

RGD

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

G

interleukin 17A

treatment

IMP
ISO
IEP
IDA

CTD Direct Evidence: marker/mechanism
protein:increased expression:serum (rat)

CTD
RGD

PMID:20974942 PMID:20925596 PMID:23377547 PMID:21194185 PMID:20925596

RGD:4781444, RGD:9130803, RGD:9068936, RGD:4781444

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

disease_progression

RGD

PMID:19096963 PMID:15147345

RGD:4889415, RGD:4889503

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

protein:increased expression:serum:

RGD

PMID:20379758 PMID:19169271

RGD:6907373, RGD:8662976

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

treatment

CTD Direct Evidence: marker/mechanism
protein:increased expression:serum (rat)

CTD
RGD

PMID:19330884 PMID:20131233 PMID:20974942 PMID:22450443 PMID:21557995 More...

RGD:7175317, RGD:13792834, RGD:10755447, RGD:7193038

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 1 receptor antagonist

treatment

rat model treated with human protein
human gene in a rat model
mRNA:increased expression:popliteal lymph node (rat)
mouse model treated with human protein

RGD

PMID:15270736 PMID:12727108 PMID:10921508 PMID:22267332 PMID:23006786

RGD:1626677, RGD:8551745, RGD:8551741, RGD:8549801, RGD:6907376

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 2

treatment

protein:increased expression:serum:

RGD

PMID:19169271 PMID:2492102

RGD:8662976, RGD:10047055

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 20

RGD

NCBI chr13:42,380,981...42,384,625
Ensembl chr13:42,380,981...42,384,625

G

interleukin 2 receptor subunit alpha

RGD

NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697

G

interleukin 33

CTD Direct Evidence: marker/mechanism

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

G

interleukin 4

treatment

CTD Direct Evidence: therapeutic

CTD
RGD

PMID:10444273 PMID:16869003 PMID:23972727 PMID:23140046

RGD:2317300, RGD:10402790, RGD:7193038

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

treatment

IEP
ISO
IDA
IMP

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20131233 PMID:20974942 PMID:22450443 PMID:24028507 PMID:8607900 More...

RGD:10755447, RGD:11060267, RGD:11049553, RGD:11049551

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 cytokine family signal transducer

RGD

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

G

integrin subunit alpha 4

treatment

RGD

NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715

G

integrin subunit beta 2

RGD

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

integrin subunit beta 3

protein:increased expression:endothelial cell

RGD

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

jagged canonical Notch ligand 1

RGD

NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209

G

Janus kinase 1

treatment

RGD

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 2

treatment

RGD

PMID:22339472 PMID:23711144 PMID:22800927

RGD:10403066, RGD:10403081, RGD:10403074

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Janus kinase 3

treatment

RGD

PMID:25762693 PMID:18234077 PMID:21434883

RGD:11533938, RGD:11533944, RGD:11533942

NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536

G

potassium calcium-activated channel subfamily N member 4

ameliorates

RGD

NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340

G

kallikrein B1

RGD

PMID:22739815 PMID:9783057

RGD:7297047, RGD:7327138

NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053

G

kininogen 2

peptidoglycan-polysaccharide-induced arthritis in Lewis rats

RGD

PMID:9214434 PMID:1996642

RGD:1600547, RGD:11059895

NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971

G

kynurenine aminotransferase 1

RGD

NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355

G

leptin

CTD Direct Evidence: marker/mechanism

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

galectin 3

RGD

NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025

G

mitogen-activated protein kinase kinase kinase 5

RGD

NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800

G

macrophage migration inhibitory factor

RGD

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504

G

microRNA 146a

mRNA:increased expression:joints (mouse)

RGD

NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610

G

microRNA 152

CTD Direct Evidence: marker/mechanism
miRNA:decreased exression:synovial membrane of synovial joint

CTD
RGD

PMID:25194984 PMID:25194984

NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020

G

microRNA 23b

treatment

mRNA:decreased expression:joint (mouse)

PMID:22660635 PMID:22660635

RGD:155663483, RGD:155663483

NCBI chr17:1,813,667...1,813,763
Ensembl chr17:1,813,667...1,813,763

G

microRNA 26a

CTD Direct Evidence: therapeutic

NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378

G

matrix metallopeptidase 1

RGD

PMID:21288455 PMID:24011916 PMID:21108488

RGD:7207362, RGD:8549748, RGD:7207365

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 13

treatment

RGD

PMID:24244039 PMID:11435459

RGD:8694124, RGD:1582329

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 3

treatment

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:ankle joint

CTD
RGD

PMID:20974942 PMID:20703013 PMID:24244039 PMID:24244039 PMID:24011916 More...

RGD:7241231, RGD:8694124, RGD:8694124, RGD:8549748, RGD:8693318

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

protein:increased expression:cartilage, serum, synovial fluid

RGD

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

CTD Direct Evidence: marker/mechanism

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mitochondrially encoded ATP synthase membrane subunit 8

susceptibility

DNA:transversion: :m.7778G>T (mouse)

RGD

NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961

G

mechanistic target of rapamycin kinase

treatment

RGD

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYD88, innate immune signal transduction adaptor

RGD

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

myogenic differentiation 1

treatment

RGD

NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554

G

myogenin

treatment

RGD

NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039

G

neutrophil cytosolic factor 1

severity

DNA:missense mutations:cds:p.M106V, p.M153T (rat)

RGD

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

nucleotide-binding oligomerization domain containing 2

RGD

PMID:21424514 PMID:20131263

RGD:5508728, RGD:8552884

NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177

G

nitric oxide synthase 2

protein:increased expression:ankle joint (mouse)

RGD

PMID:12826065 PMID:21880869

RGD:1358527, RGD:5509060

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

treatment

RGD

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

neuropeptide S receptor 1

treatment

RGD

NCBI chr 8:22,606,946...22,831,558
Ensembl chr 8:22,606,946...22,831,558

G

NAD(P)H quinone dehydrogenase 1

severity

RGD

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group H, member 2

RGD

NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377

G

nuclear receptor subfamily 1, group H, member 3

RGD

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

G

NRAS proto-oncogene, GTPase

RGD

NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626

G

neurotensin

RGD

NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423

G

orosomucoid 1

protein:increased expression:liver

RGD

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

purinergic receptor P2Y12

RGD

NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361

G

peptidylglycine alpha-amidating monooxygenase

RGD

NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965

G

poly (ADP-ribose) polymerase 1

severity

RGD

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

prodynorphin

treatment

RGD

NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334

G

platelet and endothelial cell adhesion molecule 1

severity

protein:increased expression:knee joint, blood vessels (mouse)

RGD

PMID:22548760 PMID:14613294 PMID:21982514

RGD:6484738, RGD:6771222, RGD:6771177

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

placental growth factor

RGD

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta

RGD

NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

RGD

PMID:20374644 PMID:18412166

RGD:6482684, RGD:6482696

NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043

G

plasminogen activator, urokinase

RGD

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

proopiomelanocortin

treatment

RGD

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

PR/SET domain 1

CTD Direct Evidence: therapeutic

NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488

G

patched 1

treatment

RGD

NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333

G

prostaglandin E receptor 4

treatment
disease_progression

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:tarsal joint, synovium (rat)

CTD
RGD

PMID:18287210 PMID:20423341 PMID:11207665 PMID:18287210

RGD:10003041, RGD:10043377, RGD:10003052

NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670

G

prostaglandin E synthase

mRNA, protein:increased expression:paw

RGD

NCBI chr 3:14,177,892...14,189,236

G

prostaglandin E synthase 3

mRNA:increased expression:paw (rat)

RGD

NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084

G

prostaglandin-endoperoxide synthase 1

mRNA, protein:increased expression:synovium

RGD

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

mRNA, protein:increased expression:synovium
protein:increased expression:autopod joint

RGD

PMID:18758904 PMID:22289897 PMID:21765105

RGD:2300221, RGD:5687744, RGD:5508310

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 22

protein:increased expression:metatarsophalangeal joint, mononuclear cell (rat)

RGD

NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779

G

recombination activating 2

CTD Direct Evidence: therapeutic

NCBI chr 3:87,902,373...87,910,227
Ensembl chr 3:87,902,238...87,911,066

G

RT1 class II, locus Db1

RGD

PMID:21665435 PMID:19950279

RGD:5147558, RGD:5147586

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

S100 calcium binding protein A8

RGD

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein A9

RGD

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

serpin family C member 1

protein:decreased expression:plasma

RGD

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

secreted frizzled-related protein 4

CTD Direct Evidence: marker/mechanism

NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736

G

sonic hedgehog signaling molecule

treatment

RGD

NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170

G

solute carrier family 11 member 1

severity

RGD

NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101

G

secretory leukocyte peptidase inhibitor

treatment

protein:decreased expression:articular cartilage of joint

RGD

PMID:10449524 PMID:9744360

RGD:634208, RGD:9999431

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

smoothened, frizzled class receptor

treatment

RGD

NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829

G

suppressor of cytokine signaling 3

mRNA:increased expression:mononuclear cell

RGD

NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787

G

sialophorin

associated with Staphylococcal Infections

RGD

NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628

G

signal transducer and activator of transcription 1

protein:increased tyrosine phosphorylation:macrophage, synovial cell
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:15188379 PMID:14674010

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:15188379 PMID:21937456 PMID:23711144

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

tachykinin, precursor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

transforming growth factor, beta 1

RGD

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 2

protein:increased expression:synovium

RGD

NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228

G

thrombomodulin

RGD

NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193

G

TIMP metallopeptidase inhibitor 4

RGD

NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558

G

tight junction protein 1

RGD

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

toll-like receptor 2

RGD

PMID:21725847 PMID:20131263

RGD:7241099, RGD:8552884

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 3

mRNA, protein:increased expression:spleen (rat)

RGD

PMID:20500834 PMID:20500834

RGD:5128706, RGD:5128706

NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545

G

tumor necrosis factor

treatment

CTD Direct Evidence: marker/mechanism
protein:increased expression:serum:

CTD
RGD

PMID:7589090 PMID:9598899 PMID:19203382 PMID:19330884 PMID:19765281 More...

RGD:7245941, RGD:13792834, RGD:10755447, RGD:10450611, RGD:8662976, RGD:8661761, RGD:7193038

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 11B

treatment

mRNA:decreased expression:bone
Sinomenine CHEBI:9163
CTD Direct Evidence: therapeutic

CTD
RGD

PMID:23333834 PMID:16696922 PMID:24066131

RGD:1624171, RGD:42721982

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF receptor superfamily member 1A

treatment

RGD

PMID:23052485 PMID:21690068 PMID:20370892

RGD:7245941, RGD:8661761, RGD:8661729

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

treatment

human protein in rat model

RGD

PMID:21463515 PMID:21690068 PMID:23052485

RGD:5131255, RGD:8661761, RGD:7245941

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

transient receptor potential cation channel, subfamily V, member 2

treatment

RGD

NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260

G

thioredoxin domain containing 5

CTD Direct Evidence: marker/mechanism

NCBI chr17:26,289,880...26,318,025
Ensembl chr17:26,289,880...26,318,025

G

vascular endothelial growth factor A

CTD Direct Evidence: marker/mechanism

PMID:9598899 PMID:26221077

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

RGD

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

vasoactive intestinal peptide

RGD

PMID:21998117 PMID:19055696

RGD:5685376, RGD:5685612

NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216

G

xanthine dehydrogenase

protein:increased expression:brain, mitochondrion

RGD

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

G

xylosyltransferase 1

mRNA:decreased expression:articular cartilage

RGD

NCBI chr 1:171,643,925...171,929,774
Ensembl chr 1:171,643,925...171,926,783

gout

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

APOBEC1 complementation factor

DNA:SNP: :rs10821905 (human)

RGD

PMID:28679452 PMID:28252667

RGD:13831119, RGD:13831120

NCBI chr 1:229,736,037...229,823,499
Ensembl chr 1:229,736,106...229,824,354

G

ATP binding cassette subfamily G member 2

susceptibility

DNA:SNP:exon:rs2231142(human)
ClinVar Annotator: match by term: GOUT SUSCEPTIBILITY 1
CTD Direct Evidence: marker/mechanism

ClinVar
CTD
OMIM
RGD

PMID:16702730 PMID:16784736 PMID:18834626 PMID:19474787 PMID:19506252 More...

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

adrenoceptor beta 3

DNA:missense mutation:cds:p.W64R rs4994 (human)

RGD

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

aldehyde dehydrogenase 16 family, member A1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:95,626,727...95,639,808
Ensembl chr 1:95,613,558...95,640,131

G

alpha-kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:216,126,939...216,247,180
Ensembl chr 2:216,128,825...216,247,157

G

CD14 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

aspartyl-tRNA synthetase 2 (mitochondrial)

ClinVar Annotator: match by term: Gout

PMID:16199547 PMID:17384640 PMID:19592391 PMID:22843165 PMID:23065766 More...

NCBI chr13:73,308,726...73,336,558
Ensembl chr13:73,308,726...73,336,934

G

haptoglobin

RGD

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

interleukin 1 beta

CTD Direct Evidence: marker/mechanism

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

CTD Direct Evidence: therapeutic

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 33

RGD

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

G

phosphoribosyl pyrophosphate synthetase 1

N113S, D182H

NCBI chr X:104,132,139...104,154,191
Ensembl chr X:104,132,141...104,154,187

G

solute carrier family 17 member 3

ClinVar Annotator: match by term: GOUT SUSCEPTIBILITY 4

NCBI chr17:41,270,804...41,300,132
Ensembl chr17:41,270,812...41,295,256

G

solute carrier family 2 member 9

CTD Direct Evidence: marker/mechanism

PMID:18327256 PMID:18327257

NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981

G

transforming growth factor, beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

xanthine dehydrogenase

CTD Direct Evidence: marker/mechanism

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

Gouty Arthritis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

matrix metallopeptidase 2

severity

RGD

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

RGD

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

severity

RGD

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

proopiomelanocortin

CTD Direct Evidence: therapeutic

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

Hand Osteoarthritis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

estrogen receptor 1

no_association

DNA:SNPs:exons: (rs2077647, rs1801132) (human)

RGD

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

no_association

DNA:SNPs:introns: (rs1256034, rs1256059, rs944460) (human)

RGD

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

interleukin 4

no_association

DNA:SNPs:promoter, 5' utr, intron:multiple

RGD

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 4 receptor

no_association

DNA:SNPs:promoter, exons:multiple

RGD

NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980

HRPT-related hyperuricemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldehyde dehydrogenase 16 family, member A1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:95,626,727...95,639,808
Ensembl chr 1:95,613,558...95,640,131

G

coiled-coil domain containing 160

ClinVar Annotator: match by term: Partial hypoxanthine-guanine phosphoribosyltransferase deficiency

PMID:6087154 PMID:11018746 PMID:15571220 PMID:17027311 PMID:22157001 More...

NCBI chr X:132,468,141...132,478,616
Ensembl chr X:132,468,213...132,478,431

G

glypican 3

ClinVar Annotator: match by term: Partial hypoxanthine-guanine phosphoribosyltransferase deficiency

PMID:6087154 PMID:11018746 PMID:15571220 PMID:17027311 PMID:22157001 More...

NCBI chr X:131,868,986...132,236,824
Ensembl chr X:131,868,990...132,236,798

G

hypoxanthine phosphoribosyltransferase 1

ClinVar Annotator: match by term: HPRT1-Related Disorders | ClinVar Annotator: match by term: Partial hypoxanthine-guanine phosphoribosyltransferase deficiency
CTD Direct Evidence: marker/mechanism

OMIM
ClinVar
CTD

PMID:1301916 PMID:1483694 PMID:1487231 PMID:1551676 PMID:1618489 More...

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

microRNA 106a

ClinVar Annotator: match by term: Partial hypoxanthine-guanine phosphoribosyltransferase deficiency

PMID:6087154 PMID:11018746 PMID:15571220 PMID:17027311 PMID:22157001 More...

NCBI chr X:132,422,584...132,422,661
Ensembl chr X:132,422,584...132,422,661

G

microRNA 19b-2

ClinVar Annotator: match by term: Partial hypoxanthine-guanine phosphoribosyltransferase deficiency

PMID:6087154 PMID:11018746 PMID:15571220 PMID:17027311 PMID:22157001 More...

NCBI chr X:132,422,072...132,422,167
Ensembl chr X:132,422,072...132,422,167

G

PHD finger protein 6

ClinVar Annotator: match by term: Partial hypoxanthine-guanine phosphoribosyltransferase deficiency

PMID:6087154 PMID:11018746 PMID:15571220 PMID:17027311 PMID:22157001 More...

NCBI chr X:132,656,658...132,699,720
Ensembl chr X:132,656,672...132,699,127

Juvenile Pauciarticular Chronic Arthritis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RT1 class II, locus Db1

susceptibility

DNA:polymorphism: :HLA-DRB1*1104, HLA-DRB1*080(human)

RGD

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

juvenile rheumatoid arthritis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acid phosphatase 3

CTD Direct Evidence: marker/mechanism

NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:104,905,586...104,954,236

G

acrosin binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr 4:157,851,149...157,864,211
Ensembl chr 4:157,841,841...157,864,213

G

adenylate cyclase 7

CTD Direct Evidence: marker/mechanism

NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311

G

arachidonate 12-lipoxygenase, 12S type

CTD Direct Evidence: marker/mechanism

NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542

G

ankyrin repeat domain 9

CTD Direct Evidence: marker/mechanism

NCBI chr 6:130,001,914...130,008,792
Ensembl chr 6:129,998,486...130,008,923

G

aminopeptidase O

CTD Direct Evidence: marker/mechanism

NCBI chr17:1,811,281...2,127,316
Ensembl chr17:1,811,980...2,127,331

G

aquaporin 9

CTD Direct Evidence: marker/mechanism

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

G

amphiregulin

CTD Direct Evidence: marker/mechanism

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:95,786,130...96,093,111
Ensembl chr 7:95,787,818...96,092,754

G

AVL9 cell migration associated

CTD Direct Evidence: marker/mechanism

NCBI chr 4:85,961,493...86,008,347
Ensembl chr 4:85,961,635...86,008,791

G

beta-1,4-galactosyltransferase 5

CTD Direct Evidence: marker/mechanism

NCBI chr 3:156,018,056...156,033,983
Ensembl chr 3:156,018,053...156,070,074

G

BEN domain containing 2

CTD Direct Evidence: marker/mechanism

NCBI chr X:33,401,122...33,465,427

G

bridge-like lipid transfer protein family member 3B

CTD Direct Evidence: marker/mechanism

NCBI chr 7:24,181,635...24,261,720
Ensembl chr 7:24,181,644...24,261,720

G

BTG anti-proliferation factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

G

BTG anti-proliferation factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170

G

complement C8 beta chain

CTD Direct Evidence: marker/mechanism

NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565

G

similar to human chromosome 2 open reading frame 88

CTD Direct Evidence: marker/mechanism

NCBI chr 9:48,539,140...48,584,882
Ensembl chr 9:48,568,409...48,584,831

G

caldesmon 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932

G

calmodulin regulated spectrin-associated protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:8,746,176...8,806,067
Ensembl chr 3:8,746,176...8,806,072

G

coiled-coil domain containing 122

ClinVar Annotator: match by term: JUVENILE ARTHRITIS

NCBI chr15:52,407,717...52,470,163
Ensembl chr15:52,407,717...52,470,163

G

C-C motif chemokine receptor 5

no_association

DNA:frameshift mutation:cds:p.S185_T195del rs333 (human)
DNA:polymorphisms: :multiple (human)

RGD

PMID:17565662 PMID:16775617

RGD:1626283, RGD:1626284

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

G

CD14 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD83 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083

G

CD8 subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr 4:103,312,596...103,328,523
Ensembl chr 4:103,312,578...103,328,553

G

class II, major histocompatibility complex, transactivator

susceptibility
no_association

DNA:polymorphism:exon:1614G>C (human)
DNA:polymorphism:promoter:rs3087456, no association in a German cohort (Human)

RGD

PMID:17661914 PMID:16426246

RGD:5491187, RGD:5491189

NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440

G

clusterin

CTD Direct Evidence: marker/mechanism

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

CKLF-like MARVEL transmembrane domain containing 2B

CTD Direct Evidence: marker/mechanism

NCBI chr19:640,838...651,872
Ensembl chr19:640,824...651,939

G

cAMP responsive element modulator

CTD Direct Evidence: marker/mechanism

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

C-reactive protein

protein:increased expression:serum

RGD

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

cytotoxic T-lymphocyte-associated protein 4

CTD Direct Evidence: marker/mechanism

NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963

G

cortactin

CTD Direct Evidence: marker/mechanism

NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164

G

C-X-C motif chemokine ligand 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 3

CTD Direct Evidence: marker/mechanism

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425

G

C-X-C motif chemokine receptor 4

CTD Direct Evidence: marker/mechanism

PMID:19565504 PMID:26387944

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

death associated protein kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991

G

DNA-damage inducible transcript 3

CTD Direct Evidence: marker/mechanism

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dual specificity phosphatase 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499

G

dual specificity phosphatase 4

CTD Direct Evidence: marker/mechanism

NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138

G

dysferlin

CTD Direct Evidence: marker/mechanism

NCBI chr 4:116,490,877...116,690,709
Ensembl chr 4:116,490,616...116,690,709

G

epidermal growth factor

CTD Direct Evidence: marker/mechanism

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

early growth response 1

CTD Direct Evidence: marker/mechanism

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

E74 like ETS transcription factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:135,292,291...135,385,942
Ensembl chr 2:135,294,906...135,385,947

G

ethanolamine kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:176,126,056...176,170,325
Ensembl chr 4:176,126,180...176,193,770

G

ETS variant transcription factor 6

CTD Direct Evidence: marker/mechanism

NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992

G

FAM20A, golgi associated secretory pathway pseudokinase

CTD Direct Evidence: marker/mechanism

NCBI chr10:94,638,836...94,697,814
Ensembl chr10:94,642,850...94,697,672

G

fatty acid hydroxylase domain containing 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:42,245,808...42,271,679
Ensembl chr10:42,246,868...42,271,871

G

Fc gamma receptor 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994

G

FCH and double SH3 domains 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:155,444,471...155,685,350
Ensembl chr 1:155,444,460...155,685,539

G

Fos proto-oncogene, AP-1 transcription factor subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

FOS like 2, AP-1 transcription factor subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

G

forkhead box P1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258

G

growth arrest and DNA-damage-inducible, alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

guanosine monophosphate reductase

CTD Direct Evidence: marker/mechanism

NCBI chr17:19,151,820...19,189,626
Ensembl chr17:19,151,815...19,189,621

G

G protein subunit gamma 11

CTD Direct Evidence: marker/mechanism

NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442

G

glycoprotein Ib platelet subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr11:82,378,216...82,379,393
Ensembl chr11:82,378,199...82,379,392

G

glutathione S-transferase theta 1

susceptibility

DNA:deletion: :

RGD

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

H2B clustered histone 8

CTD Direct Evidence: marker/mechanism

NCBI chr17:42,708,658...42,709,408

G

heparin-binding EGF-like growth factor

CTD Direct Evidence: marker/mechanism

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

G

HERPUD family member 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:23,573,374...23,618,380
Ensembl chr 8:23,573,379...23,617,874

G

homeostatic iron regulator

DNA:missense mutation:cds:p.C282Y (human)

RGD

NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502

G

histone cluster 1 H2A family member F

CTD Direct Evidence: marker/mechanism

NCBI chr17:41,379,404...41,379,796
Ensembl chr17:41,379,404...41,379,796

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:83,273,176...83,274,317

G

heat shock protein family D (Hsp60) member 1

protein:increased expression:serum,synovial fluid:

RGD

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

insulin-like growth factor 1 receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

interleukin 1 alpha

DNA:SNP:promoter:-889C>T (human)

RGD

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 receptor antagonist

CTD Direct Evidence: marker/mechanism

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 2

protein:increased expression:mononuclear cell

RGD

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 6

protein:increased expression:serum:

RGD

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit alpha 2b

CTD Direct Evidence: marker/mechanism

NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168

G

integrin subunit beta 5

CTD Direct Evidence: marker/mechanism

NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472

G

jumonji domain containing 1C

CTD Direct Evidence: marker/mechanism

NCBI chr20:21,332,147...21,494,220
Ensembl chr20:21,332,147...21,463,122

G

Jun proto-oncogene, AP-1 transcription factor subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

lysine acetyltransferase 6B

CTD Direct Evidence: marker/mechanism

NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316

G

potassium inwardly-rectifying channel, subfamily J, member 15

CTD Direct Evidence: marker/mechanism

NCBI chr11:34,577,397...34,621,725
Ensembl chr11:34,577,363...34,621,952

G

KLF transcription factor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

KRAS proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:178,185,418...178,218,484

G

laccase domain containing 1

ClinVar Annotator: match by term: JUVENILE ARTHRITIS

PMID:25147203 PMID:25220867 PMID:25741868 PMID:27881174 PMID:29717096 More...

NCBI chr15:52,390,267...52,407,630
Ensembl chr15:52,395,183...52,407,545

G

leukocyte immunoglobulin like receptor A5

CTD Direct Evidence: marker/mechanism

NCBI chr 1:69,973,292...69,978,750
Ensembl chr 1:69,973,292...70,001,718

G

LIM domain containing preferred translocation partner in lipoma

CTD Direct Evidence: marker/mechanism

NCBI chr11:75,787,326...76,426,646
Ensembl chr11:75,797,078...76,422,597

G

mitotic arrest deficient 1 like 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703

G

MAF bZIP transcription factor F

CTD Direct Evidence: marker/mechanism

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

mastermind-like transcriptional coactivator 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:10,268,611...10,588,307
Ensembl chr 8:10,268,665...10,587,107

G

microtubule-associated protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mannose binding lectin 2

RGD

NCBI chr 1:228,016,439...228,024,736

G

mex-3 RNA binding family member C

CTD Direct Evidence: marker/mechanism

NCBI chr18:67,167,600...67,188,595
Ensembl chr18:67,166,718...67,188,595

G

membrane spanning 4-domains A4A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:208,060,507...208,085,121
Ensembl chr 1:208,046,971...208,085,119

G

moesin

CTD Direct Evidence: marker/mechanism

NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628

G

MTSS I-BAR domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:90,488,751...90,628,007
Ensembl chr 7:90,488,754...90,627,968

G

myocardial zonula adherens protein

CTD Direct Evidence: marker/mechanism

NCBI chr 8:72,155,817...72,243,036
Ensembl chr 8:72,131,530...72,243,036

G

nudE neurodevelopment protein 1-like 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:53,505,628...53,582,025
Ensembl chr10:53,516,491...53,570,907

G

nuclear receptor subfamily 4, group A, member 2

CTD Direct Evidence: marker/mechanism

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

nuclear receptor subfamily 4, group A, member 3

CTD Direct Evidence: marker/mechanism

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

neuregulin 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884

G

oxidized low density lipoprotein receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523

G

oncostatin M

CTD Direct Evidence: marker/mechanism

NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313

G

protein kinase C and casein kinase substrate in neurons 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:114,505,525...114,599,087
Ensembl chr 7:114,505,152...114,598,546

G

phosphate cytidylyltransferase 1B, choline

CTD Direct Evidence: marker/mechanism

NCBI chr X:58,378,090...58,471,623
Ensembl chr X:58,378,116...58,468,935

G

period circadian regulator 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431

G

phosphoglucomutase 5

CTD Direct Evidence: marker/mechanism

NCBI chr 1:222,325,638...222,513,434
Ensembl chr 1:222,325,643...222,513,437

G

plasminogen activator, urokinase receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595

G

polo-like kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947

G

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255

G

protein S

CTD Direct Evidence: marker/mechanism

NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286

G

protein tyrosine phosphatase, non-receptor type 22

DNA: snp : cds : rs2476601

RGD

NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779

G

R3H domain containing 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:63,212,519...63,340,574
Ensembl chr 7:63,232,346...63,340,540

G

RasGEF domain family, member 1B

CTD Direct Evidence: marker/mechanism

NCBI chr14:9,859,512...10,380,044
Ensembl chr14:9,860,247...10,379,741

G

RNA binding motif protein 47

CTD Direct Evidence: marker/mechanism

NCBI chr14:42,053,290...42,191,572
Ensembl chr14:42,154,142...42,189,431

G

arginine-glutamic acid dipeptide repeats

CTD Direct Evidence: marker/mechanism

NCBI chr 5:160,765,855...161,097,678
Ensembl chr 5:160,765,934...161,097,677

G

similar to RIKEN cDNA 3110043O21

CTD Direct Evidence: marker/mechanism

NCBI chr 5:49,766,340...49,791,434
Ensembl chr 5:49,766,325...49,791,408

G

Rho-related BTB domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:19,327,142...19,456,121
Ensembl chr20:19,327,155...19,403,012

G

ring finger protein 103

CTD Direct Evidence: marker/mechanism

NCBI chr 4:103,526,456...103,542,529
Ensembl chr 4:103,526,502...103,555,919

G

RT1 class II, locus Ba

DNA:polymorphism (human)

RGD

PMID:19811310 PMID:10457895

RGD:5147815, RGD:5147863

NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744

G

RT1 class II, locus Bb

DNA:polymorphism (human)

RGD

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

G

RT1 class II, locus Db1

DNA:polymorphism (human)

RGD

PMID:19908388 PMID:10457895

RGD:5147587, RGD:5147863

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

selectin P

severity

protein:increased expression:plasma

RGD

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

SH2 domain containing 2A

RGD

NCBI chr 2:173,312,253...173,318,810
Ensembl chr 2:173,312,253...173,318,810

G

SH3 domain binding glutamate-rich protein like 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:84,461,019...84,553,124
Ensembl chr 8:84,461,121...84,551,564

G

salt-inducible kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991

G

signal-induced proliferation-associated 1 like 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:101,839,351...102,118,408
Ensembl chr 6:101,839,404...102,116,950

G

solute carrier family 11 member 1

DNA:repeat:promoter (human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16597321 PMID:10857800

NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101

G

solute carrier family 22 member 16

CTD Direct Evidence: marker/mechanism

NCBI chr20:43,972,808...44,068,447
Ensembl chr20:43,972,836...44,065,019

G

solute carrier family 26 member 2

susceptibility

DNA:SNPs: :

RGD

NCBI chr18:54,648,276...54,666,627
Ensembl chr18:54,652,951...54,666,626

G

solute carrier family 2 member 3

CTD Direct Evidence: marker/mechanism

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

G

SMAD family member 3

CTD Direct Evidence: marker/mechanism

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

stabilin 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:6,330,435...6,360,934
Ensembl chr16:6,330,444...6,360,923

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

stromal interaction molecule 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363

G

transcription factor 7 like 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967

G

transcription factor Dp-1

CTD Direct Evidence: marker/mechanism

NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817

G

tissue factor pathway inhibitor

CTD Direct Evidence: marker/mechanism

NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880

G

thrombomodulin

protein:increased expression:serum

RGD

NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193

G

thrombospondin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

TNF alpha induced protein 6

CTD Direct Evidence: marker/mechanism

NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649

G

TNF alpha induced protein 8

CTD Direct Evidence: marker/mechanism

NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517

G

tumor necrosis factor receptor superfamily, member 22

CTD Direct Evidence: marker/mechanism

NCBI chr 1:198,840,452...198,860,713
Ensembl chr 1:198,840,453...198,856,309

G

TRAF2 and NCK interacting kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 2:111,184,352...111,587,993
Ensembl chr 2:111,184,387...111,580,750

G

triggering receptor expressed on myeloid cells-like 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:12,635,584...12,642,324
Ensembl chr 9:12,635,590...12,642,347

G

tubulin tyrosine ligase like 5

CTD Direct Evidence: marker/mechanism

NCBI chr 6:105,483,091...105,700,920
Ensembl chr 6:105,483,191...105,700,934

G

tubulin, beta 2A class IIa

CTD Direct Evidence: marker/mechanism

NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714

G

ubiquitin-conjugating enzyme E2E 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:7,439,751...7,493,410
Ensembl chr15:7,439,759...7,493,400

G

ubiquitin protein ligase E3C

CTD Direct Evidence: marker/mechanism

NCBI chr 4:5,648,932...5,749,922
Ensembl chr 4:5,648,690...5,750,011

G

WASP family member 3

CTD Direct Evidence: marker/mechanism

NCBI chr12:8,563,805...8,660,799
Ensembl chr12:8,562,062...8,660,751

G

WW domain-containing oxidoreductase

CTD Direct Evidence: marker/mechanism

NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391

G

zinc finger AN1-type containing 3

CTD Direct Evidence: marker/mechanism

NCBI chr20:8,083,407...8,279,617
Ensembl chr20:8,082,200...8,279,616

G

zinc finger, C3H1-type containing

CTD Direct Evidence: marker/mechanism

NCBI chr 7:51,008,251...51,064,666
Ensembl chr 7:51,007,984...51,064,661

Knee Osteoarthritis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

annexin A2

disease_progression

protein:increased expression:chondrocyte:

RGD

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

annexin A5

disease_progression

protein:increased expression:chondrocyte:

RGD

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

androgen receptor

DNA:repeat:exon:c.172(CAG)8-34 (human)

RGD

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

asporin

severity

mRNA:increased expression:cartilage:
DNA:repeats:exon:

RGD

PMID:15640800 PMID:15640800

RGD:9684965, RGD:9684965

NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,080,639...15,104,041

G

beta-2 microglobulin

protein:increased expression:serum

RGD

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

BCL2 associated X, apoptosis regulator

treatment

RGD

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

treatment

RGD

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone gamma-carboxyglutamate protein

RGD

PMID:22294259 PMID:21387139

RGD:6483563, RGD:6483595

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

C-C motif chemokine receptor 2

mRNA,protein:increased expression:dorsal root ganglion:

RGD

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

CD36 molecule

disease_progression

RGD

PMID:21765106 PMID:19342682

RGD:6893494, RGD:6893565

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

catenin beta 1

protein:increased expression:cartilage:

RGD

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome P450, family 19, subfamily a, polypeptide 1

DNA:SNP:intron, 5' utr: (rs1062033) (human)

RGD

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

discoidin domain receptor tyrosine kinase 2

ameliorates

RGD

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

diacylglycerol O-acyltransferase 2

severity

mRNA,protein:increased expression:fat pad:

RGD

NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428

G

dickkopf WNT signaling pathway inhibitor 1

RGD

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

eukaryotic translation elongation factor 1 alpha 1

RGD

NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839

G

EGF containing fibulin extracellular matrix protein 1

protein:increased expression:serum:

RGD

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018

G

endothelial PAS domain protein 1

no_association

DNA:SNP:5' utr: (rs17039192) (human)

RGD

PMID:22247019 PMID:20495570

RGD:10395367, RGD:10395368

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

erythropoietin

treatment

RGD

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

estrogen receptor 1

DNA:repeat:promoter:-1174(TA)9-25 (human)
DNA:polymorphisms, haplotype:intron, exon
DNA:SNP:cds:c.1782G>A (rs2228480) (human)
DNA:SNPs:intron: (rs2234693, rs9340799) (human)

RGD

PMID:16098017 PMID:15380041 PMID:20128071 PMID:24772413

RGD:10043199, RGD:10045840, RGD:10045835, RGD:10045829

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

DNA:repeat:intron:c.1092+3607(CA)13-27 (human)

RGD

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

coagulation factor II, thrombin

RGD

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

fibroblast growth factor receptor 3

treatment

RGD

NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341

G

growth differentiation factor 5

CTD Direct Evidence: marker/mechanism

NCBI chr 3:144,454,316...144,458,508
Ensembl chr 3:144,454,338...144,458,612

G

glutathione-disulfide reductase

protein:increased expression:synovial fluid

RGD

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

high mobility group box 1

severity

protein:increased expression:synovial fluid
mRNA:decreased expression:articular cartilage

RGD

PMID:21968272 PMID:19139395

RGD:10402061, RGD:10402184

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

high mobility group box 2

severity

mRNA:decreased expression:articular cartilage

RGD

PMID:19139395 PMID:19139395

RGD:10402184, RGD:10402184

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140

G

heat shock protein 90 alpha family class A member 1

mRNA:increased expression:tibial plateaux (mouse)
mRNA:decreased expression:blood (human)

RGD

PMID:9497939 PMID:16139532

RGD:10412655, RGD:10429075

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

insulin-like growth factor 1

disease_progression
severity

protein:decreased expression:plasma (rat)
mRNA:increased expression:meniscus:

RGD

PMID:8461919 PMID:17133593 PMID:9497937 PMID:20633672

RGD:10045862, RGD:10003130, RGD:10046057, RGD:10045868

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

RGD

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

interleukin 1 alpha

protein:increased expression:cartilage cell:

RGD

PMID:24534736 PMID:9497937 PMID:9034998

RGD:10045944, RGD:10046057, RGD:10045946

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 2

severity

protein:increased expression:synovial fluid:

RGD

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

susceptibility

DNA:repeat:intron: (rs8179190) (human)

RGD

PMID:18182309 PMID:24406619

RGD:2317291, RGD:10402787

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

Klotho

susceptibility

DNA:SNPs:promoter,exon:395G>A,2998C>T(human)

RGD

NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080

G

leptin

protein:decreased expression:serum:

RGD

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

leptin receptor

susceptibility

protein:increased expression:serum:
DNA:SNP:cds:668A>G(human)

RGD

PMID:23575542 PMID:23575542

RGD:10411887, RGD:10411887

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

lysophosphatidic acid receptor 1

susceptibility

DNA:snp:promoter:g.-2820G>A (rs10980705) (human)

RGD

NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895

G

latent transforming growth factor beta binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:20,029,629...20,425,339
Ensembl chr 6:20,029,629...20,425,349

G

microRNA 219a-1

CTD Direct Evidence: therapeutic

NCBI chr20:4,829,687...4,829,796
Ensembl chr20:4,829,687...4,829,796

G

microRNA 223

RNA:increased expression:synovial membrane

RGD

NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996

G

matrix metallopeptidase 1

treatment

RGD

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 13

ameliorates

RGD

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 3

treatment

RGD

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

proenkephalin

treatment

RGD

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129

G

prostaglandin E synthase

RGD

NCBI chr 3:14,177,892...14,189,236

G

strawberry notch homolog 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:32,175,176...32,234,200
Ensembl chr12:32,185,485...32,230,158

G

solute carrier family 26 member 2

susceptibility

DNA:deletion:promoter:-716_-713del4A(human)

RGD

NCBI chr18:54,648,276...54,666,627
Ensembl chr18:54,652,951...54,666,626

G

transforming growth factor alpha

protein:increased expression:cartilage

RGD

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

vitamin D receptor

GAD

NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677

G

WW domain containing E3 ubiquitin protein ligase 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:35,346,826...35,471,251
Ensembl chr19:35,346,814...35,472,699

osteoarthritis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA acyltransferase 2

CTD Direct Evidence: marker/mechanism

NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249

G

aggrecan

treatment

RGD

PMID:22833446 PMID:21853458

RGD:11570535, RGD:11570544

NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627

G

aconitase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

actin, beta

CTD Direct Evidence: marker/mechanism

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

ADAM metallopeptidase domain 12

susceptibility

RGD

NCBI chr 1:188,686,984...189,014,206
Ensembl chr 1:188,686,989...189,020,667

G

ADAM metallopeptidase domain 15

RGD

NCBI chr 2:174,754,629...174,765,136
Ensembl chr 2:174,754,633...174,765,113

G

ADAM metallopeptidase with thrombospondin type 1 motif, 14

DNA:missense mutation:cds: (rs4747096) (human)

RGD

NCBI chr20:29,143,029...29,219,846
Ensembl chr20:29,144,354...29,219,866

G

ADAM metallopeptidase with thrombospondin type 1 motif, 4

treatment

associated with Bone Diseases, Metabolic

RGD

NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065

G

ADAM metallopeptidase with thrombospondin type 1 motif, 5

treatment
disease_progression
no_association

associated with Bone Diseases, Metabolic
mRNA:increased expression:cartilage
protein:alternative form:synovium
DNA:missense mutations:exon: (rs226794, rs2830585) (human)
DNA:missense mutation:exon:p.R614H (human)

RGD

PMID:23982761 PMID:22432033 PMID:17530714 PMID:22084394 PMID:23954517 More...

RGD:10043101, RGD:10043110, RGD:2300093, RGD:10003165, RGD:10043107, RGD:10043106, RGD:10043105, RGD:10043103, RGD:10043102

NCBI chr11:25,000,627...25,047,205
Ensembl chr11:25,000,637...25,047,205

G

adhesion G protein-coupled receptor G2

CTD Direct Evidence: marker/mechanism

NCBI chr X:34,297,402...34,422,590
Ensembl chr X:34,297,402...34,422,609

G

advanced glycosylation end product-specific receptor

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16948116 PMID:23894457

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

adenylate kinase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618

G

aldo-keto reductase family 1, member C1

CTD Direct Evidence: marker/mechanism

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1, member C2

CTD Direct Evidence: marker/mechanism

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

aldehyde dehydrogenase 1 family, member A2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107

G

asporin

no_association

DNA:repeats:exon:
CTD Direct Evidence: marker/mechanism

NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,080,639...15,104,041

G

ATPase Na+/K+ transporting subunit alpha 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918

G

ATPase H+ transporting V1 subunit B2

CTD Direct Evidence: marker/mechanism

NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745

G

ATPase copper transporting alpha

OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:612400

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

BCL2-associated agonist of cell death

RGD

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAG cochaperone 6

susceptibility

DNA:SNP: :rs3117582(human)

RGD

NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657

G

BCL2 associated X, apoptosis regulator

protein:increased expression:chondrocyte

RGD

PMID:19217321 PMID:16864079

RGD:10053643, RGD:10054095

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

protein:increased expression:chondrocyte

RGD

PMID:19217321 PMID:16864079

RGD:10053643, RGD:10054095

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

beclin 1

protein:decreased expression:cartilage

RGD

PMID:20187128 PMID:20187128

RGD:6483317, RGD:6483317

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

bone gamma-carboxyglutamate protein

disease_progression

RGD

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

bone morphogenetic protein 2

susceptibility

RGD

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

bone morphogenetic protein 4

CTD Direct Evidence: marker/mechanism

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

bone morphogenetic protein 6

CTD Direct Evidence: marker/mechanism

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

bone morphogenetic protein 7

OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401

NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788

G

bone morphogenetic protein receptor type 1A

OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401

NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616

G

calcitonin-related polypeptide alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

caspase 3

treatment

RGD

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

treatment

RGD

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

caveolin 1

RGD

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

C-C motif chemokine ligand 22

protein:increased expression:plasma:

RGD

NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400

G

C-C motif chemokine receptor 4

protein:increased expression:synovial membrane:

RGD

NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056

G

CD36 molecule

susceptibility

RGD

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

cyclin-dependent kinase inhibitor 2A

treatment

RGD

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

CCAAT/enhancer binding protein beta

susceptibility

RGD

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

chitinase 3 like 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787

G

cartilage intermediate layer protein

disease_progression

RGD

NCBI chr 8:65,777,281...65,792,251
Ensembl chr 8:65,777,281...65,792,251

G

C-type lectin domain family 3, member B

disease_progression

RGD

NCBI chr 8:122,810,120...122,815,837
Ensembl chr 8:122,810,149...122,815,835

G

chloride intracellular channel 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712

G

chloride intracellular channel 4

CTD Direct Evidence: marker/mechanism

NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452

G

clusterin

CTD Direct Evidence: marker/mechanism

PMID:17568789 PMID:18784066

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

collagen type XI alpha 1 chain

OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401

NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853

G

collagen type I alpha 1 chain

no_association

DNA:SNP:intron:IVS1

RGD

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

CTD Direct Evidence: marker/mechanism

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type II alpha 1 chain

onset
treatment

DNA:missense mutation:exon:p.R75C (human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:9061443 PMID:16189708 PMID:16755660 PMID:19216861

RGD:8657384, RGD:8661226

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

collagen type VI alpha 2 chain

CTD Direct Evidence: marker/mechanism

NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564

G

collagen type IX alpha 1 chain

OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401

NCBI chr 9:26,585,034...26,668,222
Ensembl chr 9:26,585,034...26,668,213

G

cartilage oligomeric matrix protein

CTD Direct Evidence: marker/mechanism

NCBI chr16:19,047,206...19,055,584
Ensembl chr16:19,047,207...19,055,845

G

cathepsin D

CTD Direct Evidence: marker/mechanism

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin K

CTD Direct Evidence: marker/mechanism

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

C-X-C motif chemokine ligand 2

CTD Direct Evidence: marker/mechanism

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 6

CTD Direct Evidence: marker/mechanism

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

dual adaptor of phosphotyrosine and 3-phosphoinositides 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:226,425,890...226,475,445
Ensembl chr 2:226,425,898...226,475,423

G

discoidin domain receptor tyrosine kinase 2

disease_progression

RGD

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

DEAD-box helicase 3, X-linked

CTD Direct Evidence: marker/mechanism

NCBI chr X:9,479,532...9,493,169
Ensembl chr X:9,479,532...9,493,168

G

dipeptidase 1

CTD Direct Evidence: marker/mechanism

NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257

G

dihydropyrimidinase-like 2

CTD Direct Evidence: marker/mechanism

NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829

G

EGF like repeats and discoidin domains 3

CTD Direct Evidence: marker/mechanism

NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008