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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:papillary adenocarcinoma
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Accession:DOID:3112 term browser browse the term
Definition:An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which form complex papillary structures and exhibit compressive, destructive growth that replaces the normal tissue. (DO)
Synonyms:exact_synonym: infiltrating and papillary adenocarcinoma;   infiltrating papillary adenocarcinoma;   papillary adenocarcinomas
 primary_id: MESH:D000231
 xref: ICDO:8260/3;   NCI:C2853;   NCI:C7438
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
gastric papillary adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli1 GLI family zinc finger 1 ISO protein:increased expression:stomach RGD PMID:17259107 RGD:150340552 NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:65,042,237...65,054,540 		JBrowse link
G Smo smoothened, frizzled class receptor ISO protein:increased expression:stomach RGD PMID:17259107 RGD:150340552 NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:59,311,041...59,341,281 		JBrowse link
papillary thyroid carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase susceptibility ISO associated with Radiation-Induced Neoplasms;DNA:SNPs,haplotypes:exon 39,intron 22,intron 48: p.D1853N, IVS22-77 T>C, IVS48 + 238 C>G (rs1801516, rs664677, rs609429) RGD PMID:19286843 RGD:401850780 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629 		JBrowse link
G Begain brain-enriched guanylate kinase-associated ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:133,708,010...133,744,264
Ensembl chr 6:133,708,007...133,744,526 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase onset ISO
ISS
IMP 		DNA:mutation:cds:p.V600E(human)
ClinVar Annotator: match by term: Papillary thyroid carcinoma
OMIM:188550
DNA:missense mutation:cds;p.V600E(rat)
CTD Direct Evidence: marker/mechanism 		ClinVar
MouseDO
CTD
RGD		 PMID:12068308 PMID:12198537 PMID:12447372 PMID:12619120 PMID:12644542 More... RGD:7241798, RGD:32716372 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931 		JBrowse link
G Brd4 bromodomain containing 4 ISO mRNA, protein:increased expression:thyroid RGD PMID:26707881 RGD:11085509 NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,866,997...11,946,923 		JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 ISO mRNA:increased expression:thyroid gland RGD PMID:23569218 RGD:18337285 NCBI chr 5:155,958,116...155,959,897
Ensembl chr 5:155,957,878...155,961,058 		JBrowse link
G Cat catalase ISO protein:increased activity:plasma: RGD PMID:20204550 RGD:9068926 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cbx7 chromobox 7 ISO mRNA,protein,DNA:decreased expression, loss of heterozygosity:thyroid gland:
mRNA:decreased expression:thyroid gland (mouse) 		RGD PMID:18701502 PMID:18701502 RGD:9587357, RGD:9587357 NCBI chr 7:113,341,030...113,358,716
Ensembl chr 7:113,341,030...113,358,346 		JBrowse link
G Ccdc6 coiled-coil domain containing 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr20:18,431,243...18,527,227
Ensembl chr20:18,431,243...18,527,227 		JBrowse link
G Ccnd1 cyclin D1 ISO mRNA:increased expression:thyroid RGD PMID:28677753 RGD:13792605 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdh1 cadherin 1 ISO DNA:hypermethylation:promoter RGD PMID:25520863 RGD:13792554 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Ctnnb1 catenin beta 1 disease_progression ISO mRNA:increased expression:thyroid RGD PMID:29498921 PMID:28677753 RGD:13792558, RGD:13792605 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Dio3 iodothyronine deiodinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:135,107,072...135,108,933
Ensembl chr 6:135,107,074...135,107,985 		JBrowse link
G Dio3os DIO3 opposite strand upstream RNA ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:135,436,375...135,502,117
Ensembl chr 6:135,430,750...135,502,116 		JBrowse link
G Kmt2d lysine methyltransferase 2D ISO associated with familial adenomatous polyposis;DNA:missense mutations, nonsense mutation RGD PMID:32024448 RGD:150523759 NCBI chr 7:131,859,696...131,901,032
Ensembl chr 7:131,859,696...131,900,072 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 ISO mRNA:increased expression:thyroid RGD PMID:28677753 RGD:13792605 NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929 		JBrowse link
G Lig4 DNA ligase 4 ISO ClinVar Annotator: match by term: Papillary thyroid carcinoma ClinVar PMID:25741868 NCBI chr16:86,220,345...86,228,930
Ensembl chr16:86,220,279...86,229,926 		JBrowse link
G Mir127 microRNA 127 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,328,454...134,328,550
Ensembl chr 6:134,328,454...134,328,550 		JBrowse link
G Mir134 microRNA 134 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,570,313...134,570,385 JBrowse link
G Mir136 microRNA 136 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,331,335...134,331,416
Ensembl chr 6:134,331,335...134,331,416 		JBrowse link
G Mir154 microRNA 154 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,574,352...134,574,435
Ensembl chr 6:134,574,352...134,574,435 		JBrowse link
G Mir299a microRNA 299B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,545,040...134,545,157 JBrowse link
G Mir300 microRNA 300 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,559,918...134,559,996
Ensembl chr 6:134,559,910...134,559,999 		JBrowse link
G Mir323 microRNA 323 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,546,944...134,547,029
Ensembl chr 6:134,546,944...134,547,029 		JBrowse link
G Mir337 microRNA 337 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,321,142...134,321,238
Ensembl chr 6:134,321,141...134,321,237 		JBrowse link
G Mir3581 microRNA 3581 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,579,184...134,579,263 JBrowse link
G Mir370 microRNA 370 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,354,491...134,354,569
Ensembl chr 6:134,354,491...134,354,569 		JBrowse link
G Mir377 microRNA 377 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,576,456...134,576,527 JBrowse link
G Mir381 microRNA 381 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,562,381...134,562,441 JBrowse link
G Mir382 microRNA 382 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,569,944...134,570,023 JBrowse link
G Mir409 microRNA 409 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,579,185...134,579,261 JBrowse link
G Mir410 microRNA 410 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,579,763...134,579,838
Ensembl chr 6:134,579,759...134,579,839 		JBrowse link
G Mir411 microRNA 411 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,544,594...134,544,669
Ensembl chr 6:134,544,589...134,544,684 		JBrowse link
G Mir412 microRNA 412 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,579,337...134,579,406
Ensembl chr 6:134,579,331...134,579,410 		JBrowse link
G Mir431 microRNA 431 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,326,449...134,326,562
Ensembl chr 6:134,326,449...134,326,562 		JBrowse link
G Mir433 microRNA 433 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,327,358...134,327,450
Ensembl chr 6:134,327,351...134,327,456 		JBrowse link
G Mir487b microRNA 487b ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,562,890...134,562,971
Ensembl chr 6:134,562,890...134,562,971 		JBrowse link
G Mir494 microRNA 494 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,550,115...134,550,197
Ensembl chr 6:134,550,114...134,550,198 		JBrowse link
G Mir496 microRNA 496 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,575,049...134,575,127
Ensembl chr 6:134,575,049...134,575,127 		JBrowse link
G Mir770 microRNA 770 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:134,298,084...134,298,159
Ensembl chr 6:134,298,076...134,298,169 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO mRNA:increased expression:thyroid RGD PMID:28677753 RGD:13792605 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nkx2-1 NK2 homeobox 1 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 6:79,731,677...79,735,952
Ensembl chr 6:79,731,677...79,736,441 		JBrowse link
G Palb2 partner and localizer of BRCA2 ISO ClinVar Annotator: match by term: Papillary thyroid carcinoma ClinVar PMID:25085752 PMID:25741868 PMID:28492532 NCBI chr 1:186,096,312...186,120,284
Ensembl chr 1:186,096,312...186,120,302 		JBrowse link
G Plau plasminogen activator, urokinase severity ISO mRNA:increased expression:thyroid gland (human) RGD PMID:22702340 RGD:7241798 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030 		JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:135,282,947...135,419,591
Ensembl chr 6:135,324,067...135,419,597 		JBrowse link
G Rap1gap Rap1 GTPase-activating protein ISO protein:decreased expression:thyroid gland (human) RGD PMID:19066305 RGD:9835342 NCBI chr 5:155,157,511...155,222,622
Ensembl chr 5:155,157,558...155,222,622 		JBrowse link
G Ret ret proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:152,998,812...153,040,556 		JBrowse link
G Runx3 RUNX family transcription factor 3 ISO DNA:hypermethylation:promoter RGD PMID:25520863 RGD:13792554 NCBI chr 5:152,644,270...152,702,835
Ensembl chr 5:152,644,270...152,702,835 		JBrowse link
G Rxrg retinoid X receptor gamma ISO mRNA:increased expression:thyroid RGD PMID:28677753 RGD:13792605 NCBI chr13:82,276,330...82,318,097
Ensembl chr13:82,276,291...82,318,095 		JBrowse link
G Snai1 snail family transcriptional repressor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 3:176,667,476...176,671,965 JBrowse link
G Snai2 snail family transcriptional repressor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349 		JBrowse link
G Tp53 tumor protein p53 susceptibility ISO associated with Radiation-Induced Neoplasms;DNA:SNPs, haplotypes:exon 4: p.R72P (rs1042522) (human) RGD PMID:19286843 RGD:401850780 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tpm3 tropomyosin 3 ISO mRNA:increased expression:thyroid RGD PMID:28677753 RGD:13792605 NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:177,814,883...177,842,660 		JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:133,539,744...133,571,645 		JBrowse link
G Wdr20 WD repeat domain 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 6:135,572,502...135,642,688
Ensembl chr 6:135,572,893...135,642,688 		JBrowse link
G Wdr3 WD repeat domain 3 susceptibility ISO DNA:snps, haplotype:introns: c.500+239G>A, c.*1-2382A>C (rs3765501, rs4658973) (human) RGD PMID:20578902 RGD:11041898 NCBI chr 2:190,194,474...190,217,087
Ensembl chr 2:190,194,474...190,217,087 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO DNA:SNP:exon 10: p.R399Q (rs25487) (Human) RGD PMID:19286843 RGD:401850780 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:89,268,644...89,296,613 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr17:56,644,397...56,811,155
Ensembl chr17:56,644,397...56,810,745 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 3:49,624,028...49,754,323
Ensembl chr 3:49,624,028...49,754,323 		JBrowse link
Thyroid Cancer, Nonmedullary, 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxe1 forkhead box E1 ISO ClinVar Annotator: match by term: FOXE1-related disorder | ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 4 OMIM
ClinVar		 PMID:25381600 PMID:25741868 PMID:28444304 PMID:32428920 NCBI chr 5:65,425,630...65,428,438
Ensembl chr 5:65,425,630...65,428,438 		JBrowse link
Thyroid Cancer, Nonmedullary, 5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Habp2 hyaluronan binding protein 2 susceptibility ISO ClinVar Annotator: match by term: HABP2-related condition | ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 5 ClinVar
OMIM		 PMID:12138371 PMID:12578864 PMID:15486068 PMID:25741868 PMID:26222560 More... NCBI chr 1:265,321,084...265,355,375
Ensembl chr 1:265,303,172...265,355,374 		JBrowse link
Thyroid Carcinoma, Nonmedullary 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras KRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 1 ClinVar NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Nkx2-1 NK2 homeobox 1 ISO OMIM NCBI chr 6:79,731,677...79,735,952
Ensembl chr 6:79,731,677...79,736,441 		JBrowse link
G Pcm1 pericentriolar material 1 ISO ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 1 ClinVar PMID:10980597 PMID:25741868 NCBI chr16:57,711,833...57,808,842
Ensembl chr16:57,711,833...57,808,599 		JBrowse link
G Rint1 RAD50 interactor 1 ISO ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 1 ClinVar PMID:16199547 PMID:25741868 PMID:28492532 PMID:31204009 PMID:33471991 NCBI chr 4:12,211,806...12,248,117
Ensembl chr 4:12,213,156...12,248,117 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14566
    disease of cellular proliferation 5586
      cancer 4230
        cell type cancer 2903
          carcinoma 2518
            adenocarcinoma 1700
              papillary adenocarcinoma 66
                aggressive digital papillary adenocarcinoma 0
                bladder papillary clear cell adenocarcinoma 0
                eccrine papillary adenocarcinoma 0
                fallopian tube papillary adenocarcinoma 0
                gastric papillary adenocarcinoma 2
                lung papillary adenocarcinoma 0
                papillary extrahepatic bile duct adenocarcinoma 0
                papillary serous adenocarcinoma 0
                papillary thymic adenocarcinoma 0
                papillary thyroid carcinoma + 64
                peritoneal serous papillary adenocarcinoma 0
paths to the root