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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:lung adenocarcinoma
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Accession:DOID:3910 term browser browse the term
Definition:A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin. (DO)
Synonyms:exact_synonym: LUAD;   adenocarcinoma of lung;   bronchogenic lung adenocarcinoma;   non-small cell lung adenocarcinoma;   nonsmall cell adenocarcinoma;   pulmonary adenocarcinoma
 related_synonym: adenocarcinoma of lung, somatic
 primary_id: MESH:D000077192
 xref: EFO:0000571;   EFO:0005288;   GARD:5742;   NCI:C129299;   NCI:C27745;   NCI:C3512
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
lung adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCE1 ATP binding cassette subfamily E member 1 severity ISO mRNA, protein:increased expression:lung (human) RGD PMID:18788636 RGD:11046260 NCBI chr 8:83,302,055...83,353,208
Ensembl chr 8:83,299,322...83,353,109 		JBrowse link
G ACSL4 acyl-CoA synthetase long chain family member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr  X:89,760,863...89,838,103
Ensembl chr  X:89,760,866...89,806,274 		JBrowse link
G ADAM19 ADAM metallopeptidase domain 19 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr16:65,715,445...65,814,761
Ensembl chr16:65,715,517...65,814,758 		JBrowse link
G ADAM28 ADAM metallopeptidase domain 28 exacerbates
disease_progression
treatment		 ISO protein:increased expression:lung RGD PMID:20112342 PMID:26800504 PMID:29882245 PMID:30190423 RGD:11531771 RGD:153297792 RGD:153297794 RGD:153297795 NCBI chr14:8,375,169...8,438,622
Ensembl chr14:8,375,212...8,438,615 		JBrowse link
G ADAMTSL3 ADAMTS like 3 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 7:51,006,356...51,363,855
Ensembl chr 7:51,006,366...51,363,620 		JBrowse link
G ADGRG6 adhesion G protein-coupled receptor G6 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 1:22,662,009...22,802,166
Ensembl chr 1:22,662,022...22,801,848 		JBrowse link
G AHCY adenosylhomocysteinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr17:37,726,084...37,744,378
Ensembl chr17:37,726,084...37,744,461 		JBrowse link
G AHR aryl hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:12597446 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943 		JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 disease_progression ISO RGD PMID:30727821 RGD:27226687 NCBI chr 6:165,811,245...165,825,168
Ensembl chr 6:165,811,247...165,824,896 		JBrowse link
G ALB albumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696 		JBrowse link
G ALDH18A1 aldehyde dehydrogenase 18 family member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr14:107,174,062...107,221,373
Ensembl chr14:107,170,689...107,221,215 		JBrowse link
G ALDOA aldolase, fructose-bisphosphate A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 3:18,246,036...18,260,167
Ensembl chr 3:18,253,384...18,260,163 		JBrowse link
G ALK ALK receptor tyrosine kinase ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 3:109,411,146...110,105,755 JBrowse link
G ALOX12B arachidonate 12-lipoxygenase, 12R type ISO CTD Direct Evidence: marker/mechanism CTD PMID:30258081 NCBI chr12:53,292,530...53,302,850
Ensembl chr12:53,292,526...53,302,993 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:30258081 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,019...90,907,090 		JBrowse link
G ALX1 ALX homeobox 1 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 5:96,761,683...96,785,125
Ensembl chr 5:96,763,685...96,785,165 		JBrowse link
G ALX4 ALX homeobox 4 disease_progression ISO RGD PMID:18978557 RGD:153350135 NCBI chr 2:18,070,726...18,085,685
Ensembl chr 2:18,037,401...18,085,683 		JBrowse link
G ANAPC2 anaphase promoting complex subunit 2 severity ISO mRNA:decreased expression:lung (human) RGD PMID:12036940 RGD:14696682
G ANP32A acidic nuclear phosphoprotein 32 family member A ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 1:166,664,251...166,703,814 JBrowse link
G ANXA1 annexin A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 1:226,414,200...226,431,963
Ensembl chr 1:226,414,306...226,432,279 		JBrowse link
G ANXA5 annexin A5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750 		JBrowse link
G APC APC regulator of WNT signaling pathway ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 2:116,913,354...116,985,303
Ensembl chr 2:116,812,582...117,034,887 		JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 7:78,451,845...78,454,938
Ensembl chr 7:78,451,851...78,454,938 		JBrowse link
G APOA1 apolipoprotein A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713 		JBrowse link
G APOBEC3B apolipoprotein B mRNA editing enzyme catalytic subunit 3B ISO CTD Direct Evidence: marker/mechanism CTD PMID:23852168 NCBI chr 5:9,098,676...9,115,965
Ensembl chr 5:9,097,719...9,116,369 		JBrowse link
G APOC3 apolipoprotein C3 ISO protein:altered glycosylation:: RGD PMID:19322776 RGD:153344619 NCBI chr 9:44,211,171...44,213,538
Ensembl chr 9:44,211,194...44,213,533 		JBrowse link
G AQP4 aquaporin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 6:111,407,632...111,422,169
Ensembl chr 6:111,407,639...111,422,109 		JBrowse link
G ARG1 arginase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 1:32,006,035...32,028,983
Ensembl chr 1:32,006,046...32,028,988 		JBrowse link
G ARHGAP35 Rho GTPase activating protein 35 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr 6:52,711,463...52,841,295
Ensembl chr 6:52,711,901...52,841,288 		JBrowse link
G ARHGAP44 Rho GTPase activating protein 44 ISO mRNA:decreased expression:lung (human) RGD PMID:28527113 RGD:401901290 NCBI chr12:57,049,900...57,206,706
Ensembl chr12:57,049,895...57,206,889 		JBrowse link
G ATP5PD ATP synthase peripheral stalk subunit d ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr12:6,241,467...6,247,344 JBrowse link
G ATRX ATRX chromatin remodeler disease_progression ISO RGD PMID:31374064 RGD:127285382 NCBI chr  X:61,584,028...61,872,341
Ensembl chr  X:61,584,848...61,872,287 		JBrowse link
G AXIN2 axin 2 susceptibility
disease_progression		 ISO DNA:SNP:cds:p.P50S(human)
DNA:SNPs::1712 +19 G>A,148 C>T(human)		 RGD PMID:16820935 PMID:30346805 RGD:151356655 RGD:151356657 NCBI chr12:12,311,293...12,343,207
Ensembl chr12:12,311,298...12,343,200 		JBrowse link
G AZGP1 alpha-2-glycoprotein 1, zinc-binding ISO mRNA,protein:increased expression:lung RGD PMID:17724461 RGD:153350134 NCBI chr 3:7,867,521...7,874,857 JBrowse link
G B2M beta-2-microglobulin ISO ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:26619011 NCBI chr 1:126,865,767...126,878,501
Ensembl chr 1:126,864,468...126,871,554 		JBrowse link
G BAP1 BRCA1 associated deubiquitinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231345 NCBI chr13:34,544,570...34,553,538
Ensembl chr13:34,544,581...34,553,483 		JBrowse link
G BHLHE41 basic helix-loop-helix family member e41 ISO mRNA:decreased expression:lung (human) RGD PMID:18223678 RGD:151665316 NCBI chr 5:47,687,662...47,692,761
Ensembl chr 5:47,686,404...47,692,762 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 exacerbates ISO mRNA:increased expression:B cell (human) RGD PMID:33098370 RGD:153323293 NCBI chr 9:33,003,570...33,020,252
Ensembl chr 9:33,002,734...33,020,242 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 ameliorates
disease_progression		 ISO mRNA:increased expression:lung (human) RGD PMID:31964418 RGD:153344516 NCBI chr12:3,747,276...3,755,214
Ensembl chr12:3,747,279...3,755,215 		JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase ISO ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:12068308 PMID:12198537 PMID:12447372 PMID:12460918 PMID:12460919 More... NCBI chr18:8,957,963...9,132,558
Ensembl chr18:8,957,991...9,132,553 		JBrowse link
G BTK Bruton tyrosine kinase exacerbates
susceptibility		 ISO mRNA:decreased expression:lung (human) RGD PMID:31803536 PMID:32351880 RGD:151347848 RGD:151347849 NCBI chr  X:82,981,512...83,014,475
Ensembl chr  X:82,981,515...83,014,573 		JBrowse link
G BZW2 basic leucine zipper and W2 domains 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 9:85,887,801...85,947,414
Ensembl chr 9:85,886,158...85,947,410 		JBrowse link
G CADM1 cell adhesion molecule 1 ISO DNA, mRNA:hypermethylation, decreased expression:promoter:liver RGD PMID:16814249 RGD:2289096 NCBI chr 9:42,644,487...42,984,934
Ensembl chr 9:42,644,431...42,985,017 		JBrowse link
G CALR calreticulin treatment ISO human cells and recombinant gene in a mouse model RGD PMID:18245558 RGD:150521698 NCBI chr 2:66,098,263...66,102,074
Ensembl chr 2:66,098,229...66,102,132 		JBrowse link
G CAPG capping actin protein, gelsolin like ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 3:59,335,483...59,366,855
Ensembl chr 3:59,339,966...59,366,846 		JBrowse link
G CBX5 chromobox 5 disease_progression ISO mRNA,protein:increased expression:lung: RGD PMID:22900142 RGD:9586743 NCBI chr 5:19,446,083...19,484,527
Ensembl chr 5:19,446,086...19,484,463 		JBrowse link
G CBX7 chromobox 7 ISO mRNA,DNA:decreased expression, loss of heterozygosity:lung: RGD PMID:22214847 RGD:9587356 NCBI chr 5:9,070,312...9,090,467
Ensembl chr 5:9,070,353...9,087,634 		JBrowse link
G CCND1 cyclin D1 disease_progression
treatment		 ISO RGD PMID:19355812 PMID:26681199 RGD:11536846 RGD:13434927 NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296 		JBrowse link
G CCND2 cyclin D2 disease_progression ISO RGD PMID:30308939 RGD:151665105 NCBI chr 5:66,092,483...66,114,575
Ensembl chr 5:66,087,379...66,114,571 		JBrowse link
G CCT5 chaperonin containing TCP1 subunit 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr16:72,211,452...72,223,202
Ensembl chr16:72,208,012...72,223,114 		JBrowse link
G CD163 CD163 molecule ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 5:63,300,200...63,334,497
Ensembl chr 5:63,300,231...63,334,498 		JBrowse link
G CD44 CD44 molecule disease_progression ISO mRNA:splice variants:lung
mRNA:increased expression:lung (human)		 RGD PMID:18091389 PMID:29537891 RGD:149735539 RGD:2289345 NCBI chr 2:25,788,699...25,884,209
Ensembl chr 2:25,788,703...25,884,153 		JBrowse link
G CDC73 cell division cycle 73 exacerbates ISO mRNA:decreased expression:lung (human) RGD PMID:21692036 RGD:150537041 NCBI chr10:575,075...667,618
Ensembl chr10:575,075...667,432 		JBrowse link
G CDH1 cadherin 1 ISO DNA:increased methylation RGD PMID:16329148 RGD:1599556 NCBI chr 6:18,075,487...18,155,986
Ensembl chr 6:18,075,480...18,155,986 		JBrowse link
G CDK12 cyclin dependent kinase 12 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar NCBI chr12:22,755,365...22,831,397
Ensembl chr12:22,775,226...22,831,333 		JBrowse link
G CDK4 cyclin dependent kinase 4 ISO ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:5377176 PMID:7652577 PMID:8528263 PMID:8968104 PMID:9228064 More... NCBI chr 5:23,039,206...23,041,959
Ensembl chr 5:23,038,891...23,042,061 		JBrowse link
G CDK6 cyclin dependent kinase 6 ISO protein:increased expression:lung RGD PMID:10574260 RGD:13464325 NCBI chr 9:72,510,858...72,765,631
Ensembl chr 9:72,518,101...72,764,129 		JBrowse link
G CHD4 chromodomain helicase DNA binding protein 4 ameliorates
susceptibility		 ISO mRNA:increased expression:lung (human)
human cells in a mouse model
DNA:missense mutation:CDS:p.D140E (rs7479004) (human)		 RGD PMID:28486105 PMID:29667179 PMID:32228507 RGD:151660359 RGD:153323299 RGD:153323307 NCBI chr 5:64,071,627...64,105,212
Ensembl chr 5:64,065,992...64,105,173 		JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit susceptibility ISO associated with smoking; DNA:SNP: :rs1051730(human)
ClinVar Annotator: match by term: Lung adenocarcinoma
DNA:SNP: :rs8042374(human)		 RGD
ClinVar		 PMID:20554942 PMID:24686516 PMID:27993330 RGD:150527848 RGD:151347530 NCBI chr 7:47,361,710...47,382,743
Ensembl chr 7:47,361,899...47,384,303 		JBrowse link
G CHRNA5 cholinergic receptor nicotinic alpha 5 subunit susceptibility
disease_progression		 ISO DNA:SNP: :rs503464(human)
ClinVar Annotator: match by term: Lung adenocarcinoma
associated with smoking; DNA:SNPs: :rs2036527, rs684513, rs667282(human)
DNA:SNP:cds: p.D398N(human)		 RGD
ClinVar		 PMID:19577767 PMID:20554942 PMID:23314339 PMID:27993330 RGD:150524359 RGD:150527848 RGD:150527849 NCBI chr 7:47,382,860...47,425,871
Ensembl chr 7:47,383,792...47,425,841 		JBrowse link
G CHRNB4 cholinergic receptor nicotinic beta 4 subunit ISO mRNA:increased expression:lung
DNA:hypomethylation:promoter:		 RGD PMID:20124469 PMID:22945651 RGD:150527851 RGD:151361154 NCBI chr 7:47,338,819...47,359,064 JBrowse link
G CLPTM1L CLPTM1 like susceptibility
no_association
ameliorates		 ISO CTD Direct Evidence: marker/mechanism
DNA:SNP::rs77518573(human)
DNA:SNP: :rs401681(human)
DNA:SNP::rs401681(human)
DNA:SNP:: rs31490(human)
mRNA:increased expression:lung
DNA:SNP:: rs4975616(human)		 CTD
RGD		 PMID:19955392 PMID:22675468 PMID:23738012 PMID:23908149 PMID:24366883 More... RGD:150530483 RGD:150530485 RGD:150530498 RGD:150530499 RGD:150530502 RGD:150530635 RGD:150537098 NCBI chr16:79,237,000...79,248,503
Ensembl chr16:79,237,061...79,248,500 		JBrowse link
G CMTR2 cap methyltransferase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr 6:14,325,869...14,334,043
Ensembl chr 6:14,323,981...14,334,008 		JBrowse link
G COL10A1 collagen type X alpha 1 chain disease_progression ISO mRNA:increased expression:lung RGD PMID:33324550 RGD:150429752 NCBI chr 1:81,766,829...81,773,818
Ensembl chr 1:81,765,859...81,773,818 		JBrowse link
G CREBBP CREB binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr 3:38,388,366...38,530,243
Ensembl chr 3:38,388,547...38,530,224 		JBrowse link
G CSF1R colony stimulating factor 1 receptor ISO protein:increased expression:lung (human) RGD PMID:23702648 RGD:150524280 NCBI chr 2:151,102,138...151,130,311
Ensembl chr 2:151,102,147...151,147,633 		JBrowse link
G CSRP3 cysteine and glycine rich protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 2:40,219,288...40,240,614
Ensembl chr 2:40,215,353...40,240,616 		JBrowse link
G CTNNB1 catenin beta 1 ISO ClinVar Annotator: match by term: Lung adenocarcinoma
ClinVar Annotator: match by term: Adenocarcinoma of lung		 ClinVar PMID:10192393 PMID:25741868 PMID:26619011 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 exacerbates ISO protein:increased expression:lung (human)
mRNA:increased expression:lung (human)		 RGD PMID:19716197 PMID:30103827 RGD:152023735 RGD:152177480 NCBI chr15:15,663,652...15,666,706
Ensembl chr15:15,663,494...15,667,232 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 ISO protein:increased expression:lung (human) RGD PMID:19358281 RGD:152177688 NCBI chr 3:102,195,743...102,205,687
Ensembl chr 3:102,195,741...102,205,683 		JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 ameliorates ISO DNA:hypomethylation:promoter (human)
mRNA:decreased expression:lung (human)
human cell line in a mouse model		 RGD PMID:24736069 PMID:25519225 PMID:27793774 RGD:151361181 RGD:151665173 RGD:151665499 NCBI chr17:55,110,546...55,130,328
Ensembl chr17:55,110,590...55,130,363 		JBrowse link
G CYP2A19 cytochrome P450 family 2 subfamily A member 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18669584 NCBI chr 6:49,056,579...49,064,111
Ensembl chr 6:49,056,578...49,064,107 		JBrowse link
G DDR2 discoidin domain receptor tyrosine kinase 2 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 4:87,749,738...87,911,818
Ensembl chr 4:87,756,168...87,911,296 		JBrowse link
G DDX41 DEAD-box helicase 41 disease_progression ISO RGD PMID:20139980 RGD:152177521 NCBI chr 2:80,440,774...80,445,484
Ensembl chr 2:80,439,247...80,445,482 		JBrowse link
G DLL4 delta like canonical Notch ligand 4 treatment ISO RGD PMID:33628824 RGD:155663482 NCBI chr 1:130,376,720...130,386,411
Ensembl chr 1:130,376,721...130,386,411 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:21067377 PMID:21518476 PMID:22160010 PMID:22722925 PMID:22744846 More... NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta susceptibility ISO DNA:SNPs,haplotype:promoter:-283T >C,-579G>T(human) RGD PMID:15528220 RGD:9589086 NCBI chr17:36,345,715...36,386,076
Ensembl chr17:36,345,816...36,386,072 		JBrowse link
G DOK1 docking protein 1 disease_progression ISO RGD PMID:20139980 RGD:152177521 NCBI chr 3:68,494,516...68,497,374
Ensembl chr 3:68,494,520...68,497,407 		JBrowse link
G DOK2 docking protein 2 exacerbates
disease_progression		 ISO mRNA:decreased expression:lung (human) RGD PMID:20139980 PMID:24255704 PMID:30475228 RGD:152177492 RGD:152177493 RGD:152177521 NCBI chr14:6,176,487...6,180,895
Ensembl chr14:6,177,009...6,188,708 		JBrowse link
G DOT1L DOT1 like histone lysine methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr 2:76,339,452...76,401,974
Ensembl chr 2:76,339,470...76,401,965 		JBrowse link
G E2F1 E2F transcription factor 1 ISO mRNA:increased expression:lung RGD PMID:26695082 RGD:13464334 NCBI chr17:37,178,587...37,190,118
Ensembl chr17:37,178,599...37,189,883 		JBrowse link
G E2F3 E2F transcription factor 3 ISO RGD PMID:16938365 RGD:13464341 NCBI chr 7:15,793,519...15,870,213
Ensembl chr 7:15,794,178...15,870,204 		JBrowse link
G EEF2 eukaryotic translation elongation factor 2 exacerbates ISO protein:increased expression:lung (human) RGD PMID:21554491 RGD:153298904 NCBI chr 2:74,746,541...74,756,687
Ensembl chr 2:74,747,080...74,756,680 		JBrowse link
G EEF2K eukaryotic elongation factor 2 kinase ameliorates ISO Human cells in mouse model RGD PMID:30522114 RGD:153298964 NCBI chr 3:23,887,120...23,980,231
Ensembl chr 3:23,887,125...23,956,373 		JBrowse link
G EGF epidermal growth factor ISO DNA:polymorphism: :p.A61G (human) RGD PMID:26625757 RGD:11538684 NCBI chr 8:112,235,607...112,330,062
Ensembl chr 8:112,234,386...112,330,046 		JBrowse link
G EGFR epidermal growth factor receptor disease_progression ISO ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Adenocarcinoma of lung, somatic | ClinVar Annotator: match by term: Lung adenocarcinoma RGD
ClinVar		 PMID:11423618 PMID:15118073 PMID:15118125 PMID:15272417 PMID:15329413 More... RGD:126790475 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
G EHMT2 euchromatic histone lysine methyltransferase 2 disease_progression ISO RGD PMID:20940408 RGD:9589170 NCBI chr 7:23,977,683...23,992,673
Ensembl chr 7:23,977,683...23,992,697 		JBrowse link
G EIF2B1 eukaryotic translation initiation factor 2B subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr14:29,355,497...29,367,918
Ensembl chr14:29,332,233...29,367,918 		JBrowse link
G EIF2B4 eukaryotic translation initiation factor 2B subunit delta ISO CTD Direct Evidence: marker/mechanism CTD PMID:24366584 NCBI chr 3:111,781,661...111,786,377
Ensembl chr 3:111,781,648...111,786,372 		JBrowse link
G EIF2B5 eukaryotic translation initiation factor 2B subunit epsilon ISO CTD Direct Evidence: marker/mechanism CTD PMID:24366584 NCBI chr13:122,060,408...122,070,327
Ensembl chr13:122,060,473...122,070,304 		JBrowse link
G EIF3E eukaryotic translation initiation factor 3 subunit E ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 4:29,288,878...29,343,593
Ensembl chr 4:29,264,042...29,352,902 		JBrowse link
G EML4 EMAP like 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22980554 PMID:22999080 NCBI chr 3:98,005,809...98,155,876
Ensembl chr 3:98,005,812...98,155,846 		JBrowse link
G EMX2 empty spiracles homeobox 2 exacerbates ISO mRNA,protein:decreased expression:lung (human) RGD PMID:21726823 RGD:153323303 NCBI chr14:127,649,675...127,656,972
Ensembl chr14:127,650,688...127,655,706 		JBrowse link
G ENO1 enolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 PMID:27602772 NCBI chr 6:69,385,879...69,401,664
Ensembl chr 6:69,385,879...69,401,151 		JBrowse link
G EP300 E1A binding protein p300 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 disease_progression ISO ClinVar Annotator: match by term: Lung adenocarcinoma RGD
ClinVar		 PMID:15457249 PMID:15753357 PMID:16638863 PMID:18334834 PMID:22325357 More... RGD:126790475 NCBI chr12:22,591,621...22,621,384
Ensembl chr12:22,590,725...22,621,351 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 disease_progression ISO RGD PMID:26824984 RGD:126790475 NCBI chr 5:21,474,218...21,495,040
Ensembl chr 5:21,474,475...21,495,038 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 disease_progression ISO RGD PMID:26824984 RGD:126790475 NCBI chr15:113,966,573...115,096,984
Ensembl chr15:113,974,437...115,096,565 		JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:21327329 NCBI chr 6:51,783,537...51,808,898
Ensembl chr 6:51,783,478...51,798,984 		JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor ISO mRNA, protein:increased expression:lung (human) RGD PMID:31615563 RGD:155260344 NCBI chr14:89,998,125...90,075,911
Ensembl chr14:90,002,024...90,075,898 		JBrowse link
G ERCC6L ERCC excision repair 6 like, spindle assembly checkpoint helicase exacerbates ISO mRNA:increased expression:lung (human) RGD PMID:35150321 RGD:155260359 NCBI chr  X:58,087,216...58,117,942
Ensembl chr  X:58,087,169...58,117,947 		JBrowse link
G ERGIC3 ERGIC and golgi 3 disease_progression
ameliorates		 ISO mRNA,protein:increased expression:lung (human) RGD PMID:23374247 PMID:27588471 RGD:151708716 RGD:153323314 NCBI chr17:38,884,830...38,899,140
Ensembl chr17:38,885,117...38,899,138 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr14:39,687,028...39,695,748
Ensembl chr14:39,687,000...39,695,752 		JBrowse link
G ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 ameliorates ISO RGD PMID:33573689 RGD:155791670 NCBI chr14:11,495,297...11,532,898 JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit disease_progression ISO RGD PMID:24097870 RGD:126781716 NCBI chr 9:109,384,976...109,450,943
Ensembl chr 9:109,385,015...109,450,941 		JBrowse link
G FAS Fas cell surface death receptor ISO mRNA:decreased expression:lung (human) RGD PMID:29254206 RGD:151665107 NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716 		JBrowse link
G FASN fatty acid synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr12:922,405...937,560
Ensembl chr12:920,509...937,561 		JBrowse link
G FBL fibrillarin ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 6:48,314,782...48,326,433
Ensembl chr 6:48,314,783...48,326,436 		JBrowse link
G FES FES proto-oncogene, tyrosine kinase treatment ISO human cells in a mouse model RGD PMID:31573955 RGD:153323295 NCBI chr 7:53,472,947...53,485,084
Ensembl chr 7:53,472,947...53,485,082 		JBrowse link
G FGF10 fibroblast growth factor 10 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr16:28,695,465...28,779,953
Ensembl chr16:28,695,470...28,777,509 		JBrowse link
G FGF18 fibroblast growth factor 18 ISO mRNA:decreased expression:lung (human) RGD PMID:19296538 RGD:150429981 NCBI chr16:52,724,867...52,760,246
Ensembl chr16:52,725,356...52,759,791 		JBrowse link
G FGF9 fibroblast growth factor 9 disease_progression ISO protein:increased expression:lung (human)
mRNA:decreased expression:lung (human)		 RGD PMID:19296538 PMID:19358281 PMID:20464547 RGD:150429981 RGD:152177688 RGD:152975620 NCBI chr11:1,554,648...1,581,938
Ensembl chr11:1,554,763...1,582,408 		JBrowse link
G FGFR4 fibroblast growth factor receptor 4 disease_progression
exacerbates		 ISO human cells in mouse model
DNA:SNP:exon 9: p.G388R (rs351855)(human)
DNA:SNP:exon 9: p.G388R (human)		 RGD PMID:16061909 PMID:19296538 PMID:29402970 RGD:150429976 RGD:150429981 RGD:150429984 NCBI chr 2:80,841,536...80,853,791
Ensembl chr 2:80,841,536...80,853,796 		JBrowse link
G FKBP11 FKBP prolyl isomerase 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 5:14,959,305...14,964,231
Ensembl chr 5:14,961,518...14,963,546 		JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr11:5,620,698...5,797,095
Ensembl chr11:5,621,212...5,795,264 		JBrowse link
G FOXA1 forkhead box A1 ISO mRNA:increased expression:lung
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:12234996 PMID:29072684 PMID:34254728 RGD:151665758 RGD:151665822 NCBI chr 7:62,471,233...62,479,638
Ensembl chr 7:62,471,249...62,479,220 		JBrowse link
G FOXO3 forkhead box O3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19380174 NCBI chr 1:74,626,673...74,760,323
Ensembl chr 1:74,628,218...74,760,325 		JBrowse link
G FOXP1 forkhead box P1 ISO mRNA:decreased expression:lung (rat) RGD PMID:16023287 RGD:11561933 NCBI chr13:52,346,844...52,974,358
Ensembl chr13:52,348,234...52,876,892 		JBrowse link
G FOXP2 forkhead box P2 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr18:31,335,102...31,890,523
Ensembl chr18:31,335,264...31,888,845 		JBrowse link
G FOXP4 forkhead box P4 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 7:36,760,643...36,793,620
Ensembl chr 7:36,742,752...36,793,619 		JBrowse link
G FRZB frizzled related protein severity ISO mRNA:decreased expression:lung (human) RGD PMID:27623992 RGD:32716395 NCBI chr15:88,332,856...88,377,275
Ensembl chr15:88,332,860...88,377,247 		JBrowse link
G FUBP1 far upstream element binding protein 1 ISO mRNA:decreased expression:lung (human) RGD PMID:32481602 RGD:151361197 NCBI chr 6:135,281,474...135,319,055
Ensembl chr 6:135,281,521...135,318,714 		JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991 		JBrowse link
G GAR1 GAR1 ribonucleoprotein ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 8:112,401,114...112,414,277
Ensembl chr 8:112,400,005...112,414,033 		JBrowse link
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr13:197,130,898...197,158,797
Ensembl chr13:197,130,904...197,161,891 		JBrowse link
G GJB2 gap junction protein beta 2 ISO DNA, mRNA:hypermethylation, decreased expression:lung RGD PMID:16637067 RGD:11568669 NCBI chr11:774,090...781,252
Ensembl chr11:775,166...775,846 		JBrowse link
G GNG11 G protein subunit gamma 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24366584 NCBI chr 9:73,721,327...73,726,229
Ensembl chr 9:73,721,322...73,726,222 		JBrowse link
G GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 1:182,404,460...182,423,453
Ensembl chr 1:182,407,229...182,423,441 		JBrowse link
G GOLM1 golgi membrane protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr10:29,117,578...29,219,024
Ensembl chr10:29,118,314...29,219,018 		JBrowse link
G GPI glucose-6-phosphate isomerase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 6:44,038,374...44,069,331
Ensembl chr 6:44,038,357...44,069,328 		JBrowse link
G GPX3 glutathione peroxidase 3 ISO mRNA:decreased expression:lung (human) RGD PMID:23374247 RGD:151708716 NCBI chr16:71,980,467...71,989,011
Ensembl chr16:71,980,475...71,989,026 		JBrowse link
G GRWD1 glutamate rich WD repeat containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 6:53,849,673...53,856,229
Ensembl chr 6:53,849,852...53,859,385 		JBrowse link
G H1-10 H1.10 linker histone ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr13:71,760,464...71,762,035
Ensembl chr13:71,760,467...71,761,839 		JBrowse link
G HELLS helicase, lymphoid specific ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr14:105,923,727...105,967,003
Ensembl chr14:105,924,536...105,955,430 		JBrowse link
G HK1 hexokinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr14:72,383,328...72,460,927
Ensembl chr14:72,351,246...72,460,924 		JBrowse link
G HK2 hexokinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 3:68,155,656...68,231,187
Ensembl chr 3:68,153,835...68,231,615 		JBrowse link
G HMGB2 high mobility group box 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24366584 PMID:27602772 NCBI chr14:16,709,966...16,712,288
Ensembl chr14:16,710,047...16,717,101 		JBrowse link
G HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 5:19,485,033...19,491,418
Ensembl chr 5:19,485,096...19,491,417 		JBrowse link
G HOXB7 homeobox B7 severity ISO protein:increased expression:lung epithelium (human) RGD PMID:22911672 RGD:10402176 NCBI chr12:24,861,165...24,864,675
Ensembl chr12:24,861,174...24,864,620 		JBrowse link
G HRAS HRas proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:1904555 PMID:3510078 PMID:11150980 PMID:12835555 PMID:16155195 More... NCBI chr 2:299,662...302,539
Ensembl chr 2:299,660...302,501 		JBrowse link
G HSD17B10 hydroxysteroid 17-beta dehydrogenase 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr  X:46,218,540...46,220,942
Ensembl chr  X:46,218,548...46,220,883 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO mRNA:increased expression:lung (human) RGD PMID:23374247 RGD:151708716 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 3:10,038,074...10,039,441
Ensembl chr 3:10,037,949...10,039,704 		JBrowse link
G HTR4 5-hydroxytryptamine receptor 4 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 2:149,768,295...149,813,801
Ensembl chr 2:149,731,034...149,912,495 		JBrowse link
G HTRA1 HtrA serine peptidase 1 disease_progression ISO human cells in mouse model RGD PMID:24356998 RGD:152975621 NCBI chr14:132,043,044...132,103,590
Ensembl chr14:132,041,934...132,103,595 		JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 disease_progression ISO mRNA:increased expression:lung (human)
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma
protein:increased expression:blood plasma (human)		 RGD
ClinVar		 PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20946881 More... RGD:149735539 RGD:149735540 NCBI chr15:111,341,153...111,362,330
Ensembl chr15:111,341,153...111,362,296 		JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 severity ISO protein:increased expression:lung (human)
protein:increased expression:blood serum (human)		 RGD PMID:29465809 PMID:30128035 RGD:149735564 RGD:149735567 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,609...55,675,554 		JBrowse link
G IGF2R insulin like growth factor 2 receptor ISO mRNA:deletions: :c.3698_4902del, c.3366_4902del, c.3817_4697del (rat) RGD PMID:12503077 RGD:1298968 NCBI chr 1:7,369,485...7,472,480
Ensembl chr 1:7,368,103...7,472,548 		JBrowse link
G IKZF1 IKAROS family zinc finger 1 exacerbates
ameliorates		 ISO protein:increased expression:lung (human)
mRNA:increased expression:lung (human)		 RGD PMID:32787735 PMID:33738286 RGD:150540324 RGD:151347632 NCBI chr 9:136,372,202...136,464,942
Ensembl chr 9:136,372,725...136,464,940 		JBrowse link
G IL1R2 interleukin 1 receptor type 2 disease_progression
severity		 ISO mRNA:altered expression:lung (human)
mRNA:increased expression:lung (human)		 RGD PMID:29942094 PMID:31921619 RGD:152998982 RGD:152998998 NCBI chr 3:52,367,434...52,406,393
Ensembl chr 3:52,367,437...52,406,334 		JBrowse link
G IMPDH2 inosine monophosphate dehydrogenase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr13:31,658,642...31,663,660
Ensembl chr13:31,658,650...31,663,552 		JBrowse link
G IPO4 importin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 7:75,109,844...75,118,739
Ensembl chr 7:75,110,082...75,118,733 		JBrowse link
G IPO5 importin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr11:67,019,299...67,059,375
Ensembl chr11:67,004,109...67,060,551 		JBrowse link
G IQSEC1 IQ motif and Sec7 domain ArfGEF 1 disease_progression ISO RGD PMID:24902879 RGD:153350085 NCBI chr13:71,203,967...71,366,685
Ensembl chr13:71,031,001...71,366,684 		JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 ISO mRNA:increased expression:lung (human) RGD PMID:21278795 RGD:36049796 NCBI chr 5:30,524,704...30,601,067
Ensembl chr 5:30,526,793...30,609,921 		JBrowse link
G IREB2 iron responsive element binding protein 2 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 7:47,481,539...47,529,199
Ensembl chr 7:47,478,706...47,529,242 		JBrowse link
G JAK2 Janus kinase 2 treatment ISO human cells in mouse model RGD PMID:27025877 RGD:11574134 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148 		JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:24366584 NCBI chr 2:66,214,086...66,219,435
Ensembl chr 2:66,214,138...66,217,002 		JBrowse link
G KCNJ4 potassium inwardly rectifying channel subfamily J member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30512237 NCBI chr 5:9,526,399...9,549,290
Ensembl chr 5:9,547,177...9,548,520 		JBrowse link
G KLF5 KLF transcription factor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr11:45,370,009...45,386,673
Ensembl chr11:45,369,810...45,388,314 		JBrowse link
G KMT2C lysine methyltransferase 2C disease_progression
onset		 ISO RGD PMID:30821106 PMID:32867667 RGD:151356760 RGD:151356761 NCBI chr18:4,993,213...5,279,668
Ensembl chr18:4,993,227...5,278,723 		JBrowse link
G KPNA2 karyopherin subunit alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr12:14,283,092...14,296,749
Ensembl chr12:14,283,087...14,296,746 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Adenocarcinoma of lung
ClinVar Annotator: match by term: Lung adenocarcinoma		 ClinVar PMID:2278970 PMID:3122217 PMID:6320174 PMID:11745231 PMID:12460918 More... NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358 		JBrowse link
G LDHA lactate dehydrogenase A ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715 		JBrowse link
G LECT2 leukocyte cell derived chemotaxin 2 ameliorates ISO human cells in mouse model RGD PMID:30453282 RGD:153323337 NCBI chr 2:138,109,537...138,120,285
Ensembl chr 2:138,109,351...138,124,464 		JBrowse link
G LMNA lamin A/C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 4:93,899,019...93,927,255
Ensembl chr 4:93,899,019...93,926,320 		JBrowse link
G LMNB1 lamin B1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 2:129,807,228...129,862,211
Ensembl chr 2:129,807,318...129,872,270 		JBrowse link
G LRP1B LDL receptor related protein 1B disease_progression ISO DNA:mutations:multiple: (human) RGD PMID:18948947 RGD:11064706 NCBI chr15:9,612,805...11,499,969
Ensembl chr15:9,613,238...11,499,530 		JBrowse link
G LRRC56 leucine rich repeat containing 56 ISO ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:1904555 PMID:3510078 PMID:11150980 PMID:12835555 PMID:16155195 More... NCBI chr 2:303,836...323,701
Ensembl chr 2:304,430...323,699 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 ISO ClinVar Annotator: match by term: Adenocarcinoma of lung
mRNA:increased expression:lung (human)
CTD Direct Evidence: marker/mechanism		 ClinVar
RGD
CTD		 PMID:22135231 PMID:26619011 PMID:29254206 RGD:151665107 NCBI chr 1:164,381,892...164,469,313
Ensembl chr 1:164,381,845...164,471,226 		JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 severity ISO RGD PMID:12231543 PMID:21896780 RGD:150429783 RGD:150429821 NCBI chr12:56,402,029...56,516,217
Ensembl chr12:56,402,075...56,516,238 		JBrowse link
G MAP2K7 mitogen-activated protein kinase kinase 7 exacerbates ISO human gene in a mouse model RGD PMID:34236045 RGD:155230828 NCBI chr 2:71,299,010...71,308,432
Ensembl chr 2:71,298,325...71,308,124 		JBrowse link
G MAP3K8 mitogen-activated protein kinase kinase kinase 8 exacerbates ISO RGD PMID:23533274 RGD:151356978 NCBI chr10:40,714,004...40,746,390
Ensembl chr10:40,713,847...40,742,462 		JBrowse link
G MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 exacerbates
ameliorates		 ISO protein:increased expression:lung (human)
mRNA, protein:increased expression:lung (human)
human cell line in a mouse model		 RGD PMID:22824148 PMID:28306189 PMID:33510968 RGD:151347677 RGD:151347678 RGD:151347681 NCBI chr 3:52,483,028...52,649,480
Ensembl chr 3:52,484,274...52,649,410 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 exacerbates ISO mRNA:increased expression:lung (human) RGD PMID:31969449 RGD:151665505 NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031 		JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member severity
treatment		 ISO mRNA:increased expression:lung (human)
human cells in mouse model		 RGD PMID:31200834 RGD:151356911 NCBI chr 4:98,562,092...98,567,014
Ensembl chr 4:98,534,812...98,567,006 		JBrowse link
G MEOX1 mesenchyme homeobox 1 ISO CTD Direct Evidence: therapeutic CTD PMID:34837450 NCBI chr12:19,431,397...19,452,430
Ensembl chr12:19,431,420...19,451,993 		JBrowse link
G MIER3 MIER family member 3 ameliorates ISO RGD PMID:35117188 RGD:407571696 NCBI chr16:35,990,468...36,025,424
Ensembl chr16:35,990,469...36,025,436 		JBrowse link
G MIR127 microRNA mir-127 treatment ISO Human cells in mouse model RGD PMID:27869168 RGD:152995353 NCBI chr 7:121,709,636...121,709,715
Ensembl chr 7:121,709,640...121,709,720 		JBrowse link
G MIR20A microRNA mir-20a ISO RGD PMID:26560875 RGD:11572141 NCBI chr11:60,735,109...60,735,179
Ensembl chr11:60,735,099...60,735,196 		JBrowse link
G MIR21 microRNA mir-21 disease_progression ISO RNA:increased expression:lung (human)
miRNA:increased expression:sputum (human)		 RGD PMID:27777637 PMID:29892003 RGD:152998892 RGD:152998954 NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358 		JBrowse link
G MIR31 microRNA mir-31 severity
disease_progression		 ISO RNA:increased expression:lung (human) RGD PMID:23946296 PMID:26657862 PMID:27215092 PMID:29367106 RGD:11250998 RGD:11343268 RGD:152998944 RGD:152998945 NCBI chr 1:201,198,732...201,198,809
Ensembl chr 1:201,198,732...201,198,809 		JBrowse link
G MIR432 microRNA mir-432 disease_progression ISO mRNA:decreased expression:lung (human)
human cells in mouse model		 RGD PMID:26942465 RGD:152999419 NCBI chr 7:121,711,137...121,711,216
Ensembl chr 7:121,711,137...121,711,216 		JBrowse link
G MKI67 marker of proliferation Ki-67 disease_progression ISO protein:altered expression:lung (human) RGD PMID:26942465 RGD:152999419 NCBI chr14:137,266,622...137,296,312 JBrowse link
G MLH1 mutL homolog 1 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr13:21,791,276...21,877,789
Ensembl chr13:21,791,203...21,877,757 		JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 9:26,572,352...26,634,596
Ensembl chr 9:26,572,361...26,634,567 		JBrowse link
G MRPL12 mitochondrial ribosomal protein L12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr12:1,200,458...1,203,817
Ensembl chr12:1,200,461...1,203,822 		JBrowse link
G MRPS5 mitochondrial ribosomal protein S5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 3:46,137,566...46,169,403
Ensembl chr 3:46,137,509...46,169,807 		JBrowse link
G MS4A1 membrane spanning 4-domains A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22514692 NCBI chr 2:11,216,238...11,229,060
Ensembl chr 2:11,215,901...11,222,914 		JBrowse link
G MSH2 mutS homolog 2 no_association ISO DNA:polymorphisms:introns:IVS10+12A>G, IVS12-6T>C (human)
DNA:polymorphisms:promoter, intron:-118T>C, IVS1+9G>C (human)		 RGD PMID:16614121 RGD:11065547 NCBI chr 3:93,082,958...93,163,556
Ensembl chr 3:93,081,219...93,163,585 		JBrowse link
G MSH3 mutS homolog 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21327329 NCBI chr 2:89,255,647...89,456,102
Ensembl chr 2:89,250,003...89,453,936 		JBrowse link
G MSH6 mutS homolog 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21327329 NCBI chr 3:92,792,590...92,814,154
Ensembl chr 3:92,785,664...92,814,238 		JBrowse link
G MUC1 mucin 1, cell surface associated ISO mRNA:increased expression:lung RGD PMID:8694545 RGD:5131260 NCBI chr 4:94,626,317...94,631,194 JBrowse link
G MUC4 mucin 4, cell surface associated disease_progression ISO protein:increased expression:trachea RGD PMID:17126950 RGD:5131208 NCBI chr13:134,192,412...134,248,435 JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 2:757,897...790,321 JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor ISO CTD Direct Evidence: marker/mechanism
human cell line in mouse model		 CTD
RGD		 PMID:20033209 PMID:26656844 PMID:27602772 RGD:7207787 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor treatment
ameliorates		 ISO mouse cell line in a mouse model RGD PMID:30712876 PMID:32140881 RGD:150520172 RGD:150540309 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109 		JBrowse link
G NAA10 N-alpha-acetyltransferase 10, NatA catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr  X:124,658,429...124,662,744
Ensembl chr  X:124,658,158...124,662,702 		JBrowse link
G NAIP NLR family apoptosis inhibitory protein ameliorates ISO mRNA:increased expression:lung (human) RGD PMID:31964418 RGD:153344516 NCBI chr16:47,700,869...47,710,036 JBrowse link
G NCAPG non-SMC condensin I complex subunit G ISO CTD Direct Evidence: marker/mechanism CTD PMID:34419073 NCBI chr 8:12,759,225...12,807,164
Ensembl chr 8:12,759,641...12,807,163 		JBrowse link
G NCL nucleolin ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr15:132,163,453...132,174,214
Ensembl chr15:132,162,516...132,174,172 		JBrowse link
G NKX2-1 NK2 homeobox 1 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 7:63,487,200...63,491,580
Ensembl chr 7:63,487,807...63,491,575 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228 		JBrowse link
G NOP56 NOP56 ribonucleoprotein ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr17:32,960,099...32,965,396
Ensembl chr17:32,960,102...32,965,370 		JBrowse link
G NOP58 NOP58 ribonucleoprotein ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr15:105,893,589...105,930,458
Ensembl chr15:105,893,637...105,930,459 		JBrowse link
G NOTCH1 notch receptor 1 treatment ISO RGD PMID:33628824 RGD:155663482
G NPM1 nucleophosmin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr16:52,767,263...52,781,862
Ensembl chr16:52,765,298...52,781,771 		JBrowse link
G NPM3 nucleophosmin/nucleoplasmin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr14:112,819,390...112,822,244
Ensembl chr14:112,819,393...112,821,367 		JBrowse link
G NUDT21 nudix hydrolase 21 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 6:29,339,893...29,359,596
Ensembl chr 6:29,339,841...29,363,312 		JBrowse link
G NUF2 NUF2 component of NDC80 kinetochore complex disease_progression ISO RGD PMID:32226507 RGD:28912743 NCBI chr 4:87,162,873...87,194,193
Ensembl chr 4:87,162,818...87,194,170 		JBrowse link
G OGG1 8-oxoguanine DNA glycosylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23951099 NCBI chr13:66,038,669...66,045,478 JBrowse link
G PABPC4 poly(A) binding protein cytoplasmic 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 6:95,382,295...95,399,452
Ensembl chr 6:95,382,302...95,399,080 		JBrowse link
G PACRG parkin coregulated ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:12719539 NCBI chr 1:4,964,686...5,465,258
Ensembl chr 1:4,967,224...5,465,064 		JBrowse link
G PCBD1 pterin-4 alpha-carbinolamine dehydratase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr14:73,769,339...73,807,278
Ensembl chr14:73,800,765...73,807,281 		JBrowse link
G PIGN phosphatidylinositol glycan anchor biosynthesis class N ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 1:159,317,734...159,417,335
Ensembl chr 1:159,317,734...159,417,327 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 More... NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,274,587 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO mRNA:decreased expression:lung RGD PMID:26695082 RGD:13464334 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609 		JBrowse link
G PITX2 paired like homeodomain 2 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 8:111,697,364...111,723,295
Ensembl chr 8:111,698,757...111,723,298 		JBrowse link
G PLCG1 phospholipase C gamma 1 exacerbates ISO protein:decreased expression:lung (human) RGD PMID:33077911 RGD:151356960 NCBI chr17:43,810,003...43,844,553
Ensembl chr17:43,810,048...43,844,554 		JBrowse link
G PLOD2 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 disease_progression ISO RGD PMID:29072684 RGD:151665822 NCBI chr13:86,402,673...86,513,167
Ensembl chr13:86,401,244...86,513,105 		JBrowse link
G POLD1 DNA polymerase delta 1, catalytic subunit exacerbates ISO protein:increased expression:lung (human) RGD PMID:33442399 RGD:153323317 NCBI chr 6:55,247,799...55,272,087
Ensembl chr 6:55,247,880...55,272,085 		JBrowse link
G POLR1D RNA polymerase I and III subunit D ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr11:5,044,274...5,045,921
Ensembl chr11:5,044,329...5,089,766 		JBrowse link
G PPAN peter pan homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 2:68,958,906...68,962,657
Ensembl chr 2:68,958,906...68,962,657 		JBrowse link
G PPP3CA protein phosphatase 3 catalytic subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr 8:119,429,181...119,754,615
Ensembl chr 8:119,428,779...119,753,105 		JBrowse link
G PRAME PRAME nuclear receptor transcriptional regulator ISO mRNA:decreased expression:lung (human) RGD PMID:27241212 RGD:11535020 NCBI chr14:48,901,097...48,906,855
Ensembl chr14:48,899,343...48,911,231 		JBrowse link
G PRDM1 PR/SET domain 1 exacerbates ISO RGD PMID:28378641 RGD:150530469 NCBI chr 1:72,309,096...72,335,474
Ensembl chr 1:72,311,880...72,335,466 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:10072423 PMID:12719539 PMID:20301651 PMID:22956510 PMID:25741868 More... NCBI chr 1:5,698,508...6,731,132
Ensembl chr 1:5,465,312...6,730,872 		JBrowse link
G PSAT1 phosphoserine aminotransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 1:231,142,673...231,172,364
Ensembl chr 1:231,142,625...231,172,360 		JBrowse link
G PTCH1 patched 1 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 PMID:28492532 NCBI chr10:26,627,165...26,703,225
Ensembl chr10:26,627,425...26,703,223 		JBrowse link
G PTEN phosphatase and tensin homolog ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr14:99,929,590...100,021,619 JBrowse link
G PTPN13 protein tyrosine phosphatase non-receptor type 13 exacerbates
susceptibility		 ISO mRNA,protein:decreased expression:lung
DNA:missense mutations:cds:p.I1522M, p.Y2081D (human)		 RGD PMID:19672627 PMID:22245727 PMID:33536603 RGD:152176663 RGD:152176665 RGD:152975626 NCBI chr 8:132,035,170...132,200,425
Ensembl chr 8:132,035,151...132,249,411 		JBrowse link
G PTPRB protein tyrosine phosphatase receptor type B disease_progression ISO mRNA:decreased expression:lung (human)
mRNA:altered expression:lung (human)		 RGD PMID:7981622 PMID:29254206 RGD:151665107 RGD:151665112 NCBI chr 5:34,656,460...34,794,838
Ensembl chr 5:34,659,964...34,794,289 		JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J susceptibility ISO DNA:missense mutations:cds:p.R326Q, p.Q276P (human) RGD PMID:19672627 RGD:152176665 NCBI chr 2:14,548,489...14,724,823
Ensembl chr 2:14,548,428...14,724,474 		JBrowse link
G RAC1 Rac family small GTPase 1 exacerbates
ameliorates		 ISO mRNA:increased expression:lung (human) RGD PMID:31779616 PMID:32366477 RGD:152998910 RGD:153345550 NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase ISO ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:1760348 PMID:8601312 PMID:10064593 PMID:12077328 PMID:17603482 More... NCBI chr13:68,581,128...68,657,911
Ensembl chr13:68,580,812...68,657,829 		JBrowse link
G RANGRF RAN guanine nucleotide release factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr12:53,484,584...53,486,716
Ensembl chr12:53,485,265...53,486,713 		JBrowse link
G RARB retinoic acid receptor beta ISO DNA:hypomethylation:lung RGD PMID:26695082 RGD:13464334 NCBI chr13:12,336,387...12,507,688
Ensembl chr13:12,336,972...12,507,680 		JBrowse link
G RASA1 RAS p21 protein activator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr 2:94,879,615...94,992,725
Ensembl chr 2:94,878,911...94,993,450 		JBrowse link
G RB1 RB transcriptional corepressor 1 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr11:19,186,754...19,317,642
Ensembl chr11:19,186,761...19,317,690 		JBrowse link
G RBM10 RNA binding motif protein 10 ISO DNA:missense mutations, protein-truncating variants: :multiple
mRNA, protein:decreased expression:lung		 RGD PMID:22980975 PMID:29085465 PMID:30955253 RGD:11097386 RGD:151356983 RGD:151356984 NCBI chr  X:41,773,232...41,803,656
Ensembl chr  X:41,773,232...41,803,653 		JBrowse link
G RCL1 RNA terminal phosphate cyclase like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 1:217,142,965...217,204,960
Ensembl chr 1:217,142,966...217,204,965 		JBrowse link
G RFC4 replication factor C subunit 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr13:124,589,292...124,604,421
Ensembl chr13:124,589,295...124,604,426 		JBrowse link
G RIN3 Ras and Rab interactor 3 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 7:114,035,137...114,166,548
Ensembl chr 7:114,035,353...114,166,539 		JBrowse link
G RNASEH2A ribonuclease H2 subunit A ISO CTD Direct Evidence: marker/mechanism CTD PMID:34254728 NCBI chr 2:66,192,785...66,208,417
Ensembl chr 2:66,193,197...66,207,697 		JBrowse link
G RNF43 ring finger protein 43 severity ISO human cells in a mouse model RGD PMID:31286874 RGD:151361222 NCBI chr12:34,631,574...34,695,021
Ensembl chr12:34,635,228...34,694,378 		JBrowse link
G ROS1 ROS proto-oncogene 1, receptor tyrosine kinase ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 1:44,409,877...44,535,784
Ensembl chr 1:44,410,351...44,534,874 		JBrowse link
G RPL10A ribosomal protein L10a ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 7:31,327,763...31,330,624
Ensembl chr 7:31,327,440...31,333,638 		JBrowse link
G RPL13A ribosomal protein L13a ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 6:54,551,772...54,568,752
Ensembl chr 6:54,551,533...54,561,489 		JBrowse link
G RPL27A ribosomal protein L27a ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 9:708,531...712,410
Ensembl chr 9:707,693...711,219 		JBrowse link
G RPSA ribosomal protein SA ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr13:24,072,551...24,081,536
Ensembl chr13:24,072,527...24,081,541 		JBrowse link
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 9:6,026,151...6,065,211
Ensembl chr 9:6,025,073...6,065,143 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 3:126,357,198...126,367,145
Ensembl chr 3:126,347,819...126,365,644 		JBrowse link
G RRS1 ribosome biogenesis regulator 1 homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 4:68,285,803...68,288,213
Ensembl chr 4:68,285,803...68,288,195 		JBrowse link
G RUNX1 RUNX family transcription factor 1 ISO RGD PMID:28926105 RGD:126779571 NCBI chr13:198,371,835...198,635,648
Ensembl chr13:198,371,837...198,638,189 		JBrowse link
G SATB1 SATB homeobox 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr13:5,315,985...5,410,686
Ensembl chr13:5,314,148...5,417,610 		JBrowse link
G SDC1 syndecan 1 ISO mRNA:increased expression:lung (human) RGD PMID:23374247 RGD:151708716 NCBI chr 3:117,987,585...118,011,886
Ensembl chr 3:117,987,557...118,011,884 		JBrowse link
G SERPINA3-2 alpha-1-antichymotrypsin 2 ISO protein:increased expression:cytoplasm RGD PMID:8620411 RGD:5147446 NCBI chr 7:115,978,453...115,987,392
Ensembl chr 7:115,976,397...115,987,453 		JBrowse link
G SETD2 SET domain containing 2, histone lysine methyltransferase ameliorates
exacerbates
severity		 ISO human cells and genes in mouse model
DNA:mutations:multiple (human)		 RGD PMID:27687306 PMID:28202515 PMID:33223508 PMID:33707235 RGD:126848875 RGD:150429633 RGD:150429648 RGD:150429649 NCBI chr13:29,884,708...29,996,285
Ensembl chr13:29,884,719...29,996,359 		JBrowse link
G SFN stratifin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 6:84,188,521...84,189,824
Ensembl chr 6:84,188,445...84,189,827 		JBrowse link
G SFTPC surfactant protein C ISO CTD Direct Evidence: marker/mechanism CTD PMID:25851810 NCBI chr14:6,440,309...6,443,104
Ensembl chr14:6,440,309...6,443,095 		JBrowse link
G SFXN1 sideroflexin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 2:82,025,799...82,057,629
Ensembl chr 2:82,025,820...82,057,564 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr12:60,414,421...60,435,451
Ensembl chr12:60,416,463...60,435,450 		JBrowse link
G SLC15A2 solute carrier family 15 member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr13:138,595,942...138,634,473
Ensembl chr13:138,595,973...138,632,675 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr13:207,986,094...208,007,855
Ensembl chr13:207,986,098...208,007,675 		JBrowse link
G SLC1A5 solute carrier family 1 member 5 disease_progression ISO RGD PMID:26279756 RGD:151361150 NCBI chr 6:52,647,432...52,661,464
Ensembl chr 6:52,647,438...52,661,459 		JBrowse link
G SLC22A18 solute carrier family 22 member 18 disease_progression ISO mRNA:increased expression:lung (human)
ClinVar Annotator: match by term: Lung adenocarcinoma		 RGD
ClinVar		 PMID:27993330 PMID:32726996 RGD:150557423 NCBI chr 2:2,032,370...2,055,756
Ensembl chr 2:2,028,396...2,055,750 		JBrowse link
G SLC3A2 solute carrier family 3 member 2 disease_progression ISO RGD PMID:19171406 RGD:151361151 NCBI chr 2:8,892,071...8,919,070
Ensembl chr 2:8,892,089...8,919,072 		JBrowse link
G SLC4A4 solute carrier family 4 member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 8:67,768,955...68,177,213
Ensembl chr 8:67,706,874...68,177,212 		JBrowse link
G SLC4A7 solute carrier family 4 member 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr13:13,933,552...14,043,108
Ensembl chr13:13,933,711...14,043,058 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 disease_progression ISO RGD PMID:19171406 PMID:26279756 RGD:151361150 RGD:151361151 NCBI chr 6:1,545,940...1,574,298
Ensembl chr 6:1,545,944...1,574,285 		JBrowse link
G SMAD4 SMAD family member 4 ISO ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:6604412 PMID:8898652 PMID:9214508 PMID:9285566 PMID:9582123 More... NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,589,850...100,628,029 		JBrowse link
G SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr13:30,409,979...30,576,270
Ensembl chr13:30,409,983...30,576,327 		JBrowse link
G SNRPB small nuclear ribonucleoprotein polypeptides B and B1 severity ISO mRNA:increased expression:lung (human) RGD PMID:22876301 RGD:10768834 NCBI chr17:33,072,104...33,094,847
Ensembl chr17:33,080,407...33,094,602 		JBrowse link
G SNRPE small nuclear ribonucleoprotein polypeptide E severity ISO mRNA:increased expression:lung (human) RGD PMID:22876301 RGD:10768834 NCBI chr 9:64,560,544...64,567,007
Ensembl chr 9:64,560,523...64,567,007 		JBrowse link
G SNRPG small nuclear ribonucleoprotein polypeptide G ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 3:72,198,722...72,208,053
Ensembl chr 3:72,198,756...72,208,865 		JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr 3:101,209,568...101,366,057
Ensembl chr 3:101,209,641...101,362,723 		JBrowse link
G SOX2 SRY-box transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25184679 NCBI chr13:119,668,476...119,669,435
Ensembl chr13:119,668,476...119,669,435 		JBrowse link
G SOX30 SRY-box transcription factor 30 disease_progression ISO RGD PMID:26330328 RGD:11535423 NCBI chr16:65,642,107...65,677,693
Ensembl chr16:65,642,223...65,678,047 		JBrowse link
G SOX4 SRY-box transcription factor 4 ISO protein:increased expression:lung RGD PMID:29882245 RGD:153297792 NCBI chr 7:16,886,834...16,895,488
Ensembl chr 7:16,891,319...16,892,752 		JBrowse link
G SPOP speckle type BTB/POZ protein ameliorates ISO mRNA, protein:increased expression:lung (human)
human gene and cell line in mouse model		 RGD PMID:30607139 PMID:31105033 RGD:153298920 RGD:153298927 NCBI chr12:25,792,621...25,860,630
Ensembl chr12:25,792,630...25,860,595 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase severity ISO RGD PMID:12826049 RGD:150521546 NCBI chr17:40,470,970...40,524,862
Ensembl chr17:40,471,009...40,524,860 		JBrowse link
G SRM spermidine synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 6:71,246,895...71,253,534
Ensembl chr 6:71,246,876...71,253,508 		JBrowse link
G SRSF1 serine and arginine rich splicing factor 1 severity ISO RGD PMID:23071587 RGD:150429662 NCBI chr12:34,278,363...34,282,164
Ensembl chr12:34,272,956...34,282,162 		JBrowse link
G SRSF2 serine and arginine rich splicing factor 2 severity ISO RGD PMID:23071587 RGD:150429662 NCBI chr12:4,800,578...4,803,767
Ensembl chr12:4,800,624...4,801,675 		JBrowse link
G STK11 serine/threonine kinase 11 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 2:77,229,888...77,249,322
Ensembl chr 2:77,230,372...77,249,327 		JBrowse link
G STK39 serine/threonine kinase 39 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr15:74,441,019...74,757,851
Ensembl chr15:74,447,787...74,758,122 		JBrowse link
G STRBP spermatid perinuclear RNA binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 1:264,030,135...264,195,908
Ensembl chr 1:264,045,669...264,195,883 		JBrowse link
G SUCLG2 succinate-CoA ligase GDP-forming subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr13:48,650,851...49,090,521
Ensembl chr13:48,823,733...49,090,468 		JBrowse link
G TERT telomerase reverse transcriptase susceptibility ISO DNA:SNP:: rs2736100(human)
DNA:SNP::rs33963617(human)
DNA:SNPs:: rs2853669,rs2736108(human)
DNA:SNP: :rs2736098(human)		 RGD PMID:19955392 PMID:23738012 PMID:23908149 PMID:24761905 PMID:31935503 RGD:150530485 RGD:150530498 RGD:150530502 RGD:150530628 RGD:150530635 NCBI chr16:79,258,591...79,276,421
Ensembl chr16:79,258,591...79,276,421 		JBrowse link
G TF transferrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr13:74,930,655...74,970,599
Ensembl chr13:74,930,655...74,972,763 		JBrowse link
G TGFB2 transforming growth factor beta 2 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,539...8,390,341 		JBrowse link
G TIMM10 translocase of inner mitochondrial membrane 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 2:13,393,225...13,396,241
Ensembl chr 2:13,393,282...13,396,439 		JBrowse link
G TIMM8A translocase of inner mitochondrial membrane 8A ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr  X:82,978,128...82,981,038
Ensembl chr  X:82,974,270...82,980,769 		JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 ISO mRNA:decreased expression:lung (human) RGD PMID:23374247 RGD:151708716 NCBI chr 5:12,185,816...12,242,599
Ensembl chr 5:12,185,818...12,242,581 		JBrowse link
G TK1 thymidine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr12:3,785,997...3,794,824
Ensembl chr12:3,786,031...3,795,917 		JBrowse link
G TLR4 toll like receptor 4 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TNFSF10 TNF superfamily member 10 ISO CTD Direct Evidence: therapeutic CTD PMID:24345465 NCBI chr13:111,021,952...111,103,060
Ensembl chr13:110,983,298...111,038,324 		JBrowse link
G TOMM40 translocase of outer mitochondrial membrane 40 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 6:51,359,948...51,369,932
Ensembl chr 6:51,359,595...51,369,908 		JBrowse link
G TOP2A DNA topoisomerase II alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr12:22,001,300...22,028,452
Ensembl chr12:22,001,282...22,028,450 		JBrowse link
G TP53 tumor protein p53 ISO ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:1565144 PMID:1631137 PMID:2046748 PMID:7732013 PMID:8423216 More... NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
G TP63 tumor protein p63 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24880342 NCBI chr13:127,115,990...127,347,082
Ensembl chr13:127,116,105...127,347,068 		JBrowse link
G TPI1 triosephosphate isomerase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 5:63,839,473...63,842,853
Ensembl chr 5:63,838,506...63,843,134 		JBrowse link
G TRAF4 TNF receptor associated factor 4 ISO mRNA:increased expression:lung (human) RGD PMID:29254206 RGD:151665107 NCBI chr12:44,975,639...44,981,650
Ensembl chr12:44,975,632...44,987,104 		JBrowse link
G TTF1 transcription termination factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25851810 NCBI chr 1:272,180,488...272,212,504
Ensembl chr 1:272,180,498...272,212,478 		JBrowse link
G TTR transthyretin ISO mRNA,protein:increased expression:lung (human) RGD PMID:26943652 RGD:151665207 NCBI chr 6:115,496,338...115,503,974
Ensembl chr 6:115,496,326...115,503,977 		JBrowse link
G TYMS thymidylate synthetase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 6:105,642,730...105,660,279
Ensembl chr 6:105,642,381...105,660,578 		JBrowse link
G UBR5 ubiquitin protein ligase E3 component n-recognin 5 ameliorates ISO human cell line in a mouse model RGD PMID:32867711 RGD:151665200 NCBI chr 4:34,645,794...34,794,510
Ensembl chr 4:34,645,809...34,793,940 		JBrowse link
G UCK2 uridine-cytidine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 4:84,838,793...84,919,231
Ensembl chr 4:84,838,802...84,919,236 		JBrowse link
G VAV1 vav guanine nucleotide exchange factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr 2:72,327,433...72,391,649
Ensembl chr 2:72,326,716...72,391,648 		JBrowse link
G WRAP53 WD repeat containing antisense to TP53 severity ISO RGD PMID:28347242 RGD:21081522 NCBI chr12:52,954,674...52,968,371
Ensembl chr12:52,954,669...52,968,364 		JBrowse link
G XPC XPC complex subunit, DNA damage recognition and repair factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21327329 PMID:27777383 NCBI chr13:70,348,841...70,397,194
Ensembl chr13:70,348,864...70,397,772 		JBrowse link
G XPO1 exportin 1 exacerbates ISO mRNA:increased expression:lung (human)
circRNA:increased expression:lung (human)		 RGD PMID:23639940 PMID:33268793 RGD:151665799 RGD:151665801 NCBI chr 3:80,255,016...80,300,260
Ensembl chr 3:80,255,146...80,300,327 		JBrowse link
G XRCC1 X-ray repair cross complementing 1 severity
susceptibility		 ISO DNA:missense mutation:exon 10: p.R399Q (rs25487) (human)
DNA:missense mutation:cds: p.R399Q (human)		 RGD PMID:11104903 PMID:20003463 RGD:151347406 RGD:151347422 NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,689...50,425,729 		JBrowse link
G XRCC5 X-ray repair cross complementing 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr15:118,354,943...118,451,974
Ensembl chr15:118,354,796...118,451,960 		JBrowse link
G XRCC6 X-ray repair cross complementing 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 5:6,903,496...6,929,162
Ensembl chr 5:6,903,495...6,929,052 		JBrowse link
G ZFHX3 zinc finger homeobox 3 ameliorates ISO DNA:mutations:multiple (human) RGD PMID:32653938 RGD:151361163 NCBI chr 6:15,693,987...15,941,301
Ensembl chr 6:15,698,199...15,863,270 		JBrowse link
bronchiolo-alveolar adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALX4 ALX homeobox 4 ameliorates ISO RGD PMID:24037716 RGD:153344522 NCBI chr 2:18,070,726...18,085,685
Ensembl chr 2:18,037,401...18,085,683 		JBrowse link
G CCND1 cyclin D1 ISO protein:increased expression:lung RGD PMID:14674039 RGD:13434930 NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296 		JBrowse link
G DNMT1 DNA methyltransferase 1 disease_progression ISO RGD PMID:19484794 RGD:4140940 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844 		JBrowse link
G EGFR epidermal growth factor receptor ISO DNA:mutations:exons:
protein:increased expression:tumor (human)
DNA:snp:cds:p.T790M (human)		 RGD PMID:15737014 PMID:21419590 PMID:26059825 RGD:11075076 RGD:5131465 RGD:5131630 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
G EGR1 early growth response 1 ISO mRNA:decreased expression:tumor (human) RGD PMID:11948124 RGD:5131942 NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase ISO DNA:mutations:cds: RGD PMID:26059825 RGD:11075076 NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358 		JBrowse link
G LOC100739508 glutathione S-transferase P-like ISO DNA:hypermethylation:promoter (human) RGD PMID:19484794 RGD:4140940 NCBI chr 2:5,005,498...5,009,247 JBrowse link
G MIR130A microRNA mir-130a ISO CTD Direct Evidence: marker/mechanism CTD PMID:25926378 NCBI chr 2:13,296,695...13,296,773
Ensembl chr 2:13,296,695...13,296,773 		JBrowse link
G MIR144 microRNA mir-144 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25926378 NCBI chr12:45,088,958...45,089,033
Ensembl chr12:45,088,959...45,089,035 		JBrowse link
G MIR19A microRNA mir-19a ISO CTD Direct Evidence: marker/mechanism CTD PMID:25926378 NCBI chr11:60,734,939...60,735,020
Ensembl chr11:60,734,939...60,735,020 		JBrowse link
G MIR345-1 microRNA mir-345-1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25926378 NCBI chr 7:121,193,720...121,193,799
Ensembl chr 7:121,193,716...121,193,799 		JBrowse link
G MIR497 microRNA mir-497 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25926378 NCBI chr12:52,422,329...52,422,408
Ensembl chr12:52,422,330...52,422,411 		JBrowse link
G TP53 tumor protein p53 ISO DNA:mutations:exons: RGD PMID:26059825 RGD:11075076 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15430
    disease of cellular proliferation 7371
      cancer 5416
        cell type cancer 3615
          carcinoma 3123
            adenocarcinoma 1592
              lung adenocarcinoma 325
                bronchiolo-alveolar adenocarcinoma + 13
                lung acinar adenocarcinoma 0
                lung clear cell carcinoma 0
                lung mucinous cystadenocarcinoma 0
                lung occult adenocarcinoma 0
                lung papillary adenocarcinoma 0
                mucinous lung adenocarcinoma 0
                pulmonary adenocarcinoma in situ 0
                signet ring lung adenocarcinoma 0
                solid adenocarcinoma with mucin production 0
Path 2
Term Annotations click to browse term
  disease 15430
    disease of anatomical entity 15099
      respiratory system disease 4877
        thoracic disease 3749
          Thoracic Neoplasms 978
            Respiratory Tract Neoplasms 975
              Lung Neoplasms 952
                Bronchial Neoplasms 650
                  bronchus cancer 650
                    bronchus carcinoma 650
                      lung non-small cell carcinoma 612
                        lung adenocarcinoma 325
                          bronchiolo-alveolar adenocarcinoma + 13
                          lung acinar adenocarcinoma 0
                          lung clear cell carcinoma 0
                          lung mucinous cystadenocarcinoma 0
                          lung occult adenocarcinoma 0
                          lung papillary adenocarcinoma 0
                          mucinous lung adenocarcinoma 0
                          pulmonary adenocarcinoma in situ 0
                          signet ring lung adenocarcinoma 0
                          solid adenocarcinoma with mucin production 0
paths to the root