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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:rhinitis
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Accession:DOID:4483 term browser browse the term
Definition:A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip. (DO)
Synonyms:exact_synonym: nasal catarrh;   rhinitides;   runny nose
 primary_id: MESH:D012220
 xref: EFO:0008521;   NCI:C34986
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam33 ADAM metallopeptidase domain 33 susceptibility ISO DNA:SNPs: :multiple (human) RGD PMID:18778489 PMID:15298558 RGD:4145378, RGD:4145383 NCBI chr 3:138,715,428...138,736,392
Ensembl chr 3:138,724,046...138,736,347 		JBrowse link
G Ang angiogenin ISO protein:increased expression:sputum RGD PMID:19178538 RGD:6892723 NCBI chr15:26,786,233...26,796,883
Ensembl chr15:26,786,065...26,801,106 		JBrowse link
G Bdkrb1 bradykinin receptor B1 ISO RGD PMID:12165532 RGD:5129220 NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:130,275,478...130,280,973 		JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO RGD PMID:1890650 PMID:11149999 RGD:4891044, RGD:4891033 NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:130,237,255...130,267,209 		JBrowse link
G Bdnf brain-derived neurotrophic factor susceptibility IEP
ISO 		mRNA:increased expression:nasal cavity epithelium
DNA:SNP,haplotypes: :rs10767664,rs12273539,rs962369(human) 		RGD PMID:20464992 PMID:21723144 RGD:4891116, RGD:8655967 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G C3 complement C3 ISO
IEP 		mRNA:increased expression:nasal cavity epithelium RGD PMID:20109314 PMID:17345707 RGD:5129539, RGD:5129524 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339 		JBrowse link
G C3ar1 complement C3a receptor 1 severity ISO protein:increased expression:nasal cavity RGD PMID:18538384 RGD:5129559 NCBI chr 4:157,747,419...157,756,609
Ensembl chr 4:157,746,089...157,776,323 		JBrowse link
G C5ar1 complement C5a receptor 1 ISO RGD PMID:18538384 RGD:5129559 NCBI chr 1:86,077,309...86,088,001 JBrowse link
G Casp1 caspase 1 ISO protein:increased expression:serum RGD PMID:12396474 PMID:20974310 RGD:5130192, RGD:5130187 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Cat catalase treatment ISO protein:increased activity:blood,nasal cavity mucosa: RGD PMID:21541033 RGD:9479054 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl1 C-C motif chemokine ligand 1 ISO mRNA:increased expression:nasal cavity epithelium RGD PMID:17982926 RGD:4145109 NCBI chr10:67,625,962...67,628,740
Ensembl chr10:67,625,962...67,628,790 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 severity ISO
IEP 		associated with Sinusitis;protein:increased expression:paranasal sinus
protein:increased expression:nasal mucus
mRNA:increased expression:lung, nose 		RGD PMID:17999785 PMID:16120080 PMID:16765544 RGD:4145455, RGD:4145411, RGD:4145462 NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,525,862...67,530,575 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 ISO protein:increased expression:blood, mononuclear cell RGD PMID:17517104 RGD:4145498 NCBI chr19:10,208,120...10,218,340
Ensembl chr19:10,208,120...10,209,895 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 ISO RGD PMID:17947663 RGD:5130909 NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:61,759,220...61,772,022 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 ISO protein:increased expression:blood, mononuclear cell RGD PMID:17517104 RGD:4145498 NCBI chr19:10,263,589...10,270,359
Ensembl chr19:10,263,589...10,270,359 		JBrowse link
G Ccl24 C-C motif chemokine ligand 24 ISO mRNA:increased expression:nasal cavity epithelium
DNA:SNPs: :179T>C, 275C>T (human) 		RGD PMID:17982926 PMID:15580493 RGD:4145109, RGD:4891493 NCBI chr12:26,737,423...26,741,420
Ensembl chr12:26,737,439...26,750,924 		JBrowse link
G Ccl26 C-C motif chemokine ligand 26 ISO DNA:polymorphism: :2497T>G (human)
associated with Eosinophilia;protein:increased expression:oronasal secretion (human) 		RGD PMID:15580493 PMID:24989688 RGD:4891493, RGD:11531119 NCBI chr12:26,745,972...26,750,924 JBrowse link
G Ccl4 C-C motif chemokine ligand 4 ISO RGD PMID:19786211 RGD:5130914 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 ISO RGD PMID:17982926 RGD:4145109 NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 susceptibility ISO Rhinitis, Allergic, Seasonal; DNA:SNP:cds:p.V64I (human) RGD PMID:17135764 RGD:4145111 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 ISO
IEP 		DNA:SNP:exon:51T>C (human)
protein:increased expression:blood, T cell
mRNA:increased expression:nose 		RGD PMID:17135764 PMID:17156343 PMID:20696593 RGD:4145111, RGD:4145645, RGD:4145454 NCBI chr 8:132,463,533...132,511,601
Ensembl chr 8:132,463,788...132,511,593 		JBrowse link
G Cd14 CD14 molecule susceptibility
resistance 		ISO DNA:polymorphism:promoter:c. -159c>T (human) RGD PMID:20109306 PMID:16950285 RGD:4144795, RGD:4144810 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292 		JBrowse link
G Cd28 Cd28 molecule ISO RGD PMID:21356099 RGD:5131612 NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:69,545,326...69,689,192 		JBrowse link
G Cd80 Cd80 molecule ISO RGD PMID:21108691 RGD:5132622 NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540 		JBrowse link
G Cdc42 cell division cycle 42 ISO mRNA:increased expression:nasal turbinate RGD PMID:19432938 RGD:5688273 NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:154,839,631...154,876,627 		JBrowse link
G Cftr CF transmembrane conductance regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:16083808 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO mRNA, protein:increased expression:nasal cavity epithelium RGD PMID:17597629 RGD:5130940 NCBI chr10:89,540,192...89,583,466
Ensembl chr10:89,540,192...89,583,466 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO mRNA, protein:increased expression:nasal cavity epithelium RGD PMID:17597629 RGD:5130940 NCBI chr 4:85,553,163...85,596,203
Ensembl chr 4:85,554,268...85,596,318 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 ISO protein:increased expression:T cell RGD PMID:17625281 RGD:4891512 NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:69,813,265...69,819,973 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO protein:increased expression:plasma RGD PMID:14657873 RGD:4891906 NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 ISO protein:increased expression:nasal mucus RGD PMID:20659080 RGD:4892030 NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,594,959...17,596,417 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO DNA:SNP:3' utr:*1934G>A (human) RGD PMID:20088379 RGD:5143945 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 ISO associated with Sinusitis;mRNA:increased expression:nasal cavity epithelium RGD PMID:17627772 PMID:16689996 PMID:15379985 PMID:18946234 RGD:4781451, RGD:4783198, RGD:4847512, RGD:4888516 NCBI chr  X:75,734,281...75,762,873
Ensembl chr  X:75,734,270...75,763,050 		JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 ISO associated with Sinusitis;mRNA:increased expression:nasal cavity epithelium RGD PMID:16689996 RGD:4783198 NCBI chr15:54,599,043...54,638,314
Ensembl chr15:54,598,818...54,713,597 		JBrowse link
G Fcer1a Fc epsilon receptor Ia ISO RGD PMID:20650300 RGD:5128714 NCBI chr13:88,218,427...88,224,723
Ensembl chr13:88,218,420...88,224,681 		JBrowse link
G Fis1 fission, mitochondrial 1 IEP mRNA, protein:increased expression:nasal cavity mucosa (rat) RGD PMID:28146064 RGD:13204839 NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335 		JBrowse link
G Hdc histidine decarboxylase ISO
IEP 		DNA:SNP: :p.E644D (rs2073440) (human) RGD PMID:20608921 PMID:15054596 RGD:5128884, RGD:5143921 NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:134,300,632...134,318,711 		JBrowse link
G Hnmt histamine N-methyltransferase no_association ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17651147 PMID:17651147 RGD:5128885 NCBI chr 3:26,978,274...27,010,291
Ensembl chr 3:26,977,933...27,010,482 		JBrowse link
G Hrh1 histamine receptor H 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12167471 NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248 		JBrowse link
G Il13 interleukin 13 susceptibility
disease_progression 		ISO
IEP 		associated with asthma; DNA:polymorphisms:promoter:c. -1510A>C, -1055C>T (human)
mRNA:increased expression:nose
DNA:polymorphism: :rs1800925 (human) 		RGD PMID:16120094 PMID:20358028 PMID:20696593 PMID:17088137 PMID:20484924 RGD:4206706, RGD:4145767, RGD:4145454, RGD:4159171, RGD:4145534 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 ISO RGD PMID:17088137 RGD:4159171 NCBI chr  X:115,814,620...115,886,080
Ensembl chr  X:115,814,622...115,841,455 		JBrowse link
G Il15 interleukin 15 ISO RGD PMID:16750998 RGD:5000756 NCBI chr19:42,536,160...42,611,349
Ensembl chr19:42,545,346...42,611,348 		JBrowse link
G Il16 interleukin 16 ISO protein:increased expression:serum
protein:increased expression:nasal cavity epithelium, serum 		RGD PMID:18254318 PMID:19295235 RGD:5024932, RGD:5024931 NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023 		JBrowse link
G Il17a interleukin 17A ISO protein:increased expression:nasal mucosa RGD PMID:20506642 PMID:19927541 RGD:4889137, RGD:4889144 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il18 interleukin 18 disease_progression ISO protein:increased expression:nasal lavage fluid, bronchoalveolar lavage fluid
rhinitis allergic, seasonal; protein:increased expression:plasma
protein:increased expression:serum 		RGD PMID:17305282 PMID:15934281 PMID:17323858 RGD:4889917, RGD:4889927, RGD:4889916 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta susceptibility IEP
ISO 		mRNA:increased expression:nasal cavity epithelium
associated with Hypersensitivity;DNA:polymorphism: :-511C>T (human)
associated with Hypersensitivity;protein:increased expression:nasal mucus 		RGD PMID:20490816 PMID:14533660 PMID:10224452 RGD:4142821, RGD:4142859, RGD:4143227 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 severity ISO associated with Sinusitis;DNA:SNPs: :multiple (human) RGD PMID:19671251 RGD:5144228 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891 		JBrowse link
G Il1rn interleukin 1 receptor antagonist susceptibility ISO associated with Hypersensitivity;DNA:repeat:intron (human) RGD PMID:14533660 PMID:15178892 PMID:10224452 RGD:4142859, RGD:4143215, RGD:4143227 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il2 interleukin 2 susceptibility ISO DNA:SNP:promoter:rs2069762(human) RGD PMID:16333313 RGD:8663473 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il21 interleukin 21 ISO RGD PMID:17982108 RGD:5147397 NCBI chr 2:122,045,240...122,055,142
Ensembl chr 2:122,045,240...122,055,142 		JBrowse link
G Il22 interleukin 22 severity ISO mRNA:increased expression:blood, mononuclear cell RGD PMID:21535180 RGD:5147409 NCBI chr 7:55,687,061...55,691,526
Ensembl chr 7:55,686,896...55,692,201 		JBrowse link
G Il23r interleukin 23 receptor susceptibility ISO DNA:SNP,haplotype: :rs7517847(human) RGD PMID:23696856 RGD:8549605 NCBI chr 4:97,910,230...98,003,759
Ensembl chr 4:97,909,972...98,004,110 		JBrowse link
G Il27ra interleukin 27 receptor subunit alpha ISO RGD PMID:19354069 RGD:5128480 NCBI chr19:41,014,730...41,026,740
Ensembl chr19:41,014,730...41,026,760 		JBrowse link
G Il4 interleukin 4 ISO
IEP 		mRNA:increased expression:nasal cavity epithelium
CTD Direct Evidence: marker/mechanism
protein:increased expression:serum 		CTD
RGD		 PMID:19672097 PMID:21208219 PMID:18826099 RGD:5128558, RGD:2317285 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il4r interleukin 4 receptor ISO DNA:polymorphism: :c.1432T>C (human) RGD PMID:15564773 RGD:4890394 NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:189,544,988...189,570,636 		JBrowse link
G Il5 interleukin 5 ISO RGD PMID:11884474 RGD:5128622 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Il9 interleukin 9 ISO RGD PMID:20525149 RGD:5128687 NCBI chr17:8,117,028...8,120,151
Ensembl chr17:8,117,028...8,120,151 		JBrowse link
G Lep leptin ISO RGD PMID:19860581 RGD:5128850 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Mbl2 mannose binding lectin 2 susceptibility ISO DNA:polymorphism: : RGD PMID:18831943 RGD:8693717 NCBI chr 1:237,429,873...237,465,567
Ensembl chr 1:237,429,973...237,437,546 		JBrowse link
G Mfn1 mitofusin 1 IEP mRNA, protein:increased expression:nasal cavity mucosa (rat) RGD PMID:28146064 RGD:13204839 NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190 		JBrowse link
G Mif macrophage migration inhibitory factor severity ISO protein:increased expression:serum, nasal mucosa RGD PMID:15053202 PMID:15922619 RGD:4891045, RGD:4891056 NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121 		JBrowse link
G Ms4a2 membrane spanning 4-domains A2 ISO RGD PMID:15480314 RGD:5131152 NCBI chr 1:217,864,855...217,873,934
Ensembl chr 1:217,865,159...217,873,108 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming IEP
ISO 		mRNA:increased expression:nose RGD PMID:20696593 PMID:15715404 RGD:4145454, RGD:7364740 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006 		JBrowse link
G Ngf nerve growth factor ISO protein:increased expression:respiratory system fluid/secretion
associated with Sinusitis;protein:increased expression:respiratory system mucosa 		RGD PMID:10224365 PMID:19958603 RGD:4891115, RGD:4891064 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Ngfr nerve growth factor receptor ISO protein:increased expression:blood, eosinophil RGD PMID:18647313 RGD:5144116 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305 		JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 ISO mRNA:decreased expression:nose RGD PMID:20384614 RGD:5131446 NCBI chr 4:85,391,142...85,442,281
Ensembl chr 4:85,391,151...85,441,674 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 susceptibility ISO DNA:polymorphisms:cds:2104C>T,2722G>C (human) RGD PMID:12704363 RGD:5131484 NCBI chr19:34,555,832...34,596,281
Ensembl chr19:34,555,832...34,722,846 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO protein:increased expression:nasal mucosa RGD PMID:18254476 RGD:4891910 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Npy neuropeptide Y ISO CTD Direct Evidence: marker/mechanism CTD PMID:12746121 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 ISO protein:increased expression:eosinophil RGD PMID:18647313 RGD:5144116 NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:175,534,844...175,551,787 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase IEP mRNA, protein:increased expression:nasal cavity mucosa (rat) RGD PMID:28146064 RGD:13204839 NCBI chr11:84,612,943...84,690,025
Ensembl chr11:84,615,340...84,689,955 		JBrowse link
G Plau plasminogen activator, urokinase ISO mRNA:increased expression:nasal cavity epithelium RGD PMID:21339035 RGD:8547809 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030 		JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 ISO RGD PMID:19230460 PMID:19608418 RGD:5135021, RGD:5135017 NCBI chr 1:217,010,183...217,015,044
Ensembl chr 1:216,995,629...217,022,393 		JBrowse link
G RT1-Ba RT1 class II, locus Ba susceptibility ISO DNA:polymorphisms:cds:HLA-DQA1*0201, HLA-DQA1*0302 (human) RGD PMID:14990915 RGD:5147798 NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,576,843...4,581,653 		JBrowse link
G RT1-Bb RT1 class II, locus Bb susceptibility ISO DNA:polymorphism:cds:HLA-DQB1*0602 (human) RGD PMID:14990915 RGD:5147798 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118 		JBrowse link
G Scgb3a2 secretoglobin, family 3A, member 2 ISO protein:increased expression:sputum
mRNA,protein:decreased expression:nasal mucosa 		RGD PMID:17218572 PMID:21385388 RGD:5144232, RGD:5147389 NCBI chr18:36,183,745...36,186,667
Ensembl chr18:36,183,698...36,186,742 		JBrowse link
G Serpine1 serpin family E member 1 susceptibility ISO DNA:polymorphism:promoter:rs1799768 (human) RGD PMID:19063817 RGD:4144832 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Sftpd surfactant protein D susceptibility ISO associated with Hypersensitivity;DNA:polymorphism: :p.M11T (human) RGD PMID:19493231 RGD:4143494 NCBI chr16:17,080,575...17,093,047
Ensembl chr16:17,080,567...17,094,036 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member susceptibility
no_association 		ISO DNA:SNPs: : RGD PMID:17982230 PMID:12018331 RGD:6482262, RGD:6482274 NCBI chr20:4,658,171...4,668,543
Ensembl chr20:4,658,172...4,668,810 		JBrowse link
G Tbxa2r thromboxane A2 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:12167471 NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:9,034,108...9,038,905 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO associated with Sinusitis RGD PMID:18423831 RGD:4145277 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tlr2 toll-like receptor 2 susceptibility
no_association 		ISO DNA:SNPs: :597T>C, 1350T>C (human)
mRNA:decreased expression:nasal mucosa:
associated with Sinusitis;DNA:SNPs: :multiple (human) 		RGD PMID:19763595 PMID:18219831 PMID:19128592 RGD:4145354, RGD:7800742, RGD:4145356 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tlr6 toll-like receptor 6 ISO associated with Asthma;DNA:SNP: :rs2381289 (human) RGD PMID:20815312 RGD:4145352 NCBI chr14:43,715,809...43,727,019
Ensembl chr14:43,698,751...43,740,462 		JBrowse link
G Tnf tumor necrosis factor ISO
IEP 		mRNA:increased expression:nose RGD PMID:15120189 PMID:20696593 RGD:4143470, RGD:4145454 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:sputum RGD PMID:19178538 RGD:6892723 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Vip vasoactive intestinal peptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:12746121 PMID:14680090 NCBI chr 1:44,470,232...44,478,561
Ensembl chr 1:44,470,462...44,478,558 		JBrowse link
allergic rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A severity ISO DNA:snp:exon:c.1236C>T (human) RGD PMID:24040855 RGD:8657076 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Ace angiotensin I converting enzyme no_association ISO DNA:deletion:intron:IVS16+1464-1751del (human) RGD PMID:15112973 RGD:8142345 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Bcl2 BCL2, apoptosis regulator IEP mRNA, protein:increased expression:nasal mucosa (rat) RGD PMID:15362690 RGD:11522724 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Cat catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29028686 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 treatment IDA RGD PMID:23089405 RGD:7248414 NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,525,862...67,530,575 		JBrowse link
G Ccl26 C-C motif chemokine ligand 26 ISO protein:increased expression:oronasal secretion (human) RGD PMID:23883806 RGD:7364793 NCBI chr12:26,745,972...26,750,924 JBrowse link
G Cd40 CD40 molecule ISO protein:increased expression:lymphocyte RGD PMID:19086656 RGD:8547782 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:lymphocyte RGD PMID:19086656 RGD:8547782 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:140,164,302...140,176,475 		JBrowse link
G Cldn3 claudin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33441633 NCBI chr12:27,345,075...27,346,547
Ensembl chr12:27,345,076...27,348,841 		JBrowse link
G Cldn7 claudin 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33441633 NCBI chr10:55,188,670...55,190,871
Ensembl chr10:55,188,684...55,190,905 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 treatment ISO RGD PMID:10436391 RGD:11344920 NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:69,813,265...69,819,973 		JBrowse link
G F2 coagulation factor II, thrombin ISO protein:increased expression:nasal mucus RGD PMID:21711961 RGD:5147783 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246 		JBrowse link
G Fcgr3a Fc gamma receptor 3A susceptibility ISO DNA:polymorphism:exon:p.F158V(rs396991)(human) RGD PMID:18199088 RGD:5508449 NCBI chr13:85,782,636...85,792,656
Ensembl chr13:85,782,490...85,792,651 		JBrowse link
G Flg filaggrin susceptibility ISO associated with atopic dermatitis;DNA:SNP:cds:p.P478S (rs11584340) RGD PMID:21219289 RGD:628398356 NCBI chr 2:181,583,801...181,596,464
Ensembl chr 2:181,583,808...181,595,968 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34624383 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34624383 NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:168,247,496...168,367,616 		JBrowse link
G Hmox1 heme oxygenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36127783 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hrh1 histamine receptor H 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23333628 NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248 		JBrowse link
G Ifng interferon gamma treatment ISO
IDA 		associated with Asthma
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:29871060 PMID:12787306 PMID:18510219 RGD:7829803, RGD:10755770 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Ighe immunoglobulin heavy constant epsilon ISO DNA:mutations:cds: RGD PMID:25171866 RGD:629006504
G Il10 interleukin 10 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:36127783 PMID:23883806 PMID:23253209 RGD:7364793, RGD:7364818 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il13 interleukin 13 susceptibility
no_association 		ISO DNA:polymorphism:exon:c. 2044G>A (human)
CTD Direct Evidence: marker/mechanism
DNA:missense mutation:cds:p.R130Q (rs20541) (human)
DNA:SNPs:promoter, cds:-1112C>T, p.R130Q (rs1800925, rs20541) (human)
DNA:SNP:promoter:-1512A>C (rs1881457) (human) 		CTD
OMIM
RGD		 PMID:17091279 PMID:22852128 PMID:12928861 PMID:23996716 RGD:4152796, RGD:8549518, RGD:8549516, RGD:8549501 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 ISO protein:increased expression:serum RGD PMID:21462799 RGD:8549521 NCBI chr  X:115,814,620...115,886,080
Ensembl chr  X:115,814,622...115,841,455 		JBrowse link
G Il17a interleukin 17A susceptibility ISO DNA:snp:promoter:c.-444A>G (human)
mRNA:increased expression:peripheral blood mononuclear cell (human) 		RGD PMID:22507625 PMID:21535180 RGD:9068429, RGD:5147409 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il18 interleukin 18 severity
no_association 		ISO DNA:SNP:promoter:-137G>C (rs187238) (human)
DNA:SNP:promoter:-140C>G (rs360721) (human) 		RGD PMID:22840759 PMID:22840759 RGD:8655914, RGD:8655914 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:nasal mucus RGD PMID:7750009 RGD:7401199 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il2 interleukin 2 IEP RGD PMID:12592663 RGD:8662963 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il4 interleukin 4 treatment ISO
IEP 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:36127783 PMID:9893928 PMID:24620662 PMID:8908280 PMID:14653048 RGD:7829796, RGD:11522769, RGD:7829827, RGD:7829802 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il5 interleukin 5 treatment IEP RGD PMID:23934070 PMID:24620662 RGD:11354976, RGD:11522769 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Itgb2 integrin subunit beta 2 treatment IEP RGD PMID:12046991 RGD:9698435 NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182 		JBrowse link
G Ltc4s leukotriene C4 synthase ISO DNA:SNP:promoter:g.-444A>C RGD PMID:16730545 RGD:626168264 NCBI chr10:35,060,002...35,066,466
Ensembl chr10:35,061,437...35,063,768 		JBrowse link
G Mrc1 mannose receptor, C type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36127783 NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410 		JBrowse link
G Muc1 mucin 1, cell surface associated severity ISO
IMP
IEP 		mRNA,protein:decreased expression:nasal mucosa RGD PMID:31425778 PMID:31425778 PMID:31425778 RGD:127345100, RGD:127345100, RGD:127345100 NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:176,933,047...176,938,491 		JBrowse link
G Muc1em1Cgen mucin 1, cell surface associated; TALEN induced mutant 1, Cgen severity IMP RGD PMID:31425778 RGD:127345100
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming IEP mRNA, protein:increased expression:nasal cavity epithelium RGD PMID:22972875 RGD:7364746 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO mRNA:increased expression:nasal mucosa (human) RGD PMID:23858718 RGD:8547523 NCBI chr19:34,555,832...34,596,281
Ensembl chr19:34,555,832...34,722,846 		JBrowse link
G Ocln occludin ISO CTD Direct Evidence: marker/mechanism CTD PMID:33441633 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411 		JBrowse link
G Pon1 paraoxonase 1 severity ISO protein:decreased activity:plasma (human) RGD PMID:23406590 RGD:8547583 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 IEP protein:increased expression:nasal cavity epithelium RGD PMID:24012634 RGD:7775060 NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:237,823,053...239,103,005 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16979129 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rora RAR-related orphan receptor A ameliorates ISO DNA:SNP:multiple:multiple RGD PMID:35636076 RGD:626469566 NCBI chr 8:78,182,710...78,915,730
Ensembl chr 8:78,182,620...78,915,730 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 ISO RGD PMID:20487636 RGD:5144132 NCBI chr20:1,329,227...1,333,394
Ensembl chr20:1,329,225...1,333,366 		JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 ISO mRNA:decreased expression:nasal mucosa, lung RGD PMID:17882576 RGD:5144135 NCBI chr 1:215,406,138...215,409,686
Ensembl chr 1:215,406,138...215,409,686 		JBrowse link
G Scgb3a2 secretoglobin, family 3A, member 2 susceptibility ISO DNA:SNP: :rs7726552 (human) RGD PMID:21410962 RGD:5144225 NCBI chr18:36,183,745...36,186,667
Ensembl chr18:36,183,698...36,186,742 		JBrowse link
G Serpine1 serpin family E member 1 ISO mRNA:increased expression:nasal mucosa (mouse) RGD PMID:21339035 RGD:8547809 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Tacr1 tachykinin receptor 1 IEP mRNA:increased expression:nasal mucosa RGD PMID:12768696 RGD:5147835 NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:116,478,617...116,647,492 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 treatment IEP RGD PMID:31368266 RGD:14995445 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tlr2 toll-like receptor 2 severity ISO DNA:polymorphism:cds:p.R753Q(human)
protein:increased expression:neutrophil:
mRNA:decreased expression:nasal mucosa: 		RGD PMID:22402138 PMID:22555057 PMID:18381801 PMID:18219831 RGD:7800732, RGD:8552993, RGD:8552972, RGD:7800742 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tlr4 toll-like receptor 4 severity
treatment
susceptibility
no_association 		ISO DNA:polymorphism:cds:p.D299G(human)
protein:increased expression:nasal lavage,leukocyte, bone marrow:
protein:decreased expression:nasal mucosa:
DNA:SNP: :rs1927911(human)
DNA:polymorphism: :4216G>C(human) 		RGD PMID:22402138 PMID:22555057 PMID:22577387 PMID:17069098 PMID:23639307 More... RGD:7800732, RGD:8552993, RGD:7800740, RGD:7800738, RGD:7800736, RGD:4145354 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tlr9 toll-like receptor 9 ISO protein:decreased expression:nasal mucosa: RGD PMID:22577387 RGD:7800740 NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:115,742,889...115,750,148 		JBrowse link
Allergic Rhinoconjunctivitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 treatment ISO associated with Eosinophilic Esophagitis; DNA:polymorphisms:: RGD PMID:26416193 RGD:11352743 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Il3 interleukin 3 susceptibility ISO DNA:SNP: :rs40401(human) RGD PMID:23953855 RGD:13506915 NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,906,460...38,908,810 		JBrowse link
chronic rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 ISO protein:increased expression:inferior turbinate, nasal gland, inflammatory cell (human) RGD PMID:8845175 RGD:8661738 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
Chronic Rhinosinusitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd8a CD8 subunit alpha ameliorates ISO protein:decreased expression:blood, T cell (human) RGD PMID:24639246 RGD:124715444 NCBI chr 4:104,924,116...104,928,353
Ensembl chr 4:104,900,833...104,928,358 		JBrowse link
G Cdhr3 cadherin-related family member 3 ISO DNA:SNP:intron:rs6967330 RGD PMID:34076350 RGD:626467892 NCBI chr 6:55,369,215...55,429,454
Ensembl chr 6:55,369,851...55,429,458 		JBrowse link
G Glcci1 glucocorticoid induced 1 treatment ISO DNA:SNP: :rs37973 RGD PMID:30256538 RGD:628359914 NCBI chr 4:37,274,271...37,601,898
Ensembl chr 4:37,529,364...37,599,802
Ensembl chr 4:37,529,364...37,599,802 		JBrowse link
G Il17a interleukin 17A ISO protein:increased expression:uncinate process, nasal mucosa (human) RGD PMID:23613503 RGD:8696039 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il1rn interleukin 1 receptor antagonist susceptibility ISO DNA:repeats:intron:IVS2+914_1000dup I/II alleles (human) RGD PMID:16549749 RGD:8549791 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Ltc4s leukotriene C4 synthase ISO mRNA:increased expression:sinonasal mucosa RGD PMID:15940133 RGD:626168282 NCBI chr10:35,060,002...35,066,466
Ensembl chr10:35,061,437...35,063,768 		JBrowse link
G Mbl2 mannose binding lectin 2 ISO protein:decreased activity:serum: RGD PMID:23144819 RGD:8693716 NCBI chr 1:237,429,873...237,465,567
Ensembl chr 1:237,429,973...237,437,546 		JBrowse link
G Prg2 proteoglycan 2, pro eosinophil major basic protein disease_progression ISO associated with Nasal Polyps; RGD PMID:24450586 RGD:13506943 NCBI chr 3:90,469,192...90,472,759
Ensembl chr 3:90,469,176...90,472,752 		JBrowse link
chronic rhinosinusitis with nasal polyps term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase treatment ISO RGD PMID:23751068 RGD:626419675 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126 		JBrowse link
G Glcci1 glucocorticoid induced 1 treatment ISO DNA:SNP: :rs37973 RGD PMID:30256538 RGD:628359914 NCBI chr 4:37,274,271...37,601,898
Ensembl chr 4:37,529,364...37,599,802
Ensembl chr 4:37,529,364...37,599,802 		JBrowse link
G Il4 interleukin 4 treatment ISO RGD PMID:23751068 RGD:626419675 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il5 interleukin 5 treatment ISO RGD PMID:23751068 RGD:626419675 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Ltc4s leukotriene C4 synthase treatment ISO RGD PMID:23751068 RGD:626419675 NCBI chr10:35,060,002...35,066,466
Ensembl chr10:35,061,437...35,063,768 		JBrowse link
G Ptgds prostaglandin D2 synthase treatment ISO RGD PMID:23751068 RGD:626419675 NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:28,680,044...28,682,978 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 treatment ISO RGD PMID:23751068 RGD:626419675 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Spink5 serine peptidase inhibitor, Kazal type 5 ISO mRNA, protein:decreased expression:nasal cavity mucosa
associated with aspirin-induced respiratory disease;mRNA:decreased expression:nasal cavity mucosa 		RGD PMID:18588753 PMID:22570283 RGD:628359029, RGD:628359036 NCBI chr18:36,515,347...36,584,038
Ensembl chr18:36,515,347...36,583,799 		JBrowse link
eosinophilic chronic rhinosinusitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csta cystatin A ISO mRNA, protein:decreased expression:nasal cavity epithelium
protein:decreased expression:nose, oronasal secretion 		RGD PMID:27779422 PMID:27779422 RGD:628359037, RGD:628359037 NCBI chr11:78,125,813...78,136,818
Ensembl chr11:78,125,800...78,136,822 		JBrowse link
G Glcci1 glucocorticoid induced 1 treatment ISO DNA:SNP: :rs37973 RGD PMID:30256538 RGD:628359914 NCBI chr 4:37,274,271...37,601,898
Ensembl chr 4:37,529,364...37,599,802
Ensembl chr 4:37,529,364...37,599,802 		JBrowse link
G Spink5 serine peptidase inhibitor, Kazal type 5 ISO mRNA, protein:decreased expression:nasal cavity epithelium
protein:decreased expression:nose, oronasal secretion 		RGD PMID:27779422 PMID:27779422 RGD:628359037, RGD:628359037 NCBI chr18:36,515,347...36,584,038
Ensembl chr18:36,515,347...36,583,799 		JBrowse link
Perennial Allergic Rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:decreased expression:serum RGD PMID:19725899 RGD:5686851 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Alb albumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19389874 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein ISO protein:increased expression:nasal turbinate RGD PMID:19364335 RGD:5147461 NCBI chr12:10,785,254...10,809,295
Ensembl chr12:10,785,257...10,817,038 		JBrowse link
G Cat catalase ISO protein:decreased expression:plasma RGD PMID:20493834 RGD:5130771 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO protein:increased expression:nasal turbinate, mucosa (human) RGD PMID:9865755 RGD:8548839 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO mRNA:increased expression:Nasal Mucosa RGD PMID:17982926 RGD:4145109 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO mRNA:increased expression:nasal mucosa (human) RGD PMID:17982926 RGD:4145109 NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:132,629,683...132,637,594 		JBrowse link
G Cd40 CD40 molecule ISO RGD PMID:20226305 RGD:5132269 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cd86 CD86 molecule ISO protein:increased expression:nasal mucosa, dendritic cell (human) RGD PMID:17088138 RGD:4892343 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361 		JBrowse link
G Chia chitinase, acidic ISO mRNA, protein:increased expression:turbinate, mucosa (human) RGD PMID:20422678 RGD:5037226 NCBI chr 2:196,302,687...196,344,849
Ensembl chr 2:196,302,545...196,344,850 		JBrowse link
G Egr1 early growth response 1 ISO DNA:snp:5' utr:g.-4071A>G rs7729723 (human) RGD PMID:19833116 RGD:5131984 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO RGD PMID:17727088 RGD:4892590 NCBI chr 2:28,507,003...28,519,954
Ensembl chr 2:28,507,003...28,519,954 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 susceptibility ISO DNA:polymorphism:exon:p.I105V (rs1695) (human) RGD PMID:17181111 RGD:4142523 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Hmox1 heme oxygenase 1 ISO mRNA, protein:increased expression: nasal mucosa RGD PMID:16540907 RGD:4145406 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:lung, endothelium (mouse)
protein:increased secretion:nasopharynx (human) 		RGD PMID:19968652 PMID:19047814 RGD:4145464, RGD:4145520 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifngr1 interferon gamma receptor 1 ISO DNA: SNP: Leu467Pro RGD PMID:12851715 RGD:6480431 NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:16,152,879...16,171,437 		JBrowse link
G Il13 interleukin 13 ISO mRNA, protein:increased expression:nasal mucosa RGD PMID:8520776 RGD:4782826 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il17a interleukin 17A severity ISO protein:increased expression:serum RGD PMID:19226302 RGD:4889151 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il18 interleukin 18 susceptibility ISO DNA:SNP:promoter:c. -607A>C (rs1946518) (human) RGD PMID:16406079 RGD:4889924 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1a interleukin 1 alpha ISO DNA:polymorphism:exon:c.4845G>T (human) RGD PMID:14533660 RGD:4142859 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 ISO RGD PMID:18637763 RGD:5037238 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579 		JBrowse link
G Il2 interleukin 2 ISO protein:decreased expression:serum: RGD PMID:17608155 RGD:8662959 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il4 interleukin 4 treatment ISO protein:increased expression:serum RGD PMID:21171297 PMID:9237816 PMID:15329007 RGD:5128559, RGD:7829817, RGD:7829804 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il5 interleukin 5 ISO protein: increased levels: sputum RGD PMID:22186238 RGD:5687140 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:increased expression:nasal mucosa: RGD PMID:19786210 RGD:5130872 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:nasal mucosa: RGD PMID:19786210 RGD:5130872 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO protein:increased expression:nasal mucosa RGD PMID:14587983 RGD:4892078 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO DNA:snp:promoter:g.-786T>C (human) RGD PMID:18086269 RGD:4892054 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 ISO protein:altered expression:nasal mucosa RGD PMID:20185258 RGD:4892593 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO mRNA, protein:increased expression:nasal mucosa (human) RGD PMID:17116814 RGD:8552811 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression:respiratory system epithelium RGD PMID:19364335 RGD:5147461 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Tbxa2r thromboxane A2 receptor treatment ISO RGD PMID:15247523 RGD:11059532 NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:9,034,108...9,038,905 		JBrowse link
Rhinosinusitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 ISO associated with Nasal Polyps RGD PMID:22279949 RGD:7421555 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831 		JBrowse link
G C3 complement C3 ISO protein:increased expression:serum RGD PMID:19593977 RGD:4889484 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339 		JBrowse link
G C4a complement C4A (Rodgers blood group) disease_progression ISO DNA:deletion: : RGD PMID:16879240 RGD:5688262 NCBI chr20:4,010,306...4,024,707 JBrowse link
G Ccl20 C-C motif chemokine ligand 20 ISO RGD PMID:16702571 RGD:7483585 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736 		JBrowse link
G Hgf hepatocyte growth factor susceptibility ISO DNA:haplotype::rs38850,rs38855,rs38857(human) RGD PMID:20416453 RGD:8548615 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO mRNA:increased expression:nose: RGD PMID:20713758 RGD:8548883 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764 		JBrowse link
G Il10 interleukin 10 ISO protein:decreased expression:blood, mononuclear cell RGD PMID:23168151 RGD:7364820 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il17a interleukin 17A ISO associated with Asthma;mRNA, protein:increased expression:nasal polyps (human) RGD PMID:19672092 RGD:4889146 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:nasal cavity epithelium RGD PMID:11197112 RGD:7401169 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il22ra1 interleukin 22 receptor subunit alpha 1 susceptibility ISO DNA:SNPs:5' utr, intron: (rs4292900, rs16829225, rs4648936) (human) RGD PMID:19393422 RGD:5147411 NCBI chr 5:153,245,067...153,269,865
Ensembl chr 5:153,245,002...153,271,683 		JBrowse link
G Il4 interleukin 4 treatment ISO associated with Asthma RGD PMID:12787306 RGD:7829803 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:23401274 RGD:8547880 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming treatment IDA RGD PMID:23131200 PMID:19389874 RGD:7349403, RGD:7364734 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006 		JBrowse link
G Prkra protein activator of interferon induced protein kinase EIF2AK2 severity ISO associated with Nasal Polyps RGD PMID:22961479 RGD:7777146 NCBI chr 3:81,982,669...82,002,028
Ensembl chr 3:81,982,673...82,001,525 		JBrowse link
G Serpine1 serpin family E member 1 ISO protein:increased expression:nasal mucosa (human) RGD PMID:21711960 RGD:6483796 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Tlr2 toll-like receptor 2 susceptibility ISO mRNA,protein:increased expression:paranasal sinus
DNA:polymorphisms:: rs3804099,rs3804100(human) 		RGD PMID:22182736 PMID:21493395 RGD:7800733, RGD:8552975 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tlr4 toll-like receptor 4 ISO mRNA,protein:increased expression:paranasal sinus RGD PMID:22182736 RGD:7800733 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:nasal cavity epithelium RGD PMID:11197112 PMID:20147558 RGD:7401169, RGD:7401236 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Rhinosinusitis, Allergic Fungal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-Bb RT1 class II, locus Bb ISO DNA:polymorphisms, haplotypes:cds:HLA-DQB1*0301, HLA-DQB1*0302 (human) RGD PMID:15577839 RGD:5147654 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118 		JBrowse link
Seasonal Allergic Rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase ISO RGD PMID:16677242 RGD:5147463 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126 		JBrowse link
G Apoa4 apolipoprotein A4 resistance ISO protein:increased expression:blood serum (human) RGD PMID:20810159 RGD:5685642 NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164 		JBrowse link
G Bdnf brain-derived neurotrophic factor severity ISO protein:increased expression:blood, nasal cavity epithelium RGD PMID:18266897 RGD:5144117 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased expression:inferior turbinate, epithelium (human) RGD PMID:20459697 RGD:4891379 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Cma1 chymase 1 ISO protein:increased expression:nasal mucosa, mast cell (human) RGD PMID:11549546 RGD:5128839 NCBI chr15:33,387,351...33,390,133
Ensembl chr15:33,387,351...33,390,133 		JBrowse link
G Fga fibrinogen alpha chain ISO RGD PMID:21887273 RGD:5688767 NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577 		JBrowse link
G Glcci1 glucocorticoid induced 1 treatment ISO DNA:SNP: :rs37973 RGD PMID:29981236 RGD:628359913 NCBI chr 4:37,274,271...37,601,898
Ensembl chr 4:37,529,364...37,599,802
Ensembl chr 4:37,529,364...37,599,802 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 ISO protein:decreased expression;T lymphocyte: RGD PMID:21410266 RGD:5491008 NCBI chr 1:256,662,377...256,672,515
Ensembl chr 1:256,662,531...256,676,167 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased secretion:nasopharynx, secretion (human) RGD PMID:20128420 RGD:4145459 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifngr1 interferon gamma receptor 1 ISO DNA: SNP: Leu467Pro RGD PMID:12851715 RGD:6480431 NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:16,152,879...16,171,437 		JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:19505388 RGD:7365025 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il18 interleukin 18 susceptibility
no_association 		ISO DNA:SNPs:promoters, exon:multiple
DNA:SNPs:promoters:multiple 		RGD PMID:12532106 PMID:12532106 RGD:8655871, RGD:8655871 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il4 interleukin 4 ISO protein:increased expression:serum
mRNA:increased expression:nose: 		RGD PMID:9237816 PMID:7551298 RGD:7829817, RGD:8662960 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Kdr kinase insert domain receptor ISO protein:increased expression:nasal cavity of mucosa: RGD PMID:17651148 RGD:8551771 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192 		JBrowse link
G Mc1r melanocortin 1 receptor no_association ISO RGD PMID:20357480 RGD:5687317 NCBI chr19:68,360,950...68,363,877
Ensembl chr19:68,360,950...68,363,877 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO DNA:SNPs:promoter, intron, cds:-1590C>T, 2127G>T, p.R668Q (rs3918242, rs2274755, rs17577) (human) RGD PMID:22237587 RGD:8547819 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 susceptibility ISO DNA:SNP: :rs2075817 (human) RGD PMID:16918516 RGD:5131519 NCBI chr 4:85,391,142...85,442,281
Ensembl chr 4:85,391,151...85,441,674 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 susceptibility ISO DNA:polymorphisms:5'UTR/exon, exon:rs5743266, rs2066842 (human) RGD PMID:16008671 RGD:5131477 NCBI chr19:34,555,832...34,596,281
Ensembl chr19:34,555,832...34,722,846 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression:respiratory system epithelium RGD PMID:19364335 RGD:5147461 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G RT1-Bb RT1 class II, locus Bb susceptibility ISO DNA:polymorphism:cds:HLA-DQB1*05 (human)
DNA:polymorphisms, haplotype:cds:HLA-DQB1*0301, HLA-DQB1*0501 (human) 		RGD PMID:22032123 PMID:9641569 RGD:7421561, RGD:7421576 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118 		JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 ISO mRNA, protein:decreased expression:nasal lavage fluid RGD PMID:15836756 RGD:5144234 NCBI chr 1:215,406,138...215,409,686
Ensembl chr 1:215,406,138...215,409,686 		JBrowse link
G Tlr3 toll-like receptor 3 ISO protein:decreased expression:bone marrow, blood, eosinophil (human) RGD PMID:19752565 RGD:5129130 NCBI chr16:53,554,916...53,572,321
Ensembl chr16:53,555,131...53,568,385 		JBrowse link
G Tlr4 toll-like receptor 4 susceptibility ISO DNA:polymorphisms:cds:p.D299G, T399I (human) RGD PMID:18517079 RGD:4144192 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO mRNA,protein:increased expression:nasal biopsies,nasal lavage fluid: RGD PMID:12633568 RGD:7483595 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14566
    Pathological Conditions, Signs and Symptoms 9149
      Pathologic Processes 5472
        Inflammation 2371
          rhinitis 164
            Immotile Cilia Syndrome, due to Excessively Long Cilia 0
            Rhinosinusitis + 32
            allergic rhinitis + 90
            atrophic rhinitis 0
            chronic rhinitis 1
            vasomotor rhinitis 0
Path 2
Term Annotations click to browse term
  disease 14566
    Pathological Conditions, Signs and Symptoms 9149
      Signs and Symptoms 6804
        Neurologic Manifestations 5934
          sensory system disease 4800
            Otorhinolaryngologic Diseases 1186
              nose disease 228
                nasal cavity disease 182
                  rhinitis 164
                    Immotile Cilia Syndrome, due to Excessively Long Cilia 0
                    Rhinosinusitis + 32
                    allergic rhinitis + 90
                    atrophic rhinitis 0
                    chronic rhinitis 1
                    vasomotor rhinitis 0
paths to the root