RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: encephalomyelitis
Accession: DOID:640
browse the term
Definition: A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.
Synonyms: exact_synonym: encephalitis &/or myelitis; inflammatory encephalomyelitis; myeloencephalitides; myeloencephalitis
primary_id: MESH:D004679
xref: EFO:0001423 ; NCI:C34580
For additional species annotation, visit the
Alliance of Genome Resources .
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B2m
beta-2 microglobulin
ISO
associated with Theilovirus infection associated with Measles; protein:increased expression:cerebrospinal fluid
RGD
PMID:22335434 PMID:1402029
RGD:6482701 , RGD:6482707
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
ISO
protein:decreased expression:spinal cord
RGD
PMID:18466224
RGD:6483347
NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
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Ikzf4
IKAROS family zinc finger 4
ISS
MouseDO
NCBI chr 7:1,063,283...1,102,940
Ensembl chr 7:1,056,890...1,084,341
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Mir155
microRNA 155
severity
ISO
associated with viral infectious disease
RGD
PMID:27604627
RGD:21079465
NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
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Spp1
secreted phosphoprotein 1
IDA
RGD
PMID:11721059
RGD:1581329
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Tnf
tumor necrosis factor
ISO
RGD
PMID:9736027
RGD:12904033
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Ifng
interferon gamma
disease_progression
ISO
protein:increased expression:T cell:
RGD
PMID:11063842
RGD:8157598
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Nefl
neurofilament light chain
disease_progression
ISO
protein:increased expresssion:serum (human)
RGD
PMID:31383792
RGD:127284875
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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RT1-Bb
RT1 class II, locus Bb
susceptibility
ISO
DNA:polymorphism (human) DNA:polymorphism, haplotype: :
RGD
PMID:19722042 PMID:22786832
RGD:5147662 , RGD:36049763
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
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RT1-Db1
RT1 class II, locus Db1
susceptibility
ISO
DNA:polymorphisms (human) DNA:polymorphism, haplotype: :
RGD
PMID:19722042 PMID:22786832
RGD:5147662 , RGD:36049763
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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Mag
myelin-associated glycoprotein
IEP
protein:decreased expression:optic nerve
RGD
PMID:9820787
RGD:9685300
NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656
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Zc3h12a
zinc finger CCCH type containing 12A
disease_progression
ISO
RGD
PMID:26320658
RGD:11534569
NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351
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Ccl24
C-C motif chemokine ligand 24
ISO
protein:increased expression:plasma:
RGD
PMID:26615570
RGD:11538286
NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893
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Cd28
Cd28 molecule
ISO
RGD
PMID:18801465
RGD:5131614
NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
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Cx3cl1
C-X3-C motif chemokine ligand 1
ISO
protein:decreased expression:plasma:
RGD
PMID:26615570
RGD:11538286
NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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Cxcl9
C-X-C motif chemokine ligand 9
ISO
protein:decreased expression:plasma:
RGD
PMID:26615570
RGD:11538286
NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
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Disc1
DISC1 scaffold protein
susceptibility
ISO
DNA:SNP:Cds:p.S704C(human)
RGD
PMID:20227423
RGD:5509831
NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778
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Il16
interleukin 16
ISO
protein:decreased expression:plasma:
RGD
PMID:26615570
RGD:11538286
NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
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Prf1
perforin 1
ISO
RGD
PMID:21619669
RGD:6482801
NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
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Ren
renin
ISO
associated with Postural Orthostatic Tachycardia Syndrome; protein:increased activity:plasma (human)
RGD
PMID:21906029
RGD:6892702
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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RT1-Ba
RT1 class II, locus Ba
susceptibility
ISO
DNA:polymorphism (human) DNA:polymorphism: :HLA-DQA1*01 (human)
RGD
PMID:16049290 PMID:16049290
RGD:5147827 , RGD:5147827
NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
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Serpinf1
serpin family F member 1
ISO
protein:increased expression:cerebrospinal fluid (human)
RGD
PMID:16321154
RGD:28867246
NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
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Slc6a4
solute carrier family 6 member 4
severity
ISO
DNA:repeats:promoter: protein:decreased expression:rostral anterior cingulate cortex (human) DNA:repeats, haplotype:promoter:
RGD
PMID:14592408 PMID:15570154 PMID:26473596
RGD:36947383 , RGD:38500210 , RGD:11098915
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Trpc6
transient receptor potential cation channel, subfamily C, member 6
ISO
DNA:SNPs: :
RGD
PMID:27834303
RGD:40886272
NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
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Vegfa
vascular endothelial growth factor A
ISO
protein:decreased expression:plasma:
RGD
PMID:26615570
RGD:11538286
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Ccl2
C-C motif chemokine ligand 2
IEP
mRNA:increased expression:spinal cord (rat)
RGD
PMID:12098510
RGD:8655962
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Nefh
neurofilament heavy chain
ISO
protein:decreased expression:spinal cord:
RGD
PMID:12742652
RGD:27226817
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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Plp1
proteolipid protein 1
ISO
human sequence peptide in a mouse model; associated with Herpesviridae infections
RGD
PMID:12811845
RGD:30296670
NCBI chr X:100,184,039...100,201,035
Ensembl chr X:100,185,767...100,201,032
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Serpine1
serpin family E member 1
ISO
RGD
PMID:17983428
RGD:13208507
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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A2m
alpha-2-macroglobulin
treatment
IDA
RGD
PMID:1710603
RGD:10046021
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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Adam17
ADAM metallopeptidase domain 17
IEP
RGD
PMID:15878627
RGD:1559178
NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
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Adam8
ADAM metallopeptidase domain 8
ISO
RGD
PMID:9670863
RGD:2325244
NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801
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Aif1
allograft inflammatory factor 1
IEP
protein:altered expression:spinal cord (rat)
RGD
PMID:19246105
RGD:2313022
NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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Akap12
A-kinase anchoring protein 12
IEP
mRNA,protein:increased expression:spinal cord
RGD
PMID:20155814
RGD:14348972
NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886
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Alox15
arachidonate 15-lipoxygenase
ISO
RGD
PMID:15328042
RGD:5509618
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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Amigo2
adhesion molecule with Ig like domain 2
severity
ISO
RGD
PMID:28119027
RGD:14392778
NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695
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Anxa1
annexin A1
IEP
protein:increased expression:brain, astrocyte, macrophage
RGD
PMID:9472682
RGD:2306942
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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Apoe
apolipoprotein E
IEP
RGD
PMID:28578430
RGD:13703134
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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Aqp4
aquaporin 4
disease_progression severity
ISO IEP
RGD
PMID:21056916 PMID:19660138 PMID:21157915 PMID:23707078
RGD:5148015 , RGD:5490116 , RGD:5490117 , RGD:8696030
NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
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B2m
beta-2 microglobulin
ISO
RGD
PMID:15837577
RGD:6482690
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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B4galt6
beta-1,4-galactosyltransferase 6
ISO
mRNA:increased expression:astrocyte
RGD
PMID:25216636
RGD:14390079
NCBI chr18:11,958,382...12,015,247
Ensembl chr18:11,958,390...12,015,247
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Bdnf
brain-derived neurotrophic factor
IEP
RGD
PMID:23212569
RGD:10059360
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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C3
complement C3
IEP
protein:increased expression:cerebrospinal fluid
RGD
PMID:22320401
RGD:7175513
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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C6
complement C6
severity
IAGP
RGD
PMID:11970970
RGD:625607
NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275
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Cacna1b
calcium voltage-gated channel subunit alpha1 B
IEP
RGD
PMID:11353727
RGD:1580151
NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091
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Calca
calcitonin-related polypeptide alpha
no_association
ISO
RGD
PMID:19563774
RGD:5684360
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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Casp3
caspase 3
IEP
protein:increased activity, increased expression:spinal cord
RGD
PMID:18521931
RGD:2311436
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
IEP
protein:increased activity, increased expression:spinal cord
RGD
PMID:18521931
RGD:2311436
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
IEP
protein:increased expression:spinal cord
RGD
PMID:18521931
RGD:2311436
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cav3
caveolin 3
onset
IEP
Protein:increased expression:spinal cord, astrocyte
RGD
PMID:15925413
RGD:1582168
NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
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Cblb
Cbl proto-oncogene B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20453840
NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839
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Ccl1
C-C motif chemokine ligand 1
IEP
mRNA:decreased expression:lymph node
RGD
PMID:19865101
RGD:4145472
NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
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Ccl11
C-C motif chemokine ligand 11
IEP
mRNA:increased expression:lymph node
RGD
PMID:19865101
RGD:4145472
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
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Ccl2
C-C motif chemokine ligand 2
IEP
mRNA:increased expression:spinal cord mRNA:decreased expression:lymph node mRNA:increased expression:optic chiasma (rat)
RGD
PMID:17666800 PMID:19865101 PMID:11241588
RGD:2307114 , RGD:4145472 , RGD:8548888
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl3
C-C motif chemokine ligand 3
IEP
mRNA:increased expression:spinal cord
RGD
PMID:17666800
RGD:2307114
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Ccl5
C-C motif chemokine ligand 5
ISO IEP
protein:increased expression:brain (mouse) mRNA:increased expression:spinal cord
RGD
PMID:15833367 PMID:17666800
RGD:4890027 , RGD:2307114
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Ccr1
C-C motif chemokine receptor 1
IEP IMP
RGD
PMID:14655765 PMID:14512166
RGD:5688165 , RGD:5688167
NCBI chr 8:123,556,286...123,561,841
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Ccr2
C-C motif chemokine receptor 2
IEP
mRNA:increased expression:spinal cord
RGD
PMID:9655467
RGD:632391
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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Ccr3
C-C motif chemokine receptor 3
ISO
RGD
PMID:15034073
RGD:6893394
NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
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Ccr5
C-C motif chemokine receptor 5
IEP
mRNA:increased expression:spinal cord, macrophage, microglia (rat)
RGD
PMID:17484785
RGD:4890436
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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Cd28
Cd28 molecule
IMP
RGD
PMID:16061730
RGD:2307203
NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
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Cd4
Cd4 molecule
treatment
IEP IMP
protein:decreased expression:T lymphocyte:
RGD
PMID:9138014 PMID:3097071
RGD:10058963 , RGD:10058968
NCBI chr 4:157,668,878...157,695,366
Ensembl chr 4:157,668,878...157,695,191
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Cd80
Cd80 molecule
IMP
RGD
PMID:9379015
RGD:6902906
NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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Cd86
CD86 molecule
resistance disease_progression
ISO IEP
protein:increased expression:spinal cord, blood vessel (rat)
RGD
PMID:10477557 PMID:20451260
RGD:4892227 , RGD:4892207
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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Ciita
class II, major histocompatibility complex, transactivator
IAGP
RGD
PMID:15821736
RGD:1358146
NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440
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Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
IDA
RGD
PMID:21107918 PMID:10650887 PMID:7541143
RGD:6483335 , RGD:6483351 , RGD:6483353
NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
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Comt
catechol-O-methyltransferase
treatment
ISO
RGD
PMID:25242632
RGD:13450949
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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Cpb2
carboxypeptidase B2
IEP
RGD
PMID:22768796
RGD:7243111
NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556
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Cspg4
chondroitin sulfate proteoglycan 4
ISO IEP
protein:increased expression:spinal cord
RGD
PMID:21679768 PMID:20162860
RGD:5686852 , RGD:5686863
NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010
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Ctla4
cytotoxic T-lymphocyte-associated protein 4
ISO
RGD
PMID:9379015
RGD:6902906
NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
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Ctsc
cathepsin C
IEP
RGD
PMID:843913
RGD:1599653
NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
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Ctss
cathepsin S
ISO
RGD
PMID:21439785
RGD:5686915
NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
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Cx3cl1
C-X3-C motif chemokine ligand 1
IEP
RGD
PMID:16053521
RGD:4891973
NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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Cx3cr1
C-X3-C motif chemokine receptor 1
IEP IMP
RGD
PMID:16053521 PMID:24706865
RGD:4891973 , RGD:9491767
NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014
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Cxcr2
C-X-C motif chemokine receptor 2
ISO
RGD
PMID:19616545
RGD:7257694
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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Cxcr3
C-X-C motif chemokine receptor 3
IMP
RGD
PMID:21038468
RGD:5135506
NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969
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Dab2
DAB adaptor protein 2
disease_progression
IEP
RGD
PMID:21890121
RGD:7243155
NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476
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Dlk1
delta like non-canonical Notch ligand 1
ISO
RGD
PMID:24676147
RGD:150520045
NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522
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Dll1
delta like canonical Notch ligand 1
ISO
RGD
PMID:17947672
RGD:6482235
NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179
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Dll4
delta like canonical Notch ligand 4
ameliorates
ISO
RGD
PMID:21813770
RGD:155663662
NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931
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Dusp10
dual specificity phosphatase 10
ISO
RGD
PMID:15306813
RGD:7775013
NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
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Entpd1
ectonucleoside triphosphate diphosphohydrolase 1
disease_progression
IEP
RGD
PMID:19524108
RGD:9685491
NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317
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Epo
erythropoietin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18382691
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Ern1
endoplasmic reticulum to nucleus signaling 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30661753
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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Esr2
estrogen receptor 2
ISO
RGD
PMID:21565615 PMID:21182085
RGD:5508732 , RGD:5508735
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Faslg
Fas ligand
treatment
ISO
RGD
PMID:10944459
RGD:12903984
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Fcgr2a
Fc gamma receptor 2A
ISO
RGD
PMID:12576552
RGD:5508383
NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
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Fgf2
fibroblast growth factor 2
IEP
mRNA:increased expression:spinal cord
RGD
PMID:8929896 PMID:9814819
RGD:8655647 , RGD:9831448
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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Flt1
Fms related receptor tyrosine kinase 1
treatment
ISO
RGD
PMID:18721816
RGD:10402153
NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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Foxo3
forkhead box O3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27742544
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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Ghrh
growth hormone releasing hormone
resistance
ISO
RGD
PMID:21846799
RGD:5687168
NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889
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Ghrl
ghrelin and obestatin prepropeptide
treatment
IDA
RGD
PMID:19620309
RGD:12905041
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
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Gjc2
gap junction protein, gamma 2
ISO
protein:decreased expression:white matter of spinal cord, gap junction (mouse)
RGD
PMID:22461072
RGD:13208593
NCBI chr10:43,962,642...43,971,358
Ensembl chr10:43,962,642...43,970,467
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Gli1
GLI family zinc finger 1
ISO
RGD
PMID:18991353
RGD:12801440
NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
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Glud1
glutamate dehydrogenase 1
ISO
mRNA, protein:decreased expression:spinal cord
RGD
PMID:9145307
RGD:6484657
NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957
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Gpx3
glutathione peroxidase 3
IEP
RGD
PMID:22320401
RGD:7175513
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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Havcr2
hepatitis A virus cellular receptor 2
ISO IEP
mRNA:increased expression:spinal cord:
RGD
PMID:11823861 PMID:15913792
RGD:9686086 , RGD:9686113
NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
ISO IMP
RGD
PMID:17085013 PMID:14691063
RGD:5508469 , RGD:5508476
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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Ifnb1
interferon beta 1
ameliorates exacerbates treatment
ISO IMP IDA
RGD
PMID:9578846 PMID:18997868 PMID:19380780 PMID:8955226
RGD:401854237 , RGD:5147399 , RGD:401854246 , RGD:401854247
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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Ifng
interferon gamma
disease_progression treatment
ISO
RGD
PMID:15661899 PMID:22896638
RGD:7987912 , RGD:10755692
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Igf1
insulin-like growth factor 1
treatment
ISO
human protein in a rat model
RGD
PMID:7541143
RGD:6483353
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Il10
interleukin 10
treatment
IDA
RGD
PMID:23872438
RGD:7364993
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il10ra
interleukin 10 receptor subunit alpha
IEP
RGD
PMID:12620647
RGD:2316323
NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061
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Il12a
interleukin 12A
ISO
RGD
PMID:12471147
RGD:724447
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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Il12b
interleukin 12B
IEP
mRNA, protein:increased expression:lymph node
RGD
PMID:19233473
RGD:4831840
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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Il13
interleukin 13
severity
ISO
RGD
PMID:18250480 PMID:7523520
RGD:5684366 , RGD:5684367
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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Il16
interleukin 16
IMP
RGD
PMID:17641011
RGD:5024940
NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
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Il17a
interleukin 17A
treatment
IEP ISO IDA
mRNA, protein:increased expression:lymph node
RGD
PMID:19233473 PMID:16785554 PMID:20003332 PMID:16200068
RGD:4831840 , RGD:4889113 , RGD:4888522 , RGD:9212317
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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Il18
interleukin 18
IMP IEP
mRNA:increased expression:spinal cord
RGD
PMID:9834127 PMID:9846824
RGD:4889543 , RGD:4889542
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il18r1
interleukin 18 receptor 1
IEP
mRNA:increased expression:lymph node
RGD
PMID:19269041
RGD:2311529
NCBI chr 9:42,727,416...42,760,971
Ensembl chr 9:42,727,869...42,760,715
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Il1rn
interleukin 1 receptor antagonist
treatment
ISO
human protein in a rat model
RGD
PMID:7593560
RGD:8551836
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Il21
interleukin 21
IDA
RGD
PMID:18997868
RGD:5147399
NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996
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Il21r
interleukin 21 receptor
no_association disease_progression
ISO
RGD
PMID:18546146 PMID:18353312
RGD:6892939 , RGD:6892940
NCBI chr 1:180,168,028...180,195,690
Ensembl chr 1:180,168,097...180,195,522
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Il22
interleukin 22
IEP
RGD
PMID:19269041
RGD:2311529
NCBI chr 7:53,801,206...53,805,673
Ensembl chr 7:53,801,206...53,806,186
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Il27
interleukin 27
ISO
protein:decreased expression:blood serum (mouse)
RGD
PMID:33403844
RGD:126790527
NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
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Il2ra
interleukin 2 receptor subunit alpha
IEP
RGD
PMID:19269041
RGD:2311529
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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Il4
interleukin 4
treatment
ISO IEP
RGD
PMID:18239607 PMID:1383385
RGD:7829778 , RGD:8142395
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il6
interleukin 6
IEP ISO
protein:increased expression:oligodendrocytes (rat)
RGD
PMID:9358769 PMID:23322593
RGD:2307412 , RGD:12791289
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Itga4
integrin subunit alpha 4
treatment susceptibility
IMP IDA
rat bone marrow cells in a mouse model
RGD
PMID:12626659 PMID:18722022
RGD:9698418 , RGD:9698436
NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
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Jag1
jagged canonical Notch ligand 1
ISO
RGD
PMID:17947672
RGD:6482235
NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209
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Jak2
Janus kinase 2
ISO
RGD
PMID:22066025
RGD:6483041
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Jak3
Janus kinase 3
treatment
IDA
RGD
PMID:25012120
RGD:11533939
NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
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Kdr
kinase insert domain receptor
ISO
RGD
PMID:19233483
RGD:5684404
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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Kit
KIT proto-oncogene receptor tyrosine kinase
ISO
RGD
PMID:25972476
RGD:12910744
NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
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Lrp1
LDL receptor related protein 1
ISO
protein:increased expression:cerebellum, spinal cord
RGD
PMID:19299462
RGD:13800552
NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
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Lta
lymphotoxin alpha
IEP
mRNA:increased expression:spinal cord mRNA:increased expression:brain
RGD
PMID:7593556 PMID:9184655
RGD:1625038 , RGD:4143220
NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
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Mapt
microtubule-associated protein tau
treatment
IDA
RGD
PMID:15494405
RGD:1358431
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Mbp
myelin basic protein
ISO
human sequence peptide in a rat model; associated with Herpesviridae infections CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:11501064 PMID:15159442 PMID:17884951 PMID:24070732 PMID:16285900 PMID:12811845 More...
RGD:7349334 , RGD:30296670
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
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Mdk
midkine
IEP
RGD
PMID:9814819
RGD:9831448
NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130
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Mir146a
microRNA 146a
ISO
mRNA:increased expression:spinal cord (mouse)
RGD
PMID:22660635
RGD:155663483
NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
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Mir23b
microRNA 23b
treatment
ISO
mRNA:decreased expression:spinal cord (mouse)
RGD
PMID:22660635 PMID:22660635
RGD:155663483 , RGD:155663483
NCBI chr17:1,813,667...1,813,763
Ensembl chr17:1,813,667...1,813,763
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Mmp2
matrix metallopeptidase 2
IDA
RGD
PMID:19922364
RGD:2325703
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp7
matrix metallopeptidase 7
IEP
RGD
PMID:9549496
RGD:8547909
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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Mmp9
matrix metallopeptidase 9
treatment
IEP ISO
protein:increased expression:multiple tissues
RGD
PMID:9549496 PMID:24797785 PMID:20810258 PMID:22800566
RGD:8547909 , RGD:13204801 , RGD:13204762 , RGD:8547936
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mobp
myelin-associated oligodendrocyte basic protein
ISO
RGD
PMID:10623862
RGD:27226694
NCBI chr 8:119,869,504...119,899,605
Ensembl chr 8:119,869,626...119,899,563
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Mog
myelin oligodendrocyte glycoprotein
IDA ISO IEP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12904460 PMID:16931536 PMID:17654737 PMID:17728465 PMID:18566399 PMID:18667803 PMID:21068375 PMID:21317386 PMID:21341682 PMID:23360710 PMID:23547115 PMID:23639249 PMID:30661753 PMID:10384097 PMID:14624757 PMID:14624757 PMID:12799014 More...
RGD:9685372 , RGD:9685375 , RGD:9685375 , RGD:9685373
NCBI chr20:1,513,137...1,523,473
Ensembl chr20:1,513,239...1,523,474
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Mt1
metallothionein 1
ISO
mRNA:increased expression:brain (mouse)
RGD
PMID:19619133
RGD:6484112
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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Mt2A
metallothionein 2A
ISO
mRNA:increased expression:brain (mouse)
RGD
PMID:19619133
RGD:6484112
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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Mt3
metallothionein 3
ISO
mRNA:increased expression:brain (mouse)
RGD
PMID:19619133
RGD:6484112
NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
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Ncam1
neural cell adhesion molecule 1
IEP
protein:decreased expression:hippocampus
RGD
PMID:17064783
RGD:40924670
NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
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Nefl
neurofilament light chain
IEP
protein:increased expression:cerebrospinal fluid, spinal cord
RGD
PMID:16182933
RGD:2299007
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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Nfe2l2
NFE2 like bZIP transcription factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19910389
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Ngf
nerve growth factor
IEP
protein, mRNA:increased expression:thalamus and cortex, CNS
RGD
PMID:8866783
RGD:5508386
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Ngfr
nerve growth factor receptor
severity
ISO IEP
mRNA:increased expression:central nervous system
RGD
PMID:16519950 PMID:8866783
RGD:5508312 , RGD:5508386
NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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Nos2
nitric oxide synthase 2
ISO
RGD
PMID:21857957
RGD:5509069
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nr1h2
nuclear receptor subfamily 1, group H, member 2
ISO
RGD
PMID:21266776
RGD:6480877
NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
ISO
RGD
PMID:17322387
RGD:4892331
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Ntrk1
neurotrophic receptor tyrosine kinase 1
IEP
mRNA:increased expression:brain subventricular zone:
RGD
PMID:15589512
RGD:5684777
NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
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Olig1
oligodendrocyte transcription factor 1
treatment
ISO
RGD
PMID:24941845
RGD:40902822
NCBI chr11:30,514,379...30,516,521
Ensembl chr11:30,514,379...30,516,521
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Olig2
oligodendrocyte transcription factor 2
treatment
ISO IEP
RGD
PMID:24941845 PMID:29682587
RGD:40902822 , RGD:40902863
NCBI chr11:30,475,510...30,478,886
Ensembl chr11:30,475,398...30,480,152
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Pdcd1
programmed cell death 1
susceptibility
ISO
RGD
PMID:24648472
RGD:40818258
NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937
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Pdgfb
platelet derived growth factor subunit B
treatment
IDA
RGD
PMID:16042218
RGD:11080975
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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Pdgfra
platelet derived growth factor receptor alpha
treatment
IDA
RGD
PMID:16042218
RGD:11080975
NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
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Pdgfrb
platelet derived growth factor receptor beta
treatment
IDA
RGD
PMID:16042218
RGD:11080975
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
ISO
RGD
PMID:20303183
RGD:6482686
NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
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Plp1
proteolipid protein 1
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21068375 PMID:24941845
RGD:40902822
NCBI chr X:100,184,039...100,201,035
Ensembl chr X:100,185,767...100,201,032
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Ppara
peroxisome proliferator activated receptor alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17261635
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Prf1
perforin 1
ISO
RGD
PMID:20708278
RGD:6482806
NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
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Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
severity
ISO
RGD
PMID:19486896
RGD:6484540
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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Ptgs1
prostaglandin-endoperoxide synthase 1
ISO IEP
protein:increased expression:cerebral cortex, cerebellum, spinal cord protein:increased expression:microglia, macrophage,
RGD
PMID:21667309 PMID:10229132
RGD:5688149 , RGD:5688250
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO IEP
protein:increased expression:cerebral cortex, cerebellum, spinal cord protein:increased expression:endothelial cell
RGD
PMID:21667309 PMID:10229132
RGD:5688149 , RGD:5688250
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Ptn
pleiotrophin
IEP
mRNA:increased expression:spinal cord (rat)
RGD
PMID:9814819
RGD:9831448
NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456
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Qki
QKI, KH domain containing RNA binding
IEP
RGD
PMID:22740327
RGD:10045997
NCBI chr 1:50,387,716...50,501,568
Ensembl chr 1:50,387,698...50,498,831
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Rangrf
RAN guanine nucleotide release factor
IDA
RGD
PMID:8557821
RGD:6771380
NCBI chr10:53,677,467...53,678,880
Ensembl chr10:53,677,467...53,678,840
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Rhoa
ras homolog family member A
severity
IEP
protein:increased expression:microglial cell, brain
RGD
PMID:17983427
RGD:2298887
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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RT1-Ba
RT1 class II, locus Ba
IMP IDA
RGD
PMID:18050272 PMID:9834080 PMID:16723470
RGD:5147622 , RGD:5147666 , RGD:5147639
NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
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RT1-Bb
RT1 class II, locus Bb
IMP IDA ISO
RGD
PMID:16723470 PMID:9834080 PMID:16194572
RGD:5147639 , RGD:5147666 , RGD:5147647
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
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RT1-Da
RT1 class II, locus Da
ISO
RGD
PMID:8676084
RGD:5490166
NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
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RT1-Db1
RT1 class II, locus Db1
ISO
RGD
PMID:16194572
RGD:5147647
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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Serpine1
serpin family E member 1
ISO
mRNA,protein:increased expression,increased activity:spinal cord, astrocyte:
RGD
PMID:11733372
RGD:13208549
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Shh
sonic hedgehog signaling molecule
IEP ISO
RGD
PMID:15892298 PMID:18991353
RGD:12801423 , RGD:12801440
NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
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Sigmar1
sigma non-opioid intracellular receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30661753
NCBI chr 5:56,904,155...56,907,012
Ensembl chr 5:56,904,159...56,907,017
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Sirt1
sirtuin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:23547115
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Slpi
secretory leukocyte peptidase inhibitor
treatment
IDA
RGD
PMID:22436018
RGD:9999395
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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Sncb
synuclein, beta
IDA
RGD
PMID:12496452
RGD:730073
NCBI chr17:9,846,802...9,855,013
Ensembl chr17:9,846,802...9,855,012
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Srsf9
serine and arginine rich splicing factor 9
treatment
ISO
RGD
PMID:20616573
RGD:11040805
NCBI chr12:41,278,225...41,284,502
Ensembl chr12:41,275,687...41,284,499
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Stat1
signal transducer and activator of transcription 1
ISO
RGD
PMID:22066025
RGD:6483041
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Stat3
signal transducer and activator of transcription 3
ISO
RGD
PMID:22066025 PMID:17878325
RGD:6483041 , RGD:6892946
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Stat4
signal transducer and activator of transcription 4
IEP
RGD
PMID:11240014
RGD:7207888
NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540
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Tgfb1
transforming growth factor, beta 1
IEP
mRNA, protein:increased expression:central nervous system
RGD
PMID:17204936
RGD:2302088
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tgfb2
transforming growth factor, beta 2
IEP
mRNA, protein:decreased expression:central nervous system
RGD
PMID:17204936
RGD:2302088
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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Timp3
TIMP metallopeptidase inhibitor 3
IEP
protein:increased expression:spinal cord
RGD
PMID:15878627
RGD:1559178
NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
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Tlr2
toll-like receptor 2
IEP
protein:increased expression:spinal cord
RGD
PMID:18644848
RGD:2312575
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4
toll-like receptor 4
IEP
protein:increased expression:spinal cord
RGD
PMID:18644848
RGD:2312575
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tnf
tumor necrosis factor
treatment
IEP
RGD
PMID:11421579
RGD:12904661
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Vcam1
vascular cell adhesion molecule 1
IDA
RGD
PMID:12196270
RGD:1580348
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Vdr
vitamin D receptor
treatment
ISO
RGD
PMID:21318047 PMID:21287548
RGD:8158064 , RGD:13210791
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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Vegfa
vascular endothelial growth factor A
IDA ISO IEP
mRNA:decreased expression:Cerebrospinal Fluid: mRNA,protein:decreased expression:spinal cord:
RGD
PMID:12387457 PMID:17083617 PMID:17083617
RGD:634258 , RGD:7421596 , RGD:7421596
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Vip
vasoactive intestinal peptide
ISO
RGD
PMID:20978211
RGD:5685386
NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
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Xbp1
X-box binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30661753
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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