Shwartzman phenomenon - Ontology Report

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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Shwartzman phenomenon	go back to main search page
Accession:	DOID:3825	browse the term
Definition:	Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.
Synonyms:	exact_synonym:	Schwartzman Phenomenon; Schwartzman Reaction; Schwartzman reactions; Shwartzman reaction
	primary_id:	MESH:D012790
	xref:	GARD:7636
For additional species annotation, visit the Alliance of Genome Resources.

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Genes (2)

Shwartzman phenomenon

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

interleukin 10

RGD

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

Il6

interleukin 6

treatment

ISO

RGD

PMID:1381315

RGD:11060272

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Term paths to the root

Path 1
Term	Annotations
disease	19050
disease of anatomical entity	18384
cardiovascular system disease	5519
vascular disease	4023
vascular hemostatic disease	492
Shwartzman phenomenon	2
Path 2
Term	Annotations
disease	19050
disease of anatomical entity	18384
Hemic and Lymphatic Diseases	4041
hematopoietic system disease	3529
blood coagulation disease	1050
hemorrhagic disease	1004
vascular hemostatic disease	492
Shwartzman phenomenon	2

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RGD DISEASE ONTOLOGY - ANNOTATIONS