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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:pancreatic ductal adenocarcinoma
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Accession:DOID:3498 term browser browse the term
Definition:A pancreatic adenocarcinoma that derives_from pancreatic duct cells. (DO)
Synonyms:exact_synonym: PDAC;   ductal adenocarcinoma of the pancreas;   pancreatic tubular adenocarcinoma
 narrow_synonym: Undifferentiated Pancreatic Carcinoma
 alt_id: RDO:9002823
 xref: EFO:0002517;   EFO:0006471;   EFO:1000606;   NCI:C34041;   NCI:C9120
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
pancreatic ductal adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2 ISO protein:increased expression:pancreas RGD PMID:19714807 RGD:2325658 NCBI chr12:36,042,924...36,054,080
Ensembl chr12:36,042,906...36,054,086 		JBrowse link
G Akr7a5 aldo-keto reductase family 7, member A5 ISO protein:increased expression:pancreas RGD PMID:19077459 RGD:2325696 NCBI chr 4:139,038,005...139,046,097
Ensembl chr 4:139,038,055...139,045,737 		JBrowse link
G Calr calreticulin ameliorates ISO human cells in mouse model
human cells in a mouse model		 RGD PMID:33028359 PMID:29072694 RGD:150520160, RGD:150521706 NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563 		JBrowse link
G Ccnd1 cyclin D1 severity ISO DNA:snp:exon:c.870G>A (human)
protein:increased expression:pancreas (human)		 RGD PMID:25470788 PMID:22939953 RGD:13462050, RGD:13462062 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cd59b CD59b antigen disease_progression ISO protein:increased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 2:103,900,127...103,920,619
Ensembl chr 2:103,896,142...103,921,534 		JBrowse link
G Cdk4 cyclin dependent kinase 4 severity ISO protein:increased expression:pancreas, islet of Langerhans (human) RGD PMID:29735403 RGD:13781899 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789 		JBrowse link
G Cfhr2 complement factor H-related 2 disease_progression ISO protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 1:139,738,030...139,786,437
Ensembl chr 1:139,731,905...139,786,456 		JBrowse link
G E2f1 E2F transcription factor 1 severity ISO protein:increased expression:pancreatic ductal cell, nucleus (human)
DNA:amplification: : (human)		 RGD PMID:12650514 PMID:17233815 PMID:27573434 RGD:13838735, RGD:13838739, RGD:13838738 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G Foxm1 forkhead box M1 disease_progression ISO RGD PMID:24859161 RGD:156430321 NCBI chr 6:128,339,957...128,352,849
Ensembl chr 6:128,339,930...128,353,109 		JBrowse link
G Fubp1 far upstream element (FUSE) binding protein 1 ISO mRNA:increased expression:pancreatic duct (human) RGD PMID:32481602 RGD:151361197 NCBI chr 3:151,916,059...151,942,467
Ensembl chr 3:151,916,059...151,942,463 		JBrowse link
G Glipr2 GLI pathogenesis-related 2 disease_progression ISO protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 4:43,957,702...43,979,118
Ensembl chr 4:43,957,401...43,979,118 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1, soluble treatment ISO human cells in a mouse model RGD PMID:23535601 RGD:13504844 NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044 		JBrowse link
G Hspa8 heat shock protein 8 disease_progression ISO protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta susceptibility IMP RGD PMID:22264792 RGD:13838741 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Jak1 Janus kinase 1 ISO mRNA:decreased expression:pancreatic ductal cell (human) RGD PMID:28677798 RGD:13838745 NCBI chr 4:101,009,171...101,122,493
Ensembl chr 4:101,009,564...101,122,479 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 severity
disease_progression		 IMP
IEP		 protein:increased phosphorylation:pancreas (mouse) RGD PMID:28837246 PMID:23237571 RGD:14348974, RGD:14348975 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mir155 microRNA 155 disease_progression ISO RGD PMID:28198398 RGD:25314300 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mir494 microRNA 494 disease_progression
ameliorates		 ISO RGD PMID:24859161 PMID:24859161 RGD:156430321, RGD:156430321 NCBI chr12:109,681,752...109,681,836
Ensembl chr12:109,681,752...109,681,836 		JBrowse link
G Pgf placental growth factor severity IMP associated with obesity RGD PMID:26861455 RGD:14349030 NCBI chr12:85,213,413...85,224,087
Ensembl chr12:85,213,409...85,224,564 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO mRNA, protein:increased expression:pancreas (human) RGD PMID:20876794 RGD:14390130 NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 severity ISO human cells in a mouse model RGD PMID:15591514 RGD:14390084 NCBI chr 8:71,220,820...71,229,356
Ensembl chr 8:71,220,820...71,229,357 		JBrowse link
G Pld1 phospholipase D1 severity ISO protein:increased expression:pancreas (human) RGD PMID:27713167 RGD:14392801 NCBI chr 3:27,992,636...28,187,388
Ensembl chr 3:27,992,844...28,187,511 		JBrowse link
G Ptprb protein tyrosine phosphatase receptor type B disease_progression ISO protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr10:116,111,407...116,225,443
Ensembl chr10:116,111,428...116,225,440 		JBrowse link
G Ptprm protein tyrosine phosphatase receptor type M disease_progression ISO protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr17:66,973,843...67,661,486
Ensembl chr17:66,973,942...67,661,452 		JBrowse link
G Rac1 Rac family small GTPase 1 ISO
IEP		 mRNA:increased expression:pancreas (human)
mRNA, protein:increased expression:pancreas (mouse)		 RGD PMID:23334332 PMID:21684285 RGD:14392806, RGD:14392816 NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791 		JBrowse link
G Rala v-ral simian leukemia viral oncogene A (ras related) ISO mRNA:increased expression:pancreas (human) RGD PMID:29113235 RGD:14394418 NCBI chr13:18,055,160...18,118,802
Ensembl chr13:18,055,156...18,118,824 		JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) disease_progression ISO protein:increased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342 		JBrowse link
G Smad2 SMAD family member 2 severity ISO RGD PMID:26908446 RGD:14394493 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ameliorates ISO protein:decreased expression:pancreas (human) RGD PMID:8253361 RGD:155630628 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 ameliorates ISO protein:decreased expression:pancreas (human) RGD PMID:8253361 RGD:155630628 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 ameliorates ISO protein:decreased expression:pancreas (human) RGD PMID:8253361 RGD:155630628 NCBI chr12:86,103,517...86,125,815
Ensembl chr12:86,103,519...86,125,815 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor I ameliorates ISO human cell line in a mouse model RGD PMID:17297450 RGD:155630637 NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931 		JBrowse link
G Vegfd vascular endothelial growth factor D ISO protein:increased expression:blood serum (human) RGD PMID:21410412 RGD:155630646 NCBI chr  X:163,156,282...163,185,643
Ensembl chr  X:163,156,374...163,185,646 		JBrowse link
G Vnn1 vanin 1 disease_progression ISO protein:increased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr10:23,770,586...23,781,242
Ensembl chr10:23,770,586...23,781,241 		JBrowse link
pancreatic adenosquamous carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb2 transforming growth factor, beta 2 ameliorates ISO human cells in a mouse model RGD PMID:21366804 RGD:155630611 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16268
    disease of cellular proliferation 7720
      Neoplasms by Histologic Type 5312
        Glandular and Epithelial Neoplasms 3807
          Ductal, Lobular, and Medullary Neoplasms 281
            Ductal Carcinoma 269
              pancreatic ductal carcinoma 134
                pancreatic ductal adenocarcinoma 34
                  colloid carcinoma of the pancreas 0
                  mixed ductal-endocrine carcinoma 0
                  osteoclast-like giant cell neoplasm of the pancreas 0
                  pancreatic adenosquamous carcinoma 1
                  pancreatic signet ring cell adenocarcinoma 0
Path 2
Term Annotations click to browse term
  disease 16268
    disease of cellular proliferation 7720
      Neoplasms by Site 7164
        Digestive System Neoplasms 3838
          Pancreatic Neoplasms 425
            pancreatic cancer 422
              malignant exocrine pancreas neoplasm 180
                pancreatic carcinoma 179
                  pancreatic ductal carcinoma 134
                    pancreatic ductal adenocarcinoma 34
                      colloid carcinoma of the pancreas 0
                      mixed ductal-endocrine carcinoma 0
                      osteoclast-like giant cell neoplasm of the pancreas 0
                      pancreatic adenosquamous carcinoma 1
                      pancreatic signet ring cell adenocarcinoma 0
paths to the root