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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:chronic obstructive pulmonary disease
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Accession:DOID:3083 term browser browse the term
Definition:An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both. (DO)
Synonyms:exact_synonym: COAD;   COLD;   COPD;   Chronic Airflow Obstruction;   Chronic Airflow Obstructions;   Chronic Obstructive Airway Disease;   Chronic Obstructive Lung Disease
 narrow_synonym: CHRONIC OBSTRUCTIVE PULMONARY DISEASE, BIOMASS RELATED;   COPD, severe early-onset;   Chronic Obstructive Pulmonary Disease, Severe Early-Onset;   PULMONARY DISEASE, CHRONIC OBSTRUCTIVE, RATE OF DECLINE OF LUNG FUNCTION IN
 related_synonym: ANTICHYMOTRYPSIN BONN 1;   HMOX1-RELATED CONDITION;   chronic obstructive pulmonary disease, susceptibility to
 primary_id: MESH:C564641;   MESH:D029424
 alt_id: DOID:9005540;   MIM:606963
 xref: EFO:0000341;   ICD10CM:J44.9;   NCI:C3199
For additional species annotation, visit the Alliance of Genome Resources.

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chronic obstructive pulmonary disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) severity ISO mRNA:decreased expression:respiratory epithelial cell
DNA:SNPs: :rs212093, rs4148382 (human)		 RGD PMID:12930913 PMID:20487524 RGD:5128824 RGD:5128827 NCBI chrNW_004936501:3,400,971...3,467,061
Ensembl chrNW_004936501:3,401,285...3,470,460 		JBrowse link
G Adam33 ADAM metallopeptidase domain 33 susceptibility
no_association		 ISO DNA:polymorphisms: :multiple (human)
DNA:polymorphisms (human)		 RGD PMID:19284602 PMID:20003279 PMID:20156753 RGD:4145357 RGD:4145358 RGD:4145361 NCBI chrNW_004936485:15,005,329...15,018,063
Ensembl chrNW_004936485:15,007,485...15,017,497 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 ISO protein:increased expression:pulmonary artery RGD PMID:36522710 RGD:401850545 NCBI chrNW_004936710:2,301,470...2,388,533
Ensembl chrNW_004936710:2,301,730...2,387,695 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing disease_progression ISO associated with Metabolic Syndrome X;protein:decreased expression:serum RGD PMID:21179920 PMID:22207678 RGD:5686379 RGD:5686825 NCBI chrNW_004936578:3,168,599...3,179,369
Ensembl chrNW_004936578:3,168,331...3,171,928 		JBrowse link
G Adora2a adenosine A2a receptor ISO RGD PMID:16339780 RGD:4890385 NCBI chrNW_004936619:597,970...618,564
Ensembl chrNW_004936619:608,441...616,779 		JBrowse link
G Adrb1 adrenoceptor beta 1 ISO ClinVar Annotator: match by term: Pulmonary disease, chronic obstructive, susceptibility to ClinVar PMID:10212248 PMID:12374873 PMID:16844790 PMID:17496726 NCBI chrNW_004936486:4,400,467...4,401,588
Ensembl chrNW_004936486:4,399,915...4,403,149 		JBrowse link
G Adrb2 adrenoceptor beta 2 no_association
severity
disease_progression		 ISO DNA:polymorphism: :p.Q27E (human)
DNA:SNP: :p.R16G (human)
protein:decreased expression:blood, sputum, mononuclear cell
DNA:SNPs: :p.R16G, p.Q27E (human)
DNA:SNPs: :rs1042717, rs1042718 (human)		 RGD PMID:11527135 PMID:18667995 PMID:18789663 PMID:19080468 PMID:19293197 More... RGD:4140935 RGD:4144899 RGD:4145080 RGD:4145082 RGD:4145086 RGD:4145093 RGD:4145095 RGD:5129114 NCBI chrNW_004936504:5,985,407...5,987,453
Ensembl chrNW_004936504:5,985,960...5,987,210 		JBrowse link
G Ager advanced glycosylation end-product specific receptor ISO ClinVar Annotator: match by term: COPD, severe early onset ClinVar NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147 		JBrowse link
G Ang angiogenin ISO protein:increased expression:sputum RGD PMID:21916917 RGD:6892708 NCBI chrNW_004936880:39,372...40,070 JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 ISO ClinVar Annotator: match by term: Pulmonary disease, chronic obstructive, susceptibility to ClinVar NCBI chrNW_004936483:20,041,712...20,218,853
Ensembl chrNW_004936483:20,041,657...20,218,965 		JBrowse link
G Bambi BMP and activin membrane bound inhibitor ISO mRNA:increased expression:CD4+ T : RGD PMID:27549738 RGD:14390164 NCBI chrNW_004936613:3,098,549...3,103,868
Ensembl chrNW_004936613:3,098,159...3,103,868 		JBrowse link
G Bcl2l1 BCL2 like 1 ISO mRNA:increased expression:peripheral blood, neutrophil (human) RGD PMID:22686245 RGD:11353864 NCBI chrNW_004936485:18,654,046...18,707,324 JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO RGD PMID:16600946 RGD:4890451 NCBI chrNW_004936604:548,844...551,031
Ensembl chrNW_004936604:548,847...549,956 		JBrowse link
G Bmal2 basic helix-loop-helix ARNT like 2 ISO ClinVar Annotator: match by term: Pulmonary disease, chronic obstructive, susceptibility to ClinVar NCBI chrNW_004936548:181,793...241,050
Ensembl chrNW_004936548:182,075...225,856 		JBrowse link
G Bnip3 BCL2 interacting protein 3 treatment ISO RGD PMID:25888379 RGD:11561985 NCBI chrNW_004936486:18,449,371...18,460,435
Ensembl chrNW_004936486:18,448,494...18,455,927 		JBrowse link
G C3 complement C3 ISO protein:increased expression:lung RGD PMID:17975205 RGD:5129504 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G C5 complement C5 severity ISO protein:increased expression:sputum RGD PMID:20500690 RGD:5129705 NCBI chrNW_004936487:9,391,774...9,474,168
Ensembl chrNW_004936487:9,391,804...9,474,159 		JBrowse link
G C5ar1 complement C5a receptor 1 ISO protein:increased expression:lung, mast cell RGD PMID:19926870 RGD:5130165 NCBI chrNW_004936664:1,026,216...1,033,438
Ensembl chrNW_004936664:1,032,304...1,033,374 		JBrowse link
G Casp3 caspase 3 treatment ISO RGD PMID:28496315 RGD:13782303 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Casp8 caspase 8 treatment ISO RGD PMID:28496315 RGD:13782303 NCBI chrNW_004936726:554,627...596,334
Ensembl chrNW_004936726:554,758...595,922 		JBrowse link
G Cat catalase ISO RGD PMID:20080081 RGD:4293707 NCBI chrNW_004936533:3,601,270...3,637,128
Ensembl chrNW_004936533:3,600,955...3,637,422 		JBrowse link
G Ccl1 C-C motif chemokine ligand 1 severity ISO DNA:SNP:enhancer:rs2282691 (human) RGD PMID:16864713 RGD:4891410 NCBI chrNW_004936538:781,687...784,199
Ensembl chrNW_004936538:781,687...784,199 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 ISO mRNA, protein:increased expression:respiratory system mucosa, respiratory system fluid/secretion RGD PMID:18684970 RGD:4145489 NCBI chrNW_004936475:9,475,013...9,476,326
Ensembl chrNW_004936475:9,474,961...9,476,398 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 ISO mRNA, protein:increased expression:respiratory system mucosa, respiratory system fluid/secretion RGD PMID:18684970 RGD:4145489 NCBI chrNW_004936475:9,432,505...9,436,240
Ensembl chrNW_004936475:9,432,505...9,436,240 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO mRNA, protein:increased expression:lung, bronchial epithelium, submucosa (human) RGD PMID:19703829 RGD:4891477 NCBI chrNW_004936490:253,279...259,947
Ensembl chrNW_004936490:253,034...259,965 		JBrowse link
G Ccl8 C-C motif chemokine ligand 8 ISO RGD PMID:20970515 RGD:5131087 NCBI chrNW_004936538:805,273...806,715
Ensembl chrNW_004936538:805,259...806,695 		JBrowse link
G Ccn2 cellular communication network factor 2 ISO mRNA, protein:increased expression:lung (rat) RGD PMID:19659652 RGD:2314483 NCBI chrNW_004936560:42,561...45,748
Ensembl chrNW_004936560:42,537...45,807 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 ISO protein:increased expression:respiratory system fluid/secretion, neutrophil RGD PMID:19017998 RGD:4145632 NCBI chrNW_004936596:223,660...224,739
Ensembl chrNW_004936596:223,660...224,739 		JBrowse link
G Cd28 CD28 molecule ISO CD28 null allele is increased in COPD RGD PMID:18057064 PMID:19220836 RGD:5131618 RGD:5131620 NCBI chrNW_004936631:335,411...363,407
Ensembl chrNW_004936631:335,411...363,407 		JBrowse link
G Cd40 CD40 molecule severity ISO RGD PMID:20699612 RGD:5490968 NCBI chrNW_004936514:6,936,915...6,947,246
Ensembl chrNW_004936514:6,936,572...6,947,280 		JBrowse link
G Cd80 CD80 molecule ISO RGD PMID:19729666 RGD:4892292 NCBI chrNW_004936536:6,462,080...6,483,450 JBrowse link
G Cd86 CD86 molecule severity
susceptibility		 ISO protein:increased expression:lung, myeloid dendritic cell (human)
DNA:polymorphism:cds:g.1057G>A rs1129055 (human)		 RGD PMID:19729666 PMID:20732370 RGD:4891504 RGD:4892292 NCBI chrNW_004936536:8,414,491...8,481,712 JBrowse link
G Cd8a CD8 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:17950725 NCBI chrNW_004936712:885,301...891,247
Ensembl chrNW_004936712:885,458...890,852 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:35303175 NCBI chrNW_004936476:22,717,308...22,725,127
Ensembl chrNW_004936476:22,717,260...22,725,182 		JBrowse link
G Cftr CF transmembrane conductance regulator disease_progression ISO DNA:polymorphism:cds:p.M470V(human) RGD PMID:18652532 RGD:4140431 NCBI chrNW_004936589:1,565,933...1,719,208 JBrowse link
G Chi3l1 chitinase 3 like 1 ISO protein:increased secretion:serum (human) RGD PMID:20656949 RGD:4892658 NCBI chrNW_004936567:1,411,080...1,418,332
Ensembl chrNW_004936567:1,411,037...1,418,801 		JBrowse link
G Chrm3 cholinergic receptor muscarinic 3 ISO RGD PMID:19281093 RGD:5133441 NCBI chrNW_004936484:13,953,141...14,373,174
Ensembl chrNW_004936484:13,954,887...13,956,659 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit susceptibility
disease_progression		 ISO DNA:SNP: :rs12910984(human)
associated with smoking; DNA:SNP: :rs1051730(human)
associated with smoking; DNA:SNP::rs1051730(human)
DNA:SNP: :rs6495309(human)		 RGD PMID:22441734 PMID:23056235 PMID:23207642 PMID:26751916 PMID:29993116 RGD:150526806 RGD:150527850 RGD:151347455 RGD:151347536 RGD:151347538 NCBI chrNW_004936471:36,427,598...36,447,903
Ensembl chrNW_004936471:36,427,495...36,457,758 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit susceptibility ISO associated with lung cancer; DNA:SNP::rs16969968 (human)
associated with smoking; DNA:SNP::rs16969968 (human)		 RGD PMID:29993116 PMID:33419953 RGD:150524357 RGD:150526806 NCBI chrNW_004936471:36,451,070...36,492,774
Ensembl chrNW_004936471:36,452,965...36,492,618 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit disease_progression ISO DNA:CNV:: CNV-3956(human) RGD PMID:25407004 RGD:11074492 NCBI chrNW_004937351:32,324...46,871
Ensembl chrNW_004937351:34,921...47,246 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit ISO ClinVar Annotator: match by term: Chronic obstructive pulmonary disease ClinVar NCBI chrNW_004936471:36,408,471...36,425,571
Ensembl chrNW_004936471:36,408,447...36,426,021 		JBrowse link
G Clca1 chloride channel accessory 1 severity ISO DNA:SNPs: :multiple (human)
mRNA:increased expression:bronchus		 RGD PMID:14985398 PMID:17637221 RGD:1331524 RGD:4145655 NCBI chrNW_004936865:155,284...188,988 JBrowse link
G Col1a1 collagen type I alpha 1 chain ISO RGD PMID:15469929 RGD:5131854 NCBI chrNW_004936490:11,448,552...11,465,836
Ensembl chrNW_004936490:11,448,654...11,464,444 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 treatment ISO DNA:SNP:intron: (rs242941) (human) RGD PMID:19210659 RGD:11097322 NCBI chrNW_004936541:2,288,847...2,333,129
Ensembl chrNW_004936541:2,288,841...2,331,689 		JBrowse link
G Crp C-reactive protein severity ISO protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
protein:increased expression:serum 		RGD
CTD		 PMID:21468168 PMID:21506665 PMID:29329563 RGD:5131278 RGD:5131279 NCBI chrNW_004936740:885,855...888,854
Ensembl chrNW_004936740:883,272...890,606 		JBrowse link
G Csf2 colony stimulating factor 2 ISO protein:increased expression:sputum RGD PMID:19213775 RGD:5131476 NCBI chrNW_004936647:3,081,896...3,083,864
Ensembl chrNW_004936647:3,081,896...3,083,864 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 susceptibility ISO DNA:SNP: :-318C>T (rs5742909) (human) RGD PMID:20732370 PMID:21129004 RGD:4891499 RGD:4891504 NCBI chrNW_004936631:484,356...489,643
Ensembl chrNW_004936631:484,356...489,643 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO protein:increased expression:sputum RGD PMID:17925429 RGD:5135436 NCBI chrNW_004936676:60,869...63,028
Ensembl chrNW_004936676:60,621...63,106 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO protein:increased expression:sputum RGD PMID:17925429 RGD:5135436 NCBI chrNW_004936676:72,383...73,697
Ensembl chrNW_004936676:71,667...73,738 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:sputum RGD PMID:17925429 PMID:19229703 RGD:4892070 RGD:5135436 NCBI chrNW_004936676:33,580...40,323
Ensembl chrNW_004936676:32,128...40,329 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 disease_progression ISO protein:increased expression:respiratory system fluid/secretion, neutrophil RGD PMID:19017998 PMID:19218194 RGD:4145632 RGD:5135435 NCBI chrNW_004936762:66,636...69,694
Ensembl chrNW_004936762:66,636...69,373 		JBrowse link
G Ddit3 DNA damage inducible transcript 3 treatment ISO RGD PMID:24694971 RGD:13782182 NCBI chrNW_004936646:1,665,019...1,669,212 JBrowse link
G Defb1 defensin beta 1 no_association
susceptibility		 ISO DNA:SNPs: :multiple (human)
DNA:polymorphism: :668C>G (human)
DNA:polymorphism (human)		 RGD PMID:11829455 PMID:15569478 PMID:16700921 RGD:1331523 RGD:4892251 RGD:4892257 NCBI chrNW_004936615:4,780,229...4,790,516 JBrowse link
G Dsp desmoplakin ISO ClinVar Annotator: match by term: Chronic obstructive pulmonary disease ClinVar NCBI chrNW_004936534:5,029,008...5,076,467
Ensembl chrNW_004936534:5,028,911...5,077,199 		JBrowse link
G Edn1 endothelin 1 ISO DNA:insertion, transversion:5' utr, exon:c.138_139insA, p.K198N (human)
protein:increased expression:sputum (human)		 RGD PMID:10445603 PMID:20707291 RGD:4144868 RGD:4145062 NCBI chrNW_004936534:885,489...892,292
Ensembl chrNW_004936534:885,287...891,772 		JBrowse link
G Eefsec eukaryotic elongation factor, selenocysteine-tRNA specific ISO CTD Direct Evidence: marker/mechanism CTD PMID:28166215 NCBI chrNW_004936798:448,114...512,234
Ensembl chrNW_004936798:448,105...512,256 		JBrowse link
G Egfr epidermal growth factor receptor ISO protein:increased expression:bronchial epithelium (human) RGD PMID:16393673 PMID:22732689 RGD:5131627 RGD:7204496 NCBI chrNW_004936678:365,005...560,546
Ensembl chrNW_004936678:365,834...436,528 		JBrowse link
G Egr1 early growth response 1 ISO associated with Tobacco Use Disorder
associated with Tobacco Use Disorder;mRNA:increased expression:lung (human)		 RGD PMID:15469929 PMID:20417178 RGD:5131854 RGD:5131878 NCBI chrNW_004936531:7,625,956...7,629,041
Ensembl chrNW_004936531:7,625,892...7,629,749 		JBrowse link
G Eln elastin ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:16081882 PMID:25106431 RGD:1580326 NCBI chrNW_004936543:3,135,169...3,165,023 JBrowse link
G Ephx1 epoxide hydrolase 1 no_association
susceptibility		 ISO DNA:SNPs: :multiple (human)
CTD Direct Evidence: marker/mechanism
DNA:SNP:exon:p.H139R (rs2234922) (human)
DNA:SNPs:exons:p.Y113H (rs1051740), p.H139R (rs2234922) (human)
DNA:polymorphism		 RGD
CTD		 PMID:9288046 PMID:17564249 PMID:18614560 PMID:18811882 PMID:20932192 RGD:1601065 RGD:4889120 RGD:4889121 RGD:4889122 RGD:4889123 NCBI chrNW_004936526:2,589,254...2,652,831
Ensembl chrNW_004936526:2,614,059...2,653,286 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO protein:increased expression:lung RGD PMID:17908459 RGD:2289953 NCBI chrNW_004936646:497,783...515,247
Ensembl chrNW_004936646:498,749...513,297 		JBrowse link
G F2 coagulation factor II, thrombin severity ISO RGD PMID:21660493 RGD:5147752 NCBI chrNW_004936562:2,371,725...2,388,617
Ensembl chrNW_004936562:2,372,044...2,388,650 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO RGD PMID:21245013 RGD:4892586 NCBI chrNW_004936549:142,281...153,575
Ensembl chrNW_004936549:141,512...153,602 		JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 ISO RGD PMID:29208459 RGD:13792601 NCBI chrNW_004936512:7,544,047...7,575,922
Ensembl chrNW_004936512:7,544,003...7,576,315 		JBrowse link
G Fam13a family with sequence similarity 13 member A susceptibility ISO ClinVar Annotator: match by term: Chronic obstructive pulmonary disease
DNA:SNP: :rs7671167 (human)		 ClinVar
RGD		 PMID:25928290 RGD:11552597 NCBI chrNW_004936685:1,174,072...1,358,441
Ensembl chrNW_004936685:1,171,584...1,501,074 		JBrowse link
G Fas Fas cell surface death receptor ISO RGD PMID:29208459 RGD:13792601 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Faslg Fas ligand ISO RGD PMID:29208459 RGD:13792601 NCBI chrNW_004936481:14,789,547...14,795,780 JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 ISO protein:increased expression:lung RGD PMID:15681497 RGD:5684420 NCBI chrNW_004936472:23,442,946...23,617,523
Ensembl chrNW_004936472:23,440,088...23,617,041 		JBrowse link
G Foxo3 forkhead box O3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23099361 NCBI chrNW_004936564:4,788,036...4,907,600
Ensembl chrNW_004936564:4,787,992...4,903,837 		JBrowse link
G Gc GC vitamin D binding protein ISO ClinVar Annotator: match by term: Chronic obstructive pulmonary disease ClinVar PMID:28492532 NCBI chrNW_004936598:3,220,029...3,256,091
Ensembl chrNW_004936598:3,219,991...3,261,629 		JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 susceptibility ISO DNA:SNP: :rs8099939 RGD PMID:28900078 RGD:401900295 NCBI chrNW_004936706:410,806...469,000
Ensembl chrNW_004936706:410,938...464,714 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B susceptibility ISO DNA:SNP: :rs2268132 RGD PMID:28900078 RGD:401900295 NCBI chrNW_004936587:3,406,055...3,806,956
Ensembl chrNW_004936587:3,405,698...3,804,664 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 susceptibility
no_association		 ISO DNA:polymorphism:exon:p.I105V (human)
ClinVar Annotator: match by term: Pulmonary disease, chronic obstructive, susceptibility to		 RGD
ClinVar		 PMID:17439673 PMID:20467983 PMID:25741868 RGD:4140938 RGD:4142514 NCBI chrNW_004936599:2,197,681...2,200,642
Ensembl chrNW_004936599:2,197,634...2,201,050 		JBrowse link
G Gzma granzyme A ISO RGD PMID:20047264 RGD:5135520 NCBI chrNW_004936480:12,641,587...12,649,243
Ensembl chrNW_004936480:12,641,433...12,649,324 		JBrowse link
G Hdac2 histone deacetylase 2 treatment ISO protein:decreased expression:lung:
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:15337792 PMID:18421014 PMID:22732689 PMID:24940433 RGD:7204496 RGD:9590287 NCBI chrNW_004936679:2,448,676...2,474,641
Ensembl chrNW_004936679:2,448,390...2,474,641 		JBrowse link
G Hdac8 histone deacetylase 8 severity ISO mRNA:decreased expression:lung (human) RGD PMID:15888697 RGD:13208820 NCBI chrNW_004936762:1,425,337...1,652,058
Ensembl chrNW_004936762:1,425,335...1,652,063 		JBrowse link
G Hhip hedgehog interacting protein susceptibility ISO DNA:SNP: :rs13118928(human)
ClinVar Annotator: match by term: Chronic obstructive pulmonary disease, biomass related
DNA:SNPs: :rs11100865, rs7654947(human)		 RGD
ClinVar		 PMID:19996190 PMID:25928290 RGD:11552597 RGD:11552598 NCBI chrNW_004936535:4,210,305...4,305,930
Ensembl chrNW_004936535:4,210,305...4,305,930 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:26752192 NCBI chrNW_004936495:5,770,988...5,816,157
Ensembl chrNW_004936495:5,770,669...5,816,157 		JBrowse link
G Hmox1 heme oxygenase 1 treatment
susceptibility
severity		 ISO ClinVar Annotator: match by term: Chronic obstructive pulmonary disease | ClinVar Annotator: match by term: HMOX1-related condition | ClinVar Annotator: match by term: Pulmonary disease, chronic obstructive, severe early-onset
DNA:polymorphism:promoter		 RGD
ClinVar
OMIM		 PMID:9884342 PMID:17203192 PMID:17254481 PMID:20705587 PMID:21088618 More... RGD:10755705 RGD:4145371 RGD:4145372 NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 no_association ISO protein:increased expression:serum (human)
protein:increased expression:bronchial mucosa (human)		 RGD PMID:19350847 PMID:22140545 RGD:5688779 RGD:5688781 NCBI chrNW_004936647:2,087,650...2,133,343
Ensembl chrNW_004936647:2,087,604...2,133,355 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs6313		 CTD
RGD		 PMID:22048642 PMID:28900078 RGD:401900295 NCBI chrNW_004936565:335,238...394,683
Ensembl chrNW_004936565:334,393...394,715 		JBrowse link
G Hykk hydroxylysine kinase ISO ClinVar Annotator: match by term: Chronic obstructive pulmonary disease ClinVar NCBI chrNW_004936471:36,520,182...36,541,087
Ensembl chrNW_004936471:36,517,689...36,541,103 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:decreased expression:airway epithelium (mouse)
mRNA:increased expression:airway epithelial cell (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:18794286 PMID:20395558 PMID:29329563 RGD:4145446 RGD:4145522 NCBI chrNW_004936659:616,570...627,172
Ensembl chrNW_004936659:616,752...627,174 		JBrowse link
G Il12b interleukin 12B ISO DNA:polymorphism: : RGD PMID:19279357 RGD:4145423 NCBI chrNW_004936515:4,056,214...4,066,121
Ensembl chrNW_004936515:4,056,214...4,065,076 		JBrowse link
G Il13 interleukin 13 susceptibility
no_association		 ISO DNA:polymorphism: :c. 1103C>T (human)
DNA:polymorphism:promoter:c.-1055C>T (human)
DNA:polymorphisms:intron1,exon4s: rs2066960, rs20541, rs1295685 (human)
DNA:SNP:promoter:c.-1055 C>T (human)		 RGD PMID:15308043 PMID:15820084 PMID:19796199 PMID:19995275 RGD:4145596 RGD:4145601 RGD:4145668 RGD:4145714 NCBI chrNW_004936647:2,529,933...2,532,503
Ensembl chrNW_004936647:2,530,491...2,532,373 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 ISO DNA:SNP: :rs2250747 (human) RGD PMID:19796199 RGD:4145601 NCBI chrNW_004936479:11,052,077...11,108,915
Ensembl chrNW_004936479:11,050,249...11,108,909 		JBrowse link
G Il16 interleukin 16 ISO protein:increased expression:lung RGD PMID:20079227 RGD:5024924 NCBI chrNW_004936483:19,417,580...19,512,654
Ensembl chrNW_004936483:19,418,086...19,512,639 		JBrowse link
G Il17a interleukin 17A ISO protein:increased expression:lung, bronchioalveolar lavage fluid (rat)
protein:increased expression:respiratory mucosa		 RGD PMID:16200865 PMID:19604272 RGD:4889104 RGD:9068943 NCBI chrNW_004936476:8,621,860...8,625,008
Ensembl chrNW_004936476:8,621,860...8,625,008 		JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:serum
protein:increased expression:sputum, macrophage		 RGD PMID:19208460 PMID:20026745 RGD:4889551 RGD:4889575 NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189 		JBrowse link
G Il18bp interleukin 18 binding protein ISO protein:increased expression:serum RGD PMID:20026745 RGD:4889551 NCBI chrNW_004936498:1,353,569...1,358,312
Ensembl chrNW_004936498:1,355,749...1,361,117 		JBrowse link
G Il1b interleukin 1 beta no_association
severity
susceptibility		 ISO DNA:polymorphism: :-31T>C (human)
DNA:polymorphisms: :-31T>C, 3953T>C (human)
DNA:polymorphisms: :-31T>C, -511C>T (human)
DNA:polymorphisms: :-31T>C, 3954T>C (human)		 RGD PMID:15766560 PMID:17380888 PMID:18364273 PMID:18579366 RGD:4142866 RGD:4142868 RGD:4142873 RGD:4143169 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165 		JBrowse link
G Il1rl1 interleukin 1 receptor like 1 ISO mRNA:increased expression:lung: RGD PMID:19927353 PMID:30952808 RGD:40400740 RGD:5144227 NCBI chrNW_004936713:1,020,969...1,035,012
Ensembl chrNW_004936713:1,021,044...1,035,039 		JBrowse link
G Il1rn interleukin 1 receptor antagonist no_association
susceptibility		 ISO DNA:polymorphism (human)
protein:decreased expression:plasma
DNA:polymorphism:intron (human)		 RGD PMID:18364273 PMID:18579366 PMID:19291375 RGD:4142861 RGD:4142866 RGD:4142868 NCBI chrNW_004936783:1,447,158...1,466,331
Ensembl chrNW_004936783:1,447,106...1,466,340 		JBrowse link
G Il27 interleukin 27 ISO DNA:polymorphisms: :-964A>G, 2905T>G (human) RGD PMID:18554158 RGD:5128484 NCBI chrNW_004936501:11,972,715...11,978,152
Ensembl chrNW_004936501:11,973,385...11,976,583 		JBrowse link
G Il33 interleukin 33 ISO mRNA,protein:increased expression:lung: RGD PMID:30952808 RGD:40400740 NCBI chrNW_004936539:763,755...791,461
Ensembl chrNW_004936539:623,248...791,470 		JBrowse link
G Il5 interleukin 5 ISO protein:increased expression:serum RGD PMID:20858153 RGD:4890939 NCBI chrNW_004936647:2,647,982...2,651,477
Ensembl chrNW_004936647:2,648,241...2,651,430 		JBrowse link
G Il5ra interleukin 5 receptor subunit alpha ISO protein:increased expression:serum RGD PMID:15286446 RGD:5128619 NCBI chrNW_004936577:2,776,608...2,797,303
Ensembl chrNW_004936577:2,776,721...2,797,300 		JBrowse link
G Il6 interleukin 6 ISO protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:20819268 PMID:28864214 PMID:29329563 PMID:31349846 RGD:4143243 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Il9 interleukin 9 ISO protein:increased expression:sputum, macrophage, cytoplasm RGD PMID:15303135 RGD:5128691 NCBI chrNW_004936597:2,983,953...2,986,975
Ensembl chrNW_004936597:2,983,953...2,986,975 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO mRNA, protein:increased expression:lung (mouse) RGD PMID:34331613 RGD:155663371 NCBI chrNW_004936522:3,034,364...3,037,632
Ensembl chrNW_004936522:3,035,346...3,036,350 		JBrowse link
G Kdr kinase insert domain receptor ISO protein:increased expression:lung RGD PMID:15681497 RGD:5684420 NCBI chrNW_004936482:17,537,697...17,581,320
Ensembl chrNW_004936482:17,538,864...17,581,002 		JBrowse link
G Klf5 KLF transcription factor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30639269 NCBI chrNW_004936511:7,806,714...7,824,833
Ensembl chrNW_004936511:7,806,708...7,824,992 		JBrowse link
G Lcn1 lipocalin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28381600 NCBI chrNW_004936669:1,996,399...2,000,130 JBrowse link
G Lep leptin severity ISO DNA:polymorphism:promoter: -2548 G>A (human)
protein:decreased expression:serum
protein:increased expression:plasma		 RGD PMID:20021311 PMID:20854423 PMID:21367591 RGD:5128772 RGD:5128777 RGD:5128778 NCBI chrNW_004936479:15,394,966...15,411,334
Ensembl chrNW_004936479:15,394,966...15,411,334 		JBrowse link
G Lepr leptin receptor disease_progression ISO DNA:SNPs: :
protein:decreased expression:lung		 RGD PMID:19196818 RGD:5128813 NCBI chrNW_004936591:5,771,371...5,846,177
Ensembl chrNW_004936591:5,774,326...5,836,444 		JBrowse link
G LOC101954950 aromatase ISO ClinVar Annotator: match by term: Pulmonary disease, chronic obstructive, susceptibility to ClinVar NCBI chrNW_004936471:13,107,603...13,136,910
Ensembl chrNW_004936471:13,107,603...13,136,910 		JBrowse link
G LOC101955242 cytochrome P450 4B1 ISO ClinVar Annotator: match by term: Pulmonary disease, chronic obstructive, susceptibility to ClinVar NCBI chrNW_004936474:27,705,874...27,782,328
Ensembl chrNW_004936474:27,767,371...27,782,008 		JBrowse link
G LOC101955831 heat shock 70 kDa protein 1 ISO ClinVar Annotator: match by term: Chronic obstructive pulmonary disease ClinVar NCBI chrNW_004936727:1,718,952...1,721,691 JBrowse link
G LOC101956126 heat shock 70 kDa protein 1 ISO ClinVar Annotator: match by term: Chronic obstructive pulmonary disease ClinVar NCBI chrNW_004936727:1,732,323...1,735,128 JBrowse link
G LOC101956412 heat shock 70 kDa protein 1-like ISO ClinVar Annotator: match by term: Chronic obstructive pulmonary disease ClinVar NCBI chrNW_004936727:1,735,880...1,745,231
Ensembl chrNW_004936727:1,736,243...1,745,231 		JBrowse link
G LOC101960095 antileukoproteinase treatment ISO RGD PMID:18375249 RGD:9999419 NCBI chrNW_004936514:7,618,382...7,620,790
Ensembl chrNW_004936514:7,618,261...7,620,912 		JBrowse link
G LOC101961079 cholesterol 24-hydroxylase ISO ClinVar Annotator: match by term: Pulmonary disease, chronic obstructive, susceptibility to ClinVar NCBI chrNW_004936604:3,451,853...3,490,688
Ensembl chrNW_004936604:3,451,842...3,491,159 		JBrowse link
G LOC101963197 HLA class II histocompatibility antigen, DP beta 1 chain ISO RGD PMID:21423603 RGD:5143980 NCBI chrNW_004936476:25,730,800...25,741,089
Ensembl chrNW_004936476:25,730,596...25,741,145 		JBrowse link
G LOC101964975 interleukin-8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15337792 PMID:23099361 PMID:28864214 NCBI chrNW_004936598:1,779,471...1,781,353
Ensembl chrNW_004936598:1,779,471...1,781,353 		JBrowse link
G LOC101967032 cytochrome b-245 light chain susceptibility ISO DNA:polymorphism: :p.H72Y (human)
DNA:polymorphisms: :-930A>G, 242C>T (human)		 RGD PMID:19567155 PMID:20080081 RGD:4293707 RGD:4304108 NCBI chrNW_004936641:1,036,967...1,044,954
Ensembl chrNW_004936641:1,036,967...1,044,991 		JBrowse link
G LOC101968920 eotaxin severity ISO RGD PMID:19925666 RGD:4145389 NCBI chrNW_004936538:835,436...848,907
Ensembl chrNW_004936538:835,859...837,710
Ensembl chrNW_004936538:835,859...837,710 		JBrowse link
G LOC101968921 angiotensin-converting enzyme disease_progression
susceptibility		 ISO DNA:polymorphism (human) RGD PMID:19493329 PMID:20096799 PMID:20156752 RGD:4140480 RGD:4140487 RGD:4140912 NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177 		JBrowse link
G LOC101969148 cytochrome P450 1A1 susceptibility
severity
no_association		 ISO DNA:polymorphisms: :p.I462V, 3801T>C (human)
DNA:polymorphism (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphisms: :2455A>G, 3801T>C (human)		 RGD
CTD		 PMID:18389617 PMID:19022366 PMID:19507017 PMID:20080081 RGD:4293707 RGD:4892045 RGD:4892071 NCBI chrNW_004936471:33,682,730...33,688,332
Ensembl chrNW_004936471:33,682,730...33,688,332 		JBrowse link
G LOC101969421 cytochrome P450 1A2 susceptibility ISO DNA:polymorphisms: :-3860G>A (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:20080081 PMID:20797314 RGD:4293707 NCBI chrNW_004936471:33,704,616...33,709,455
Ensembl chrNW_004936471:33,703,792...33,709,484 		JBrowse link
G LOC101972957 vitamin D 25-hydroxylase ISO ClinVar Annotator: match by term: Pulmonary disease, chronic obstructive, susceptibility to ClinVar PMID:25741868 PMID:28492532 NCBI chrNW_004936528:3,881,630...3,897,613
Ensembl chrNW_004936528:3,881,087...3,900,302 		JBrowse link
G LOC101973029 cytochrome P450 2E1 ISO DNA:polymorphisms: :-1293G>C, 7632T>A, 9893C>G (human) RGD PMID:17442289 RGD:4892219 NCBI chrNW_004936486:19,691,822...19,702,684
Ensembl chrNW_004936486:19,691,822...19,702,102 		JBrowse link
G LOC101973720 rap guanine nucleotide exchange factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22363678 NCBI chrNW_004936512:5,636,197...5,659,606
Ensembl chrNW_004936512:5,636,758...5,659,300
Ensembl chrNW_004936512:5,636,758...5,659,300 		JBrowse link
G LOC101975630 solute carrier family 22 member 4 treatment ISO RGD PMID:32707498 RGD:597538521 NCBI chrNW_004936647:2,825,814...2,874,786
Ensembl chrNW_004936647:2,825,814...2,874,774 		JBrowse link
G LOC101975820 cholesterol side-chain cleavage enzyme, mitochondrial ISO ClinVar Annotator: match by term: Pulmonary disease, chronic obstructive, susceptibility to ClinVar NCBI chrNW_004936471:33,367,810...33,380,764
Ensembl chrNW_004936471:33,367,810...33,380,764 		JBrowse link
G LOC101976500 haptoglobin ISO RGD PMID:21471098 RGD:5144151 NCBI chrNW_004936475:21,841,054...21,845,821 JBrowse link
G Lrp1b LDL receptor related protein 1B susceptibility ISO associated with lung adenocarcinoma;DNA:mutations:multiple: (human) RGD PMID:28522810 RGD:150429784 NCBI chrNW_004936469:35,000,773...36,160,216
Ensembl chrNW_004936469:35,203,594...36,159,283 		JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 severity ISO RGD PMID:20699612 RGD:5490968 NCBI chrNW_004936595:4,762,327...4,828,433
Ensembl chrNW_004936595:4,727,108...4,830,662 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 ISO mRNA, protein:increased expression:lung (mouse) RGD PMID:34331613 RGD:155663371 NCBI chrNW_004936510:1,772,971...1,836,075
Ensembl chrNW_004936510:1,772,971...1,837,765 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 severity ISO mRNA, protein:increased expression:lung (mouse) RGD PMID:20699612 PMID:34331613 RGD:155663371 RGD:5490968 NCBI chrNW_004936728:1,775,746...1,893,895
Ensembl chrNW_004936728:1,775,641...1,893,907 		JBrowse link
G Mcam melanoma cell adhesion molecule ISO RGD PMID:23649916 RGD:7364780 NCBI chrNW_004936542:4,235,914...4,244,981
Ensembl chrNW_004936542:4,237,010...4,244,462 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 ISO ClinVar Annotator: match by term: Pulmonary disease, chronic obstructive, susceptibility to ClinVar NCBI chrNW_004936587:1,270,030...1,287,130
Ensembl chrNW_004936587:1,269,184...1,287,150 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 ISO ClinVar Annotator: match by term: Pulmonary disease, chronic obstructive, susceptibility to ClinVar NCBI chrNW_004936481:19,654,335...19,665,994
Ensembl chrNW_004936481:19,654,441...19,659,291 		JBrowse link
G Mif macrophage migration inhibitory factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:26752192 NCBI chrNW_004936619:1,207,058...1,208,010
Ensembl chrNW_004936619:1,203,746...1,208,442 		JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO ClinVar Annotator: match by term: PULMONARY DISEASE, CHRONIC OBSTRUCTIVE, RATE OF DECLINE OF LUNG FUNCTION IN | ClinVar Annotator: match by term: Pulmonary disease, chronic obstructive, severe early-onset ClinVar PMID:9850057 PMID:11741975 PMID:11875051 PMID:18030675 PMID:25741868 More... NCBI chrNW_004936551:5,167,909...5,175,149
Ensembl chrNW_004936551:5,168,044...5,174,857 		JBrowse link
G Mmp14 matrix metallopeptidase 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19661247 NCBI chrNW_004936722:1,447,189...1,457,632
Ensembl chrNW_004936722:1,447,335...1,457,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment
susceptibility
severity		 ISO protein:increased expression:serum
DNA:polymorphism: :-1562C-->T (human)
DNA:polymorphism:promoter:-1562C-->T (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:18619044 PMID:19299917 PMID:19411568 PMID:20160424 PMID:25842729 RGD:13207319 RGD:5129494 RGD:5129553 RGD:5130149 NCBI chrNW_004936514:7,038,240...7,045,873
Ensembl chrNW_004936514:7,037,639...7,045,793 		JBrowse link
G Mpo myeloperoxidase severity ISO protein:increased expression:serum
protein:increased activity:plasma		 RGD PMID:10917466 PMID:19491038 RGD:5130993 RGD:5130997 NCBI chrNW_004936490:4,809,773...4,819,070
Ensembl chrNW_004936490:4,809,631...4,819,070 		JBrowse link
G Mtcl1 microtubule crosslinking factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28166215 NCBI chrNW_004936670:2,388,839...2,516,758
Ensembl chrNW_004936670:2,388,908...2,516,875 		JBrowse link
G Muc1 mucin 1, cell surface associated ISO protein:increased expression:sputum (human) RGD PMID:21474912 RGD:5131160 NCBI chrNW_004936580:4,691,870...4,694,092 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming treatment ISO mRNA, protein:increased expression:lung
protein:increased expression:bronchi		 RGD PMID:17637221 PMID:19723147 PMID:22282955 RGD:4145655 RGD:5131190 RGD:7349406 NCBI chrNW_004936816:129,926...159,396 JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming ISO protein:increased expression:sputum RGD PMID:18776153 RGD:5131169 NCBI chrNW_004936816:174,943...209,241 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 ISO protein:decreased expression:lung
protein:increased expression:lung		 RGD PMID:18556627 PMID:22737924 RGD:10412732 RGD:5134980 NCBI chrNW_004936509:6,589,967...6,621,171
Ensembl chrNW_004936509:6,590,630...6,620,262 		JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 severity ISO DNA:SNP:intron: (rs1077861) (human) RGD PMID:21943069 RGD:5508720 NCBI chrNW_004936475:3,708,069...3,742,845
Ensembl chrNW_004936475:3,713,362...3,745,982 		JBrowse link
G Nos1 nitric oxide synthase 1 severity ISO protein:increased expression:skeletal muscle
mRNA, protein:increased expression:lung		 RGD PMID:12816735 PMID:19797159 RGD:5132607 RGD:5132628 NCBI chrNW_004936558:5,162,471...5,302,488
Ensembl chrNW_004936558:5,233,459...5,301,414 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:lung		 CTD
RGD		 PMID:12797490 PMID:21843929 RGD:4891444 NCBI chrNW_004936538:4,052,277...4,097,051
Ensembl chrNW_004936538:4,052,448...4,097,051 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21843929 NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 susceptibility
treatment		 ISO DNA:polymorphisms: :465C>T, 609C>T (human)
protein, mRNA:decreased expression:lung		 RGD PMID:18556627 PMID:19705749 PMID:28790194 RGD:13439712 RGD:5133267 RGD:5134980 NCBI chrNW_004936475:19,771,384...19,785,034
Ensembl chrNW_004936475:19,769,488...19,785,311 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3 group C member 1 ISO protein:decreased expression:lung, lymphocyte RGD PMID:9926163 PMID:20450542 RGD:4892318 RGD:4892564 NCBI chrNW_004936504:10,960,069...11,056,834
Ensembl chrNW_004936504:10,959,192...11,056,856 		JBrowse link
G Ntf3 neurotrophin 3 ISO mRNA:decreased expression:bronchus RGD PMID:15843147 RGD:4891120 NCBI chrNW_004936709:2,163,510...2,223,429
Ensembl chrNW_004936709:2,163,334...2,223,552 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 ISO protein:increased expression:bronchiolar epithelial cell RGD PMID:21429417 RGD:5684530 NCBI chrNW_004936580:6,002,168...6,021,690
Ensembl chrNW_004936580:6,002,120...6,021,709 		JBrowse link
G Pde3b phosphodiesterase 3B ISO ClinVar Annotator: match by term: Pulmonary disease, chronic obstructive, susceptibility to ClinVar PMID:25741868 PMID:28492532 NCBI chrNW_004936528:3,922,436...4,087,991
Ensembl chrNW_004936528:3,923,379...4,087,188 		JBrowse link
G Plau plasminogen activator, urokinase severity ISO protein:increased expression:sputum, neutrophil RGD PMID:17651644 PMID:20624254 RGD:6483803 RGD:6484146 NCBI chrNW_004936521:5,238,128...5,243,829
Ensembl chrNW_004936521:5,238,093...5,243,877 		JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO protein:increased expression:bronchus RGD PMID:17651644 RGD:6484146 NCBI chrNW_004936706:840,968...855,552 JBrowse link
G Pon1 paraoxonase 1 ISO protein:decreased activity:serum (human) RGD PMID:16380766 RGD:8547571 NCBI chrNW_004936585:4,954,871...4,979,560
Ensembl chrNW_004936585:4,954,869...4,979,591 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO RGD PMID:20732852 RGD:6484530 NCBI chrNW_004936477:4,881,230...5,488,208
Ensembl chrNW_004936477:5,199,881...5,488,226 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO DNA:polymorphism: :g.-765G>C (human)
protein:increased expression:sputum		 RGD PMID:15949313 PMID:21655952 RGD:5135277 RGD:5143926 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO mRNA, protein:increased expression:lung (mouse) RGD PMID:34331613 RGD:155663371 NCBI chrNW_004936599:3,800,142...3,810,583
Ensembl chrNW_004936599:3,801,636...3,809,813 		JBrowse link
G Rnasel ribonuclease L ISO RGD PMID:23913960 RGD:40902622 NCBI chrNW_004936481:7,165,400...7,177,342
Ensembl chrNW_004936481:7,165,353...7,177,538 		JBrowse link
G Rtel1 regulator of telomere elongation helicase 1 ameliorates ISO DNA:SNP:cds:rs4809324 (human) RGD PMID:28360516 RGD:152985694 NCBI chrNW_004936514:10,920,979...10,954,483
Ensembl chrNW_004936514:10,922,322...10,954,402 		JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 ISO ClinVar Annotator: match by term: Chronic obstructive pulmonary disease ClinVar NCBI chrNW_004936581:798,738...801,614
Ensembl chrNW_004936581:798,739...801,633 		JBrowse link
G Selp selectin P severity ISO protein:increased expression:plasma RGD PMID:20646456 RGD:6478682 NCBI chrNW_004936481:17,076,660...17,112,501
Ensembl chrNW_004936481:17,076,536...17,107,963 		JBrowse link
G Serpina3 serpin family A member 3 susceptibility ISO DNA:polymorphism:exon:p.A-15T (human)
ClinVar Annotator: match by term: ANTICHYMOTRYPSIN BONN 1		 RGD
ClinVar		 PMID:1351206 PMID:8102759 PMID:8244391 PMID:10849024 PMID:25741868 RGD:5147441 NCBI chrNW_004936846:174,411...182,053
Ensembl chrNW_004936846:174,233...182,203 		JBrowse link
G Serpine1 serpin family E member 1 ISO protein:increased expression:bronchus RGD PMID:11929177 PMID:17651644 RGD:4144041 RGD:6484146 NCBI chrNW_004936543:1,032,543...1,040,956
Ensembl chrNW_004936543:1,032,794...1,039,123 		JBrowse link
G Sftpb surfactant protein B susceptibility
severity		 ISO DNA:polymorphism: :1580C>T (human)
DNA:SNPs: :multiple (human)
DNA:SNP: :p.T131I (rs1130866) (human)		 RGD PMID:11589345 PMID:15315329 PMID:15817713 PMID:18550614 RGD:4143290 RGD:4143396 RGD:4143402 RGD:4143423 NCBI chrNW_004936712:1,614,979...1,621,207
Ensembl chrNW_004936712:1,614,979...1,622,466 		JBrowse link
G Sftpc surfactant protein C disease_progression ISO DNA:polymorphism: :186A>G (human) RGD PMID:18038590 RGD:4144115 NCBI chrNW_004936555:5,966,610...5,982,083
Ensembl chrNW_004936555:5,979,417...5,982,011 		JBrowse link
G Sftpd surfactant protein D severity
susceptibility		 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
DNA:SNP: :p.A160T (human)
DNA:SNPs: :multiple (human)		 RGD
CTD		 PMID:18310480 PMID:19797132 PMID:20075511 PMID:20448057 PMID:28166215 RGD:4143281 RGD:4143487 RGD:4143492 RGD:4143501 NCBI chrNW_004936716:60,754...73,010
Ensembl chrNW_004936716:60,656...73,099 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 treatment ISO RGD PMID:32707498 RGD:597538521 NCBI chrNW_004936647:2,774,063...2,798,585
Ensembl chrNW_004936647:2,773,768...2,798,511 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 susceptibility ISO DNA:SNP: :rs2020936 (human) RGD PMID:20981038 RGD:4889426 NCBI chrNW_004936538:6,205,268...6,239,062
Ensembl chrNW_004936538:6,205,251...6,239,083 		JBrowse link
G Smad4 SMAD family member 4 treatment ISO RGD PMID:18375249 RGD:9999419 NCBI chrNW_004936497:12,242,869...12,278,012
Ensembl chrNW_004936497:12,249,140...12,278,123 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 ISO protein:increased expression:lung: RGD PMID:20448054 RGD:10041059 NCBI chrNW_004936475:18,667,563...18,755,132
Ensembl chrNW_004936475:18,671,428...18,755,208 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO protein:increased expression:lung RGD PMID:24321062 RGD:8661725 NCBI chrNW_004936506:7,091,982...7,185,938
Ensembl chrNW_004936506:7,095,009...7,184,689 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 ISO associated with Haemophilus Infections;mRNA, protein:increased expression:lung (mouse) RGD PMID:29421524 RGD:39128228 NCBI chrNW_004936531:8,555,966...8,562,829
Ensembl chrNW_004936531:8,555,637...8,562,885 		JBrowse link
G Tab2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 ISO mRNA, protein:increased expression:lung (mouse) RGD PMID:34331613 RGD:155663371 NCBI chrNW_004936489:2,371,953...2,421,882
Ensembl chrNW_004936489:2,372,216...2,424,515 		JBrowse link
G Tert telomerase reverse transcriptase ISO ClinVar Annotator: match by term: Chronic obstructive pulmonary disease ClinVar PMID:25346280 PMID:25741868 PMID:28492532 PMID:30523342 PMID:30791107 NCBI chrNW_004936815:468,987...492,666
Ensembl chrNW_004936815:469,020...491,697 		JBrowse link
G Tgfb1 transforming growth factor beta 1 no_association
susceptibility		 ISO DNA:polymorphisms: :509C>T, 869T>C (human)
protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism
DNA:SNP:exon:869T>C (human)		 RGD
CTD		 PMID:16365456 PMID:18269849 PMID:19186046 PMID:20193474 PMID:31349846 RGD:4145115 RGD:4145140 RGD:4145292 NCBI chrNW_004936661:3,742,080...3,758,266
Ensembl chrNW_004936661:3,742,066...3,758,272 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 treatment ISO RGD PMID:25842729 RGD:13207319 NCBI chrNW_004936502:13,345,936...13,350,170
Ensembl chrNW_004936502:13,345,832...13,350,248 		JBrowse link
G Tlr4 toll like receptor 4 susceptibility ISO DNA:polymorphism:blood cells
ClinVar Annotator: match by term: Pulmonary disease, chronic obstructive, severe early-onset		 RGD
ClinVar		 PMID:10835634 PMID:12124407 PMID:15547160 PMID:15829498 PMID:16879199 More... RGD:4144119 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
G Tnf tumor necrosis factor disease_progression
no_association		 ISO DNA:polymorphism: :c. 489G>A (human)
CTD Direct Evidence: marker/mechanism
DNA;polymorphism: :rs361525 (human)
DNA:SNPs:promoter
DNA:polymorphism:promoter
protein:increased expression:sputum
protein:increased expression:serum
DNA:SNP:promoter:c.-308 G>A (human)		 RGD
CTD		 PMID:8564092 PMID:11179116 PMID:12537602 PMID:15337792 PMID:15820084 More... RGD:4143270 RGD:4143272 RGD:4143273 RGD:4143391 RGD:4143421 RGD:4143424 RGD:4145714 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A severity ISO protein:increased expression:plasma (human) RGD PMID:19643942 RGD:5131203 NCBI chrNW_004936709:1,407,327...1,421,448
Ensembl chrNW_004936709:1,407,278...1,421,921 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B severity ISO protein:increased expression:sputum (human) RGD PMID:21037022 RGD:5131154 NCBI chrNW_004936474:908,414...935,765
Ensembl chrNW_004936474:908,485...934,177 		JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29984229 NCBI chrNW_004936474:814,510...889,851 JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29984229 NCBI chrNW_004936487:4,057,637...4,081,207
Ensembl chrNW_004936487:4,057,643...4,081,207 		JBrowse link
G Tnnt2 troponin T2, cardiac type ISO CTD Direct Evidence: marker/mechanism CTD PMID:18068611 NCBI chrNW_004936567:3,052,167...3,069,077
Ensembl chrNW_004936567:3,056,845...3,068,887 		JBrowse link
G Tollip toll interacting protein ISO ClinVar Annotator: match by term: Chronic obstructive pulmonary disease ClinVar NCBI chrNW_004936816:216,542...245,545
Ensembl chrNW_004936816:216,546...245,606 		JBrowse link
G Tp53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17274270 NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425 		JBrowse link
G Trpv4 transient receptor potential cation channel subfamily V member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21245013 NCBI chrNW_004936769:1,424,526...1,447,547
Ensembl chrNW_004936769:1,424,549...1,447,516 		JBrowse link
G Vdr vitamin D receptor ISO ClinVar Annotator: match by term: Chronic obstructive pulmonary disease ClinVar NCBI chrNW_004936512:5,741,836...5,800,999
Ensembl chrNW_004936512:5,740,748...5,801,109 		JBrowse link
G Vegfa vascular endothelial growth factor A treatment ISO protein:increased expression:lung RGD PMID:15681497 PMID:20705587 RGD:10755705 RGD:5684420 NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 susceptibility ISO DNA:SNPs:multiple (human) RGD PMID:20463177 RGD:8698653 NCBI chrNW_004936586:1,055,478...1,137,924
Ensembl chrNW_004936586:1,055,335...1,137,984 		JBrowse link
Chronic Bronchitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator susceptibility ISO associated with pulmonary disease chronic obstructive; DNA:missense mutation:exon:p.R75Q(human)
DNA:deletion: :F508del(human)		 RGD PMID:10767489 PMID:15463907 RGD:4140475 RGD:4140484 NCBI chrNW_004936589:1,565,933...1,719,208 JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 ISO DNA:SNPs: :multiple (human) RGD PMID:19386687 RGD:4891509 NCBI chrNW_004936631:484,356...489,643
Ensembl chrNW_004936631:484,356...489,643 		JBrowse link
G Edn1 endothelin 1 ISO Chronic Allergic Airway Inflammation; protein:increased secretion:bronchoalveolar lavage (mouse) RGD PMID:18631350 RGD:4145074 NCBI chrNW_004936534:885,489...892,292
Ensembl chrNW_004936534:885,287...891,772 		JBrowse link
G Gc GC vitamin D binding protein susceptibility ISO RGD PMID:12096683 RGD:5129516 NCBI chrNW_004936598:3,220,029...3,256,091
Ensembl chrNW_004936598:3,219,991...3,261,629 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:bronchial epithelium (rat) RGD PMID:19507274 RGD:2308951 NCBI chrNW_004936659:616,570...627,172
Ensembl chrNW_004936659:616,752...627,174 		JBrowse link
G Il10 interleukin 10 ISO protein:decreased expression:lung RGD PMID:19507274 RGD:2308951 NCBI chrNW_004936557:5,834,874...5,838,502
Ensembl chrNW_004936557:5,834,874...5,838,502 		JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:Respiratory Mucosa RGD PMID:14582911 RGD:4759835 NCBI chrNW_004936647:2,529,933...2,532,503
Ensembl chrNW_004936647:2,530,491...2,532,373 		JBrowse link
G Il15 interleukin 15 ISO mRNA, protein:increased expression:lung RGD PMID:11742275 RGD:4990461 NCBI chrNW_004936535:6,344,348...6,358,803
Ensembl chrNW_004936535:6,344,395...6,350,197 		JBrowse link
G LOC101968920 eotaxin ISO RGD PMID:11991282 RGD:4145442 NCBI chrNW_004936538:835,436...848,907
Ensembl chrNW_004936538:835,859...837,710
Ensembl chrNW_004936538:835,859...837,710 		JBrowse link
G LOC101969148 cytochrome P450 1A1 susceptibility ISO DNA:polymorphism (human) RGD PMID:15928955 RGD:4142512 NCBI chrNW_004936471:33,682,730...33,688,332
Ensembl chrNW_004936471:33,682,730...33,688,332 		JBrowse link
G LOC101973029 cytochrome P450 2E1 ISO DNA:polymorphism (human) RGD PMID:14593914 RGD:4889126 NCBI chrNW_004936486:19,691,822...19,702,684
Ensembl chrNW_004936486:19,691,822...19,702,102 		JBrowse link
G Mpo myeloperoxidase ISO protein:increased expression:lung RGD PMID:11798689 RGD:5130990 NCBI chrNW_004936490:4,809,773...4,819,070
Ensembl chrNW_004936490:4,809,631...4,819,070 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO RGD PMID:19938219 RGD:4891494 NCBI chrNW_004936538:4,052,277...4,097,051
Ensembl chrNW_004936538:4,052,448...4,097,051 		JBrowse link
G Npy neuropeptide Y ISO CTD Direct Evidence: marker/mechanism CTD PMID:9731035 NCBI chrNW_004936478:1,289,437...1,296,819
Ensembl chrNW_004936478:1,290,505...1,296,874 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19263519 NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673 		JBrowse link
pulmonary emphysema term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO RGD PMID:20935231 RGD:5686887 NCBI chrNW_004936578:3,168,599...3,179,369
Ensembl chrNW_004936578:3,168,331...3,171,928 		JBrowse link
G Ager advanced glycosylation end-product specific receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:30659203 NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147 		JBrowse link
G Bloc1s6 biogenesis of lysosomal organelles complex 1 subunit 6 ISO OMIM:130700 MouseDO NCBI chrNW_004936471:8,209,091...8,226,249
Ensembl chrNW_004936471:8,209,057...8,226,353 		JBrowse link
G Chi3l1 chitinase 3 like 1 ISO RGD PMID:20656949 RGD:4892658 NCBI chrNW_004936567:1,411,080...1,418,332
Ensembl chrNW_004936567:1,411,037...1,418,801 		JBrowse link
G Clptm1l CLPTM1 like severity ISO associated with smoking; DNA:SNP:intron:rs31489(human) RGD PMID:21622582 RGD:150530642 NCBI chrNW_004936815:421,996...445,577
Ensembl chrNW_004936815:428,920...445,750 		JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:19537526 RGD:11039438 NCBI chrNW_004936490:15,142,526...15,146,375
Ensembl chrNW_004936490:15,142,808...15,144,487 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:18772344 RGD:4891888 NCBI chrNW_004936475:9,443,851...9,454,715
Ensembl chrNW_004936475:9,443,733...9,455,062 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO protein:increased expression:lung, lymphocyte RGD PMID:15526056 RGD:4892104 NCBI chrNW_004936676:60,869...63,028
Ensembl chrNW_004936676:60,621...63,106 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:lung, lymphocyte RGD PMID:15526056 RGD:4892104 NCBI chrNW_004936676:33,580...40,323
Ensembl chrNW_004936676:32,128...40,329 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:15526056 RGD:4892104 NCBI chrNW_004936762:66,636...69,694
Ensembl chrNW_004936762:66,636...69,373 		JBrowse link
G Defb1 defensin beta 1 ISO mRNA:decreased expression:lung RGD PMID:18699806 RGD:4892249 NCBI chrNW_004936615:4,780,229...4,790,516 JBrowse link
G Ednra endothelin receptor type A ISO RGD PMID:19897563 RGD:4892307 NCBI chrNW_004936535:1,950,117...2,005,786
Ensembl chrNW_004936535:1,949,941...2,005,910 		JBrowse link
G Egr1 early growth response 1 resistance ISO associated with Tobacco Use Disorder;protein:increased expression:lung, epithelial cell (mouse)
mRNA, protein:increased expression:lung (human)		 RGD PMID:11021835 PMID:16601242 PMID:18830406 RGD:5131853 RGD:5131892 RGD:5131973 NCBI chrNW_004936531:7,625,956...7,629,041
Ensembl chrNW_004936531:7,625,892...7,629,749 		JBrowse link
G Eln elastin ISO CTD Direct Evidence: marker/mechanism CTD PMID:25106431 NCBI chrNW_004936543:3,135,169...3,165,023 JBrowse link
G Ephx1 epoxide hydrolase 1 susceptibility
no_association		 ISO DNA:SNP:exon:p.Y113H (rs1051740) (human)
CTD Direct Evidence: marker/mechanism
DNA:SNPs:exons:p.Y113H (rs1051740), p.H139R (rs2234922) (human)
associated with Pulmonary Disease, Chronic Obstructive;DNA:SNPs (human)		 RGD
CTD		 PMID:9288046 PMID:10853854 PMID:12579334 PMID:20525719 RGD:1601065 RGD:4140935 RGD:4889405 RGD:4889406 NCBI chrNW_004936526:2,589,254...2,652,831
Ensembl chrNW_004936526:2,614,059...2,653,286 		JBrowse link
G Fga fibrinogen alpha chain ISO protein:increased expression:plasma (rat) RGD PMID:20949089 RGD:11040553 NCBI chrNW_004936576:1,322,406...1,329,743 JBrowse link
G Fstl1 follistatin like 1 ISO OMIM:130700 MouseDO NCBI chrNW_004936536:7,132,369...7,186,951
Ensembl chrNW_004936536:7,126,966...7,187,269 		JBrowse link
G Fut8 fucosyltransferase 8 ISO OMIM:130700 MouseDO NCBI chrNW_004936495:9,012,425...9,341,538
Ensembl chrNW_004936495:9,115,938...9,344,068 		JBrowse link
G Gclc glutamate-cysteine ligase catalytic subunit ISO RGD PMID:19879314 RGD:5134681 NCBI chrNW_004936476:7,371,270...7,418,756
Ensembl chrNW_004936476:7,371,149...7,418,958 		JBrowse link
G Gstm3 glutathione S-transferase mu 3 ISO RGD PMID:19723343 RGD:5135041 NCBI chrNW_004936704:1,233,909...1,236,864
Ensembl chrNW_004936704:1,233,780...1,237,329 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO associated with Pulmonary Disease, Chronic Obstructive;DNA:SNP (human) RGD PMID:20525719 RGD:4140935 NCBI chrNW_004936599:2,197,681...2,200,642
Ensembl chrNW_004936599:2,197,634...2,201,050 		JBrowse link
G Hdac2 histone deacetylase 2 treatment ISO mRNA,proetin:increased expression,increased activity,hyperphosphorylation,hypercarbonylation:lung: RGD PMID:23326540 PMID:24040961 RGD:9590245 RGD:9590320 NCBI chrNW_004936679:2,448,676...2,474,641
Ensembl chrNW_004936679:2,448,390...2,474,641 		JBrowse link
G Hhip hedgehog interacting protein ISO DNA:haplotype insufficiency: : RGD PMID:25763110 RGD:11552596 NCBI chrNW_004936535:4,210,305...4,305,930
Ensembl chrNW_004936535:4,210,305...4,305,930 		JBrowse link
G Hmox1 heme oxygenase 1 susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:allele:promoter:L allele of the (GT)n repeat (>30 repeats)		 CTD
RGD		 PMID:10631150 RGD:1601606 NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311 		JBrowse link
G Il13 interleukin 13 ISO RGD PMID:11067861 RGD:4145652 NCBI chrNW_004936647:2,529,933...2,532,503
Ensembl chrNW_004936647:2,530,491...2,532,373 		JBrowse link
G Il17ra interleukin 17 receptor A ISO RGD PMID:21647421 RGD:5144212 NCBI chrNW_004936807:143,165...165,820 JBrowse link
G Il18 interleukin 18 ISO mRNA, protein:increased expression:respiratory system fluid/secretion, macrophage RGD PMID:17400729 PMID:23392573 RGD:4889590 RGD:8655969 NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189 		JBrowse link
G Il1rl1 interleukin 1 receptor like 1 treatment ISO associated with common cold; RGD PMID:30952808 RGD:40400740 NCBI chrNW_004936713:1,020,969...1,035,012
Ensembl chrNW_004936713:1,021,044...1,035,039 		JBrowse link
G Itgb6 integrin subunit beta 6 ISO CTD Direct Evidence: marker/mechanism
OMIM:130700		 RGD
CTD
MouseDO		 PMID:12634787 RGD:737734 NCBI chrNW_004936469:18,581,855...18,650,109
Ensembl chrNW_004936469:18,581,840...18,650,123 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO OMIM:130700 MouseDO NCBI chrNW_004936522:3,034,364...3,037,632
Ensembl chrNW_004936522:3,035,346...3,036,350 		JBrowse link
G Keap1 kelch like ECH associated protein 1 onset ISO protein:increased expression:lung (human) RGD PMID:18559366 PMID:19520915 RGD:5134973 RGD:6893395 NCBI chrNW_004936659:785,059...793,775
Ensembl chrNW_004936659:782,340...793,688 		JBrowse link
G Kl klotho ISO OMIM:130700 MouseDO NCBI chrNW_004936472:27,604,681...27,649,613
Ensembl chrNW_004936472:27,604,517...27,650,086 		JBrowse link
G LOC101961846 neutrophil elastase ISO RGD PMID:12186827 RGD:10450557 NCBI chrNW_004936588:345,678...347,420
Ensembl chrNW_004936588:345,678...347,413 		JBrowse link
G LOC101968920 eotaxin disease_progression ISO associated with Pulmonary Disease, Chronic Obstructive;protein:increased expression:lung RGD PMID:17983873 RGD:4145393 NCBI chrNW_004936538:835,436...848,907
Ensembl chrNW_004936538:835,859...837,710
Ensembl chrNW_004936538:835,859...837,710 		JBrowse link
G Lox lysyl oxidase ISO ClinVar Annotator: match by term: Pulmonary emphysema ClinVar PMID:25741868 PMID:28492532 NCBI chrNW_004936575:2,526,067...2,533,996
Ensembl chrNW_004936575:2,524,342...2,533,559 		JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO DNA:insertion:promoter:g.-1607insG rs1799750 (human) RGD PMID:17363767 RGD:4890375 NCBI chrNW_004936551:5,167,909...5,175,149
Ensembl chrNW_004936551:5,168,044...5,174,857 		JBrowse link
G Mmp12 matrix metallopeptidase 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12634787 PMID:25106431 NCBI chrNW_004936551:5,107,567...5,117,843
Ensembl chrNW_004936551:5,106,285...5,117,843 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:increased activity:lung
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:19897563 PMID:25106431 RGD:4892307 NCBI chrNW_004936475:7,801,356...7,825,831
Ensembl chrNW_004936475:7,801,277...7,825,851 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO protein:increased activity:lung
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:14605041 PMID:18408070 PMID:19897563 PMID:25106431 RGD:4892307 RGD:5130151 RGD:8547887 NCBI chrNW_004936514:7,038,240...7,045,873
Ensembl chrNW_004936514:7,037,639...7,045,793 		JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit ISO OMIM:130700 MouseDO NCBI chrNW_004936599:3,670,759...3,677,375
Ensembl chrNW_004936599:3,670,862...3,677,239 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 ISO protein:decreased expression:lung: RGD PMID:18559366 RGD:5134973 NCBI chrNW_004936509:6,589,967...6,621,171
Ensembl chrNW_004936509:6,590,630...6,620,262 		JBrowse link
G Nfkbia NFKB inhibitor alpha treatment ISO RGD PMID:20472710 RGD:4891488 NCBI chrNW_004936494:9,537,793...9,541,187
Ensembl chrNW_004936494:9,537,008...9,541,612 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO protein:increased expression:lung
mRNA,protein:increased expression:lung		 RGD PMID:20472710 PMID:20956973 PMID:22000010 RGD:4891415 RGD:4891488 RGD:5509103 NCBI chrNW_004936538:4,052,277...4,097,051
Ensembl chrNW_004936538:4,052,448...4,097,051 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO mRNA,protein:increased expression:lung RGD PMID:20956973 RGD:4891415 NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 ISO mRNA:decreased expression:lung RGD PMID:18559366 RGD:5134973 NCBI chrNW_004936475:19,771,384...19,785,034
Ensembl chrNW_004936475:19,769,488...19,785,311 		JBrowse link
G Pgf placental growth factor ISO mRNA, protein:increased expression:lung, plasma RGD PMID:17023518 RGD:5135245 NCBI chrNW_004936488:4,098,187...4,111,108
Ensembl chrNW_004936488:4,098,225...4,111,142 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO RGD PMID:23144332 RGD:7242020 NCBI chrNW_004936477:4,881,230...5,488,208
Ensembl chrNW_004936477:5,199,881...5,488,226 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:20472710 RGD:4891488 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Ptma prothymosin alpha ISO OMIM:130700 MouseDO NCBI chrNW_004936525:5,253,723...5,258,300 JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:27982104 NCBI chrNW_004936501:8,021,090...8,065,245
Ensembl chrNW_004936501:8,020,316...8,065,332 		JBrowse link
G Sftpc surfactant protein C susceptibility ISO DNA:polymorphism: :138A>C, 186A>G (human) RGD PMID:18038590 RGD:4144115 NCBI chrNW_004936555:5,966,610...5,982,083
Ensembl chrNW_004936555:5,979,417...5,982,011 		JBrowse link
G Smo smoothened, frizzled class receptor ISO OMIM:130700 MouseDO NCBI chrNW_004936579:5,893,064...5,917,021
Ensembl chrNW_004936579:5,892,542...5,917,281 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 ISO protein:increased expression:lung: RGD PMID:20448054 RGD:10041059 NCBI chrNW_004936475:18,667,563...18,755,132
Ensembl chrNW_004936475:18,671,428...18,755,208 		JBrowse link
G Srfbp1 serum response factor binding protein 1 ISO ClinVar Annotator: match by term: Pulmonary emphysema ClinVar PMID:25741868 PMID:28492532 NCBI chrNW_004936575:2,430,074...2,493,311
Ensembl chrNW_004936575:2,430,015...2,493,329 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO RGD PMID:19445658 RGD:5147818 NCBI chrNW_004936556:1,266,621...1,421,271
Ensembl chrNW_004936556:1,266,613...1,421,275 		JBrowse link
G Tgfb1 transforming growth factor beta 1 severity ISO CTD Direct Evidence: therapeutic
associated with Pulmonary Disease, Chronic Obstructive;DNA:SNPs:promoter:rs1800469, rs1982073 (human)		 CTD
RGD		 PMID:12634787 PMID:18670143 RGD:4145272 NCBI chrNW_004936661:3,742,080...3,758,266
Ensembl chrNW_004936661:3,742,066...3,758,272 		JBrowse link
G Tlr2 toll like receptor 2 ISO protein:increased expression:alveolar macrophage RGD PMID:18399852 RGD:4145342 NCBI chrNW_004936576:522,234...531,660
Ensembl chrNW_004936576:527,434...529,788 		JBrowse link
G Tlr4 toll like receptor 4 ISO OMIM:130700 RGD
MouseDO		 PMID:17053835 RGD:4144170 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25106431 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14638
    disease of anatomical entity 14327
      respiratory system disease 4637
        lower respiratory tract disease 2089
          lung disease 2050
            obstructive lung disease 431
              chronic obstructive pulmonary disease 219
                Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome 0
                Chronic Bronchitis 15
                Mucus Inspissation of Respiratory Tract 0
                pulmonary emphysema + 59
paths to the root