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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:pituitary adenoma
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Accession:DOID:3829 term browser browse the term
Definition:A pituitary gland benign neoplasm that derives_from glandular epithelial cells. (DO)
Synonyms:exact_synonym: Pituitary Gland Adenoma;   adenoma of the pituitary gland;   pituitary adenomas
 broad_synonym: pituitary adenoma, multiple types
 xref: EFO:0002619;   EFO:1000478;   ICDO:8272/0;   MIM:PS102200;   NCI:C3329;   ORDO:99408
For additional species annotation, visit the Alliance of Genome Resources.



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pituitary adenoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avpr1b arginine vasopressin receptor 1B ISO RGD PMID:28692683 RGD:14700668 NCBI chr13:43,046,531...43,059,046 JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IAGP RGD PMID:12036912 RGD:619590 NCBI chr 4:169,491,273...169,496,500 JBrowse link
G Cdkn1bwe cyclin-dependent kinase inhibitor 1B; white eye mutation IAGP RGD PMID:12036912 RGD:619590
G Grk2 G protein-coupled receptor kinase 2 ISO mRNA:altered expression:pituitary gland (human) RGD PMID:24169548 RGD:13792706 NCBI chr 1:211,010,259...211,031,013 JBrowse link
ACTH-secreting pituitary adenoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Pituitary adenoma, acth-secreting, somatic
CTD
ClinVar
PMID:17360484 PMID:18381572 PMID:19366855 PMID:20506337 PMID:20530095 More... NCBI chr 1:201,408,002...201,419,220 JBrowse link
G Avpr1b arginine vasopressin receptor 1B ISO RGD PMID:23884782 RGD:14700670 NCBI chr13:43,046,531...43,059,046 JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16195406 NCBI chr15:22,098,191...22,113,145 JBrowse link
G Usp8 ubiquitin specific peptidase 8 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: USP8-related condition
CTD
ClinVar
OMIM
PMID:25485838 PMID:25741868 PMID:28492532 NCBI chr 3:113,962,136...114,009,683 JBrowse link
Familial Isolated Pituitary Adenoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO ClinVar Annotator: match by term: Familial isolated pituitary adenoma ClinVar PMID:22720333 PMID:24050928 PMID:25741868 PMID:26186299 PMID:26792934 More... NCBI chr 1:201,408,002...201,419,220 JBrowse link
G Alk ALK receptor tyrosine kinase ISO ClinVar Annotator: match by term: Familial isolated pituitary adenoma ClinVar PMID:9536098 PMID:17576681 PMID:23104988 PMID:25741868 PMID:28492532 More... NCBI chr 6:28,631,431...29,351,321 JBrowse link
G Gnai2 G protein subunit alpha i2 ISO ClinVar Annotator: match by term: Familial isolated pituitary adenoma ClinVar PMID:25741868 NCBI chr 8:117,167,045...117,187,652 JBrowse link
growth hormone secreting pituitary adenoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO ClinVar Annotator: match by term: Somatotroph adenoma ClinVar PMID:2200621 PMID:5320367 PMID:9482716 PMID:9536098 PMID:12213383 More... NCBI chr 1:201,408,002...201,419,220 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO protein:increased expression:pituitary gland: RGD PMID:18981426 RGD:8662821 NCBI chr20:7,150,820...7,161,373 JBrowse link
G Gh1 growth hormone 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:1611713 PMID:2042694 NCBI chr10:91,727,883...91,729,860 JBrowse link
G Gnas GNAS complex locus ISO CTD Direct Evidence: marker/mechanism CTD PMID:11254676 NCBI chr 3:183,489,648...183,554,570 JBrowse link
G Gpr101 G protein-coupled receptor 101 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr  X:135,540,042...135,543,958 JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase ISO mRNA:decreased expression:pituitary gland RGD PMID:22580984 RGD:11667097 NCBI chr16:33,986,265...34,024,228 JBrowse link
G Men1 menin 1 ISS
ISO
OMIM:102200
ClinVar Annotator: match by term: Somatotroph adenoma
MouseDO
ClinVar
PMID:30630164 NCBI chr 1:203,638,905...203,644,871 JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:2042694 NCBI chr17:38,287,355...38,298,234 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO mRNA:increased expression:pituitary gland RGD PMID:22580984 RGD:11667097 NCBI chr13:64,714,063...64,722,320 JBrowse link
growth hormone secreting pituitary adenoma 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr101 G protein-coupled receptor 101 ISO ClinVar Annotator: match by term: GPR101-related condition | ClinVar Annotator: match by term: Pituitary adenoma, growth hormone-secreting, 2 OMIM
ClinVar
PMID:25470569 PMID:25806919 PMID:25806920 PMID:25806921 PMID:26792934 More... NCBI chr  X:135,540,042...135,543,958 JBrowse link
pituitary adenoma 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO ClinVar Annotator: match by term: PITUITARY ADENOMA 1, MULTIPLE TYPES | ClinVar Annotator: match by term: Pituitary adenoma predisposition OMIM
ClinVar
PMID:2200621 PMID:16728643 PMID:17244780 PMID:17341560 PMID:17360484 More... NCBI chr 1:201,408,002...201,419,220 JBrowse link
pituitary adenoma 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gnas GNAS complex locus ISO ClinVar Annotator: match by term: Pituitary adenoma 3, multiple types OMIM
ClinVar
PMID:1505964 PMID:1517386 PMID:1594625 PMID:1944469 PMID:2549426 More... NCBI chr 3:183,489,648...183,554,570 JBrowse link
pituitary adenoma 5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO ClinVar Annotator: match by term: Pituitary adenoma 5, multiple types ClinVar PMID:25741868 PMID:28492532 NCBI chr 1:201,408,002...201,419,220 JBrowse link
G C20h10orf105 similar to human chromosome 10 open reading frame 105 ISO ClinVar Annotator: match by term: PITUITARY ADENOMA 5, MULTIPLE TYPES | ClinVar Annotator: match by term: Pituitary adenoma 5, multiple types ClinVar PMID:11090341 PMID:11138009 PMID:12075507 PMID:12522556 PMID:15537665 More... NCBI chr20:28,333,094...28,339,341 JBrowse link
G Cdh23 cadherin-related 23 ISO ClinVar Annotator: match by term: PITUITARY ADENOMA 5, MULTIPLE TYPES | ClinVar Annotator: match by term: Pituitary adenoma 5, multiple types OMIM
ClinVar
PMID:2706105 PMID:3442652 PMID:9536098 PMID:11090341 PMID:11138009 More... NCBI chr20:28,783,124...29,165,624 JBrowse link
G Men1 menin 1 ISO ClinVar Annotator: match by term: Pituitary adenoma 5, multiple types ClinVar PMID:25741868 PMID:28492532 NCBI chr 1:203,638,905...203,644,871 JBrowse link
G Vsir V-set immunoregulatory receptor ISO ClinVar Annotator: match by term: Pituitary adenoma 5, multiple types ClinVar PMID:25741868 NCBI chr20:28,281,582...28,307,262 JBrowse link
prolactinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 IEP
ISO
protein:increased expression:pituitary gland
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:16809920 PMID:12552124 RGD:629544 NCBI chr15:22,098,191...22,113,145 JBrowse link
G Cebpd CCAAT/enhancer binding protein delta ISO
IEP
CTD Direct Evidence: marker/mechanism
protein:decreased expression:pituitary gland
CTD
RGD
PMID:21980073 PMID:21980073 RGD:7241005 NCBI chr11:84,764,670...84,765,808 JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase ISO mRNA:decreased expression:pituitary gland RGD PMID:22580984 RGD:11667097 NCBI chr16:33,986,265...34,024,228 JBrowse link
G Lrp2 LDL receptor related protein 2 ISO ClinVar Annotator: match by term: Prolactinoma ClinVar PMID:17632512 PMID:25682901 PMID:25741868 PMID:28492532 NCBI chr 3:54,189,305...54,346,769 JBrowse link
G Men1 menin 1 ISS OMIM:600634 MouseDO NCBI chr 1:203,638,905...203,644,871 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IEP mRNA:increased expression:pituitary gland (rat)
protein:increased expression:pituitary gland
RGD PMID:22635680 PMID:21980073 RGD:7240531, RGD:7241005 NCBI chr 7:95,483,105...95,488,031 JBrowse link
G Nog noggin ISO mRNA, protein:decreased expression:pituitary RGD PMID:12552124 RGD:629544 NCBI chr10:74,625,874...74,627,501 JBrowse link
G Npy5r neuropeptide Y receptor Y5 IEP protein:increased expression:pars anterior RGD PMID:11026575 RGD:1625506 NCBI chr16:23,055,427...23,063,384 JBrowse link
G Prl prolactin sexual_dimorphism IEP
ISO
IAGP
mRNA:increased expression:pituitary gland
protein:increased expression:blood serum (human)
CTD Direct Evidence: marker/mechanism
DNA:mutation
CTD
RGD
PMID:718334 PMID:1407345 PMID:3776530 PMID:9617019 PMID:17260475 More... RGD:1642576, RGD:401976454, RGD:401960111, RGD:1642576 NCBI chr17:38,287,355...38,298,234 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO mRNA:increased expression:pituitary gland RGD PMID:22580984 RGD:11667097 NCBI chr13:64,714,063...64,722,320 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19139
    disease of cellular proliferation 7890
      benign neoplasm 2221
        cell type benign neoplasm 1960
          adenoma 718
            pituitary adenoma 29
              acidophil adenoma 0
              basophil adenoma 0
              chromophobe adenoma 0
              functioning pituitary adenoma + 19
              functionless pituitary adenoma 0
              pituitary adenoma 1 1
              pituitary adenoma 3 1
              pituitary adenoma 5 5
Path 2
Term Annotations click to browse term
  disease 19139
    disease of anatomical entity 18450
      nervous system disease 14359
        Nervous System Neoplasms 1584
          Central Nervous System Neoplasms 1381
            central nervous system cancer 732
              brain cancer 715
                supratentorial cancer 507
                  diencephalic neoplasm 62
                    hypothalamic neoplasm 62
                      Pituitary Neoplasms 60
                        pituitary gland benign neoplasm 29
                          pituitary adenoma 29
                            acidophil adenoma 0
                            basophil adenoma 0
                            chromophobe adenoma 0
                            functioning pituitary adenoma + 19
                            functionless pituitary adenoma 0
                            pituitary adenoma 1 1
                            pituitary adenoma 3 1
                            pituitary adenoma 5 5
paths to the root