squamous cell neoplasm - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	squamous cell neoplasm	go back to main search page
Accession:	DOID:3168	browse the term
Definition:	A cell type benign neoplasm composed_of epithelial cells located_in the ectodermal or endodermal cells linking body cavities. (DO)
Synonyms:	exact_synonym:	epidermoid cell tumor; squamous cell neoplasms; squamous cell tumor
	primary_id:	MESH:D018307
	xref:	NCI:C3792
For additional species annotation, visit the Alliance of Genome Resources.

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Rat (717) Mouse (684) Human (4907) Chinchilla (598) Bonobo (641) Dog (663) Squirrel (599) Pig (648) Green Monkey (632) Naked Mole-rat (586) All
Genes (671) Strains (2) Cell Lines (44)

squamous cell neoplasm

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BRCA2, DNA repair associated

CTD Direct Evidence: marker/mechanism

NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567

G

checkpoint kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

serine/threonine kinase receptor associated protein

RGD

NCBI chr 4:170,646,042...170,660,291
Ensembl chr 4:170,646,001...170,660,828

G

tumor protein p63

CTD Direct Evidence: marker/mechanism

NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398

adenoid squamous cell carcinoma

term browser

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Object Name

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Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

HNF1 homeobox A

RGD

NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104

adenosquamous gallbladder carcinoma

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

discoidin domain receptor tyrosine kinase 2

disease_progression

RGD

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

interferon induced transmembrane protein 1

disease_progression

RGD

NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169

adenosquamous lung carcinoma

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

transthyretin

protein:increased expression:lung (human)

NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008

anogenital venereal wart

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 20

protein:decreased expression:skin

RGD

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

CD8 subunit alpha

mRNA:decreased expression:zone of skin (human)

NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040

G

cytotoxic T-lymphocyte-associated protein 4

mRNA,protein:increased expression:multiple (human)

RGD

NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963

G

forkhead box P3

mRNA,protein:increased expression:multiple (human)

RGD

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

interferon, alpha 1

treatment

RGD

NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925

G

interleukin 10

mRNA,protein:increased expression:multiple (human)

RGD

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12B

treatment

protein:decreased expression:peripheral blood mononuclear cells (human)

RGD

PMID:16114559 PMID:23754510

RGD:7829774, RGD:40400714

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 2

protein:decreased expression:peripheral blood mononuclear cells (human)

RGD

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 21

protein:decreased expression:blood serum (human)

RGD

NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996

G

interleukin 4

treatment

protein:increased expression:peripheral blood mononuclear cells (human)

RGD

PMID:16114559 PMID:23754510

RGD:7829774, RGD:40400714

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

protein:decreased expression:peripheral blood mononuclear cells (human)

RGD

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

killer cell lectin like receptor K1

mRNA,protein:decreased expression:multiple (human)

RGD

NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459

G

mitogen-activated protein kinase 8

treatment

mRNA:increased expression:zone of skin (human)

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

MYD88, innate immune signal transduction adaptor

mRNA,protein:increased expression:multiple (human)

RGD

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

natural cytotoxicity triggering receptor 1

mRNA,protein:decreased expression:multiple (human)

RGD

NCBI chr 1:69,614,744...69,622,594
Ensembl chr 1:69,616,601...69,660,558

G

programmed cell death 1

mRNA,protein:increased expression:multiple (human)

RGD

NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937

G

protein tyrosine phosphatase, non-receptor type 11

protein:increased expression:foreskin

RGD

NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925

G

protein tyrosine phosphatase, non-receptor type 6

protein:increased expression:foreskin

RGD

NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984

G

serpin family F member 1

disease_progression

mRNA, protein:decreased expression:skin of body (human)

RGD

NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646

G

transforming growth factor, beta 1

mRNA,protein:increased expression:multiple (human)

RGD

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

toll-like receptor 2

mRNA,protein:increased expression:multiple (human)

RGD

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 3

mRNA,protein:increased expression:multiple (human)

RGD

NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545

G

toll-like receptor 4

mRNA,protein:increased expression:multiple (human)

RGD

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

toll-like receptor 7

mRNA,protein:increased expression:multiple (human)

RGD

NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754

G

toll-like receptor 8

mRNA,protein:increased expression:multiple (human)

RGD

NCBI chr X:27,091,780...27,116,092
Ensembl chr X:27,091,778...27,116,549

G

toll-like receptor 9

mRNA,protein:increased expression:multiple (human)

RGD

NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796

G

tumor necrosis factor

protein:increased expression:peripheral blood mononuclear cells (human)

RGD

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 18

mRNA,protein:increased expression:multiple (human)

RGD

NCBI chr 5:166,618,461...166,622,353
Ensembl chr 5:166,618,969...166,622,353

basaloid squamous cell carcinoma

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PubMed Reference(s)

RGD Reference(s)

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G

patched 1

DNA:missense mutations, nonsense mutations

RGD

NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333

bladder squamous cell carcinoma

term browser

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RGD Reference(s)

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G

phosphatase and tensin homolog

disease_progression

associated with schistosomiasis;protein:decreased expression:urothelium (human)

RGD

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

Bowen's Disease

term browser

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Object Name

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Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin D1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

associated with Vulvar Neoplasms;mRNA:increased expression:vulva

RGD

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin-dependent kinase inhibitor 1A

protein:increased expression:skin:

RGD

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

nuclear respiratory factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

PPARG coactivator 1 alpha

CTD Direct Evidence: marker/mechanism

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

transcription factor A, mitochondrial

CTD Direct Evidence: marker/mechanism

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

bowenoid papulosis

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

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G

baculoviral IAP repeat-containing 2

mRNA:increased expression:perianal skin (human)

RGD

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

mRNA:increased expression:perianal skin (human)

RGD

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, and Keratoderma

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

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G

SAM and SH3 domain containing 1

ClinVar Annotator: match by term: Cancer, alopecia, pigment dyscrasia, onychodystrophy, and keratoderma | ClinVar Annotator: match by term: SASH1-related condition

PMID:25315659 PMID:25741868 PMID:28492532

NCBI chr 1:3,119,915...3,418,536
Ensembl chr 1:3,121,332...3,439,870

cervical squamous cell carcinoma

term browser

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Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine deaminase, RNA-specific

disease_progression

protein:increased expression:cervix squamous epithelium (human)

RGD

NCBI chr 2:175,138,391...175,178,280
Ensembl chr 2:175,138,403...175,178,282

G

BCL2 associated X, apoptosis regulator

protein:increased expression:uterine cervix

RGD

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

baculoviral IAP repeat-containing 2

disease_progression

DNA, protein:amplification, increased expression:uterine cervix, nucleus

RGD

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

BRCA1 interacting DNA helicase 1

severity

mRNA, protein:increased expression:uterine cervix, nucleus (human)

RGD

NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324

G

C-C motif chemokine ligand 22

severity

RGD

NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400

G

C-C motif chemokine receptor 4

severity

RGD

NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056

G

Cd82 molecule

protein:decreased expression:uterine cervix

RGD

NCBI chr 3:79,387,361...79,431,847
Ensembl chr 3:79,385,887...79,431,809

G

colony stimulating factor 1 receptor

protein:increased expression:uterine cervix

RGD

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

fibroblast growth factor 7

cervical squamous cell carcinoma

RGD

NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929

G

fibroblast growth factor receptor 3

no_association

DNA:missense mutation:cds: p.S249G (human)

RGD

NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341

G

Fos proto-oncogene, AP-1 transcription factor subunit

disease_progression

protein:increased expression:uterine cervix

RGD

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 1, AP-1 transcription factor subunit

protein:decreased expression:uterine cervix

RGD

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box P3

severity

RGD

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

microRNA 21

RNA:increased expression:cervical cell

RGD

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 31

RNA:increased expression:blood serum (human)

RGD

NCBI chr 5:103,599,038...103,599,143

G

podoplanin

disease_progression

RGD

NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656

G

SMAD family member 3

severity

RGD

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

TIMP metallopeptidase inhibitor 2

protein:decreased expression:uterine cervix

RGD

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

transmembrane BAX inhibitor motif containing 6

disease_progression

mRNA:increased expression:uterine cervix

RGD

NCBI chr 7:130,527,313...130,542,567
Ensembl chr 7:130,527,316...130,543,633

G

TNF receptor superfamily member 4

severity

RGD

NCBI chr 5:166,606,909...166,609,599
Ensembl chr 5:166,606,909...166,609,599

G

TNF superfamily member 4

severity

RGD

NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788

G

tumor protein p53

disease_progression

RGD

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

thymidine phosphorylase

disease_progression

RGD

NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874

choroid plexus papilloma

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tumor protein p53

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Choroid plexus papilloma | ClinVar Annotator: match by term: Papilloma of choroid plexus

CTD
ClinVar
OMIM

PMID:1565143 PMID:1565144 PMID:1591732 PMID:1631137 PMID:1683921 More...

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

conjunctival squamous cell carcinoma

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ADAM metallopeptidase domain 3A

DNA, mRNA:amplification, increase expression

RGD

NCBI chr16:67,299,949...67,349,970
Ensembl chr16:67,299,949...67,349,968

epidermodysplasia verruciformis

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

transmembrane channel like 6

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Epidermodysplasia verruciformis

PMID:9536098 PMID:12426567 PMID:15042430 PMID:16199547 PMID:17139267 More...

NCBI chr10:102,982,059...102,999,509
Ensembl chr10:102,971,229...102,998,960

G

transmembrane channel-like 8

ClinVar Annotator: match by term: Epidermodysplasia verruciformis

PMID:9536098 PMID:10084299 PMID:12426567 PMID:16045695 PMID:16199547 More...

NCBI chr10:103,000,038...103,010,601
Ensembl chr10:102,998,402...103,010,590

G

trinucleotide repeat containing adaptor 6C

ClinVar Annotator: match by term: Epidermodysplasia verruciformis

NCBI chr10:102,908,958...102,979,543
Ensembl chr10:102,868,828...102,978,194

Epidermodysplasia Verruciformis 1

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

transmembrane channel like 6

susceptibility

ClinVar Annotator: match by term: Epidermodysplasia verruciformis, susceptibility to, 1 | ClinVar Annotator: match by term: TMC6-related condition

PMID:9536098 PMID:12426567 PMID:15042430 PMID:16199547 PMID:17139267 More...

NCBI chr10:102,982,059...102,999,509
Ensembl chr10:102,971,229...102,998,960

G

transmembrane channel-like 8

ClinVar Annotator: match by term: Epidermodysplasia verruciformis, susceptibility to, 1

PMID:9536098 PMID:12426567 PMID:17576681 PMID:22158547 PMID:25741868 More...

NCBI chr10:103,000,038...103,010,601
Ensembl chr10:102,998,402...103,010,590

Epidermodysplasia Verruciformis 2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

transmembrane channel like 6

ClinVar Annotator: match by term: Epidermodysplasia verruciformis, susceptibility to, 2 | ClinVar Annotator: match by term: TMC8-related condition

PMID:9536098 PMID:17576681 PMID:24033266 PMID:25741868 PMID:28492532

NCBI chr10:102,982,059...102,999,509
Ensembl chr10:102,971,229...102,998,960

G

transmembrane channel-like 8

susceptibility

ClinVar Annotator: match by term: Epidermodysplasia verruciformis, susceptibility to, 2 | ClinVar Annotator: match by term: TMC8-related condition

PMID:9536098 PMID:10084299 PMID:12426567 PMID:16199547 PMID:17576681 More...

NCBI chr10:103,000,038...103,010,601
Ensembl chr10:102,998,402...103,010,590

Epidermodysplasia Verruciformis 3

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcium and integrin binding 1

susceptibility

ClinVar Annotator: match by term: CIB1-related condition | ClinVar Annotator: match by term: Epidermodysplasia verruciformis, susceptibility to, 3

PMID:228581 PMID:19702156 PMID:20982046 PMID:21196704 PMID:25741868 More...

NCBI chr 1:134,178,331...134,183,895
Ensembl chr 1:134,178,331...134,213,423

Epidermodysplasia Verruciformis 4

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ras homolog family member H

ClinVar Annotator: match by term: Epidermodysplasia verruciformis, susceptibility to, 4 | ClinVar Annotator: match by term: RHOH-related condition

PMID:22850876 PMID:25741868 PMID:28492532 PMID:38775840

NCBI chr14:42,341,135...42,371,971
Ensembl chr14:42,337,751...42,386,369

Epidermodysplasia Verruciformis 5

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 7

ClinVar Annotator: match by term: Epidermodysplasia verruciformis, susceptibility to, 5 | ClinVar Annotator: match by term: IL7-related condition

PMID:25741868 PMID:25981006 PMID:28492532 PMID:31900472 PMID:39352394

NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075

epidermolytic acanthoma

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

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G

keratin 10

ClinVar Annotator: match by term: Epidermolytic acanthoma

PMID:1381287 PMID:7508181 PMID:7509230 PMID:7512983 PMID:21271994 More...

NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701

esophagus squamous cell carcinoma

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

adenylate cyclase activating polypeptide 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773

G

ajuba LIM protein

CTD Direct Evidence: marker/mechanism

NCBI chr15:28,019,775...28,031,537
Ensembl chr15:28,019,778...28,030,021

G

AKT serine/threonine kinase 1

disease_progression

protein:increased expression:esophagus (human)

RGD

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 2 family member

CTD Direct Evidence: marker/mechanism

PMID:16639733 PMID:22960999

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

annexin A1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

ATM serine/threonine kinase

disease_progression

Smoke Inhalation Injury; mRNA:increased expression:esophagus (human)

RGD

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase Na+/K+ transporting subunit beta 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933

G

axin 1

disease_progression

protein:decreased expression:esophagus (human)

RGD

NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615

G

alpha-2-glycoprotein 1, zinc-binding

disease_progression

RGD

NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091

G

antizyme inhibitor 1

RGD

NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578

G

beta-2 microglobulin

CTD Direct Evidence: marker/mechanism

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

biliverdin reductase B

CTD Direct Evidence: marker/mechanism

NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375

G

BMI1 proto-oncogene, polycomb ring finger

RGD

NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690

G

bone morphogenetic protein 6

protein:increased expression:esophagus

RGD

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

BRCA1, DNA repair associated

DNA:SNP: :rs799917 (human)

RGD

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

BRCA2, DNA repair associated

DNA:nonsense mutation: :p.K3326X (human)

RGD

NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567

G

bone marrow stromal cell antigen 2

disease_progression

RGD

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

G

BUB1 mitotic checkpoint serine/threonine kinase B

CTD Direct Evidence: marker/mechanism

NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547

G

calreticulin

ameliorates

CTD Direct Evidence: marker/mechanism
human cells in a mouse model

CTD
RGD

PMID:21517111 PMID:19684620 PMID:23814025

RGD:150521703, RGD:150521679

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

capping actin protein of muscle Z-line subunit alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:192,319,696...192,364,755
Ensembl chr 2:192,319,702...192,364,480

G

carbonic anhydrase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208

G

carbonic anhydrase 12

severity

RGD

NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440

G

carbonic anhydrase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

caspase 8

exacerbates

mRNA,protein:decreased expression:esophagus squamous epithelium (human)

RGD

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

chromobox 8

severity

mRNA:increased expression:esophagus:

RGD

NCBI chr10:104,294,518...104,296,956
Ensembl chr10:104,294,518...104,297,024

G

coiled-coil alpha-helical rod protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:3,205,675...3,218,437
Ensembl chr20:3,205,676...3,218,308

G

cyclin D1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase inhibitor 1A

CTD Direct Evidence: therapeutic

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

CTD Direct Evidence: marker/mechanism

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

cyclin-dependent kinase inhibitor 2B

DNA:SNPs: :rs615552, rs573687 (human)

RGD

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

cofilin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587

G

cholinergic receptor nicotinic alpha 5 subunit

susceptibility

DNA:SNP: :rs667282(human)
mRNA:increased expression:esophagus (human)

RGD

PMID:23844051 PMID:27610024

RGD:150524358, RGD:151361143

NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146

G

cholinergic receptor nicotinic alpha 7 subunit

exacerbates
disease_progression

mRNA:increased expression:esophagus (human)

RGD

PMID:27610024 PMID:33603170 PMID:33603170

RGD:151361143, RGD:151667905, RGD:151667905

NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 4 subunit

mRNA:increased expression:esophagus (human)

RGD

NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027

G

chloride intracellular channel 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712

G

CLPTM1-like

susceptibility
no_association

DNA:SNP: :rs451360(human)
DNA:SNP: :rs401681(human)
mRNA:increased expression:esophagus

RGD

PMID:26716642 PMID:24386361 PMID:25480402 PMID:25007268

RGD:11572962, RGD:150537098, RGD:150530497, RGD:150530488

NCBI chr 1:29,667,545...29,683,530
Ensembl chr 1:29,667,545...29,683,530

G

collagen type XIV alpha 1 chain

disease_progression

DNA:hypermethylation

RGD

NCBI chr 7:86,722,093...86,937,215
Ensembl chr 7:86,722,094...86,937,214

G

cellular retinoic acid binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:55,138,363...55,159,360
Ensembl chr 8:55,151,285...55,159,360

G

CREB binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

colony stimulating factor 1 receptor

mRNA:decreased expression:esophagus squamous epithelium (human)

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

cystatin B

CTD Direct Evidence: marker/mechanism

NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526

G

C-X-C motif chemokine receptor 4

disease_progression

protein:increased expression:esophagus squamous epithelium (human)

RGD

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome P450, family 1, subfamily a, polypeptide 1

RGD

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

protein:increased expression:esophagus (rat)

RGD

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 24, subfamily a, polypeptide 1

susceptibility

DNA:SNP:CDS: (rs2296241) (human)

RGD

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 26, subfamily b, polypeptide 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628

G

DAB2 interacting protein

severity

protein:decreased expression:esophagus (human)

RGD

NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280

G

DCC netrin 1 receptor

DNA:deletions:multiple (human)

OMIM
RGD

NCBI chr18:64,868,987...65,972,783
Ensembl chr18:64,873,898...65,972,740

G

death inducer-obliterator 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:167,772,535...167,825,894
Ensembl chr 3:167,772,770...167,817,218

G

DNA methyltransferase 3 beta

disease_progression

protein:increased expression:nucleus:

RGD

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

dipeptidylpeptidase 4

protein:increased expression: esophagus

RGD

NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901

G

ephrin B2

severity
exacerbates
ameliorates

mRNA:increased expression:esophagus squamous epithelium (human)
mRNA,protein:increased expression:esophagus squamous epithelium (human)
human cells in mouse model

RGD

PMID:17611172 PMID:31885720 PMID:29190834

RGD:153300947, RGD:153300949, RGD:153300948

NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391

G

epidermal growth factor receptor

severity

protein:increased expression:esophagus (human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21947696 PMID:10385363

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

euchromatic histone lysine methyltransferase 1

disease_progression

protein:increased expression:esophagus:
protein:increased expression:esophagus mucosa:

RGD

PMID:24649311 PMID:24805087

RGD:9589143, RGD:9590071

NCBI chr 3:7,580,680...7,729,046
Ensembl chr 3:7,580,683...7,729,007

G

euchromatic histone lysine methyltransferase 2

disease_progression

protein:increased expression:esophagus mucosa:

RGD

NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547

G

E1A binding protein p300

CTD Direct Evidence: marker/mechanism

PMID:17965222 PMID:25151357

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

erythrocyte membrane protein band 4.1-like 3

disease_progression

DNA:hypermethylation

RGD

NCBI chr 9:109,056,178...109,260,607
Ensembl chr 9:109,016,113...109,260,607

G

EPH receptor B4

exacerbates

mRNA,protein:increased expression:esophagus squamous epithelium (human)

RGD

NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314

G

erb-b2 receptor tyrosine kinase 4

susceptibility
disease_progression

DNA:SNPs, haplotypes: :rs1595066 and rs16845990 (human)
protein:altered localization:nucleus

RGD

PMID:24916311 PMID:18000820

RGD:126781764, RGD:126781765

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

ERCC excision repair 1, endonuclease non-catalytic subunit

treatment

RGD

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

disease_progression

RGD

PMID:25613619 PMID:21165554

RGD:126781697, RGD:126781701

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

FA complementation group A

DNA:missense mutation: :p.S858R (human)

RGD

NCBI chr19:51,304,126...51,362,586
Ensembl chr19:51,304,021...51,362,527

G

fibroblast activation protein, alpha

protein:increased expression: esophagus

RGD

NCBI chr 3:47,138,823...47,207,671
Ensembl chr 3:47,138,813...47,225,545

G

fatty acid synthase

CTD Direct Evidence: marker/mechanism

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

FAT atypical cadherin 1

CTD Direct Evidence: marker/mechanism
protein:decreased expression:esophagus squamous epithelium (human)

CTD
RGD

PMID:25151357 PMID:29365412 PMID:24590895

RGD:151347646, RGD:151347630

NCBI chr16:47,177,253...47,296,261
Ensembl chr16:47,177,248...47,296,107

G

FAT atypical cadherin 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:39,364,072...39,456,324
Ensembl chr10:39,364,073...39,456,216

G

FAT atypical cadherin 3

CTD Direct Evidence: marker/mechanism

NCBI chr 8:12,691,470...13,274,336
Ensembl chr 8:12,694,019...13,273,135

G

FAT atypical cadherin 4

CTD Direct Evidence: marker/mechanism

NCBI chr 2:121,927,266...122,056,700
Ensembl chr 2:121,927,942...122,056,707

G

F-box and WD repeat domain containing 7

CTD Direct Evidence: marker/mechanism

NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941

G

FES proto-oncogene, tyrosine kinase

exacerbates

DNA:hypermethylation: (human)

RGD

NCBI chr 1:134,337,698...134,346,934
Ensembl chr 1:134,337,698...134,346,934

G

fibroblast growth factor receptor 4

treatment

RGD

NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242

G

FKBP prolyl isomerase 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743

G

forkhead box A1

onset

DNA:SNPs: :rs12894364 C>T, rs2145146 C>A (human)

RGD

PMID:27050876 PMID:29788741

RGD:151665743, RGD:151665759

NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188

G

far upstream element binding protein 1

exacerbates

protein:increased expression:esophagus (human)
mRNA:increased expression:esophagus (human)

RGD

PMID:26490982 PMID:32481602

RGD:151361192, RGD:151361197

NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602

G

GDP dissociation inhibitor 2

CTD Direct Evidence: marker/mechanism

NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366

G

glyoxalase 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649

G

glutathione peroxidase 3

disease_progression

DNA:hypermethylation

RGD

PMID:30018730 PMID:25050929

RGD:151665494, RGD:151665741

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

growth factor receptor bound protein 7

exacerbates

protein:increased expression:esophagus (human)

RGD

NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052

G

glutathione S-transferase mu 1

no_association

RGD

PMID:11860825 PMID:17916905 PMID:25432134

RGD:14700943, RGD:14700982, RGD:14700948

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase omega 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468

G

glutathione S-transferase pi 1

DNA:polymorphism: :p.I105V (human)

RGD

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17173682 PMID:25432134 PMID:17916905

RGD:14700948, RGD:14700982

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

H19 imprinted maternally expressed transcript

CTD Direct Evidence: marker/mechanism

NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134

G

hypoxia inducible factor 1 subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

high mobility group box 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

high mobility group nucleosome binding domain 5

CTD Direct Evidence: marker/mechanism

NCBI chr X:74,085,871...74,094,488
Ensembl chr X:74,085,875...74,094,441
Ensembl chr 1:74,085,875...74,094,441

G

homeo box B7

severity

protein:increased expression:esophageal mucosa (human)

RGD

NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034

G

heat shock protein family A (Hsp70) member 5

CTD Direct Evidence: marker/mechanism

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

HtrA serine peptidase 1

exacerbates
ameliorates

mRNA,protein:decreased expression:epithelium of esophagus (human)
human gene and cells in mouse model

RGD

PMID:23079781 PMID:23079781

RGD:152975633, RGD:152975633

NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379

G

isocitrate dehydrogenase (NADP(+)) 2

severity

human cells in mouse model

RGD

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

Janus kinase 2

severity

protein:increased phosphorylation:esophagus squamous epithelium (human)

RGD

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

JunB proto-oncogene, AP-1 transcription factor subunit

exacerbates

protein:increased expression:esophagus (human)

RGD

PMID:30227324 PMID:19758438

RGD:151347669, RGD:151347672

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

lysine acetyltransferase 2B

mRNA:decreased expression:esophagus (human)

RGD

NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064

G

lysine demethylase 4C

severity
susceptibility

protein:increased expression:esophageal epithelium, nucleus (human)
DNA:snp:intron:IVS8-3292G>A (rs1340513) (human)

RGD

PMID:24224128 PMID:15805246

RGD:9587746, RGD:9587752

NCBI chr 5:88,100,710...88,306,821
Ensembl chr 5:88,100,733...88,306,818

G

lysine demethylase 5B

severity

protein:increased expression:esophageal mucosa, cytoplasm (human)

RGD

NCBI chr13:46,001,589...46,073,868
Ensembl chr13:46,002,542...46,073,872

G

lysine demethylase 6A

ameliorates

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:esophagus (human)
protein:increased expression:esophagus (human)

CTD
RGD

PMID:25151357 PMID:31804468 PMID:29351209

RGD:150429742, RGD:150429739

NCBI chr X:4,337,466...4,477,100
Ensembl chr X:4,337,750...4,477,062

G

lysine methyltransferase 2C

DNA:mutations:multiple (human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:25151357 PMID:25151357

NCBI chr 4:9,620,638...9,834,787
Ensembl chr 4:9,609,627...9,833,539

G

lysine methyltransferase 2D

DNA:mutations:multiple (human)
mRNA:increased expression:esophagus
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:25151357 PMID:25151357 PMID:29532228

RGD:9588233, RGD:150521712

NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325

G

keratin 13

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,051,887...85,056,099
Ensembl chr10:85,051,889...85,056,084

G

keratin 14

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799

G

keratin 16

RGD

NCBI chr10:85,168,357...85,171,816
Ensembl chr10:85,066,802...85,171,799

G

keratin 17

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392

G

keratin 19

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799

G

keratin 7

disease_progression

RGD

NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052

G

lysyl oxidase-like 2

CTD Direct Evidence: marker/mechanism

NCBI chr15:44,683,449...44,773,067
Ensembl chr15:44,683,880...44,773,067

G

lymphotoxin alpha

CTD Direct Evidence: marker/mechanism

NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859

G

leucine zipper tumor suppressor 1

ClinVar Annotator: match by term: Esophageal squamous cell carcinoma, somatic | ClinVar Annotator: match by term: LZTS1-related condition

PMID:10097140 PMID:25741868 PMID:26504261 PMID:28492532

NCBI chr16:20,542,756...20,598,204
Ensembl chr16:20,542,809...20,598,203

G

mitotic arrest deficient 2 like 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470

G

mitogen-activated protein kinase kinase kinase 1

sexual_dimorphism

DNA:missense mutation, SNP:CDS, exon 14, 3'-UTR: (rs702689,rs702688) (human)

RGD

NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463

G

methyl-CpG binding domain 4 DNA glycosylase

susceptibility

DNA:snp:cds:p.E346K (rs140693) (human)
DNA:snp:intron:IVS5-140A>G (rs3138355) (human)

RGD

PMID:15205355 PMID:25162968

RGD:9588976, RGD:9588980

NCBI chr 4:148,893,049...148,904,833
Ensembl chr 4:148,894,280...148,904,982

G

O-6-methylguanine-DNA methyltransferase

disease_progression

CTD Direct Evidence: marker/mechanism
DNA, protein:hypermethylation, decreased expression:promoter, esophagus

CTD
RGD

PMID:25520135 PMID:21674174

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

microRNA 10a

miRNA:increased expression:esophagus squamous epithelium (human)

RGD

NCBI chr10:81,283,171...81,283,280
Ensembl chr10:81,283,171...81,283,280

G

microRNA 127

RNA:decreased expression:esophagus (human)

RGD

NCBI chr 6:128,546,215...128,546,311
Ensembl chr 6:128,546,215...128,546,311

G

microRNA 193a

exacerbates

miRNA:decreased expression:esophagus (human)

RGD

NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454

G

microRNA 217

CTD Direct Evidence: marker/mechanism

NCBI chr14:102,531,505...102,531,609
Ensembl chr14:102,531,505...102,531,609

G

microRNA 31

ameliorates

RGD

PMID:32123074 PMID:21658006

RGD:127285381, RGD:152998938

NCBI chr 5:103,599,038...103,599,143

G

microRNA 423

CTD Direct Evidence: marker/mechanism

NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226

G

microRNA 494

mRNA:decreased expression:esophagus

RGD

NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793

G

mutL homolog 1

disease_progression

DNA, protein:hypermethylation, decreased expression:promoter, esophagus

RGD

NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617

G

matrix metallopeptidase 14

protein:increased expression: esophagus

RGD

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 2

protein:increased activity: esophagus

RGD

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

protein:increased activity: esophagus

RGD

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mutS homolog 2

disease_progression

DNA, protein:hypermethylation, decreased expression:promoter, esophagus
DNA, protein:hypermethylation, decreased expression:esophagus

RGD

PMID:22265839 PMID:21674174 PMID:24366688

RGD:126790560, RGD:126790574, RGD:126790573

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

metallothionein 1

CTD Direct Evidence: marker/mechanism

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

NFE2 like bZIP transcription factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

notch receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

notch receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088

G

notch receptor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025

G

8-oxoguanine DNA glycosylase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

Paxip1-associated glutamate-rich protein 1

mRNA, protein:decreased expression:esophagus (human)

RGD

NCBI chr 1:181,622,698...181,625,024

G

PBX homeobox 3

RNA:increased expression:esophagus squamous epithelium (human)

RGD

NCBI chr 3:17,488,691...17,682,412
Ensembl chr 3:17,488,693...17,682,791

G

profilin 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631

G

phospholipase C, epsilon 1

CTD Direct Evidence: marker/mechanism

PMID:20729852 PMID:20729853

NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438

G

peroxiredoxin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

proteasome 20S subunit beta 9

disease_progression

RGD

NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512

G

proteasome activator subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:29,069,012...29,071,888
Ensembl chr15:29,068,729...29,071,890

G

proteasome activator subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr15:29,078,495...29,082,794
Ensembl chr15:29,078,500...29,082,946

G

patched 1

disease_progression

RGD

NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333

G

prostaglandin-endoperoxide synthase 2

CTD Direct Evidence: marker/mechanism

PMID:15756444 PMID:16543248 PMID:18197933

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, receptor type, T

susceptibility

DNA:SNPs:3'utr: (rs2866943 , rs6029959 ) (human)

RGD

NCBI chr 3:150,189,343...151,288,145
Ensembl chr 3:150,194,859...151,288,124

G

RB transcriptional corepressor 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RPTOR independent companion of MTOR, complex 2

disease_progression
severity

human cells in mouse model
protein:increased expression:esophagus (human)

RGD

PMID:30119206 PMID:32642408 PMID:28132115

RGD:152995460, RGD:152995512, RGD:152995470

NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426

G

ring finger protein 6

ClinVar Annotator: match by term: Esophageal squamous cell carcinoma, somatic

NCBI chr12:8,816,797...8,826,870
Ensembl chr12:8,816,833...8,826,847

G

RUNX family transcription factor 1

DNA:SNP: :rs2014300 (human)

RGD

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

RUNX family transcription factor 2

mRNA:increased expression:esophagus mucosa

RGD

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

RUNX family transcription factor 3

disease_progression

mRNA:decreased expression:esophagus mucosa

RGD

NCBI chr 5:147,360,587...147,419,161
Ensembl chr 5:147,360,994...147,419,156

G

spalt-like transcription factor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 3:157,474,067...157,491,055
Ensembl chr 3:157,474,642...157,490,822

G

serpin family B member 3

CTD Direct Evidence: marker/mechanism

NCBI chr13:23,274,120...23,280,660
Ensembl chr13:23,274,484...23,313,682

G

SET domain containing 5

disease_progression

RGD

NCBI chr 4:146,217,172...146,294,896
Ensembl chr 4:146,217,180...146,294,894

G

stratifin

CTD Direct Evidence: marker/mechanism

NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314

G

solute carrier family 16 member 10

protein:increased expression:esophagus

RGD

NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839

G

solute carrier family 1 member 5

disease_progression

protein:increased expression:esophagus

RGD

PMID:33609949 PMID:26936531

RGD:151361149, RGD:11532833

NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 39 member 6

CTD Direct Evidence: therapeutic

NCBI chr18:15,864,874...15,885,417
Ensembl chr18:15,864,875...15,885,417

G

solute carrier family 52 member 3

CTD Direct Evidence: marker/mechanism

NCBI chr 3:140,498,924...140,515,845
Ensembl chr 3:140,509,473...140,514,096

G

solute carrier family 7 member 5

disease_progression

protein:increased expression:esophagus

RGD

PMID:31726270 PMID:26936531 PMID:33609949

RGD:151361144, RGD:11532833, RGD:151361149

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

suppressor of cytokine signaling 1

severity
treatment

mRNA:decreased expression:esophagus

RGD

PMID:21385099 PMID:31728180 PMID:28233302

RGD:150573691, RGD:150573815, RGD:150573812

NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383

G

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

PMID:18167182 PMID:21517111

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

SRY-box transcription factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

spen family transcriptional repressor

associated with Neoplasm Metastasis; DNA:mutations

RGD

NCBI chr 5:153,775,287...153,848,677
Ensembl chr 5:153,776,234...153,848,811

G

stromal interaction molecule 1

exacerbates

protein:increased expression:esophagus (human)

NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363

G

stimulator of interferon response cGAMP interactor 1

CTD Direct Evidence: marker/mechanism

NCBI chr18:27,332,119...27,338,371
Ensembl chr18:27,332,119...27,338,335

G

sulfotransferase family 1A member 1

DNA:SNP:exon:p.R213H, 638G>A (human)

RGD

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

transgelin

CTD Direct Evidence: marker/mechanism

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

transporter 1, ATP binding cassette subfamily B member

protein:decreased expression:esophagus

RGD

NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901

G

transporter 2, ATP binding cassette subfamily B member

protein:decreased expression:esophagus

RGD

NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407

G

transcobalamin 2

CTD Direct Evidence: marker/mechanism

NCBI chr14:78,813,343...78,828,549
Ensembl chr14:78,813,343...78,828,489

G

telomerase reverse transcriptase

susceptibility
no_association

DNA:SNPs: : rs2853691,rs2736100(human)
mRNA:increased expression:esophagus squamous epithelium:
DNA:SNP: :rs2736098(human)

RGD

PMID:26716642 PMID:15112252 PMID:25007268

RGD:11572962, RGD:152977757, RGD:150530488

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

tet methylcytosine dioxygenase 2

severity

mRNA:decreased expression:esophagus squamous epithelium (human)
associated with Lymphatic Metastasis;mRNA:decreased expression:esophagus squamous epithelium (human)
DNA:mutations

RGD

PMID:26093090 PMID:27050164 PMID:26873401

RGD:11528815, RGD:150429668, RGD:150429656

NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534

G

tet methylcytosine dioxygenase 3

mRNA:decreased expression:esophagus squamous epithelium (human)

RGD

NCBI chr 4:115,867,412...115,964,433
Ensembl chr 4:115,871,265...115,964,193

G

transforming growth factor, beta receptor 2

NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228

G

TNF alpha induced protein 3

severity

mRNA,protein:increased expression:esophagus squamous epithelium (human)

RGD

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

TNF alpha induced protein 8

CTD Direct Evidence: marker/mechanism

NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517

G

tenascin XB

CTD Direct Evidence: marker/mechanism

G

tumor protein p53

DNA:misssense mutation: :p.R72P (rs1042522) (human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16543248 PMID:25151357 PMID:28789369

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

triosephosphate isomerase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

tropomyosin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802

G

tropomyosin 2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992

G

thioredoxin domain containing 17

CTD Direct Evidence: marker/mechanism

NCBI chr10:56,832,749...56,835,721

G

thymidine phosphorylase

CTD Direct Evidence: marker/mechanism

NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874

G

ubiquitin specific peptidase 8

CTD Direct Evidence: marker/mechanism

NCBI chr 3:113,962,136...114,009,683
Ensembl chr 3:113,962,164...114,009,666

G

ubiquitously transcribed tetratricopeptide repeat containing, Y-linked

DNA:mutations:multiple (human)

RGD

NCBI chr Y:942,838...1,105,313
Ensembl chr Y:924,168...1,103,422

G

VENT homeobox

CTD Direct Evidence: marker/mechanism

NCBI chr X:86,483,893...86,484,900
Ensembl chr X:86,483,893...86,484,954

G

WD repeat containing, antisense to TP53

disease_progression

RGD

NCBI chr10:54,282,092...54,299,908
Ensembl chr10:54,282,105...54,298,929

G

WW domain-containing oxidoreductase

esophageal squamous cell carcinoma, OMIM:133239
ClinVar Annotator: match by term: Esophageal squamous cell carcinoma | ClinVar Annotator: match by term: Esophageal squamous cell carcinoma, somatic
CTD Direct Evidence: marker/mechanism

ClinVar
OMIM
CTD
RGD

PMID:11956080 PMID:16199547 PMID:24456803 PMID:25411445 PMID:25526675 More...

NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391

G

exportin 1

exacerbates

mRNA, protein:increased expression:epithelium of esophagus (human)
protein:increased expression:esophagus (human)

RGD

PMID:24898882 PMID:25148895

RGD:151667431, RGD:151667436

NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498

G

X-ray repair cross complementing 1

no_association
susceptibility
treatment

CTD Direct Evidence: marker/mechanism
DNA:missense mutation:cds: p.R399Q (human)
DNA:SNPs,haplotypes:multiple (human)
DNA:SNPs:exon 6, exon 9, exon 10:multiple (human)

CTD
RGD

PMID:16639733 PMID:11400117 PMID:25710005 PMID:27123143 PMID:28356949

RGD:151347444, RGD:150530501, RGD:150530634, RGD:150530505

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

G

zinc finger CCHC-type containing 12

CTD Direct Evidence: marker/mechanism

NCBI chr X:115,433,444...115,436,691
Ensembl chr X:115,433,259...115,436,692

Ferguson-Smith tumor

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

transforming growth factor, beta receptor 1

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Ferguson-Smith type epithelioma | ClinVar Annotator: match by term: Multiple self-healing squamous epithelioma

CTD
OMIM
ClinVar

PMID:2511639 PMID:2647812 PMID:5173258 PMID:8499949 PMID:16596670 More...

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

focal nonepidermolytic palmoplantar keratoderma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

keratin 16

ClinVar Annotator: match by term: Palmoplantar keratoderma, nonepidermolytic, focal

PMID:8595410 PMID:16250206 PMID:22336941 PMID:24611874 PMID:25741868 More...

NCBI chr10:85,168,357...85,171,816
Ensembl chr10:85,066,802...85,171,799

G

keratin 6c

ClinVar Annotator: match by term: Focal palmoplantar keratoderma

NCBI chr 7:132,799,608...132,804,045
Ensembl chr 7:132,799,616...132,804,045

G

spermatogenesis associated 22

ClinVar Annotator: match by term: Isolated focal non-epidermolytic palmoplantar keratoderma

NCBI chr10:57,945,272...57,963,081
Ensembl chr10:57,932,187...57,963,081

G

transient receptor potential cation channel, subfamily V, member 3

ClinVar Annotator: match by term: Isolated focal non-epidermolytic palmoplantar keratoderma

PMID:9536098 PMID:17576681 PMID:21285946 PMID:24452206 PMID:25285920 More...

NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296

focal nonepidermolytic palmoplantar keratoderma 1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

keratin 16

ClinVar Annotator: match by term: Palmoplantar keratoderma, nonepidermolytic, focal 1

PMID:8595410 PMID:16250206 PMID:22336941 PMID:22668561 PMID:24491404 More...

NCBI chr10:85,168,357...85,171,816
Ensembl chr10:85,066,802...85,171,799

focal nonepidermolytic palmoplantar keratoderma 2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

transient receptor potential cation channel, subfamily V, member 3

ClinVar Annotator: match by term: Palmoplantar keratoderma, nonepidermolytic, focal 2 | ClinVar Annotator: match by term: TRPV3-related condition

PMID:25741868 PMID:28492532

NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296

glottis squamous cell carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

WD repeat containing, antisense to TP53

disease_progression

RGD

NCBI chr10:54,282,092...54,299,908
Ensembl chr10:54,282,105...54,298,929

head and neck squamous cell carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily G member 2

CTD Direct Evidence: marker/mechanism

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

ClinVar Annotator: match by term: Lip and oral cavity carcinoma

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

aconitate decarboxylase 1

mRNA:increased expression:cranioceervical (human)

RGD

NCBI chr15:79,871,819...79,881,101
Ensembl chr15:79,871,827...79,880,529

G

AKT serine/threonine kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

ankyrin repeat domain 17

ClinVar Annotator: match by term: Lip and oral cavity carcinoma

NCBI chr14:17,723,239...17,861,841
Ensembl chr14:17,721,932...17,862,617

G

ATPase copper transporting beta

CTD Direct Evidence: marker/mechanism

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

G

beta-2 microglobulin

ClinVar Annotator: match by term: Head and neck squamous cell carcinoma | ClinVar Annotator: match by term: Squamous cell carcinoma of the head and neck

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

baculoviral IAP repeat-containing 2

exacerbates

mRNA:increased expression:head or neck skin (human)

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

ameliorates

mRNA:increased expression:head or neck skin (human)

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Lip and oral cavity carcinoma

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

caspase 8

CTD Direct Evidence: marker/mechanism

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

coiled-coil domain containing 3

ClinVar Annotator: match by term: Lip and oral cavity carcinoma

NCBI chr17:73,031,891...73,135,173
Ensembl chr17:73,035,045...73,135,337

G

cyclin A1

CTD Direct Evidence: marker/mechanism

PMID:23358896 PMID:29464035

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin A2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

disease_progression

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:26909611 PMID:29464035 PMID:9796972

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin E2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cell division cycle 73

exacerbates

protein:increased expression:squamous epithelium (human)

RGD

NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656

G

cyclin dependent kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 6

CTD Direct Evidence: marker/mechanism

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 2A

disease_progression

DNA:SNPs: :rs3731217, rs3088440 (human)
ClinVar Annotator: match by term: Lip and oral cavity carcinoma
CTD Direct Evidence: marker/mechanism

ClinVar
CTD
RGD

PMID:7718873 PMID:8153634 PMID:8668202 PMID:9166859 PMID:11687599 More...

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

chromodomain helicase DNA binding protein 4

mRNA:increased expression:head or neck skin (human)

NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541

G

claudin 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

contactin 4

ClinVar Annotator: match by term: Lip and oral cavity carcinoma

NCBI chr 4:138,624,584...139,622,499
Ensembl chr 4:139,099,152...139,621,090

G

CREB binding protein

ClinVar Annotator: match by term: Head and neck squamous cell carcinoma | ClinVar Annotator: match by term: Squamous cell carcinoma of the head and neck

PMID:21390126 PMID:21680795 PMID:21796119 PMID:22832583 PMID:23334668 More...

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

catenin beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome P450, subfamily 2, polypeptide 11

treatment

DNA:polymorphisms: :CYP2C9*2(human)

RGD

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily C, polypeptide 6

treatment

DNA:polymorphisms: :CYP2C19*2(human)

RGD

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

treatment

DNA:polymorphisms: :CYP2D6*4,CYP2D6*10(human)

RGD

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

discoidin domain receptor tyrosine kinase 2

severity

RGD

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

DNA methyltransferase 3 beta

susceptibility

DNA:SNP,haplotype:promoter:-149C>T,-579G>T(human)

RGD

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

epidermal growth factor receptor

ClinVar Annotator: match by term: Head and neck squamous cell carcinoma | ClinVar Annotator: match by term: Lip and oral cavity carcinoma | ClinVar Annotator: match by term: Squamous cell carcinoma of the head and neck

PMID:15118073 PMID:15118125 PMID:15788655 PMID:17177598 PMID:17285735 More...

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

erb-b2 receptor tyrosine kinase 2

disease_progression

RGD

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 4

severity

RGD

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

FA complementation group B

DNA:hypermethylation:promoter

RGD

NCBI chr X:29,403,771...29,420,484
Ensembl chr X:29,403,771...29,420,192

G

FA complementation group D2

RGD

NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412

G

fibroblast growth factor receptor 3

ClinVar Annotator: match by term: Head and neck squamous cell carcinoma
ClinVar Annotator: match by term: Head and neck squamous cell carcinoma | ClinVar Annotator: match by term: Squamous cell carcinoma of the head and neck

PMID:1908846 PMID:7773297 PMID:8589699 PMID:8640234 PMID:8858131 More...

NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341

G

fibroblast growth factor receptor 4

severity

DNA:SNP:exon 9: p.G388R (human)

RGD

NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242

G

fragile histidine triad diadenosine triphosphatase

ClinVar Annotator: match by term: Lip and oral cavity carcinoma

NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340

G

glutamate ionotropic receptor kainate type subunit 2

ClinVar Annotator: match by term: Lip and oral cavity carcinoma

NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375

G

homeo box A5

CTD Direct Evidence: marker/mechanism

NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234

G

homeo box D10

CTD Direct Evidence: marker/mechanism

NCBI chr 3:59,594,516...59,597,725
Ensembl chr 3:59,594,516...59,597,725

G

homeobox D11

CTD Direct Evidence: marker/mechanism

NCBI chr 3:59,584,840...59,587,257
Ensembl chr 3:59,585,039...59,586,783

G

HRas proto-oncogene, GTPase

ClinVar Annotator: match by term: Head and neck squamous cell carcinoma | ClinVar Annotator: match by term: Lip and oral cavity carcinoma | ClinVar Annotator: match by term: Squamous cell carcinoma of the head and neck

PMID:1904555 PMID:2105486 PMID:3510078 PMID:11150980 PMID:12727991 More...

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

interferon, lambda 3

CTD Direct Evidence: therapeutic

NCBI chr 1:83,814,456...83,816,096
Ensembl chr 1:83,814,564...83,816,096

G

insulin-like growth factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 1 alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 receptor accessory protein

CTD Direct Evidence: marker/mechanism

NCBI chr11:74,062,999...74,199,530
Ensembl chr11:74,070,304...74,199,530

G

interleukin 2

RGD

PMID:3263896 PMID:2787951

RGD:8662923, RGD:8662971

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

inhibitor of growth family, member 1

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Squamous cell carcinoma of the head and neck

OMIM
CTD
ClinVar

NCBI chr16:77,937,276...77,945,320
Ensembl chr16:77,937,279...77,946,264

G

insulin receptor substrate 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

JunB proto-oncogene, AP-1 transcription factor subunit

ameliorates

human cell line in a mouse model

RGD

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

KiSS-1 metastasis-suppressor

CTD Direct Evidence: therapeutic

NCBI chr13:44,775,106...44,780,707
Ensembl chr13:44,774,823...44,780,612

G

KIT proto-oncogene receptor tyrosine kinase

ClinVar Annotator: match by term: Lip and oral cavity carcinoma

PMID:22703879 PMID:24728327 PMID:25741868 PMID:28492532 PMID:31775759

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

ligand of numb-protein X 1

ClinVar Annotator: match by term: Lip and oral cavity carcinoma

NCBI chr14:33,514,429...33,617,086
Ensembl chr14:33,514,436...33,617,086

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Head and neck squamous cell carcinoma | ClinVar Annotator: match by term: Lip and oral cavity carcinoma
ClinVar Annotator: match by term: Head and neck squamous cell carcinoma | ClinVar Annotator: match by term: Lip and oral cavity carcinoma | ClinVar Annotator: match by term: Squamous cell carcinoma of the head and neck

PMID:1904555 PMID:2105486 PMID:3510078 PMID:11150980 PMID:12727991 More...

NCBI chr 1:196,299,843...196,315,170
Ensembl chr 1:196,299,846...196,315,172

G

O-6-methylguanine-DNA methyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

microRNA 155

RGD

NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718

G

microRNA 222

CTD Direct Evidence: marker/mechanism

NCBI chr X:3,428,904...3,429,006
Ensembl chr X:3,428,904...3,429,006

G

microRNA 494

exacerbates

RGD

NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793

G

matrix metallopeptidase 2

ClinVar Annotator: match by term: Lip and oral cavity carcinoma

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

NLR family, apoptosis inhibitory protein 6

ameliorates

mRNA:increased expression:head or neck skin (human)

NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542

G

nicotinamide phosphoribosyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

N-myc downstream regulated 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL

CTD Direct Evidence: marker/mechanism

NCBI chr X:150,775,034...150,807,161
Ensembl chr X:150,775,080...150,807,142

G

8-oxoguanine DNA glycosylase

susceptibility

DNA:SNP: :rs1052133 (human)

RGD

PMID:22081374 PMID:21727658

RGD:8657144, RGD:8657147

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lip and oral cavity carcinoma
ClinVar Annotator: match by term: Head and neck squamous cell carcinoma | ClinVar Annotator: match by term: Squamous cell carcinoma of the head and neck

PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 More...

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

protein phosphatase 2 scaffold subunit A alpha

ClinVar Annotator: match by term: Head and neck squamous cell carcinoma | ClinVar Annotator: match by term: Squamous cell carcinoma of the head and neck

PMID:25741868 PMID:26168268 PMID:26619011 PMID:28492532 PMID:31687265

NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129

G

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

ClinVar Annotator: match by term: Lip and oral cavity carcinoma

NCBI chr 5:7,937,692...8,253,112
Ensembl chr 5:7,942,573...8,253,068

G

phosphatase and tensin homolog

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Head and neck squamous cell carcinoma | ClinVar Annotator: match by term: Squamous cell carcinoma of the head and neck

PMID:11801303 PMID:23873848 PMID:24033266 PMID:24055113 PMID:25741868 More...

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin-endoperoxide synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 13

susceptibility

DNA:SNPs:cds:c.4566 A>G(I1522M)(rs2230600), c.6241 T>G (Y2081D)(rs989902)(human)
DNA:missense mutations:cds:p.I1522M, p.Y2081D (human)

RGD

PMID:19892796 PMID:19672627

RGD:152176661, RGD:152176665

NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563

G

RAS guanyl releasing protein 3

ClinVar Annotator: match by term: Lip and oral cavity carcinoma

NCBI chr 6:19,895,361...19,993,945
Ensembl chr 6:19,895,390...19,958,578

G

RB transcriptional corepressor 1

ClinVar Annotator: match by term: Lip and oral cavity carcinoma

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

sterile alpha motif domain containing 4A

ClinVar Annotator: match by term: Lip and oral cavity carcinoma

NCBI chr15:20,135,994...20,352,131
Ensembl chr15:20,134,377...20,348,380

G

serpin family E member 1

severity

protein:increased expression:oral mucosa (human)

RGD

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

SMAD family member 4

RGD

NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438

G

syntrophin, beta 1

ClinVar Annotator: match by term: Lip and oral cavity carcinoma

NCBI chr 7:87,060,926...87,329,315
Ensembl chr 7:87,060,926...87,329,315

G

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

signal transducer and activator of transcription 3

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:27064016 PMID:24395569

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

serine/threonine kinase 11

ClinVar Annotator: match by term: Lip and oral cavity carcinoma

PMID:25741868 PMID:26467025 PMID:28492532 PMID:31775759 PMID:34326862

NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315

G

TNF receptor superfamily member 10b

DNA:missense mutation:cds:p.E228A (c.683A>C) (human)

RGD

NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467

G

tumor protein p53

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Head and neck squamous cell carcinoma | ClinVar Annotator: match by term: Lip and oral cavity carcinoma | ClinVar Annotator: match by term: Squamous cell carcinoma of the head and neck | ClinVar Annotator: match by term: Squamous cell carcinoma, head and neck, somatic

PMID:124622 PMID:253702 PMID:960674 PMID:1349102 PMID:1349175 More...

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

vesicle-associated membrane protein 7

CTD Direct Evidence: marker/mechanism

NCBI chr12:16,728,486...16,764,261
Ensembl chr12:16,728,524...16,764,097

G

WEE1 G2 checkpoint kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688

G

WD repeat containing, antisense to TP53

treatment

ClinVar Annotator: match by term: Squamous cell carcinoma of the head and neck

PMID:25070141 PMID:25456005

RGD:21081533, RGD:21081529

NCBI chr10:54,282,092...54,299,908
Ensembl chr10:54,282,105...54,298,929

G

Yes1 associated transcriptional regulator

CTD Direct Evidence: marker/mechanism

NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010

Ichthyosis Hystrix Gravior

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

keratin 10

ClinVar Annotator: match by term: Ichthyosis hystrix gravior

PMID:17355236 PMID:27212473

NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701

IMMUNODEFICIENCY 123 WITH HPV-RELATED VERRUCOSIS

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Cd28 molecule

ClinVar Annotator: match by term: Immunodeficiency 123 with HPV-related verrucosis

NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685

inverted papilloma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin-dependent kinase inhibitor 1A

protein:increased expression:nucleus:

RGD

PMID:19863319 PMID:21608063

RGD:8662353, RGD:8662357

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

hepatocyte growth factor

protein:increased expression:inferior nasal concha:

RGD

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

kinase insert domain receptor

protein:increased expression:inferior nasal concha:

RGD

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

vascular endothelial growth factor A

protein:increased expression:inferior nasal concha:

RGD

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

keratoacanthoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

notch receptor 1

ClinVar Annotator: match by term: Keratoacanthoma

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

notch receptor 2

ClinVar Annotator: match by term: Keratoacanthoma

NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

ClinVar Annotator: match by term: Keratoacanthoma

PMID:22949682 PMID:23246288 PMID:25741868 PMID:27283355 PMID:28151489 More...

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

Laryngeal Papillomatosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

prostaglandin-endoperoxide synthase 2

RGD

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

serpin family A member 3N

protein:decreased expression:serum

RGD

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

transporter 1, ATP binding cassette subfamily B member

RGD

NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901

laryngeal squamous cell carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine deaminase

protein:decreased activity:larynx

RGD

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

catalase

protein:increased activity:larynx

RGD

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cell division cycle 73

disease_progression

protein:decreased expression:larynx (human)

RGD

NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656

G

cyclin-dependent kinase inhibitor 1A

RGD

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

chromodomain helicase DNA binding protein 4

exacerbates

mRNA:increased expression:larynx (human)

NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541

G

epidermal growth factor receptor

disease_progression

RGD

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

erb-b2 receptor tyrosine kinase 2

disease_progression

RGD

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 3

disease_progression

RGD

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

erb-b2 receptor tyrosine kinase 4

disease_progression

RGD

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

forkhead box L2

exacerbates

mRNA:increased expression:larynx (human)

RGD

NCBI chr 8:99,512,971...99,514,500
Ensembl chr 8:99,513,303...99,514,427

G

glutathione peroxidase 1

disease_progression
no_association

protein:increased expression:larynx (human)
DNA:missense mutation:CDS:p.P198L (human)
DNA:missense mutation:CDS:p.P198L (rs1050450) (human)

RGD

PMID:28641905 PMID:24074040 PMID:27188866

RGD:152995454, RGD:152995493, RGD:152995455

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

mitogen activated protein kinase kinase 4

severity

associated with Neoplasm Metastasis; protein:mRNA,increased expression:larynx epithelium (human)

RGD

NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993

G

microRNA 10a

severity

miRNA:decreased expression:blood serum (human)

NCBI chr10:81,283,171...81,283,280
Ensembl chr10:81,283,171...81,283,280

G

microRNA 136

RNA:decreased expression:larynx (human)

RGD

NCBI chr 6:128,549,096...128,549,177
Ensembl chr 6:128,549,096...128,549,177

G

microRNA 21

exacerbates

miRNA:increased expression:blood serum (human)

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 31

disease_progression

RNA:decreased expression:mucosa of larynx (human)

RGD

NCBI chr 5:103,599,038...103,599,143

G

mutL homolog 1

disease_progression

mRNA:decreased expression:larynx

RGD

NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617

G

matrix metallopeptidase 2

RGD

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

mutS homolog 2

disease_progression

mRNA:decreased expression:larynx

RGD

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

N-acetyltransferase 2

susceptibility

DNA:polymorphisms: :

RGD

PMID:19922706 PMID:16155914

RGD:5131602, RGD:5131856

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

phospholipase C, gamma 1

ameliorates

mRNA:increased expression:larynx (human)

RGD

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

RELA proto-oncogene, NF-kB subunit

severity

associated with Neoplasm Metastasis; protein:mRNA,increased expression:larynx epithelium (human)

RGD

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

xanthine dehydrogenase

protein:increased activity:larynx

RGD

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

G

X-ray repair cross complementing 1

ClinVar Annotator: match by term: Laryngeal squamous cell carcinoma

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

lung squamous cell carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ALK receptor tyrosine kinase

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:24033266 PMID:24728327 PMID:25741868 PMID:28492532

NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034

G

Rho GTPase activating protein 44

mRNA:decreased expression:lung (human)

RGD

NCBI chr10:49,655,583...49,822,876
Ensembl chr10:49,655,584...49,824,297

G

AT-rich interaction domain 1A

exacerbates

protein:decreased expression:lung (human)

NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564

G

actin related protein 2/3 complex, subunit 5

mRNA:increased expression:lung (human)

RGD

NCBI chr13:64,904,504...64,913,413
Ensembl chr13:64,887,136...64,913,410

G

ATM serine/threonine kinase

susceptibility

DNA:SNP:intron:(rs228589) (human)

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATRX, chromatin remodeler

severity

RGD

NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330

G

baculoviral IAP repeat-containing 5

disease_progression

mRNA:increased expression:lung (human)

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

baculoviral IAP repeat-containing 6

disease_progression

mRNA:increased expression:lung (human)

NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:12068308 PMID:12460918 PMID:12460919 PMID:12960123 PMID:14612909 More...

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

basigin

mRNA:increased expression:lung

RGD

NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387

G

Cbl proto-oncogene B

disease_progression

RGD

NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839

G

cyclin D1

disease_progression

protein:increased expression:lung

RGD

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

DNA:hypermethylation:promoter

RGD

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin-dependent kinase 4

protein:increased expression:lung

RGD

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 2A

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:8552400 PMID:8573142 PMID:9053859 PMID:9660926 PMID:10498896 More...

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

chromodomain helicase DNA binding protein 4

mRNA:increased expression:lung (human)

NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541

G

cholinergic receptor nicotinic alpha 5 subunit

susceptibility

DNA:SNP: :rs503464(human)
mRNA:increased expression:lung

RGD

PMID:23314339 PMID:20124469

RGD:150527849, RGD:150527851

NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146

G

cholinergic receptor nicotinic beta 4 subunit

susceptibility

mRNA:increased expression:lung
DNA:hypomethylation:promoter:
DNA:SNP:: (rs7178270) (human)

RGD

PMID:20124469 PMID:22945651 PMID:23397474

RGD:150527851, RGD:151361154, RGD:151361148

NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027

G

CLPTM1-like

susceptibility
no_association

mRNA:increased expression:lung
DNA:SNP: :rs401681(human)
DNA:SNP::rs401681(human)
DNA:SNP:: rs31490(human)

RGD

PMID:24366883 PMID:24386361 PMID:24861918 PMID:23908149

RGD:150530483, RGD:150537098, RGD:150530499, RGD:150530498

NCBI chr 1:29,667,545...29,683,530
Ensembl chr 1:29,667,545...29,683,530

G

CREB binding protein

ClinVar Annotator: match by term: Squamous cell carcinoma of lung

PMID:21390126 PMID:21680795 PMID:21796119 PMID:22832583 PMID:23334668 More...

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

colony stimulating factor 1 receptor

protein:increased expression:lung (human)

RGD

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

catenin beta 1

disease_progression

protein:increased expression:lung

RGD

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome c, somatic

treatment

RGD

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily b, polypeptide 1

susceptibility

Carcinoma, Squamous Cell;DNA:snp:cds:p.A119S (human)

RGD

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

discoidin domain receptor tyrosine kinase 2

severity

ClinVar Annotator: match by term: Squamous cell lung carcinoma
mRNA:increased expression:lung

PMID:22328973 PMID:25741868 PMID:26206333 PMID:28492532 PMID:24885564 More...

RGD:150429702, RGD:150429703

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

E2F transcription factor 1

treatment

RGD

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 3

RGD

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

eukaryotic translation elongation factor 2

disease_progression

protein:increased expression:lung (human)

NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183

G

epidermal growth factor receptor

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:20942962 PMID:24033266 PMID:25382819 PMID:25741868 PMID:27294619 More...

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

empty spiracles homeobox 2

exacerbates

protein:decreased expression:lung (human)

RGD

NCBI chr 1:258,626,584...258,633,594
Ensembl chr 1:258,626,584...258,633,594

G

ERCC excision repair 6, chromatin remodeling factor

mRNA, protein:increased expression:lung (human)

RGD

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

ERCC excision repair 6 like, spindle assembly checkpoint helicase

mRNA:increased expression:lung (human)

RGD

NCBI chr X:67,245,414...67,261,222
Ensembl chr X:67,245,414...67,280,756

G

fibroblast activation protein, alpha

disease_progression

RGD

NCBI chr 3:47,138,823...47,207,671
Ensembl chr 3:47,138,813...47,225,545

G

F-box and WD repeat domain containing 7

ClinVar Annotator: match by term: Squamous cell carcinoma of lung | ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:25741868 PMID:26619011

NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941

G

fibroblast growth factor 9

mRNA:decreased expression:lung (human)

RGD

NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309

G

fibroblast growth factor receptor 2

ClinVar Annotator: match by term: Squamous cell lung carcinoma

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

fibroblast growth factor receptor 3

ClinVar Annotator: match by term: Squamous cell carcinoma of lung | ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:8589699 PMID:10471491 PMID:11038465 PMID:11879084 PMID:15772091 More...

NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341

G

fibroblast growth factor receptor 4

disease_progression

human cells in mouse model

RGD

NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242

G

frizzled-related protein

protein:decreased expression:lung (human)

RGD

NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208

G

far upstream element binding protein 1

mRNA:decreased expression:lung (human)

RGD

NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602

G

glutathione peroxidase 1

susceptibility

DNA:missense mutation:CDS:p.P198L (rs1050450) (human)
DNA:missense mutation:CDS:p.P200L (rs1050450) (human)

RGD

PMID:16797832 PMID:18298806

RGD:152995481, RGD:152995507

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

HRas proto-oncogene, GTPase

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:16372351 PMID:24033266 PMID:25741868 PMID:28492532

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

isocitrate dehydrogenase (NADP(+)) 1

protein:increased expression:blood plasma (human)

RGD

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

G

isocitrate dehydrogenase (NADP(+)) 2

severity
susceptibility

protein:increased expression:lung (human)
protein:increased expression:blood serum (human)
DNA:SNP:CD: (rs11540478) C>T (human)

RGD

PMID:30128035 PMID:29465809 PMID:27649069

RGD:149735564, RGD:149735567, RGD:149735566

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

KIT proto-oncogene receptor tyrosine kinase

ClinVar Annotator: match by term: Squamous cell lung carcinoma

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

lysine methyltransferase 2D

disease_progression

RGD

PMID:24323028 PMID:30885352 PMID:28177435

RGD:150523770, RGD:150523777, RGD:150523776

NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:6695174 PMID:15696205 PMID:17704260 PMID:26242988 PMID:28492532

NCBI chr 4:178,185,418...178,218,484

G

laminin subunit gamma 2

disease_progression

RGD

NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:16372351 PMID:24033266 PMID:25741868 PMID:28492532

NCBI chr 1:196,299,843...196,315,170
Ensembl chr 1:196,299,846...196,315,172

G

mitogen activated protein kinase kinase 1

ClinVar Annotator: match by term: Squamous cell lung carcinoma

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 7

mRNA:decreased expression:lung (human)

RGD

NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222

G

MET proto-oncogene, receptor tyrosine kinase

ClinVar Annotator: match by term: Squamous cell lung carcinoma

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

microRNA 154

associated with nicotine dependence; RNA:decreased expression:blood serum (human)

RGD

NCBI chr 6:128,752,947...128,753,030
Ensembl chr 6:128,752,947...128,753,030

G

microRNA 193a

exacerbates

DNA:Hypermethylation

RGD

NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454

G

microRNA 20a

RGD

NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168

G

microRNA 210

miRNA:increased expression:sputum (human)

RGD

NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454

G

microRNA 31

severity

RNA:increased expression:blood serum (human)
RNA:increased expression:lung (human)

RGD

PMID:21658006 PMID:21890451

RGD:152998938, RGD:152998950

NCBI chr 5:103,599,038...103,599,143

G

microRNA 497

RGD

NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584

G

microRNA 9-3

exacerbates

DNA:Hypermethylation

RGD

NCBI chr 1:133,440,049...133,440,138

G

platelet derived growth factor receptor alpha

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:24033266 PMID:25741868 PMID:28492532

NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

ClinVar Annotator: match by term: Squamous cell lung carcinoma

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

DNA polymerase epsilon, catalytic subunit

ameliorates

DNA:mutations:multiple (human)

RGD

NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939

G

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

mRNA:increased expression:lung (human)

RGD

NCBI chr 5:7,937,692...8,253,112
Ensembl chr 5:7,942,573...8,253,068

G

patched 1

disease_progression

DNA:CNVs

RGD

NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333

G

phosphatase and tensin homolog

ClinVar Annotator: match by term: Squamous cell lung carcinoma

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

protein tyrosine kinase 2

severity

RGD

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine phosphatase, non-receptor type 11

ClinVar Annotator: match by term: Squamous cell carcinoma of lung

PMID:11704759 PMID:12634870 PMID:12717436 PMID:14644997 PMID:14974085 More...

NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925

G

protein tyrosine phosphatase, non-receptor type 13

susceptibility
severity

mRNA,protein:decreased expression:lung
DNA:missense mutations:cds:p.I1522M, p.Y2081D (human)

RGD

PMID:22245727 PMID:19672627 PMID:23906871

RGD:152176663, RGD:152176665, RGD:152176664

NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563

G

protein tyrosine phosphatase, receptor type, J

susceptibility

DNA:missense mutations:cds:p.R326Q, p.Q276P (human)

RGD

NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260

G

RAD52 homolog, DNA repair protein

ameliorates
susceptibility

DNA:SNP: (rs6489769) (human)

RGD

PMID:28415565 PMID:22585858

RGD:151660334, RGD:151660345

NCBI chr 4:153,106,062...153,128,598
Ensembl chr 4:153,106,062...153,128,207

G

surfactant protein B

susceptibility

DNA:polymorphism:intron (human)
DNA:variants:intron:

RGD

PMID:16570259 PMID:12107845

RGD:4143389, RGD:151667424

NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436

G

solute carrier family 7 member 5

RGD

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

SRY-box transcription factor 30

disease_progression

RGD

NCBI chr10:30,417,499...30,446,441
Ensembl chr10:30,418,473...30,446,453

G

SRC proto-oncogene, non-receptor tyrosine kinase

severity

RGD

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

serine and arginine rich splicing factor 1

protein:increased expression:lung epithelium

RGD

NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336

G

serine and arginine rich splicing factor 2

protein:increased expression:lung epithelium,nucleus

RGD

NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338

G

serine/threonine kinase 11

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:15800014 PMID:17676035 PMID:25741868 PMID:28492532

NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315

G

sulfotransferase family 1A member 1

DNA:SNP:exon:p.R213H, 638G>A (human)

RGD

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

telomerase reverse transcriptase

susceptibility

DNA:SNP:: rs2853669(human)
DNA:SNP::rs33963617(human)

RGD

PMID:23908149 PMID:31935503

RGD:150530498, RGD:150530635

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

tumor protein p53

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:1349175 PMID:1359493 PMID:1565143 PMID:1565144 PMID:1591732 More...

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p73

treatment

DNA:SNP:: rs2273953(human)
mRNA:increased expression:lung (human)

PMID:30420492 PMID:27246533

RGD:151347580, RGD:151347584

NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128

malignant mesothelioma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activin A receptor type 1B

ameliorates

RGD

NCBI chr 7:132,286,266...132,329,679
Ensembl chr 7:132,286,275...132,329,673

G

adenosine deaminase

treatment

RGD

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

ADAM metallopeptidase with thrombospondin type 1 motif, 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:34,920,992...35,126,465
Ensembl chr10:34,921,049...35,123,821

G

argonaute RISC component 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:138,722,111...138,757,118
Ensembl chr 5:138,722,111...138,773,546

G

argonaute RISC catalytic component 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974

G

annexin A2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

apolipoprotein A1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

BRCA1 associated deubiquitinase 1

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:24928783 PMID:25231345 PMID:26463840 PMID:26928227 PMID:29112861 More...

NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535

G

BCL10, immune signaling adaptor

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Mesothelioma, malignant | ClinVar Annotator: match by term: Mesothelioma, somatic

OMIM
CTD
ClinVar

PMID:9989495 PMID:10380920 PMID:10408400 PMID:25741868 PMID:28492532

NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523

G

BCL2, apoptosis regulator

CTD Direct Evidence: marker/mechanism

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

complement C9

CTD Direct Evidence: marker/mechanism

NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338

G

calbindin 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438

G

C-C motif chemokine ligand 27

CTD Direct Evidence: marker/mechanism

NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506

G

C-C motif chemokine ligand 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 5

CTD Direct Evidence: marker/mechanism

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

CTD Direct Evidence: marker/mechanism

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

cyclin E2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

CD40 molecule

treatment

RGD

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

cadherin 5

CTD Direct Evidence: marker/mechanism

NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368

G

cyclin-dependent kinase 6

CTD Direct Evidence: marker/mechanism

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 1A

CTD Direct Evidence: marker/mechanism

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

CTD Direct Evidence: marker/mechanism

PMID:19223589 PMID:21526190 PMID:29112861 PMID:37441092

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

cilia and flagella associated protein 45

CTD Direct Evidence: marker/mechanism

NCBI chr13:84,989,474...85,012,880
Ensembl chr13:84,981,728...85,012,878

G

claudin 10

CTD Direct Evidence: marker/mechanism

NCBI chr15:95,862,785...95,954,526
Ensembl chr15:95,862,760...95,954,526

G

claudin 15

CTD Direct Evidence: marker/mechanism

NCBI chr12:19,698,167...19,708,419
Ensembl chr12:19,698,337...19,706,819

G

claudin 4

CTD Direct Evidence: marker/mechanism

NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436

G

claudin 5

CTD Direct Evidence: marker/mechanism

NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992

G

claudin 8

CTD Direct Evidence: marker/mechanism

NCBI chr11:27,875,857...27,878,106
Ensembl chr11:27,875,692...27,878,513

G

C-type lectin domain containing 11A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:94,800,456...94,809,002
Ensembl chr 1:94,801,496...94,804,633

G

collagen type XII alpha 1 chain

CTD Direct Evidence: marker/mechanism

NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686

G

COPI coat complex subunit gamma 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:120,366,540...120,392,502
Ensembl chr 4:120,366,542...120,415,616

G

colony stimulating factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

catenin beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 12

CTD Direct Evidence: marker/mechanism

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 13

CTD Direct Evidence: marker/mechanism

NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933

G

C-X-C motif chemokine ligand 9

CTD Direct Evidence: marker/mechanism

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

DEAD-box helicase 3, X-linked

CTD Direct Evidence: marker/mechanism

NCBI chr X:9,479,532...9,493,169
Ensembl chr X:9,479,532...9,493,168

G

DEAD-box helicase 51

CTD Direct Evidence: marker/mechanism

NCBI chr12:46,011,303...46,015,989
Ensembl chr12:46,011,070...46,016,200

G

EGF containing fibulin extracellular matrix protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018

G

epidermal growth factor receptor

CTD Direct Evidence: marker/mechanism

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

ecto-NOX disulfide-thiol exchanger 2

CTD Direct Evidence: marker/mechanism

NCBI chr X:128,270,941...128,593,074
Ensembl chr X:128,271,074...128,593,039

G

epoxide hydrolase 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

coagulation factor IX

CTD Direct Evidence: marker/mechanism

NCBI chr X:138,352,334...138,396,835
Ensembl chr X:138,352,298...138,396,835

G

FYVE, RhoGEF and PH domain containing 6

CTD Direct Evidence: marker/mechanism

NCBI chr 7:28,597,609...28,712,908
Ensembl chr 7:28,597,609...28,712,456

G

fibroblast growth factor 18

CTD Direct Evidence: marker/mechanism

NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818

G

fibroblast growth factor 9

CTD Direct Evidence: marker/mechanism

NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309

G

fibronectin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

ferritin heavy chain 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

G protein-coupled receptor 27

CTD Direct Evidence: marker/mechanism

NCBI chr 4:132,328,364...132,329,497
Ensembl chr 4:132,328,364...132,329,497

G

G protein-coupled receptor 37

CTD Direct Evidence: marker/mechanism

NCBI chr 4:54,138,860...54,160,927
Ensembl chr 4:54,138,870...54,161,001

G

glutathione S-transferase mu 1

DNA:deletion:cds (human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16697254 PMID:7606714

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

histone deacetylase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164

G

hephaestin

CTD Direct Evidence: marker/mechanism

NCBI chr X:61,151,131...61,402,980
Ensembl chr X:61,296,345...61,402,980

G

hepatocyte growth factor

CTD Direct Evidence: marker/mechanism

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

HtrA serine peptidase 1

disease_progression

protein:increased expression:mesothelium (human)

RGD

NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379

G

intercellular adhesion molecule 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:91,308,608...91,319,536
Ensembl chr10:91,308,538...91,315,293

G

interferon gamma

CTD Direct Evidence: marker/mechanism

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 2 mRNA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865

G

interleukin 12B

CTD Direct Evidence: marker/mechanism

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 1 alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 2 receptor subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697

G

interleukin 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066

G

interleukin 4

CTD Direct Evidence: marker/mechanism

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

CTD Direct Evidence: marker/mechanism

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin-linked kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140

G

lysine acetyltransferase 5

CTD Direct Evidence: therapeutic

NCBI chr 1:202,895,751...202,903,178
Ensembl chr 1:202,895,751...202,903,458