Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:pulmonary hypertension
go back to main search page
Accession:DOID:6432 term browser browse the term
Definition:A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries. (DO)
Synonyms:exact_synonym: PHT
 narrow_synonym: PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED;   primary pulmonary hypertension, fenfluramine-associated
 primary_id: MESH:D006976
 xref: EFO:0001361;   ICD10CM:I27.20;   NCI:C3120
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
pulmonary hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca3 ATP binding cassette subfamily A member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26780485 NCBI chr10:13,886,948...13,944,286
Ensembl chr10:13,887,083...13,944,285 		JBrowse link
G Ace angiotensin I converting enzyme ISO CTD Direct Evidence: marker/mechanism CTD PMID:12359135 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Ace2 angiotensin converting enzyme 2 treatment ISO CTD Direct Evidence: therapeutic
human protein in a rat model 		CTD
RGD		 PMID:31931441 PMID:25225206 RGD:40818280 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596 		JBrowse link
G Acvrl1 activin A receptor like type 1 susceptibility
disease_progression 		ISO
IEP 		associated with hereditary haemorrhagic telangiectasia;DNA:missense mutations
CTD Direct Evidence: marker/mechanism
DNA:mutations (human)
mRNA:increased expression:lung 		CTD
RGD		 PMID:26540443 PMID:14684682 PMID:20056902 PMID:17392319 RGD:1601117, RGD:5128837, RGD:1601116 NCBI chr 7:134,117,917...134,135,306
Ensembl chr 7:134,118,024...134,135,305 		JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide ISO RGD PMID:20431245 RGD:5128886 NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:229,648,501...229,665,232 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO RGD PMID:19168697 RGD:5686821 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Adm adrenomedullin ISO RGD PMID:14718403 RGD:1625305 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371 		JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO protein:increased expression:lung (human) RGD PMID:21041689 RGD:7244258 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685 		JBrowse link
G Agt angiotensinogen IDA RGD PMID:21381494 RGD:5129162 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a onset ISO DNA:polymorphism:3' utr:1166A>C (human) RGD PMID:19332265 RGD:5147450 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660 		JBrowse link
G Ahr aryl hydrocarbon receptor ameliorates IMP 6-formylindolo[3,2-b]carbazole (FICZ)|semaxanib (CHEBI:91083)
compared to wild type littermates 		RGD PMID:33836606 PMID:33836606 RGD:401940192, RGD:401940192 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Ahrem1Iexas aryl hydrocarbon receptor; CRISPR/Cas9 induced mutant1, Iexas ameliorates IMP compared to wild type littermates RGD PMID:33836606 RGD:401940192
G Alas1 5'-aminolevulinate synthase 1 IEP mRNA:increased expression:lung (rat) RGD PMID:16181105 RGD:4144185 NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase treatment ISO
IEP
IMP
IDA 		protein:increased expression:artery
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:14726295 PMID:9445303 PMID:31462075 PMID:31462075 PMID:14726295 More... RGD:1626154, RGD:14975304, RGD:14975304, RGD:4890418, RGD:734558 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein ISO
IMP 		protein:increased expression:artery RGD PMID:9445303 PMID:8647941 RGD:1626154, RGD:734558 NCBI chr12:10,785,254...10,809,295
Ensembl chr12:10,785,257...10,817,038 		JBrowse link
G Angpt1 angiopoietin 1 IEP protein:decreased expression:pulmonary artery RGD PMID:18073453 RGD:2316069 NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696 		JBrowse link
G Angpt2 angiopoietin 2 IEP protein:increased expression:pulmonary artery (rat) RGD PMID:19712575 RGD:2314185 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:77,790,563...77,841,239 		JBrowse link
G Apln apelin ISO protein:decreased expression:plasma RGD PMID:16263185 RGD:1626175 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:132,081,759...132,091,246 		JBrowse link
G Arg2 arginase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24951775 NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:103,668,988...103,694,375 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 treatment IEP
ISO 		RGD PMID:27144451 PMID:23804254 RGD:13782086, RGD:13782089 NCBI chr12:39,733,519...39,782,942
Ensembl chr12:39,733,458...39,782,934 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha treatment IDA chronic thromboembolic pulmonary hypertension RGD PMID:21396162 RGD:13703061 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922 		JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 treatment IEP
IMP 		mRNA, protein:increased expression:lung, plasma (rat) RGD PMID:27916219 PMID:27491388 RGD:13800892, RGD:13800894 NCBI chr11:37,368,045...37,375,721
Ensembl chr11:37,368,042...37,375,466 		JBrowse link
G Atp7a ATPase copper transporting alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:24614111 NCBI chr  X:75,159,635...75,267,094
Ensembl chr  X:75,159,782...75,267,093 		JBrowse link
G Bcl2 BCL2, apoptosis regulator IEP protein:decreased expression:heart right ventricle RGD PMID:18441466 RGD:2293022 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 treatment IDA RGD PMID:22559233 RGD:10400914 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bdkrb2 bradykinin receptor B2 IDA RGD PMID:15878794 RGD:4890453 NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:130,237,255...130,267,209 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 IMP
IEP 		protein:increased expression:pulmonary artery RGD PMID:15931388 PMID:15931388 RGD:2293135, RGD:2293135 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A ISO RGD PMID:19324947 RGD:5129472 NCBI chr16:9,740,751...9,786,861
Ensembl chr16:9,742,875...9,786,861 		JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B ISO RGD PMID:19324947 RGD:5129472 NCBI chr 2:233,211,525...233,544,344
Ensembl chr 2:233,211,525...233,544,311 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 treatment
disease_progression 		ISO
IMP
IEP 		DNA:mutations: :multiple (human)
ClinVar Annotator: match by term: Pulmonary hypertension
induced by human ad-ALOX5
protein:decreased expression:lung
CTD Direct Evidence: marker/mechanism
DNA:missense mutations (human) 		ClinVar
CTD
RGD		 PMID:11590841 PMID:11893684 PMID:12358323 PMID:16297860 PMID:20496075 More... RGD:5129238, RGD:14975304, RGD:38500243, RGD:38500244, RGD:5129472, RGD:5129239, RGD:5129237, RGD:5129474, RGD:1580076 NCBI chr 9:68,685,942...68,801,353
Ensembl chr 9:68,685,988...68,801,350 		JBrowse link
G Bmpr2em1Sage bone morphogenetic protein receptor type 2; ZFN induced mutant 1, Sage IMP induced by human ad-ALOX5 RGD PMID:31462075 RGD:14975304
G Bmpr2em2Sage bone morphogenetic protein receptor type 2; ZFN induced mutant 2, Sage IMP induced by human ad-ALOX5 RGD PMID:31462075 RGD:14975304
G Brd4 bromodomain containing 4 ISO CTD Direct Evidence: therapeutic CTD PMID:26224795 NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,866,997...11,946,923 		JBrowse link
G Ca9 carbonic anhydrase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20110409 NCBI chr 5:62,559,024...62,565,626
Ensembl chr 5:62,558,823...62,565,626 		JBrowse link
G Calca calcitonin-related polypeptide alpha ISO CTD Direct Evidence: therapeutic CTD PMID:1357980 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529 		JBrowse link
G Casr calcium-sensing receptor IEP protein:increased expression:pulmonary artery (rat) RGD PMID:22730443 RGD:7205669 NCBI chr11:77,738,398...77,813,639
Ensembl chr11:77,740,614...77,810,167 		JBrowse link
G Cav1 caveolin 1 treatment ISO
IEP 		idiopathic pulmonary arterial hypertension (IPAH) RGD PMID:17470567 PMID:23538027 PMID:15353500 RGD:1625360, RGD:8662276, RGD:1581153 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740 		JBrowse link
G Cavin1 caveolae associated protein 1 ISS OMIM:615371 MouseDO NCBI chr10:86,384,401...86,398,240
Ensembl chr10:86,384,401...86,396,383 		JBrowse link
G Cbln2 cerebellin 2 precursor ISO CTD Direct Evidence: marker/mechanism CTD PMID:23502781 NCBI chr18:79,940,412...79,948,766
Ensembl chr18:82,215,220...82,222,648 		JBrowse link
G Ccl1 C-C motif chemokine ligand 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22507635 NCBI chr10:67,625,962...67,628,740
Ensembl chr10:67,625,962...67,628,790 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP
ISO 		protein:increased expression:lung, plasma
CTD Direct Evidence: marker/mechanism
protein:increased expression:bronchoalveolar lavage fluid (rat) 		CTD
RGD		 PMID:15302794 PMID:30418988 PMID:19087668 PMID:9605182 RGD:2307003, RGD:8549547 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased secretion:serum (human) RGD PMID:19932032 RGD:4891440 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Ccn2 cellular communication network factor 2 IEP protein:increased expression:pulmonary artery (rat) RGD PMID:19234054 RGD:2314535 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Cd209c CD209c molecule ISO RGD PMID:17107989 RGD:5131187 NCBI chr12:1,936,233...1,943,841
Ensembl chr12:6,733,287...6,741,808 		JBrowse link
G Cd209d CD209d molecule ISO RGD PMID:17107989 RGD:5131187 NCBI chr12:6,689,002...6,695,452
Ensembl chr12:6,689,002...6,698,976 		JBrowse link
G Cd28 Cd28 molecule ISO RGD PMID:19075187 RGD:5131619 NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:69,545,326...69,689,192 		JBrowse link
G Cd40 CD40 molecule treatment IMP RGD PMID:25998782 RGD:11344970 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cd40lg CD40 ligand IEP
ISO 		protein:increased expression:serum (rat)
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:15302794 PMID:25998782 RGD:11344970 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:140,164,302...140,176,475 		JBrowse link
G Cd86 CD86 molecule ISO protein:decreased expression:blood, myeloid dendritic cell (human) RGD PMID:19693657 RGD:4892293 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361 		JBrowse link
G Cdh5 cadherin 5 IEP protein:decreased expression:lung RGD PMID:25593290 RGD:38500244 NCBI chr19:821,875...860,931
Ensembl chr19:822,464...860,822 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A treatment ISO
IEP 		RGD PMID:24334871 PMID:24412385 RGD:10043360, RGD:10043361 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B treatment IEP RGD PMID:22383500 RGD:10045357 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Clu clusterin IEP RGD PMID:25069740 RGD:9068424 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Col1a1 collagen type I alpha 1 chain treatment IEP RGD PMID:25867313 RGD:11041577 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain treatment IEP RGD PMID:25867313 RGD:11041577 NCBI chr16:84,885,597...84,996,482
Ensembl chr16:84,885,597...84,996,482 		JBrowse link
G Crp C-reactive protein ISO associated with Pulmonary Disease, Chronic Obstructive RGD PMID:22333502 RGD:6482312 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514 		JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:17186992 PMID:12524378 RGD:11039432, RGD:11039539 NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860 		JBrowse link
G Ctnnd1 catenin delta 1 treatment IEP RGD PMID:25593290 RGD:38500244 NCBI chr 3:90,090,025...90,141,247
Ensembl chr 3:90,090,564...90,141,189 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO
IEP 		protein:increased expression:lung
associated with Heart Defects, Congenital
mRNA, protein:increased expression:lung 		RGD PMID:19948918 PMID:20869263 PMID:18630689 RGD:4891887, RGD:4891883, RGD:4891889 NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IEP
ISO 		mRNA, protein:increased expression:lung
associated with Scleroderma, Systemic;DNA:polymorphisms: :p.V249I, p.T280M (human) 		RGD PMID:17182651 PMID:16584113 RGD:4891893, RGD:4891896 NCBI chr 8:128,661,294...128,679,048
Ensembl chr 8:128,654,833...128,685,983 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 treatment IMP RGD PMID:21294880 RGD:6480473 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Cyba cytochrome b-245 alpha chain IDA
ISO 		associated with Anoxia;mRNA, protein:increased expression:lung RGD PMID:18424632 PMID:18952568 RGD:4773907, RGD:4762683 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214 		JBrowse link
G Cybb cytochrome b-245 beta chain treatment ISO
IEP 		associated with Anoxia RGD PMID:18952568 PMID:18424632 RGD:4762683, RGD:4773907 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP mRNA,protein:increased expression:lung RGD PMID:28956952 RGD:13702097 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 ISO RGD PMID:20118222 RGD:7243137 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042 		JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 IMP associated with Anoxia RGD PMID:12910720 RGD:4848274 NCBI chr  X:75,734,281...75,762,873
Ensembl chr  X:75,734,270...75,763,050 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 ISO RGD PMID:34739767 RGD:155646132 NCBI chr 3:126,770,945...126,780,769
Ensembl chr 3:126,770,794...126,780,763 		JBrowse link
G Dohh deoxyhypusine hydroxylase IEP protein:increased expression:pulmonary artery,right ventricle RGD PMID:38261723 RGD:597621636 NCBI chr 7:8,972,202...8,977,025
Ensembl chr 7:8,972,202...8,977,025 		JBrowse link
G Ece1 endothelin converting enzyme 1 IMP associated with Anoxia; RGD PMID:18767389 RGD:7243939 NCBI chr 5:155,361,031...155,462,723
Ensembl chr 5:155,360,639...155,462,719 		JBrowse link
G Edn1 endothelin 1 ISO
IEP 		associated with Pulmonary Disease, Chronic Obstructive; protein:increased secretion:plasma (human)
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:lung (rat)
Hypertension, Portopulmonary; protein:increased secretion:plasma (human)
Hypertension, Heritable Pulmonary Artery; mRNA:increased expression:bone marrow, macrophage (mouse) 		CTD
RGD		 PMID:7549228 PMID:9918753 PMID:12391278 PMID:20929026 PMID:20967148 More... RGD:4144865, RGD:4144128, RGD:4144882, RGD:4144877 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Edn2 endothelin 2 ISO RGD PMID:10598486 RGD:1580918 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:139,036,492...139,043,070 		JBrowse link
G Ednra endothelin receptor type A IMP
IDA
ISO 		RGD PMID:20531217 PMID:15243299 PMID:20562228 PMID:18506008 RGD:4892283, RGD:1580949, RGD:4144877, RGD:4892320 NCBI chr19:47,137,360...47,207,961
Ensembl chr19:47,137,771...47,201,284 		JBrowse link
G Ednrb endothelin receptor type B IMP
ISO
IDA 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:15927975 PMID:18091567 PMID:15243299 PMID:20562228 RGD:4892289, RGD:1580949, RGD:4144877 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765 		JBrowse link
G Egfr epidermal growth factor receptor ISO protein:increased expression:lung, arteriole (human) RGD PMID:12896876 PMID:21492463 RGD:5131639, RGD:5131626 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Egr1 early growth response 1 ISO
IEP 		protein:increased expression:lung (human)
mRNA, protein:increased expression:lung (rat)
mRNA, protein:increased expression:lung (mouse) 		RGD PMID:20889906 PMID:21924231 PMID:20889906 PMID:20023177 PMID:18599502 RGD:5131875, RGD:10395308, RGD:5131875, RGD:5131883, RGD:5131890 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24292273 NCBI chr 3:125,810,207...125,895,574
Ensembl chr 3:125,810,060...125,895,574 		JBrowse link
G Eif5a eukaryotic translation initiation factor 5A IEP protein:increased expression:pulmonary artery,right ventricle RGD PMID:38261723 RGD:597621636 NCBI chr10:55,138,821...55,143,272
Ensembl chr10:55,138,823...55,143,330 		JBrowse link
G Eng endoglin ISO RGD PMID:20042709 RGD:11041178 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:36,326,202...36,370,933 		JBrowse link
G Epas1 endothelial PAS domain protein 1 IEP
ISO 		DNA:missense mutation:cds: 2097G>A,p.G537R(human) RGD PMID:16215633 PMID:18650473 RGD:10395375, RGD:11041573 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729 		JBrowse link
G Ephx2 epoxide hydrolase 2 IMP RGD PMID:19226702 RGD:5688731 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:22559233 RGD:10400914 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725 		JBrowse link
G Esr1 estrogen receptor 1 ISO RGD PMID:20081107 RGD:4892253 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esr2 estrogen receptor 2 IDA RGD PMID:21700911 RGD:5508791 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G F5 coagulation factor V ISO Chronic thromboembolic pulmonary hypertension (CTEPH) RGD PMID:20182352 RGD:4892669 NCBI chr13:76,513,509...76,583,106
Ensembl chr13:79,046,448...79,116,247 		JBrowse link
G Fbln5 fibulin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12189163 NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:126,664,100...126,746,296 		JBrowse link
G Fgf2 fibroblast growth factor 2 IMP
ISO 		mRNA:increased expression:lung RGD PMID:19197140 PMID:19197140 RGD:2315911, RGD:2315911 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 IMP RGD PMID:19197140 RGD:2315911 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:73,194,631...73,249,855 		JBrowse link
G Foxo1 forkhead box O1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27663689 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419 		JBrowse link
G Gata4 GATA binding protein 4 IEP protein:increased expression:heart right ventricle RGD PMID:21059997 RGD:7207053 NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609 		JBrowse link
G Gata6 GATA binding protein 6 IEP
ISO 		mRNA, protein:decreased expression:lung
protein:decreased expression:lung, arteriole, venule (human) 		RGD PMID:19842842 PMID:23583651 PMID:23583651 RGD:2314194, RGD:13208869, RGD:13208869 NCBI chr18:2,460,909...2,492,322
Ensembl chr18:2,458,253...2,492,322 		JBrowse link
G Gba1 glucosylceramidase beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12359135 NCBI chr 2:176,902,141...176,916,015
Ensembl chr 2:176,907,154...176,916,985 		JBrowse link
G Gdf2 growth differentiation factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26801773 NCBI chr16:9,255,430...9,261,429
Ensembl chr16:9,261,662...9,267,677 		JBrowse link
G Gja1 gap junction protein, alpha 1 treatment IEP mRNA:increased expression:pulmonary artery RGD PMID:21414209 PMID:23321332 RGD:7207411, RGD:8662411 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Gpr182 G protein-coupled receptor 182 IEP mRNA:increased expression:lung RGD PMID:12622928 RGD:1625768 NCBI chr 7:63,585,997...63,589,088
Ensembl chr 7:65,452,965...65,474,998 		JBrowse link
G Has1 hyaluronan synthase 1 IEP RGD PMID:19915162 RGD:9588633 NCBI chr 1:67,366,460...67,378,686
Ensembl chr 1:67,366,460...67,378,444 		JBrowse link
G Has2 hyaluronan synthase 2 IEP mRNA:increased expression:lung RGD PMID:19915162 RGD:9588633 NCBI chr 7:90,002,929...90,028,933
Ensembl chr 7:90,002,929...90,018,535 		JBrowse link
G Has3 hyaluronan synthase 3 IEP mRNA:decreased expression:lung RGD PMID:19915162 RGD:9588633 NCBI chr19:34,768,421...34,782,170 JBrowse link
G Hdac1 histone deacetylase 1 ISO
IEP 		protein:increased expression:lung: RGD PMID:22711276 PMID:22711276 RGD:9590133, RGD:9590133 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387 		JBrowse link
G Hdac2 histone deacetylase 2 ISO protein:decreased expression:lung: RGD PMID:22711276 RGD:9590133 NCBI chr20:42,101,815...42,126,486
Ensembl chr20:42,102,861...42,126,311 		JBrowse link
G Hdac3 histone deacetylase 3 ISO protein:decreased expression:lung: RGD PMID:22711276 RGD:9590133 NCBI chr18:30,021,847...30,041,061
Ensembl chr18:30,021,941...30,041,025 		JBrowse link
G Hdac4 histone deacetylase 4 ISO protein:increased expression:lung: RGD PMID:22711276 RGD:9590133 NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:99,955,116...100,197,637 		JBrowse link
G Hdac5 histone deacetylase 5 ISO
IEP 		protein:increased expression:lung: RGD PMID:22711276 PMID:22711276 RGD:9590133, RGD:9590133 NCBI chr10:87,653,139...87,688,078
Ensembl chr10:87,652,656...87,694,244 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 ISO mRNA:decreased expression:lung: RGD PMID:34739767 RGD:155646132 NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:95,002,943...95,007,624 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP
ISO 		associated with Anoxia;protein:increased expression:pulmonary artery
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:20110409 PMID:17213961 PMID:16215633 RGD:1601553, RGD:10395375 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha IEP RGD PMID:16215633 RGD:10395375 NCBI chr 1:86,846,196...86,878,527
Ensembl chr 1:86,850,554...86,877,838 		JBrowse link
G Hk1 hexokinase 1 IEP mRNA:increased expression:lung RGD PMID:25767292 RGD:11353880 NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,773,220...30,874,814 		JBrowse link
G Hmgb1 high mobility group box 1 treatment IMP RGD PMID:25032709 RGD:10402082 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase IMP RGD PMID:12750068 RGD:5508701 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmox1 heme oxygenase 1 IEP
ISO
IDA 		RGD PMID:14970910 PMID:20957739 PMID:19409105 RGD:1582715, RGD:4145325, RGD:4145307 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hp haptoglobin treatment ISO protein:decreased expression:serum RGD PMID:2043024 PMID:25656991 PMID:19023114 PMID:19703762 RGD:1626353, RGD:11041794, RGD:5147440, RGD:5147420 NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase ISO mRNA, protein:increased expression:lung RGD PMID:24657469 RGD:11667099 NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ameliorates ISO RGD PMID:28473438 RGD:329955562 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:91,052,432...91,418,583 		JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B ISO CTD Direct Evidence: marker/mechanism CTD PMID:14659797 NCBI chr 9:94,184,442...94,206,851
Ensembl chr 9:94,190,109...94,204,087 		JBrowse link
G Hyal1 hyaluronidase 1 IEP mRNA:decreased expression:lung RGD PMID:19915162 RGD:9588633 NCBI chr 8:117,129,311...117,133,162
Ensembl chr 8:117,129,277...117,133,146 		JBrowse link
G Hyal2 hyaluronidase 2 IEP mRNA:decreased expression:lung RGD PMID:19915162 RGD:9588633 NCBI chr 8:117,121,802...117,125,494
Ensembl chr 8:117,121,787...117,125,493 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO associated with Heart Defects, Congenital; protein:increased secretion:serum (human) RGD PMID:21034646 RGD:4145436 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Id1 inhibitor of DNA binding 1 IDA RGD PMID:20522807 RGD:9686087 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685 		JBrowse link
G Ifngr1 interferon gamma receptor 1 ISO mRNA: increased expression RGD PMID:20808962 RGD:4892610 NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:16,152,879...16,171,437 		JBrowse link
G Il10 interleukin 10 disease_progression ISO protein:increased expression:serum RGD PMID:20713898 RGD:4142530 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il13 interleukin 13 ISO associated with sclerosis; protein:increased expression:plasma (human)
associated with Scleroderma, Limited;protein:increased expression:plasma 		RGD PMID:19799786 PMID:21425123 RGD:4145600, RGD:8549528 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 ISO RGD PMID:20671265 PMID:20808962 RGD:4892611, RGD:4892610 NCBI chr  X:120,213,670...120,294,777
Ensembl chr  X:120,214,075...120,274,461 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 ISO mRNA:increased expression:lung RGD PMID:20522789 RGD:4892612 NCBI chr  X:115,814,620...115,886,080
Ensembl chr  X:115,814,622...115,841,455 		JBrowse link
G Il18 interleukin 18 ISO RGD PMID:17400729 RGD:4889590 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:serum
associated with Scleroderma, Limited;protein:increased expression:serum 		RGD PMID:20713898 PMID:20808962 RGD:4142530, RGD:4892610 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO RGD PMID:7946395 RGD:4143197 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il23r interleukin 23 receptor ISO associated with Scleroderma, Systemic;DNA:SNPs: :rs11209026, rs11465804 (human) RGD PMID:19918037 RGD:5096624 NCBI chr 4:97,910,230...98,003,759
Ensembl chr 4:97,909,972...98,004,110 		JBrowse link
G Il4 interleukin 4 ISO RGD PMID:20889544 RGD:5128515 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 disease_progression
ameliorates 		ISO
IMP
IDA 		RGD PMID:20713898 PMID:38602915 PMID:20693255 RGD:4142530, RGD:407450417, RGD:4143246 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Il6em1Yona interleukin 6; CRISPR/Cas9 induced mutant 1, Yona ameliorates IMP RGD PMID:38602915 RGD:407450417
G Kcna5 potassium voltage-gated channel subfamily A member 5 ISO
IDA 		DNA:SNPs:promoter, cds
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:27522126 PMID:17267549 PMID:20303989 PMID:17596340 RGD:1627654, RGD:7242752, RGD:1627651 NCBI chr 4:161,040,853...161,044,311
Ensembl chr 4:160,996,950...161,044,408 		JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 severity ISO
IMP 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:30365877 PMID:31347976 RGD:151347452 NCBI chr 6:31,483,129...31,519,061
Ensembl chr 6:31,483,140...31,519,061 		JBrowse link
G Kcnk3em1Ang potassium two pore domain channel subfamily K member 3; CRISPR/Cas9 induced mutant1, Ang severity IMP RGD PMID:31347976 RGD:151347452
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28090300 NCBI chr15:351,065...1,057,117
Ensembl chr15:351,659...1,057,117 		JBrowse link
G Kdm5b lysine demethylase 5B ISO associated with Hypoxia;protein:increased expression:pulmonary artery,smooth muscle tissue (mouse) RGD PMID:30172777 RGD:329955443 NCBI chr13:48,554,367...48,625,721
Ensembl chr13:48,554,420...48,626,423 		JBrowse link
G Lcn2 lipocalin 2 IEP
ISO 		mRNA,protein:increased expression:lung
associated with congenital heart disease; protein:increased expression:plasma 		RGD PMID:25076856 PMID:25076856 RGD:126781744, RGD:126781744 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Lepr leptin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:30689673 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Lox lysyl oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24614111 NCBI chr18:48,162,889...48,175,640
Ensembl chr18:48,165,688...48,239,810 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment ISO RGD PMID:25907942 RGD:13800893 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment ISO RGD PMID:25907942 RGD:13800893 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mb myoglobin disease_progression IEP RGD PMID:23142560 RGD:460967415 NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:110,640,512...110,647,958 		JBrowse link
G Mfn1 mitofusin 1 IEP protein:decreased expression:heart right ventricle (rat) RGD PMID:27422986 RGD:12910832 NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190 		JBrowse link
G Mif macrophage migration inhibitory factor ISO associated with sclerodema, systemic; protein:increased expression:serum RGD PMID:18618071 RGD:4891006 NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121 		JBrowse link
G Mir125a microRNA 125a treatment IDA RGD PMID:29700287 RGD:26884455 NCBI chr 1:67,350,675...67,350,759
Ensembl chr 1:67,350,675...67,350,759 		JBrowse link
G Mir145 microRNA 145 IEP mRNA:decreased expression:pulmonary artery (rat) RGD PMID:35369850 RGD:155230820 NCBI chr18:55,099,640...55,099,727 JBrowse link
G Mir204 microRNA 204 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26224795 NCBI chr 1:229,743,461...229,743,570
Ensembl chr 1:229,743,461...229,743,570 		JBrowse link
G Mir21 microRNA 21 IEP RNA:increased expression:lung RGD PMID:32402408 RGD:41410883 NCBI chr10:71,902,600...71,902,691 JBrowse link
G Mir223 microRNA 223 treatment IEP
IDA
ISO 		Chronic Intermittent Hypoxia
RNA:decreased expression:lung, pulmonary aorta, pulmonary aorta smooth muscle 		RGD PMID:30246291 PMID:30507047 PMID:26084306 PMID:26084306 RGD:25823198, RGD:25824849, RGD:25824847, RGD:25824847 NCBI chr  X:65,151,383...65,151,492
Ensembl chr  X:65,151,383...65,151,492 		JBrowse link
G Mmp1 matrix metallopeptidase 1 IDA RGD PMID:23087098 RGD:7207217 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964 		JBrowse link
G Mmp9 matrix metallopeptidase 9 severity ISO
IDA
IEP 		associated with Pulmonary Embolism;protein:increased expression:lung, plasma
associated with Heart Failure, Congestive;protein:decreased expression:monocyte 		RGD PMID:21063214 PMID:23087098 PMID:18355767 PMID:17133179 PMID:16867026 RGD:5129210, RGD:7207217, RGD:5130155, RGD:1642053, RGD:1642028 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:23470622 RGD:10041039 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor treatment IDA RGD PMID:22306243 RGD:7240564 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase susceptibility ISO
IEP 		mRNA,protein:increased expression:lung,pulmonary arterial endothelial cell:
protein:increased expression:lung: 		RGD PMID:28202489 PMID:28202489 PMID:28202489 RGD:13781882, RGD:13781882, RGD:13781882 NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:55,151,926...55,189,544 		JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 IMP
ISO 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:27522126 PMID:17596340 RGD:1627651 NCBI chr 3:177,615,189...177,747,493
Ensembl chr 3:177,618,314...177,747,380 		JBrowse link
G Nos2 nitric oxide synthase 2 onset ISO
IEP 		associated with Anoxia; mouse gene in rat model
associated with Anoxia; protein:increased expression:pulmonary artery
associated with Congenital diaphragmatic hernia; protein:decreased expression:pulmonary artery, endothelium
associated with heart disease; protein:increased expression:endothelial cell
associated with Scleroderma, Systemic; DNA:repeats, SNPs:promoter:(CCTTT), c.-1026C>T, c.-277A>G (human) 		RGD PMID:11104748 PMID:16113050 PMID:16456243 PMID:19912632 PMID:16813666 RGD:4891468, RGD:1580936, RGD:1580940, RGD:5132602, RGD:4891462 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment
susceptibility 		ISO
IDA
IEP
IMP 		DNA:polymorphism:cds:p.E298D (human)
CTD Direct Evidence: marker/mechanism
associated with Beta-Thalassemia;DNA:repeats:intron:
RNA:increased expression:lung
mRNA, protein:increased expression:pulmonary endothelial cell
associated with heart disease; protein:increased expression:endothelial cell
protein:increased expression:arteriole
associated with chronic obstructive pulmonary disease; DNA:polymorphism:cds:p.G894T (human) 		CTD
RGD		 PMID:21144100 PMID:21144100 PMID:29151278 PMID:25699607 PMID:11686901 More... RGD:4892009, RGD:13504742, RGD:11533642, RGD:5132631, RGD:4892004, RGD:5132602, RGD:4892010, RGD:4892039, RGD:4892038, RGD:4892043, RGD:4892042 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Notch1 notch receptor 1 ameliorates ISO RGD PMID:34739767 RGD:155646132 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613 		JBrowse link
G Nox1 NADPH oxidase 1 treatment
ameliorates 		ISO
IEP
IDA 		mRNA,protein:increased expression:lung RGD PMID:24233492 PMID:23706097 PMID:27401289 PMID:24233492 RGD:329955359, RGD:329955579, RGD:329955361, RGD:329955359 NCBI chr  X:101,572,338...101,625,571
Ensembl chr  X:101,572,340...101,595,520 		JBrowse link
G Nox4 NADPH oxidase 4 ISO associated with Anoxia;mRNA, protein:increased expression:lung RGD PMID:18952568 RGD:4762683 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Nppa natriuretic peptide A IDA RGD PMID:2136863 RGD:7247720 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493 		JBrowse link
G Nppb natriuretic peptide B severity IEP
ISO 		protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:20408845 PMID:21351102 PMID:16936438 PMID:16893710 RGD:1642203, RGD:1642205 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310 		JBrowse link
G Pde3a phosphodiesterase 3A IEP mRNA:increased expression:pulmonary artery RGD PMID:12466227 RGD:1582528 NCBI chr 4:175,904,276...176,170,531
Ensembl chr 4:175,904,077...176,169,270 		JBrowse link
G Pde5a phosphodiesterase 5A IMP RGD PMID:19881228 RGD:2314460 NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:213,542,923...213,684,298 		JBrowse link
G Pdgfa platelet derived growth factor subunit A IEP RGD PMID:8447423 RGD:1580847 NCBI chr12:20,759,366...20,780,337
Ensembl chr12:20,754,208...20,780,322 		JBrowse link
G Pdgfb platelet derived growth factor subunit B IEP
ISO 		RGD PMID:8447423 PMID:21819559 PMID:22523431 RGD:1580847, RGD:6482859, RGD:6482831 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 IEP protein:increased expression:lung: RGD PMID:23315792 RGD:9999167 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:128,841,917...128,867,327 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 treatment IDA RGD PMID:22559233 RGD:10400914 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839 		JBrowse link
G Pgf placental growth factor ISO associated with Anemia, Sickle Cell;protein:increased expression:plasma
associated with Heart Defects, Congenital 		RGD PMID:20040765 PMID:20195855 RGD:6483588, RGD:6483610 NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:110,547,153...110,557,747 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21351102 NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:237,823,053...239,103,005 		JBrowse link
G Ptgis prostaglandin I2 synthase treatment
susceptibility 		IMP
ISO 		protein:decreased expression:pulmonary artery (human)
human gene in a rat model
rat gene in a mouse model 		RGD PMID:15684702 PMID:32673988 PMID:12019369 PMID:10359560 RGD:1580695, RGD:401960100, RGD:401959405, RGD:727270 NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP
ISO 		anoxia associated; RGD PMID:18542928 PMID:19577709 RGD:2300276, RGD:5135495 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO RGD PMID:16244766 RGD:1581290 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091 		JBrowse link
G Ramp2 receptor activity modifying protein 2 IEP mRNA:increased expression:heart right ventricle RGD PMID:17437045 RGD:1642678 NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,688,703...86,691,231 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEP
ISO 		protein:altered localization:nucleus, blood vessel endothelial cell, lung
associated with Hypoxia;protein:increased expression:pulmonary artery,smooth muscle tissue (mouse) 		RGD PMID:17934115 PMID:30172777 RGD:2298843, RGD:329955443 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rhoa ras homolog family member A IEP protein:altered localization:membrane, artery, lung
protein:altered localization:pulmonary artery 		RGD PMID:18091588 PMID:16322374 RGD:2298877, RGD:1642819 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302 		JBrowse link
G Ryr1 ryanodine receptor 1 IEP protein:altered localization: : RGD PMID:24692174 RGD:329813077 NCBI chr 1:93,420,078...93,551,305
Ensembl chr 1:93,420,078...93,551,305 		JBrowse link
G Ryr2 ryanodine receptor 2 IEP protein:increased expression:pulmonary artery RGD PMID:22962011 RGD:329813078 NCBI chr17:63,081,527...63,667,141
Ensembl chr17:63,081,527...63,666,705 		JBrowse link
G Ryr3 ryanodine receptor 3 IEP protein:altered localization: : RGD PMID:24692174 RGD:329813077 NCBI chr 3:119,886,129...120,433,465
Ensembl chr 3:119,885,878...120,433,677 		JBrowse link
G Serpina1 serpin family A member 1 IDA
ISO 		protein:decreased expression:serum RGD PMID:1836309 PMID:17444595 RGD:1643154, RGD:1643144 NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:128,619,382...128,660,703 		JBrowse link
G Serpine1 serpin family E member 1 treatment ISO
IDA 		mRNA, protein:decreased expression:lung
DNA:polymorphism:3'utr 		RGD PMID:18337154 PMID:27115515 PMID:20300292 RGD:4143529, RGD:11073610, RGD:4143527 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Slc1a5 solute carrier family 1 member 5 ISO protein:increased expression:myocytes plasma membrane, right ventricle RGD PMID:23794090 RGD:151361111 NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:86,584,949...86,599,054 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 IEP RGD PMID:19043358 RGD:2313622 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24614111 NCBI chr 5:80,830,574...80,859,810
Ensembl chr 5:80,830,389...80,859,809 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 onset
no_association
severity 		ISO
IDA
IMP 		DNA:repeat:promoter (human)
CTD Direct Evidence: marker/mechanism
associated with Heart Septal Defects, Ventricular;DNA:polymorphisms (human)
associated with Anoxia
DNA:polymorphism, repeat:promoter, intron (human)
associated with Pulmonary Disease, Chronic Obstructive;DNA:polymorphism (human) 		CTD
RGD		 PMID:18506000 PMID:16339917 PMID:19886858 PMID:11259539 PMID:19736308 More... RGD:4889442, RGD:4889430, RGD:4889445, RGD:4889432, RGD:4889440, RGD:4889434, RGD:4889432, RGD:4889435, RGD:4889437 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO protein:increased expression:pulmonary artery, smooth muscle cell RGD PMID:17192285 RGD:1642711 NCBI chr 6:18,975,498...19,299,704
Ensembl chr 6:18,946,798...19,287,964 		JBrowse link
G Smad1 SMAD family member 1 IEP
IDA 		protein:decreased phosphorylation:lung, vascular associated smooth muscle cell
protein:decreased expression, increased phosphorylation:lung 		RGD PMID:17347486 PMID:18367643 RGD:1643222, RGD:12903274 NCBI chr19:45,417,430...45,477,962
Ensembl chr19:45,417,433...45,477,957 		JBrowse link
G Smad4 SMAD family member 4 IEP RGD PMID:17347486 PMID:18367643 RGD:1643222, RGD:12903274 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684 		JBrowse link
G Smad6 SMAD family member 6 IEP mRNA:decreased expression:lung RGD PMID:17347486 RGD:1643222 NCBI chr 8:73,345,457...73,414,985
Ensembl chr 8:73,345,460...73,414,149 		JBrowse link
G Smad7 SMAD family member 7 IEP RGD PMID:17347486 RGD:1643222 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849 		JBrowse link
G Smad9 SMAD family member 9 IEP RGD PMID:17347486 RGD:1643222 NCBI chr 2:141,106,668...141,156,477
Ensembl chr 2:141,106,668...141,156,477 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 treatment IMP RGD PMID:19088082 RGD:10042965 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:51,072,209...51,085,936 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20110409 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sox17 SRY-box transcription factor 17 IEP protein:decreased expression:lung (rat) RGD PMID:36913491 RGD:329853317 NCBI chr 5:19,814,345...19,819,859
Ensembl chr 5:19,814,360...19,819,854 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 severity IDA protein:increased phosphorylation:lung RGD PMID:38602915 RGD:407450417 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tac1 tachykinin, precursor 1 IMP RGD PMID:12662901 RGD:5147638 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546 		JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:12662901 RGD:5147638 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:116,478,617...116,647,492 		JBrowse link
G Tacr2 tachykinin receptor 2 IMP RGD PMID:12662901 RGD:5147638 NCBI chr20:30,208,907...30,223,446
Ensembl chr20:30,751,557...30,766,180 		JBrowse link
G Tek TEK receptor tyrosine kinase ISO mRNA, protein:increased expression:lung RGD PMID:16917117 RGD:1601487 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:114,723,006...114,849,991 		JBrowse link
G Tert telomerase reverse transcriptase treatment IEP
ISO 		RGD PMID:24376652 PMID:24376652 RGD:11038675, RGD:11038675 NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111 		JBrowse link
G Tgfa transforming growth factor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18424623 NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 onset ISO DNA:SNPs: :multiple (human)
protein:increased expression:blood 		RGD PMID:18496036 PMID:19324949 RGD:4145273, RGD:4145138 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 IMP RGD PMID:18202349 RGD:2302019 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 IEP mRNA:decreased expression:lung RGD PMID:17392319 RGD:1601116 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469 		JBrowse link
G Thbd thrombomodulin ISO associated with Mixed Connective Tissue Disease RGD PMID:16784493 RGD:1601639 NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:156,306,632...156,320,582 		JBrowse link
G Thpo thrombopoietin ISO protein:increased expression:pulmonary artery, plasma RGD PMID:12487786 RGD:1580087 Ensembl chr11:93,686,834...93,693,320 JBrowse link
G Tlr4 toll-like receptor 4 ISO associated anoxia RGD PMID:20205596 RGD:4144108 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnc tenascin C severity ISO
IEP
IDA 		protein:increased expression:plasma RGD PMID:20528622 PMID:19288153 PMID:15879421 PMID:16782755 RGD:4889562, RGD:4889564, RGD:4889570, RGD:4889567 NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:82,391,340...82,476,131 		JBrowse link
G Tnf tumor necrosis factor ISO associated with pulmonary disease, chronic obstructive; protein:increased expression:serum
CTD Direct Evidence: therapeutic
associated with Pulmonary Edema; protein:increased expression:Bronchoalveolar Lavage Fluid 		CTD
RGD		 PMID:2518282 PMID:16899829 PMID:9628235 PMID:12391106 RGD:4143280, RGD:4142833, RGD:4143422 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 treatment ISO RGD PMID:24334871 RGD:10043360 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 ISO protein:increased expression:lung RGD PMID:24270264 RGD:9586752 NCBI chr 3:128,620,320...128,724,716
Ensembl chr 3:128,620,322...128,696,747 		JBrowse link
G Tph1 tryptophan hydroxylase 1 severity ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:18506000 PMID:17675372 RGD:5686352 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:106,085,953...106,312,484 		JBrowse link
G Tph2 tryptophan hydroxylase 2 severity ISO DNA:SNP: :1473C>G (mouse) RGD PMID:17675372 RGD:5686352 NCBI chr 7:52,571,909...52,676,305
Ensembl chr 7:52,571,911...52,675,639 		JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 ISO RGD PMID:15358862 RGD:1580490 NCBI chr 2:121,409,436...121,487,095
Ensembl chr 2:121,409,436...121,475,823 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 ISO RGD PMID:15358862 RGD:1580490 NCBI chr 8:14,044,216...14,148,808
Ensembl chr 8:14,043,877...14,149,304 		JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 IEP protein:increased expression:pulmonary artery RGD PMID:22962011 RGD:329813078 NCBI chr12:47,599,161...47,638,143
Ensembl chr12:47,599,035...47,638,143 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 treatment IEP RGD PMID:25593290 RGD:38500244 NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:56,398,061...56,404,965 		JBrowse link
G Uts2 urotensin 2 IEP RGD PMID:15042392 RGD:2306848 NCBI chr 5:166,725,471...166,739,063
Ensembl chr 5:166,733,671...166,739,059 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 IEP protein:increased expression:blood vessel endothelium RGD PMID:17934115 RGD:2298843 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO associated with Hypoxia;protein:increased expression:pulmonary artery,smooth muscle tissue (mouse) RGD PMID:30172777 RGD:329955443 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Vegfb vascular endothelial growth factor B ISO RGD PMID:12547729 RGD:1625708 NCBI chr 1:213,601,570...213,607,254
Ensembl chr 1:213,600,966...213,607,152 		JBrowse link
G Vim vimentin IEP protein:increased expression, increased phosphorylation:lung RGD PMID:25593290 RGD:38500244 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
G Vip vasoactive intestinal peptide IDA RGD PMID:22140628 RGD:5685374 NCBI chr 1:44,470,232...44,478,561
Ensembl chr 1:44,470,462...44,478,558 		JBrowse link
G Vwf von Willebrand factor ISO RGD PMID:14507115 RGD:1580645 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757 		JBrowse link
Dursun Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pc3 glucose 6 phosphatase catalytic subunit 3 ISO ClinVar Annotator: match by term: Dursun syndrome ClinVar PMID:22050868 PMID:25492228 PMID:25741868 PMID:27577878 PMID:28492532 More... NCBI chr10:87,146,987...87,151,223
Ensembl chr10:87,647,062...87,653,453 		JBrowse link
HUPRA Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sars1 seryl-tRNA synthetase 1 ISO ClinVar Annotator: match by term: HYPERURICEMIA, PULMONARY HYPERTENSION, RENAL FAILURE, AND ALKALOSIS SYNDROME ClinVar PMID:25741868 PMID:28492532 NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:198,753,675...198,769,365 		JBrowse link
G Sars2 seryl-tRNA synthetase 2, mitochondrial ISO ClinVar Annotator: match by term: HUPRA SYNDROME | ClinVar Annotator: match by term: HYPERURICEMIA, PULMONARY HYPERTENSION, RENAL FAILURE, AND ALKALOSIS SYNDROME | ClinVar Annotator: match by term: SARS2-related condition
DNA:missense mutation:CDS:p.D390G (human) 		OMIM
ClinVar
RGD		 PMID:9536098 PMID:17576681 PMID:21255763 PMID:24034276 PMID:25741868 More... RGD:41410777 NCBI chr 1:93,156,514...93,171,943
Ensembl chr 1:93,156,377...93,168,244 		JBrowse link
Neonatal Pulmonary Hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cps1 carbamoyl-phosphate synthase 1 ISO ClinVar Annotator: match by term: Pulmonary hypertension, neonatal, susceptibility to ClinVar
OMIM		 PMID:8486760 PMID:9536098 PMID:9686343 PMID:9711878 PMID:11388595 More... NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:76,000,754...76,186,734 		JBrowse link
persistent fetal circulation syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 6430548M08Rikl RIKEN cDNA 6430548M08 gene like ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:48,168,651...48,216,571
Ensembl chr19:65,077,790...65,125,177 		JBrowse link
G Adad2 adenosine deaminase domain containing 2 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:47,665,288...47,669,433
Ensembl chr19:64,573,883...64,578,192 		JBrowse link
G Atp2c2 ATPase secretory pathway Ca2+ transporting 2 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:64,662,729...64,719,998
Ensembl chr19:64,662,715...64,719,996 		JBrowse link
G C19h16orf74 similar to human chromosome 16 open reading frame 74 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:48,660,288...48,686,287
Ensembl chr19:65,568,997...65,595,460 		JBrowse link
G C19h16orf95 similar to human chromosome 16 open reading frame 95 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:49,605,818...49,618,466
Ensembl chr19:66,514,447...66,527,014 		JBrowse link
G Cibar2 CBY1 interacting BAR domain containing 2 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:48,217,617...48,229,418
Ensembl chr19:65,125,383...65,138,032 		JBrowse link
G Cotl1 coactosin-like F-actin binding protein 1 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:64,780,309...64,814,629
Ensembl chr19:64,780,322...64,814,840 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:48,721,680...48,727,920
Ensembl chr19:65,630,432...65,636,624 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 ISO CACD, OMIM:265380, DNA:polymorphism:T1405N
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:11407344 PMID:11407344 RGD:1600716 NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:76,000,754...76,186,734 		JBrowse link
G Crispld2 cysteine-rich secretory protein LCCL domain containing 2 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:48,053,153...48,111,485
Ensembl chr19:64,961,771...65,020,349 		JBrowse link
G Dnaaf1 dynein, axonemal, assembly factor 1 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:47,624,534...47,652,314
Ensembl chr19:64,532,860...64,561,435 		JBrowse link
G Emc8 ER membrane protein complex subunit 8 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:65,620,365...65,630,328
Ensembl chr19:65,620,375...65,630,235 		JBrowse link
G Fbxo31 F-box protein 31 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:66,533,437...66,564,674
Ensembl chr19:66,533,437...66,564,674 		JBrowse link
G Fendrr FOXF1 adjacent non-coding developmental regulatory RNA ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar PMID:25741868 NCBI chr19:49,127,225...49,152,780
Ensembl chr19:66,036,856...66,044,268 		JBrowse link
G Foxc2 forkhead box C2 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:66,094,718...66,097,420
Ensembl chr19:66,094,700...66,153,977 		JBrowse link
G Foxf1 forkhead box F1 ISO
ISS 		ClinVar Annotator: match by term: ALVEOLAR CAPILLARY DYSPLASIA WITH MISALIGNMENT OF PULMONARY VEINS AND OTHER CONGENITAL ANOMALIES | ClinVar Annotator: match by term: Alveolar capillary dysplasia with misalignment of pulmonary veins | ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia
OMIM:265380
CTD Direct Evidence: marker/mechanism 		OMIM
ClinVar
MouseDO
CTD		 PMID:15520767 PMID:19500772 PMID:23505205 PMID:24033266 PMID:25741868 More... NCBI chr19:66,062,635...66,066,427
Ensembl chr19:66,062,369...66,066,428 		JBrowse link
G Foxl1 forkhead box L1 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:49,197,269...49,200,682 JBrowse link
G Gins2 GINS complex subunit 2 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:65,535,492...65,548,270
Ensembl chr19:65,535,492...65,548,052 		JBrowse link
G Gse1 Gse1 coiled-coil protein ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:65,182,678...65,538,183
Ensembl chr19:65,446,263...65,538,176 		JBrowse link
G Hsdl1 hydroxysteroid dehydrogenase like 1 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:64,524,435...64,540,527
Ensembl chr19:64,525,891...64,540,762 		JBrowse link
G Irf8 interferon regulatory factor 8 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:65,699,284...65,721,066
Ensembl chr19:65,699,284...65,721,062 		JBrowse link
G Itgam integrin subunit alpha M ISO DNA:missense mutation:CDS:p.E1071D (human) RGD PMID:32054482 RGD:329853760 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943 		JBrowse link
G Jph3 junctophilin 3 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:66,702,497...66,763,948
Ensembl chr19:66,702,680...66,763,937 		JBrowse link
G Kcng4 potassium voltage-gated channel modifier subfamily G member 4 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:47,677,307...47,689,410
Ensembl chr19:64,585,954...64,597,888 		JBrowse link
G Klhl36 kelch-like family member 36 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:47,921,590...47,942,627
Ensembl chr19:64,836,877...64,851,250 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Mbtps1 membrane-bound transcription factor peptidase, site 1 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:64,470,245...64,521,438
Ensembl chr19:64,470,545...64,521,342 		JBrowse link
G Meak7 MTOR associated protein, eak-7 homolog ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:47,813,899...47,836,830
Ensembl chr19:64,722,528...64,751,330 		JBrowse link
G Mlycd malonyl-CoA decarboxylase ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:64,356,582...64,372,447
Ensembl chr19:64,356,223...64,372,446 		JBrowse link
G Mthfsd methenyltetrahydrofolate synthetase domain containing ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:49,164,266...49,178,233
Ensembl chr19:66,056,560...66,086,925 		JBrowse link
G Necab2 N-terminal EF-hand calcium binding protein 2 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:47,501,351...47,527,722
Ensembl chr19:64,409,751...64,436,369 		JBrowse link
G Nos3 nitric oxide synthase 3 ISS OMIM:265380 MouseDO NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:64,380,336...64,409,165
Ensembl chr19:64,401,173...64,409,162 		JBrowse link
G Pten phosphatase and tensin homolog ISS OMIM:265380 MouseDO NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Slc38a8 solute carrier family 38, member 8 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:64,432,524...64,468,852
Ensembl chr19:64,437,013...64,463,960 		JBrowse link
G Stra6 signaling receptor and transporter of retinol STRA6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17273977 NCBI chr 8:67,444,757...67,464,719
Ensembl chr 8:67,444,742...67,464,720 		JBrowse link
G Taf1c TATA-box binding protein associated factor, RNA polymerase 1 subunit C ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:64,561,079...64,567,599
Ensembl chr19:64,560,562...64,567,599 		JBrowse link
G Usp10 ubiquitin specific peptidase 10 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:64,881,255...64,923,522
Ensembl chr19:64,881,315...64,923,519 		JBrowse link
G Wfdc1 WAP four-disulfide core domain 1 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:64,628,689...64,647,739
Ensembl chr19:64,607,794...64,648,028 		JBrowse link
G Zcchc14 zinc finger CCHC-type containing 14 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:49,674,185...49,718,004
Ensembl chr19:66,582,800...66,627,136 		JBrowse link
G Zdhhc7 zinc finger DHHC-type palmitoyltransferase 7 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chr19:65,048,140...65,065,286
Ensembl chr19:65,037,310...65,065,286 		JBrowse link
primary pulmonary hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl-interactor 2 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:61,827,186...61,905,703
Ensembl chr 9:69,321,150...69,490,597 		JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:75,783,689...75,822,164 		JBrowse link
G Acvrl1 activin A receptor like type 1 ISO ClinVar Annotator: match by term: Heritable pulmonary arterial hypertension ClinVar PMID:25741868 PMID:28492532 PMID:31727138 NCBI chr 7:134,117,917...134,135,306
Ensembl chr 7:134,118,024...134,135,305 		JBrowse link
G Adam23 ADAM metallopeptidase domain 23 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:64,862,649...65,009,718
Ensembl chr 9:72,356,479...72,503,545 		JBrowse link
G Adora2a adenosine A2a receptor ISS OMIM:178600 | OMIM:265400 | OMIM:615342 | OMIM:615343 | OMIM:615344 MouseDO NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802 		JBrowse link
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:16429395 PMID:16429403 PMID:27453251 PMID:28492532 PMID:29743074 NCBI chr 9:68,107,310...68,180,192
Ensembl chr 9:68,107,528...68,179,660 		JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B ISO ClinVar Annotator: match by term: Idiopathic pulmonary arterial hypertension ClinVar PMID:22374147 PMID:25741868 PMID:25758993 PMID:28492532 NCBI chr 2:233,211,525...233,544,344
Ensembl chr 2:233,211,525...233,544,311 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 ISO
ISS 		CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Idiopathic and/or familial pulmonary arterial hypertension | ClinVar Annotator: match by term: Primary pulmonary hypertension | ClinVar Annotator: match by term: Pulmonary hypertension, primary, dexfenfluramine-associated | ClinVar Annotator: match by term: Pulmonary hypertension, primary, fenfluramine-associated
OMIM:178600 | OMIM:265400 | OMIM:615342 | OMIM:615343 | OMIM:615344 		CTD
ClinVar
MouseDO		 PMID:3291115 PMID:9536098 PMID:10903931 PMID:10973254 PMID:11015450 More... NCBI chr 9:68,685,942...68,801,353
Ensembl chr 9:68,685,988...68,801,350 		JBrowse link
G Carf calcium responsive transcription factor ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:68,996,419...69,046,480
Ensembl chr 9:68,996,250...69,046,479 		JBrowse link
G Cav1 caveolin 1 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740 		JBrowse link
G Ccnyl1 cyclin Y-like 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:73,565,484...73,601,926
Ensembl chr 9:73,565,402...73,601,922 		JBrowse link
G Cd28 Cd28 molecule ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:69,545,326...69,689,192 		JBrowse link
G Cdk15 cyclin-dependent kinase 15 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:16429395 PMID:16429403 PMID:27453251 PMID:28492532 PMID:29743074 NCBI chr 9:68,205,759...68,299,218
Ensembl chr 9:68,205,678...68,293,579 		JBrowse link
G Cmklr2 chemerin chemokine-like receptor 2 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:64,583,310...64,617,883
Ensembl chr 9:72,078,608...72,116,257 		JBrowse link
G Cpo carboxypeptidase O ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:65,319,996...65,338,250 JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:76,000,754...76,186,734 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Cryga crystallin, gamma A ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:66,482,176...66,484,638
Ensembl chr 9:73,975,914...74,003,290 		JBrowse link
G Crygb crystallin, gamma B ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:66,461,460...66,463,520
Ensembl chr 9:73,955,204...73,957,264 		JBrowse link
G Crygc crystallin, gamma C ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:66,451,591...66,453,626
Ensembl chr 9:73,945,334...73,947,367 		JBrowse link
G Crygd crystallin, gamma D ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:66,442,057...66,443,668
Ensembl chr 9:73,935,795...73,937,808 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:69,813,265...69,819,973 		JBrowse link
G Cyp20a1 cytochrome P450, family 20, subfamily a, polypeptide 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:61,755,804...61,805,123
Ensembl chr 9:69,249,844...69,299,291 		JBrowse link
G Dytn dystrotelin ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:65,037,378...65,098,549
Ensembl chr 9:72,531,317...72,594,656 		JBrowse link
G Eef1b2 eukaryotic translation elongation factor 1 beta 2 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:72,074,091...72,076,591
Ensembl chr 9:72,073,802...72,076,589 		JBrowse link
G Fam117b family with sequence similarity 117, member B ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:61,340,284...61,418,531
Ensembl chr 9:68,834,354...68,902,543 		JBrowse link
G Fastkd2 FAST kinase domains 2 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:72,659,961...72,681,986
Ensembl chr 9:72,661,764...72,721,338 		JBrowse link
G Fbxo32 F-box protein 32 ISO mRNA:increased expression:vastus lateralis RGD PMID:23972212 RGD:329812002 NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 ISO protein:increased expression:lung (human) RGD PMID:29722558 RGD:155791445 NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:194,175,705...194,280,914 		JBrowse link
G Foxf1 forkhead box F1 ISO ClinVar Annotator: match by term: Idiopathic and/or familial pulmonary arterial hypertension ClinVar PMID:19500772 PMID:19592680 PMID:19812545 PMID:20425831 PMID:22766610 More... NCBI chr19:66,062,635...66,066,427
Ensembl chr19:66,062,369...66,066,428 		JBrowse link
G Fzd5 frizzled class receptor 5 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:73,606,860...73,614,039
Ensembl chr 9:73,606,860...73,618,612 		JBrowse link
G Fzd7 frizzled class receptor 7 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:16429395 PMID:16429403 PMID:27453251 PMID:28492532 PMID:29743074 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:68,411,259...68,432,585 		JBrowse link
G Hdac1 histone deacetylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22711276 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387 		JBrowse link
G Hdac4 histone deacetylase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22711276 NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:99,955,116...100,197,637 		JBrowse link
G Hdac5 histone deacetylase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22711276 NCBI chr10:87,653,139...87,688,078
Ensembl chr10:87,652,656...87,694,244 		JBrowse link
G Ica1l islet cell autoantigen 1-like ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:61,410,959...61,469,884
Ensembl chr 9:68,906,148...68,963,692 		JBrowse link
G Icos inducible T-cell co-stimulator ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:69,862,042...69,900,864
Ensembl chr 9:69,877,785...69,900,960 		JBrowse link
G Id1 inhibitor of DNA binding 1 ISO protein:decreased expression:lung, wall of arteriole (human) RGD PMID:20522807 RGD:9686087 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:74,027,892...74,049,555 		JBrowse link
G Ino80d INO80 complex subunit D ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:71,940,941...72,007,879
Ensembl chr 9:71,951,031...72,040,232 		JBrowse link
G Kansl1l KAT8 regulatory NSL complex subunit 1-like ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:68,211,151...68,316,992
Ensembl chr 9:75,661,233...75,766,745 		JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 6:31,483,129...31,519,061
Ensembl chr 6:31,483,140...31,519,061 		JBrowse link
G Klf7 KLF transcription factor 7 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:72,927,485...73,020,167
Ensembl chr 9:72,933,136...73,020,056 		JBrowse link
G Lancl1 LanC like glutathione S-transferase 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:68,515,052...68,548,646
Ensembl chr 9:75,968,286...76,003,475 		JBrowse link
G Map2 microtubule-associated protein 2 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459 		JBrowse link
G Mdh1b malate dehydrogenase 1B ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:65,120,370...65,168,008
Ensembl chr 9:72,613,340...72,661,745 		JBrowse link
G Mettl21a methyltransferase 21A, HSPA lysine ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:65,934,253...65,999,964
Ensembl chr 9:73,471,813...73,481,339 		JBrowse link
G Mfn1 mitofusin 1 ISO protein:decreased expression:vastus lateralis RGD PMID:23972212 RGD:329812002 NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190 		JBrowse link
G Mfn2 mitofusin 2 ISO protein:decreased expression:vastus lateralis RGD PMID:23972212 RGD:329812002 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495 		JBrowse link
G Mir23a microRNA 23a ISO RNA:increased expression:serum RGD PMID:25815108 RGD:155882560 NCBI chr19:23,954,997...23,955,071 JBrowse link
G Myl1 myosin, light chain 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 Ensembl chr 9:75,887,227...75,907,971 JBrowse link
G Nbeal1 neurobeachin-like 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:61,575,154...61,743,896
Ensembl chr 9:69,070,247...69,231,307 		JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:72,040,286...72,073,605
Ensembl chr 9:72,040,090...72,073,605 		JBrowse link
G Nop58 NOP58 ribonucleoprotein ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:16429395 PMID:16429403 PMID:27453251 PMID:28492532 PMID:29743074 NCBI chr 9:68,614,992...68,638,911
Ensembl chr 9:68,615,010...68,638,909 		JBrowse link
G Nrp2 neuropilin 2 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:71,616,602...71,731,869
Ensembl chr 9:71,616,657...71,731,871 		JBrowse link
G Pard3b par-3 family cell polarity regulator beta ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:70,532,358...71,561,044
Ensembl chr 9:70,532,644...71,560,554 		JBrowse link
G Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:66,563,747...66,657,873
Ensembl chr 9:74,057,514...74,151,610 		JBrowse link
G Plekhm3 pleckstrin homology domain containing M3 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:73,659,998...73,819,079
Ensembl chr 9:73,664,817...73,799,503 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISS OMIM:178600 | OMIM:265400 | OMIM:615342 | OMIM:615343 | OMIM:615344 MouseDO NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ptgis prostaglandin I2 synthase ISO DNA:SNP, missense mutations:intron 4, CDS:c.521+1G>A, p.R252Q (c.755G>A), p.A447T (c.1339G>A) (, rs759344518, rs146531327) (human) RGD PMID:32236489 RGD:401901150 NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650 		JBrowse link
G Pth2r parathyroid hormone 2 receptor ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:66,706,050...66,810,601
Ensembl chr 9:74,199,785...74,304,326 		JBrowse link
G Raph1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:61,907,476...61,990,170
Ensembl chr 9:69,401,517...69,484,019 		JBrowse link
G Rfc1 replication factor C subunit 1 ISO mRNA:increased expression:lung (human) RGD PMID:37410515 RGD:401940160 NCBI chr14:43,319,768...43,395,028
Ensembl chr14:43,319,935...43,395,026 		JBrowse link
G Rpe ribulose-5-phosphate-3-epimerase ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:75,640,867...75,661,009
Ensembl chr 9:75,640,982...75,661,643 		JBrowse link
G Ryr1 ryanodine receptor 1 ISO protein:increased phosphorylation:vastus lateralis RGD PMID:23972212 RGD:329812002 NCBI chr 1:93,420,078...93,551,305
Ensembl chr 1:93,420,078...93,551,305 		JBrowse link
G Smad9 SMAD family member 9 ISO
ISS 		CTD Direct Evidence: marker/mechanism
OMIM:178600 | OMIM:265400 | OMIM:615342 | OMIM:615343 | OMIM:615344 		CTD
MouseDO		 NCBI chr 2:141,106,668...141,156,477
Ensembl chr 2:141,106,668...141,156,477 		JBrowse link
G Sox17 SRY-box transcription factor 17 ISO protein:decreased expression:pulmonary artery (human) RGD PMID:36919784 RGD:329853737 NCBI chr 5:19,814,345...19,819,859
Ensembl chr 5:19,814,360...19,819,854 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:16429395 PMID:16429403 PMID:27453251 PMID:28492532 PMID:29743074 NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:68,572,911...68,602,890 		JBrowse link
G Tnfsf4 TNF superfamily member 4 ISS OMIM:178600 | OMIM:265400 | OMIM:615342 | OMIM:615343 | OMIM:615344 MouseDO NCBI chr13:76,256,654...76,280,133
Ensembl chr13:76,256,654...76,280,133 		JBrowse link
G Trim63 tripartite motif containing 63 ISO mRNA, protein:increased expression:vastus lateralis RGD PMID:23972212 RGD:329812002 NCBI chr 5:151,817,209...151,831,026
Ensembl chr 5:151,817,225...151,831,058 		JBrowse link
G Unc80 unc-80 homolog, NALCN channel complex subunit ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:68,011,940...68,190,135
Ensembl chr 9:75,461,599...75,639,842 		JBrowse link
G Vip vasoactive intestinal peptide ISS OMIM:178600 | OMIM:265400 | OMIM:615342 | OMIM:615343 | OMIM:615344 MouseDO NCBI chr 1:44,470,232...44,478,561
Ensembl chr 1:44,470,462...44,478,558 		JBrowse link
G Wdr12 WD repeat domain 12 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:68,969,547...68,996,811
Ensembl chr 9:68,969,547...68,996,811 		JBrowse link
G Zdbf2 zinc finger, DBF-type containing 2 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chr 9:64,672,974...64,748,446
Ensembl chr 9:72,203,598...72,242,287 		JBrowse link
primary pulmonary hypertension 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:9245985 PMID:12700602 PMID:14684682 PMID:15024723 PMID:15879500 More... NCBI chr 7:134,117,917...134,135,306
Ensembl chr 7:134,118,024...134,135,305 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 ISO ClinVar Annotator: match by term: BMPR2-related disorder | ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 | ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia OMIM
ClinVar		 PMID:3291115 PMID:9536098 PMID:9886286 PMID:10903931 PMID:10973254 More... NCBI chr 9:68,685,942...68,801,353
Ensembl chr 9:68,685,988...68,801,350 		JBrowse link
G Eng endoglin ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:16690726 PMID:16754821 PMID:18498373 PMID:23298310 PMID:24033266 More... NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:36,326,202...36,370,933 		JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:20018952 PMID:21685056 PMID:23861362 PMID:24068186 PMID:25076992 More... NCBI chr 4:161,040,853...161,044,311
Ensembl chr 4:160,996,950...161,044,408 		JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:23883380 NCBI chr 6:31,483,129...31,519,061
Ensembl chr 6:31,483,140...31,519,061 		JBrowse link
G Nop58 NOP58 ribonucleoprotein ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:23579436 NCBI chr 9:68,614,992...68,638,911
Ensembl chr 9:68,615,010...68,638,909 		JBrowse link
G Pah phenylalanine hydroxylase ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:1301187 PMID:1682234 PMID:1769645 PMID:2044609 PMID:2574153 More... NCBI chr 7:23,793,096...23,885,631
Ensembl chr 7:23,792,781...23,885,627 		JBrowse link
G Smad1 SMAD family member 1 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:21898662 NCBI chr19:45,417,430...45,477,962
Ensembl chr19:45,417,433...45,477,957 		JBrowse link
G Smad4 SMAD family member 4 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:21898662 PMID:24728327 PMID:25502805 PMID:25741868 PMID:28492532 More... NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684 		JBrowse link
G Smad9 SMAD family member 9 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:25741868 NCBI chr 2:141,106,668...141,156,477
Ensembl chr 2:141,106,668...141,156,477 		JBrowse link
G Snord11 small nucleolar RNA, C/D box 11 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:23579436 NCBI chr 9:61,137,715...61,137,798
Ensembl chr 9:68,631,817...68,631,900 		JBrowse link
G Snord11b small nucleolar RNA, C/D box 11B ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:23579436 NCBI chr 9:61,137,168...61,137,247
Ensembl chr 9:68,631,270...68,631,349 		JBrowse link
G Snord70 small nucleolar RNA, C/D box 70 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:23579436 NCBI chr 9:61,125,974...61,126,060
Ensembl chr 9:68,620,078...68,620,164 		JBrowse link
G Snord70b small nucleolar RNA, C/D box 70B ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:23579436 NCBI chr 9:61,126,745...61,126,828
Ensembl chr 9:68,620,849...68,620,932 		JBrowse link
G Tbx4 T-box transcription factor 4 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:9536098 PMID:15106123 PMID:16199547 PMID:17576681 PMID:23592887 More... NCBI chr10:70,730,686...70,760,829
Ensembl chr10:71,197,727...71,258,218 		JBrowse link
primary pulmonary hypertension 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad9 SMAD family member 9 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 2 | ClinVar Annotator: match by term: SMAD9-related condition OMIM
ClinVar		 PMID:9536098 PMID:16199547 PMID:17576681 PMID:19211612 PMID:19419974 More... NCBI chr 2:141,106,668...141,156,477
Ensembl chr 2:141,106,668...141,156,477 		JBrowse link
primary pulmonary hypertension 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1b bone morphogenetic protein receptor type 1B ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 3 ClinVar PMID:25741868 PMID:28492532 NCBI chr 2:233,211,525...233,544,344
Ensembl chr 2:233,211,525...233,544,311 		JBrowse link
G Cav1 caveolin 1 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 3 OMIM
ClinVar		 PMID:22474227 PMID:25741868 PMID:28492532 PMID:29231014 PMID:30029678 More... NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740 		JBrowse link
primary pulmonary hypertension 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnk3 potassium two pore domain channel subfamily K member 3 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 4 OMIM
ClinVar		 PMID:9536098 PMID:17576681 PMID:23883380 PMID:24033266 PMID:25741868 More... NCBI chr 6:31,483,129...31,519,061
Ensembl chr 6:31,483,140...31,519,061 		JBrowse link
primary pulmonary hypertension 5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a3 ATPase 13A3 ISO ClinVar Annotator: match by term: ATP13A3-related condition | ClinVar Annotator: match by term: Pulmonary hypertension, primary, autosomal recessive OMIM
ClinVar		 PMID:25741868 PMID:28492532 PMID:30679663 PMID:31727138 PMID:34493544 More... NCBI chr11:70,364,998...70,442,005
Ensembl chr11:83,870,218...83,944,662 		JBrowse link
primary pulmonary hypertension 6 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Capns1 calpain, small subunit 1 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 6 ClinVar
OMIM		 PMID:21972389 PMID:38230350 NCBI chr 1:94,572,083...94,582,332
Ensembl chr 1:94,572,083...94,583,368 		JBrowse link
Pulmonary Arterial Hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:10204114 PMID:10685980 PMID:16380471 PMID:16416420 PMID:17539904 More... NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:105,734,992...105,815,982 		JBrowse link
G Abi2 abl-interactor 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:61,827,186...61,905,703
Ensembl chr 9:69,321,150...69,490,597 		JBrowse link
G Acvrl1 activin A receptor like type 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:10767348 PMID:11484689 PMID:12114496 PMID:14684682 PMID:15024723 More... NCBI chr 7:134,117,917...134,135,306
Ensembl chr 7:134,118,024...134,135,305 		JBrowse link
G Ahr aryl hydrocarbon receptor severity ISO CTD Direct Evidence: marker/mechanism
protein:increased activity:serum (human) 		CTD
RGD		 PMID:33836606 PMID:33836606 RGD:401940192 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Ahsp alpha hemoglobin stabilizing protein ISO mRNA:altered expression: (human) RGD PMID:35710932 RGD:329961295 NCBI chr 1:182,879,901...182,885,508
Ensembl chr 1:192,310,244...192,315,942 		JBrowse link
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:68,107,310...68,180,192
Ensembl chr 9:68,107,528...68,179,660 		JBrowse link
G Aox1 aldehyde oxidase 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:67,073,821...67,152,980 		JBrowse link
G Apln apelin treatment ISO RGD PMID:23867624 RGD:329848996 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:132,081,759...132,091,246 		JBrowse link
G Atp13a3 ATPase 13A3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25741868 PMID:28492532 PMID:30679663 PMID:31727138 PMID:34493544 More... NCBI chr11:70,364,998...70,442,005
Ensembl chr11:83,870,218...83,944,662 		JBrowse link
G Axin2 axin 2 exacerbates IMP RGD PMID:28694128 RGD:151356920 NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575 		JBrowse link
G Bmp7 bone morphogenetic protein 7 IEP protein:increased expression:lung, pulmonary artery (rat) RGD PMID:31542483 RGD:155888480 NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:182,052,337...182,135,137 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary arterial hypertension associated with congenital heart disease ClinVar PMID:24121792 PMID:25186627 PMID:25741868 PMID:25980754 PMID:26467025 More... NCBI chr16:9,740,751...9,786,861
Ensembl chr16:9,742,875...9,786,861 		JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary arterial hypertension associated with congenital heart disease ClinVar PMID:25741868 PMID:28492532 PMID:30029678 NCBI chr 2:233,211,525...233,544,344
Ensembl chr 2:233,211,525...233,544,311 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 treatment ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary arterial hypertension associated with congenital heart disease 		CTD
ClinVar
RGD		 PMID:3291115 PMID:9536098 PMID:9886286 PMID:10903931 PMID:10973254 More... RGD:329848996 NCBI chr 9:68,685,942...68,801,353
Ensembl chr 9:68,685,988...68,801,350 		JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:67,424,860...67,438,656
Ensembl chr 9:67,424,866...67,439,684 		JBrowse link
G C2cd6 C2 calcium dependent domain containing 6 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:60,434,926...60,530,842
Ensembl chr 9:67,929,082...68,024,960 		JBrowse link
G Carf calcium responsive transcription factor ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:68,996,419...69,046,480
Ensembl chr 9:68,996,250...69,046,479 		JBrowse link
G Casp8 caspase 8 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Cav1 caveolin 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension associated with congenital heart disease ClinVar PMID:25741868 PMID:28492532 PMID:30029678 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740 		JBrowse link
G Cd28 Cd28 molecule ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:69,545,326...69,689,192 		JBrowse link
G Cdh2 cadherin 2 ISO mRNA:increased expression:lung RGD PMID:25593290 RGD:38500244 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288 		JBrowse link
G Cdk15 cyclin-dependent kinase 15 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:68,205,759...68,299,218
Ensembl chr 9:68,205,678...68,293,579 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434 		JBrowse link
G Clk1 CDC-like kinase 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:67,441,962...67,453,180
Ensembl chr 9:67,441,952...67,451,187 		JBrowse link
G Cp ceruloplasmin ISO associated with systemic scleroderma;protein:increased expression:serum RGD PMID:32630589 RGD:401827129 NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment IDA RGD PMID:33760143 RGD:401960860 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:69,813,265...69,819,973 		JBrowse link
G Ctnnd1 catenin delta 1 ISO protein:decreased expression:lung RGD PMID:25593290 RGD:38500244 NCBI chr 3:90,090,025...90,141,247
Ensembl chr 3:90,090,564...90,141,189 		JBrowse link
G Cyp20a1 cytochrome P450, family 20, subfamily a, polypeptide 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:61,755,804...61,805,123
Ensembl chr 9:69,249,844...69,299,291 		JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 exacerbates IMP compared to wild type RGD PMID:31402164 RGD:151347602 NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:237,327,766...237,460,626 		JBrowse link
G Ddah1em1Ywxu dimethylarginine dimethylaminohydrolase 1; CRISPR/Cas9 induced mutant 1, Ywxu exacerbates IMP compared to wild type RGD PMID:31402164 RGD:151347602
G Dhps deoxyhypusine synthase ISO protein:increased expression:pulmonary arterial smooth muscle: RGD PMID:38261723 RGD:597621636 NCBI chr19:23,082,454...23,086,544
Ensembl chr19:39,987,324...39,991,432 		JBrowse link
G Dohh deoxyhypusine hydroxylase ISO protein:increased expression:pulmonary arterial smooth muscle, pulmonary artery, right ventricle: RGD PMID:38261723 RGD:597621636 NCBI chr 7:8,972,202...8,977,025
Ensembl chr 7:8,972,202...8,977,025 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:12215525 PMID:24135949 PMID:24292273 PMID:24310610 PMID:25741868 More... NCBI chr 3:125,810,207...125,895,574
Ensembl chr 3:125,810,060...125,895,574 		JBrowse link
G Eif5a eukaryotic translation initiation factor 5A ISO protein:increased expression:pulmonary arterial smooth muscle, pulmonary artery, right ventricle RGD PMID:38261723 RGD:597621636 NCBI chr10:55,138,821...55,143,272
Ensembl chr10:55,138,823...55,143,330 		JBrowse link
G Eng endoglin ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary arterial hypertension associated with congenital heart disease ClinVar PMID:10625079 PMID:15517393 PMID:15521985 PMID:15879500 PMID:16705692 More... NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:36,326,202...36,370,933 		JBrowse link
G Fam117b family with sequence similarity 117, member B ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:61,340,284...61,418,531
Ensembl chr 9:68,834,354...68,902,543 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase ISO RGD PMID:30107138 RGD:329349307 NCBI chr15:16,365,401...17,872,901
Ensembl chr15:16,747,338...17,872,621 		JBrowse link
G Flacc1 flagellum associated containing coiled-coil domains 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:60,315,581...60,343,692
Ensembl chr 9:67,809,739...67,837,793 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase IEP protein:decreased expression:lung RGD PMID:34310344 RGD:329845886 NCBI chr19:31,456,749...31,865,011
Ensembl chr19:31,522,293...31,864,957 		JBrowse link
G Fzd7 frizzled class receptor 7 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:68,411,259...68,432,585 		JBrowse link
G Gdf2 growth differentiation factor 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25741868 PMID:26801773 PMID:28492532 PMID:31661308 PMID:31727138 NCBI chr16:9,255,430...9,261,429
Ensembl chr16:9,261,662...9,267,677 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO associated with systemic scleroderma;protein:decreased expression:serum RGD PMID:32630589 RGD:401827129 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405 		JBrowse link
G H19 H19 imprinted maternally expressed transcript ameliorates
treatment 		ISO
IEP 		RGD PMID:30547791 PMID:30240970 RGD:155882573, RGD:156430315 NCBI chr 1:207,160,175...207,162,851 JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISO protein:increased expression:endothelium, smooth muscle, pulmonary artery RGD PMID:28473438 RGD:329955562 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:91,052,432...91,418,583 		JBrowse link
G Hycc2 hyccin PI4KA lipid kinase complex subunit 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:67,551,064...67,623,353
Ensembl chr 9:67,551,064...67,587,186 		JBrowse link
G Ica1l islet cell autoantigen 1-like ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:61,410,959...61,469,884
Ensembl chr 9:68,906,148...68,963,692 		JBrowse link
G Icos inducible T-cell co-stimulator ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:69,862,042...69,900,864
Ensembl chr 9:69,877,785...69,900,960 		JBrowse link
G Ifng interferon gamma treatment IEP RGD PMID:23867624 RGD:329848996 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor treatment IEP RGD PMID:30240970 RGD:156430315 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664 		JBrowse link
G Il2 interleukin 2 treatment IEP RGD PMID:23867624 RGD:329848996 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Impa1 inositol monophosphatase 1 ISO RGD PMID:30604625 RGD:126781711 NCBI chr 2:91,462,781...91,484,057
Ensembl chr 2:93,370,299...93,391,468 		JBrowse link
G Itga5 integrin subunit alpha 5 ISO mRNA:increased expression:lung RGD PMID:25593290 RGD:38500244 NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:136,358,097...136,381,305 		JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:23861362 PMID:25741868 PMID:28492532 NCBI chr 4:161,040,853...161,044,311
Ensembl chr 4:160,996,950...161,044,408 		JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 6:31,483,129...31,519,061
Ensembl chr 6:31,483,140...31,519,061 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 ameliorates IMP RGD PMID:28679649 RGD:329955564 NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:89,086,814...89,102,275 		JBrowse link
G Kctd18 potassium channel tetramerization domain containing 18 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:59,502,220...59,566,857
Ensembl chr 9:66,996,447...67,061,069 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 treatment IEP RGD PMID:35582418 RGD:155804297 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012 		JBrowse link
G Mir140 microRNA 140 severity ISO miRNA:decreased expression:blood (human) RGD PMID:27214554 RGD:329337371 NCBI chr19:52,375,293...52,375,391
Ensembl chr19:52,375,293...52,375,391 		JBrowse link
G Mir143 microRNA 143 ameliorates ISO RNA:increased expression:pulmonary smooth muscle cell: RGD PMID:26311719 PMID:26311719 RGD:11537224, RGD:11537224 NCBI chr18:57,371,349...57,371,453 JBrowse link
G Mir17 microRNA 17 severity ISO miRNA:increased expression:blood RGD PMID:32600075 RGD:329349306 NCBI chr15:98,587,848...98,587,931
Ensembl chr15:98,587,848...98,587,931 		JBrowse link
G Mir200a microRNA 200a treatment IEP RGD PMID:30240970 RGD:156430315 NCBI chr 5:171,930,717...171,930,805 JBrowse link
G Mir221 microRNA 221 ameliorates ISO
IMP
IEP 		RNA:increased expression:lung,pulmonary artery smooth muscle cell RGD PMID:28694128 PMID:28694128 PMID:28694128 RGD:151356920, RGD:151356920, RGD:151356920 NCBI chr  X:6,023,182...6,023,290
Ensembl chr  X:6,023,182...6,023,290 		JBrowse link
G Mir675 microRNA 675 treatment IEP RGD PMID:30240970 RGD:156430315 NCBI chr 1:197,732,275...197,732,358 JBrowse link
G Mpp4 MAGUK p55 scaffold protein 4 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:60,569,734...60,613,035
Ensembl chr 9:68,063,867...68,106,128 		JBrowse link
G Nbeal1 neurobeachin-like 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:61,575,154...61,743,896
Ensembl chr 9:69,070,247...69,231,307 		JBrowse link
G Ndufb3 NADH:ubiquinone oxidoreductase subunit B3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:60,129,240...60,139,452
Ensembl chr 9:67,623,614...67,633,613 		JBrowse link
G Nif3l1 NGG1 interacting factor 3 like 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:59,980,101...60,001,490
Ensembl chr 9:67,474,351...67,494,350 		JBrowse link
G Nnmt nicotinamide N-methyltransferase IEP protein:increased activity,altered activity:lung, liver (rat) RGD PMID:27581040 RGD:401793717 NCBI chr 8:57,820,156...57,851,301
Ensembl chr 8:57,825,464...57,843,174 		JBrowse link
G Nop58 NOP58 ribonucleoprotein ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:68,614,992...68,638,911
Ensembl chr 9:68,615,010...68,638,909 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment ISO RGD PMID:23867624 RGD:329848996 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Notch1 notch receptor 1 ISO protein:decreased expression:endothelial cell, nucleus:
ClinVar Annotator: match by term: Pulmonary arterial hypertension 		ClinVar
RGD		 PMID:15472075 PMID:16614245 PMID:18593716 PMID:19245433 PMID:19635999 More... RGD:155646132 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613 		JBrowse link
G Notch3 notch receptor 3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:22006983 PMID:22153900 PMID:22159056 PMID:24086431 PMID:25741868 More... NCBI chr 7:11,783,550...11,834,585
Ensembl chr 7:11,784,272...11,834,778 		JBrowse link
G Orc2 origin recognition complex, subunit 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:67,496,097...67,532,548
Ensembl chr 9:67,496,825...67,526,649 		JBrowse link
G Park7 Parkinsonism associated deglycase exacerbates IMP RGD PMID:29069575 RGD:151347449 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825 		JBrowse link
G Pdcd4 programmed cell death 4 treatment IEP RGD PMID:30240970 RGD:156430315 NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189 		JBrowse link
G Phf6 PHD finger protein 6 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25741868 NCBI chr  X:137,576,214...137,619,297
Ensembl chr  X:137,576,235...137,615,914 		JBrowse link
G Ppil3 peptidylprolyl isomerase like 3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:67,460,594...67,474,325
Ensembl chr 9:67,460,595...67,474,251 		JBrowse link
G Ptgis prostaglandin I2 synthase treatment
susceptibility 		ISO
IEP 		human gene in a rat model
DNA:repeat, SNPs:promoter, intron: , 185C>T, 325C>A ( , rs5582, rs116939356) (human) 		RGD PMID:17635855 PMID:23841984 PMID:24605778 PMID:11034952 PMID:18612919 RGD:401901195, RGD:401959742, RGD:401959406, RGD:401959335, RGD:401901264 NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650 		JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D ISO mRNA:decreased expression:blood, pulmonary artery (human) RGD PMID:35848503 RGD:401976433 NCBI chr 5:95,093,221...97,415,498
Ensembl chr 5:95,095,858...96,178,903 		JBrowse link
G Raph1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:61,907,476...61,990,170
Ensembl chr 9:69,401,517...69,484,019 		JBrowse link
G Selenop selenoprotein P ISO associated with systemic scleroderma;protein:decreased expression:serum RGD PMID:32630589 RGD:401827129 NCBI chr 2:54,225,736...54,236,022
Ensembl chr 2:54,225,152...54,236,019 		JBrowse link
G Sgo2 shugoshin 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:67,032,083...67,067,439
Ensembl chr 9:67,042,833...67,068,152 		JBrowse link
G Smad4 SMAD family member 4 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25559809 PMID:25741868 PMID:26467025 PMID:28492532 PMID:29684080 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684 		JBrowse link
G Smad9 SMAD family member 9 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension associated with congenital heart disease ClinVar PMID:25741868 PMID:28492532 PMID:30029678 NCBI chr 2:141,106,668...141,156,477
Ensembl chr 2:141,106,668...141,156,477 		JBrowse link
G Sms spermine synthase ISO protein:increased expression:pulmonary arterial smooth muscle cell RGD PMID:38261723 RGD:597621636 NCBI chr  X:41,331,693...41,387,713
Ensembl chr  X:41,331,799...41,387,712 		JBrowse link
G Sod2 superoxide dismutase 2 IEP
ISO 		protein:decreased expression:pulmonary artery
protein:decreased expression:small pulmonary artery 		RGD PMID:20529999 PMID:20529999 RGD:27095884, RGD:27095884 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sod3 superoxide dismutase 3 exacerbates IMP RGD PMID:21730301 RGD:14369425 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125 		JBrowse link
G Sod3m1Mcwi superoxide dismutase 3; mutation 1, Medical College of Wisconsin exacerbates IMP RGD PMID:21730301 RGD:14369425
G Sox17 SRY-box transcription factor 17 susceptibility
onset 		ISO associated with congenital heart disease;DNA:mutations:multiple (human)
ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: SOX17-related pulmonary arterial hypertension
DNA:SNPs:enhancers: (rs10103692, rs13266183) (human)
DNA:frameshift mutations, missense mutations, SNP:CDS, intron:multiple (human)
DNA:nonsense mutation:CDS:p.Q127* (human)
protein:decreased expression:lung endothelium (human) 		ClinVar
RGD		 PMID:25741868 PMID:28492532 PMID:30029678 PMID:30527955 PMID:29650961 More... RGD:329853313, RGD:329955464, RGD:329853735, RGD:329853326, RGD:329853317 NCBI chr 5:19,814,345...19,819,859
Ensembl chr 5:19,814,360...19,819,854 		JBrowse link
G Spats2l spermatogenesis associated, serine-rich 2-like ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:59,319,949...59,493,864
Ensembl chr 9:66,814,228...66,988,578 		JBrowse link
G Stradb STE20 related adaptor beta ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:60,414,182...60,433,084
Ensembl chr 9:67,908,309...67,927,222 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:68,572,911...68,602,890 		JBrowse link
G Tbx4 T-box transcription factor 4 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary arterial hypertension associated with congenital heart disease ClinVar PMID:15106123 PMID:16199547 PMID:23592887 PMID:25741868 PMID:28492532 More... NCBI chr10:70,730,686...70,760,829
Ensembl chr10:71,197,727...71,258,218 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO mRNA:increased expression:lung RGD PMID:25593290 RGD:38500244 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260 		JBrowse link
G Tmem237 transmembrane protein 237 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:60,533,348...60,569,253
Ensembl chr 9:68,030,664...68,063,525 		JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A IEP mRNA:increased expression:right ventricle RGD PMID:23325387 RGD:596933101 NCBI chr10:13,211,670...13,213,666
Ensembl chr10:13,211,673...13,213,704 		JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25741868 NCBI chr 8:112,766,791...112,815,203
Ensembl chr 8:112,766,508...112,810,540 		JBrowse link
G Trak2 trafficking kinesin protein 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:67,842,680...67,909,786
Ensembl chr 9:67,842,683...67,908,158 		JBrowse link
G Trpc4 transient receptor potential cation channel, subfamily C, member 4 ameliorates IMP RGD PMID:24113457 RGD:150429956 NCBI chr 2:138,307,676...138,476,856
Ensembl chr 2:140,458,296...140,626,969 		JBrowse link
G Trpc4Tn(sb)Tngen transient receptor potential cation channel, subfamily C, member 4; sleeping beauty induced mutant, Tngen ameliorates IMP RGD PMID:24113457 RGD:150429956
G Twist1 twist family bHLH transcription factor 1 ISO mRNA, protein:increased expression: pulmonary artery,lung: RGD PMID:25593290 RGD:38500244 NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:56,398,061...56,404,965 		JBrowse link
G Vim vimentin ISO protein:increased phosphorylation:lung RGD PMID:25593290 RGD:38500244 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
G Wdr12 WD repeat domain 12 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chr 9:68,969,547...68,996,811
Ensembl chr 9:68,969,547...68,996,811 		JBrowse link
Pulmonary Arterial Hypertension, Hereditary Hemorrhagic Telangiectasia-Related term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 ISO ClinVar Annotator: match by term: PULMONARY ARTERIAL HYPERTENSION, HEREDITARY HEMORRHAGIC TELANGIECTASIA-RELATED ClinVar PMID:8640225 PMID:9245985 PMID:10187774 PMID:10767348 PMID:11062473 More... NCBI chr 7:134,117,917...134,135,306
Ensembl chr 7:134,118,024...134,135,305 		JBrowse link
G Eng endoglin ISO ClinVar Annotator: match by term: PULMONARY ARTERIAL HYPERTENSION, HEREDITARY HEMORRHAGIC TELANGIECTASIA-RELATED ClinVar PMID:14684682 PMID:15024723 PMID:15115879 PMID:15687131 PMID:15879500 More... NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:36,326,202...36,370,933 		JBrowse link
Pulmonary Edema of Mountaineers term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnm1l dynamin 1-like IEP mRNA:increased expression:lung (rat) RGD PMID:23517027 RGD:12738217 NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420 		JBrowse link
G Fis1 fission, mitochondrial 1 IEP mRNA:increased expression:lung (rat) RGD PMID:23517027 RGD:12738217 NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25373139 NCBI chr 2:169,716,684...169,780,360
Ensembl chr 2:169,716,709...169,779,737 		JBrowse link
G Hmox1 heme oxygenase 1 IEP protein:increased expression:lung RGD PMID:21296072 RGD:10755745 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Mfn2 mitofusin 2 IEP mRNA:decreased expression:lung (rat) RGD PMID:23517027 RGD:12738217 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495 		JBrowse link
Pulmonary Hypertension, Chronic Thromboembolic, without Deep Vein Thrombosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-Hb-ps1 RT1 class II, locus Hb, pseudogene 1 susceptibility ISO DNA:polymorphisms:cds:HLA-DPB1*0202 (human) RGD PMID:19165231 RGD:5143999 NCBI chr20:4,775,598...4,779,590
Ensembl chr20:4,776,547...4,781,574 		JBrowse link
Pulmonary Hypertension, Hypoxia-Induced term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor treatment IMP RGD PMID:33836606 RGD:401940192 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP mRNA:increased expression:lung (rat) RGD PMID:33836606 RGD:401940192 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Egfr epidermal growth factor receptor treatment IMP RGD PMID:31264901 RGD:38599217 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 IEP RGD PMID:16761101 RGD:11252085 NCBI chr19:69,765,276...69,804,681 JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 IEP RGD PMID:16761101 RGD:11252085 NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:77,385,549...77,411,015 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase treatment IMP RGD PMID:25063801 RGD:10449119 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 IEP mRNA:decreased expression:lung (rat) RGD PMID:19823174 RGD:4145499 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 IEP mRNA:decreased expression:lung (rat) RGD PMID:19823174 RGD:4145499 NCBI chr19:9,180,428...9,206,113
Ensembl chr19:9,180,431...9,206,111 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase IEP mRNA, protein:increased expression:lung RGD PMID:24657469 RGD:11667099 NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831 		JBrowse link
G Il6 interleukin 6 ameliorates IMP RGD PMID:38602915 RGD:407450417 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Il6em1Yona interleukin 6; CRISPR/Cas9 induced mutant 1, Yona ameliorates IMP RGD PMID:38602915 RGD:407450417
G Mfn2 mitofusin 2 IEP mRNA, protein:decreased expression:lung (rat) RGD PMID:26485208 RGD:12910856 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495 		JBrowse link
G Nog noggin IEP mRNA,protein:decreased expression:lung: RGD PMID:25740156 RGD:12801489 NCBI chr10:74,625,874...74,627,501
Ensembl chr10:74,625,875...74,628,103 		JBrowse link
G Nos3 nitric oxide synthase 3 IEP mRNA,protein:increased expression:pulmonary artery RGD PMID:9950873 RGD:11533933 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Pcna proliferating cell nuclear antigen IEP protein:increased expression:lung (rat) RGD PMID:26485208 RGD:12910856 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Ptgis prostaglandin I2 synthase treatment IEP RGD PMID:12062720 RGD:401959327 NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650 		JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D IEP mRNA, protein:decreased expression:pulmonary artery (rat) RGD PMID:35848503 RGD:401976433 NCBI chr 5:95,093,221...97,415,498
Ensembl chr 5:95,095,858...96,178,903 		JBrowse link
G Slc39a12 solute carrier family 39 member 12 severity IMP RGD PMID:26258299 PMID:26258299 RGD:10401832, RGD:10401832 NCBI chr17:77,353,761...77,440,384
Ensembl chr17:82,262,351...82,349,229 		JBrowse link
G Slc39a12em77Tja solute carrier family 39 (zinc transporter), member 12; zinc finger nuclease induced mutant 77, Timothy J. Aitman severity IMP RGD PMID:26258299 PMID:26258299 RGD:10401832, RGD:10401832
G Sox17 SRY-box transcription factor 17 exacerbates ISO protein:decreased expression:pulmonary artery endothelium (mouse) RGD PMID:37066790 PMID:36919784 PMID:36205124 PMID:36913491 RGD:329853316, RGD:329853737, RGD:329853734, RGD:329853317 NCBI chr 5:19,814,345...19,819,859
Ensembl chr 5:19,814,360...19,819,854 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 IDA protein:increased phosphorylation:lung RGD PMID:38602915 RGD:407450417 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
pulmonary venoocclusive disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 IEP protein:increased expression:lung RGD PMID:32209028 RGD:38549370 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 9:68,685,942...68,801,353
Ensembl chr 9:68,685,988...68,801,350 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 ISO
IEP 		protein:increased expression:lung, endothelial cell RGD PMID:32209028 PMID:32209028 RGD:38549370, RGD:38549370 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 IEP protein:increased expression:lung RGD PMID:32209028 RGD:38549370 NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:21,952,631...21,977,116 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 IEP protein:increased expression:lung RGD PMID:32209028 RGD:38549370 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 disease_progression ISO
IEP 		protein:decreased expression:lung
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:24292273 PMID:32209028 PMID:32209028 RGD:38549370, RGD:38549370 NCBI chr 3:125,810,207...125,895,574
Ensembl chr 3:125,810,060...125,895,574 		JBrowse link
G Erg ETS transcription factor ERG IEP
ISO 		protein:decreased expression:lung RGD PMID:32209028 PMID:32209028 RGD:38549370, RGD:38549370 NCBI chr11:34,678,614...34,900,951
Ensembl chr11:48,148,153...48,370,688 		JBrowse link
G Hmox1 heme oxygenase 1 ISO
IEP 		protein:increased expression:lung, endothelial cell RGD PMID:32209028 PMID:32209028 RGD:38549370, RGD:38549370 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 IDA RGD PMID:32209028 RGD:38549370 NCBI chr 6:31,483,129...31,519,061
Ensembl chr 6:31,483,140...31,519,061 		JBrowse link
pulmonary venoocclusive disease 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr2 bone morphogenetic protein receptor type 2 ISO ClinVar Annotator: match by term: Pulmonary venoocclusive disease 1 OMIM
ClinVar		 PMID:3291115 PMID:10903931 PMID:11115378 PMID:12045205 PMID:12446270 More... NCBI chr 9:68,685,942...68,801,353
Ensembl chr 9:68,685,988...68,801,350 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO ClinVar Annotator: match by term: Pulmonary venoocclusive disease 1 ClinVar PMID:24033266 NCBI chr 3:125,810,207...125,895,574
Ensembl chr 3:125,810,060...125,895,574 		JBrowse link
pulmonary venoocclusive disease 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr2 bone morphogenetic protein receptor type 2 ISO ClinVar Annotator: match by term: Familial pulmonary capillary hemangiomatosis ClinVar PMID:18626305 PMID:24292273 NCBI chr 9:68,685,942...68,801,353
Ensembl chr 9:68,685,988...68,801,350 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO ClinVar Annotator: match by term: EIF2AK4-related condition | ClinVar Annotator: match by term: Familial pulmonary capillary hemangiomatosis OMIM
ClinVar		 PMID:12215525 PMID:24033266 PMID:24135949 PMID:24292273 PMID:24310610 More... NCBI chr 3:125,810,207...125,895,574
Ensembl chr 3:125,810,060...125,895,574 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      respiratory system disease 5247
        lower respiratory tract disease 2352
          lung disease 2314
            pulmonary hypertension 423
              Dursun Syndrome 1
              Familial Cirrhosis with Pulmonary Hypertension 0
              HUPRA Syndrome 2
              Pulmonary Arterial Hypertension + 107
              Pulmonary Edema of Mountaineers 5
              Pulmonary Hypertension, Chronic Thromboembolic, without Deep Vein Thrombosis 1
              Pulmonary Hypertension, Hypoxia-Induced 30
              Rowley-Rosenberg Syndrome 0
              Vater-Like Defects with Pulmonary Hypertension, Laryngeal Webs, and Growth Deficiency 0
              persistent fetal circulation syndrome 41
              primary pulmonary hypertension + 86
              pulmonary venoocclusive disease + 9
Path 2
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      cardiovascular system disease 5558
        vascular disease 4039
          artery disease 2864
            hypertension 1632
              pulmonary hypertension 423
                Dursun Syndrome 1
                Familial Cirrhosis with Pulmonary Hypertension 0
                HUPRA Syndrome 2
                Pulmonary Arterial Hypertension + 107
                Pulmonary Edema of Mountaineers 5
                Pulmonary Hypertension, Chronic Thromboembolic, without Deep Vein Thrombosis 1
                Pulmonary Hypertension, Hypoxia-Induced 30
                Rowley-Rosenberg Syndrome 0
                Vater-Like Defects with Pulmonary Hypertension, Laryngeal Webs, and Growth Deficiency 0
                persistent fetal circulation syndrome 41
                primary pulmonary hypertension + 86
                pulmonary venoocclusive disease + 9
paths to the root