RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: peptic ulcer disease
Accession: DOID:750
browse the term
Definition: Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Synonyms: exact_synonym: Gastroduodenal Ulcer; Marginal Ulcer; Marginal Ulcers; acute peptic ulcer with hemorrhage; acute peptic ulcer with hemorrhage and perforation; acute peptic ulcer without hemorrhage and without perforation; gastroduodenal ulcers; peptic ulcer; peptic ulcers
related_synonym: PHOSPHOLIPASE A2, GROUP IV A, DEFICIENCY OF
primary_id: MESH:D010437
xref: ICD10CM:K27 ; ICD9CM:533 ; MONDO:0004247 ; NCI:C3318
For additional species annotation, visit the
Alliance of Genome Resources .
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Cnr1
cannabinoid receptor 1
IDA
RGD
PMID:19827302
RGD:2314640
NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
treatment susceptibility
ISO
DNA:polymorphisms:exons: DNA:SNP: :CYP2C19*17(human)
RGD
PMID:9867757 PMID:23267857
RGD:124713408 , RGD:124713412
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Edn1
endothelin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16384872
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Gast
gastrin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10700044
NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
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Gsr
glutathione-disulfide reductase
treatment
IEP
RGD
PMID:24480520
RGD:10401900
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Hmox1
heme oxygenase 1
IMP
RGD
PMID:20610858
RGD:4145283
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hpgd
15-hydroxyprostaglandin dehydrogenase
treatment
IEP
RGD
PMID:23884819
RGD:11667098
NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
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Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19448967
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il27
interleukin 27
ISO
associated with Helicobacter infections;protein:increased expression:blood serum (human)
RGD
PMID:21791025
RGD:126790506
NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
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Il33
interleukin 33
susceptibility
ISO
associated with Helicobacter Infections;DNA:SNP: : rs1929992(human)
RGD
PMID:31491552
RGD:39938849
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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RT1-Db1
RT1 class II, locus Db1
susceptibility
ISO
associated with Helicobacter Infections;DNA:polymorphisms:cds:HLA-DRB1*07, HLA-DRB1*17 (human)
RGD
PMID:20405713
RGD:5147609
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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Abo
ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22387998
NCBI chr 3:10,162,087...10,182,835
Ensembl chr 3:10,162,096...10,191,423
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Aco1
aconitase 1
IDA
protein:increased activity:duodenal mucosa
RGD
PMID:19342511
RGD:11541091
NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
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Cftr
CF transmembrane conductance regulator
IDA
RGD
PMID:15905414
RGD:1599596
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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Egr1
early growth response 1
ISO
RGD
PMID:24385009
RGD:8694318
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Il27
interleukin 27
ISO
associated with Helicobacter Infections;protein:increased expression:blood serum (human)
RGD
PMID:31702083
RGD:126790551
NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
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Nos2
nitric oxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12481160 PMID:17045617
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Pla2g4a
phospholipase A2 group 4A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18451993
NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
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Psca
prostate stem cell antigen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22387998
NCBI chr 7:106,598,203...106,603,114
Ensembl chr 7:106,595,284...106,609,746
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12481160
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Slc11a2
solute carrier family 11 member 2
IEP
mRNA, protein:increased expression:duodenal mucosa
RGD
PMID:19342511
RGD:11541091
NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
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Stat3
signal transducer and activator of transcription 3
IMP
RGD
PMID:24385009
RGD:8694318
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tfrc
transferrin receptor
IEP
protein:increased expression:duodenal mucosa
RGD
PMID:19342511
RGD:11541091
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Tgfb1
transforming growth factor, beta 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12868675
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Vegfa
vascular endothelial growth factor A
IEP
associated with Candidiasis;protein:decreased expression:Duodenum:
RGD
PMID:18622701
RGD:7483560
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Ada
adenosine deaminase
ISO
protein:decreased activity:stomach:
RGD
PMID:20029210
RGD:152998951
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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Adm
adrenomedullin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:9845272
NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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Agt
angiotensinogen
treatment
IDA
RGD
PMID:24231511
RGD:11039418
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Angpt1
angiopoietin 1
IEP
protein:increased expression:stomach
RGD
PMID:12768384
RGD:1601496
NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
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Angpt2
angiopoietin 2
IEP
protein:increased expression:stomach (rat)
RGD
PMID:12768384
RGD:1601496
NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
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Bad
BCL2-associated agonist of cell death
treatment
IDA
RGD
PMID:24378970
RGD:10053695
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bcl2
BCL2, apoptosis regulator
treatment
IDA
RGD
PMID:24378970
RGD:10053695
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
treatment
IDA
RGD
PMID:24378970
RGD:10053695
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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Casp3
caspase 3
treatment
IEP
RGD
PMID:29339218
RGD:13792597
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
IEP ISO
protein:increased expression:stomach CTD Direct Evidence: therapeutic
CTD RGD
PMID:1887894 PMID:17895592
RGD:5130860
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cblif
cobalamin binding intrinsic factor
ISO
associated with Polycythemia; mRNA:decreased expression:gastric mucosa:
RGD
PMID:26485402
RGD:11049581
NCBI chr 1:208,605,983...208,620,231
Ensembl chr 1:208,605,983...208,620,344
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Cck
cholecystokinin
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:9872509 PMID:10422768 PMID:10458643 PMID:11025360 PMID:11787760 PMID:15024038 More...
NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
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Cftr
CF transmembrane conductance regulator
treatment
IDA
RGD
PMID:23596793
RGD:11567229
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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Col18a1
collagen type XVIII alpha 1 chain
IEP
Protein:decreased expression:serum
RGD
PMID:11353854
RGD:1600910
NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
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Egf
epidermal growth factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:9324159 PMID:9479624
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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Epo
erythropoietin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20723003
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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F13a1
coagulation factor XIII A1 chain
IEP
RGD
PMID:11435721
RGD:708325
NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700
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Fas
Fas cell surface death receptor
treatment
IEP
RGD
PMID:29339218
RGD:13792597
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
treatment
IEP
RGD
PMID:29339218
RGD:13792597
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Fgf2
fibroblast growth factor 2
treatment
ISO
RGD
PMID:9127818
RGD:8655642
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
treatment
IEP IMP
RGD
PMID:37637418 PMID:24496494
RGD:405650590 , RGD:405650591
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Foxo4
forkhead box O4
IEP
mRNA,protein:increased expression:gastric mucosa:
RGD
PMID:22735908
RGD:10402364
NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115
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Ghrl
ghrelin and obestatin prepropeptide
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:15177919 PMID:16259727
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
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Hrh3
histamine receptor H3
IDA
RGD
PMID:15680274
RGD:1626428
NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642
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Iapp
islet amyloid polypeptide
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:9286623
NCBI chr 4:175,237,107...175,244,373
Ensembl chr 4:175,237,115...175,242,920
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Idua
alpha-L-iduronidase
IEP
RGD
PMID:3713687
RGD:12910841
NCBI chr14:1,031,588...1,059,494
Ensembl chr14:1,032,171...1,046,522
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Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11376495
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il23a
interleukin 23 subunit alpha
treatment
ISO
RGD
PMID:23874957
RGD:39458037
NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
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Il25
interleukin 25
treatment
IEP
RGD
PMID:26054198
RGD:40902976
NCBI chr15:28,408,766...28,412,157
Ensembl chr15:28,408,842...28,411,893
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Lep
leptin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:10422768 PMID:11025360 PMID:11787760 PMID:15024038 PMID:16015682 PMID:18181030 More...
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Mapk1
mitogen activated protein kinase 1
IDA
RGD
PMID:25518106
RGD:13800896
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
IDA
RGD
PMID:25518106
RGD:13800896
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mmp13
matrix metallopeptidase 13
IEP
mRNA:increased expression:stomach
RGD
PMID:15375341
RGD:10043177
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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Mmp2
matrix metallopeptidase 2
IEP
mRNA:increased expression:stomach
RGD
PMID:15375341
RGD:10043177
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp3
matrix metallopeptidase 3
IEP
mRNA:increased expression:stomach
RGD
PMID:15375341
RGD:10043177
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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Mmp9
matrix metallopeptidase 9
IEP ISO
protein:increased expression:stomach secretion CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:17603938 PMID:17603938
RGD:1642033
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
treatment
IEP IDA
mRNA, protein:decreased expression:stomach
RGD
PMID:11956390 PMID:16240224
RGD:2324968 , RGD:7364759
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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Muc6
mucin 6, oligomeric mucus/gel-forming
treatment
IDA
RGD
PMID:16240224
RGD:7364759
NCBI chr 1:196,726,678...196,764,842
Ensembl chr 1:196,726,807...196,764,842
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Nos2
nitric oxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12481160 PMID:15138204 PMID:19066340
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nos3
nitric oxide synthase 3
treatment
ISO IEP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:19066340 PMID:29095895
RGD:13446410
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Nrg1
neuregulin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16357062
NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
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Oxt
oxytocin/neurophysin I prepropeptide
IDA
RGD
PMID:11764003
RGD:2304192
NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
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Oxtr
oxytocin receptor
IMP
RGD
PMID:11764003
RGD:2304192
NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674
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Ptger1
prostaglandin E receptor 1
treatment
IMP ISO
RGD
PMID:10807413 PMID:10807413
RGD:10043357 , RGD:10043357
NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559
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Ptgs1
prostaglandin-endoperoxide synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10594344 PMID:19066340
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Ptgs2
prostaglandin-endoperoxide synthase 2
IMP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:9024292 PMID:10594344 PMID:11376495 PMID:12481160 PMID:19066340 PMID:17673547 PMID:17673547 More...
RGD:2300260 , RGD:2300260
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Sst
somatostatin
IEP
RGD
PMID:17990461
RGD:2303186
NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
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Tek
TEK receptor tyrosine kinase
IEP
protein:increased expression:stomach
RGD
PMID:12768384
RGD:1601496
NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
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Tff1
trefoil factor 1
IEP
mRNA, protein:increased expression:stomach mucosa
RGD
PMID:11350545
RGD:2292012
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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Timp1
TIMP metallopeptidase inhibitor 1
IEP
mRNA:increased expression:stomach
RGD
PMID:15375341
RGD:10043177
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15138204
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Vegfa
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11353854
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Vgf
VGF nerve growth factor inducible
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20805684
NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
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Bmp4
bone morphogenetic protein 4
IEP
protein:increased expression:esophagus:
RGD
PMID:17570215
RGD:8699511
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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Ccl5
C-C motif chemokine ligand 5
IEP
associated with Asthma;mRNA:increased expression:esophagus
RGD
PMID:18222984
RGD:2307110
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Cldn3
claudin 3
IEP
protein:altered expression:epithelial cell, esophagus:
RGD
PMID:21373849
RGD:11344880
NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
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Cldn4
claudin 4
IEP
protein:altered localization:esophagus epithelium, cytoplasm
RGD
PMID:16143882
RGD:2317602
NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
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Egfr
epidermal growth factor receptor
IEP
mRNA, protein:increased expression:esophagus, basal cell
RGD
PMID:11966524
RGD:10395244
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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F11r
F11 receptor
treatment
IEP
RGD
PMID:19478094
RGD:7488941
NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
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Il13
interleukin 13
IEP
associated with asthma; mRNA, protein:increased expression:esophagus, Bronchoalveolar Lavage Fluid
RGD
PMID:18222984
RGD:2307110
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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Il5
interleukin 5
IEP
associated with asthma; mRNA:increased expression:esophagus
RGD
PMID:18222984
RGD:2307110
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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Mir223
microRNA 223
IEP
RNA:increased expression: esophagus
RGD
PMID:28757556
RGD:25824949
NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996
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Mir29a
microRNA 29a
IEP
RGD
PMID:28757556
RGD:25824949
NCBI chr 4:59,650,608...59,650,695
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Psmb9
proteasome 20S subunit beta 9
IEP
protein:decreased expression:esophageal epithelium (rat)
RGD
PMID:23942904
RGD:9854630
NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
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Ptges
prostaglandin E synthase
IEP
protein:increased expression:esophagus
RGD
PMID:16210398
RGD:2300085
NCBI chr 3:14,177,892...14,189,236
G
Tjp1
tight junction protein 1
IEP
RGD
PMID:19653339
RGD:2325133
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
G
Tnf
tumor necrosis factor
IDA
RGD
PMID:15942680
RGD:1580209
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Vdr
vitamin D receptor
susceptibility
ISO
DNA:SNPs,haplotype:exon:rs1989969,rs2238135 (human)
RGD
PMID:25910066
RGD:11055189
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
G
Alb
albumin
ISO
protein:decreased expression:serum
RGD
PMID:908508
RGD:2325683
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
G
Egf
epidermal growth factor
ISO
protein:increased expression:saliva
RGD
PMID:10811321
RGD:2317668
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
G
Igf1r
insulin-like growth factor 1 receptor
ISO
mRNA and protein: increased expression::poor prognosis for high expression
RGD
PMID:15867218
RGD:7242847
NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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