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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:influenza
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Accession:DOID:8469 term browser browse the term
Definition:A viral infectious disease that results in infection, located in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness. (DO)
Synonyms:exact_synonym: Grippe;   Influenza with other manifestations;   flu;   influenza with non-respiratory manifestation
 xref: EFO:0007328;   ICD10CM:J11.1;   ICD9CM:487;   NCI:C53482
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
influenza term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 ISO associated with Asthma;protein:decreased expression:alveolar system (mouse) RGD PMID:12707338 RGD:4145439 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd274 CD274 molecule ISO RGD PMID:24187568 RGD:41410793 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd8a CD8 subunit alpha ISO protein:altered expression:lung, T cell (mouse) RGD PMID:28355204 RGD:124715455 NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B ISO RGD PMID:20081832 RGD:155641261 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cftr CF transmembrane conductance regulator treatment ISO RGD PMID:23749967 RGD:35673331 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Clk1 CDC-like kinase 1 ISO RGD PMID:34883209 RGD:155641258 NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000 		JBrowse link
G Cr2 complement C3d receptor 2 exacerbates ISO RGD PMID:19388171 RGD:127338248 NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235 		JBrowse link
G Il33 interleukin 33 ISO RGD PMID:28401938 RGD:40400699 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Mavs mitochondrial antiviral signaling protein treatment ISO RGD PMID:31461653 RGD:40902992 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094 		JBrowse link
G Mir21 microRNA 21 ameliorates ISO associated with asthma; RGD PMID:27448447 RGD:41404696 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Nrg1 neuregulin 1 ISO neurotropic influenza A in Tap1-/- strain;mRNA (type III):decreased expression:prefrontal cortex (mouse) RGD PMID:19362585 RGD:39456087 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO mRNA:increased expression:lung RGD PMID:31782850 RGD:39131288 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Rnasel ribonuclease L ISO RGD PMID:23913960 RGD:40902622 NCBI chr13:65,894,990...65,910,354
Ensembl chr13:65,901,459...65,908,704 		JBrowse link
G Son SON DNA and RNA binding protein ISO RGD PMID:34883209 RGD:155641258 NCBI chr11:30,850,890...30,923,167
Ensembl chr11:30,892,005...30,923,167 		JBrowse link
avian influenza term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 severity
treatment		 ISO human protein in a mouse model RGD PMID:24800825 PMID:24800825 RGD:32716391, RGD:32716391 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Mx1 MX dynamin like GTPase 1 susceptibility ISO CTD Direct Evidence: therapeutic
human gene in a mouse model		 CTD
RGD		 PMID:178595 PMID:28396461 RGD:126777675 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:18613795 RGD:5135502 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 ameliorates ISO RGD PMID:28423682 RGD:127229942 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
Human Influenza term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase susceptibility ISO DNA:polymorphism:cds:allele AB (human) RGD PMID:6189297 PMID:4375858 RGD:5128836, RGD:39938844 NCBI chr 3:10,162,087...10,182,835
Ensembl chr 3:10,162,096...10,191,423 		JBrowse link
G Atf3 activating transcription factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G C3 complement C3 ISO RGD PMID:21408070 RGD:5129492 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Casp1 caspase 1 ISO RGD PMID:19362023 RGD:5130181 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Cat catalase ISO RGD PMID:16804020 PMID:19959187 PMID:20653246 RGD:5130864, RGD:5130744, RGD:5130201 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 ISO associated with Asthma;protein:increased expression:respiratory system fluid/secretion RGD PMID:20656925 PMID:12707338 RGD:4145452, RGD:4145439 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO mRNA:increased expression:lung
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:23326326 PMID:20967263 RGD:4891425 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl28 C-C motif chemokine ligand 28 resistance ISO RGD PMID:19847203 RGD:4892196 NCBI chr 2:51,601,354...51,625,999
Ensembl chr 2:51,601,331...51,625,997 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 susceptibility ISO protein:increased expression:lung (mouse) RGD PMID:20656925 PMID:16208318 RGD:4145452, RGD:4892131 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 severity ISO DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) RGD PMID:19039768 PMID:20875295 PMID:18617426 RGD:4892119, RGD:4892063, RGD:4892122 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd14 CD14 molecule ISO RGD PMID:17825924 RGD:4144809 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd209c CD209c molecule susceptibility ISO RGD PMID:21191006 RGD:5131189 NCBI chr12:1,936,233...1,943,841
Ensembl chr12:1,936,396...1,942,040 		JBrowse link
G Cd209d CD209d molecule susceptibility ISO RGD PMID:21191006 RGD:5131189 NCBI chr12:1,891,109...1,897,559
Ensembl chr12:1,891,113...1,901,171 		JBrowse link
G Cd28 Cd28 molecule ISO RGD PMID:21389258 RGD:5131611 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cd40 CD40 molecule ISO RGD PMID:19922665 RGD:5132270 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd80 Cd80 molecule ISO RGD PMID:19922665 PMID:10604996 RGD:5132270, RGD:5132623 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd86 CD86 molecule ISO protein:increased expression:mediastinal lymph node, B cell (mouse) RGD PMID:19933871 RGD:4892570 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Crp C-reactive protein ISO protein:increased expression:serum RGD PMID:21509252 RGD:5131277 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Csf2 colony stimulating factor 2 ISO RGD PMID:20427198 PMID:21474645 RGD:5131472, RGD:5131470 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 ISO protein:increased expression:respiratory system fluid/secretion
protein:increased expression:lung, serum		 RGD PMID:20656925 PMID:17348295 RGD:4145452, RGD:4145366 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 ISO mRNA:increased expression:lung RGD PMID:21251691 PMID:20967263 RGD:5135026, RGD:4891425 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Ddx60 DEXD/H-box helicase 60 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr16:28,077,000...28,197,903
Ensembl chr16:28,076,999...28,179,526 		JBrowse link
G Egr1 early growth response 1 ISO mRNA:increased expression:frontal cortex (mouse) RGD PMID:21289196 RGD:5131660 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971 		JBrowse link
G Foxp2 forkhead box P2 ISO RGD PMID:18248790 RGD:11536002 NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683 		JBrowse link
G Gbp1 guanylate binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131 		JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744 		JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294 		JBrowse link
G Ifi35 interferon-induced protein 35 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952 		JBrowse link
G Ifi44 interferon-induced protein 44 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844 		JBrowse link
G Ifi44l interferon-induced protein 44-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359 		JBrowse link
G Ifih1 interferon induced with helicase C domain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456 		JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307 		JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 susceptibility ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Influenza, severe, susceptibility to		 CTD
OMIM
ClinVar		 PMID:20943977 PMID:22446628 PMID:23326326 NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203 		JBrowse link
G Il10 interleukin 10 susceptibility ISO RGD PMID:20200252 RGD:4140426 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B ISO RGD PMID:16389596 RGD:4145426 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:serum RGD PMID:20003352 RGD:4888530 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il15 interleukin 15 ISO mRNA, protein:increased expression:lung RGD PMID:20212069 PMID:21098221 PMID:19234203 RGD:4996471, RGD:4994196, RGD:4996472 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il15ra interleukin 15 receptor subunit alpha ISO RGD PMID:21098221 RGD:4994196 NCBI chr17:66,802,300...66,831,973
Ensembl chr17:66,802,334...66,832,278 		JBrowse link
G Il17a interleukin 17A ISO mRNA, protein:increased expression:lung RGD PMID:19783685 PMID:19265125 RGD:4889102, RGD:4889150 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il17ra interleukin 17 receptor A ISO RGD PMID:19783685 RGD:4889102 NCBI chr 4:153,667,534...153,690,174
Ensembl chr 4:153,667,534...153,690,174 		JBrowse link
G Il18 interleukin 18 ISO RGD PMID:15606801 RGD:4889964 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha ISO protein:increased expression:lung RGD PMID:11535264 RGD:4142860 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:20438620 RGD:4142822 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist disease_progression ISO protein:increased expression:serum RGD PMID:9439800 PMID:20840779 RGD:4143228, RGD:4143203 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2 interleukin 2 ISO protein:increased expression:serum RGD PMID:21603856 RGD:5147905 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il22 interleukin 22 ISO RGD PMID:21178015 PMID:20504940 RGD:5147404, RGD:5147405 NCBI chr 7:53,801,206...53,805,673
Ensembl chr 7:53,801,206...53,806,186 		JBrowse link
G Il4 interleukin 4 ISO RGD PMID:21092162 RGD:5128546 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 ISO RGD PMID:20731583 RGD:4143268 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irf7 interferon regulatory factor 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Lamp3 lysosomal-associated membrane protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr11:81,153,491...81,224,643
Ensembl chr11:81,193,649...81,221,784 		JBrowse link
G Ly6e lymphocyte antigen 6 family member E ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689 		JBrowse link
G Lyst lysosomal trafficking regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:26597256 NCBI chr17:86,241,384...86,443,501
Ensembl chr17:86,241,384...86,443,480 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased activity:lung, heart, brain RGD PMID:20299740 RGD:5130855 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mx1 MX dynamin like GTPase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507 		JBrowse link
G Mx2 MX dynamin like GTPase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342 		JBrowse link
G Nos1 nitric oxide synthase 1 ISO protein:increased expression:hippocampus RGD PMID:9552178 RGD:5132870 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO mRNA:increased expression:olfactory epithelium
mRNA,protein:increased expression:brain		 RGD PMID:17674769 PMID:17030871 PMID:18080188 RGD:4891919, RGD:4891952, RGD:4891937 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517 		JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371 		JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781 		JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641 		JBrowse link
G Parp12 poly (ADP-ribose) polymerase family, member 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 4:67,826,548...67,885,356
Ensembl chr 4:67,839,237...67,883,685 		JBrowse link
G Plscr1 phospholipid scramblase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692 		JBrowse link
G Prf1 perforin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26597256 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:16272346 RGD:5143925 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rig1 RNA sensor RIG-1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 ISO RGD PMID:19386707 RGD:4144816 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 ISO RGD PMID:21087648 RGD:5144131 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Rtp4 receptor (chemosensory) transporter protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr11:77,237,341...77,249,194
Ensembl chr11:77,238,216...77,335,437 		JBrowse link
G Samd9 sterile alpha motif domain containing 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 4:31,164,639...31,184,278
Ensembl chr 4:31,164,510...31,184,322 		JBrowse link
G Serping1 serpin family G member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
G Sftpd surfactant protein D IMP RGD PMID:16787926 RGD:4143518 NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927 		JBrowse link
G Siglec1 sialic acid binding Ig like lectin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 3:118,287,988...118,307,125
Ensembl chr 3:118,287,988...118,306,850 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23129053 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tdrd7 tudor domain containing 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 5:60,238,742...60,312,548
Ensembl chr 5:60,238,678...60,312,544 		JBrowse link
G Tlr2 toll-like receptor 2 ISO protein:increased expression:monocyte RGD PMID:18657324 RGD:4145339 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr3 toll-like receptor 3 ISO mRNA:increased expression:lung (mouse) RGD PMID:16789835 PMID:18654661 RGD:5129219, RGD:5129136 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tmprss11d transmembrane serine protease 11D ISO CTD Direct Evidence: marker/mechanism CTD PMID:20237084 PMID:23072892 NCBI chr14:21,707,336...21,769,398
Ensembl chr14:21,707,336...21,769,396 		JBrowse link
G Tmprss4 transmembrane serine protease 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26889029 NCBI chr 8:45,475,819...45,508,409
Ensembl chr 8:45,476,053...45,508,409 		JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:serum RGD PMID:21062445 RGD:5128683 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO protein:increased expression:serum (human) RGD PMID:17182684 PMID:19497758 RGD:5131157, RGD:5131432 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfsf10 TNF superfamily member 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tor1b torsin family 1, member B ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 3:14,243,181...14,249,279
Ensembl chr 3:14,243,243...14,249,272 		JBrowse link
G Trex1 three prime repair exonuclease 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
G Ube2l6 ubiquitin-conjugating enzyme E2L 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr 3:69,873,025...69,888,042
Ensembl chr 3:69,873,424...69,888,048 		JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:33639165 NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393 		JBrowse link
G Xaf1 XIAP associated factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr10:56,917,378...56,929,791
Ensembl chr10:56,917,121...56,929,770 		JBrowse link
G Xist X inactive specific transcript ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr  X:68,474,987...68,492,500 JBrowse link
G Zcchc2 zinc finger CCHC-type containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326326 NCBI chr13:22,118,677...22,193,626
Ensembl chr13:22,119,568...22,166,373 		JBrowse link
influenza A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase exacerbates ISO RGD PMID:31509427 RGD:126779564 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Btk Bruton tyrosine kinase ameliorates ISO Associated with Acute Lung Injury RGD PMID:29516781 RGD:124713566 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853 		JBrowse link
G Duox1 dual oxidase 1 ISO protein:decreased expression:blood plasma (human) RGD PMID:24888898 RGD:40903071 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563 		JBrowse link
G Duox2 dual oxidase 2 severity ISO RGD PMID:28936773 PMID:25751630 PMID:29556357 RGD:40924644, RGD:40925925, RGD:40925921 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902 		JBrowse link
G Ifih1 interferon induced with helicase C domain 1 ISO mRNA:increased expression:nasal cavity mucosa (mouse) RGD PMID:25751630 RGD:40925925 NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456 		JBrowse link
G Il21 interleukin 21 ISO RGD PMID:25251568 RGD:127285548 NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Il27 interleukin 27 ISO protein:increased expression:blood serum (human) RGD PMID:22343630 RGD:126790513 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 exacerbates ISO RGD PMID:26241898 RGD:11055126 NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ameliorates ISO RGD PMID:22514650 RGD:150340681 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Marco macrophage receptor with collagenous structure ameliorates ISO RGD PMID:21562316 RGD:41412197 NCBI chr13:31,616,278...31,648,521
Ensembl chr13:31,616,278...31,648,521 		JBrowse link
G Mavs mitochondrial antiviral signaling protein disease_progression ISO RGD PMID:27438481 RGD:40903047 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094 		JBrowse link
G Mir146a microRNA 146a exacerbates
ameliorates		 ISO RGD PMID:31638222 PMID:30611999 RGD:126925152, RGD:126925153 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mx1 MX dynamin like GTPase 1 ameliorates ISO fused with PTD 9-arginine sequence
human gene in a mouse model		 RGD PMID:30696001 PMID:31653718 PMID:1371172 PMID:30945621 RGD:126777671, RGD:126777680, RGD:126777676, RGD:126777673 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507 		JBrowse link
G Plac8 placenta associated 8 ISO RGD PMID:32639988 RGD:40925929 NCBI chr14:9,052,601...9,074,264
Ensembl chr14:9,063,048...9,074,264 		JBrowse link
G Ppia peptidylprolyl isomerase A ameliorates ISO human gene in a mouse model RGD PMID:27354005 RGD:150429624 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
G Rig1 RNA sensor RIG-1 ISO mRNA:increased expression:nasal cavity mucosa (mouse) RGD PMID:25751630 RGD:40925925 NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 exacerbates
susceptibility		 ISO RGD PMID:27321907 PMID:32200799 PMID:28410401 RGD:127229911, RGD:127229922, RGD:127229918 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Stat2 signal transducer and activator of transcription 2 exacerbates ISO RGD PMID:30337919 RGD:41789626 NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967 		JBrowse link
swine influenza term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase disease_progression
treatment		 ISO RGD PMID:23028320 PMID:22281510 RGD:32716383, RGD:32716408 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 disease_progression ISO RGD PMID:23785507 PMID:24799604 RGD:39939079, RGD:39939082 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Irf5 interferon regulatory factor 5 disease_progression ISO RGD PMID:29046356 RGD:40924628 NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267 		JBrowse link
G Klrk1 killer cell lectin like receptor K1 ISO RGD PMID:20130050 RGD:40818269 NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459 		JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 severity ISO RGD PMID:23602571 PMID:20130050 RGD:40818268, RGD:40818269 NCBI chr 1:69,614,744...69,622,594
Ensembl chr 1:69,616,601...69,660,558 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma severity ISO DNA:misense mutation, substitution:cds:S1635Y, D2850D (rs17847825, rs2230460 ) (human) RGD PMID:29867955 PMID:27468760 PMID:29867955 RGD:38599181, RGD:38599196, RGD:38599181 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 severity ISO RGD PMID:24453980 RGD:126925972 NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203 		JBrowse link
G Tslp thymic stromal lymphopoietin treatment ISO RGD PMID:32060507 RGD:38549590 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19099
    disease of anatomical entity 18440
      respiratory system disease 5241
        influenza 132
          Human Influenza + 111
          avian influenza 4
          swine influenza 8
Path 2
Term Annotations click to browse term
  disease 19099
    disease by infectious agent 2253
      viral infectious disease 1716
        RNA Virus Infections 1397
          Orthomyxoviridae Infections 135
            influenza 132
              Human Influenza + 111
              avian influenza 4
              swine influenza 8
paths to the root