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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:pneumonia
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Accession:DOID:552 term browser browse the term
Definition:A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing. (DO)
Synonyms:exact_synonym: Experimental Lung Inflammation;   Lobar Pneumonia;   Lobar Pneumonias;   Lung Inflammation;   Lung Inflammations;   Pneumonias;   Pneumonitides;   Pneumonitis;   Pulmonary Inflammation;   acute pneumonia;   experimental lung inflammations;   pulmonary inflammations
 related_synonym: INCREASED SUSCEPTIBILITY TO PNEUMONIA
 primary_id: MESH:D011014
 xref: EFO:0003106;   EFO:1001991;   NCI:C3333
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCF1 ATP binding cassette subfamily F member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr 7:23,126,255...23,144,030
Ensembl chr 7:23,126,283...23,143,994 		JBrowse link
G ABO ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase severity ISO DNA:polymorphism:cds:allele A (human) RGD PMID:4375858 RGD:39938844 NCBI chr 1:272,912,239...272,935,316 JBrowse link
G ACE angiotensin I converting enzyme disease_progression ISO associated with Hypertension RGD PMID:17727310 PMID:19455553 PMID:20051911 RGD:4140916 RGD:4140918 RGD:4140922 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703 		JBrowse link
G ADORA1 adenosine A1 receptor ISO RGD PMID:15630442 RGD:5129098 NCBI chr 9:113,835,279...113,875,899
Ensembl chr 9:113,835,921...113,872,365 		JBrowse link
G ADORA2A adenosine A2a receptor ISO associated with Anemia, Sickle Cell
associated with Lung Injury		 RGD PMID:17601796 PMID:18703794 PMID:20798237 RGD:4890358 RGD:4890364 RGD:4890376 NCBI chr14:49,467,186...49,485,845
Ensembl chr14:49,468,877...49,485,850 		JBrowse link
G ADRB2 adrenoceptor beta 2 ISO RGD PMID:19925785 RGD:4145041 NCBI chr 2:150,032,649...150,035,591
Ensembl chr 2:150,033,579...150,040,731 		JBrowse link
G AGT angiotensinogen ISO CTD Direct Evidence: therapeutic CTD PMID:28960804 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G AHR aryl hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:23337360 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943 		JBrowse link
G ALB albumin disease_progression ISO RGD PMID:23286966 RGD:11035283 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696 		JBrowse link
G BDKRB2 bradykinin receptor B2 ISO RGD PMID:15021973 RGD:4891030 NCBI chr 7:117,438,622...117,472,005
Ensembl chr 7:117,438,713...117,472,005 		JBrowse link
G C3 complement C3 ISO RGD PMID:10886251 RGD:5129562 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228 		JBrowse link
G C3AR1 complement C3a receptor 1 ISO associated with Respiratory Syncytial Virus Infections RGD PMID:17079327 RGD:5129688 NCBI chr 5:63,088,778...63,098,750
Ensembl chr 5:63,088,778...63,098,750 		JBrowse link
G C5 complement C5 ISO associated with Respiratory Syncytial Virus Infections RGD PMID:3631740 PMID:17079327 RGD:5129688 RGD:5130161 NCBI chr 1:260,995,662...261,088,868
Ensembl chr 1:260,995,668...261,133,483 		JBrowse link
G CASP1 caspase 1, apoptosis-related cysteine peptidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328 		JBrowse link
G CCL11 chemokine (C-C motif) ligand 11 ISO CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:lung, respiratory system fluid/secretion		 RGD
CTD		 PMID:10595930 PMID:11290805 PMID:21625544 RGD:4145445 RGD:4145450 NCBI chr12:40,779,906...40,782,862
Ensembl chr12:40,779,173...40,782,893 		JBrowse link
G CCL17 C-C motif chemokine ligand 17 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:lung		 CTD
RGD		 PMID:15993846 PMID:21625544 RGD:2306304 NCBI chr 6:19,345,929...19,372,972
Ensembl chr 6:19,345,941...19,348,926 		JBrowse link
G CCL19 C-C motif chemokine ligand 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr10:32,110,366...32,112,529
Ensembl chr10:32,110,065...32,112,734 		JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 ISO protein:increased expression:respiratory system fluid/secretion
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:19648283 PMID:21625544 RGD:4891461 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
G CCL20 C-C motif chemokine ligand 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr15:129,172,743...129,176,069 JBrowse link
G CCL22 C-C motif chemokine ligand 22 ISO mRNA:increased expression:lung RGD PMID:15993846 RGD:2306304 NCBI chr 6:19,296,726...19,301,506
Ensembl chr 6:19,296,637...19,302,737 		JBrowse link
G CCL24 C-C motif chemokine ligand 24 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr 3:10,347,397...10,361,500 JBrowse link
G CCL3L1 chemokine (C-C motif) ligand 3-like 1 ISO mRNA:increased expression:bronchoalveolar lavage (human) RGD PMID:32407669 RGD:30296672 NCBI chr12:39,491,999...39,493,345
Ensembl chr12:39,491,914...39,493,774 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:bronchoalveolar lavage (human)		 CTD
RGD		 PMID:21625544 PMID:32407669 RGD:30296672 NCBI chr12:39,479,190...39,480,511
Ensembl chr12:39,478,882...39,481,082 		JBrowse link
G CCL8 chemokine (C-C motif) ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr12:40,740,468...40,741,970
Ensembl chr12:40,740,023...40,742,022 		JBrowse link
G CCR1 C-C motif chemokine receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20870892 PMID:21625544 RGD:5688175 NCBI chr13:29,227,218...29,233,862
Ensembl chr13:29,227,222...29,233,960 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:14615370 PMID:17284325 PMID:21625544 RGD:4145068 RGD:8661704 NCBI chr13:29,368,735...29,374,564
Ensembl chr13:29,369,122...29,376,343 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO mRNA:increased expression:lung RGD PMID:19762220 RGD:4145622 NCBI chr13:29,251,950...29,286,470
Ensembl chr13:29,285,012...29,286,467 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO Idiopathic Pneumonia Syndrome; mRNA:increased expression:lung (mouse) RGD PMID:15546955 RGD:4892103 NCBI chr13:29,382,383...29,387,902
Ensembl chr13:29,383,303...29,387,895 		JBrowse link
G CCR6 C-C motif chemokine receptor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr 1:2,016,600...2,034,172
Ensembl chr 1:2,018,608...2,019,821 		JBrowse link
G CCR7 C-C motif chemokine receptor 7 ISO mRNA, protein:increased expression:lung RGD PMID:16394278 RGD:5130919 NCBI chr12:21,857,286...21,869,211
Ensembl chr12:21,857,286...21,872,475 		JBrowse link
G CCR9 C-C motif chemokine receptor 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr13:29,033,609...29,051,227
Ensembl chr13:29,033,570...29,054,598 		JBrowse link
G CD14 CD14 molecule ISO protein:increased expression:multiple RGD PMID:20302606 RGD:4144794 NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581 		JBrowse link
G CD163 CD163 molecule ISO associated with liver disease;protein:increased expression:blood serum (human) RGD PMID:26339412 RGD:11251207 NCBI chr 5:63,300,200...63,334,497
Ensembl chr 5:63,300,231...63,334,498 		JBrowse link
G CD40LG CD40 ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr  X:111,778,666...111,788,901
Ensembl chr  X:111,778,493...111,789,709 		JBrowse link
G COQ6 coenzyme Q6, monooxygenase ISO ClinVar Annotator: match by term: increased susceptibility to pneumonia ClinVar NCBI chr 7:97,258,617...97,270,927
Ensembl chr 7:97,258,653...97,271,093 		JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 ISO RGD PMID:16855006 RGD:5130933 NCBI chr18:42,251,755...42,296,457
Ensembl chr18:42,251,749...42,295,467 		JBrowse link
G CRP C-reactive protein, pentraxin-related severity
disease_progression		 ISO RGD PMID:21258955 PMID:21439658 RGD:5131283 RGD:5131291 NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,793,350...90,805,218 		JBrowse link
G CSF2 colony stimulating factor 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:11732872 PMID:19633061 RGD:4142837 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155 		JBrowse link
G CSF3R colony stimulating factor 3 receptor ISO mRNA:increased expression:bronchoalveolar lavage (human) RGD PMID:32407669 RGD:30296672 NCBI chr 6:92,550,159...92,565,798
Ensembl chr 6:92,550,161...92,565,477 		JBrowse link
G CSK C-terminal Src kinase ISO RGD PMID:14975240 RGD:5134363 NCBI chr 7:58,736,473...58,755,034
Ensembl chr 7:58,736,531...58,755,260 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr 6:19,312,351...19,324,439 JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO associated with Lupus Erythematosus, Systemic;mRNA:increased expression:lung RGD PMID:14979941 PMID:15265940 RGD:5135445 RGD:5135491 NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948 		JBrowse link
G CXCL2 chemokine (C-X-C motif) ligand 2 ISO mRNA:increased expression:lung
mRNA, protein:increased expression:lung		 RGD PMID:18367723 PMID:20728373 RGD:5134959 RGD:5135235 NCBI chr 8:70,157,253...70,159,145
Ensembl chr 8:70,157,214...70,159,138 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:bronchoalveolar lavage (human)		 CTD
RGD		 PMID:21625544 PMID:32407669 RGD:30296672 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:serum
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:15265940 PMID:17052299 PMID:21625544 RGD:5135440 RGD:5135445 NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,501...71,670,271 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr15:120,219,657...120,230,203 JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO CTD Direct Evidence: marker/mechanism
associated with Lupus Erythematosus, Systemic;mRNA:increased expression:lung		 CTD
RGD		 PMID:14979941 PMID:15265940 PMID:21625544 RGD:5135445 RGD:5135491 NCBI chr  X:57,592,032...57,595,706
Ensembl chr  X:57,592,038...57,595,692 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 susceptibility ISO DNA:polymorphism (human) RGD PMID:15928955 RGD:4142512 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO protein:increased expression:alveolus, epithelial cell
DNA:polymorphism (human)		 RGD PMID:14698565 PMID:15928955 RGD:4142512 RGD:4892223 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817 		JBrowse link
G DEFB1 defensin beta 1 ISO protein:increased expression:serum RGD PMID:17000097 RGD:4892262
G EDN1 endothelin 1 severity ISO protein:increased secretion:plasma (human) RGD PMID:20529344 RGD:4144879 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G EGF epidermal growth factor resistance ISO RGD PMID:21701422 RGD:6906904 NCBI chr 8:112,235,607...112,330,062
Ensembl chr 8:112,234,386...112,330,046 		JBrowse link
G EGR1 early growth response 1 ISO CTD Direct Evidence: therapeutic CTD PMID:29787794 NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296 		JBrowse link
G ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) ISO ClinVar Annotator: match by term: increased susceptibility to pneumonia ClinVar NCBI chr 7:97,270,698...97,316,578
Ensembl chr 7:97,266,824...97,306,981 		JBrowse link
G FCGR3A Fc fragment of IgG receptor IIIa treatment ISO associated with Hodgkin Disease;DNA:SNP:exon:p.F158V (rs396991) (human) RGD PMID:20423913 RGD:11352258 NCBI chr 4:88,948,357...88,956,513 JBrowse link
G GRP gastrin releasing peptide ISO protein:increased expression:serum (human) RGD PMID:30146822 RGD:401700396 NCBI chr 1:161,708,815...161,721,986
Ensembl chr 1:161,708,812...161,721,782 		JBrowse link
G HDC histidine decarboxylase ISO RGD PMID:14556983 RGD:5143922 NCBI chr 1:121,505,677...121,525,416
Ensembl chr 1:121,505,751...121,525,252 		JBrowse link
G HMOX1 heme oxygenase 1 susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:allele:promoter:L allele of the (GT)n repeat (>30 repeats)		 CTD
RGD		 PMID:16582079 RGD:1601608
G ICAM1 intercellular adhesion molecule 1 treatment ISO associated with Reperfusion Injury RGD PMID:22882462 RGD:8547727 NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205 		JBrowse link
G IFNAR1 interferon alpha and beta receptor subunit 1 resistance ISO Cryptococcus (yeast) pneumonia RGD PMID:18566423 RGD:5490275 NCBI chr13:196,925,731...196,951,398
Ensembl chr13:196,925,734...196,952,239 		JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:20080200 PMID:31095431 RGD:7495767 NCBI chr17:11,289,607...11,348,557
Ensembl chr17:11,289,690...11,348,549 		JBrowse link
G IL10 interleukin 10 disease_progression ISO protein:increased expression:blood RGD PMID:20595152 RGD:4140400 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G IL13 interleukin 13 ISO associated with Respiratory Distress Syndrome, Newborn; protein:increased expression:bronchoalveolar lavage fluid
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:19695190 PMID:21625544 RGD:4145774 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093 		JBrowse link
G IL13RA2 interleukin 13 receptor subunit alpha 2 ISO mRNA:increased expression:lung, fibroblast RGD PMID:15161635 RGD:4890021 NCBI chr  X:94,402,665...94,455,609
Ensembl chr  X:94,402,676...94,439,060 		JBrowse link
G IL17A interleukin 17A ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20498020 PMID:21625544 PMID:22848348 RGD:4888524 RGD:9068417 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153 		JBrowse link
G IL18 interleukin 18 ISO CTD Direct Evidence: marker/mechanism
associated with reperfusion injury
mRNA, protein:increased expression:lung,bronchoalveolar fluid
protein:increased expression:serum		 CTD
RGD		 PMID:11739527 PMID:15955140 PMID:16052682 PMID:17400729 PMID:21625544 RGD:4889590 RGD:4889825 RGD:4889836 RGD:729357 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219 		JBrowse link
G IL1A interleukin 1 alpha ISO mRNA:increased expression:lung RGD PMID:8806881 RGD:7794765 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,121 		JBrowse link
G IL1R1 interleukin 1 receptor type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr 3:52,192,912...52,334,734
Ensembl chr 3:52,192,915...52,288,485 		JBrowse link
G IL1R2 interleukin 1 receptor type 2 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:bronchoalveolar lavage (human)		 CTD
RGD		 PMID:21625544 PMID:32407669 RGD:30296672 NCBI chr 3:52,367,434...52,406,393
Ensembl chr 3:52,367,437...52,406,334 		JBrowse link
G IL1RN interleukin 1 receptor antagonist no_association
disease_progression		 ISO mRNA:increased expression:bronchioalveolar lavage fluid, neutrophil (rat)
mRNA:increased expression:bronchoalveolar lavage (human)
DNA:polymorphism (human)
DNA:polymorphism:intron (human)
mRNA:increased expression:lung		 RGD PMID:1385928 PMID:16369129 PMID:17569781 PMID:18838927 PMID:19900796 More... RGD:30296672 RGD:4142865 RGD:4142871 RGD:4143204 RGD:4143213 RGD:8551846
G IL27 interleukin 27 ISO RGD PMID:19124731 RGD:5128483 NCBI chr 3:18,421,962...18,427,916
Ensembl chr 3:18,421,981...18,427,915 		JBrowse link
G IL2RB interleukin 2 receptor subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr 5:10,610,094...10,650,315
Ensembl chr 5:10,628,962...10,650,314 		JBrowse link
G IL33 interleukin 33 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24453940 NCBI chr 1:215,899,830...215,941,944
Ensembl chr 1:215,899,436...215,941,840 		JBrowse link
G IL4 interleukin 4 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:bronchoalveolar lavage (human)		 CTD
RGD		 PMID:21625544 PMID:32407669 RGD:30296672 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G IL4R interleukin 4 receptor ISO mRNA:decreased expression:bronchoalveolar lavage (human) RGD PMID:32407669 RGD:30296672 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544 		JBrowse link
G IL5RA interleukin 5 receptor subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr13:59,651,184...59,692,211
Ensembl chr13:59,652,271...59,690,176 		JBrowse link
G IL6 interleukin 6 disease_progression ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:blood		 CTD
RGD		 PMID:20595152 PMID:21625544 RGD:4140400 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr16:35,101,304...35,151,832
Ensembl chr16:35,101,306...35,192,220 		JBrowse link
G IRF5 interferon regulatory factor 5 severity ISO RGD PMID:29847542 RGD:40907064 NCBI chr18:19,678,377...19,691,154
Ensembl chr18:19,678,687...19,691,243 		JBrowse link
G ITGA2 integrin subunit alpha 2 treatment ISO RGD PMID:11207307 RGD:8693217 NCBI chr16:32,336,240...32,440,311
Ensembl chr16:32,336,292...32,437,103 		JBrowse link
G ITGA4 integrin subunit alpha 4 treatment ISO RGD PMID:8703473 RGD:9698424 NCBI chr15:86,942,054...87,028,428
Ensembl chr15:86,947,240...87,030,364 		JBrowse link
G ITGB2 integrin subunit beta 2 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:10030843 PMID:21625544 RGD:6482228 NCBI chr13:207,514,281...207,544,108
Ensembl chr13:207,512,950...207,544,107 		JBrowse link
G ITGB3 integrin subunit beta 3 disease_progression ISO RGD PMID:12746502 RGD:5100478 NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,514...16,752,292 		JBrowse link
G LCN2 lipocalin 2 exacerbates ISO associated with Escherichia Coli Infections RGD PMID:20633248 RGD:126779583 NCBI chr 1:268,609,975...268,614,651
Ensembl chr 1:268,609,887...268,614,644 		JBrowse link
G LIAS lipoic acid synthetase ISO CTD Direct Evidence: therapeutic CTD PMID:32017981 NCBI chr 8:30,699,278...30,717,009
Ensembl chr 8:30,699,330...30,720,335 		JBrowse link
G LOC110258578 interleukin-1 beta-like ISO mRNA, protein:increased expression:lung
mRNA:increased expression:bronchoalveolar lavage (human)
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:lung		 RGD
CTD		 PMID:19825784 PMID:19901996 PMID:20007584 PMID:20155581 PMID:20476872 More... RGD:30296672 RGD:4142536 RGD:4142812 RGD:4142827 RGD:4142831 RGD:4143211
G MBL2 mannose binding lectin 2 ISO protein:increased secretion:lung (human)
protein:increased expression:Bronchoalveolar lavage:		 RGD PMID:15249448 PMID:18988662 RGD:4889459 RGD:8693755 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083 		JBrowse link
G MIF macrophage migration inhibitory factor severity ISO DNA:repeats:promoter RGD PMID:19346297 RGD:4891058 NCBI chr14:49,840,303...49,841,063
Ensembl chr14:49,840,305...49,841,068 		JBrowse link
G MIR150-1 microRNA mir-150-1 ISO CTD Direct Evidence: therapeutic CTD PMID:29205062 NCBI chr 6:54,580,912...54,580,988
Ensembl chr 6:54,580,912...54,580,988 		JBrowse link
G MIR20A microRNA mir-20a ISO RGD PMID:29115456 RGD:25823151 NCBI chr11:60,735,109...60,735,179
Ensembl chr11:60,735,099...60,735,196 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO RGD PMID:18007984 RGD:5130157 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788 		JBrowse link
G MUC1 mucin 1, cell surface associated ISO protein:increased expression:serum RGD PMID:11802251 RGD:5131281 NCBI chr 4:94,626,317...94,631,194 JBrowse link
G MUC2 mucin 2, oligomeric mucus/gel-forming treatment ISO RGD PMID:23590300 RGD:7349359 NCBI chr 2:689,363...719,542
Ensembl chr 2:689,364...710,330 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:26882889 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109 		JBrowse link
G MYLK myosin light chain kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15863634 NCBI chr13:136,509,878...136,809,674
Ensembl chr13:136,509,755...136,809,668 		JBrowse link
G NFKBIA NFKB inhibitor alpha susceptibility ISO associated with combined immunodeficiency;DNA:missense mutation:CDS:c.106T>G (p.S36A) (human) RGD PMID:31683054 RGD:126925985 NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277 		JBrowse link
G NRP1 neuropilin 1 treatment ISO RGD PMID:36373992 RGD:401901166 NCBI chr10:56,280,673...56,430,832
Ensembl chr10:56,280,665...56,430,777 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20561897 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196 		JBrowse link
G POMC proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:6254450 NCBI chr 3:113,661,712...113,668,558
Ensembl chr 3:113,661,004...113,670,418 		JBrowse link
G SERPINE1 serpin family E member 1 disease_progression ISO DNA:polymorphism:promoter:
Pneumonia, Ventilator-Associated; protein:increased expression:Bronchoalveolar Lavage Fluid		 RGD PMID:19387177 PMID:20473240 RGD:4143511 RGD:4143525 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547 		JBrowse link
G SFTPA1 surfactant protein A1 ISO protein:decreased expression:lung RGD PMID:8542113 PMID:15967375 RGD:4143394 RGD:4143452 NCBI chr14:82,091,178...82,095,393
Ensembl chr14:82,091,178...82,095,393 		JBrowse link
G SFTPB surfactant protein B ISO RGD PMID:12594064 PMID:15967375 PMID:16024721 RGD:4143393 RGD:4143394 RGD:4143412 NCBI chr 3:59,101,940...59,113,442
Ensembl chr 3:59,101,981...59,112,396 		JBrowse link
G SFTPC surfactant protein C ISO RGD PMID:15967375 RGD:4143394 NCBI chr14:6,440,309...6,443,104
Ensembl chr14:6,440,309...6,443,095 		JBrowse link
G SFTPD surfactant protein D ISO associated with Bronchitis;protein:decreased expression:lung RGD PMID:15967375 PMID:17925426 PMID:18266831 RGD:4143394 RGD:4143504 RGD:4143517 NCBI chr14:82,051,400...82,069,258
Ensembl chr14:82,051,451...82,067,976 		JBrowse link
G SIRT1 sirtuin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:24633890 NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,167...71,123,297 		JBrowse link
G SLC11A2 solute carrier family 11 member 2 ISO RGD PMID:21278260 RGD:5688709
G SOD3 superoxide dismutase 3 ISO RGD PMID:16842247 RGD:1581268 NCBI chr 8:18,796,633...18,802,156
Ensembl chr 8:18,796,637...18,802,152 		JBrowse link
G SPP1 secreted phosphoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340 		JBrowse link
G TGFB1 transforming growth factor beta 1 severity ISO protein:increased expression:lung
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:19181604 PMID:19965809 PMID:21625544 RGD:4145120 RGD:4145141 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046 		JBrowse link
G TLR2 toll like receptor 2 susceptibility ISO RGD PMID:19011150 RGD:4145330 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
G TLR4 toll like receptor 4 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:20357263 PMID:26882889 RGD:4142858 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TNC tenascin C ISO protein:increased expression:serum, respiratory system fluid/secretion RGD PMID:19721293 RGD:4889573 NCBI chr 1:255,533,235...255,630,381
Ensembl chr 1:255,533,238...255,630,376 		JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:21625544 PMID:28917655 PMID:34390737 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625544 NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,051...64,331,909 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B susceptibility ISO associated with Carcinoma, Non-Small-Cell Lung; DNA:snp:cds:p.M196R rs1061622 (human)
Idiopathic Pneumonia Syndrome
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:18664626 PMID:20811626 PMID:21625544 RGD:5131286 RGD:5131448 NCBI chr 6:72,195,420...72,231,146
Ensembl chr 6:72,195,435...72,231,147 		JBrowse link
G TNFSF12 TNF superfamily member 12 ISO mRNA:decreased expression:bronchoalveolar lavage (human) RGD PMID:32407669 RGD:30296672 NCBI chr12:52,843,026...52,853,328
Ensembl chr12:52,843,026...52,853,325 		JBrowse link
G VDR vitamin D receptor susceptibility ISO DNA:SNP: :rs2239185(human) RGD PMID:17224129 PMID:25367052 RGD:11074745 RGD:4889851 NCBI chr 5:78,205,807...78,266,505
Ensembl chr 5:78,205,810...78,266,475 		JBrowse link
aspiration pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO associated with Cerebrovascular Accident RGD PMID:14990394 RGD:4140926 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703 		JBrowse link
G CXCL2 chemokine (C-X-C motif) ligand 2 ISO RGD PMID:19515386 RGD:4891456 NCBI chr 8:70,157,253...70,159,145
Ensembl chr 8:70,157,214...70,159,138 		JBrowse link
G EDN1 endothelin 1 ISO protein:increased secretion:plasma (rat) RGD PMID:19262391 RGD:4145069 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G IL1A interleukin 1 alpha ISO protein:increased expression:Bronchoalveolar Lavage Fluid RGD PMID:18042282 RGD:4142854 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,121 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15607125 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:Bronchoalveolar Lavage Fluid RGD PMID:18042282 RGD:4142854 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415 		JBrowse link
bacterial pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 ISO RGD PMID:11238654 RGD:5128828 NCBI chr 3:28,360,868...28,472,940
Ensembl chr 3:28,360,873...28,473,456 		JBrowse link
G ACE2 angiotensin converting enzyme 2 ISO associated with Pseudomonas Infections;mRNA, protein:altered expression, altered activity:lung (mouse) RGD PMID:31645418 RGD:40818279 NCBI chr  X:12,099,849...12,152,204
Ensembl chr  X:12,093,242...12,151,286 		JBrowse link
G AGER advanced glycosylation end-product specific receptor severity ISO RGD PMID:21629785 RGD:6767559 NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,120...24,221,162 		JBrowse link
G AMCF-II alveolar macrophage-derived chemotactic factor-II ISO RGD PMID:19846873 RGD:4145490 NCBI chr 8:70,008,225...70,010,360
Ensembl chr 8:70,008,162...70,010,358 		JBrowse link
G C3 complement C3 ISO RGD PMID:16014897 RGD:5129508 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228 		JBrowse link
G C3AR1 complement C3a receptor 1 ISO RGD PMID:16461429 RGD:5129690 NCBI chr 5:63,088,778...63,098,750
Ensembl chr 5:63,088,778...63,098,750 		JBrowse link
G C5 complement C5 ISO RGD PMID:17975174 RGD:5129707 NCBI chr 1:260,995,662...261,088,868
Ensembl chr 1:260,995,668...261,133,483 		JBrowse link
G CAT catalase ISO protein:decreased expression:lung, plasma RGD PMID:19842849 RGD:5130748 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G CCL19 C-C motif chemokine ligand 19 ISO mRNA, protein:increased expression:lung RGD PMID:20176793 RGD:5130918 NCBI chr10:32,110,366...32,112,529
Ensembl chr10:32,110,065...32,112,734 		JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 ISO RGD PMID:20042590 RGD:4891443 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 ISO RGD PMID:20483921 RGD:5130905 NCBI chr12:39,479,190...39,480,511
Ensembl chr12:39,478,882...39,481,082 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:20042590 RGD:4891443 NCBI chr13:29,368,735...29,374,564
Ensembl chr13:29,369,122...29,376,343 		JBrowse link
G CCR7 C-C motif chemokine receptor 7 ISO RGD PMID:20176793 RGD:5130918 NCBI chr12:21,857,286...21,869,211
Ensembl chr12:21,857,286...21,872,475 		JBrowse link
G CD14 CD14 molecule ISO RGD PMID:16210672 RGD:4144197 NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581 		JBrowse link
G CD40 CD40 molecule ISO RGD PMID:20102413 RGD:5132268 NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528 		JBrowse link
G CD80 CD80 molecule ISO RGD PMID:20949109 RGD:4892562 NCBI chr13:140,693,312...140,730,541
Ensembl chr13:140,693,382...140,728,976 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex ISO RGD PMID:18643924 RGD:5133701 NCBI chr14:111,316,178...111,351,669
Ensembl chr14:111,315,141...111,351,868 		JBrowse link
G CSF3 colony stimulating factor 3 treatment
disease_progression		 ISO associated with Peritonitis; RGD PMID:12352049 PMID:21373266 RGD:11039437 RGD:5133733 NCBI chr12:22,333,445...22,335,949
Ensembl chr12:22,333,449...22,338,753 		JBrowse link
G CSF3R colony stimulating factor 3 receptor disease_progression ISO RGD PMID:17185469 RGD:5133739 NCBI chr 6:92,550,159...92,565,798
Ensembl chr 6:92,550,161...92,565,477 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 severity ISO RGD PMID:15618188 PMID:16299319 RGD:5135458 RGD:5135459 NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948 		JBrowse link
G CXCL11 C-X-C motif chemokine ligand 11 ISO RGD PMID:15618188 RGD:5135459 NCBI chr 8:71,713,790...71,725,669
Ensembl chr 8:71,713,803...71,725,674 		JBrowse link
G CXCL2 chemokine (C-X-C motif) ligand 2 severity ISO RGD PMID:11052817 PMID:19239431 PMID:21723409 RGD:5135062 RGD:5135065 RGD:5135234 NCBI chr 8:70,157,253...70,159,145
Ensembl chr 8:70,157,214...70,159,138 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ISO RGD PMID:15618188 RGD:5135459 NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,501...71,670,271 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO RGD PMID:15618188 RGD:5135459 NCBI chr  X:57,592,032...57,595,706
Ensembl chr  X:57,592,038...57,595,692 		JBrowse link
G DEFB1 defensin, beta 1 ISO protein:increased expression:plasma RGD PMID:10213993 RGD:4892266 NCBI chr15:38,076,057...38,077,899
Ensembl chr15:38,076,057...38,077,899 		JBrowse link
G F2 coagulation factor II, thrombin ISO protein:increased expression:lung RGD PMID:21897338 RGD:6893486 NCBI chr 2:15,793,257...15,819,151
Ensembl chr 2:15,791,455...15,819,137 		JBrowse link
G FOXP3 forkhead box P3 severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr  X:43,303,777...43,328,164
Ensembl chr  X:43,303,785...43,322,968 		JBrowse link
G GP1BA glycoprotein Ib platelet subunit alpha exacerbates ISO associated with Escherichia Coli Infections RGD PMID:27845343 RGD:42722624 NCBI chr12:51,975,810...51,979,428
Ensembl chr12:51,975,874...51,977,757 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO mRNA:decreased expression:polymorphonuclear leukocyte RGD PMID:24465168 RGD:126848796 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,439...5,227,758 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased expression:lung (mouse) RGD PMID:19846873 RGD:4145490 NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205 		JBrowse link
G IFNAR1 interferon alpha and beta receptor subunit 1 severity ISO RGD PMID:19487810 RGD:5490274 NCBI chr13:196,925,731...196,951,398
Ensembl chr13:196,925,734...196,952,239 		JBrowse link
G IFNG interferon gamma severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IL10 interleukin 10 severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G IL15 interleukin 15 ISO RGD PMID:17911627 RGD:5000754 NCBI chr 8:85,666,963...85,740,980
Ensembl chr 8:85,667,321...85,678,461 		JBrowse link
G IL17A interleukin 17A severity ISO RGD PMID:18802100 PMID:25398094 RGD:38501102 RGD:4889153 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153 		JBrowse link
G IL18 interleukin 18 ISO RGD PMID:17664259 RGD:4889913 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 treatment ISO associated with Sepsis
associated with Acinetobacter infectious disease		 RGD PMID:20959556 PMID:29508184 RGD:40818077 RGD:5144223 NCBI chr 3:51,868,549...51,902,454
Ensembl chr 3:51,846,792...51,951,383 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO RGD PMID:18322242 PMID:18596024 RGD:4143205 RGD:4143206
G IL6 interleukin 6 severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 ISO RGD PMID:20439918 PMID:28120642 RGD:34888234 RGD:36049799 NCBI chr 5:30,524,704...30,601,067
Ensembl chr 5:30,526,793...30,609,921 		JBrowse link
G IRF1 interferon regulatory factor 1 ISO RGD PMID:11854220 RGD:5128725 NCBI chr 2:134,776,122...134,783,646
Ensembl chr 2:134,776,129...134,783,801 		JBrowse link
G IRF3 interferon regulatory factor 3 ISO RGD PMID:20720199 RGD:4891951 NCBI chr 6:54,701,733...54,706,079
Ensembl chr 6:54,701,668...54,707,151 		JBrowse link
G ITGB3 integrin subunit beta 3 ISO protein:increased expression:lung, neutrophil RGD PMID:15114484 RGD:4993468 NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,514...16,752,292 		JBrowse link
G LEP leptin ISO RGD PMID:11937559 RGD:5128871 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,323 		JBrowse link
G LOC110258578 interleukin-1 beta-like severity
treatment		 ISO associated with Agranulocytosis RGD PMID:7546648 PMID:18596024 PMID:25398094 RGD:10755357 RGD:38501102 RGD:4143205
G LOC110261221 cytochrome P450 2J2-like ISO protein:decreased expression:lung RGD PMID:14766666 RGD:1625385 NCBI chr 6:152,321,816...152,358,179
Ensembl chr 6:152,321,848...152,648,979 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 severity ISO associated with Escherichia Coli Infections RGD PMID:22514650 RGD:150340681 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874 		JBrowse link
G MBL2 mannose binding lectin 2 ISO Legionella Pneumonia; DNA:mutations:5' utr, exon:multiple (human) RGD PMID:18641104 RGD:4889477 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083 		JBrowse link
G MC1R melanocortin 1 receptor ISO RGD PMID:18304533 RGD:5687324 NCBI chr 6:181,225...182,187
Ensembl chr 6:181,225...182,187 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO protein:increased expression:bronchoalveolar lavage fluid RGD PMID:17202364 PMID:19535150 RGD:5129533 RGD:5130727 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788 		JBrowse link
G MPO myeloperoxidase ISO protein:increased activity:bronchoalveolar lavage Fluid: RGD PMID:11269653 RGD:5130992 NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 ISO RGD PMID:19360122 RGD:5131449 NCBI chr18:42,464,667...42,509,135
Ensembl chr18:42,432,050...42,512,264 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO RGD PMID:19360122 RGD:5131449 NCBI chr 6:34,132,127...34,167,446
Ensembl chr 6:34,130,938...34,177,534 		JBrowse link
G PDPN podoplanin ISO protein:increased expression:lung RGD PMID:7864138 RGD:2292375 NCBI chr 6:73,019,063...73,050,000
Ensembl chr 6:73,019,057...73,049,996 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO protein:decreased expression:lung RGD PMID:12524254 RGD:724645 NCBI chr12:14,667,643...14,723,296
Ensembl chr12:14,649,044...14,723,293 		JBrowse link
G PGF placental growth factor ISO protein:increased expression:plasma RGD PMID:16702604 RGD:6483601 NCBI chr 7:98,149,510...98,162,784
Ensembl chr 7:98,148,994...98,162,741 		JBrowse link
G PTEN phosphatase and tensin homolog ameliorates ISO myeloid knockout RGD PMID:21527775 RGD:127285594 NCBI chr14:99,929,590...100,021,619 JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 ameliorates ISO RGD PMID:28387756 RGD:127229944 NCBI chr 7:74,951,145...74,955,255
Ensembl chr 7:74,951,145...74,955,251 		JBrowse link
G RORC RAR related orphan receptor C severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr 4:97,374,672...97,399,017
Ensembl chr 4:97,375,136...97,400,209 		JBrowse link
G SERPINE1 serpin family E member 1 severity ISO RGD PMID:17032919 RGD:4144840 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547 		JBrowse link
G SFTPA1 surfactant protein A1 ISO protein:increased expression:lung RGD PMID:12169586 RGD:4143464 NCBI chr14:82,091,178...82,095,393
Ensembl chr14:82,091,178...82,095,393 		JBrowse link
G SFTPB surfactant protein B ISO protein:increased expression:lung
associated with Cystic Fibrosis;protein:increased expression:lung		 RGD PMID:12169586 PMID:15271694 RGD:4143403 RGD:4143464 NCBI chr 3:59,101,940...59,113,442
Ensembl chr 3:59,101,981...59,112,396 		JBrowse link
G SFTPC surfactant protein C ISO RGD PMID:12169586 PMID:18566429 RGD:4143464 RGD:4144114 NCBI chr14:6,440,309...6,443,104
Ensembl chr14:6,440,309...6,443,095 		JBrowse link
G SFTPD surfactant protein D ISO protein:increased expression:lung
associated with Cystic Fibrosis;protein:decreased expression:lung		 RGD PMID:12169586 PMID:15271694 RGD:4143403 RGD:4143464 NCBI chr14:82,051,400...82,069,258
Ensembl chr14:82,051,451...82,067,976 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:18192501 RGD:6892945 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992 		JBrowse link
G TGFB1 transforming growth factor beta 1 severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:18768871 PMID:19844782 RGD:4145337 RGD:4889533 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:16210672 PMID:20650991 RGD:4144172 RGD:4144197 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TLR5 toll like receptor 5 ISO RGD PMID:19801452 RGD:5129503 NCBI chr10:19,387,666...19,410,024
Ensembl chr10:19,387,666...19,410,024 		JBrowse link
G TLR6 toll like receptor 6 ISO RGD PMID:19844782 RGD:4889533 NCBI chr 8:30,159,744...30,180,650
Ensembl chr 8:30,159,754...30,180,650 		JBrowse link
G TLR9 toll like receptor 9 ISO RGD PMID:20360853 RGD:5130719 NCBI chr13:34,353,444...34,370,990
Ensembl chr13:34,349,609...34,357,673 		JBrowse link
G TNF tumor necrosis factor treatment
severity
disease_progression		 ISO associated with Agranulocytosis RGD PMID:7546648 PMID:9310939 PMID:10650487 PMID:12958055 RGD:10449451 RGD:10450564 RGD:10755357 RGD:4143476 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO protein:increased expression:serum (mouse) RGD PMID:19842848 RGD:5131429 NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,051...64,331,909 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO protein:increased expression:serum (mouse) RGD PMID:19842848 RGD:5131429 NCBI chr 6:72,195,420...72,231,146
Ensembl chr 6:72,195,435...72,231,147 		JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 severity
ameliorates		 ISO RGD PMID:16960786 PMID:22996209 PMID:24465168 RGD:126848796 RGD:126925987 RGD:127229902 NCBI chr 7:36,510,253...36,531,796
Ensembl chr 7:36,510,253...36,531,796 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A ISO associated with Pseudomonas Infections RGD PMID:29695841 RGD:39938967 NCBI chr 6:93,541,334...93,551,200
Ensembl chr 6:93,541,334...93,551,193 		JBrowse link
bronchopneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL5 C-C motif chemokine ligand 5 ISO protein:increased secretion:serum (human) RGD PMID:20350425 RGD:4892019 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 disease_progression ISO associated with Plague RGD PMID:21356370 RGD:5134954 NCBI chr15:120,219,657...120,230,203 JBrowse link
G MBL2 mannose binding lectin 2 ISO associated with Down Syndrome; protein:decreased secretion:serum (human) RGD PMID:19804807 RGD:4889483 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083 		JBrowse link
Chlamydia pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD274 CD274 molecule ISO mRNA:increased expression:lung RGD PMID:26378990 RGD:41412180 NCBI chr 1:216,646,378...216,792,731
Ensembl chr 1:216,660,041...216,792,724 		JBrowse link
G PDCD1 programmed cell death 1 ISO mRNA:increased expression:lung RGD PMID:26378990 RGD:41412180 NCBI chr15:140,337,353...140,347,493
Ensembl chr15:140,336,258...140,347,478 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta severity ISO RGD PMID:29893841 RGD:40890270 NCBI chr 6:70,026,254...70,086,950
Ensembl chr 6:70,026,373...70,084,742 		JBrowse link
cryptogenic organizing pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFRSF1A TNF receptor superfamily member 1A ISO protein:increased expression:lung, macrophage (human) RGD PMID:21144722 RGD:5131112 NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,051...64,331,909 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO protein:increased expression:lung, lymphocyte (human) RGD PMID:21144722 RGD:5131112 NCBI chr 6:72,195,420...72,231,146
Ensembl chr 6:72,195,435...72,231,147 		JBrowse link
desquamative interstitial pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SFTPC surfactant protein C ISO OMIM:263000 MouseDO NCBI chr14:6,440,309...6,443,104
Ensembl chr14:6,440,309...6,443,095 		JBrowse link
idiopathic interstitial pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased expression:lung, alveolar macrophage (human) RGD PMID:19218648 RGD:4145518 NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205 		JBrowse link
G IL6 interleukin 6 ISO protein:increased expression:bronchoalveolar lavage (rat) RGD PMID:10988147 RGD:11062092 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 ISO protein:increased expression:hyperplastic lung epithelium, alveolus (human) RGD PMID:20718723 RGD:6893300 NCBI chr 2:69,280,940...69,290,267
Ensembl chr 2:69,276,336...69,294,382 		JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO RGD PMID:21444868 RGD:7245946 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888 		JBrowse link
G SCGB1A1 secretoglobin family 1A member 1 ISO protein:increased expression:serum RGD PMID:15467329 RGD:5144148 NCBI chr 2:9,297,282...9,302,204
Ensembl chr 2:9,297,283...9,302,165 		JBrowse link
G TERT telomerase reverse transcriptase ISO ClinVar Annotator: match by term: idiopathic fibrosing alveolitis ClinVar PMID:9536098 PMID:15814878 PMID:15885610 PMID:16247010 PMID:17460043 More... NCBI chr16:79,258,591...79,276,421
Ensembl chr16:79,258,591...79,276,421 		JBrowse link
Klebsiella pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 ISO RGD PMID:11207292 RGD:38549344 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G IL23A interleukin 23 subunit alpha severity ISO RGD PMID:16157683 RGD:39457940 NCBI chr 5:21,732,416...21,733,981
Ensembl chr 5:21,732,165...21,734,267 		JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 severity ISO mRNA:increased expression:lung (mouse) RGD PMID:20864681 PMID:22729155 RGD:35316077 RGD:36049798 NCBI chr 5:30,524,704...30,601,067
Ensembl chr 5:30,526,793...30,609,921 		JBrowse link
G LCN2 lipocalin 2 exacerbates
ameliorates		 ISO protein:increased expression:lung
protein:increased expression:serum		 RGD PMID:19342674 PMID:25234944 PMID:29633303 RGD:126725082 RGD:126725084 RGD:126725085 NCBI chr 1:268,609,975...268,614,651
Ensembl chr 1:268,609,887...268,614,644 		JBrowse link
G PLAC8 placenta associated 8 severity ISO RGD PMID:17404296 RGD:40924563 NCBI chr 8:135,250,761...135,279,091 JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 disease_progression ISO RGD PMID:24396044 RGD:126925976 NCBI chr 7:36,510,253...36,531,796
Ensembl chr 7:36,510,253...36,531,796 		JBrowse link
Legionnaires' disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase ISO protein:increased expression:serum RGD PMID:9255891 RGD:5128857 NCBI chr17:47,044,492...47,072,232
Ensembl chr17:47,044,497...47,072,245 		JBrowse link
G AMCF-II alveolar macrophage-derived chemotactic factor-II ISO mRNA, protein:increased expression:lung RGD PMID:11254553 RGD:5135252 NCBI chr 8:70,008,225...70,010,360
Ensembl chr 8:70,008,162...70,010,358 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:16113250 RGD:4891897 NCBI chr 6:19,312,351...19,324,439 JBrowse link
G CXCL2 chemokine (C-X-C motif) ligand 2 ISO mRNA, protein:increased expression:lung RGD PMID:11254553 RGD:5135252 NCBI chr 8:70,157,253...70,159,145
Ensembl chr 8:70,157,214...70,159,138 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO RGD PMID:11254553 RGD:5135252 NCBI chr15:120,219,657...120,230,203 JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: therapeutic CTD PMID:11349020 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IL18 interleukin 18 ISO RGD PMID:11083766 RGD:4889865 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219 		JBrowse link
G MBL2 mannose binding lectin 2 susceptibility ISO RGD PMID:19073229 RGD:12910934 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 ISO RGD PMID:20685341 RGD:5131443 NCBI chr18:42,464,667...42,509,135
Ensembl chr18:42,432,050...42,512,264 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO RGD PMID:20685341 RGD:5131443 NCBI chr 6:34,132,127...34,167,446
Ensembl chr 6:34,130,938...34,177,534 		JBrowse link
G TLR5 toll like receptor 5 ISO ClinVar Annotator: match by term: Legionnaire disease, susceptibility to ClinVar
OMIM		 PMID:14623910 PMID:16027372 PMID:23447684 NCBI chr10:19,387,666...19,410,024
Ensembl chr10:19,387,666...19,410,024 		JBrowse link
G TLR9 toll like receptor 9 ISO RGD PMID:18426877 RGD:5130707 NCBI chr13:34,353,444...34,370,990
Ensembl chr13:34,349,609...34,357,673 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO RGD PMID:18838275 RGD:5131445 NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,051...64,331,909 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO RGD PMID:18838275 RGD:5131445 NCBI chr 6:72,195,420...72,231,146
Ensembl chr 6:72,195,435...72,231,147 		JBrowse link
Mycoplasma pneumoniae pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase ISO protein:increased expression:serum RGD PMID:9255891 RGD:5128857 NCBI chr17:47,044,492...47,072,232
Ensembl chr17:47,044,497...47,072,245 		JBrowse link
G ATP1B2 ATPase Na+/K+ transporting subunit beta 2 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr12:52,925,697...52,932,638
Ensembl chr12:52,925,693...52,932,635 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 ISO RGD PMID:16988274 RGD:4892091 NCBI chr12:39,479,190...39,480,511
Ensembl chr12:39,478,882...39,481,082 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO protein:increased secretion:lung, secretion (mouse) RGD PMID:18717637 RGD:4891914 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118 		JBrowse link
G CCL8 chemokine (C-C motif) ligand 8 ISO RGD PMID:16988274 RGD:4892091 NCBI chr12:40,740,468...40,741,970
Ensembl chr12:40,740,023...40,742,022 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO protein:increased expression:lung, T-helper cell (mouse) RGD PMID:16988274 RGD:4892091 NCBI chr13:29,382,383...29,387,902
Ensembl chr13:29,383,303...29,387,895 		JBrowse link
G CLEC5A C-type lectin domain containing 5A severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr18:8,004,423...8,014,390
Ensembl chr18:8,004,448...8,016,308 		JBrowse link
G COL3A1 collagen type III alpha 1 chain severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr15:93,556,914...93,595,678
Ensembl chr15:93,526,603...93,596,363 		JBrowse link
G COL6A2 collagen type VI alpha 2 chain severity ISO RGD PMID:28302172 RGD:32716376
G CRP C-reactive protein, pentraxin-related ISO RGD PMID:21426633 RGD:5131292 NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,793,350...90,805,218 		JBrowse link
G DNASE1L3 deoxyribonuclease 1L3 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr13:39,958,384...39,976,114
Ensembl chr13:39,958,387...39,975,946 		JBrowse link
G FCER2 Fc epsilon receptor II severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 2:71,454,046...71,468,149
Ensembl chr 2:71,453,824...71,468,149 		JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr11:5,620,698...5,797,095
Ensembl chr11:5,621,212...5,795,264 		JBrowse link
G GALC galactosylceramidase ISO associated with Guillain-Barre syndrome; protein:increased expression:Cerebrospinal fluid, serum (human)
associated with Guillain-Barre syndrome; protein:increased expression:serum (human)
protein:increased expression:serum (mouse)		 RGD PMID:12225900 PMID:27490360 PMID:29301655 PMID:30396892 RGD:38599168 RGD:38599169 RGD:38599171 RGD:38599172 NCBI chr 7:109,894,576...109,961,407
Ensembl chr 7:109,894,578...109,961,413 		JBrowse link
G HDC histidine decarboxylase ISO RGD PMID:17158962 RGD:5143920 NCBI chr 1:121,505,677...121,525,416
Ensembl chr 1:121,505,751...121,525,252 		JBrowse link
G HTRA3 HtrA serine peptidase 3 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 8:2,794,780...2,819,686
Ensembl chr 8:2,793,799...2,820,184 		JBrowse link
G IFNG interferon gamma ISO mRNA:increased expression:lung: RGD PMID:7935058 RGD:10755754 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IL13 interleukin 13 ISO protein:increased expression:serum RGD PMID:20416219 RGD:4145765 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093 		JBrowse link
G IL22RA2 interleukin 22 receptor subunit alpha 2 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 1:27,073,481...27,090,635
Ensembl chr 1:27,073,610...27,091,236 		JBrowse link
G INHBA inhibin subunit beta A severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr12:53,115,379...53,117,128
NCBI chr18:52,889,684...52,909,260
Ensembl chr18:52,889,684...52,900,967 		JBrowse link
G KLRF1 killer cell lectin like receptor F1 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 5:62,032,559...62,044,856
Ensembl chr 5:62,032,574...62,043,988 		JBrowse link
G LOC100623720 collagen alpha-1(VI) chain severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr13:208,295,245...208,321,789
Ensembl chr13:208,295,451...208,313,127 		JBrowse link
G MS4A1 membrane spanning 4-domains A1 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 2:11,216,238...11,229,060
Ensembl chr 2:11,215,901...11,222,914 		JBrowse link
G PLD4 phospholipase D family member 4 severity ISO RGD PMID:28302172 RGD:32716376
G SPIB Spi-B transcription factor severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 6:55,272,847...55,280,881
Ensembl chr 6:55,272,890...55,280,874 		JBrowse link
G TCF7 transcription factor 7 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 2:136,422,740...136,456,323
Ensembl chr 2:136,422,940...136,457,910 		JBrowse link
G TCL1A TCL1 family AKT coactivator A severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 7:116,933,785...116,939,353
Ensembl chr 7:116,934,948...116,939,320 		JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:serum RGD PMID:20416219 RGD:4145765 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415 		JBrowse link
G TNFRSF13C TNF receptor superfamily member 13C severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 5:6,699,812...6,703,403
Ensembl chr 5:6,699,878...6,703,656 		JBrowse link
pleuropneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase ISO RGD PMID:12773506 RGD:4890419 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,019...90,907,090 		JBrowse link
Pneumococcal Pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase ISO RGD PMID:26456931 RGD:11098923 NCBI chr 5:62,777,236...62,787,342
Ensembl chr 5:62,777,352...62,787,369 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO RGD PMID:20231413 RGD:4890435 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,019...90,907,090 		JBrowse link
G BTK Bruton tyrosine kinase ameliorates ISO RGD PMID:30646846 RGD:124715470 NCBI chr  X:82,981,512...83,014,475
Ensembl chr  X:82,981,515...83,014,573 		JBrowse link
G C3 complement C3 disease_progression ISO protein:decreased expression:serum
associated with Liver Cirrhosis, Experimental;protein:decreased expression:respiratory system fluid/secretion		 RGD PMID:20405 PMID:15972516 PMID:17956621 RGD:5129509 RGD:5129523 RGD:5130163 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228 		JBrowse link
G C5 complement C5 severity ISO RGD PMID:7814608 RGD:5130159 NCBI chr 1:260,995,662...261,088,868
Ensembl chr 1:260,995,668...261,133,483 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 susceptibility ISO RGD PMID:16455992 RGD:4892130 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118 		JBrowse link
G CD14 CD14 molecule ISO RGD PMID:17185649 RGD:4144788 NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581 		JBrowse link
G CHI3L1 chitinase 3 like 1 ISO protein:increased secretion:serum (human) RGD PMID:10515841 RGD:4892626 NCBI chr 9:113,885,541...113,895,033
Ensembl chr 9:113,885,542...113,895,131 		JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 ISO RGD PMID:21774994 RGD:5147472 NCBI chr12:17,251,361...17,306,308
Ensembl chr12:17,252,020...17,306,285 		JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 ISO RGD PMID:21774994 RGD:5147472 NCBI chr18:42,251,755...42,296,457
Ensembl chr18:42,251,749...42,295,467 		JBrowse link
G CRP C-reactive protein, pentraxin-related disease_progression ISO RGD PMID:21281676 RGD:5131293 NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,793,350...90,805,218 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:lung RGD PMID:20381636 RGD:5135285 NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,501...71,670,271 		JBrowse link
G DEFB1 defensin, beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr15:38,076,057...38,077,899
Ensembl chr15:38,076,057...38,077,899 		JBrowse link
G HMOX1 heme oxygenase 1 ISO associated with influenza;protein:increased expression:lung RGD PMID:17348295 RGD:4145366
G HP haptoglobin ISO RGD PMID:19396720 RGD:5147385 NCBI chr 6:14,980,382...14,985,245 JBrowse link
G IL15 interleukin 15 ISO protein:increased expression:alveolar macrophage, bronchial epithelial cell RGD PMID:17611121 RGD:5000755 NCBI chr 8:85,666,963...85,740,980
Ensembl chr 8:85,667,321...85,678,461 		JBrowse link
G IL15RA interleukin 15 receptor subunit alpha ISO RGD PMID:17611121 RGD:5000755 NCBI chr10:65,022,227...65,054,385 JBrowse link
G IL17A interleukin 17A ISO RGD PMID:19995896 RGD:4888531 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153 		JBrowse link
G IL18 interleukin 18 ISO RGD PMID:15770015 RGD:4889960 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219 		JBrowse link
G IL6 interleukin 6 ISO RGD PMID:20643849 RGD:4143255 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G LEP leptin ISO RGD PMID:17822444 RGD:5128869 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,323 		JBrowse link
G LEPR leptin receptor ISO RGD PMID:21148797 RGD:5128846 NCBI chr 6:146,802,297...146,896,152
Ensembl chr 6:146,801,954...146,895,995 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
G MASP2 MBL associated serine protease 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12904520 NCBI chr 6:71,224,637...71,243,041
Ensembl chr 6:71,224,637...71,243,874 		JBrowse link
G MBL2 mannose binding lectin 2 no_association ISO DNA:mutations:5' utr, exon:multiple (human)
DNA:polymorphisms:5' utr, exon:multiple (human)		 RGD PMID:12047967 PMID:18641104 RGD:4889477 RGD:4889478 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO RGD PMID:17056580 RGD:4891950 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G PTEN phosphatase and tensin homolog ameliorates ISO myeloid knockout RGD PMID:20505137 RGD:127285597 NCBI chr14:99,929,590...100,021,619 JBrowse link
G SFTPD surfactant protein D severity ISO RGD PMID:16255775 RGD:4143519 NCBI chr14:82,051,400...82,069,258
Ensembl chr14:82,051,451...82,067,976 		JBrowse link
G SIRT1 sirtuin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,167...71,123,297 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 ISO RGD PMID:29263110 RGD:39128230 NCBI chr 2:141,359,402...141,367,222
Ensembl chr 2:141,358,993...141,367,198 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:19956717 RGD:4145321 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
G TNF tumor necrosis factor ISO associated with influenza;protein:increased expression:lung RGD PMID:9032201 PMID:17348295 RGD:4143479 RGD:4145366 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415 		JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 ameliorates ISO RGD PMID:19596984 PMID:24752755 RGD:126928121 RGD:127229903 NCBI chr 7:36,510,253...36,531,796
Ensembl chr 7:36,510,253...36,531,796 		JBrowse link
pneumocystosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AZIN1 antizyme inhibitor 1 ISO mRNA:increased expression:alveolar macrophage RGD PMID:19158080 RGD:14700806 NCBI chr 4:34,221,368...34,257,261
Ensembl chr 4:34,234,679...34,257,134 		JBrowse link
G C3 complement C3 ISO RGD PMID:17169032 RGD:5129525 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228 		JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:20618689 RGD:4891428 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
G CD40 CD40 molecule treatment ISO RGD PMID:10968950 RGD:8547797 NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528 		JBrowse link
G CSF2 colony stimulating factor 2 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:19487471 RGD:5131475 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155 		JBrowse link
G IL23A interleukin 23 subunit alpha ISO RGD PMID:17403873 RGD:39458043 NCBI chr 5:21,732,416...21,733,981
Ensembl chr 5:21,732,165...21,734,267 		JBrowse link
G IL33 interleukin 33 treatment ISO RGD PMID:21220696 RGD:40400892 NCBI chr 1:215,899,830...215,941,944
Ensembl chr 1:215,899,436...215,941,840 		JBrowse link
G MUC1 mucin 1, cell surface associated ISO protein:increased expression:serum RGD PMID:9617869 RGD:5131424 NCBI chr 4:94,626,317...94,631,194 JBrowse link
G NOS2 nitric oxide synthase 2 ISO mRNA:increased expression:alveolar macrophage
protein:decreased dimerization:alveolar macrophage		 RGD PMID:20377877 PMID:20558778 RGD:4144112 RGD:4891486 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G SFTPA1 surfactant protein A1 ISO protein:increased expression:lung RGD PMID:11385364 RGD:4143431 NCBI chr14:82,091,178...82,095,393
Ensembl chr14:82,091,178...82,095,393 		JBrowse link
G SFTPB surfactant protein B ISO protein:decreased expression:lung RGD PMID:11385364 RGD:4143431 NCBI chr 3:59,101,940...59,113,442
Ensembl chr 3:59,101,981...59,112,396 		JBrowse link
G SFTPC surfactant protein C ISO protein:decreased expression:lung RGD PMID:11385364 RGD:4143431 NCBI chr14:6,440,309...6,443,104
Ensembl chr14:6,440,309...6,443,095 		JBrowse link
G SFTPD surfactant protein D ISO protein:increased expression:lung RGD PMID:11385364 RGD:4143431 NCBI chr14:82,051,400...82,069,258
Ensembl chr14:82,051,451...82,067,976 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:18400546 RGD:4145341 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
Pneumonia, Ventilator-Associated term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GC GC vitamin D binding protein ISO protein:increased expression:bronchoalveolar fluid: RGD PMID:21136918 RGD:5509873 NCBI chr 8:68,326,293...68,360,262
Ensembl chr 8:68,326,299...68,360,262 		JBrowse link
Staphylococcal Pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 treatment ISO RGD PMID:23613163 RGD:38676477
G CD86 CD86 molecule ISO protein:decreased expression:spleen, plasmacytoid dendritic cell (mouse) RGD PMID:20949109 RGD:4892562 NCBI chr13:138,427,573...138,504,307
Ensembl chr13:138,427,533...138,504,310 		JBrowse link
G CFTR CF transmembrane conductance regulator ISO RGD PMID:28289144 RGD:36049750 NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950 		JBrowse link
G CSF3 colony stimulating factor 3 treatment ISO RGD PMID:10228098 RGD:11039478 NCBI chr12:22,333,445...22,335,949
Ensembl chr12:22,333,449...22,338,753 		JBrowse link
G FN1 fibronectin 1 ISO RGD PMID:12065530 RGD:7205474 NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,043 		JBrowse link
G IFNAR1 interferon alpha and beta receptor subunit 1 susceptibility ISO RGD PMID:19603548 RGD:5490273 NCBI chr13:196,925,731...196,951,398
Ensembl chr13:196,925,734...196,952,239 		JBrowse link
G IL10 interleukin 10 ISO mRNA, protein:increased expression:lung RGD PMID:22940620 RGD:7364825 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G IL15 interleukin 15 ISO RGD PMID:18390740 RGD:4996474 NCBI chr 8:85,666,963...85,740,980
Ensembl chr 8:85,667,321...85,678,461 		JBrowse link
G IL33 interleukin 33 ISO mRNA:increased expression:lung: RGD PMID:28401938 RGD:40400699 NCBI chr 1:215,899,830...215,941,944
Ensembl chr 1:215,899,436...215,941,840 		JBrowse link
G LOC110258578 interleukin-1 beta-like ISO RGD PMID:20065029 RGD:4142828
G NOD2 nucleotide binding oligomerization domain containing 2 ISO RGD PMID:20493961 RGD:5131444 NCBI chr 6:34,132,127...34,167,446
Ensembl chr 6:34,130,938...34,177,534 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISO protein:increased expression:lung (mouse) RGD PMID:28663335 RGD:13432209 NCBI chr 1:5,698,508...6,731,132
Ensembl chr 1:5,465,312...6,730,872 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 severity ISO mRNA:increased expression:lung
associated with influenza		 RGD PMID:31782850 RGD:39131288 NCBI chr14:39,202,165...39,292,041
Ensembl chr14:39,202,169...39,292,003 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 treatment ISO RGD PMID:25445964 RGD:127229910 NCBI chr 7:74,951,145...74,955,255
Ensembl chr 7:74,951,145...74,955,251 		JBrowse link
G SFTPB surfactant protein B ameliorates ISO RGD PMID:20007532 RGD:151667448 NCBI chr 3:59,101,940...59,113,442
Ensembl chr 3:59,101,981...59,112,396 		JBrowse link
Streptococcus pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase exacerbates ISO RGD PMID:27421701 RGD:126779562 NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,657...36,759,552 		JBrowse link
G BTK Bruton tyrosine kinase ISO RGD PMID:30873567 RGD:124715473 NCBI chr  X:82,981,512...83,014,475
Ensembl chr  X:82,981,515...83,014,573 		JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 ISO mRNA:increased expression:lung (mouse) RGD PMID:20385761 RGD:39938865 NCBI chr17:9,245,283...9,260,140
Ensembl chr17:9,245,196...9,260,473 		JBrowse link
G IFNG interferon gamma ISO protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IL6 interleukin 6 ISO protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 severity ISO RGD PMID:22492852 RGD:35316076 NCBI chr 5:30,524,704...30,601,067
Ensembl chr 5:30,526,793...30,609,921 		JBrowse link
G ITGB2 integrin subunit beta 2 susceptibility ISO RGD PMID:11390487 RGD:127345090 NCBI chr13:207,514,281...207,544,108
Ensembl chr13:207,512,950...207,544,107 		JBrowse link
G LAMP1 lysosomal associated membrane protein 1 ISO protein:increased expression:lung, natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chr11:78,600,818...78,617,587
Ensembl chr11:78,600,645...78,617,616 		JBrowse link
G MARCO macrophage receptor with collagenous structure exacerbates ISO RGD PMID:15263032 RGD:41412189 NCBI chr15:24,502,935...24,541,286
Ensembl chr15:24,503,108...24,541,283 		JBrowse link
G NCR1 natural cytotoxicity triggering receptor 1 severity ISO RGD PMID:21887255 RGD:40818252 NCBI chr 6:59,092,258...59,099,992
Ensembl chr 6:59,092,911...59,099,990 		JBrowse link
G PDCD1 programmed cell death 1 treatment ISO RGD PMID:25624454 RGD:40818422 NCBI chr15:140,337,353...140,347,493
Ensembl chr15:140,336,258...140,347,478 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta treatment ISO associated with immunodeficiency 14 RGD PMID:30093657 RGD:40890269 NCBI chr 6:70,026,254...70,086,950
Ensembl chr 6:70,026,373...70,084,742 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma severity ISO RGD PMID:17322108 RGD:38599154 NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 exacerbates ISO RGD PMID:33625952 RGD:127229925 NCBI chr 7:74,951,145...74,955,255
Ensembl chr 7:74,951,145...74,955,251 		JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415 		JBrowse link
viral pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO CTD Direct Evidence: marker/mechanism CTD PMID:15381116 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703 		JBrowse link
G CCL11 chemokine (C-C motif) ligand 11 ISO RGD PMID:20644177 RGD:4140459 NCBI chr12:40,779,906...40,782,862
Ensembl chr12:40,779,173...40,782,893 		JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 ISO RGD PMID:19617401 RGD:4891451 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
G CCL3L1 chemokine (C-C motif) ligand 3-like 1 ISO mRNA:increased expression:bronchoalveolar lavage (human) RGD PMID:32407669 RGD:30296672 NCBI chr12:39,491,999...39,493,345
Ensembl chr12:39,491,914...39,493,774 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 ISO mRNA:increased expression:bronchoalveolar lavage (human) RGD PMID:20957032 PMID:32407669 RGD:30296672 RGD:5130904 NCBI chr12:39,479,190...39,480,511
Ensembl chr12:39,478,882...39,481,082 		JBrowse link
G CCR1 C-C motif chemokine receptor 1 ISO RGD PMID:15254170 RGD:5688163 NCBI chr13:29,227,218...29,233,862
Ensembl chr13:29,227,222...29,233,960 		JBrowse link
G CD68 CD68 molecule ISO mRNA:increased expression:lung,trachea (mouse) RGD PMID:12581500 RGD:40925942 NCBI chr12:52,874,754...52,877,256
Ensembl chr12:52,874,785...52,877,695 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO RGD PMID:17655904 RGD:5135437 NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948 		JBrowse link
G CXCL16 C-X-C motif chemokine ligand 16 ISO mRNA:decreased expression:bronchoalveolar lavage (human) RGD PMID:32407669 RGD:30296672 NCBI chr12:52,145,100...52,150,267 JBrowse link
G CXCL2 chemokine (C-X-C motif) ligand 2 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:19671179 RGD:5134975 NCBI chr 8:70,157,253...70,159,145
Ensembl chr 8:70,157,214...70,159,138 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO mRNA:increased expression:bronchoalveolar lavage (human) RGD PMID:32407669 RGD:30296672 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ISO RGD PMID:17655904 RGD:5135437 NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,501...71,670,271 		JBrowse link
G FGF10 fibroblast growth factor 10 treatment ISO RGD PMID:27322618 RGD:127284849 NCBI chr16:28,695,465...28,779,953
Ensembl chr16:28,695,470...28,777,509 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 ISO protein:increased expression:epithelial stem/progenitor cells (mouse) RGD PMID:27322618 RGD:127284849 NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,713...131,289,425 		JBrowse link
G HMOX1 heme oxygenase 1 ISO mRNA:increased expression:lung RGD PMID:8843786 RGD:4145417
G IFNAR1 interferon alpha and beta receptor subunit 1 disease_progression ISO RGD PMID:21383977 RGD:5490272 NCBI chr13:196,925,731...196,951,398
Ensembl chr13:196,925,734...196,952,239 		JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:25219125 RGD:10450576 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G IL15 interleukin 15 ISO RGD PMID:20335267 RGD:4892670 NCBI chr 8:85,666,963...85,740,980
Ensembl chr 8:85,667,321...85,678,461 		JBrowse link
G IL17RA interleukin 17 receptor A ISO mRNA:decreased expression:bronchoalveolar lavage (human) RGD PMID:32407669 RGD:30296672 NCBI chr 5:69,461,280...69,480,343
Ensembl chr 5:69,461,290...69,480,112 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO mRNA:increased expression:bronchoalveolar lavage (human) RGD PMID:32407669 RGD:30296672
G IL4R interleukin 4 receptor ISO mRNA:decreased expression:bronchoalveolar lavage (human) RGD PMID:32407669 RGD:30296672 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544 		JBrowse link
G LOC110258578 interleukin-1 beta-like ISO mRNA:increased expression:bronchoalveolar lavage (human) RGD PMID:32407669 RGD:30296672
G MIF macrophage migration inhibitory factor ISO RGD PMID:19941385 RGD:4891005 NCBI chr14:49,840,303...49,841,063
Ensembl chr14:49,840,305...49,841,068 		JBrowse link
G TLR9 toll like receptor 9 ISO DNA:SNP:promoter:g.-1237T>C rs5743836 (human) RGD PMID:19539691 RGD:5130766 NCBI chr13:34,353,444...34,370,990
Ensembl chr13:34,349,609...34,357,673 		JBrowse link
G TNF tumor necrosis factor treatment ISO RGD PMID:25219125 RGD:10450576 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15433
    disease of anatomical entity 15103
      Immune & Inflammatory Diseases 5142
        Inflammation 2476
          pneumonia 219
            Cholesterol Pneumonia 0
            Necrotizing Pneumonia 0
            Pneumonia, Ventilator-Associated 1
            aspiration pneumonitis + 0
            bacterial pneumonia + 144
            bronchopneumonia 3
            eosinophilic pneumonia + 0
            idiopathic interstitial pneumonia + 9
            pleuropneumonia 1
            pneumocystosis 14
            toxic pneumonitis 0
            viral pneumonia 25
Path 2
Term Annotations click to browse term
  disease 15433
    disease of anatomical entity 15103
      respiratory system disease 4884
        lower respiratory tract disease 2229
          lung disease 2193
            pneumonia 219
              Cholesterol Pneumonia 0
              Necrotizing Pneumonia 0
              Pneumonia, Ventilator-Associated 1
              aspiration pneumonitis + 0
              bacterial pneumonia + 144
              bronchopneumonia 3
              eosinophilic pneumonia + 0
              idiopathic interstitial pneumonia + 9
              pleuropneumonia 1
              pneumocystosis 14
              toxic pneumonitis 0
              viral pneumonia 25
paths to the root