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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:borna disease
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Accession:DOID:5154 term browser browse the term
Definition:A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located_in central nervous system, has_material_basis_in Borna disease virus (Orthobornavirus bornaense), which is transmitted_by contact with infected oronasal secretions. The infection has_symptom mood disturbances, has_symptom behaviour disturbances, has_symptom cognitive disturbances, has_symptom neurologic disturbances, and has_symptom movement impairment. (DO)
Synonyms:exact_synonym: enzootic encephalomyelitis
 primary_id: MESH:D001890
 xref: EFO:0007178
For additional species annotation, visit the Alliance of Genome Resources.


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borna disease term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldoc aldolase, fructose-bisphosphate C IEP mRNA, protein:decreased expression:cerebellum, Purkinje cell RGD PMID:17182680 RGD:2301132 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,715,489...63,719,133 		JBrowse link
G Atf4 activating transcription factor 4 IEP protein:increased expression:cerebellum RGD PMID:16912310 RGD:32733622 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:113,684,681...113,686,739 		JBrowse link
G Atf6 activating transcription factor 6 IEP protein:increased expression:cerebellum, hippocampus RGD PMID:16912310 RGD:32733622 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:85,462,840...85,640,033 		JBrowse link
G Bdnf brain-derived neurotrophic factor IEP mRNA:decreased expression:hippocampus RGD PMID:11175319 RGD:2325644 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Cd44 CD44 molecule IEP RGD PMID:16612977 RGD:2289373 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 IEP RGD PMID:12053272 RGD:4891998 NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IEP mRNA:increased expression:brain RGD PMID:12053272 RGD:4891998 NCBI chr 8:128,661,294...128,679,048
Ensembl chr 8:128,654,833...128,685,983 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 IEP mRNA,protein:increased expression:cerebellum, hippocampus RGD PMID:16912310 RGD:32733622 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A IEP protein:increased expression:cerebellum,hippocampus RGD PMID:16912310 RGD:32733622 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:144,911,153...144,945,201 		JBrowse link
G Gja1 gap junction protein, alpha 1 IEP RGD PMID:18538309 RGD:7364785 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Gjb6 gap junction protein, beta 6 IEP RGD PMID:18538309 RGD:7364785 NCBI chr15:31,284,561...31,294,552
Ensembl chr15:35,398,770...35,410,849 		JBrowse link
G Igf1 insulin-like growth factor 1 IEP mRNA:increased expression:hippocampus RGD PMID:11175319 RGD:2325644 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764 		JBrowse link
G Il16 interleukin 16 IEP protein:increased expression:brain RGD PMID:14698845 RGD:1354526 NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023 		JBrowse link
G Mif macrophage migration inhibitory factor IEP protein:increased expression:astrocyte RGD PMID:11870869 RGD:1642006 NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121 		JBrowse link
G Mt3 metallothionein 3 IEP RGD PMID:16612977 RGD:2289373 NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080 		JBrowse link
G Ngf nerve growth factor IEP mRNA:decreased expression:hippocampus RGD PMID:11175319 RGD:2325644 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Ntf3 neurotrophin 3 IEP mRNA:decreased expression:hippocampus RGD PMID:11175319 RGD:2325644 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:160,600,770...160,676,349 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IEP mRNA:decreased expression:cerebellum,hippocampus RGD PMID:11175319 RGD:2325644 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 IEP mRNA:decreased expression:cerebellum,hippocampus RGD PMID:11175319 RGD:2325644 NCBI chr 1:141,526,192...141,913,575
Ensembl chr 1:141,542,569...141,913,004 		JBrowse link
G Parg poly (ADP-ribose) glycohydrolase IEP mRNA:decreased expression:hippocampus RGD PMID:18057239 RGD:2316738 NCBI chr16:7,442,696...7,550,585
Ensembl chr16:7,442,726...7,550,584 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 IEP mRNA,protein:increased expression,increased activity:neuron, glial cell: RGD PMID:18057239 RGD:2316738 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G S100b S100 calcium binding protein B IEP protein:decreased expression:cerebellum, cerebral cortex RGD PMID:17376896 RGD:5508841 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,348...12,381,081 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 IEP protein:increased expression:brain (rat) RGD PMID:12106671 RGD:38549588 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056 		JBrowse link
G Xbp1 X-box binding protein 1 IEP mRNA,protein:altered expression:cerebellum,hippocampus RGD PMID:16912310 RGD:32733622 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    Animal Diseases 1797
      borna disease 24
Path 2
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      nervous system disease 14369
        central nervous system disease 12646
          Central Nervous System Infections 344
            borna disease 24
paths to the root