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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:lung adenocarcinoma
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Accession:DOID:3910 term browser browse the term
Definition:A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin. (DO)
Synonyms:exact_synonym: LUAD;   adenocarcinoma of lung;   bronchogenic lung adenocarcinoma;   non-small cell lung adenocarcinoma;   nonsmall cell adenocarcinoma;   pulmonary adenocarcinoma
 related_synonym: adenocarcinoma of lung, somatic
 primary_id: MESH:D000077192
 xref: EFO:0000571;   EFO:0005288;   GARD:5742;   NCI:C129299;   NCI:C27745;   NCI:C3512
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
lung adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, sub-family B member 1B EXP CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315 		JBrowse link
G Abce1 ATP-binding cassette, sub-family E member 1 severity ISO mRNA, protein:increased expression:lung (human) RGD PMID:18788636 RGD:11046260 NCBI chr 8:80,410,071...80,438,369
Ensembl chr 8:80,410,091...80,438,369 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr  X:141,100,989...141,173,792
Ensembl chr  X:141,100,989...141,173,531 		JBrowse link
G Adam19 ADAM metallopeptidase domain 19 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr11:45,945,329...46,038,174
Ensembl chr11:45,946,819...46,038,170 		JBrowse link
G Adam28 a disintegrin and metallopeptidase domain 28 exacerbates
disease_progression
treatment		 ISO protein:increased expression:lung RGD PMID:29882245 PMID:26800504 PMID:30190423 PMID:20112342 RGD:153297792, RGD:11531771, RGD:153297795, RGD:153297794 NCBI chr14:68,842,447...68,893,338
Ensembl chr14:68,843,476...68,893,291 		JBrowse link
G Adamtsl3 ADAMTS-like 3 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 7:81,984,612...82,263,658
Ensembl chr 7:81,984,902...82,263,658 		JBrowse link
G Adgrg6 adhesion G protein-coupled receptor G6 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr10:14,278,327...14,421,467
Ensembl chr10:14,278,327...14,421,403 		JBrowse link
G Ahcy S-adenosylhomocysteine hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 2:154,901,230...154,916,417
Ensembl chr 2:154,901,230...154,916,417 		JBrowse link
G Ahr aryl-hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:12597446 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Akr1a1 aldo-keto reductase family 1, member A1 disease_progression ISO RGD PMID:30727821 RGD:27226687 NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877 		JBrowse link
G Alb albumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr19:40,538,701...40,576,907
Ensembl chr19:40,538,701...40,576,907 		JBrowse link
G Alk anaplastic lymphoma kinase ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma		 CTD
ClinVar		 PMID:20979469 PMID:21823889 PMID:22071784 PMID:22135231 PMID:22153831 More... NCBI chr17:72,174,206...72,911,719
Ensembl chr17:72,175,967...72,911,622 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type ISO CTD Direct Evidence: marker/mechanism CTD PMID:30258081 NCBI chr11:69,047,898...69,060,617
Ensembl chr11:69,047,815...69,060,618 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:30258081 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139 		JBrowse link
G Alx1 ALX homeobox 1 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr10:102,834,564...102,865,501
Ensembl chr10:102,834,568...102,866,076 		JBrowse link
G Alx4 aristaless-like homeobox 4 disease_progression ISO RGD PMID:18978557 RGD:153350135 NCBI chr 2:93,472,779...93,511,686
Ensembl chr 2:93,472,729...93,511,684 		JBrowse link
G Anapc2 anaphase promoting complex subunit 2 severity ISO mRNA:decreased expression:lung (human) RGD PMID:12036940 RGD:14696682 NCBI chr 2:25,162,469...25,175,928
Ensembl chr 2:25,162,490...25,175,927 		JBrowse link
G Anp32a acidic nuclear phosphoprotein 32 family member A ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 9:62,248,637...62,286,084
Ensembl chr 9:62,248,575...62,286,094 		JBrowse link
G Anxa1 annexin A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308 		JBrowse link
G Anxa5 annexin A5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043 		JBrowse link
G Apc APC, WNT signaling pathway regulator ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr18:34,353,350...34,455,243
Ensembl chr18:34,353,977...34,455,605 		JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596 		JBrowse link
G Apoa1 apolipoprotein A-I ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Apoc3 apolipoprotein C-III ISO protein:altered glycosylation:: RGD PMID:19322776 RGD:153344619 NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934 		JBrowse link
G Aqp4 aquaporin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039 		JBrowse link
G Arg1 arginase, liver ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382 		JBrowse link
G Arhgap35 Rho GTPase activating protein 35 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr 7:16,228,398...16,349,313
Ensembl chr 7:16,227,644...16,348,918 		JBrowse link
G Arhgap44 Rho GTPase activating protein 44 ISO mRNA:decreased expression:lung (human) RGD PMID:28527113 RGD:401901290 NCBI chr11:64,892,865...65,053,779
Ensembl chr11:64,892,865...65,053,787 		JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr11:115,306,517...115,310,775
Ensembl chr11:115,306,515...115,310,788 		JBrowse link
G Atrx ATRX, chromatin remodeler disease_progression ISO RGD PMID:31374064 RGD:127285382 NCBI chr  X:104,841,221...104,972,978
Ensembl chr  X:104,841,221...104,973,009 		JBrowse link
G Axin2 axin 2 susceptibility
disease_progression		 ISO DNA:SNP:cds:p.P50S(human)
DNA:SNPs::1712 +19 G>A,148 C>T(human)		 RGD PMID:16820935 PMID:30346805 RGD:151356657, RGD:151356655 NCBI chr11:108,808,687...108,841,609
Ensembl chr11:108,811,175...108,841,609 		JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc ISO mRNA,protein:increased expression:lung RGD PMID:17724461 RGD:153350134 NCBI chr 5:137,979,783...137,988,495
Ensembl chr 5:137,979,782...137,988,495 		JBrowse link
G Bap1 Brca1 associated protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231345 NCBI chr14:30,973,358...30,981,887
Ensembl chr14:30,973,407...30,981,901 		JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 ISO mRNA:decreased expression:lung (human) RGD PMID:18223678 RGD:151665316 NCBI chr 6:145,803,969...145,811,146
Ensembl chr 6:145,803,969...145,811,284 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 exacerbates ISO mRNA:increased expression:B cell (human) RGD PMID:33098370 RGD:153323293 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 disease_progression
ameliorates		 ISO mRNA:increased expression:lung (human) RGD PMID:31964418 RGD:153344516 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Braf Braf transforming gene ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma		 CTD
ClinVar		 PMID:12068308 PMID:12198537 PMID:12447372 PMID:12460918 PMID:12460919 More... NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397 		JBrowse link
G Btk Bruton agammaglobulinemia tyrosine kinase exacerbates
susceptibility		 ISO mRNA:decreased expression:lung (human) RGD PMID:31803536 PMID:32351880 RGD:151347849, RGD:151347848 NCBI chr  X:133,443,083...133,484,366
Ensembl chr  X:133,443,085...133,484,319 		JBrowse link
G Bzw2 basic leucine zipper and W2 domains 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr12:36,141,834...36,206,922
Ensembl chr12:36,141,834...36,208,079 		JBrowse link
G Cadm1 cell adhesion molecule 1 ISO DNA, mRNA:hypermethylation, decreased expression:promoter:liver RGD PMID:16814249 RGD:2289096 NCBI chr 9:47,441,468...47,773,578
Ensembl chr 9:47,441,471...47,769,413 		JBrowse link
G Calr calreticulin treatment ISO human cells and recombinant gene in a mouse model RGD PMID:18245558 RGD:150521698 NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563 		JBrowse link
G Capg capping actin protein, gelsolin like ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 6:72,515,265...72,539,966
Ensembl chr 6:72,521,374...72,539,966 		JBrowse link
G Cbx5 chromobox 5 disease_progression ISO mRNA,protein:increased expression:lung: RGD PMID:22900142 RGD:9586743 NCBI chr15:103,099,973...103,148,337
Ensembl chr15:103,099,971...103,148,243 		JBrowse link
G Cbx7 chromobox 7 ISO mRNA,DNA:decreased expression, loss of heterozygosity:lung: RGD PMID:22214847 RGD:9587356 NCBI chr15:79,800,005...79,855,344
Ensembl chr15:79,800,008...79,855,320 		JBrowse link
G Ccnd1 cyclin D1 disease_progression
treatment		 ISO RGD PMID:26681199 PMID:19355812 RGD:11536846, RGD:13434927 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccnd2 cyclin D2 disease_progression ISO RGD PMID:30308939 RGD:151665105 NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156 		JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr15:31,590,946...31,601,992
Ensembl chr15:31,590,946...31,601,950 		JBrowse link
G Cd163 CD163 antigen ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 6:124,281,596...124,307,488
Ensembl chr 6:124,281,615...124,307,486 		JBrowse link
G Cd44 CD44 antigen disease_progression ISO mRNA:splice variants:lung
mRNA:increased expression:lung (human)		 RGD PMID:18091389 PMID:29537891 RGD:2289345, RGD:149735539 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010 		JBrowse link
G Cdc73 cell division cycle 73, Paf1/RNA polymerase II complex component exacerbates ISO mRNA:decreased expression:lung (human) RGD PMID:21692036 RGD:150537041 NCBI chr 1:143,479,014...143,578,631
Ensembl chr 1:143,474,538...143,578,631 		JBrowse link
G Cdh1 cadherin 1 ISO DNA:increased methylation RGD PMID:16329148 RGD:1599556 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdk12 cyclin dependent kinase 12 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar NCBI chr11:98,093,259...98,171,941
Ensembl chr11:98,093,885...98,169,330 		JBrowse link
G Cdk4 cyclin dependent kinase 4 ISO protein:increased expression:lung
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma		 ClinVar
RGD		 PMID:5377176 PMID:7652577 PMID:8528263 PMID:8968104 PMID:9228064 More... RGD:13464277 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789 		JBrowse link
G Cdk6 cyclin dependent kinase 6 ISO protein:increased expression:lung RGD PMID:10574260 RGD:13464325 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 susceptibility
ameliorates		 ISO mRNA:increased expression:lung (human)
DNA:missense mutation:CDS:p.D140E (rs7479004) (human)
human cells in a mouse model		 RGD PMID:28486105 PMID:29667179 PMID:32228507 RGD:153323299, RGD:151660359, RGD:153323307 NCBI chr 6:125,073,144...125,107,554
Ensembl chr 6:125,072,944...125,107,554 		JBrowse link
G Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 susceptibility ISO mRNA,protein:decreased expression:lung
ClinVar Annotator: match by term: Lung adenocarcinoma
DNA:SNPs:multiples:multiples (human)
protein:increased expression:lung
DNA:SNP: :rs8042374(human)
associated with smoking; DNA:SNP: :rs1051730(human)		 ClinVar
RGD		 PMID:27993330 PMID:19223495 PMID:25233467 PMID:24686516 PMID:24686516 More... RGD:150524354, RGD:151347535, RGD:151347530, RGD:151347530, RGD:150527848 NCBI chr 9:54,917,401...54,933,846
Ensembl chr 9:54,917,395...54,933,846 		JBrowse link
G Chrna5 cholinergic receptor, nicotinic, alpha polypeptide 5 susceptibility
disease_progression		 ISO DNA:SNP:cds: p.D398N (rs1696996)(human)
ClinVar Annotator: match by term: Lung adenocarcinoma
mRNA:increased expression:lung
DNA:SNP: :rs503464(human)
associated with smoking; DNA:SNPs: :rs2036527, rs684513, rs667282(human)
DNA:SNP:cds: p.D398N(human)		 ClinVar
RGD		 PMID:27993330 PMID:19223495 PMID:20124469 PMID:23314339 PMID:20554942 More... RGD:150524354, RGD:150527851, RGD:150527849, RGD:150527848, RGD:150524359, RGD:150524356 NCBI chr 9:54,888,112...54,918,704
Ensembl chr 9:54,888,164...54,915,063 		JBrowse link
G Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 ISO mRNA:increased expression:lung
DNA:hypomethylation:promoter:		 RGD PMID:20124469 PMID:22945651 RGD:150527851, RGD:151361154 NCBI chr 9:54,935,438...54,956,236
Ensembl chr 9:54,935,438...54,956,063 		JBrowse link
G Clptm1l CLPTM1-like susceptibility
no_association
ameliorates		 ISO CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs401681(human)
DNA:SNP::rs77518573(human)
DNA:SNP:: rs4975616(human)
DNA:SNP::rs401681(human)
DNA:SNP:: rs31490(human)
mRNA:increased expression:lung		 CTD
RGD		 PMID:22675468 PMID:24386361 PMID:31935503 PMID:19955392 PMID:24861918 More... RGD:150537098, RGD:150530635, RGD:150530502, RGD:150530499, RGD:150530498, RGD:150530485, RGD:150530483, RGD:150530483 NCBI chr13:73,752,121...73,768,758
Ensembl chr13:73,752,125...73,768,724 		JBrowse link
G Cmtr2 cap methyltransferase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr 8:110,941,977...110,951,121
Ensembl chr 8:110,942,297...110,951,118 		JBrowse link
G Col10a1 collagen, type X, alpha 1 disease_progression ISO mRNA:increased expression:lung RGD PMID:33324550 PMID:33324550 RGD:150429752, RGD:150429752 NCBI chr10:34,265,977...34,273,081
Ensembl chr10:34,265,977...34,273,081 		JBrowse link
G Crebbp CREB binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861 		JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO protein:increased expression:lung (human) RGD PMID:23702648 RGD:150524280 NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221 		JBrowse link
G Csrp3 cysteine and glycine-rich protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 7:48,480,146...48,497,799
Ensembl chr 7:48,480,146...48,497,781 		JBrowse link
G Ctnnb1 catenin beta 1 ISO ClinVar Annotator: match by term: Adenocarcinoma of lung
ClinVar Annotator: match by term: Lung adenocarcinoma		 ClinVar PMID:10192393 PMID:25741868 PMID:26619011 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 exacerbates ISO protein:increased expression:lung (human)
mRNA:increased expression:lung (human)		 RGD PMID:30103827 PMID:19716197 RGD:152023735, RGD:152177480 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 ISO protein:increased expression:lung (human) RGD PMID:19358281 RGD:152177688 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 ameliorates ISO DNA:hypomethylation:promoter (human)
mRNA:decreased expression:lung (human)
human cell line in a mouse model		 RGD PMID:24736069 PMID:25519225 PMID:27793774 RGD:151361181, RGD:151665499, RGD:151665173 NCBI chr 2:170,324,877...170,339,065
Ensembl chr 2:170,324,628...170,339,065 		JBrowse link
G Ddr2 discoidin domain receptor family, member 2 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma		 CTD
ClinVar		 PMID:26206333 PMID:27993330 NCBI chr 1:169,799,874...169,938,525
Ensembl chr 1:169,799,876...169,938,331 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 treatment ISO RGD PMID:33628824 RGD:155663482 NCBI chr 2:119,156,286...119,166,145
Ensembl chr 2:119,156,265...119,166,443 		JBrowse link
G Dnmt3a DNA methyltransferase 3A ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:21067377 PMID:21518476 PMID:22160010 PMID:22722925 PMID:22744846 More... NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443 		JBrowse link
G Dnmt3b DNA methyltransferase 3B susceptibility ISO DNA:SNPs,haplotype:promoter:-283T >C,-579G>T(human) RGD PMID:15528220 RGD:9589086 NCBI chr 2:153,491,332...153,529,650
Ensembl chr 2:153,491,370...153,529,650 		JBrowse link
G Dok1 docking protein 1 disease_progression IMP RGD PMID:20139980 RGD:152177521 NCBI chr 6:83,007,915...83,010,448
Ensembl chr 6:83,007,915...83,010,452 		JBrowse link
G Dok2 docking protein 2 disease_progression
exacerbates		 IGI
ISO
IMP		 mRNA:decreased expression:lung (human) RGD PMID:20139980 PMID:30475228 PMID:20139980 PMID:24255704 RGD:152177521, RGD:152177492, RGD:152177521, RGD:152177493 NCBI chr14:71,003,336...71,015,934
Ensembl chr14:71,003,476...71,015,935 		JBrowse link
G Dok3 docking protein 3 disease_progression IMP RGD PMID:20139980 RGD:152177521 NCBI chr13:55,671,044...55,678,158
Ensembl chr13:55,671,044...55,677,109 		JBrowse link
G Dot1l DOT1 like histone lysine methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr10:80,590,935...80,631,295
Ensembl chr10:80,591,040...80,631,295 		JBrowse link
G E2f1 E2F transcription factor 1 ISO mRNA:increased expression:lung RGD PMID:26695082 RGD:13464334 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G E2f3 E2F transcription factor 3 ISO RGD PMID:16938365 RGD:13464341 NCBI chr13:30,090,558...30,171,172
Ensembl chr13:30,090,558...30,170,046 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 exacerbates ISO protein:increased expression:lung (human) RGD PMID:21554491 RGD:153298904 NCBI chr10:81,012,465...81,018,343
Ensembl chr10:81,012,465...81,018,332 		JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase ameliorates ISO Human cells in mouse model RGD PMID:30522114 RGD:153298964 NCBI chr 7:120,442,080...120,506,441
Ensembl chr 7:120,442,054...120,506,673 		JBrowse link
G Egf epidermal growth factor ISO DNA:polymorphism: :p.A61G (human) RGD PMID:26625757 RGD:11538684 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Egfr epidermal growth factor receptor disease_progression ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Adenocarcinoma of lung, somatic | ClinVar Annotator: match by term: Lung adenocarcinoma		 CTD
ClinVar
RGD		 PMID:11423618 PMID:15118073 PMID:15118125 PMID:15272417 PMID:15329413 More... RGD:126790475 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Ehmt2 euchromatic histone lysine N-methyltransferase 2 disease_progression ISO RGD PMID:20940408 RGD:9589170 NCBI chr17:35,117,427...35,133,049
Ensembl chr17:35,117,445...35,133,028 		JBrowse link
G Eif2b1 eukaryotic translation initiation factor 2B, subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 5:124,708,277...124,717,194
Ensembl chr 5:124,708,276...124,717,194 		JBrowse link
G Eif2b4 eukaryotic translation initiation factor 2B, subunit 4 delta ISO CTD Direct Evidence: marker/mechanism CTD PMID:24366584 NCBI chr 5:31,344,902...31,350,483
Ensembl chr 5:31,344,902...31,350,774 		JBrowse link
G Eif2b5 eukaryotic translation initiation factor 2B, subunit 5 epsilon ISO CTD Direct Evidence: marker/mechanism CTD PMID:24366584 NCBI chr16:20,317,544...20,328,073
Ensembl chr16:20,317,567...20,328,073 		JBrowse link
G Eif3e eukaryotic translation initiation factor 3, subunit E ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr15:43,113,436...43,146,132
Ensembl chr15:43,113,454...43,146,115 		JBrowse link
G Eml4 echinoderm microtubule associated protein like 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22980554 PMID:22999080 NCBI chr17:83,658,341...83,787,790
Ensembl chr17:83,658,360...83,787,790 		JBrowse link
G Emx2 empty spiracles homeobox 2 exacerbates ISO mRNA,protein:decreased expression:lung (human) RGD PMID:21726823 RGD:153323303 NCBI chr19:59,447,122...59,453,789
Ensembl chr19:59,446,804...59,453,789 		JBrowse link
G Eno1 enolase 1, alpha non-neuron ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 PMID:27602772 NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336
Ensembl chr18:150,321,178...150,333,336 		JBrowse link
G Ep300 E1A binding protein p300 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 disease_progression ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar
RGD		 PMID:15457249 PMID:15753357 PMID:16638863 PMID:18334834 PMID:22325357 More... RGD:126790475 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 disease_progression ISO RGD PMID:26824984 RGD:126790475 NCBI chr10:128,403,392...128,425,504
Ensembl chr10:128,403,392...128,425,521 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 disease_progression ISO RGD PMID:26824984 RGD:126790475 NCBI chr 1:68,071,063...69,147,756
Ensembl chr 1:68,071,345...69,147,218 		JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21327329 NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449 		JBrowse link
G Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 ISO mRNA, protein:increased expression:lung (human) RGD PMID:31615563 RGD:155260344 NCBI chr14:32,235,248...32,302,947
Ensembl chr14:32,235,478...32,302,947 		JBrowse link
G Ercc6l excision repair cross-complementing rodent repair deficiency complementation group 6 like exacerbates ISO mRNA:increased expression:lung (human) RGD PMID:35150321 RGD:155260359 NCBI chr  X:101,186,426...101,200,697
Ensembl chr  X:101,185,322...101,200,697 		JBrowse link
G Ergic3 ERGIC and golgi 3 ameliorates
disease_progression		 IMP
ISO		 mRNA,protein:increased expression:lung (human) RGD PMID:27588471 PMID:23374247 RGD:153323314, RGD:151708716 NCBI chr 2:155,849,948...155,860,199
Ensembl chr 2:155,849,965...155,860,199 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 5:121,582,816...121,590,537
Ensembl chr 5:121,566,653...121,590,569 		JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 ameliorates ISO RGD PMID:33573689 RGD:155791670 NCBI chr14:66,056,476...66,071,418
Ensembl chr14:66,056,487...66,071,443 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit disease_progression ISO RGD PMID:24097870 RGD:126781716 NCBI chr 6:47,507,208...47,613,843
Ensembl chr 6:47,507,073...47,572,275 		JBrowse link
G Fas Fas cell surface death receptor ISO mRNA:decreased expression:lung (human) RGD PMID:29254206 RGD:151665107 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasn fatty acid synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Fbl fibrillarin ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 7:27,868,293...27,878,701
Ensembl chr 7:27,869,135...27,878,694 		JBrowse link
G Fes feline sarcoma oncogene treatment ISO human cells in a mouse model RGD PMID:31573955 RGD:153323295 NCBI chr 7:80,027,506...80,037,702
Ensembl chr 7:80,027,504...80,037,694 		JBrowse link
G Fgf10 fibroblast growth factor 10 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr13:118,851,199...118,928,651
Ensembl chr13:118,806,327...118,928,651 		JBrowse link
G Fgf18 fibroblast growth factor 18 ISO mRNA:decreased expression:lung (human) RGD PMID:19296538 RGD:150429981 NCBI chr11:33,066,970...33,097,400
Ensembl chr11:33,067,430...33,097,400 		JBrowse link
G Fgf9 fibroblast growth factor 9 disease_progression ISO protein:increased expression:lung (human)
mRNA:decreased expression:lung (human)		 RGD PMID:19296538 PMID:19358281 PMID:20464547 RGD:150429981 RGD:152177688, RGD:152975620 NCBI chr14:58,308,543...58,350,311
Ensembl chr14:58,308,004...58,350,177 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 disease_progression
exacerbates		 ISO DNA:SNP:exon 9: p.G288R (human)
DNA:SNP:exon 9: p.G388R (rs351855)(human)
human cells in mouse model		 RGD PMID:16061909 PMID:19296538 PMID:29402970 RGD:150429976, RGD:150429981, RGD:150429984 NCBI chr13:55,300,631...55,316,572
Ensembl chr13:55,300,453...55,316,572 		JBrowse link
G Fkbp11 FK506 binding protein 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr15:98,622,249...98,626,079
Ensembl chr15:98,622,247...98,626,079 		JBrowse link
G Flt1 FMS-like tyrosine kinase 1 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821 		JBrowse link
G Foxa1 forkhead box A1 ISO mRNA:increased expression:lung
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:34254728 PMID:12234996 PMID:29072684 RGD:151665758, RGD:151665822 NCBI chr12:57,585,750...57,594,815
Ensembl chr12:57,587,414...57,593,702 		JBrowse link
G Foxo3 forkhead box O3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19380174 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Foxp1 forkhead box P1 ISO mRNA:decreased expression:lung (rat) RGD PMID:16023287 RGD:11561933 NCBI chr 6:98,902,303...99,510,587
Ensembl chr 6:98,902,299...99,499,682 		JBrowse link
G Foxp2 forkhead box P2 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 6:14,901,348...15,441,976
Ensembl chr 6:14,901,348...15,441,976 		JBrowse link
G Foxp4 forkhead box P4 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr17:48,178,058...48,235,401
Ensembl chr17:48,178,058...48,235,570 		JBrowse link
G Fpr2 formyl peptide receptor 2 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr17:18,108,086...18,114,214
Ensembl chr17:18,108,086...18,114,214 		JBrowse link
G Frzb frizzled-related protein severity ISO mRNA:decreased expression:lung (human) RGD PMID:27623992 RGD:32716395 NCBI chr 2:80,242,314...80,277,740
Ensembl chr 2:80,242,314...80,277,969 		JBrowse link
G Fubp1 far upstream element (FUSE) binding protein 1 ISO mRNA:decreased expression:lung (human) RGD PMID:32481602 RGD:151361197 NCBI chr 3:151,916,059...151,942,467
Ensembl chr 3:151,916,059...151,942,463 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430 		JBrowse link
G Gar1 GAR1 ribonucleoprotein ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 3:129,618,561...129,625,045
Ensembl chr 3:129,618,561...129,625,045 		JBrowse link
G Gart phosphoribosylglycinamide formyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr16:91,418,283...91,444,505
Ensembl chr16:91,418,074...91,443,840 		JBrowse link
G Gjb2 gap junction protein, beta 2 ISO DNA, mRNA:hypermethylation, decreased expression:lung RGD PMID:16637067 RGD:11568669 NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159 		JBrowse link
G Gng11 guanine nucleotide binding protein (G protein), gamma 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24366584 NCBI chr 6:4,003,987...4,008,445
Ensembl chr 6:4,003,904...4,008,445 		JBrowse link
G Gnpnat1 glucosamine-phosphate N-acetyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr14:45,613,897...45,626,972
Ensembl chr14:45,613,791...45,642,370 		JBrowse link
G Golm1 golgi membrane protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr13:59,782,810...59,823,598
Ensembl chr13:59,782,440...59,823,625 		JBrowse link
G Gpi1 glucose-6-phosphate isomerase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 7:33,900,752...33,929,761
Ensembl chr 7:33,900,755...33,929,761 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO mRNA:decreased expression:lung (human) RGD PMID:23374247 RGD:151708716 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Grwd1 glutamate-rich WD repeat containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 7:45,474,647...45,480,218
Ensembl chr 7:45,474,647...45,480,368 		JBrowse link
G H1f10 H1.10 linker histone EXP CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 6:87,957,403...87,958,464
Ensembl chr 6:87,957,403...87,958,619 		JBrowse link
G H2bc4 H2B clustered histone 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr13:23,868,182...23,876,805
Ensembl chr13:23,868,182...23,876,891 		JBrowse link
G Hells helicase, lymphoid specific ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr19:38,913,282...38,958,914
Ensembl chr19:38,919,359...38,959,495 		JBrowse link
G Hk1 hexokinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr10:62,104,634...62,215,699
Ensembl chr10:62,104,634...62,215,687 		JBrowse link
G Hk2 hexokinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 6:82,702,004...82,751,437
Ensembl chr 6:82,702,006...82,751,435 		JBrowse link
G Hmgb2 high mobility group box 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24366584 PMID:27602772 NCBI chr 8:57,964,877...57,969,033
Ensembl chr 8:57,964,941...57,969,033 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr15:103,148,840...103,155,119
Ensembl chr15:103,148,859...103,155,119 		JBrowse link
G Hoxb7 homeobox B7 severity ISO protein:increased expression:lung epithelium (human) RGD PMID:22911672 RGD:10402176 NCBI chr11:96,176,431...96,180,989
Ensembl chr11:96,177,449...96,180,988 		JBrowse link
G Hras Harvey rat sarcoma virus oncogene ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma		 CTD
ClinVar		 PMID:1904555 PMID:3510078 PMID:11150980 PMID:12835555 PMID:16155195 More... NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr  X:150,784,892...150,787,438
Ensembl chr  X:150,784,841...150,787,438 		JBrowse link
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 ISO mRNA:increased expression:lung (human) RGD PMID:23374247 RGD:151708716 NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373 		JBrowse link
G Hspb1 heat shock protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417 		JBrowse link
G Htr4 5 hydroxytryptamine (serotonin) receptor 4 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr18:62,456,618...62,636,098
Ensembl chr18:62,457,275...62,629,648 		JBrowse link
G Htra1 HtrA serine peptidase 1 disease_progression ISO human cells in mouse model RGD PMID:24356998 RGD:152975621 NCBI chr 7:130,537,933...130,587,388
Ensembl chr 7:130,537,841...130,587,390 		JBrowse link
G Idh1 isocitrate dehydrogenase 1 (NADP+), soluble disease_progression ISO mRNA:increased expression:lung (human)
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma
protein:increased expression:blood plasma (human)		 ClinVar
RGD		 PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20946881 More... RGD:149735539, RGD:149735540 NCBI chr 1:65,197,775...65,225,638
Ensembl chr 1:65,197,775...65,225,659 		JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial severity ISO protein:increased expression:lung (human)
protein:increased expression:blood serum (human)		 RGD PMID:30128035 PMID:29465809 RGD:149735564, RGD:149735567 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
G Igf2r insulin-like growth factor 2 receptor ISO mRNA:deletions: :c.3698_4902del, c.3366_4902del, c.3817_4697del (rat) RGD PMID:12503077 RGD:1298968 NCBI chr17:12,901,293...12,988,593
Ensembl chr17:12,901,293...12,988,551 		JBrowse link
G Ikzf1 IKAROS family zinc finger 1 exacerbates
ameliorates		 ISO protein:increased expression:lung (human)
mRNA:increased expression:lung (human)		 RGD PMID:33738286 PMID:32787735 RGD:151347632, RGD:150540324 NCBI chr11:11,634,970...11,722,930
Ensembl chr11:11,634,980...11,722,926 		JBrowse link
G Il1r2 interleukin 1 receptor, type II disease_progression
severity		 ISO mRNA:altered expression:lung (human)
mRNA:increased expression:lung (human)		 RGD PMID:31921619 PMID:29942094 RGD:152998982, RGD:152998998 NCBI chr 1:40,123,872...40,164,390
Ensembl chr 1:40,113,239...40,164,391 		JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 9:108,437,635...108,442,776
Ensembl chr 9:108,437,485...108,442,783 		JBrowse link
G Ipo4 importin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr14:55,862,857...55,873,321
Ensembl chr14:55,862,857...55,873,414 		JBrowse link
G Ipo5 importin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr14:121,134,271...121,185,451
Ensembl chr14:121,148,636...121,185,411 		JBrowse link
G Iqsec1 IQ motif and Sec7 domain 1 disease_progression ISO RGD PMID:24902879 RGD:153350085 NCBI chr 6:90,636,578...90,965,766
Ensembl chr 6:90,633,070...90,965,667 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 ISO mRNA:increased expression:lung (human) RGD PMID:21278795 RGD:36049796 NCBI chr10:119,977,553...120,038,035
Ensembl chr10:119,977,553...120,038,035 		JBrowse link
G Ireb2 iron responsive element binding protein 2 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 9:54,769,942...54,819,812
Ensembl chr 9:54,771,073...54,819,814 		JBrowse link
G Jak2 Janus kinase 2 treatment ISO human cells in mouse model RGD PMID:27025877 RGD:11574134 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Junb jun B proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:24366584 NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347 		JBrowse link
G Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30512237 NCBI chr15:79,364,427...79,396,712
Ensembl chr15:79,367,915...79,389,442 		JBrowse link
G Klf5 Kruppel-like transcription factor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr14:99,536,127...99,550,848
Ensembl chr14:99,536,127...99,552,472 		JBrowse link
G Kmt2c lysine (K)-specific methyltransferase 2C disease_progression
onset		 ISO RGD PMID:32867667 PMID:30821106 RGD:151356760, RGD:151356761 NCBI chr 5:25,476,793...25,703,853
Ensembl chr 5:25,476,796...25,703,781 		JBrowse link
G Kpna2 karyopherin subunit alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr11:106,879,455...106,890,351
Ensembl chr11:106,879,455...106,890,367 		JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog ISO DNA:point mutation:CDS:p.G12C (human)
ClinVar Annotator: match by term: Lung adenocarcinoma
ClinVar Annotator: match by term: Adenocarcinoma of lung
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
RGD		 PMID:2278970 PMID:3122217 PMID:6320174 PMID:8143615 PMID:8425762 More... RGD:1600465 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Ldha lactate dehydrogenase A ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051 		JBrowse link
G Lect2 leukocyte cell-derived chemotaxin 2 ameliorates ISO human cells in mouse model RGD PMID:30453282 RGD:153323337 NCBI chr13:56,676,772...56,696,373
Ensembl chr13:56,690,277...56,696,315 		JBrowse link
G Lmna lamin A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263 		JBrowse link
G Lmnb1 lamin B1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr18:56,840,885...56,886,496
Ensembl chr18:56,840,885...56,886,496 		JBrowse link
G Lrp1b low density lipoprotein-related protein 1B disease_progression ISO DNA:mutations:multiple: (human) RGD PMID:18948947 RGD:11064706 NCBI chr 2:40,485,302...42,543,747
Ensembl chr 2:40,485,258...42,543,636 		JBrowse link
G Lrrc56 leucine rich repeat containing 56 ISO ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:1904555 PMID:3510078 PMID:11150980 PMID:12835555 PMID:16155195 More... NCBI chr 7:140,774,024...140,789,968
Ensembl chr 7:140,774,070...140,789,968 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:lung (human)		 CTD
RGD		 PMID:22135231 PMID:29254206 RGD:151665107 NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913 		JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 severity IMP RGD PMID:21896780 PMID:12231543 RGD:150429783, RGD:150429821 NCBI chr11:65,579,070...65,679,185
Ensembl chr11:65,579,069...65,679,123 		JBrowse link
G Map2k7 mitogen-activated protein kinase kinase 7 exacerbates ISO human gene in a mouse model RGD PMID:34236045 RGD:155230828 NCBI chr 8:4,288,740...4,297,897
Ensembl chr 8:4,288,740...4,297,897
Ensembl chr 8:4,288,740...4,297,897 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 exacerbates IMP RGD PMID:23533274 RGD:151356978 NCBI chr18:4,331,325...4,352,978
Ensembl chr18:4,331,327...4,353,015 		JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 ameliorates
exacerbates		 ISO human cell line in a mouse model
mRNA, protein:increased expression:lung (human)		 RGD PMID:22824148 PMID:28306189 PMID:33510968 RGD:151347677, RGD:151347678, RGD:151347681 NCBI chr 1:39,939,806...40,065,470
Ensembl chr 1:39,940,073...40,065,470 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 exacerbates HEP mRNA:increased expression:lung (human) RGD PMID:31969449 RGD:151665505 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 severity
treatment		 ISO mRNA:increased expression:lung (human)
human cells in mouse model		 RGD PMID:31200834 PMID:31200834 RGD:151356911, RGD:151356911 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487 		JBrowse link
G Meox1 mesenchyme homeobox 1 ISO CTD Direct Evidence: therapeutic CTD PMID:34837450 NCBI chr11:101,768,336...101,785,309
Ensembl chr11:101,768,336...101,785,200 		JBrowse link
G Mier3 MIER family member 3 ameliorates ISO RGD PMID:35117188 RGD:407571696 NCBI chr13:111,822,607...111,855,130
Ensembl chr13:111,817,513...111,855,130 		JBrowse link
G Mir127 microRNA 127 treatment ISO Human cells in mouse model RGD PMID:27869168 RGD:152995353 NCBI chr12:109,559,280...109,559,349
Ensembl chr12:109,559,280...109,559,349 		JBrowse link
G Mir154 microRNA 154 ISO associated with nicotine dependence; RNA:decreased expression:blood serum (human) RGD PMID:25386559 RGD:152995475 NCBI chr12:109,704,867...109,704,932
Ensembl chr12:109,704,867...109,704,932 		JBrowse link
G Mir20a microRNA 20a ISO RGD PMID:26560875 RGD:11572141 NCBI chr14:115,281,589...115,281,695
Ensembl chr14:115,281,589...115,281,695 		JBrowse link
G Mir21a microRNA 21a disease_progression ISO
IEP		 RNA:increased expression:lung (human)
miRNA:increased expression:sputum (human)		 RGD PMID:29892003 PMID:27777637 RGD:152998892, RGD:152998954 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984 		JBrowse link
G Mir31 microRNA 31 severity
disease_progression		 ISO RNA:increased expression:lung (human) RGD PMID:26657862 PMID:29367106 PMID:23946296 PMID:27215092 RGD:11343268, RGD:152998945, RGD:152998944, RGD:11250998 NCBI chr 4:88,828,794...88,828,899
Ensembl chr 4:88,828,794...88,828,899 		JBrowse link
G Mir432 microRNA 432 disease_progression ISO mRNA:decreased expression:lung (human)
human cells in mouse model		 RGD PMID:26942465 PMID:26942465 RGD:152999419, RGD:152999419 NCBI chr12:109,561,390...109,561,464
Ensembl chr12:109,561,390...109,561,464 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 disease_progression ISO protein:altered expression:lung (human) RGD PMID:26942465 RGD:152999419 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Mlh1 mutL homolog 1 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 9:111,057,296...111,100,854
Ensembl chr 9:111,057,296...111,100,859 		JBrowse link
G Mre11a MRE11A homolog A, double strand break repair nuclease EXP CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 9:14,695,971...14,748,421
Ensembl chr 9:14,695,950...14,748,419 		JBrowse link
G Mrpl12 mitochondrial ribosomal protein L12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr11:120,375,463...120,379,580
Ensembl chr11:120,375,439...120,379,891 		JBrowse link
G Mrps5 mitochondrial ribosomal protein S5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 2:127,429,346...127,445,906
Ensembl chr 2:127,429,142...127,448,749 		JBrowse link
G Ms4a1 membrane-spanning 4-domains, subfamily A, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22514692 NCBI chr19:11,227,043...11,243,513
Ensembl chr19:11,227,039...11,243,605 		JBrowse link
G Msh2 mutS homolog 2 no_association ISO DNA:polymorphisms:introns:IVS10+12A>G, IVS12-6T>C (human)
DNA:polymorphisms:promoter, intron:-118T>C, IVS1+9G>C (human)		 RGD PMID:16614121 PMID:16614121 RGD:11065547, RGD:11065547 NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141 		JBrowse link
G Msh3 mutS homolog 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21327329 NCBI chr13:92,348,387...92,491,515
Ensembl chr13:92,348,380...92,491,511 		JBrowse link
G Msh6 mutS homolog 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21327329 NCBI chr17:88,282,478...88,298,320
Ensembl chr17:88,282,490...88,298,320 		JBrowse link
G Muc1 mucin 1, transmembrane ISO mRNA:increased expression:lung RGD PMID:8694545 RGD:5131260 NCBI chr 3:89,136,363...89,140,688
Ensembl chr 3:89,136,364...89,140,688 		JBrowse link
G Muc4 mucin 4 disease_progression ISO protein:increased expression:trachea RGD PMID:17126950 RGD:5131208 NCBI chr16:32,555,089...32,602,786
Ensembl chr16:32,555,015...32,602,754 		JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968 		JBrowse link
G Myc myelocytomatosis oncogene ISO human cell line in mouse model
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:26656844 PMID:27602772 PMID:20033209 RGD:7207787 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 treatment
ameliorates		 IMP mouse cell line in a mouse model RGD PMID:32140881 PMID:30712876 RGD:150520172, RGD:150540309 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477 		JBrowse link
G Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr  X:72,960,476...72,965,550
Ensembl chr  X:72,960,479...72,965,550 		JBrowse link
G Naip2 NLR family, apoptosis inhibitory protein 2 ameliorates ISO mRNA:increased expression:lung (human) RGD PMID:31964418 RGD:153344516 NCBI chr13:100,280,571...100,338,630
Ensembl chr13:100,280,571...100,338,600 		JBrowse link
G Ncapg non-SMC condensin I complex, subunit G ISO CTD Direct Evidence: marker/mechanism CTD PMID:34419073 NCBI chr 5:45,827,212...45,858,491
Ensembl chr 5:45,827,261...45,857,888 		JBrowse link
G Ncl nucleolin ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 1:86,272,441...86,287,177
Ensembl chr 1:86,272,441...86,287,122 		JBrowse link
G Nkx2-1 NK2 homeobox 1 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr12:56,578,741...56,583,570
Ensembl chr12:56,578,743...56,583,693 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nop56 NOP56 ribonucleoprotein ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 2:130,112,904...130,121,233
Ensembl chr 2:130,116,350...130,121,233 		JBrowse link
G Nop58 NOP58 ribonucleoprotein ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 1:59,724,165...59,751,352
Ensembl chr 1:59,724,130...59,758,203 		JBrowse link
G Notch1 notch 1 treatment ISO RGD PMID:33628824 RGD:155663482 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675 		JBrowse link
G Npm1 nucleophosmin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr11:33,102,498...33,114,143
Ensembl chr11:33,102,287...33,113,206 		JBrowse link
G Npm3 nucleoplasmin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr19:45,736,173...45,738,004
Ensembl chr19:45,736,173...45,738,030 		JBrowse link
G Nudt21 nudix hydrolase 21 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 8:94,746,031...94,763,667
Ensembl chr 8:94,742,124...94,763,659 		JBrowse link
G Nuf2 NUF2, NDC80 kinetochore complex component disease_progression ISO RGD PMID:32226507 RGD:28912743 NCBI chr 1:169,325,503...169,359,033
Ensembl chr 1:169,325,503...169,359,033 		JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23951099 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029 		JBrowse link
G Pabpc4 poly(A) binding protein, cytoplasmic 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 4:123,172,722...123,192,718
Ensembl chr 4:123,156,144...123,192,718 		JBrowse link
G Pacrg PARK2 co-regulated ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:12719539 NCBI chr17:10,621,938...11,059,078
Ensembl chr17:10,621,941...11,059,198 		JBrowse link
G Pcbd1 pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr10:60,925,110...60,930,108
Ensembl chr10:60,925,110...60,930,103 		JBrowse link
G Pign phosphatidylinositol glycan anchor biosynthesis, class N ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 1:105,446,147...105,591,466
Ensembl chr 1:105,446,147...105,591,402 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma		 CTD
ClinVar		 PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 More... NCBI chr 3:32,451,203...32,520,256
Ensembl chr 3:32,451,820...32,522,635 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO mRNA:decreased expression:lung RGD PMID:26695082 RGD:13464334 NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725 		JBrowse link
G Pitx2 paired-like homeodomain transcription factor 2 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 3:128,993,527...129,013,243
Ensembl chr 3:128,993,527...129,013,240 		JBrowse link
G Plcg1 phospholipase C, gamma 1 exacerbates ISO protein:decreased expression:lung (human) RGD PMID:33077911 RGD:151356960 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680 		JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 disease_progression ISO RGD PMID:29072684 RGD:151665822 NCBI chr 9:92,421,828...92,490,481
Ensembl chr 9:92,424,276...92,490,481 		JBrowse link
G Pold1 polymerase (DNA directed), delta 1, catalytic subunit exacerbates ISO protein:increased expression:lung (human) RGD PMID:33442399 RGD:153323317 NCBI chr 7:44,182,168...44,198,239
Ensembl chr 7:44,182,170...44,198,273 		JBrowse link
G Polr1d polymerase (RNA) I polypeptide D ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 5:147,013,525...147,048,171
Ensembl chr 5:147,013,860...147,048,407 		JBrowse link
G Ppan peter pan homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 9:20,799,471...20,803,475
Ensembl chr 9:20,799,471...20,803,474 		JBrowse link
G Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488 		JBrowse link
G Pramex1 PRAME like, X-linked 1 ISO mRNA:decreased expression:lung (human) RGD PMID:27241212 RGD:11535020 NCBI chr  X:134,513,662...134,528,437
Ensembl chr  X:134,513,751...134,528,454 		JBrowse link
G Prdm1 PR domain containing 1, with ZNF domain exacerbates ISO RGD PMID:28378641 RGD:150530469 NCBI chr10:44,313,170...44,404,579
Ensembl chr10:44,313,173...44,404,497 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:10072423 PMID:12719539 PMID:20301651 PMID:22956510 PMID:25741868 More... NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr19:15,882,487...15,902,423
Ensembl chr19:15,882,042...15,924,701 		JBrowse link
G Ptch1 patched 1 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar
RGD		 PMID:27993330 PMID:28492532 PMID:33359005 RGD:150524339 NCBI chr13:63,656,142...63,721,274
Ensembl chr13:63,656,142...63,721,412 		JBrowse link
G Pten phosphatase and tensin homolog ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 exacerbates
susceptibility		 ISO mRNA,protein:decreased expression:lung
DNA:missense mutations:cds:p.I1522M, p.Y2081D (human)		 RGD PMID:22245727 PMID:33536603 PMID:19672627 RGD:152176663, RGD:152975626, RGD:152176665 NCBI chr 5:103,573,058...103,746,227
Ensembl chr 5:103,573,058...103,746,169 		JBrowse link
G Ptprb protein tyrosine phosphatase receptor type B disease_progression ISO mRNA:altered expression:lung (human)
mRNA:decreased expression:lung (human)		 RGD PMID:29254206 PMID:7981622 RGD:151665107, RGD:151665112 NCBI chr10:116,111,407...116,225,443
Ensembl chr10:116,111,428...116,225,440 		JBrowse link
G Ptprj protein tyrosine phosphatase receptor type J susceptibility ISO DNA:missense mutations:cds:p.R326Q, p.Q276P (human) RGD PMID:19672627 RGD:152176665 NCBI chr 2:90,260,100...90,411,102
Ensembl chr 2:90,260,098...90,410,991 		JBrowse link
G Rac1 Rac family small GTPase 1 exacerbates
ameliorates		 ISO
IGI		 mRNA:increased expression:lung (human) RGD PMID:31779616 PMID:32366477 RGD:152998910, RGD:153345550 NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791 		JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 ISO ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:1760348 PMID:8601312 PMID:10064593 PMID:12077328 PMID:17603482 More... NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596 		JBrowse link
G Rangrf RAN guanine nucleotide release factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr11:68,863,310...68,866,011
Ensembl chr11:68,863,310...68,866,011 		JBrowse link
G Rarb retinoic acid receptor, beta ISO DNA:hypomethylation:lung RGD PMID:26695082 RGD:13464334 NCBI chr14:5,387,365...6,038,924
Ensembl chr14:5,650,540...6,038,924 		JBrowse link
G Rasa1 RAS p21 protein activator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr13:85,362,893...85,437,487
Ensembl chr13:85,362,899...85,437,249 		JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
G Rbm10 RNA binding motif protein 10 ISO mRNA, protein:decreased expression:lung
DNA:missense mutations, protein-truncating variants: :multiple		 RGD PMID:29085465 PMID:22980975 PMID:30955253 RGD:151356983, RGD:11097386, RGD:151356984 NCBI chr  X:20,483,596...20,517,128
Ensembl chr  X:20,483,742...20,517,140 		JBrowse link
G Rcl1 RNA terminal phosphate cyclase-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr19:29,078,761...29,121,251
Ensembl chr19:29,078,775...29,121,329 		JBrowse link
G Rfc4 replication factor C (activator 1) 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr16:22,932,698...22,946,480
Ensembl chr16:22,932,693...22,946,487 		JBrowse link
G Rin3 Ras and Rab interactor 3 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr12:102,248,572...102,358,982
Ensembl chr12:102,249,307...102,357,114 		JBrowse link
G Rnaseh2a ribonuclease H2, large subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:34254728 NCBI chr 8:85,683,239...85,694,498
Ensembl chr 8:85,683,239...85,696,396 		JBrowse link
G Rnf43 ring finger protein 43 severity ISO human cells in a mouse model RGD PMID:31286874 RGD:151361222 NCBI chr11:87,553,913...87,626,365
Ensembl chr11:87,553,548...87,626,365 		JBrowse link
G Ros1 Ros1 proto-oncogene ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma		 CTD
ClinVar		 PMID:22215748 PMID:27993330 NCBI chr10:51,920,959...52,071,494
Ensembl chr10:51,921,817...52,071,340 		JBrowse link
G Rpl10a ribosomal protein L10A ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr17:28,547,557...28,550,007
Ensembl chr17:28,547,445...28,550,007 		JBrowse link
G Rpl13a ribosomal protein L13A ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 7:44,774,987...44,778,169
Ensembl chr 7:44,774,982...44,778,185 		JBrowse link
G Rpl27a ribosomal protein L27A ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 7:109,118,354...109,121,967
Ensembl chr 7:109,118,354...109,121,574 		JBrowse link
G Rpl36a ribosomal protein L36A ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr  X:133,486,403...133,488,811
Ensembl chr  X:133,486,403...133,488,811 		JBrowse link
G Rpsa ribosomal protein SA ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 9:119,956,832...119,961,435
Ensembl chr 9:119,956,755...119,961,435 		JBrowse link
G Rrm1 ribonucleotide reductase M1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 7:102,090,902...102,118,978
Ensembl chr 7:102,090,902...102,118,978 		JBrowse link
G Rrm2 ribonucleotide reductase M2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145 		JBrowse link
G Rrs1 ribosome biogenesis regulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 1:9,615,633...9,617,680
Ensembl chr 1:9,615,633...9,617,680 		JBrowse link
G Runx1 runt related transcription factor 1 ISO RGD PMID:28926105 RGD:126779571 NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037 		JBrowse link
G Satb1 special AT-rich sequence binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr17:52,043,215...52,140,318
Ensembl chr17:52,043,215...52,140,318 		JBrowse link
G Sdc1 syndecan 1 ISO mRNA:increased expression:lung (human) RGD PMID:23374247 RGD:151708716 NCBI chr12:8,821,396...8,843,716
Ensembl chr12:8,821,323...8,843,715 		JBrowse link
G Serpina3b serine (or cysteine) peptidase inhibitor, clade A, member 3B ISO protein:increased expression:cytoplasm RGD PMID:8620411 RGD:5147446 NCBI chr12:104,094,245...104,105,805
Ensembl chr12:104,094,255...104,105,804 		JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N ISO protein:increased expression:cytoplasm RGD PMID:8620411 RGD:5147446 NCBI chr12:104,372,967...104,380,588
Ensembl chr12:104,372,988...104,380,588 		JBrowse link
G Setd2 SET domain containing 2 ameliorates
exacerbates
severity		 ISO
IMP		 human cells and genes in mouse model
DNA:mutations:multiple (human)		 RGD PMID:33223508 PMID:27687306 PMID:33707235 PMID:28202515 RGD:150429633, RGD:150429649, RGD:150429648, RGD:126848875 NCBI chr 9:110,361,368...110,447,703
Ensembl chr 9:110,358,262...110,447,701 		JBrowse link
G Sfn stratifin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 4:133,327,867...133,329,163
Ensembl chr 4:133,327,867...133,329,479 		JBrowse link
G Sftpc surfactant associated protein C ISO CTD Direct Evidence: marker/mechanism CTD PMID:25851810 NCBI chr14:70,758,381...70,761,521
Ensembl chr14:70,758,389...70,761,521 		JBrowse link
G Sfxn1 sideroflexin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr13:54,225,675...54,262,365
Ensembl chr13:54,225,888...54,262,361 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 (soluble) ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr11:60,679,723...60,702,062
Ensembl chr11:60,678,930...60,702,544 		JBrowse link
G Slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr16:36,570,523...36,605,506
Ensembl chr16:36,570,539...36,605,324 		JBrowse link
G Slc19a1 solute carrier family 19 (folate transporter), member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr10:76,868,103...76,886,266
Ensembl chr10:76,868,075...76,896,836 		JBrowse link
G Slc1a5 solute carrier family 1 (neutral amino acid transporter), member 5 disease_progression ISO RGD PMID:26279756 RGD:151361150 NCBI chr 7:16,515,259...16,532,199
Ensembl chr 7:16,515,265...16,532,199 		JBrowse link
G Slc22a18 solute carrier family 22 (organic cation transporter), member 18 disease_progression ISO mRNA:increased expression:lung (human)
ClinVar Annotator: match by term: Lung adenocarcinoma		 ClinVar
RGD		 PMID:27993330 PMID:32726996 RGD:150557423 NCBI chr 7:143,027,502...143,053,071
Ensembl chr 7:143,027,473...143,053,071 		JBrowse link
G Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 disease_progression ISO RGD PMID:19171406 RGD:151361151 NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733 		JBrowse link
G Slc4a4 solute carrier family 4 (anion exchanger), member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 5:88,941,717...89,387,515
Ensembl chr 5:89,034,345...89,387,512 		JBrowse link
G Slc4a7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr14:7,669,819...7,766,808
Ensembl chr14:7,669,823...7,767,484 		JBrowse link
G Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 disease_progression ISO RGD PMID:26279756 PMID:19171406 RGD:151361150, RGD:151361151 NCBI chr 8:122,607,885...122,634,425
Ensembl chr 8:122,607,889...122,634,433 		JBrowse link
G Smad4 SMAD family member 4 ISO ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:6604412 PMID:8898652 PMID:9214508 PMID:9285566 PMID:9582123 More... NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851 		JBrowse link
G Smarcc1 SWI/SNF related BAF chromatin remodeling complex subunit C1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 9:109,961,129...110,069,773
Ensembl chr 9:109,946,776...110,069,246 		JBrowse link
G Snord22 small nucleolar RNA, C/D box 22 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr19:8,703,230...8,703,355
Ensembl chr19:8,703,230...8,703,355 		JBrowse link
G Snrpb small nuclear ribonucleoprotein B severity ISO mRNA:increased expression:lung (human) RGD PMID:22876301 RGD:10768834 NCBI chr 2:130,013,560...130,031,184
Ensembl chr 2:130,013,555...130,021,323 		JBrowse link
G Snrpe small nuclear ribonucleoprotein E severity ISO mRNA:increased expression:lung (human) RGD PMID:22876301 RGD:10768834 NCBI chr 1:133,531,609...133,538,018
Ensembl chr 1:133,531,609...133,538,029 		JBrowse link
G Snrpg small nuclear ribonucleoprotein polypeptide G ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 6:86,348,522...86,355,884
Ensembl chr 6:86,348,286...86,356,310 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882 		JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25184679 NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610 		JBrowse link
G Sox30 SRY (sex determining region Y)-box 30 disease_progression ISO RGD PMID:26330328 RGD:11535423 NCBI chr11:45,869,873...45,908,824
Ensembl chr11:45,871,137...45,908,821 		JBrowse link
G Sox4 SRY (sex determining region Y)-box 4 ISO protein:increased expression:lung RGD PMID:29882245 RGD:153297792 NCBI chr13:29,132,902...29,137,682
Ensembl chr13:29,132,902...29,137,696 		JBrowse link
G Spop speckle-type BTB/POZ protein ameliorates ISO human gene and cell line in mouse model
mRNA, protein:increased expression:lung (human)		 RGD PMID:30607139 PMID:31105033 RGD:153298920, RGD:153298927 NCBI chr11:95,304,909...95,384,236
Ensembl chr11:95,304,906...95,384,232 		JBrowse link
G Src Rous sarcoma oncogene severity ISO RGD PMID:12826049 RGD:150521546 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782 		JBrowse link
G Srm spermidine synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 4:148,675,970...148,679,076
Ensembl chr 4:148,675,960...148,679,450 		JBrowse link
G Srr serine racemase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr11:74,794,853...74,818,427
Ensembl chr11:74,797,185...74,816,774 		JBrowse link
G Srsf1 serine and arginine-rich splicing factor 1 severity ISO RGD PMID:23071587 RGD:150429662 NCBI chr11:87,937,325...87,944,583
Ensembl chr11:87,938,199...87,944,581 		JBrowse link
G Srsf2 serine and arginine-rich splicing factor 2 severity ISO RGD PMID:23071587 RGD:150429662 NCBI chr11:116,740,723...116,744,511
Ensembl chr11:116,740,727...116,743,920 		JBrowse link
G Stk11 serine/threonine kinase 11 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma		 CTD
ClinVar		 PMID:24793789 PMID:27993330 NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516 		JBrowse link
G Stk39 serine/threonine kinase 39 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 2:68,040,789...68,302,381
Ensembl chr 2:68,040,789...68,302,612 		JBrowse link
G Strbp spermatid perinuclear RNA binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 2:37,459,880...37,593,890
Ensembl chr 2:37,373,240...37,593,871 		JBrowse link
G Suclg2 succinate-Coenzyme A ligase, GDP-forming, beta subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 6:95,449,992...95,695,799
Ensembl chr 6:95,449,990...95,695,781 		JBrowse link
G Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 ISO DNA:SNP:exon:p.R213H, 638G>A (human) RGD PMID:14688021 RGD:1581441 NCBI chr 7:126,272,042...126,289,615
Ensembl chr 7:126,272,037...126,275,604 		JBrowse link
G Tert telomerase reverse transcriptase susceptibility ISO DNA:SNP: :rs2736098(human)
DNA:SNP::rs33963617(human)
DNA:SNP:: rs2736100(human)
DNA:SNPs:: rs2853669,rs2736108(human)		 RGD PMID:23738012 PMID:31935503 PMID:24761905 PMID:19955392 PMID:23908149 RGD:150530485, RGD:150530635, RGD:150530628, RGD:150530502, RGD:150530498 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Timm10 translocase of inner mitochondrial membrane 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 2:84,657,365...84,660,557
Ensembl chr 2:84,657,341...84,660,557 		JBrowse link
G Timm8a1 translocase of inner mitochondrial membrane 8A1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr  X:133,438,005...133,442,419
Ensembl chr  X:133,438,005...133,442,614 		JBrowse link
G Timp3 tissue inhibitor of metalloproteinase 3 ISO mRNA:decreased expression:lung (human) RGD PMID:23374247 RGD:151708716 NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370 		JBrowse link
G Tk1 thymidine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr11:117,706,345...117,716,913
Ensembl chr11:117,706,352...117,716,918 		JBrowse link
G Tlr4 toll-like receptor 4 ISO ClinVar Annotator: match by term: Lung adenocarcinoma ClinVar PMID:27993330 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 ISO CTD Direct Evidence: therapeutic CTD PMID:24345465 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576 		JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 7:19,435,238...19,449,370
Ensembl chr 7:19,435,238...19,449,363 		JBrowse link
G Top2a topoisomerase (DNA) II alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015 		JBrowse link
G Tpi1 triosephosphate isomerase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 6:124,787,549...124,791,121
Ensembl chr 6:124,787,549...124,791,259 		JBrowse link
G Traf4 TNF receptor associated factor 4 ISO mRNA:increased expression:lung (human) RGD PMID:29254206 RGD:151665107 NCBI chr11:78,049,249...78,056,405
Ensembl chr11:78,049,325...78,056,415 		JBrowse link
G Trf transferrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381893 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643 		JBrowse link
G Trp53 transformation related protein 53 EXP
ISO		 CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma		 CTD
ClinVar		 PMID:1565144 PMID:1631137 PMID:2046748 PMID:7732013 PMID:8423216 More... NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trp63 transformation related protein 63 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24880342 NCBI chr16:25,502,513...25,710,842
Ensembl chr16:25,502,513...25,710,852 		JBrowse link
G Ttf1 transcription termination factor, RNA polymerase I ISO CTD Direct Evidence: marker/mechanism CTD PMID:25851810 NCBI chr 2:28,950,211...28,977,668
Ensembl chr 2:28,950,274...28,977,668 		JBrowse link
G Ttr transthyretin ISO mRNA,protein:increased expression:lung (human) RGD PMID:26943652 RGD:151665207 NCBI chr18:20,797,266...20,807,383
Ensembl chr18:20,798,337...20,807,378 		JBrowse link
G Tyms thymidylate synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615 		JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 ameliorates ISO human cell line in a mouse model RGD PMID:32867711 RGD:151665200 NCBI chr15:37,966,421...38,084,103
Ensembl chr15:37,967,572...38,079,098 		JBrowse link
G Uck2 uridine-cytidine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 1:167,050,464...167,112,657
Ensembl chr 1:167,050,452...167,112,889 		JBrowse link
G Vav1 vav 1 oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:27158780 NCBI chr17:57,586,080...57,636,236
Ensembl chr17:57,586,100...57,635,031 		JBrowse link
G Wrap53 WD repeat containing, antisense to Trp53 severity ISO RGD PMID:28347242 RGD:21081522 NCBI chr11:69,452,580...69,471,076
Ensembl chr11:69,452,584...69,471,081 		JBrowse link
G Xpc xeroderma pigmentosum, complementation group C ISO CTD Direct Evidence: marker/mechanism CTD PMID:21327329 PMID:27777383 NCBI chr 6:91,466,287...91,492,870
Ensembl chr 6:91,466,287...91,492,870 		JBrowse link
G Xpo1 exportin 1 exacerbates ISO circRNA:increased expression:lung (human) RGD PMID:33268793 RGD:151665799 NCBI chr11:23,205,768...23,248,250
Ensembl chr11:23,206,055...23,248,249 		JBrowse link
G Xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 1 susceptibility
severity		 ISO DNA:missense mutation:cds: p.R399Q (human)
DNA:missense mutation:exon 10: p.R399Q (rs25487) (human)		 RGD PMID:11104903 PMID:20003463 RGD:151347406, RGD:151347422 NCBI chr 7:24,246,124...24,272,863
Ensembl chr 7:24,245,714...24,272,865 		JBrowse link
G Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr 1:72,346,576...72,434,112
Ensembl chr 1:72,346,586...72,434,111 		JBrowse link
G Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27602772 NCBI chr15:81,868,805...81,924,286
Ensembl chr15:81,872,036...81,924,286 		JBrowse link
G Zfhx3 zinc finger homeobox 3 ameliorates ISO DNA:mutations:multiple (human) RGD PMID:32653938 RGD:151361163 NCBI chr 8:109,005,975...109,688,272
Ensembl chr 8:108,669,276...109,688,262 		JBrowse link
bronchiolo-alveolar adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alx4 aristaless-like homeobox 4 ameliorates ISO RGD PMID:24037716 RGD:153344522 NCBI chr 2:93,472,779...93,511,686
Ensembl chr 2:93,472,729...93,511,684 		JBrowse link
G Ccnd1 cyclin D1 ISO protein:increased expression:lung RGD PMID:14674039 RGD:13434930 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Dnmt1 DNA methyltransferase 1 disease_progression ISO RGD PMID:19484794 RGD:4140940 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184 		JBrowse link
G Egfr epidermal growth factor receptor ISO
IMP		 DNA:snp:cds:p.T790M (human)
DNA:mutations:exons:
protein:increased expression:tumor (human)		 RGD PMID:15737014 PMID:26059825 PMID:21419590 RGD:5131465, RGD:11075076, RGD:5131630 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Egr1 early growth response 1 ISO mRNA:decreased expression:tumor (human) RGD PMID:11948124 RGD:5131942 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 ISO DNA:hypermethylation:promoter (human) RGD PMID:19484794 RGD:4140940 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog IMP DNA:mutations:cds: RGD PMID:26059825 RGD:11075076 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Mir130a microRNA 130a ISO CTD Direct Evidence: marker/mechanism CTD PMID:25926378 NCBI chr 2:84,571,459...84,571,522
Ensembl chr 2:84,571,459...84,571,522 		JBrowse link
G Mir144 microRNA 144 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25926378 NCBI chr11:77,963,831...77,963,896
Ensembl chr11:77,963,831...77,963,896 		JBrowse link
G Mir19a microRNA 19a ISO CTD Direct Evidence: marker/mechanism CTD PMID:25926378 NCBI chr14:115,281,432...115,281,513
Ensembl chr14:115,281,432...115,281,513 		JBrowse link
G Mir345 microRNA 345 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25926378 NCBI chr12:108,802,899...108,802,994
Ensembl chr12:108,802,899...108,802,994 		JBrowse link
G Mir362 microRNA 362 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25926378 NCBI chr  X:7,108,221...7,108,285
Ensembl chr  X:7,108,221...7,108,285 		JBrowse link
G Mir497 microRNA 497 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25926378 NCBI chr11:70,125,543...70,125,626
Ensembl chr11:70,125,543...70,125,626 		JBrowse link
G Trp53 transformation related protein 53 IAGP DNA:mutations:exons: RGD PMID:26059825 RGD:11075076 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16268
    disease of cellular proliferation 7720
      cancer 5669
        cell type cancer 3785
          carcinoma 3273
            adenocarcinoma 1698
              lung adenocarcinoma 331
                bronchiolo-alveolar adenocarcinoma + 14
                lung acinar adenocarcinoma 0
                lung clear cell carcinoma 0
                lung mucinous cystadenocarcinoma 0
                lung occult adenocarcinoma 0
                lung papillary adenocarcinoma 0
                mucinous lung adenocarcinoma 0
                pulmonary adenocarcinoma in situ 0
                signet ring lung adenocarcinoma 0
                solid adenocarcinoma with mucin production 0
Path 2
Term Annotations click to browse term
  disease 16268
    disease of anatomical entity 15860
      respiratory system disease 5130
        thoracic disease 3953
          Thoracic Neoplasms 1039
            Respiratory Tract Neoplasms 1036
              Lung Neoplasms 1011
                Bronchial Neoplasms 670
                  bronchus cancer 670
                    bronchus carcinoma 670
                      lung non-small cell carcinoma 632
                        lung adenocarcinoma 331
                          bronchiolo-alveolar adenocarcinoma + 14
                          lung acinar adenocarcinoma 0
                          lung clear cell carcinoma 0
                          lung mucinous cystadenocarcinoma 0
                          lung occult adenocarcinoma 0
                          lung papillary adenocarcinoma 0
                          mucinous lung adenocarcinoma 0
                          pulmonary adenocarcinoma in situ 0
                          signet ring lung adenocarcinoma 0
                          solid adenocarcinoma with mucin production 0
paths to the root