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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:brain infarction
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Accession:DOID:3454 term browser browse the term
Definition:A cerebrovascular disease that is characterized by tissue necrosis located_in the brain, resulting from inadequate blood flow through the brain. (DO)
Synonyms:exact_synonym: Anterior Cerebral Circulation Infarction;   Anterior Circulation Brain Infarction;   Brain Venous Infarction;   Brain Venous Infarctions;   brain infarctions;   posterior circulation brain infarction
 narrow_synonym: MRI defined brain infarct
 primary_id: MESH:D020520
 xref: EFO:0004277;   EFO:0004715
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
brain infarction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing IDA RGD PMID:19362080 RGD:5686830 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adk adenosine kinase ISO
IMP
RGD PMID:16685255 PMID:9731623 RGD:6482657, RGD:6482667 NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510
JBrowse link
G Adm adrenomedullin treatment ISO RGD PMID:21695352 RGD:5508764 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Adnp activity-dependent neuroprotector homeobox IDA RGD PMID:11935065 RGD:1358226 NCBI chr 3:156,886,921...156,921,500
Ensembl chr 3:156,891,381...156,917,312
JBrowse link
G Aif1 allograft inflammatory factor 1 IEP
ISO
protein:increased expression:brain subventricular zone (rat)
protein:increased expression:brain white matter (human)
RGD PMID:19053043 PMID:10683518 RGD:2313025, RGD:2313026 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member susceptibility ISO RGD PMID:17388993 RGD:1601161 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein ISO associated with Metabolic Syndrome X; DNA:polymorphism:g.162A>C rs4769055 (human) RGD PMID:18506375 RGD:2311309 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
JBrowse link
G Arrb2 arrestin, beta 2 IEP protein:increased expression:spleen RGD PMID:29636059 RGD:401938621 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 IEP mRNA:decreased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665
JBrowse link
G Becn1 beclin 1 IEP protein:increased expression:brain RGD PMID:22227058 RGD:6483057 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 IEP mRNA:decreased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
JBrowse link
G Calcrl calcitonin receptor like receptor IEP mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910
JBrowse link
G Cd8a CD8 subunit alpha IEP mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040
JBrowse link
G Cfh complement factor H treatment ISO RGD PMID:21695352 RGD:5508764 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Cort cortistatin IEP mRNA:decreased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 5:159,560,591...159,562,032 JBrowse link
G Ctsb cathepsin B IEP protein:increased expression:cerebral cortical segment, cytoplasm (rat) RGD PMID:19941836 RGD:2315502 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 IEP protein:increased expression:brain (rat) RGD PMID:19895873 RGD:2325193 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cybb cytochrome b-245 beta chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:19417757 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 IEP mRNA:decreased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278
JBrowse link
G Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1 ISO DNA:variants:CDS:multiple (human) RGD PMID:36762557 RGD:401901151 NCBI chr 1:168,749,302...168,798,079
Ensembl chr 1:168,751,038...168,797,759
JBrowse link
G Dcx doublecortin IEP protein:altered expression:brain (rat) RGD PMID:12161747 RGD:155630606 NCBI chr  X:107,430,767...107,573,612
Ensembl chr  X:107,430,767...107,507,476
JBrowse link
G Ece1 endothelin converting enzyme 1 ISO RGD PMID:15485550 RGD:1580908 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
JBrowse link
G Fgf2 fibroblast growth factor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:17524524 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Gpnmb glycoprotein nmb IEP mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
JBrowse link
G Gpr17 G protein-coupled receptor 17 ISO CTD Direct Evidence: therapeutic CTD PMID:18974869 NCBI chr18:23,576,232...23,583,153
Ensembl chr18:23,577,242...23,582,966
JBrowse link
G Gzmb granzyme B IEP protein:increased expression:brain (rat) RGD PMID:19895873 RGD:2325193 NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
JBrowse link
G Hgf hepatocyte growth factor treatment IDA RGD PMID:16421510 RGD:8548626 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha exacerbates IMP RGD PMID:30052311 RGD:155663378 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmgb1 high mobility group box 1 IMP RGD PMID:19944723 RGD:2316741 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565
JBrowse link
G Hnmt histamine N-methyltransferase severity IMP RGD PMID:21131122 PMID:16330002 RGD:5509772, RGD:5509773 NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B IEP mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 9:86,735,793...86,756,638
Ensembl chr 9:86,742,102...86,755,108
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:serum RGD PMID:18692933 RGD:2313474 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Igf2 insulin-like growth factor 2 IEP mRNA, protein:increased expression:brain RGD PMID:7770004 RGD:5509999 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Il15 interleukin 15 ISO associated with Hypertension;protein:increased expression:serum RGD PMID:16109314 RGD:1626610 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il1b interleukin 1 beta IEP protein:increased expression:cerebral cortex (rat) RGD PMID:17678971 RGD:1626644 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 IEP protein:increased expression:brain (rat) RGD PMID:19895873 RGD:2325193 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Kcnk6 potassium two pore domain channel subfamily K member 6 IEP mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 1:84,525,613...84,533,948
Ensembl chr 1:84,525,590...84,534,677
JBrowse link
G Mdk midkine IDA RGD PMID:15450683 RGD:1582478 NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130
JBrowse link
G Meis2 Meis homeobox 2 IEP protein:altered expression:brain (rat) RGD PMID:12161747 RGD:155630606 NCBI chr 3:102,742,904...102,944,833
Ensembl chr 3:102,742,900...102,949,696
JBrowse link
G Mgp matrix Gla protein IEP mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
JBrowse link
G Mir223 microRNA 223 IEP RNA:increased expression:brain,blood RGD PMID:31342956 RGD:25824952 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996
JBrowse link
G Mmp14 matrix metallopeptidase 14 IEP mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp8 matrix metallopeptidase 8 IEP mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:16599837 RGD:1582617 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Msi1 musashi RNA-binding protein 1 IEP RGD PMID:15250238 RGD:1582664 NCBI chr12:41,158,301...41,251,134
Ensembl chr12:41,158,599...41,191,076
JBrowse link
G Nes nestin IEP associated with Hypertension RGD PMID:16321245 RGD:1642069 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Parg poly (ADP-ribose) glycohydrolase IMP associated with Reperfusion Injury RGD PMID:12834903 RGD:2316742 NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273
JBrowse link
G Pbx1 PBX homeobox 1 IEP protein:altered expression:brain (rat) RGD PMID:12161747 RGD:155630606 NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594
JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: therapeutic CTD PMID:16190367 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B IEP protein:altered expression:brain (rat) RGD PMID:12161747 RGD:155630606 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
JBrowse link
G Prcp prolylcarboxypeptidase IEP mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 1:146,931,487...146,983,891
Ensembl chr 1:146,930,561...146,984,530
JBrowse link
G Rbfox3 RNA binding fox-1 homolog 3 IEP protein:altered expression:brain (rat) RGD PMID:12161747 RGD:155630606 NCBI chr10:103,720,355...104,157,277
Ensembl chr10:103,720,636...104,156,935
JBrowse link
G RT1-Ba RT1 class II, locus Ba ISO DNA:polymorphisms (human) RGD PMID:11798899 RGD:5147807 NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 IEP mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 3:51,335,841...51,438,308
Ensembl chr 3:51,335,841...51,438,256
JBrowse link
G Sirt1 sirtuin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22878646 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Tbxas1 thromboxane A synthase 1 IDA RGD PMID:14650360 RGD:1601455 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
JBrowse link
G Tnf tumor necrosis factor IEP protein:increased expression:brain (rat) RGD PMID:19895873 RGD:2325193 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tpcn2 two pore segment channel 2 IEP mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 1:200,416,538...200,446,252
Ensembl chr 1:200,416,540...200,446,236
JBrowse link
Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htra1 HtrA serine peptidase 1 ISO ClinVar Annotator: match by term: CARASIL | ClinVar Annotator: match by term: CARASIL syndrome | ClinVar Annotator: match by term: Cerebrovascular disease with thin skin, alopecia, and disc disease | ClinVar Annotator: match by term: HTRA1-related cerebral small vessel disease OMIM
ClinVar
PMID:11889251 PMID:18316707 PMID:19387015 PMID:20437615 PMID:21115960 More... NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379
JBrowse link
G Pura purine rich element binding protein A ISO ClinVar Annotator: match by term: Cerebrovascular disease with thin skin, alopecia, and disc disease ClinVar PMID:24500651 PMID:27148565 NCBI chr18:27,885,071...27,905,509
Ensembl chr18:27,884,556...27,905,513
JBrowse link
cerebral infarction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin disease_progression ISO RGD PMID:28266892 RGD:13702087 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Ace angiotensin I converting enzyme ISO DNA:deletion:intron:IVS16+1464-1751del (human)
ClinVar Annotator: match by term: Ischemic stroke, susceptibility to
ClinVar
RGD
PMID:1313972 PMID:1319114 PMID:1328889 PMID:1386652 PMID:1976655 More... RGD:11038922 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Adora1 adenosine A1 receptor IDA RGD PMID:17067559 RGD:1625229 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO protein:increased expression:plasma RGD PMID:23288172 RGD:8696004 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Agxt2 alanine-glyoxylate aminotransferase 2 onset ISO DNA:missense mutation:cds:V498L (rs16899974) (human) RGD PMID:26984639 RGD:329961314 NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926
JBrowse link
G Ahsp alpha hemoglobin stabilizing protein ISO mRNA:increased expression:venous blood (human) RGD PMID:29284304 RGD:329961296 NCBI chr 1:182,879,901...182,885,508
Ensembl chr 1:182,880,076...182,885,506
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein susceptibility ISO OMIM NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
JBrowse link
G Ang angiogenin severity ISO protein:increased expression:serum RGD PMID:17823536 RGD:6892714 NCBI chr15:24,312,711...24,323,361 JBrowse link
G Anxa1 annexin A1 treatment IEP associated with Ischemic Attack, Transient RGD PMID:22617647 RGD:7483559 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Apoa5 apolipoprotein A5 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :-1131T>C (human) RGD PMID:19107359 RGD:2313314 NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
JBrowse link
G Apob apolipoprotein B ISO protein:increased expression:serum RGD PMID:2352345 RGD:2313973 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoe apolipoprotein E susceptibility ISO DNA:polymorphism: :3932T>C (human) RGD PMID:17016617 RGD:1601237 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase susceptibility ISO DNA:SNPs,haplotypes:multiple RGD PMID:20458436 RGD:401794454 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
JBrowse link
G Brinp3 BMP/retinoic acid inducible neural specific 3 ISO associated with diabetes mellitus;mRNA:protein:increased expression:blood mononuclear cell: RGD PMID:26717922 RGD:14398486 NCBI chr13:58,413,883...58,846,828
Ensembl chr13:58,413,883...58,846,770
JBrowse link
G Cbs cystathionine beta synthase susceptibility ISO DNA:SNPs,haplotypes:multiple RGD PMID:20458436 RGD:401794454 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment ISO RGD PMID:29111308 RGD:155260331 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 treatment ISO RGD PMID:29111308 RGD:155260331 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO RGD PMID:23602964 RGD:8552262 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Cd36 CD36 molecule ISO associated with Hyperlipidemias RGD PMID:22718544 RGD:6893487 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Ephx2 epoxide hydrolase 2 IDA RGD PMID:16306811 RGD:1580986 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G F2 coagulation factor II, thrombin ISO ClinVar Annotator: match by term: Ischemic stroke | ClinVar Annotator: match by term: Ischemic stroke, susceptibility to ClinVar
OMIM
PMID:2222810 PMID:2429850 PMID:2825773 PMID:6305407 PMID:8696333 More... NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F5 coagulation factor V susceptibility ISO ClinVar Annotator: match by term: Ischemic stroke, susceptibility to ClinVar
OMIM
PMID:7586244 PMID:7803250 PMID:7877648 PMID:7910348 PMID:7911872 More... NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317
JBrowse link
G F7 coagulation factor VII treatment ISO protein:increased expression, increased activity:plasma (human)
human protein in a mouse model
RGD PMID:14733777 PMID:21998055 RGD:11049518, RGD:11049520 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Fbn1 fibrillin 1 ISO ClinVar Annotator: match by term: Ischemic stroke ClinVar PMID:7611299 PMID:8894692 PMID:9401003 PMID:9536098 PMID:10533071 More... NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Folh1 folate hydrolase 1 susceptibility ISO DNA:SNPs,haplotypes:multiple RGD PMID:20458436 RGD:401794454 NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379
JBrowse link
G Gch1 GTP cyclohydrolase 1 exacerbates
treatment
ISO
IMP
DNA:SNP:3' UTR:+243C>T (human)
DNA:SNP, haplotype:rs841 (human)
RGD PMID:21181356 PMID:16282548 PMID:21963893 RGD:329961322, RGD:329961574, RGD:329961572 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
JBrowse link
G Gp6 glycoprotein VI ameliorates ISO RGD PMID:34237320 RGD:401794450 NCBI chr 1:69,429,232...69,492,709
Ensembl chr 1:69,465,789...69,491,326
JBrowse link
G Gpx3 glutathione peroxidase 3 susceptibility ISO DNA, protein:SNP,decreased expression:promoter,plasma:-861A>T (human)
DNA:SNPs, haplotypes:promoter:rs8177412, rs870407, rs870406 (human)
DNA:SNPs, haplotype:promoter:-942 A>C, -927 T>C, -861 A>T, -302 A>T, -284 T>A, -568 T>C, -518 T>C, -65 T>C (human)
RGD PMID:25126700 PMID:20946167 PMID:17122425 RGD:401827128, RGD:401827165, RGD:401827163 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 severity ISO RGD PMID:23723305 RGD:13792693 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grn granulin precursor ISO ClinVar Annotator: match by term: Ischemic stroke ClinVar PMID:18723524 PMID:25741868 PMID:28492532 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
JBrowse link
G Gsn gelsolin severity ISO protein:decreased expression:blood plasma (human) RGD PMID:21481565 RGD:329337334 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G H19 H19 imprinted maternally expressed transcript disease_progression
susceptibility
ameliorates
ISO RNA:increased expression:blood plasma, plasma exosome (human)
DNA:SNP::(rs217727) (human)
DNA:SNPs,haplotypes: (rs217727,rs4929984) (human)
associated with atherosclerosis
RGD PMID:36453417 PMID:33541284 PMID:28203482 PMID:30778327 PMID:36453417 RGD:155882574, RGD:156430336, RGD:155900760, RGD:155900761, RGD:155882574 NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:1634355 NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
Ensembl chr10:15,307,815...15,338,392
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha severity ISO protein:increased expression:blood serum (human) RGD PMID:34708885 RGD:155260326 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmgb1 high mobility group box 1 ISO protein:increased expression:plasma RGD PMID:23288172 RGD:8696004 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565
JBrowse link
G Hmox1 heme oxygenase 1 ISO RGD PMID:23311871 RGD:10755574 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnf1a HNF1 homeobox A susceptibility ISO DNA:SNPs,haplotypes:multiple RGD PMID:28035729 RGD:329901837 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP mRNA, protein:increased expression:cerebral cortex RGD PMID:20083630 RGD:8547724 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifnb1 interferon beta 1 susceptibility
no_association
ISO
IDA
DNA:SNP,haplotype: rs9333358(human) RGD PMID:31810024 PMID:16514094 RGD:401851921, RGD:401854228 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:29111308 RGD:155260331 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il18 interleukin 18 treatment IEP RGD PMID:20584315 RGD:8655991 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta treatment ISO RGD PMID:29111308 RGD:155260331 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 treatment ISO RGD PMID:29111308 RGD:155260331 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf8 interferon regulatory factor 8 exacerbates ISO RGD PMID:24528256 RGD:329902074 NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829
JBrowse link
G Itga9 integrin subunit alpha 9 susceptibility ISO DNA:SNPs,haplotype:rs189897,rs2212020(human) RGD PMID:21764681 RGD:13602007 NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754
JBrowse link
G Itgam integrin subunit alpha M ISO protein:increased expression:neutrophil (human) RGD PMID:31355307 RGD:329901831 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Kalrn kalirin, RhoGEF kinase susceptibility
sexual_dimorphism
ISO DNA:SNP:intron: (rs6438833) (human)
DNA:SNPs, haplotypes:intron,cds: (rs7620580, rs1708303) (human)
RGD PMID:25917671 PMID:28706949 RGD:11085239, RGD:329956420 NCBI chr11:66,198,155...66,803,166
Ensembl chr11:66,198,173...66,797,610
JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 ameliorates ISO RGD PMID:29037241 RGD:329969881 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
JBrowse link
G Lipg lipase G, endothelial type susceptibility ISO DNA:polymorphism: :584C>T (human) RGD PMID:17016617 RGD:1601237 NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
JBrowse link
G Lta lymphotoxin alpha ISO RGD PMID:14593215 RGD:1580416 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
JBrowse link
G Map2 microtubule-associated protein 2 IDA RGD PMID:22444278 RGD:6483079 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 treatment IMP RGD PMID:23968852 RGD:10412642 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Mir145 microRNA 145 ameliorates ISO miRNA:increased expression:blood (human) RGD PMID:22370881 PMID:26722607 RGD:155260291, RGD:155260295 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727
JBrowse link
G Mir21 microRNA 21 IEP RNA:increased expression:brain RGD PMID:20840605 RGD:41410884 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir210 microRNA 210 severity
treatment
ISO miRNA:decreased expression:blood (human)
miRNA:decreased expression:blood serum (human)
RGD PMID:21622133 PMID:29111308 PMID:34708885 RGD:155260318, RGD:155260331, RGD:155260326 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454
JBrowse link
G Mir223 microRNA 223 treatment IEP RGD PMID:28469772 RGD:35668865 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996
JBrowse link
G Mir30a microRNA 30a treatment IEP RGD PMID:28469772 RGD:35668865 NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670
JBrowse link
G Mir383 microRNA 383 treatment IEP RGD PMID:28469772 RGD:35668865 NCBI chr16:54,040,340...54,040,413
Ensembl chr16:54,040,340...54,040,413
JBrowse link
G Mir494 microRNA 494 disease_progression ISO RGD PMID:32239566 RGD:155883173 NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16846501 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16846501 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II ISO ClinVar Annotator: match by term: Ischemic stroke ClinVar NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b ISO ClinVar Annotator: match by term: Ischemic stroke ClinVar NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO DNA:transition:cds:g.677C>T (human) RGD PMID:10929044 RGD:1580590 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase susceptibility ISO DNA:SNPs,haplotypes:multiple RGD PMID:20458436 RGD:401794454 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
JBrowse link
G Myrf myelin regulatory factor ISO DNA:SNP:exon:rs174535(human) RGD PMID:36193932 RGD:213230151 NCBI chr 1:206,854,175...206,886,276
Ensembl chr 1:206,854,175...206,886,157
JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 IEP protein:increased expression:brain, neuron, astrocyte: RGD PMID:17523870 RGD:401854233 NCBI chr16:19,526,633...19,533,567
Ensembl chr16:19,526,565...19,535,726
Ensembl chr 7:19,526,565...19,535,726
JBrowse link
G Nos3 nitric oxide synthase 3 ISO ClinVar Annotator: match by term: Ischemic stroke ClinVar PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 More... NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Notch3 notch receptor 3 ISO ClinVar Annotator: match by term: Ischemic stroke ClinVar PMID:9388399 PMID:10371548 PMID:10802804 PMID:10854111 PMID:11102981 More... NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025
JBrowse link
G Npy neuropeptide Y IEP
ISO
protein:increased expression:cerebral cortex
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:11821007 PMID:17123484 RGD:10448931 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 susceptibility ISO DNA:SNPs, haplotype:promoter:c.-115G>A, c.-840C>A (rs12221497, rs61896015) (human) RGD PMID:21903943 RGD:401842365 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO DNA:SNPs:peripheral blood, leukocyte, 3' utr RGD PMID:33209049 RGD:408418730 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Park7 Parkinsonism associated deglycase treatment ISO RGD PMID:18003894 PMID:18003894 RGD:13462069, RGD:13462069 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 ISO associated with Metabolic Syndrome; DNA:duplication:5' utr:-108 3G>4G (human) RGD PMID:18506375 RGD:2311309 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
JBrowse link
G Phactr1 phosphatase and actin regulator 1 ISO DNA:SNP:intron: (rs12526453) (human) RGD PMID:23042660 RGD:401900685 NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831
JBrowse link
G Pla2g7 phospholipase A2 group VII ISO RGD PMID:18201705 RGD:6482775 NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476
JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:1579960 PMID:1899364 PMID:9183334 PMID:16148626 PMID:18195371 More... NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plau plasminogen activator, urokinase ISO CTD Direct Evidence: therapeutic CTD PMID:12133459 PMID:16773802 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO RGD PMID:20138161 RGD:6483804 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Pon1 paraoxonase 1 susceptibility ISO DNA:missense mutation:cds:p.Q192R (human) RGD PMID:10729395 RGD:1580196 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pon2 paraoxonase 2 susceptibility ISO DNA:SNPs,haplotypes: (rs11545941, rs6954345) (human) RGD PMID:20458436 RGD:401794454 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
JBrowse link
G Prkch protein kinase C, eta susceptibility ISO ClinVar Annotator: match by term: Cerebral infarction, susceptibility to | ClinVar Annotator: match by term: Ischemic stroke ClinVar
OMIM
PMID:12958323 PMID:17206144 PMID:25741868 NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa ISO CTD Direct Evidence: marker/mechanism CTD PMID:33761690 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G Pros1 protein S ISO DNA:missense mutation:exon:p.R355C (1063C>T) (human) RGD PMID:21172841 RGD:11250416 NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286
JBrowse link
G Ptgis prostaglandin I2 synthase exacerbates
treatment
ISO
IMP
DNA:SNP, haplotype:3' utr: (rs5602) (human)
DNA:SNPs:exon, 3' utr: (rs5629, rs5602) (human)
DNA:repeat:promoter:g.-6(CCGCCAGCC)3-7 (human)
RGD PMID:28478978 PMID:28108096 PMID:11130769 PMID:11997284 RGD:401901149, RGD:401959400, RGD:401901269, RGD:401901194 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
JBrowse link
G Rbp4 retinol binding protein 4 exacerbates
severity
ISO protein:increased expression:blood plasma (human)
protein:increased expression:blood serum (human)
associated with diabetes mellitus; protein:increased expression:blood serum (human)
RGD PMID:19846170 PMID:30030781 PMID:30038059 RGD:329845582, RGD:329853305, RGD:329845588 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399
JBrowse link
G RT1-CE16 RT1 class I, locus CE16 susceptibility ISO DNA:polymorphism::HLA-A31:01 (human) RGD PMID:24767290 RGD:401827096 NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 susceptibility ISO DNA:polymorphism,haplotype::HLA-B37:01 (human) RGD PMID:24767290 RGD:401827096 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G Serpine1 serpin family E member 1 treatment IDA RGD PMID:25702149 RGD:11075081 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Serping1 serpin family G member 1 treatment ISO associated with Venous Thrombosis RGD PMID:10446335 RGD:8661653 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
JBrowse link
G Slc6a1 solute carrier family 6 member 1 IEP mRNA:increased expression:cerebral cortex, neuron RGD PMID:15349978 RGD:1643205 NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO mRNA:increased expression:blood (human) RGD PMID:35041140 RGD:155598600 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
JBrowse link
G Tbxas1 thromboxane A synthase 1 susceptibility ISO DNA:polymorphisms: : RGD PMID:19403042 RGD:11059536 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
JBrowse link
G Thbd thrombomodulin susceptibility ISO DNA:missense mutation:cds:p.A455V (human) RGD PMID:15574195 RGD:5685021 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:16173529 PMID:29111308 RGD:1580315, RGD:155260331 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B disease_progression ISO RGD PMID:19895657 RGD:7205492 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 ISO DNA:SNP: :rs2075650 (human) RGD PMID:26171154 RGD:13464126 NCBI chr 1:79,358,781...79,370,882
Ensembl chr 1:79,358,786...79,370,915
JBrowse link
G Tyms thymidylate synthetase susceptibility ISO DNA:SNPs,haplotypes: (rs502396,rs16430,rs8423) RGD PMID:20458436 RGD:401794454 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Vim vimentin IEP RGD PMID:18802758 RGD:6480442 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
lateral medullary syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fshb follicle stimulating hormone subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:17344003 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
middle cerebral artery infarction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 treatment IMP RGD PMID:23149556 PMID:24602692 RGD:12790979, RGD:12791996 NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
JBrowse link
G Ace angiotensin I converting enzyme treatment IMP RGD PMID:24471927 RGD:11039026 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin converting enzyme 2 IEP mRNA, protein:increased expression:brain RGD PMID:24090950 RGD:9685436 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acvr1 activin A receptor type 1 ISO RGD PMID:33345977 RGD:329845521 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241
JBrowse link
G Acvr2b activin A receptor type 2B ISO mRNA:increased expression:brain (mouse) RGD PMID:33763412 RGD:329849104 NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458
JBrowse link
G Adora1 adenosine A1 receptor ISO CTD Direct Evidence: therapeutic CTD PMID:23437309 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Ager advanced glycosylation end product-specific receptor IEP
ISO
associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:25446913 PMID:24211797 RGD:8696008 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Agt angiotensinogen IEP protein:increased expression:brain, serum RGD PMID:24090950 RGD:9685436 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 IEP protein:altered localization: : RGD PMID:15181376 RGD:10047403 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Ak1 adenylate kinase 1 IEP protein:decreased expression:cerebral cortex (rat) RGD PMID:16468349 RGD:5508760 NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
JBrowse link
G Alb albumin treatment ISO RGD PMID:22227456 RGD:11036100 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19309543 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 IEP protein:increased degradation:brain RGD PMID:19240038 RGD:13461853 NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 treatment IEP RGD PMID:24012531 RGD:13703113 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Apoe apolipoprotein E IDA RGD PMID:19623195 RGD:6903926 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G App amyloid beta precursor protein treatment IEP RGD PMID:28963051 RGD:13782054 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aqp4 aquaporin 4 treatment IEP
IMP
RGD PMID:20815926 PMID:33127515 RGD:8695955, RGD:155646130 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein IEP RGD PMID:22645329 RGD:10395314 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Atf3 activating transcription factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Bad BCL2-associated agonist of cell death treatment IDA RGD PMID:22200499 PMID:21891976 RGD:10053665, RGD:10053704 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:23143152 RGD:10054501 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcan brevican IEP RGD PMID:15869933 RGD:9590118 NCBI chr 2:173,454,479...173,467,717
Ensembl chr 2:173,454,482...173,467,460
JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP RGD PMID:23143152 RGD:10054501 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bdnf brain-derived neurotrophic factor treatment IEP RGD PMID:20417695 PMID:28202057 PMID:35218623 RGD:4891138, RGD:405878057, RGD:401960864 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 treatment IMP RGD PMID:22108007 RGD:11561900 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bnip3 BCL2 interacting protein 3 IEP protein:increased expression:brain RGD PMID:17379825 RGD:9685412 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Bnip3l BCL2 interacting protein 3 like IEP RGD PMID:15902200 PMID:21029239 RGD:2314138, RGD:9068917 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G C1qtnf6 C1q and TNF related 6 ameliorates IEP RGD PMID:35322553 RGD:242905190 NCBI chr 7:110,077,867...110,084,584
Ensembl chr 7:110,077,878...110,084,412
JBrowse link
G C3 complement C3 IEP
ISO
protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:23199288 PMID:22103620 RGD:7175514 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Calca calcitonin-related polypeptide alpha treatment IEP RGD PMID:30531687 RGD:329849008 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha IEP RGD PMID:14688616 RGD:1358416 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Casp3 caspase 3 treatment IDA
IEP
RGD PMID:21891976 PMID:26868427 PMID:23143152 RGD:10053704, RGD:13782346, RGD:10054501 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 IEP RGD PMID:26868427 RGD:13782346 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp9 caspase 9 treatment IEP RGD PMID:26868427 RGD:13782346 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:12374626 PMID:23043544 PMID:25257527 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Cd36 CD36 molecule treatment ISO RGD PMID:25216018 RGD:11041113 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cd86 CD86 molecule IEP protein:increased expression:brain subventricular zone, microglial cell (rat) RGD PMID:19053043 RGD:2313025 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cdk5 cyclin-dependent kinase 5 ISO RGD PMID:24920629 RGD:13782375 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
JBrowse link
G Cldn5 claudin 5 treatment IEP RGD PMID:24842554 RGD:13204729 NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment IDA RGD PMID:35218623 RGD:401960864 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crh corticotropin releasing hormone IEP protein:decreased expression:median eminence of hypothalamus (rat) RGD PMID:21741032 RGD:5490538 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crp C-reactive protein ISO RGD PMID:15545914 RGD:9585995 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Crtc1 CREB regulated transcription coactivator 1 treatment IEP RGD PMID:20417695 RGD:4891138 NCBI chr16:18,988,197...19,046,914
Ensembl chr16:18,988,250...19,043,381
JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO
IEP
mRNA, protein:increased expression:brain: RGD PMID:19298757 PMID:15530654 RGD:11039420, RGD:11039425 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO RGD PMID:10825390 RGD:632989 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 IEP mRNA:increased expression:cerebral cortex RGD PMID:10825390 RGD:632989 NCBI chr  X:66,844,318...66,846,969
Ensembl chr  X:66,844,318...66,846,969
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 IEP RGD PMID:23002367 RGD:14700877 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Dicer1 dicer 1 ribonuclease III IEP mRNA:decreased expression:brain: RGD PMID:26294080 RGD:11553310 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965
JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO RGD PMID:11726790 RGD:9588643 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha IMP RGD PMID:23516428 RGD:9589049 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
JBrowse link
G Dynll1 dynein light chain LC8-type 1 IEP RGD PMID:9522364 RGD:13208524 NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741
JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17197033 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Egr1 early growth response 1 IEP RGD PMID:22645329 RGD:10395314 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Egr2 early growth response 2 IEP RGD PMID:22645329 RGD:10395314 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
JBrowse link
G Egr4 early growth response 4 IEP RGD PMID:22645329 RGD:10395314 NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha treatment IDA
IMP
RGD PMID:23669639 PMID:19763736 RGD:10395346, RGD:10755569 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Elane elastase, neutrophil expressed treatment IMP RGD PMID:10700596 RGD:10450546 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
JBrowse link
G Eng endoglin ISO RGD PMID:24876084 RGD:11041171 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Epcam epithelial cell adhesion molecule IEP RGD PMID:15950761 RGD:11038820 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G Ephb2 Eph receptor B2 treatment IEP
ISO
mRNA,protein:increased expression: cortex, cerebral cortex subventricular zone RGD PMID:16321245 PMID:16321245 RGD:1642069, RGD:1642069 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059
JBrowse link
G Epn1 Epsin 1 IEP protein:increased degradation:brain RGD PMID:19240038 RGD:13461853 NCBI chr 1:68,742,491...68,760,570
Ensembl chr 1:68,742,789...68,758,874
JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:20833153 PMID:20547143 RGD:10400898, RGD:10401066 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor IEP RGD PMID:9974119 RGD:10401103 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
JBrowse link
G F11 coagulation factor XI ISO RGD PMID:16533887 RGD:11041786 NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437
JBrowse link
G F12 coagulation factor XII treatment ISO RGD PMID:16533887 PMID:16533887 RGD:11041786, RGD:11041786 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
JBrowse link
G F2 coagulation factor II, thrombin ISO CTD Direct Evidence: marker/mechanism CTD PMID:29651748 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Fadd Fas associated via death domain treatment ISO
IEP
RGD PMID:18950622 PMID:23378241 RGD:11341807, RGD:11344885 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fgf2 fibroblast growth factor 2 treatment IEP RGD PMID:30531687 RGD:329849008 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgf21 fibroblast growth factor 21 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
JBrowse link
G Gap43 growth associated protein 43 treatment IEP RGD PMID:30531687 RGD:329849008 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase IDA RGD PMID:25882840 RGD:13792686 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gch1 GTP cyclohydrolase 1 treatment IEP RGD PMID:24956890 RGD:401717568 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
JBrowse link
G Gdnf glial cell derived neurotrophic factor treatment IMP
IEP
IDA
RGD PMID:29497380 PMID:28202057 PMID:20468049 PMID:21347705 RGD:40925919, RGD:405878057, RGD:405866363, RGD:405866359 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide treatment IDA RGD PMID:19352052 RGD:9850083 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
JBrowse link
G Ghsr growth hormone secretagogue receptor IMP RGD PMID:19352052 RGD:9850083 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865
JBrowse link
G Glul glutamate-ammonia ligase treatment IEP protein:increased expression:eye
protein:increased expression:cerebrum, astrocyte
RGD PMID:24518488 PMID:23595285 PMID:26024074 PMID:26093193 RGD:401794420, RGD:401794586, RGD:401794592, RGD:401794587 NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 treatment IEP RGD PMID:26674869 RGD:11068571 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grn granulin precursor treatment ISO RGD PMID:23972823 RGD:10401661 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
JBrowse link
G Grpel1 GrpE-like 1, mitochondrial IEP mRNA:increased expression:cerebral cortex RGD PMID:12505684 RGD:632868 NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment IDA RGD PMID:28440874 RGD:13792734 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsn gelsolin ameliorates ISO RGD PMID:18234195 PMID:9927495 RGD:329333031, RGD:329333033 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G H19 H19 imprinted maternally expressed transcript ameliorates IEP
ISO
IMP
RNA:increased expression:brain (rat)
RNA:increased expression:brain (mouse)
RGD PMID:28203482 PMID:28630232 PMID:35322553 PMID:31170091 PMID:32335212 RGD:155900760, RGD:242905192, RGD:242905190, RGD:242905188, RGD:156451661 NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
JBrowse link
G Hamp hepcidin antimicrobial peptide IEP mRNA, protein:increased expression:cerebral cortex, hippocampus, corpus striatum RGD PMID:21957487 RGD:11041635 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Has2 hyaluronan synthase 2 IEP mRNA:increased expression:brain RGD PMID:11283406 RGD:9588631 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
JBrowse link
G Hdac2 histone deacetylase 2 exacerbates ISO RGD PMID:32239566 RGD:155883173 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hdac4 histone deacetylase 4 treatment IEP mRNA,protein:decreased expression:brain: RGD PMID:23480850 RGD:9681449 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
JBrowse link
G Hdac5 histone deacetylase 5 treatment IEP mRNA,protein:decreased expression:brain: RGD PMID:23480850 RGD:9681449 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Hdac9 histone deacetylase 9 IEP mRNA:increased expression:brain: RGD PMID:23480850 RGD:9681449 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha treatment IDA RGD PMID:21029239 RGD:9068917 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmgb1 high mobility group box 1 treatment IEP RGD PMID:23480850 RGD:9681449 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565
JBrowse link
G Hmox1 heme oxygenase 1 treatment IEP
IDA
ISO
RGD PMID:24252362 PMID:23870531 PMID:20888632 RGD:10755587, RGD:10755755, RGD:10755588 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hp haptoglobin IEP RGD PMID:22103620 RGD:7175514 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 IMP
ISO
rat gene in mouse model RGD PMID:17473852 PMID:21709150 RGD:5688754, RGD:6218961 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Htra2 HtrA serine peptidase 2 IEP
ISO
protein:increased expression:brain, cytosol (rat)
protein:increased expression:brain, cytosol (mouse)
RGD PMID:16978742 PMID:15306124 RGD:2314385, RGD:5688372 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
JBrowse link
G Hvcn1 hydrogen voltage-gated channel 1 IMP RGD PMID:31250553 RGD:14985213 NCBI chr12:34,341,673...34,370,010
Ensembl chr12:34,335,190...34,370,141
JBrowse link
G Hvcn1em2Mcwi hydrogen voltage-gated channel 1; zinc finger nuclease induced mutant 2, Medical College of Wisconsin IMP RGD PMID:31250553 RGD:14985213
G Icam1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Igf1 insulin-like growth factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta treatment ISO RGD PMID:16286924 RGD:10045955 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il10 interleukin 10 ameliorates ISO RGD PMID:28630232 RGD:242905192 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il11 interleukin 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
JBrowse link
G Il13 interleukin 13 IEP protein:increased expression:cerebral cortex RGD PMID:23028794 RGD:7204480 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1b interleukin 1 beta ameliorates
treatment
IEP
ISO
protein:increased expression:cerebral cortex (rat)
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:25257527 PMID:23028794 PMID:35322553 PMID:29498696 PMID:24916922 RGD:7204480, RGD:242905190, RGD:13792833, RGD:10450594 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO human gene in a rat model RGD PMID:7790404 RGD:8551708 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il22 interleukin 22 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chr 7:53,801,206...53,805,673
Ensembl chr 7:53,801,206...53,806,186
JBrowse link
G Il4 interleukin 4 IEP protein:increased expression:cerebral cortex RGD PMID:23028794 RGD:7204480 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 IEP RGD PMID:23028794 RGD:7204480 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 treatment ISO
IEP
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:12374626 PMID:21940958 PMID:25257527 PMID:29498696 RGD:13792833 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21940958 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Il6st interleukin 6 cytokine family signal transducer ISO CTD Direct Evidence: marker/mechanism CTD PMID:21940958 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
JBrowse link
G Il7r interleukin 7 receptor IEP protein:increased expression:brain: RGD PMID:30676545 RGD:151347693 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha ISO RGD PMID:29967576 RGD:27226878 NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330
JBrowse link
G Inhba inhibin subunit beta A ISO RGD PMID:33345977 RGD:329845521 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Irf4 interferon regulatory factor 4 IEP RGD PMID:25652434 RGD:11530061 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 ameliorates ISO
IMP
RGD PMID:26661208 PMID:25477223 PMID:21750563 RGD:329955572, RGD:401700383, RGD:329955444 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
JBrowse link
G Lig3 DNA ligase 3 IEP associated with transient cerebral ischemia;protein:increased expression:brain RGD PMID:17412650 RGD:2302580 NCBI chr10:67,717,808...67,741,141
Ensembl chr10:67,717,812...67,798,414
JBrowse link
G Mag myelin-associated glycoprotein treatment IMP RGD PMID:15678116 RGD:9685232 NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment IDA RGD PMID:27152455 PMID:35218623 RGD:13800881, RGD:401960864 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment IDA RGD PMID:27152455 PMID:35218623 RGD:13800881, RGD:401960864 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapt microtubule-associated protein tau treatment IEP
IDA
ISO
RGD PMID:28886009 PMID:25903928 PMID:28886009 RGD:13800886, RGD:13800913, RGD:13800886 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mir107 microRNA 107 IEP RNA:increased expression:brain RGD PMID:26294080 RGD:11553310 NCBI chr 1:232,337,767...232,337,853
Ensembl chr 1:232,337,767...232,337,853
JBrowse link
G Mir132 microRNA 132 treatment ISO mRNA:decreased expression:brain (mouse) RGD PMID:33763412 PMID:33763412 RGD:329849104, RGD:329849104 NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796
JBrowse link
G Mir140 microRNA 140 ameliorates ISO
IEP
miRNA:decreased expression:cerebral cortex (rat) RGD PMID:33246036 PMID:27035554 RGD:329337375, RGD:329337377 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675
JBrowse link
G Mir19a microRNA 19a ISO RNA:decreased expression:brain (mouse) RGD PMID:32335212 RGD:156451661 NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993
JBrowse link
G Mir210 microRNA 210 treatment IEP RGD PMID:34337881 RGD:155269103 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454
JBrowse link
G Mir29b1 microRNA 29b-1 exacerbates IMP RGD PMID:35322553 RGD:242905190 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067
JBrowse link
G Mir494 microRNA 494 ameliorates ISO RGD PMID:32239566 PMID:31465536 RGD:155883173, RGD:156430320 NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793
JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO
IEP
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:19309543 PMID:24842554 RGD:13204729 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mt3 metallothionein 3 IEP protein:decreased expression:brain RGD PMID:8869568 RGD:9685807 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment IEP
IDA
RGD PMID:24583056 PMID:21185267 PMID:23777415 RGD:10040971, RGD:10041016, RGD:10040974 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nae1 NEDD8 activating enzyme E1 subunit 1 IEP RGD PMID:21386696 RGD:13801046 NCBI chr19:446,015...472,145
Ensembl chr19:446,000...472,371
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase treatment IMP RGD PMID:28495827 RGD:13781880 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Ncam1 neural cell adhesion molecule 1 treatment ISO
IMP
RGD PMID:32962079 PMID:29497380 RGD:40924633, RGD:40925919 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Nefh neurofilament heavy chain ISO RGD PMID:29967576 RGD:27226878 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nefl neurofilament light chain ISO protein:increased expression:brain RGD PMID:29967576 RGD:27226878 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Nefm neurofilament medium chain ISO protein:altered expression:brain RGD PMID:29967576 RGD:27226878 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 treatment IDA RGD PMID:23880501 PMID:24466583 RGD:10412696, RGD:10412714 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha treatment IEP RGD PMID:21122797 RGD:10413868 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngf nerve growth factor treatment ISO
IMP
CTD Direct Evidence: therapeutic CTD
RGD
PMID:10408807 PMID:29409115 RGD:402463967 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ngfr nerve growth factor receptor treatment IDA RGD PMID:22678884 RGD:10413900 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 treatment IEP RGD PMID:24842554 RGD:13204729 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Nos2 nitric oxide synthase 2 IEP
ISO
protein:increased expression:brain (rat)
mRNA:increased expression:brain (mouse)
RGD PMID:21959178 PMID:22020035 RGD:5508751, RGD:5509037 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nox1 NADPH oxidase 1 treatment IEP RGD PMID:30816157 RGD:329955567 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP protein:increased expression:brain RGD PMID:21120604 PMID:25069640 RGD:5133239, RGD:11035212 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nrg1 neuregulin 1 treatment
ameliorates
ISO RGD PMID:20691195 PMID:30206770 RGD:10449015, RGD:405650589 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase treatment IEP associated with Hypertension RGD PMID:17920569 RGD:8657395 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Park7 Parkinsonism associated deglycase treatment ISO RGD PMID:17882163 RGD:13463450 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 treatment ISO
IDA
IEP
RGD PMID:21311064 PMID:25882840 PMID:23143152 PMID:23801245 RGD:5683909, RGD:13792686, RGD:10054501, RGD:11073732 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pawr pro-apoptotic WT1 regulator treatment ISO
IEP
protein:increased expression:brain: RGD PMID:16403464 PMID:19352052 PMID:11323519 RGD:9835380, RGD:9850083, RGD:9835381 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha treatment IDA RGD PMID:16917016 RGD:11084934 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta treatment IDA RGD PMID:16917016 RGD:11084934 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Plat plasminogen activator, tissue type IEP
ISO
CTD Direct Evidence: therapeutic CTD
RGD
PMID:12297567 PMID:17690543 PMID:18453163 PMID:20547619 PMID:29651748 More... RGD:1580876 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plau plasminogen activator, urokinase ISO CTD Direct Evidence: therapeutic CTD PMID:11677890 PMID:15181847 PMID:17702958 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Pld1 phospholipase D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
JBrowse link
G Polb DNA polymerase beta IEP associated with transient cerebral ischemia;protein:increased expression:brain RGD PMID:17412650 RGD:2302580 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812
JBrowse link
G Prkcg protein kinase C, gamma ISO RGD PMID:14688616 RGD:1358416 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:24159062 RGD:11100027 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 IEP mRNA:increased expression:cerebral cortex RGD PMID:15869933 RGD:9590118 NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218
JBrowse link
G Rbfox3 RNA binding fox-1 homolog 3 treatment IEP RGD PMID:30531687 RGD:329849008 NCBI chr10:103,720,355...104,157,277
Ensembl chr10:103,720,636...104,156,935
JBrowse link
G Reln reelin severity ISO RGD PMID:16438965 RGD:13207538 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a treatment IEP
IMP
RGD PMID:21840379 PMID:23275173 RGD:9850121, RGD:9850122 NCBI chr 1:127,128,934...127,172,918
Ensembl chr 1:127,128,934...127,172,918
JBrowse link
G Rpl28 ribosomal protein L28 IEP RGD PMID:16805800 RGD:6480229 NCBI chr 1:69,052,148...69,054,735
Ensembl chr 1:69,053,203...69,055,032
JBrowse link
G Runx1 RUNX family transcription factor 1 IAGP mRNA:increased expression:brain RGD PMID:24672479 RGD:11251714 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
JBrowse link
G S100a5 S100 calcium binding protein A5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chr 2:176,095,332...176,099,546
Ensembl chr 2:176,097,539...176,099,546
JBrowse link
G S100b S100 calcium binding protein B IEP protein:increased expression:cerebrum, astrocyte RGD PMID:23595285 RGD:401794586 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G Serpine1 serpin family E member 1 IEP RGD PMID:14512838 RGD:1580876 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Serpinf1 serpin family F member 1 treatment IDA RGD PMID:22714093 RGD:8655545 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
JBrowse link
G Serpinh1 serpin family H member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801
JBrowse link
G Shh sonic hedgehog signaling molecule treatment ISO RGD PMID:22324418 RGD:12879461 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Sirt1 sirtuin 1 treatment IMP
ISO
RGD PMID:23600725 PMID:23600725 RGD:9585664, RGD:9585664 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc12a2 solute carrier family 12 member 2 treatment IMP
ISO
protein:increased expression:brain: RGD PMID:12535773 PMID:27798271 RGD:1580583, RGD:14398833 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
JBrowse link
G Slc1a2 solute carrier family 1 member 2 treatment IEP RGD PMID:20423712 RGD:401794585 NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
JBrowse link
G Slc2a1 solute carrier family 2 member 1 treatment IEP RGD PMID:9419067 RGD:12879855 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc9a1 solute carrier family 9 member A1 treatment IMP RGD PMID:31250553 RGD:14985213 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor treatment IEP RGD PMID:14500739 RGD:9999390 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Smo smoothened, frizzled class receptor treatment IMP RGD PMID:23696546 PMID:23499832 RGD:12832759, RGD:12879404 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829
JBrowse link
G Smox spermine oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:30576531 NCBI chr 3:118,731,814...118,767,242
Ensembl chr 3:118,731,900...118,765,710
Ensembl chr  X:118,731,900...118,765,710
JBrowse link
G Snap91 synaptosome associated protein 91 IEP protein:increased degradation:brain RGD PMID:19240038 RGD:13461853 NCBI chr 8:87,738,056...87,852,690
Ensembl chr 8:87,738,824...87,852,367
JBrowse link
G Sod1 superoxide dismutase 1 treatment IDA
IEP
mRNA, protein:increased expression:cerebral cortex (rat) RGD PMID:22001340 PMID:22133807 RGD:8657021, RGD:8657023 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21940958 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sphk2 sphingosine kinase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:23043544 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21940958 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ameliorates IEP
ISO
RGD PMID:31409163 PMID:28630232 RGD:14995477, RGD:242905192 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Th tyrosine hydroxylase IEP protein:decreased expression:substantia nigra pars compacta, neuron (rat) RGD PMID:21366664 RGD:5128609 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor treatment
ameliorates
IEP
ISO
IMP
RGD PMID:24916922 PMID:28630232 PMID:35322553 PMID:15647744 PMID:29498696 RGD:10450594, RGD:242905192, RGD:242905190, RGD:13825261, RGD:13792833 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IMP RGD PMID:15647744 RGD:13825261 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 ameliorates IDA RGD PMID:32736673 RGD:127284860 NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
JBrowse link
G Upp1 uridine phosphorylase 1 IEP mRNA, protein:increased expression:brain (rat) RGD PMID:18457515 RGD:2317094 NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462
JBrowse link
G Vegfa vascular endothelial growth factor A treatment IMP
IEP
mRNA,protein:increased expression:cerebral cortex (rat) RGD PMID:29497380 PMID:30531687 PMID:27035554 RGD:40925919, RGD:329849008, RGD:329337377 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xdh xanthine dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 IEP associated with transient cerebral ischemia;protein:increased expression:brain RGD PMID:17412650 RGD:2302580 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
JBrowse link
Multi-Infarct Dementia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO protein:decreased expression:cerebrospinal fluid: RGD PMID:1677459 RGD:10054257 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:18938189 RGD:10054050 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP RGD PMID:18938189 RGD:10054050 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase treatment IEP RGD PMID:21279683 RGD:10449132 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Il2 interleukin 2 severity ISO protein:increased secretion:mononuclear cell: RGD PMID:8586980 RGD:10047081 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19100
    Pathological Conditions, Signs and Symptoms 13604
      Pathologic Processes 8260
        ischemia 1503
          brain ischemia 644
            brain infarction 320
              brain stem infarction + 1
              cerebral infarction + 276
Path 2
Term Annotations click to browse term
  disease 19100
    disease of anatomical entity 18440
      nervous system disease 14334
        central nervous system disease 12604
          brain disease 11833
            cerebrovascular disease 1000
              brain ischemia 644
                brain infarction 320
                  brain stem infarction + 1
                  cerebral infarction + 276
paths to the root