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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:intermittent claudication
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Accession:DOID:3669 term browser browse the term
Definition:A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
Synonyms:exact_synonym: Charcot's syndrome;   intermittent vascular claudication
 primary_id: MESH:D007383
 xref: EFO:0003876;   ICD10CM:I73.9
For additional species annotation, visit the Alliance of Genome Resources.


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intermittent claudication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agxt2 alanine-glyoxylate aminotransferase 2 ISO associated with type 2 diabetes mellitus;DNA:SNP:cds:rs2830 (human) RGD PMID:24186881 RGD:329969899 NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926 		JBrowse link
G Bad BCL2-associated agonist of cell death IEP RGD PMID:23658678 RGD:9586024 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 IEP RGD PMID:23658678 RGD:9586024 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator IEP RGD PMID:23658678 RGD:9586024 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 IEP RGD PMID:23658678 RGD:9586024 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Casp3 caspase 3 IDA RGD PMID:23658678 RGD:9586024 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Eif3e eukaryotic translation initiation factor 3 subunit E treatment IMP RGD PMID:21771896 RGD:10395378 NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096 		JBrowse link
G Epas1 endothelial PAS domain protein 1 treatment IDA RGD PMID:21771896 RGD:10395378 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Mdm2 MDM2 proto-oncogene treatment IEP RGD PMID:23658678 RGD:9586024 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Sirt2 sirtuin 2 IEP associated with Spinal Stenosis;protein:decreased expression:dorsal horn of spinal cord, ventral horn of spinal cord RGD PMID:23658678 RGD:9586024 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19137
    Pathological Conditions, Signs and Symptoms 13626
      Signs and Symptoms 11214
        intermittent claudication 10
Path 2
Term Annotations click to browse term
  disease 19137
    disease of anatomical entity 18450
      cardiovascular system disease 5544
        vascular disease 4024
          artery disease 2858
            arteriosclerosis 822
              intermittent claudication 10
paths to the root