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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:pancreatic ductal carcinoma
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Accession:DOID:3587 term browser browse the term
Definition:A pancreatic carcinoma located_in the pancreatic duct. (DO)
Synonyms:exact_synonym: Duct Cell Carcinoma of the Pancreas;   Pancreas Duct-Cell Carcinoma;   Pancreas Duct-Cell Carcinomas;   Pancreatic Ductal Carcinomas;   ductal carcinoma of the pancreas;   malignant neoplasm of duct of Wirsung;   pancreatic duct cancer;   pancreatic duct cell carcinoma
 primary_id: MESH:D021441
 xref: ICD10CM:C25.3;   ICD9CM:157.3
For additional species annotation, visit the Alliance of Genome Resources.


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pancreatic ductal carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO mRNA, protein:increased expression:pancreas RGD PMID:17481528 RGD:2325211 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 ISO protein:decreased expression:pancreas RGD PMID:19212105 RGD:2325210 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Adam8 ADAM metallopeptidase domain 8 disease_progression ISO mRNA:increased expression:pancreas RGD PMID:17979891 RGD:2325243 NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 disease_progression ISO protein:altered localization:cytoplasm RGD PMID:14997207 RGD:2325249 NCBI chr16:73,725,186...73,804,284
Ensembl chr16:67,022,655...67,100,917 		JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member ISO mRNA:increased expression:pancreas RGD PMID:19609859 RGD:2325659 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a ISO CTD Direct Evidence: marker/mechanism CTD PMID:17481528 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Alb albumin disease_progression ISO RGD PMID:19011933 RGD:2325677 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Anxa2 annexin A2 disease_progression ISO mRNA, protein:increased expression, altered localization:pancreas, plasma membrane RGD PMID:19260470 PMID:16450333 RGD:2317307, RGD:2325731 NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Anxa5 annexin A5 ISO protein:increased expression:pancreas RGD PMID:19488907 RGD:2317538 NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Anxa8 annexin A8 ISO mRNA:increased expression:pancreas RGD PMID:18223320 RGD:2325735 NCBI chr16:9,397,144...9,412,072
Ensembl chr16:9,397,113...9,412,043 		JBrowse link
G Apoc1 apolipoprotein C1 ISO RGD PMID:15876873 RGD:2325793 NCBI chr 1:88,475,018...88,479,052
Ensembl chr 1:79,346,136...79,350,375 		JBrowse link
G Arg2 arginase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23424623 NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:97,936,002...97,961,378 		JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger ISO protein:increased expression:pancreas
protein:increased expression:exocrine pancreas: 		RGD PMID:19585519 PMID:19585519 RGD:9491843, RGD:9491843 NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690 		JBrowse link
G C1h19orf33 similar to human chromosome 19 open reading frame 33 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35142956 NCBI chr 1:84,549,830...84,550,666
Ensembl chr 1:84,549,831...84,550,664 		JBrowse link
G Calr calreticulin ISO protein:increased expression:pancreatic duct RGD PMID:15289361 RGD:2326165 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Cbx7 chromobox 7 disease_progression ISO protein:decreased expression:pancreas RGD PMID:20185297 RGD:9587360 NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973 		JBrowse link
G Cckar cholecystokinin A receptor ISO mRNA:increased expression:pancreatic duct
protein:decreased expression:pancreas		 RGD PMID:9239407 PMID:12851875 RGD:4110818, RGD:4110816 NCBI chr14:61,505,270...61,513,618
Ensembl chr14:57,292,397...57,300,747 		JBrowse link
G Cckbr cholecystokinin B receptor ISO protein:decreased expression:pancreas RGD PMID:12851875 RGD:4110816 NCBI chr 1:169,183,578...169,193,583
Ensembl chr 1:159,771,733...159,814,881 		JBrowse link
G Ccnd1 cyclin D1 severity ISO protein:increased expression:pancreas (human) RGD PMID:17420962 RGD:13462063 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd40 CD40 molecule treatment ISO protein:increased expression:dendritic cell RGD PMID:21436454 PMID:23983255 PMID:20976171 RGD:5490301, RGD:11522743, RGD:5490524 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 treatment ISO human cells in a mouse model RGD PMID:24389175 RGD:13782187 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A disease_progression ISO RGD PMID:17671118 RGD:8662851 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:24986516 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cldn4 claudin 4 ISO RGD PMID:15693851 RGD:2317592 NCBI chr12:27,388,160...27,389,958
Ensembl chr12:21,751,331...21,753,436 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271 		JBrowse link
G Dnmt1 DNA methyltransferase 1 disease_progression ISO protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:29844410 PMID:19424621 RGD:9588974 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta disease_progression ISO RGD PMID:22919364 RGD:9589121 NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Dtx1 deltex E3 ubiquitin ligase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr12:35,849,647...35,880,835
Ensembl chr12:35,849,617...35,880,838 		JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 1:209,457,719...209,545,163
Ensembl chr 1:209,460,735...209,492,818 		JBrowse link
G Egf epidermal growth factor disease_progression ISO protein:increased expression: : RGD PMID:18505086 RGD:2317644 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Faslg Fas ligand ISO protein:increased expression:pancreas, liver RGD PMID:10547193 PMID:15375495 RGD:2317747, RGD:2317741 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fgf2 fibroblast growth factor 2 disease_progression ISO RGD PMID:12717266 PMID:18704599 RGD:2317758, RGD:2317756 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 disease_progression ISO protein:increased expression:pancreas RGD PMID:12109856 RGD:2317790 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211 		JBrowse link
G Gpnmb glycoprotein nmb ISO CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 resistance ISO DNA:methylation: :
mRNA, protein:increased expression:pancreas		 RGD PMID:16537562 PMID:12488200 PMID:17265526 RGD:2317809, RGD:2317811, RGD:2317806 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hdac1 histone deacetylase 1 disease_progression ISO protein:increased expression:pancreas RGD PMID:19424621 RGD:9588974 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Heatr1 HEAT repeat containing 1 treatment ISO RGD PMID:26676747 RGD:10761108 NCBI chr17:58,053,288...58,093,895
Ensembl chr17:58,051,700...58,093,948 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr11:84,210,632...84,213,045
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 1:28,641,100...28,651,187
Ensembl chr 1:26,822,131...26,832,218 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17234771 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:17234771 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO RGD PMID:20098680 RGD:2317639 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor ISO protein:increased expression:pancreas RGD PMID:14627343 PMID:14506643 RGD:2317649, RGD:2317652 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Il4 interleukin 4 ISO RGD PMID:17942922 RGD:2317264 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il4r interleukin 4 receptor ISO protein:increased expression:pancreas RGD PMID:17942922 RGD:2317264 NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Ins2 insulin 2 ISO Glucagon/insulin RGD PMID:19571666 RGD:2317248 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Jag2 jagged canonical Notch ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818 		JBrowse link
G Kdm2b lysine demethylase 2B severity ISO mRNA, protein:increased expression:pancreas (human) RGD PMID:23321669 RGD:9588253 NCBI chr12:33,566,530...33,701,366
Ensembl chr12:33,574,657...33,701,355 		JBrowse link
G Kitlg KIT ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25347530 PMID:30654191 NCBI chr 4:179,916,255...179,949,613 JBrowse link
G Krt7 keratin 7 disease_progression ISO RGD PMID:19260470 RGD:2317307 NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052 		JBrowse link
G L1cam L1 cell adhesion molecule severity ISO protein:increased expression:pancreas (human) RGD PMID:20162456 RGD:6483447 NCBI chr  X:156,748,597...156,775,116
Ensembl chr  X:151,597,277...151,623,857 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34686948 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment ISO human cells in mouse model RGD PMID:20179210 RGD:14348973 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcm7 minichromosome maintenance complex component 7 ISO mRNA, protein:increased expression:pancreatic duct RGD PMID:15548371 RGD:2317697 NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063 		JBrowse link
G Mdm2 MDM2 proto-oncogene onset
severity		 ISO DNA:snp:promoter, intron:IVS1+309T>G (human)
protein:increased expression:pancreas (human)		 RGD PMID:19752772 PMID:15810085 RGD:2317414, RGD:2317416 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Men1 menin 1 ISO protein:decreased expression:pancreas RGD PMID:19170121 RGD:2317294 NCBI chr 1:213,068,166...213,074,132
Ensembl chr 1:203,639,000...203,644,871 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO protein:increased expression:pancreatic duct (human) RGD PMID:7866999 RGD:2317530 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase susceptibility ISO DNA:missense mutation:cds:p.L84F rs12917 (human)
protein:increased activity, increased expression:ductal adenocarcinoma (human)		 RGD PMID:16844323 PMID:9393761 RGD:2317648, RGD:2317664 NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mir142 microRNA 142 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29844410 NCBI chr10:73,055,104...73,055,190
Ensembl chr10:72,557,857...72,557,967 		JBrowse link
G Mir873 microRNA 873 ISO CTD Direct Evidence: therapeutic CTD PMID:30654191 NCBI chr 5:51,356,919...51,356,995
Ensembl chr 5:51,356,919...51,356,995 		JBrowse link
G Mmp2 matrix metallopeptidase 2 severity ISO protein:increased expression:pancreas RGD PMID:17377415 RGD:2325746 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:pancreas, serum
protein:increased expression:blood		 RGD PMID:18706098 PMID:20332475 RGD:2325844, RGD:2325830 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Msln mesothelin disease_progression ISO protein:increased secretion:serum
DNA:hypomethylation:5'UTR
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:14576474 PMID:21775916 PMID:25347530 PMID:19818733 PMID:12874021 RGD:2326055, RGD:2326065 NCBI chr10:15,276,489...15,285,921
Ensembl chr10:14,771,961...14,777,643 		JBrowse link
G Muc1 mucin 1, cell surface associated disease_progression ISO protein:increased expression, altered localization:pancreas RGD PMID:14681945 PMID:18713982 PMID:19109152 RGD:2317983, RGD:2324633, RGD:2324616 NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Muc17 mucin 17, cell surface associated disease_progression ISO mRNA:increased expression:pancreas RGD PMID:12657964 RGD:2324946 NCBI chr12:19,527,251...19,536,924
Ensembl chr12:19,527,321...19,538,522 		JBrowse link
G Muc3a mucin 3A, cell surface associated disease_progression ISO mRNA:increased expression:pancreas RGD PMID:12657964 RGD:2324946 NCBI chr12:19,450,679...19,454,753
Ensembl chr12:19,446,094...19,460,522 		JBrowse link
G Muc4 mucin 4, cell surface associated disease_progression ISO mRNA:increased expression:pancreas
protein:increased expression:pancreas		 RGD PMID:12657964 PMID:16049287 RGD:2324946, RGD:2324942 NCBI chr11:68,008,245...68,053,242 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming disease_progression ISO mRNA:increased expression:pancreas RGD PMID:7657125 PMID:10227724 RGD:2324986, RGD:2324907 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming ISO mRNA:increased expression:pancreas RGD PMID:7657125 RGD:2324986 NCBI chr 1:196,916,861...196,948,830
Ensembl chr 1:196,916,825...196,949,250 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16778198 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21489257 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 ISO protein:increased expression:pancreas (human) RGD PMID:17492507 RGD:5132867 NCBI chr10:79,403,939...79,426,620
Ensembl chr10:78,906,083...78,916,408 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO RGD PMID:12660813 RGD:2325254 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Notch1 notch receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19208345 PMID:20484026 PMID:19028876 RGD:2325323, RGD:2325324 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Notch3 notch receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 7:11,783,550...11,834,585
Ensembl chr 7:11,133,706...11,184,025 		JBrowse link
G Notch4 notch receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr20:4,164,969...4,189,072
Ensembl chr20:4,160,445...4,184,465 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 disease_progression ISO protein:increased expression:pancreas RGD PMID:11295066 PMID:10209957 RGD:2325660, RGD:2325663 NCBI chr 1:141,526,192...141,913,575
Ensembl chr 1:132,132,849...132,503,286 		JBrowse link
G Osm oncostatin M ISO CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr14:83,327,202...83,332,073
Ensembl chr14:79,104,344...79,108,313 		JBrowse link
G Palld palladin, cytoskeletal associated protein ISO protein:increased expression, alternative form:pancreas, fibroblast RGD PMID:17404500 RGD:2325781 NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337 		JBrowse link
G Pax6 paired box 6 ISO protein:increased expression:pancreatic duct (human) RGD PMID:17849422 RGD:8552381 NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
G Pms1 PMS1 homolog 1, mismatch repair system component ISO protein:increased expression:pancreatic duct RGD PMID:15856462 RGD:2324870 NCBI chr 9:55,721,393...55,832,225
Ensembl chr 9:48,253,410...48,340,237 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma disease_progression ISO RGD PMID:19396032 RGD:2317461 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:18670639 RGD:2317185 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:34686948 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rnf2 ring finger protein 2 ISO protein:increased expression:pancreas RGD PMID:19585519 RGD:9491843 NCBI chr13:63,553,964...63,584,047
Ensembl chr13:63,554,862...63,583,099 		JBrowse link
G Rxra retinoid X receptor alpha severity ISO RGD PMID:19396032 RGD:2317461 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Serpina1 serpin family A member 1 ISO mRNA, protein:increased expression:pancreas RGD PMID:12488200 RGD:2317811 NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:122,866,312...122,888,339 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 ISO protein:increased expression:pancreatic duct RGD PMID:19252908 RGD:2324975 NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Smad4 SMAD family member 4 disease_progression ISO RGD PMID:15173084 RGD:21066334 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Smo smoothened, frizzled class receptor ISO RGD PMID:16826192 RGD:2324981 NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Stk11 serine/threonine kinase 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26887594 NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 disease_progression ISO RGD PMID:16101174 RGD:2325019 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 disease_progression ISO mRNA:increased expresssion:pancreas RGD PMID:17114585 PMID:10547197 RGD:2317498, RGD:2317500 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Thbs1 thrombospondin 1 disease_progression ISO DNA:hypermethylation:promoter (human) RGD PMID:12429967 PMID:19065635 RGD:2325025, RGD:2325022 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Tmprss3 transmembrane serine protease 3 ISO RGD PMID:14695172 RGD:2325152 NCBI chr20:9,254,102...9,273,808
Ensembl chr20:9,254,109...9,274,363 		JBrowse link
G Tp53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29844410 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tsc2 TSC complex subunit 2 severity ISO RGD PMID:16213898 RGD:11568674 NCBI chr10:14,125,679...14,160,317
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Tymp thymidine phosphorylase disease_progression ISO RGD PMID:19760965 RGD:2325155 NCBI chr 7:122,318,396...122,323,716
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17481528 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor ISO DNA:hypermethylation:promoter (human) RGD PMID:19065635 RGD:2325022 NCBI chr 4:148,328,099...148,334,992
Ensembl chr 4:146,772,468...146,779,377 		JBrowse link
G Yeats2 YEATS domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34686948 NCBI chr11:80,743,134...80,829,253
Ensembl chr11:80,743,134...80,829,208 		JBrowse link
G Zzz3 zinc finger, ZZ-type containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34686948 NCBI chr 2:241,330,366...241,397,308
Ensembl chr 2:241,331,022...241,397,307 		JBrowse link
pancreatic adenosquamous carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb2 transforming growth factor, beta 2 ameliorates ISO human cells in a mouse model RGD PMID:21366804 RGD:155630611 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
pancreatic ductal adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member ISO protein:increased expression:pancreas RGD PMID:19714807 RGD:2325658 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 ISO protein:increased expression:pancreas RGD PMID:19077459 RGD:2325696 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909 		JBrowse link
G Calr calreticulin ameliorates ISO human cells in mouse model
human cells in a mouse model		 RGD PMID:33028359 PMID:29072694 RGD:150520160, RGD:150521706 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Ccnd1 cyclin D1 severity ISO DNA:snp:exon:c.870G>A (human)
protein:increased expression:pancreas (human)		 RGD PMID:25470788 PMID:22939953 RGD:13462050, RGD:13462062 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd59b CD59b molecule disease_progression ISO protein:increased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 severity ISO protein:increased expression:pancreas, islet of Langerhans (human) RGD PMID:29735403 RGD:13781899 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G E2f1 E2F transcription factor 1 severity ISO protein:increased expression:pancreatic ductal cell, nucleus (human)
DNA:amplification: : (human)		 RGD PMID:12650514 PMID:17233815 PMID:27573434 RGD:13838735, RGD:13838739, RGD:13838738 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Foxm1 forkhead box M1 disease_progression ISO RGD PMID:24859161 RGD:156430321 NCBI chr 4:163,325,628...163,338,100
Ensembl chr 4:161,638,816...161,650,684 		JBrowse link
G Fubp1 far upstream element binding protein 1 ISO mRNA:increased expression:pancreatic duct (human) RGD PMID:32481602 RGD:151361197 NCBI chr 2:243,819,529...243,846,544
Ensembl chr 2:241,159,512...241,186,602 		JBrowse link
G Glipr2 GLI pathogenesis-related 2 disease_progression ISO protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 5:58,170,417...58,202,258
Ensembl chr 5:58,170,425...58,202,272 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 treatment ISO human cells in a mouse model RGD PMID:23535601 RGD:13504844 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 disease_progression ISO protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta susceptibility ISO RGD PMID:22264792 RGD:13838741 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Jak1 Janus kinase 1 ISO mRNA:decreased expression:pancreatic ductal cell (human) RGD PMID:28677798 RGD:13838745 NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 severity
disease_progression		 ISO protein:increased phosphorylation:pancreas (mouse) RGD PMID:28837246 PMID:23237571 RGD:14348974, RGD:14348975 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mir155 microRNA 155 disease_progression ISO RGD PMID:28198398 RGD:25314300 NCBI chr11:37,261,114...37,261,178
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir494 microRNA 494 disease_progression
ameliorates		 ISO RGD PMID:24859161 PMID:24859161 RGD:156430321, RGD:156430321 NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793 		JBrowse link
G Pgf placental growth factor severity ISO associated with obesity RGD PMID:26861455 RGD:14349030 NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:104,816,104...104,826,685 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO mRNA, protein:increased expression:pancreas (human) RGD PMID:20876794 RGD:14390130 NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 severity ISO human cells in a mouse model RGD PMID:15591514 RGD:14390084 NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pld1 phospholipase D1 severity ISO protein:increased expression:pancreas (human) RGD PMID:27713167 RGD:14392801 NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Ptprb protein tyrosine phosphatase, receptor type, B disease_progression ISO protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 7:51,953,375...52,034,751
Ensembl chr 7:51,930,015...52,034,748 		JBrowse link
G Ptprm protein tyrosine phosphatase, receptor type, M disease_progression ISO protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 9:106,639,573...107,343,698
Ensembl chr 9:106,639,573...107,343,698 		JBrowse link
G Rac1 Rac family small GTPase 1 ISO mRNA:increased expression:pancreas (human)
mRNA, protein:increased expression:pancreas (mouse)		 RGD PMID:23334332 PMID:21684285 RGD:14392806, RGD:14392816 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rala RAS like proto-oncogene A ISO mRNA:increased expression:pancreas (human) RGD PMID:29113235 RGD:14394418 NCBI chr17:51,787,682...51,840,738
Ensembl chr17:47,092,207...47,144,063 		JBrowse link
G S100a8 S100 calcium binding protein A8 disease_progression ISO protein:increased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G Smad2 SMAD family member 2 severity ISO RGD PMID:26908446 RGD:14394493 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ameliorates ISO protein:decreased expression:pancreas (human) RGD PMID:8253361 RGD:155630628 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 ameliorates ISO protein:decreased expression:pancreas (human) RGD PMID:8253361 RGD:155630628 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 ameliorates ISO protein:decreased expression:pancreas (human) RGD PMID:8253361 RGD:155630628 NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ameliorates ISO human cell line in a mouse model RGD PMID:17297450 RGD:155630637 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Vegfd vascular endothelial growth factor D ISO protein:increased expression:blood serum (human) RGD PMID:21410412 RGD:155630646 NCBI chr  X:33,704,582...33,740,305
Ensembl chr  X:30,074,163...30,108,295 		JBrowse link
G Vnn1 vanin 1 disease_progression ISO protein:increased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19134
    disease of cellular proliferation 7891
      Neoplasms by Histologic Type 5346
        Glandular and Epithelial Neoplasms 3800
          carcinoma 3273
            pancreatic carcinoma 179
              pancreatic ductal carcinoma 134
                pancreatic ductal adenocarcinoma + 33
Path 2
Term Annotations click to browse term
  disease 19134
    disease of cellular proliferation 7891
      cancer 5722
        organ system cancer 5469
          endocrine gland cancer 2612
            pancreatic cancer 421
              malignant exocrine pancreas neoplasm 180
                pancreatic carcinoma 179
                  pancreatic ductal carcinoma 134
                    pancreatic ductal adenocarcinoma + 33
paths to the root