ischemia - Ontology Report - Rat Genome Database

RGD

PMID:10375453

RGD:1598516

NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835

Acta2

actin alpha 2, smooth muscle

CTD Direct Evidence: marker/mechanism

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

Adnp

activity-dependent neuroprotector homeobox

RGD

PMID:18414890

RGD:2312783

NCBI chr 3:156,886,921...156,921,500
Ensembl chr 3:156,891,381...156,917,312

Adora1

adenosine A1 receptor

CTD Direct Evidence: marker/mechanism

PMID:18950269

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

Adora3

adenosine A3 receptor

CTD Direct Evidence: marker/mechanism

PMID:7774659

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357

Akt2

AKT serine/threonine kinase 2

PMID:14633620 PMID:14633620

RGD

PMID:19084003

RGD:2313316

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

angiopoietin 2

RGD

NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804

annexin A1

RGD

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

Arid1b

AT-rich interaction domain 1B

IDA
IEP

mRNA,protein:increased expression:renal medulla, cortex of kidney

RGD

RGD:1302474, RGD:1302474

NCBI chr 1:45,567,991...45,923,644
Ensembl chr 1:45,563,623...45,923,493

autophagy related 5

RGD

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

Avp

arginine vasopressin

CTD Direct Evidence: marker/mechanism

PMID:2139164 PMID:10440088

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

Bax

BCL2 associated X, apoptosis regulator

CTD Direct Evidence: marker/mechanism

PMID:15172883

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

beclin 1

RGD

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

Calca

calcitonin-related polypeptide alpha

RGD

PMID:21181115

RGD:5684019

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

C-C motif chemokine ligand 2

RGD

PMID:15308783

RGD:1581163

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

Cd68

Cd68 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

Ckm

creatine kinase, M-type

CTD Direct Evidence: marker/mechanism

PMID:21912612

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

ceruloplasmin

CTD Direct Evidence: marker/mechanism

PMID:15668637 PMID:18091701

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

Crhr2

corticotropin releasing hormone receptor 2

RGD

PMID:19429103

RGD:5130953

NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904

Cx3cl1

C-X3-C motif chemokine ligand 1

RGD

PMID:18006432

RGD:4892022

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

Cxcl10

C-X-C motif chemokine ligand 10

mRNA:increased expression:lung

RGD

PMID:16709871

RGD:5135441

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

Cxcl12

C-X-C motif chemokine ligand 12

CTD Direct Evidence: marker/mechanism

PMID:18227068

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

Cxcr3

C-X-C motif chemokine receptor 3

CTD Direct Evidence: marker/mechanism

PMID:12517959

NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969

Cycs

cytochrome c, somatic

CTD Direct Evidence: marker/mechanism

PMID:15172883

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

Dll4

delta like canonical Notch ligand 4

ameliorates

PMID:25834117 PMID:22252294

mRNA,protein:increased expression:skin,endothelial cells

RGD

RGD:155663350, RGD:155663358

NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931

Egr1

early growth response 1

CTD Direct Evidence: marker/mechanism

PMID:12468449

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

Flt1

Fms related receptor tyrosine kinase 1

protein:increased expression:skeletal muscle

RGD

PMID:17823371

RGD:2313719

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

Gja1

gap junction protein, alpha 1

protein:increased expression:urothelium:

RGD

PMID:24728265

RGD:11568671

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

Gjb2

gap junction protein, beta 2

in urinary bladder; protein:increased expression:urothelium:

RGD

PMID:24728265

RGD:11568671

NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177

Hmox1

heme oxygenase 1

CTD Direct Evidence: therapeutic

PMID:15036356 PMID:19667931

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

Htr1b

5-hydroxytryptamine receptor 1B

mRNA:increased expression:skeletal muscle

RGD

PMID:12393100

RGD:1626445

NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549

interleukin 18

RGD

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

interleukin 6

CTD Direct Evidence: marker/mechanism

PMID:18091701

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Itgav

integrin subunit alpha V

RGD

PMID:15956135

RGD:1582457

NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639

Lipc

lipase C, hepatic type

protein:decreased expression:liver (rat)

RGD

PMID:1918876

RGD:2308796

NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464

Lonp1

lon peptidase 1, mitochondrial

RGD

PMID:12082077

RGD:633879

NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771

Map1lc3a

microtubule-associated protein 1 light chain 3 alpha

RGD

PMID:25435100

RGD:11561945

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

Mapk9

mitogen-activated protein kinase 9

CTD Direct Evidence: marker/mechanism

PMID:19667931

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

Mmp14

matrix metallopeptidase 14

RGD

PMID:16077081

RGD:1582563

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

Mmp2

matrix metallopeptidase 2

RGD

PMID:12842442

RGD:1582562

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

matrix metallopeptidase 9

RGD

PMID:15047130

RGD:1582640

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

Mthfr

methylenetetrahydrofolate reductase

susceptibility

associated with Retinal Vein Occlusion;DNA:SNP:cds:677C>T(human)

RGD

PMID:17719079

RGD:7387251

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

Muc13

mucin 13, cell surface associated

protein:increased degradation:jejunum

RGD

PMID:22768227

RGD:7349363

NCBI chr11:66,957,208...66,980,264
Ensembl chr11:66,960,595...66,984,727

Muc2

mucin 2, oligomeric mucus/gel-forming

protein:decreased expression:jejunum

RGD

PMID:22768227

RGD:7349363

NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756

nitric oxide synthase 3

CTD Direct Evidence: therapeutic

PMID:15036356

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

Oxt

oxytocin/neurophysin I prepropeptide

CTD Direct Evidence: marker/mechanism

PMID:10440088

NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490

Pcna

proliferating cell nuclear antigen

CTD Direct Evidence: marker/mechanism

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

plasminogen activator, urokinase

PMID:8662173 PMID:15557913 PMID:17653104

CTD Direct Evidence: therapeutic

CTD
RGD

RGD:6484145

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

Pparg

peroxisome proliferator-activated receptor gamma

CTD Direct Evidence: therapeutic

PMID:12468449 PMID:24433871

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

Prkca

protein kinase C, alpha

RGD

PMID:17700073

RGD:2292478

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

Ptges

prostaglandin E synthase

RGD

PMID:12431630

RGD:2300116

NCBI chr 3:14,177,892...14,189,236

Ptk2

protein tyrosine kinase 2

protein:decreased tyrosine phosphorylation:kidney

RGD

PMID:17620366

RGD:2292577

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

Raf1

Raf-1 proto-oncogene, serine/threonine kinase

RGD

PMID:16172266

RGD:1580696

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

Ren

renin

CTD Direct Evidence: marker/mechanism

PMID:3915608

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

S100a4

S100 calcium-binding protein A4

CTD Direct Evidence: marker/mechanism

NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254

selectin P

RGD

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

Serpinh1

serpin family H member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801

splicing factor 1

RGD

NCBI chr 1:203,670,016...203,683,432
Ensembl chr 1:203,670,018...203,684,330

Sod1

superoxide dismutase 1

CTD Direct Evidence: therapeutic

PMID:10698074

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

superoxide dismutase 2

CTD Direct Evidence: therapeutic

PMID:11328670 PMID:18227068

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

Sst

somatostatin

CTD Direct Evidence: therapeutic

PMID:18624922

NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173

thrombomodulin

RGD

NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193

Tnfrsf1a

TNF receptor superfamily member 1A

RGD

PMID:14970118

RGD:1624195

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

Tp53

tumor protein p53

PMID:15172883 PMID:18337831

associated with Wounds and Injuries;protein:increased expression:skin
CTD Direct Evidence: marker/mechanism

CTD
RGD

RGD:2290551

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

Xdh

xanthine dehydrogenase

CTD Direct Evidence: marker/mechanism

PMID:22688000

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

Acute Coronary Syndrome

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Actg1

actin, gamma 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232

advanced glycosylation end product-specific receptor

protein:increased expression:serum (human)

RGD

PMID:21663912

RGD:5508825

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

Alb

albumin

treatment

RGD

PMID:20716836

RGD:11036086

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

Arhgdib

Rho GDP dissociation inhibitor beta

CTD Direct Evidence: marker/mechanism

NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658

Capzb

capping actin protein of muscle Z-line subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409

Ccn1

cellular communication network factor 1

susceptibility

DNA:SNP,haplotypes:5'utr: (rs6576776) (human)

RGD

PMID:33906697

RGD:329845569

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

Cd40

CD40 molecule

DNA:SNP:5' utr:rs1883832 (human)

RGD

PMID:21091218

RGD:5490523

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

Cd40lg

CD40 ligand

treatment

PMID:20170788 PMID:31624788

associated with Anxiety Disorders;protein:increased expression:serum

RGD

RGD:5490548, RGD:21081509

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

Ckb

creatine kinase B

CTD Direct Evidence: marker/mechanism

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

Ckm

creatine kinase, M-type

CTD Direct Evidence: marker/mechanism

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

Crp

C-reactive protein

PMID:15966572 PMID:23305094 PMID:18973750 PMID:21794939

CTD Direct Evidence: marker/mechanism
protein:increased expression: :

CTD
RGD

RGD:6907401, RGD:9491837

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

Cyp2c6

cytochrome P450, family 2, subfamily C, polypeptide 6

treatment

DNA:SNPs::CYP2C19*2 (681G>A,rs4244285), CYP2C19*17 (-806C>T, rs12248560) (human)
ClinVar Annotator: match by term: Acute coronary syndrome

ClinVar
RGD

PMID:7969038 PMID:9093256 PMID:19444287 PMID:21270786 PMID:21716271 More...

RGD:401960861

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

Eno1

enolase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

F12

coagulation factor XII

ClinVar Annotator: match by term: FACTOR XII POLYMORPHISM

PMID:9490684 PMID:11843842 PMID:20303064 PMID:24033266 PMID:25741868

NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530

coagulation factor II, thrombin

RGD

PMID:21496882

RGD:5147784

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

Fasn

fatty acid synthase

CTD Direct Evidence: marker/mechanism

PMID:23305094

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

Fto

FTO, alpha-ketoglutarate dependent dioxygenase

susceptibility

DNA:SNP: :rs17817449 (human)

RGD

PMID:20362563

RGD:329813083

NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083

Gapdh

glyceraldehyde-3-phosphate dehydrogenase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

Gch1

GTP cyclohydrolase 1

DNa:SNP: :rs3783637 (human)

RGD

PMID:26232608

RGD:329961571

NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698

Gp6

glycoprotein VI

disease_progression

PMID:17340467 PMID:20071043

protein:increased expression:platelet (human)

RGD

RGD:401794408, RGD:401824680

NCBI chr 1:69,429,232...69,492,709
Ensembl chr 1:69,465,789...69,491,326

Gpx1

glutathione peroxidase 1

mRNA, protein:increased expression:blood, plasma

RGD

PMID:28298473

RGD:401827171

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

glutathione peroxidase 3

mRNA, protein:increased expression:blood, plasma

RGD

PMID:28298473

RGD:401827171

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

Gpx4

glutathione peroxidase 4

mRNA, protein:increased expression:blood, plasma

RGD

PMID:28298473

RGD:401827171

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

Gsn

gelsolin

CTD Direct Evidence: marker/mechanism

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

Gstp1

glutathione S-transferase pi 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

Hspa1a

heat shock protein family A (Hsp70) member 1A

DNA:SNP: :190G>C(human)

RGD

PMID:21849784

RGD:7257650

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

Hspa8

heat shock protein family A (Hsp70) member 8

CTD Direct Evidence: marker/mechanism

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

Hspd1

heat shock protein family D (Hsp60) member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

interleukin 6

treatment

PMID:23305094 PMID:32178736 PMID:32178736

CTD Direct Evidence: marker/mechanism
protein:increased expression:blood serum (human)

CTD
RGD

RGD:155230830, RGD:155230830

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Itgb3

integrin subunit beta 3

CTD Direct Evidence: marker/mechanism

PMID:15840736

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

Ldhb

lactate dehydrogenase B

CTD Direct Evidence: marker/mechanism

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

Mir126a

microRNA 126a

RNA:decreased expression:plasma

RGD

PMID:27900989

RGD:401850572

NCBI chr 3:9,415,063...9,415,180
Ensembl chr 3:9,415,063...9,415,180

Mir145

microRNA 145

disease_progression
treatment

PMID:32178736 PMID:32178736

RNA:decreased expression:blood serum (human)

RGD

RGD:155230830, RGD:155230830

NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727

matrix metallopeptidase 9

CTD Direct Evidence: marker/mechanism

PMID:20981132

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

Ogg1

8-oxoguanine DNA glycosylase

susceptibility

DNA:SNP,haplotype: :p.S326C (rs1052133) (human)

RGD

PMID:23368530

RGD:401827273

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

Pappa

pappalysin

CTD Direct Evidence: marker/mechanism

PMID:11586954

NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666

Pdia3

protein disulfide isomerase family A, member 3

CTD Direct Evidence: marker/mechanism

NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236

Pecam1

platelet and endothelial cell adhesion molecule 1

protein:increased expression:coronary artery, intima (human)

RGD

PMID:22336504

RGD:6767292

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

Phactr1

phosphatase and actin regulator 1

exacerbates

protein:increased expression:monocyte (human)

RGD

PMID:32857129

RGD:401900689

NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831

Pla2g7

phospholipase A2 group VII

disease_progression

RGD

PMID:22024276

RGD:6482773

NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476

Pon1

paraoxonase 1

CTD Direct Evidence: marker/mechanism

PMID:26241956

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

Psmb1

proteasome 20S subunit beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560

Rab7b

Rab7b, member RAS oncogene family

CTD Direct Evidence: marker/mechanism

NCBI chr13:43,121,168...43,147,581
Ensembl chr13:43,121,226...43,147,581

Rbp4

retinol binding protein 4

severity
onset

PMID:25437889 PMID:32449048

protein:increased expression:blood plasma (human)
protein:increased expression:blood serum (human)

RGD

RGD:329845573, RGD:329845576

NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399

S100b

S100 calcium binding protein B

protein:increased expression:serum

RGD

PMID:21663912

RGD:5508825

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

Serpinc1

serpin family C member 1

CTD Direct Evidence: therapeutic

PMID:7923645

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

Tlr4

toll-like receptor 4

CTD Direct Evidence: marker/mechanism

PMID:20981132

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

tumor necrosis factor

treatment

PMID:20981132 PMID:32178736 PMID:32178736

CTD Direct Evidence: marker/mechanism
protein:increased expression:blood serum (human)

CTD
RGD

RGD:155230830, RGD:155230830

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tnni3

troponin I3, cardiac type

CTD Direct Evidence: marker/mechanism

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

Tnnt2

troponin T2, cardiac type

CTD Direct Evidence: marker/mechanism

NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388

Tpm4

tropomyosin 4

CTD Direct Evidence: marker/mechanism

NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984

Tuba1c

tubulin, alpha 1C

CTD Direct Evidence: marker/mechanism

NCBI chr 7:130,192,050...130,199,655
Ensembl chr 7:130,192,016...130,199,647
Ensembl chr X:130,192,016...130,199,647

Tubb1

tubulin, beta 1 class VI

CTD Direct Evidence: marker/mechanism

NCBI chr 3:163,247,990...163,257,460
Ensembl chr 3:163,247,967...163,256,063

Vcl

vinculin

CTD Direct Evidence: marker/mechanism

NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606

Vim

vimentin

CTD Direct Evidence: marker/mechanism

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

acute myocardial infarction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Arhgap17

Rho GTPase activating protein 17

ameliorates

RGD

NCBI chr 1:177,807,579...177,897,027
Ensembl chr 1:177,807,583...177,896,854

Bax

BCL2 associated X, apoptosis regulator

ameliorates

RGD

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

complement C3

RGD

PMID:26476955

RGD:11552746

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

Cacng4

calcium voltage-gated channel auxiliary subunit gamma 4

mRNA:decreased expression:blood:

RGD

PMID:27746059

RGD:13524557

NCBI chr10:92,683,778...92,745,842
Ensembl chr10:92,683,761...92,746,126

Casp3

caspase 3

treatment

RGD

PMID:26550220

RGD:13782284

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Casp7

caspase 7

treatment

RGD

PMID:26550220

RGD:13782284

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

Ccn1

cellular communication network factor 1

ameliorates

RGD

PMID:30371213

RGD:329845516

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

Dram1

DNA-damage regulated autophagy modulator 1

ameliorates

PMID:30144448 PMID:30144448

mRNA,protein:decreased expression:heart

RGD

RGD:407571674, RGD:407571674

NCBI chr 7:22,742,794...22,776,888
Ensembl chr 7:22,742,849...22,776,765

Dsc2

desmocollin 2

ameliorates

RGD

NCBI chr18:11,450,392...11,482,476
Ensembl chr18:11,450,390...11,482,392

Fos

Fos proto-oncogene, AP-1 transcription factor subunit

treatment

RGD

PMID:23054911

RGD:405650598

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

Fto

FTO, alpha-ketoglutarate dependent dioxygenase

mRNA:increased expression:blood

RGD

PMID:35693610

RGD:329901852

NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083

Gata5

GATA binding protein 5

susceptibility

DNA:SNPs:promoter:rs80197101, rs77067995 (human)

RGD

PMID:33684162

RGD:155260335

NCBI chr 3:167,418,563...167,426,751
Ensembl chr 3:167,418,565...167,426,751

Gp6

glycoprotein VI

ameliorates
sexual_dimorphism

PMID:20227257 PMID:20227257

DNA:missense mutation:CDS:p.S219P (rs1613662) (human)
DNA:missense mutation:intron 1, intron 5: (rs1671207, rs11084382) (human)

RGD

RGD:401794138, RGD:401794138

NCBI chr 1:69,429,232...69,492,709
Ensembl chr 1:69,465,789...69,491,326

glutathione peroxidase 3

protein:increased expression:plasma

RGD

PMID:28374671

RGD:401827832

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

Gsk3b

glycogen synthase kinase 3 beta

treatment
ameliorates

PMID:26591365 PMID:32068187

RGD

RGD:13792778, RGD:267358468

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

H19

H19 imprinted maternally expressed transcript

ameliorates

RGD

PMID:31755219

RGD:213230161

NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134

Idh2

isocitrate dehydrogenase (NADP(+)) 2

ClinVar Annotator: match by term: Acute myocardial infarction

PMID:20946881 PMID:21250968 PMID:21596855 PMID:21997850 PMID:22160010 More...

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

Ifng

interferon gamma

ameliorates

RGD

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

Ikbkg

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

ameliorates

RGD

NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499

Il10

interleukin 10

ameliorates

RGD

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

Il17a

interleukin 17A

ameliorates

RGD

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

interleukin 1 beta

ameliorates

RGD

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Il1rl1

interleukin 1 receptor-like 1

RGD

PMID:24837094

RGD:40813741

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

interleukin 33

RGD

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

Il4

interleukin 4

ameliorates

RGD

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

interleukin 6

ameliorates

RGD

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Itgam

integrin subunit alpha M

treatment

RGD

PMID:21238619

RGD:329901664

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

Kif6

kinesin family member 6

DNA:SNP: :p.W719R (rs20455) (human)

RGD

PMID:20044086

RGD:243048455

NCBI chr 9:11,076,203...11,373,205
Ensembl chr 9:11,072,824...11,373,006

Mir126a

microRNA 126a

disease_progression

PMID:36523365 PMID:32595526

RGD

RGD:401851047, RGD:401851053

NCBI chr 3:9,415,063...9,415,180
Ensembl chr 3:9,415,063...9,415,180

Mir146a

microRNA 146a

miRNA:increased expression:peripheral blood mononuclear cell, plasma

RGD

NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610

Mir155

microRNA 155

miRNA:decreased expression:peripheral blood mononuclear cell, plasma

RGD

NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718

Mir17

microRNA 17

treatment

RGD

PMID:29536180

RGD:329403057

NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712

Mir21

microRNA 21

PMID:31866771 PMID:32595526

miRNA:increased expression:peripheral blood mononuclear cell, plasma
RNA:decreased expression:serum

RGD

RGD:21081515, RGD:401851053

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

microRNA 223

treatment

RGD

PMID:29689569

RGD:25823140

NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996

microRNA 320a

RGD

NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473

Mt-co2

mitochondrially encoded cytochrome c oxidase II

ameliorates

RGD

NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689

Ndufb5

NADH:ubiquinone oxidoreductase subunit B5

ameliorates

associated with obesity

RGD

PMID:35257523

RGD:401794445

NCBI chr 2:115,519,248...115,533,589
Ensembl chr 2:115,519,154...115,533,589

Pf4

platelet factor 4

treatment

RGD

PMID:29407168

RGD:329901925

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

Plcg1

phospholipase C, gamma 1

ameliorates

RGD

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

Ppbp

pro-platelet basic protein

treatment

RGD

PMID:29407168

RGD:329901925

NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130

Pten

phosphatase and tensin homolog

ameliorates

PMID:26973267 PMID:32595526 PMID:29990866

mRNA:decreased expression:heart left ventricle (rat)
RNA:increased expression:serum

RGD

RGD:11526378, RGD:401851053, RGD:155882565

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

Rhoa

ras homolog family member A

ameliorates

RGD

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

Rit2

Ras-like without CAAX 2

ameliorates

RGD

NCBI chr18:22,565,403...22,921,648
Ensembl chr18:22,565,404...22,921,648

Sdhb

succinate dehydrogenase complex iron sulfur subunit B

ameliorates

associated with obesity

RGD

PMID:35257523

RGD:401794445

NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293

Serping1

serpin family G member 1

PMID:26476955 PMID:26476955

mRNA:increased expression:heart

RGD

RGD:11552746, RGD:11552746

NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034

Tbx1

T-box transcription factor 1

treatment

RGD

PMID:27422448

RGD:155882497

NCBI chr11:82,409,275...82,419,058
Ensembl chr11:82,409,275...82,418,380

tumor necrosis factor

ameliorates

RGD

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Zeb1

zinc finger E-box binding homeobox 1

ameliorates

RGD

NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214

Angina Pectoris

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

adrenoceptor beta 1

RGD

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

adrenoceptor beta 2

RGD

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

Avp

arginine vasopressin

CTD Direct Evidence: marker/mechanism

PMID:11128043 PMID:11791009

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

carboxypeptidase B2

RGD

NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556

Mir146a

microRNA 146a

miRNA:increased expression:peripheral blood mononuclear cell, plasma

RGD

NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610

Mir155

microRNA 155

miRNA:decreased expression:peripheral blood mononuclear cell, plasma

RGD

NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718

Mir21

microRNA 21

miRNA:increased expression:peripheral blood mononuclear cell, plasma

RGD

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

plasminogen activator, urokinase

CTD Direct Evidence: therapeutic

PMID:1730212

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

Ppbp

pro-platelet basic protein

protein:increased expression:plasma

RGD

PMID:17045893

RGD:401794448

NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130

Spp1

secreted phosphoprotein 1

RGD

PMID:16421174

RGD:1581390

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

anterolateral myocardial infarction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Edn1

endothelin 1

protein:increased expression:aortic root, coronary sinus, plasma (human)

RGD

PMID:12581682

RGD:8661757

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

serpin family E member 1

disease_progression

PMID:12615902 PMID:12615902

protein:decreased expression, decreased activity:heart:

RGD

RGD:13208541, RGD:13208541

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

Brain Hypoxia-Ischemia

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Acvr2b

activin A receptor type 2B

severity

mRNA, protein:increased expression:umbilical cord blood (human)

RGD

PMID:27957679

RGD:329849106

NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458

Ada

adenosine deaminase

protein:increased activity:brain:

RGD

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

Adk

adenosine kinase

protein:decreased expression:brain:

RGD

NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510

Adnp

activity-dependent neuroprotector homeobox

RGD

PMID:16938277

RGD:2312775

NCBI chr 3:156,886,921...156,921,500
Ensembl chr 3:156,891,381...156,917,312

Adora1

adenosine A1 receptor

protein:decreased expression:brain:

RGD

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

Agtr2

angiotensin II receptor, type 2

RGD

PMID:22569153

RGD:6903872

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

Aif1

allograft inflammatory factor 1

protein:increased expression:right cerebral hemisphere (rat)

RGD

PMID:19447505

RGD:2313021

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

Aifm1

apoptosis inducing factor, mitochondria associated 1

PMID:12871572 PMID:28108258

protein:increased expression:nucleus:

RGD

RGD:10053564, RGD:13524865

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

Bax

BCL2 associated X, apoptosis regulator

treatment

PMID:21189961 PMID:24089674 PMID:29635023

RGD

RGD:10054502, RGD:155882465, RGD:13782292

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

brevican

RGD

NCBI chr 2:173,454,479...173,467,717
Ensembl chr 2:173,454,482...173,467,460

Bcl2

BCL2, apoptosis regulator

treatment

PMID:21189961 PMID:24089674 PMID:29635023

RGD

RGD:10054502, RGD:155882465, RGD:13782292

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

Bcl2-like 1

RGD

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

Becn1

beclin 1

PMID:22449108 PMID:25919564

protein:increased expression:cerebral cortex
protein:increased expression:brain

RGD

RGD:6483050, RGD:11558017

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

Bmal1

basic helix-loop-helix ARNT like 1

protein:increased expression:pineal gland

RGD

PMID:23336172

RGD:10043348

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

Bmp4

bone morphogenetic protein 4

mRNA,protein:decreased expression:brain:

RGD

PMID:23236544

RGD:8699519

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

caspase 1

RGD

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

Casp12

caspase 12

protein:increased activity:cerebral cortex, hippocampus

RGD

PMID:18603371

RGD:2311455

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

Casp3

caspase 3

treatment

IDA
IEP

protein:increased activity:cerebral cortex, hippocampus

RGD

PMID:18603371 PMID:24089674 PMID:23046993 PMID:29635023 PMID:27216999 More...

RGD:2311455, RGD:155882465, RGD:13782359, RGD:13782292, RGD:13782279, RGD:10054502

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Casp8

caspase 8

treatment

PMID:29635023 PMID:23046993

RGD

RGD:13782292, RGD:13782359

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

Casp9

caspase 9

treatment

PMID:23046993 PMID:24089674

RGD

RGD:13782359, RGD:155882465

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

calpastatin

RGD

NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659

Cat

catalase

treatment

RGD

PMID:21978706

RGD:9068474

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

C-C motif chemokine ligand 2

protein:increased expression:forebrain (rat)

RGD

PMID:9270493

RGD:8549543

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

Ccr2

C-C motif chemokine receptor 2

mRNA, protein:increased expression:brain

RGD

PMID:18095591

RGD:4144890

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

Ccr5

C-C motif chemokine receptor 5

mRNA:increased expression:cerebral hemisphere (rat)

RGD

PMID:16516309

RGD:4890442

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

Cdk5r1

cyclin-dependent kinase 5 regulatory subunit 1

treatment

RGD

PMID:25665755

RGD:13782373

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

Clock

clock circadian regulator

protein:increased expression:pineal gland

RGD

PMID:23336172

RGD:10043348

NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400

Cnp

2',3'-cyclic nucleotide 3' phosphodiesterase

RGD

PMID:19747899

RGD:6483337

NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720

C-reactive protein

RGD

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

citrate synthase

treatment

PMID:15132986 PMID:15569775

RGD

RGD:243048479, RGD:243048481

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

Csf1r

colony stimulating factor 1 receptor

exacerbates

IMP
IEP

protein:increased expression:right cerebral hemisphere, astrocyte, neuron (rat)

RGD

PMID:32522286 PMID:33101590

RGD:151665765, RGD:151665766

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

Cxcr3

C-X-C motif chemokine receptor 3

mRNA:increased expression:brain

RGD

PMID:17549754

RGD:2311381

NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969

Daxx

death-domain associated protein

RGD

PMID:21843499

RGD:9587791

NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843

Dnmt3a

DNA methyltransferase 3 alpha

protein:decreased expression:brain:

RGD

PMID:23716065

RGD:9588620

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

Egr1

early growth response 1

mRNA:increased expression:forebrain (rat)

RGD

PMID:7684483

RGD:2289081

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

Eif2s1

eukaryotic translation initiation factor 2 subunit alpha

RGD

PMID:8092984

RGD:10395352

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

Epha4

Eph receptor A4

protein:increased expression:brain

RGD

PMID:21736568

RGD:5688765

NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139

Epo

erythropoietin

treatment

PMID:24034924 PMID:22156696

RGD

RGD:10400911, RGD:10401072

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

Ero1a

endoplasmic reticulum oxidoreductase 1 alpha

mRNA:increased expression:hippocampus

RGD

PMID:12694393

RGD:632668

NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478

Fadd

Fas associated via death domain

treatment

RGD

PMID:29635023

RGD:13782292

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

Fas

Fas cell surface death receptor

RGD

PMID:21843499

RGD:9587791

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

Fos

Fos proto-oncogene, AP-1 transcription factor subunit

protein:decreased expression:hippocampus

RGD

PMID:25262910

RGD:405650622

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

Foxo3

forkhead box O3

protein:increased expression:cerebral cortex,nucleus:

RGD

PMID:24229603

RGD:10402203

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

Fst

follistatin

mRNA:decreased expression:brain (rat)

RGD

PMID:10415398

RGD:329322882

NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571

Ghr

growth hormone receptor

protein:increased expression:brain

RGD

PMID:19524466

RGD:2315620

NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735

Grin1

glutamate ionotropic receptor NMDA type subunit 1

mRNA:decreased expression:hippocampus (rat)

RGD

PMID:19761817

RGD:2325954

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

Grin2a

glutamate ionotropic receptor NMDA type subunit 2A

mRNA:decreased expression:hippocampus (rat)

RGD

PMID:19761817

RGD:2325954

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

Grin2b

glutamate ionotropic receptor NMDA type subunit 2B

mRNA:decreased expression:hippocampus (rat)

RGD

PMID:19761817

RGD:2325954

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

Gsn

gelsolin

severity

protein:decreased expression:blood plasma (human)

RGD

PMID:29466895

RGD:329333029

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

Hcn1

hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

mRNA:decreased expression:hippocampus,cortex:

RGD

PMID:19892002

RGD:9686395

NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774

Hdac3

histone deacetylase 3

protein:decreased expression:brain:

RGD

PMID:23716065

RGD:9588620

NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856

PMID:23694759 PMID:18210138 PMID:31784544 PMID:19595151

hypoxia inducible factor 1 subunit alpha

treatment

IEP
ISO
IDA

protein:increased expression:brain (rat)
mRNA, protein:increased expression:brain,kidney (rat)
CTD Direct Evidence: marker/mechanism

CTD
RGD

RGD:9068873, RGD:155882534, RGD:9068901

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

Hmox1

heme oxygenase 1

treatment

RGD

PMID:25447631

RGD:10766440

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

Hspa1a

heat shock protein family A (Hsp70) member 1A

PMID:11672597 PMID:23694759 PMID:19766709

RGD

PMID:22526757

RGD:7257595

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

Igf1

insulin-like growth factor 1

treatment

ISO
IDA
IEP

RGD

RGD:8549456, RGD:12904932, RGD:10046049

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

Igf2

insulin-like growth factor 2

disease_progression

RGD

PMID:16787587

RGD:5510005

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

Igfbp3

insulin-like growth factor binding protein 3

RGD

PMID:10709766

RGD:10402756

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

interleukin 1 beta

protein:increased expression:brain (rat)

RGD

PMID:23110519

RGD:7204438

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

interleukin 6

severity

DNA:polymorphism: :174G>C(human)

RGD

PMID:22117975

RGD:12792241

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Inhba

inhibin subunit beta A

severity
treatment

PMID:10415398 PMID:27957679 PMID:10415398

mRNA:increased expression:brain (rat)
mRNA, protein:increased expression:umbilical cord blood (human)
human construct in rat model

RGD

RGD:329322882, RGD:329849106, RGD:329322882

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

Irak1

interleukin-1 receptor-associated kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521

Irak4

interleukin-1 receptor-associated kinase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837

Ireb2

iron responsive element binding protein 2

mRNA:increased expression:brain (rat)

RGD

PMID:27602087

RGD:12903962

NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611

Kdr

kinase insert domain receptor

RGD

PMID:21277350

RGD:5684383

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

Map1lc3a

microtubule-associated protein 1 light chain 3 alpha

RGD

PMID:25919564

RGD:11558017

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

Map2

microtubule-associated protein 2

RGD

PMID:21300124

RGD:6483088

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

Map3k5

mitogen-activated protein kinase kinase kinase 5

RGD

PMID:21843499

RGD:9587791

NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800

Map3k7

mitogen activated protein kinase kinase kinase 7

ameliorates

PMID:29138854 PMID:32734729

protein:increased expression:brain (rat)

RGD

RGD:155804273, RGD:155804275

NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597

Mapt

microtubule-associated protein tau

treatment

RGD

PMID:25665755

RGD:13782373

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

Mbd2

methyl-CpG binding domain protein 2

protein:increased expression:brain:

RGD

PMID:23716065

RGD:9588620

NCBI chr18:64,174,002...64,240,795
Ensembl chr18:64,174,002...64,240,794

Mbp

myelin basic protein

protein:decreased expression:white matter:

RGD

PMID:23715956

RGD:7327196

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

Mir140

microRNA 140

severity

PMID:26875527 PMID:24089674 PMID:29568675 PMID:33402183

miRNA:decreased expression:blood serum (human)

RGD

PMID:34331407

RGD:329347831

NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675

microRNA 17

RGD

NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712

Mir210

microRNA 210

treatment
disease_progression

IMP
ISO

miRNA:decreased expression:blood serum (human)
associated with Brain Injuries;miRNA:increased expression:brain, cerebral hemisphere (human)

RGD

RGD:11572290, RGD:155882465, RGD:155598592, RGD:155582222

NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454

Mmp3

matrix metallopeptidase 3

treatment

RGD

PMID:21038694

RGD:8694100

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

Mpo

myeloperoxidase

protein:increased activity:brain:

RGD

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

Naglu

N-acetyl-alpha-glucosaminidase

protein:increased activity:brain:

RGD

NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972

Nos2

nitric oxide synthase 2

CTD Direct Evidence: marker/mechanism

PMID:23694759

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

Nrf1

nuclear respiratory factor 1

mRNA, protein:increase expression:cerebral cortex

RGD

PMID:18723421

RGD:2302400

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

Ntrk1

neurotrophic receptor tyrosine kinase 1

mRNA:increased expression:brain

RGD

PMID:19633950

RGD:5684358

NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770

Pdgfb

platelet derived growth factor subunit B

RGD

PMID:10215166

RGD:10449494

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

plasminogen activator, tissue type

onset

RGD

PMID:18467699

RGD:6483831

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

PMID:19587273 PMID:18467699

plasminogen activator, urokinase

IDA
IEP

mRNA, protein:increased expression, increased activity:hippocampus (rat)

RGD

RGD:2316117, RGD:6483831

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

Ppp1r1b

protein phosphatase 1, regulatory (inhibitor) subunit 1B

RGD

PMID:23153068

RGD:13515077

NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775

Prkdc

protein kinase, DNA-activated, catalytic subunit

treatment

RGD

PMID:30485360

RGD:39938998

NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952

Prkdc^em1Sage

protein kinase, DNA-activated, catalytic subunit; ZFN induced mutant 1, Sage

treatment

RGD

protein tyrosine phosphatase, non-receptor type 5

STEP33;protein:increased expression:forebrain (rat)

RGD

PMID:10537057

RGD:9835021

NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882

Ptprz1

protein tyrosine phosphatase, receptor type Z1

RGD

PMID:16041802

RGD:9590116

NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218

Rnf146

ring finger protein 146

RGD

PMID:28108258

RGD:13524865

NCBI chr 1:28,458,864...28,475,758
Ensembl chr 1:28,458,887...28,475,923

Robo1

roundabout guidance receptor 1

exacerbates

RGD

PMID:31356825

RGD:242905191

NCBI chr11:10,580,863...11,621,675
Ensembl chr11:10,580,908...11,620,203

S100b

S100 calcium binding protein B

severity

PMID:14707571 PMID:29568675

associated with Asphyxia Neonatorum;protein:increased expression:urine
protein:increased expression:blood serum (human)

RGD

RGD:5508819, RGD:155598592

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

serpin family E member 1

RGD

PMID:19587273

RGD:2316117

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

Slc9a1

solute carrier family 9 member A1

RGD

PMID:20883671

RGD:6771331

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

Slit2

slit guidance ligand 2

treatment

RGD

PMID:31356825

RGD:242905191

NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948

Spi1

Spi-1 proto-oncogene

protein:increased expression:CA1 field of hippocampus

RGD

PMID:10713349

RGD:9586724

NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393

Srgap1

SLIT-ROBO Rho GTPase activating protein 1

exacerbates

RGD

PMID:31356825

RGD:242905191

NCBI chr 7:57,329,532...57,594,681
Ensembl chr 7:57,329,532...57,596,196

Tert

telomerase reverse transcriptase

treatment

RGD

PMID:21940960

RGD:11038672

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

transferrin

treatment

RGD

PMID:22736466

RGD:7244383

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

Tfam

transcription factor A, mitochondrial

mRNA:increased expression:cerebral cortex

RGD

PMID:18723421

RGD:2302400

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

toll-like receptor 2

RGD

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

Trpc6

transient receptor potential cation channel, subfamily C, member 6

mRNA:increased expression:glomerular podocytes (rat)

RGD

PMID:31784544

RGD:155882534

NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092

Vegfa

vascular endothelial growth factor A

CTD Direct Evidence: marker/mechanism

PMID:31784544 PMID:34852714

PMID:23694759

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

Zeb2

zinc finger E-box binding homeobox 2

IEP
IMP

mRNA:increased expression:glomerular podocytes (rat)

RGD

RGD:155882534, RGD:155882542

NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157

brain infarction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Adipoq

adiponectin, C1Q and collagen domain containing

RGD

PMID:19362080

RGD:5686830

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

Adk

adenosine kinase

PMID:16685255 PMID:9731623

RGD

RGD:6482657, RGD:6482667

NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510

Adm

adrenomedullin

treatment

RGD

PMID:21695352

RGD:5508764

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

Adnp

activity-dependent neuroprotector homeobox

RGD

PMID:11935065

RGD:1358226

NCBI chr 3:156,886,921...156,921,500
Ensembl chr 3:156,891,381...156,917,312

Aif1

allograft inflammatory factor 1

PMID:19053043 PMID:10683518

protein:increased expression:brain subventricular zone (rat)
protein:increased expression:brain white matter (human)

RGD

RGD:2313025, RGD:2313026

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

Aldh2

aldehyde dehydrogenase 2 family member

susceptibility

RGD

PMID:17388993

RGD:1601161

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

Alox5ap

arachidonate 5-lipoxygenase activating protein

associated with Metabolic Syndrome X; DNA:polymorphism:g.162A>C rs4769055 (human)

RGD

PMID:18506375

RGD:2311309

NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986

Arrb2

arrestin, beta 2

protein:increased expression:spleen

RGD

PMID:29636059

RGD:401938621

NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850

Atp2b2

ATPase plasma membrane Ca2+ transporting 2

mRNA:decreased expression:brain (rat)

RGD

NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665

Becn1

beclin 1

protein:increased expression:brain

RGD

PMID:22227058

RGD:6483057

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

Cacna2d1

calcium voltage-gated channel auxiliary subunit alpha2delta 1

mRNA:decreased expression:brain (rat)

RGD

NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969

Calcrl

calcitonin receptor like receptor

mRNA:increased expression:brain (rat)

RGD

NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910

Cd8a

CD8 subunit alpha

mRNA:increased expression:brain (rat)

RGD

NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040

Cfh

complement factor H

treatment

RGD

PMID:21695352

RGD:5508764

NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838

Cort

cortistatin

mRNA:decreased expression:brain (rat)

RGD

NCBI chr 5:159,560,591...159,562,032

Ctsb

cathepsin B

protein:increased expression:cerebral cortical segment, cytoplasm (rat)

RGD

PMID:19941836

RGD:2315502

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

Cxcl10

C-X-C motif chemokine ligand 10

protein:increased expression:brain (rat)

RGD

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

Cybb

cytochrome b-245 beta chain

CTD Direct Evidence: marker/mechanism

PMID:19417757

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

Cyp11b1

cytochrome P450, family 11, subfamily b, polypeptide 1

mRNA:decreased expression:brain (rat)

RGD

NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278

Cyp2r1

cytochrome P450, family 2, subfamily r, polypeptide 1

DNA:variants:CDS:multiple (human)

RGD

PMID:36762557

RGD:401901151

NCBI chr 1:168,749,302...168,798,079
Ensembl chr 1:168,751,038...168,797,759

Dcx

doublecortin

protein:altered expression:brain (rat)

RGD

NCBI chr X:107,430,767...107,573,612
Ensembl chr X:107,430,767...107,507,476

Ece1

endothelin converting enzyme 1

RGD

PMID:15485550

RGD:1580908

NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371

Fgf2

fibroblast growth factor 2

CTD Direct Evidence: therapeutic

PMID:17524524

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

Gpnmb

glycoprotein nmb

mRNA:increased expression:brain (rat)

RGD

NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367

Gpr17

G protein-coupled receptor 17

CTD Direct Evidence: therapeutic

PMID:18974869

NCBI chr18:23,576,232...23,583,153
Ensembl chr18:23,577,242...23,582,966

Gzmb

granzyme B

protein:increased expression:brain (rat)

RGD

NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814

Hgf

hepatocyte growth factor

treatment

RGD

PMID:16421510

RGD:8548626

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

hypoxia inducible factor 1 subunit alpha

exacerbates

RGD

PMID:30052311

RGD:155663378

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

Hmgb1

high mobility group box 1

RGD

PMID:19944723

RGD:2316741

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

Hnmt

histamine N-methyltransferase

severity

PMID:21131122 PMID:16330002

RGD

RGD:5509772, RGD:5509773

NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012

Htr2b

5-hydroxytryptamine receptor 2B

mRNA:increased expression:brain (rat)

RGD

NCBI chr 9:86,735,793...86,756,638
Ensembl chr 9:86,742,102...86,755,108

Icam1

intercellular adhesion molecule 1

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:serum

RGD

PMID:18692933

RGD:2313474

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

Igf2

insulin-like growth factor 2

mRNA, protein:increased expression:brain

RGD

PMID:7770004

RGD:5509999

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

Il15

interleukin 15

associated with Hypertension;protein:increased expression:serum

RGD

PMID:16109314

RGD:1626610

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

interleukin 1 beta

protein:increased expression:cerebral cortex (rat)

RGD

PMID:17678971

RGD:1626644

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Il2

interleukin 2

protein:increased expression:brain (rat)

RGD

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

Kcnk6

potassium two pore domain channel subfamily K member 6

mRNA:increased expression:brain (rat)

RGD

NCBI chr 1:84,525,613...84,533,948
Ensembl chr 1:84,525,590...84,534,677

midkine

RGD

NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130

Meis2

Meis homeobox 2

protein:altered expression:brain (rat)

RGD

NCBI chr 3:102,742,904...102,944,833
Ensembl chr 3:102,742,900...102,949,696

Mgp

matrix Gla protein

mRNA:increased expression:brain (rat)

RGD

NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667

microRNA 223

RNA:increased expression:brain,blood

RGD

PMID:31342956

RGD:25824952

NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996

Mmp14

matrix metallopeptidase 14

mRNA:increased expression:brain (rat)

RGD

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

Mmp8

matrix metallopeptidase 8

mRNA:increased expression:brain (rat)

RGD

NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520

matrix metallopeptidase 9

RGD

PMID:16599837

RGD:1582617

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

Msi1

musashi RNA-binding protein 1

RGD

PMID:15250238

RGD:1582664

NCBI chr12:41,158,301...41,251,134
Ensembl chr12:41,158,599...41,191,076

Nes

nestin

associated with Hypertension

RGD

PMID:16321245

RGD:1642069

NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777

Parg

poly (ADP-ribose) glycohydrolase

associated with Reperfusion Injury

RGD

PMID:12834903

RGD:2316742

NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273

Pbx1

PBX homeobox 1

protein:altered expression:brain (rat)

RGD

NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594

Pdgfb

platelet derived growth factor subunit B

RGD

PMID:14980813

RGD:1581758

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

plasminogen activator, tissue type

CTD Direct Evidence: therapeutic

PMID:16190367

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

Ppp1r1b

protein phosphatase 1, regulatory (inhibitor) subunit 1B

protein:altered expression:brain (rat)

RGD

NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775

Prcp

prolylcarboxypeptidase

mRNA:increased expression:brain (rat)

RGD

NCBI chr 1:146,931,487...146,983,891
Ensembl chr 1:146,930,561...146,984,530

Rbfox3

RNA binding fox-1 homolog 3

protein:altered expression:brain (rat)

RGD

NCBI chr10:103,720,355...104,157,277
Ensembl chr10:103,720,636...104,156,935

RT1-Ba

RT1 class II, locus Ba

DNA:polymorphisms (human)

RGD

PMID:11798899

RGD:5147807

NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744

Scn7a

sodium voltage-gated channel alpha subunit 7

mRNA:increased expression:brain (rat)

RGD

NCBI chr 3:51,335,841...51,438,308
Ensembl chr 3:51,335,841...51,438,256

Sirt1

sirtuin 1

CTD Direct Evidence: marker/mechanism

PMID:22878646

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

Tbxas1

thromboxane A synthase 1

RGD

PMID:14650360

RGD:1601455

NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096

tumor necrosis factor

protein:increased expression:brain (rat)

RGD

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tpcn2

two pore segment channel 2

mRNA:increased expression:brain (rat)

RGD

NCBI chr 1:200,416,538...200,446,252
Ensembl chr 1:200,416,540...200,446,236

brain ischemia

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Abcb1b

ATP-binding cassette, sub-family B member 1B

RGD

PMID:15049514

RGD:1598554

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

Ace

angiotensin I converting enzyme

CTD Direct Evidence: marker/mechanism

PMID:15534175

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

Adamts1

ADAM metallopeptidase with thrombospondin type 1 motif, 1

mRNA:increased expression:brain

RGD

PMID:17073862

RGD:9681750

NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103

Add3

adducin 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124

Adk

adenosine kinase

PMID:21427729 PMID:17457365

RGD

RGD:6482652, RGD:6482655

NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510

advanced glycosylation end product-specific receptor

mRNA:increased expression:pyramidal cell, hippocampus

RGD

PMID:12618340

RGD:1625348

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

Aif1

allograft inflammatory factor 1

protein:increased expression:cerebral cortex (rat)

RGD

PMID:18301954

RGD:2313032

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

Akap1

A-kinase anchoring protein 1

protein:altered expression:parietal cortex, hippocampus (rat)

RGD

PMID:18323779

RGD:2313128

NCBI chr10:73,621,021...73,654,123
Ensembl chr10:73,621,883...73,653,896

Akap12

A-kinase anchoring protein 12

RGD

PMID:21334414

RGD:14348963

NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886

Akt1

AKT serine/threonine kinase 1

protein:decreased serine phosphorylation:cerebral cortex

RGD

PMID:21596097

RGD:5509066

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

Alb

albumin

CTD Direct Evidence: therapeutic

PMID:16809570

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

Alox15

arachidonate 15-lipoxygenase

mRNA, protein:increased expression:brain

RGD

PMID:20167207

RGD:5509598

NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874

Alox5

arachidonate 5-lipoxygenase

RGD

PMID:20204486

RGD:2317525

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

angiopoietin 1

RGD

NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067

angiopoietin 2

RGD

NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804

Anxa1

annexin A1

treatment

PMID:1830327 PMID:1830327

RGD

RGD:7421662, RGD:7421662

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

Apaf1

apoptotic peptidase activating factor 1

protein:increased expression:striatum

RGD

PMID:17640469

RGD:2325742

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

Apex1

apurinic/apyrimidinic endodeoxyribonuclease 1

protein:decreased expression:hippocampus CA1, neuron

RGD

PMID:9030714

RGD:2315686

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

Aqp3

aquaporin 3 (Gill blood group)

RGD

PMID:19616516

RGD:5490152

NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720

aquaporin 4

RGD

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

aquaporin 5

RGD

NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209

aquaporin 8

RGD

NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158

Asic1

acid sensing ion channel subunit 1

CTD Direct Evidence: marker/mechanism

PMID:21307247

NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541

Bad

BCL2-associated agonist of cell death

PMID:18078455 PMID:22843461

protein:decreased serine phosphorylation:brain

RGD

RGD:2292681, RGD:10053716

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

Bbc3

Bcl-2 binding component 3

CTD Direct Evidence: marker/mechanism

PMID:19095966

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

Bcl2

BCL2, apoptosis regulator

treatment

RGD

PMID:15585409

RGD:11522731

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

Bcl2l1

Bcl2-like 1

PMID:17706879 PMID:22843461

protein:increased expression:cerebral cortex

RGD

RGD:1643491, RGD:10053716

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

Bdnf

brain-derived neurotrophic factor

CTD Direct Evidence: marker/mechanism

PMID:19574998 PMID:17936001

PMID:19922383

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

Becn1

beclin 1

IMP
IEP

protein:increased expression:hippocampus, frontal cortex

RGD

RGD:6483094, RGD:6483313

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

Bmp6

bone morphogenetic protein 6

RGD

PMID:11245809

RGD:2289024

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

Btg2

BTG anti-proliferation factor 2

mRNA:increased expression:forebrain (rat)

RGD

PMID:7684483

RGD:2289081

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

complement C3

protein:increased expression:brain

RGD

PMID:14561876

RGD:5129543

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

Casp12

caspase 12

mRNA, protein:increased expresssion:brain

RGD

PMID:12598725

RGD:1299333

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

Casp3

caspase 3

CTD Direct Evidence: marker/mechanism

PMID:11756504 PMID:17901229

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Casp6

caspase 6

mRNA:increased expression:cerebral cortex

RGD

PMID:11311984

RGD:2301331

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

Casp9

caspase 9

CTD Direct Evidence: marker/mechanism

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

calpastatin

RGD

NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659

Cat

catalase

PMID:17564305 PMID:21213399

CTD Direct Evidence: marker/mechanism

CTD
RGD

RGD:5130891

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

caveolin 1

RGD

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

Ccl11

C-C motif chemokine ligand 11

CTD Direct Evidence: marker/mechanism

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

Ccl12

C-C motif chemokine ligand 12

CTD Direct Evidence: marker/mechanism

NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780

C-C motif chemokine ligand 2

PMID:15829914 PMID:17394460 PMID:19260320

CTD Direct Evidence: marker/mechanism

CTD
RGD

RGD:2306998

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

Ccl20

C-C motif chemokine ligand 20

mRNA:increased expression:cerebral cortex

RGD

PMID:9916893

RGD:69987

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

Ccl3

C-C motif chemokine ligand 3

CTD Direct Evidence: marker/mechanism

PMID:15829914 PMID:17394460

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

Ccl4

C-C motif chemokine ligand 4

CTD Direct Evidence: marker/mechanism

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

Ccr4

C-C motif chemokine receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056

Ccr5

C-C motif chemokine receptor 5

mRNA:increased expression:brain (rat)

RGD

PMID:9670989

RGD:632396

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

CD36 molecule

RGD

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

Cdk5

cyclin-dependent kinase 5

RGD

PMID:14502288

RGD:734740

NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112

Cebpb

CCAAT/enhancer binding protein beta

CTD Direct Evidence: marker/mechanism

PMID:17394460

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

Chrm1

cholinergic receptor, muscarinic 1

CTD Direct Evidence: marker/mechanism

PMID:18501976

NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356

Cited2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

RGD

PMID:16434029

RGD:1581188

NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897

clusterin

RGD

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

ceruloplasmin

mRNA, protein:decreased expression:cerebral cortex, hippocampus

RGD

PMID:18273071

RGD:2314688

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

Creb1

cAMP responsive element binding protein 1

treatment

mRNA,protein:decreased expression,decreased phosphorylation:brain:

RGD

PMID:23644141

RGD:10059580

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

Crh

corticotropin releasing hormone

mRNA:increased expression:cerebral cortex (rat)

RGD

PMID:8541482

RGD:1581300

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

Csf2rb

colony stimulating factor 2 receptor subunit beta

mRNA:increased expression:brain

RGD

PMID:7643220

RGD:632531

NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157

Csf3

colony stimulating factor 3

associated with Diabetes Mellitus, Experimental

RGD

PMID:18832793

RGD:2311241

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

Cspg4

chondroitin sulfate proteoglycan 4

RGD

PMID:21864831

RGD:5686850

NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010

Cst3

cystatin C

protein:decreased expression:cerebrospinal fluid

RGD

PMID:18261165

RGD:2314349

NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822

Ctsb

cathepsin B

protein:increased activity:cerebrum (rat)

RGD

PMID:18404379

RGD:2315571

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

Ctsc

cathepsin C

mRNA:increased expression:cerebral cortex

RGD

PMID:12843783

RGD:1599640

NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387

Ctsl

cathepsin L

protein:increased activity:cerebrum (rat)

RGD

PMID:18404379

RGD:2315571

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

Cxcl10

C-X-C motif chemokine ligand 10

PMID:15829914 PMID:17549754

mRNA:increased expression:brain
CTD Direct Evidence: marker/mechanism

CTD
RGD

RGD:2311381

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

Cxcl12

C-X-C motif chemokine ligand 12

mRNA, protein:increased expression:brain

RGD

PMID:18206136

RGD:2306577

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

Cycs

cytochrome c, somatic

CTD Direct Evidence: marker/mechanism

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

Dbh

dopamine beta-hydroxylase

protein:decreased expression:forebrain (rat)

RGD

PMID:18356740

RGD:5129691

NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248

Ddit3

DNA-damage inducible transcript 3

Protein:increased expression:brain

RGD

PMID:15921666

RGD:1599731

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

Diablo

diablo, IAP-binding mitochondrial protein

CTD Direct Evidence: marker/mechanism

NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387

Dpysl2

dihydropyrimidinase-like 2

mRNA:increased expression:brain

RGD

PMID:19524114

RGD:2316241

NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829

dopamine receptor D2

RGD

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

Dusp6

dual specificity phosphatase 6

mRNA:increased expression:brain

RGD

PMID:10908038

RGD:2316092

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

Dynll1

dynein light chain LC8-type 1

CTD Direct Evidence: marker/mechanism

PMID:9522364

NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741

Edn1

endothelin 1

protein:increased expression:cerebral cortex (rat)

RGD

PMID:8113329

RGD:4144887

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

Egr1

early growth response 1

CTD Direct Evidence: marker/mechanism

PMID:17394460

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

endonuclease G

RGD

NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932

Epor

erythropoietin receptor

protein:increased expression:brain:

RGD

PMID:14732457

RGD:11041652

NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257

Esr2

estrogen receptor 2

mRNA:decreased expression:cerebral cortex, ipsilateral side (rat)

RGD

PMID:10414967

RGD:8694344

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

coagulation factor II, thrombin

CTD Direct Evidence: marker/mechanism

PMID:14753426 PMID:15534175

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

F2r

coagulation factor II (thrombin) receptor

RGD

PMID:14705148

RGD:1302269

NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870

coagulation factor V

CTD Direct Evidence: marker/mechanism

PMID:15534175

NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317

Fas

Fas cell surface death receptor

protein:increased expression:brain

RGD

PMID:16796407

RGD:1600333

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

Faslg

Fas ligand

protein:increased expression:brain

RGD

PMID:18410517

RGD:2311437

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

Fga

fibrinogen alpha chain

treatment

RGD

PMID:22737923

RGD:11040923

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

Fgf1

fibroblast growth factor 1

PMID:19497570 PMID:16635575

Rat model using human FGF1

RGD

RGD:5509879, RGD:5509881

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

Gal

galanin and GMAP prepropeptide

RGD

PMID:16458372

RGD:1624341

NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959

GC, vitamin D binding protein

protein:increased expression:urine

RGD

PMID:11239198

RGD:1625796

NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567

Gfra1

GDNF family receptor alpha 1

protein:increased expression:cerebral cortex

RGD

PMID:10407114

RGD:6218981

NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473

Gja1

gap junction protein, alpha 1

protein:increased expression:cerebral cortex

RGD

PMID:21718970

RGD:6480433

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

Glud1

glutamate dehydrogenase 1

protein:decreased activity:brain

RGD

PMID:7808037

RGD:6484655

NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957

Gp1ba

glycoprotein Ib platelet subunit alpha

exacerbates

associated with Pneumococcal Infections

RGD

PMID:24644058

RGD:42722626

NCBI chr10:55,352,938...55,355,804
Ensembl chr10:55,352,899...55,356,774

Gpx1

glutathione peroxidase 1

CTD Direct Evidence: therapeutic

PMID:12531513

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

glutathione peroxidase 3

protein:increased expression:plasma

RGD

PMID:30025402

RGD:401827828

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

PMID:19429140 PMID:17554006 PMID:18369388 PMID:17101276

hypoxia inducible factor 1 subunit alpha

treatment

ISO
IDA
IEP

protein:increased expression:brain
CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:cerebral cortex (rat)

CTD
RGD

RGD:1626331, RGD:9068895, RGD:9068892

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

Hmox1

heme oxygenase 1

IEP
IMP

RGD

PMID:16464361 PMID:21276833

RGD:1582709, RGD:10755576

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

Hspa1b

heat shock protein family A (Hsp70) member 1B

associated with advanced age and Diabetes Mellitus, Type 2 (MeSH:D003924)

RGD

PMID:15992611

RGD:1626649

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

Hspa8

heat shock protein family A (Hsp70) member 8

RGD

PMID:16805800

RGD:6480229

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

Hspa9

heat shock protein family A (Hsp70) member 9

mRNA:increased expression:brain

RGD

PMID:7629893

RGD:6784525

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

Icam1

intercellular adhesion molecule 1

CTD Direct Evidence: marker/mechanism

PMID:17394460 PMID:19417757

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

Igf1

insulin-like growth factor 1

PMID:16882007 PMID:19332057

RGD

RGD:1598411, RGD:2306694

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

Il10rb

interleukin 10 receptor subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr11:30,646,494...30,668,081
Ensembl chr11:30,652,096...30,668,074

Il12rb1

interleukin 12 receptor subunit beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769

Il17a

interleukin 17A

PMID:15829914 PMID:16305645 PMID:16305645

protein, mRNA:increased expression:brain
CTD Direct Evidence: marker/mechanism
protein:increased expression:brain

CTD
RGD

RGD:4846398, RGD:4846398

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

Il17ra

interleukin 17 receptor A

CTD Direct Evidence: marker/mechanism

NCBI chr 4:153,667,534...153,690,174
Ensembl chr 4:153,667,534...153,690,174

Il18

interleukin 18

PMID:15829914 PMID:11807395

mRNA:increased expression:brain
CTD Direct Evidence: marker/mechanism

CTD
RGD

RGD:4889510

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

Il1a

interleukin 1 alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

interleukin 1 beta

CTD Direct Evidence: marker/mechanism

PMID:9236716 PMID:15737438 PMID:15756928 PMID:17394460

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Il1rn

interleukin 1 receptor antagonist

CTD Direct Evidence: therapeutic

PMID:9236716

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

interleukin 6

CTD Direct Evidence: marker/mechanism

PMID:15829914 PMID:17394460

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Il6st

interleukin 6 cytokine family signal transducer

mRNA:increased expression:brain, astrocyte

RGD

PMID:15469886

RGD:1627568

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

Irak1

interleukin-1 receptor-associated kinase 1

mRNA, protein:increased expression:cerebral cortex

RGD

RGD:7495802

NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521

Irak4

interleukin-1 receptor-associated kinase 4

mRNA, protein:increased expression:cerebral cortex

RGD

RGD:7495802

NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837

Itgam

integrin subunit alpha M

associated with Hypotension;protein:increased expression:pyramidal layer of CA1 (rat)

RGD

PMID:19019197

RGD:329853772

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

Jun

Jun proto-oncogene, AP-1 transcription factor subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

Kcnk10

potassium two pore domain channel subfamily K member 10

mRNA, protein:increased expression:cerebral cortex, hippocampus (rat)

RGD

PMID:15652517

RGD:9831167

NCBI chr 6:117,690,052...117,826,120
Ensembl chr 6:117,694,222...117,825,695

Kcnk2

potassium two pore domain channel subfamily K member 2

mRNA:increased expression:hippocampus (rat)

RGD

PMID:14741413

RGD:9831127

NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435

Kdr

kinase insert domain receptor

RGD

PMID:18951929

RGD:5684407

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

galectin 3

RGD

NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025

Lif

LIF, interleukin 6 family cytokine

mRNA:increased expression:brain

RGD

PMID:20221422

RGD:2326053

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

Lonp1

lon peptidase 1, mitochondrial

RGD

PMID:12082077

RGD:633879

NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771

Map2

microtubule-associated protein 2

protein:increased expression:serum

RGD

PMID:21948028

RGD:6483082

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

Map2k1

mitogen activated protein kinase kinase 1

PMID:17901229 PMID:10536014

CTD Direct Evidence: marker/mechanism

CTD
RGD

RGD:1582169

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

Map3k7

mitogen activated protein kinase kinase kinase 7

treatment

RGD

PMID:21475303

RGD:155882442

NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597

Mapk1

mitogen activated protein kinase 1

PMID:17901229 PMID:15669185

CTD Direct Evidence: marker/mechanism

CTD
RGD

RGD:1582281

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

Mapk3

mitogen activated protein kinase 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

Mapk8

mitogen-activated protein kinase 8

RGD

PMID:15797868

RGD:1582325

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

Mapt

microtubule-associated protein tau

protein:increased phosphorylation

RGD

PMID:15353210

RGD:1599927

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

Mdh2

malate dehydrogenase 2

RGD

PMID:6282622

RGD:1582465

NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271

midkine

RGD

NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130

microRNA 223

treatment

RGD

PMID:31791013

RGD:26884340

NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996

Mmp13

matrix metallopeptidase 13

RGD

PMID:16112096

RGD:1582554

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

Mmp14

matrix metallopeptidase 14

RGD

PMID:15963646

RGD:1582577

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

Mmp2

matrix metallopeptidase 2

RGD

PMID:15963646

RGD:1582577

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

matrix metallopeptidase 9

PMID:15060315 PMID:16846501

CTD Direct Evidence: marker/mechanism

CTD
RGD

RGD:1582611

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

Mpo

myeloperoxidase

CTD Direct Evidence: marker/mechanism

PMID:19417757

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

Msi1

musashi RNA-binding protein 1

RGD

PMID:12205668

RGD:633285

NCBI chr12:41,158,301...41,251,134
Ensembl chr12:41,158,599...41,191,076

Mthfr

methylenetetrahydrofolate reductase

CTD Direct Evidence: marker/mechanism

PMID:15534175

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

Naip6

NLR family, apoptosis inhibitory protein 6

protein:increased expression:thalamus (rat)

RGD

PMID:9288726

RGD:2317254

NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542

Nes

nestin

protein:increased expression:hippocampus

RGD

PMID:17697621

RGD:1642071

NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777

Nfkb1

nuclear factor kappa B subunit 1

CTD Direct Evidence: therapeutic

PMID:18628779

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

Nfkbia

NFKB inhibitor alpha

CTD Direct Evidence: marker/mechanism

PMID:17451676 PMID:21718970

PMID:18628779

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

Nos1

nitric oxide synthase 1

IMP
IEP

protein:decreased expression:hippocampus

RGD

RGD:1642142, RGD:6480433

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

Nos2

nitric oxide synthase 2

CTD Direct Evidence: marker/mechanism

PMID:9778187 PMID:17394460

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

PMID:21212863 PMID:17600658

nitric oxide synthase 3

IDA
IMP

RGD

RGD:4891961, RGD:2292134

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

Nox4

NADPH oxidase 4

mRNA, protein:increased expression:cerebral cortex (human)

RGD

PMID:15802177

RGD:1580980

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

Nppa

natriuretic peptide A

no_association

RGD

PMID:11706124

RGD:1626244

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

Nptxr

neuronal pentraxin receptor

mRNA:decreased expression:neocortex

RGD

PMID:12242102

RGD:1642302

NCBI chr 7:111,336,660...111,354,737
Ensembl chr 7:111,336,664...111,354,802

Nr3c1

nuclear receptor subfamily 3, group C, member 1

protein:decreased expression:brain cortex

RGD

PMID:17344647

RGD:4892115

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

Oaz1

ornithine decarboxylase antizyme 1

mRNA:altered expression:cerebral cortex (rat)

RGD

PMID:19531214

RGD:401851038

NCBI chr 7:8,883,855...8,886,315
Ensembl chr 7:8,883,851...8,886,310

Oprm1

opioid receptor, mu 1

RGD

PMID:16176345

RGD:2316630

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

Pak1

p21 (RAC1) activated kinase 1

protein:increased expression:brain

RGD

PMID:17997827

RGD:2299171

NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383

Parp1

poly (ADP-ribose) polymerase 1

CTD Direct Evidence: marker/mechanism

PMID:17640816

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

Pcna

proliferating cell nuclear antigen

protein:increased expression:brain

RGD

PMID:12099899

RGD:729592

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

Pgf

placental growth factor

RGD

PMID:16901914

RGD:6483783

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

Pla2g4a

phospholipase A2 group 4A

mRNA:increased expression:hippocampus

RGD

PMID:15306117

RGD:1642465

NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266

plasminogen activator, tissue type

no_association

DNA:polymorphism:-7351C>T (human)
CTD Direct Evidence: therapeutic

CTD
RGD

PMID:7477192 PMID:9259745 PMID:9400355 PMID:9479658 PMID:9566367 More...

RGD:1580879

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

plasminogen activator, urokinase

CTD Direct Evidence: therapeutic

PMID:9731615 PMID:10472989 PMID:10512912 PMID:17927297

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

Ppbp

pro-platelet basic protein

RGD

PMID:26307429

RGD:11553187

NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130

Ppid

peptidylprolyl isomerase D

RGD

PMID:16103352

RGD:1580699

NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221

Ppp1r15a

protein phosphatase 1, regulatory subunit 15A

protein:increased expression:cerebral cortex, caudate nucleus (rat)

RGD

PMID:15713259

RGD:9999408

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

Prkaca

protein kinase cAMP-activated catalytic subunit alpha

protein:decreased expression:hippocampus, cerebral cortex, nucleus

RGD

PMID:12150772

RGD:7327190

NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430

Prkacb

protein kinase cAMP-activated catalytic subunit beta

protein:decreased expression:hippocampus, cerebral cortex, cytosol, nucleus

RGD

PMID:12150772

RGD:7327190

NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198

Prkca

protein kinase C, alpha

associated with Subarachnoid Hemorrhage;protein:increased phosphorylation:cerebral artery

RGD

PMID:18032736

RGD:2293301

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

Prkcd

protein kinase C, delta

RGD

PMID:17350602

RGD:1642524

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

Proz

protein Z, vitamin K-dependent plasma glycoprotein

RGD

PMID:14671240

RGD:1358564

NCBI chr16:76,450,013...76,463,558
Ensembl chr16:76,450,013...76,463,480

Ptgis

prostaglandin I2 synthase

RGD

PMID:16094316

RGD:8693629

NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451

Ptgs1

prostaglandin-endoperoxide synthase 1

PMID:11740205 PMID:10867793

protein:increased expression:microglia, macrophage

RGD

RGD:5688240, RGD:5688247

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

Ptgs2

prostaglandin-endoperoxide synthase 2

IEP
ISO
IDA

protein:increased expression:hippocampus
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:15737438 PMID:17394460 PMID:17564305 PMID:19417757 PMID:21718970 More...

RGD:6480433, RGD:5688292, RGD:1581286

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

Ptk2b

protein tyrosine kinase 2 beta

protein:increased tyrosine phosphorylation:cerebral cortex

RGD

PMID:10964954

RGD:1642647

NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282

Rb1

RB transcriptional corepressor 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

Rela

RELA proto-oncogene, NF-kB subunit

CTD Direct Evidence: therapeutic

PMID:18628779

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

Ret

ret proto-oncogene

protein:increased expression:cerebral cortex

RGD

PMID:10407114

RGD:6218981

NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176

S100b

S100 calcium binding protein B

protein:increased expression:serum

RGD

PMID:21695352

RGD:5508764

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

Scn5a

sodium voltage-gated channel alpha subunit 5

RGD

PMID:19471098

RGD:6484225

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

Sele

selectin E

PMID:17394460 PMID:19107136

associated with Hypertension
CTD Direct Evidence: marker/mechanism

CTD
RGD

RGD:2313600

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

serpin family E member 1

treatment

RGD

PMID:27108052

RGD:11073613

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

Slc11a2

solute carrier family 11 member 2

protein:increased expression:brain

RGD

PMID:21325818

RGD:5688411

NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145

Slc29a1

solute carrier family 29 member 1

RGD

PMID:15829178

RGD:2316942

NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203

Slc6a1

solute carrier family 6 member 1

PMID:17662498 PMID:22036625 PMID:12377375

RGD

PMID:15084665

RGD:1643209

NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293

Slc8a1

solute carrier family 8 member A1

IEP
IMP

protein:increased expression:brain
mRNA:decreased expression:cerebral cortex (rat)

RGD

RGD:1642717, RGD:6771236, RGD:727449

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

Slc8a2

solute carrier family 8 member A2

RGD

PMID:16107787

RGD:2316979

NCBI chr 1:76,816,583...76,852,928
Ensembl chr 1:76,808,725...76,847,072

Slc8a3

solute carrier family 8 member A3

RGD

PMID:16107787

RGD:2316979

NCBI chr 6:100,874,359...101,007,989
Ensembl chr 6:100,874,369...101,007,508

Sod1

superoxide dismutase 1

CTD Direct Evidence: therapeutic

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

superoxide dismutase 2

PMID:15060315 PMID:17901229 PMID:19429140 PMID:10212301

CTD Direct Evidence: marker/mechanism

CTD
RGD

RGD:1625695

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

Sod3

superoxide dismutase 3

RGD

PMID:10833313

RGD:1580852

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

Sos1

SOS Ras/Rac guanine nucleotide exchange factor 1

RGD

PMID:26442853

RGD:155630597

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

Src

SRC proto-oncogene, non-receptor tyrosine kinase

RGD

PMID:15854740

RGD:1581411

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

Stat3

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

Tek

TEK receptor tyrosine kinase

RGD

PMID:11919509

RGD:634324

NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804

Tgfb1

transforming growth factor, beta 1

mRNA:increased expression:brain

RGD

PMID:14997937

RGD:2302105

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

tyrosine hydroxylase

protein:decreased expression:solitary tract nucleus, medulla oblongata, locus coeruleus (rat)

RGD

PMID:18356740

RGD:5129691

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

Tjp1

tight junction protein 1

protein:decreased expression:brain

RGD

PMID:19712057

RGD:2325131

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

Tlr4

toll-like receptor 4

no_association

DNA:polymorphisms: :p.N299G, p.T399I (human)

RGD

PMID:15258789

RGD:1580737

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

tumor necrosis factor

CTD Direct Evidence: marker/mechanism

PMID:15756928

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tnfrsf1a

TNF receptor superfamily member 1A

PMID:15829914 PMID:16442237

CTD Direct Evidence: marker/mechanism

CTD
RGD

RGD:1624184

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

Tnfrsf1b

TNF receptor superfamily member 1B

CTD Direct Evidence: marker/mechanism

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

Tp53

tumor protein p53

CTD Direct Evidence: marker/mechanism

PMID:19095966

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

transthyretin

RGD

NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008

Ucp2

uncoupling protein 2

CTD Direct Evidence: marker/mechanism

PMID:17052689

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

Vip

vasoactive intestinal peptide

RGD

PMID:18158987

RGD:5685617

NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216

Ywhab

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

protein:increased expression:cerebrospinal fluid

RGD

PMID:15902199

RGD:2306031

NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105

Cardiac Allograft Vasculopathy

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

coagulation factor III, tissue factor

RGD

PMID:9916935

RGD:11341701

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

Hnrnpk

heterogeneous nuclear ribonucleoprotein K

RGD

PMID:21489814

RGD:155260371

NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997

Pdgfd

platelet derived growth factor D

RGD

PMID:19213942

RGD:9854642

NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395

Cardiogenic Shock

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Epo

erythropoietin

CTD Direct Evidence: marker/mechanism

PMID:19337937

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

plasminogen activator, tissue type

CTD Direct Evidence: therapeutic

PMID:1430592

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

PMID:21062213

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Htra1

HtrA serine peptidase 1

ClinVar Annotator: match by term: CARASIL | ClinVar Annotator: match by term: CARASIL syndrome | ClinVar Annotator: match by term: Cerebrovascular disease with thin skin, alopecia, and disc disease | ClinVar Annotator: match by term: HTRA1-related cerebral small vessel disease

OMIM
ClinVar

PMID:11889251 PMID:18316707 PMID:19387015 PMID:20437615 PMID:21115960 More...

NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379

Pura

purine rich element binding protein A

ClinVar Annotator: match by term: Cerebrovascular disease with thin skin, alopecia, and disc disease

PMID:24500651 PMID:27148565

NCBI chr18:27,885,071...27,905,509
Ensembl chr18:27,884,556...27,905,513

cerebral infarction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

A2m

alpha-2-macroglobulin

disease_progression

RGD

PMID:28266892

RGD:13702087

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

Ace

angiotensin I converting enzyme

DNA:deletion:intron:IVS16+1464-1751del (human)
ClinVar Annotator: match by term: Ischemic stroke, susceptibility to

ClinVar
RGD

PMID:1313972 PMID:1319114 PMID:1328889 PMID:1386652 PMID:1976655 More...

RGD:11038922

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

Adora1

adenosine A1 receptor

RGD

PMID:17067559

RGD:1625229

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

advanced glycosylation end product-specific receptor

protein:increased expression:plasma

RGD

PMID:23288172

RGD:8696004

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

Agxt2

alanine-glyoxylate aminotransferase 2

onset

DNA:missense mutation:cds:V498L (rs16899974) (human)

RGD

PMID:26984639

RGD:329961314

NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926

Ahsp

alpha hemoglobin stabilizing protein

mRNA:increased expression:venous blood (human)

RGD

PMID:29284304

RGD:329961296

NCBI chr 1:182,879,901...182,885,508
Ensembl chr 1:182,880,076...182,885,506

Alox5ap

arachidonate 5-lipoxygenase activating protein

susceptibility

OMIM

NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986

Ang

angiogenin

severity

protein:increased expression:serum

RGD

PMID:17823536

RGD:6892714

NCBI chr15:24,312,711...24,323,361

Anxa1

annexin A1

treatment

associated with Ischemic Attack, Transient

RGD

PMID:22617647

RGD:7483559

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

Apoa5

apolipoprotein A5

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :-1131T>C (human)

RGD

PMID:19107359

RGD:2313314

NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816

Apob

apolipoprotein B

protein:increased expression:serum

RGD

PMID:2352345

RGD:2313973

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

Apoe

apolipoprotein E

susceptibility

DNA:polymorphism: :3932T>C (human)

RGD

PMID:17016617

RGD:1601237

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

Bhmt

betaine-homocysteine S-methyltransferase

susceptibility

DNA:SNPs,haplotypes:multiple

RGD

NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742

Brinp3

BMP/retinoic acid inducible neural specific 3

associated with diabetes mellitus;mRNA:protein:increased expression:blood mononuclear cell:

RGD

PMID:26717922

RGD:14398486

NCBI chr13:58,413,883...58,846,828
Ensembl chr13:58,413,883...58,846,770

Cbs

cystathionine beta synthase

susceptibility

DNA:SNPs,haplotypes:multiple

RGD

NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764

C-C motif chemokine ligand 2

treatment

RGD

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

Ccl3

C-C motif chemokine ligand 3

treatment

RGD

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

Ccr5

C-C motif chemokine receptor 5

RGD

PMID:23602964

RGD:8552262

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

Cd36

CD36 molecule

associated with Hyperlipidemias

RGD

PMID:22718544

RGD:6893487

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

epoxide hydrolase 2

RGD

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

coagulation factor II, thrombin

susceptibility

ClinVar Annotator: match by term: Ischemic stroke | ClinVar Annotator: match by term: Ischemic stroke, susceptibility to

ClinVar
OMIM

PMID:2222810 PMID:2429850 PMID:2825773 PMID:6305407 PMID:8696333 More...

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

coagulation factor V

susceptibility

ClinVar Annotator: match by term: Ischemic stroke, susceptibility to

ClinVar
OMIM

PMID:7586244 PMID:7803250 PMID:7877648 PMID:7910348 PMID:7911872 More...

NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317

coagulation factor VII

treatment

PMID:14733777 PMID:21998055

protein:increased expression, increased activity:plasma (human)
human protein in a mouse model

RGD

RGD:11049518, RGD:11049520

NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610

Fbn1

fibrillin 1

ClinVar Annotator: match by term: Ischemic stroke

PMID:7611299 PMID:8894692 PMID:9401003 PMID:9536098 PMID:10533071 More...

NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889

Folh1

folate hydrolase 1

susceptibility

DNA:SNPs,haplotypes:multiple

RGD

NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379

Gch1

GTP cyclohydrolase 1

exacerbates
treatment

PMID:21181356 PMID:16282548 PMID:21963893

DNA:SNP:3' UTR:+243C>T (human)
DNA:SNP, haplotype:rs841 (human)

RGD

RGD:329961322, RGD:329961574, RGD:329961572

NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698

Gp6

glycoprotein VI

ameliorates

RGD

PMID:34237320

RGD:401794450

NCBI chr 1:69,429,232...69,492,709
Ensembl chr 1:69,465,789...69,491,326

glutathione peroxidase 3

susceptibility

PMID:25126700 PMID:20946167 PMID:17122425

DNA, protein:SNP,decreased expression:promoter,plasma:-861A>T (human)
DNA:SNPs, haplotypes:promoter:rs8177412, rs870407, rs870406 (human)
DNA:SNPs, haplotype:promoter:-942 A>C, -927 T>C, -861 A>T, -302 A>T, -284 T>A, -568 T>C, -518 T>C, -65 T>C (human)

RGD

RGD:401827128, RGD:401827165, RGD:401827163

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

Grin1

glutamate ionotropic receptor NMDA type subunit 1

severity

RGD

PMID:23723305

RGD:13792693

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

Grn

granulin precursor

ClinVar Annotator: match by term: Ischemic stroke

PMID:18723524 PMID:28492532

NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775

Gsn

gelsolin

severity

protein:decreased expression:blood plasma (human)

RGD

PMID:21481565

RGD:329337334

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

H19

H19 imprinted maternally expressed transcript

disease_progression
susceptibility
ameliorates

PMID:36453417 PMID:33541284 PMID:28203482 PMID:30778327 PMID:36453417

RNA:increased expression:blood plasma, plasma exosome (human)
DNA:SNP::(rs217727) (human)
DNA:SNPs,haplotypes: (rs217727,rs4929984) (human)
associated with atherosclerosis

RGD

RGD:155882574, RGD:156430336, RGD:155900760, RGD:155900761, RGD:155882574

NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134

Hba-a2

hemoglobin alpha, adult chain 2

CTD Direct Evidence: marker/mechanism

PMID:1634355

NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392

hypoxia inducible factor 1 subunit alpha

severity

protein:increased expression:blood serum (human)

RGD

PMID:34708885

RGD:155260326

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

Hmgb1

high mobility group box 1

protein:increased expression:plasma

RGD

PMID:23288172

RGD:8696004

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

heme oxygenase 1

RGD

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

Hnf1a

HNF1 homeobox A

susceptibility

DNA:SNPs,haplotypes:multiple

RGD

PMID:28035729

RGD:329901837

NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104

Icam1

intercellular adhesion molecule 1

PMID:31810024 PMID:16514094

mRNA, protein:increased expression:cerebral cortex

RGD

PMID:20083630

RGD:8547724

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

Ifnb1

interferon beta 1

susceptibility
no_association

ISO
IDA

DNA:SNP,haplotype: rs9333358(human)

RGD

RGD:401851921, RGD:401854228

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

Il10

interleukin 10

treatment

RGD

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

Il18

interleukin 18

treatment

RGD

PMID:20584315

RGD:8655991

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

interleukin 1 beta

treatment

RGD

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

interleukin 6

treatment

RGD

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Irf8

interferon regulatory factor 8

exacerbates

RGD

PMID:24528256

RGD:329902074

NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829

Itga9

integrin subunit alpha 9

susceptibility

DNA:SNPs,haplotype:rs189897,rs2212020(human)

RGD

PMID:21764681

RGD:13602007

NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754

Itgam

integrin subunit alpha M

protein:increased expression:neutrophil (human)

RGD

PMID:31355307

RGD:329901831

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

Kalrn

kalirin, RhoGEF kinase

susceptibility
sexual_dimorphism

PMID:25917671 PMID:28706949

DNA:SNP:intron: (rs6438833) (human)
DNA:SNPs, haplotypes:intron,cds: (rs7620580, rs1708303) (human)

RGD

RGD:11085239, RGD:329956420

NCBI chr11:66,198,155...66,803,166
Ensembl chr11:66,198,173...66,797,610

Kcnn4

potassium calcium-activated channel subfamily N member 4

ameliorates

RGD

PMID:29037241

RGD:329969881

NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340

Lipg

lipase G, endothelial type

susceptibility

DNA:polymorphism: :584C>T (human)

RGD

PMID:17016617

RGD:1601237

NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260

lymphotoxin alpha

RGD

NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859

Map2

microtubule-associated protein 2

RGD

PMID:22444278

RGD:6483079

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

Map3k5

mitogen-activated protein kinase kinase kinase 5

treatment

RGD

PMID:23968852

RGD:10412642

NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800

Mir145

microRNA 145

ameliorates

PMID:22370881 PMID:26722607

miRNA:increased expression:blood (human)

RGD

RGD:155260291, RGD:155260295

NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727

Mir21

microRNA 21

RNA:increased expression:brain

RGD

PMID:20840605

RGD:41410884

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

Mir210

microRNA 210

severity
treatment

PMID:21622133 PMID:29111308 PMID:34708885

miRNA:decreased expression:blood (human)
miRNA:decreased expression:blood serum (human)

RGD

RGD:155260318, RGD:155260331, RGD:155260326

NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454

microRNA 223

treatment

RGD

PMID:28469772

RGD:35668865

NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996

Mir30a

microRNA 30a

treatment

RGD

PMID:28469772

RGD:35668865

NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670

Mir383

microRNA 383

treatment

RGD

PMID:28469772

RGD:35668865

NCBI chr16:54,040,340...54,040,413
Ensembl chr16:54,040,340...54,040,413

Mir494

microRNA 494

disease_progression

RGD

PMID:32239566

RGD:155883173

NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793

Mmp2

matrix metallopeptidase 2

CTD Direct Evidence: marker/mechanism

PMID:16846501

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

matrix metallopeptidase 9

CTD Direct Evidence: marker/mechanism

PMID:16846501

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

Mt-co2

mitochondrially encoded cytochrome c oxidase II

ClinVar Annotator: match by term: Ischemic stroke

Mt-cyb

mitochondrially encoded cytochrome b

ClinVar Annotator: match by term: Ischemic stroke

NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278

Mthfr

methylenetetrahydrofolate reductase

DNA:transition:cds:g.677C>T (human)

RGD

PMID:10929044

RGD:1580590

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

Mtr

5-methyltetrahydrofolate-homocysteine methyltransferase

susceptibility

DNA:SNPs,haplotypes:multiple

RGD

NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822

Myrf

myelin regulatory factor

DNA:SNP:exon:rs174535(human)

RGD

PMID:36193932

RGD:213230151

NCBI chr 1:206,854,175...206,886,276
Ensembl chr 1:206,854,175...206,886,157

Ndufa13

NADH:ubiquinone oxidoreductase subunit A13

protein:increased expression:brain, neuron, astrocyte:

RGD

PMID:17523870

RGD:401854233

NCBI chr16:19,526,633...19,533,567
Ensembl chr16:19,526,565...19,535,726

nitric oxide synthase 3

ClinVar Annotator: match by term: Ischemic stroke

PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 More...

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

Notch3

notch receptor 3

ClinVar Annotator: match by term: Ischemic stroke

PMID:9388399 PMID:10371548 PMID:10802804 PMID:10854111 PMID:11102981 More...

NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025

Npy

neuropeptide Y

PMID:11821007 PMID:17123484

protein:increased expression:cerebral cortex
CTD Direct Evidence: marker/mechanism

CTD
RGD

RGD:10448931

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

Nr1h3

nuclear receptor subfamily 1, group H, member 3

susceptibility

DNA:SNPs, haplotype:promoter:c.-115G>A, c.-840C>A (rs12221497, rs61896015) (human)

RGD

PMID:21903943

RGD:401842365

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

Park7

Parkinsonism associated deglycase

treatment

PMID:18003894 PMID:18003894

RGD

RGD:13462069, RGD:13462069

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

Pdx1

pancreatic and duodenal homeobox 1

associated with Metabolic Syndrome; DNA:duplication:5' utr:-108 3G>4G (human)

RGD

PMID:18506375

RGD:2311309

NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064

Phactr1

phosphatase and actin regulator 1

DNA:SNP:intron: (rs12526453) (human)

RGD

PMID:23042660

RGD:401900685

NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831

Pla2g7

phospholipase A2 group VII

RGD

PMID:18201705

RGD:6482775

NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476

plasminogen activator, tissue type

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:1579960 PMID:1899364 PMID:9183334 PMID:16148626 PMID:18195371 More...

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

plasminogen activator, urokinase

CTD Direct Evidence: therapeutic

PMID:12133459 PMID:16773802

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

Plaur

plasminogen activator, urokinase receptor

RGD

PMID:20138161

RGD:6483804

NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595

Pon1

paraoxonase 1

susceptibility

DNA:missense mutation:cds:p.Q192R (human)

RGD

PMID:10729395

RGD:1580196

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

Pon2

paraoxonase 2

susceptibility

DNA:SNPs,haplotypes: (rs11545941, rs6954345) (human)

RGD

NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248

Prkch

protein kinase C, eta

susceptibility

PMID:12958323 PMID:17206144 PMID:25741868

ClinVar Annotator: match by term: Cerebral infarction, susceptibility to | ClinVar Annotator: match by term: Ischemic stroke

ClinVar
OMIM

NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654

Proc

protein C, inactivator of coagulation factors Va and VIIIa

CTD Direct Evidence: marker/mechanism

PMID:33761690

NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133

Pros1

protein S

DNA:missense mutation:exon:p.R355C (1063C>T) (human)

RGD

PMID:21172841

RGD:11250416

NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286

Ptgis

prostaglandin I2 synthase

exacerbates
treatment

PMID:28478978 PMID:28108096 PMID:11130769 PMID:11997284

DNA:SNP, haplotype:3' utr: (rs5602) (human)
DNA:SNPs:exon, 3' utr: (rs5629, rs5602) (human)
DNA:repeat:promoter:g.-6(CCGCCAGCC)3-7 (human)

RGD

RGD:401901149, RGD:401959400, RGD:401901269, RGD:401901194

NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451

Rbp4

retinol binding protein 4

exacerbates
severity

PMID:19846170 PMID:30030781 PMID:30038059

protein:increased expression:blood plasma (human)
protein:increased expression:blood serum (human)
associated with diabetes mellitus; protein:increased expression:blood serum (human)

RGD

RGD:329845582, RGD:329853305, RGD:329845588

NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399

RT1-CE16

RT1 class I, locus CE16

susceptibility

DNA:polymorphism::HLA-A31:01 (human)

RGD

PMID:24767290

RGD:401827096

NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563

RT1-Db1

RT1 class II, locus Db1

susceptibility

DNA:polymorphism,haplotype::HLA-B37:01 (human)

RGD

PMID:24767290

RGD:401827096

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

serpin family E member 1

treatment

RGD

PMID:25702149

RGD:11075081

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

Serping1

serpin family G member 1

treatment

associated with Venous Thrombosis

RGD

PMID:10446335

RGD:8661653

NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034

Slc6a1

solute carrier family 6 member 1

mRNA:increased expression:cerebral cortex, neuron

RGD

PMID:15349978

RGD:1643205

NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293

Sos1

SOS Ras/Rac guanine nucleotide exchange factor 1

mRNA:increased expression:blood (human)

RGD

PMID:35041140

RGD:155598600

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

Tbxas1

thromboxane A synthase 1

susceptibility

DNA:polymorphisms: :

RGD

PMID:19403042

RGD:11059536

NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096

Thbd

thrombomodulin

susceptibility

DNA:missense mutation:cds:p.A455V (human)

RGD

PMID:15574195

RGD:5685021

NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193

tumor necrosis factor

treatment

PMID:16173529 PMID:29111308

RGD

RGD:1580315, RGD:155260331

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tnfrsf11b

TNF receptor superfamily member 11B

disease_progression

RGD

PMID:19895657

RGD:7205492

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

Tomm40

translocase of outer mitochondrial membrane 40

DNA:SNP: :rs2075650 (human)

RGD

PMID:26171154

RGD:13464126

NCBI chr 1:79,358,781...79,370,882
Ensembl chr 1:79,358,786...79,370,915

Tyms

thymidylate synthetase

susceptibility

DNA:SNPs,haplotypes: (rs502396,rs16430,rs8423)

RGD

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

vimentin

RGD

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

Chronic Allograft Dysfunction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

advanced glycosylation end product-specific receptor

treatment

PMID:22217518 PMID:23769041

RGD

RGD:7245568, RGD:8695995

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

complement C3

treatment

RGD

PMID:25122638

RGD:11040803

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

Cd40

CD40 molecule

treatment

RGD

PMID:22826618

RGD:11352297

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

Cd40lg

CD40 ligand

treatment

liver

RGD

PMID:22826618

RGD:11352297

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

coagulation factor VII

treatment

human protein in a rat model

RGD

PMID:12095034

RGD:11049508

NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610

Hmgb1

high mobility group box 1

treatment

RGD

PMID:22217518

RGD:7245568

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

Kcnn4

potassium calcium-activated channel subfamily N member 4

ameliorates

RGD

PMID:24312257

RGD:401700379

NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340

Mtor

mechanistic target of rapamycin kinase

treatment

RGD

PMID:23985719

RGD:10041002

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

tumor necrosis factor

treatment

RGD

PMID:24598936

RGD:10450586

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Chronic Allograft Nephropathy

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

aconitase 1

RGD

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

Alb

albumin

disease_progression

RGD

PMID:24370342

RGD:11035281

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

Ccl3

C-C motif chemokine ligand 3

RGD

PMID:17298994

RGD:7241819

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

Ccn2

cellular communication network factor 2

disease_progression

mRNA, protein:increased expression:kidney (rat)

RGD

PMID:19921985

RGD:150517553

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

Clu

clusterin

treatment

RGD

PMID:22494435

RGD:9068431

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

citrate synthase

treatment

RGD

PMID:20005400

RGD:243048470

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

Mmp3

matrix metallopeptidase 3

RGD

PMID:22845765

RGD:7241226

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

Mmp7

matrix metallopeptidase 7

treatment

RGD

PMID:18209025

RGD:9685339

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

Pdgfa

platelet derived growth factor subunit A

RGD

PMID:11889420

RGD:11080974

NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497

Pdgfb

platelet derived growth factor subunit B

PMID:15785371 PMID:11889420

mRNA:increased expression:kidney:

RGD

RGD:10449491, RGD:11080974

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

Pdgfra

platelet derived growth factor receptor alpha

RGD

PMID:11889420

RGD:11080974

NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335

Pdgfrb

platelet derived growth factor receptor beta

RGD

PMID:11889420

RGD:11080974

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

plasminogen activator, urokinase

protein:increased secretion:T lymphocyte (human)

RGD

PMID:16387096

RGD:7241259

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

Pparg

peroxisome proliferator-activated receptor gamma

protein:increased expression:kidney:

RGD

PMID:16221712

RGD:13208600

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

serpin family E member 1

treatment

PMID:16221712 PMID:18192922

protein:increased expression:kidney:

RGD

RGD:13208600, RGD:13208601

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

Chronic Cerebral Hypoperfusion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Aco1

aconitase 1

protein:decreased expression:hippocampus

RGD

PMID:22639386

RGD:11541085

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

Apoe

apolipoprotein E

protein:increased expression:cerebral cortex, synapse

RGD

PMID:28620701

RGD:13703133

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

App

amyloid beta precursor protein

protein:increased expression:cerebral white matter:

RGD

PMID:11743996

RGD:10054250

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

Bace1

beta-secretase 1

protein:increased expression:hippocampus

RGD

PMID:28683457

RGD:13782142

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

Bnip3l

BCL2 interacting protein 3 like

mRNA:increased expression:hippocampus

RGD

PMID:24072673

RGD:10402542

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

dystroglycan 1

RGD

NCBI chr 8:108,890,926...108,955,611
Ensembl chr 8:108,890,929...108,952,325

Fth1

ferritin heavy chain 1

protein:increased expression:hippocampus

RGD

PMID:22639386

RGD:11541085

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

Gstp1

glutathione S-transferase pi 1

treatment

RGD

PMID:16645134

RGD:10401930

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

Hcn1

hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

RGD

PMID:24838625

RGD:9686415

NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774

Hcn2

hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2

RGD

PMID:24838625

RGD:9686415

NCBI chr 7:9,969,801...9,988,839
Ensembl chr 7:9,970,368...9,988,841

hypoxia inducible factor 1 subunit alpha

protein:increased expression:hippocampus

RGD

PMID:24072673

RGD:10402542

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

Map3k5

mitogen-activated protein kinase kinase kinase 5

protein:hyperphosphorylation:brain:

RGD

PMID:24371084

RGD:10412307

NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800

Mapk14

mitogen activated protein kinase 14

protein:hyperphosphorylation:corpus callosum, endothelial cell, astrocyte:

RGD

PMID:24371084

RGD:10412307

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

Mcm2

minichromosome maintenance complex component 2

protein:increased expression:dentate gyrus

RGD

PMID:17931356

RGD:10412049

NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847

nitric oxide synthase 3

RGD

PMID:15703700

RGD:13824977

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

Nox1

NADPH oxidase 1

ameliorates

RGD

PMID:24294978

RGD:329955573

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

Tfrc

transferrin receptor

protein:increased expression:hippocampus

RGD

PMID:22639386

RGD:11541085

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

Chronic Lung Allograft Dysfunction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Epas1

endothelial PAS domain protein 1

mRNA:increased expression:lung

RGD

PMID:22305384

RGD:10395369

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

compartment syndrome

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Hpx

hemopexin

CTD Direct Evidence: therapeutic

PMID:14500188

NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328

coronary aneurysm

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Adipoq

adiponectin, C1Q and collagen domain containing

associated with Mucocutaneous Lymph Node Syndrome;protein:increased expression:serum

RGD

PMID:22683371

RGD:8694456

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

Gja1

gap junction protein, alpha 1

CTD Direct Evidence: marker/mechanism

PMID:15548583

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

Itpkc

inositol-trisphosphate 3-kinase C

CTD Direct Evidence: marker/mechanism

PMID:18084290

NCBI chr 1:82,500,957...82,522,533
Ensembl chr 1:82,500,957...82,522,779

Mill1

MHC I like leukocyte 1

CTD Direct Evidence: marker/mechanism

PMID:10899738

NCBI chr 1:78,372,798...78,398,932
Ensembl chr 1:78,372,802...78,398,930

Mmp12

matrix metallopeptidase 12

susceptibility

RGD

PMID:12103254

RGD:1582363

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

coronary artery disease

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Abca1

ATP binding cassette subfamily A member 1

PMID:11086027 PMID:15118671

RGD
GAD

RGD:1600951, RGD:1331525

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

Abcc6

ATP binding cassette subfamily C member 6

DNA:nonsense mutation:exon:p.R1141X (3421C>T) (human)

RGD

PMID:12176944

RGD:11038788

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

Abcg5

ATP binding cassette subfamily G member 5

CTD Direct Evidence: marker/mechanism