RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: asthma
Accession: DOID:2841
browse the term
Definition: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. (DO)
Synonyms: exact_synonym: AS1; IRAK3-RELATED CONDITION; asthmas; bronchial asthma
narrow_synonym: ASTHMA, DIMINISHED RESPONSE TO ANTILEUKOTRIENE TREATMENT IN; adult onset asthma; airway hyperresponsiveness
broad_synonym: HNMT-RELATED CONDITION
related_synonym: ASRT1; ASRT2; ASRT3; ASRT4; ASRT5; ASRT6; ASRT7; ASRT8; Asthma-Related Traits, Susceptibility To, 1; Asthma-Related Traits, Susceptibility To, 2; Asthma-Related Traits, Susceptibility To, 3; Asthma-Related Traits, Susceptibility To, 4; Asthma-Related Traits, Susceptibility To, 5; Asthma-Related Traits, Susceptibility To, 6; Asthma-Related Traits, Susceptibility To, 7; Asthma-Related Traits, Susceptibility To, 8; allergic airway inflammation; asthma and allergic rhinitis, susceptibility to; asthma and atopy, susceptibility to; asthma, protection against; asthma, susceptibility to; asthma-traits, susceptibility to asthma, protection against; beta-2-adrenoreceptor agonist, reduced response to; childhood athma, susceptibility to; rhinoconjunctivitis, susceptibility to
primary_id: MESH:D001249
alt_id: MIM:600807 ; MIM:601690 ; MIM:607277 ; MIM:608584 ; MIM:609958 ; MIM:610906 ; MIM:611064 ; MIM:611403 ; MIM:611960 ; MIM:613207
xref: EFO:0000270 ; EFO:0005414 ; EFO:1002011 ; GARD:10246 ; ICD10CM:J45 ; ICD9CM:493 ; MONDO:0004979 ; NCI:C28397
For additional species annotation, visit the
Alliance of Genome Resources .
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ABCB1
ATP binding cassette subfamily B member 1
ISO
protein:increased expression:blood, lymphocyte
RGD
PMID:19484671
RGD:4890020
NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
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ABCC1
ATP binding cassette subfamily C member 1
ISO
RGD
PMID:18931056
RGD:5128825
NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
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ABO
ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase
no_association
ISO
RGD
PMID:16008680 PMID:19771478
RGD:5128831 RGD:5128835
NCBI chr 9:49,746,749...49,758,317
Ensembl chr 9:49,748,693...49,758,479
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ACE
angiotensin I converting enzyme
susceptibility
ISO
DNA:polymorphism (human)
RGD
PMID:19383228 PMID:19484664
RGD:4140913 RGD:4140919
NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358
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ACSL3
acyl-CoA synthetase long chain family member 3
ISO
DNA:hypermethylation:promoter
RGD
PMID:19221603
RGD:13831295
NCBI chr37:28,882,264...28,929,451
Ensembl chr37:28,864,147...28,938,866
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ADA
adenosine deaminase
susceptibility
ISO
DNA:polymorphisms (human)
RGD
PMID:16754522
RGD:5128848
NCBI chr24:32,083,786...32,119,810
Ensembl chr24:32,083,931...32,111,160
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ADAM33
ADAM metallopeptidase domain 33
disease_progression susceptibility no_association
ISO
mRNA:increased expression:bronchus mRNA:increased expression:lung DNA:SNPs (human) DNA:polymorphism: :p.M764T (human) DNA:SNPs:introns,exon:7575G>A, 11188A>T, 12433T>C (human) DNA:SNPs: :multiple (human)
RGD
PMID:16893396 PMID:17339047 PMID:17961406 PMID:18778489 PMID:19635592 PMID:19940503 More...
RGD:4145359 RGD:4145360 RGD:4145378 RGD:4145379 RGD:4145380 RGD:4145382
NCBI chr24:17,668,377...17,682,217
Ensembl chr24:17,668,500...17,681,209
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ADAM8
ADAM metallopeptidase domain 8
severity
ISO
mRNA:increased expression:respiratory tract mRNA:increased expression:bronchus
RGD
PMID:17339047 PMID:19373511 PMID:20194813
RGD:4145380 RGD:5128872 RGD:5128878
NCBI chr28:40,853,665...40,865,604
Ensembl chr28:40,855,509...40,863,747
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ADCY2
adenylate cyclase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21912604
NCBI chr34:6,139,931...6,527,677
Ensembl chr34:6,140,276...6,527,677
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ADCYAP1R1
ADCYAP receptor type I
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21059121
NCBI chr14:43,707,683...43,761,166
Ensembl chr14:43,701,745...43,756,571
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ADH5
alcohol dehydrogenase 5 (class III), chi polypeptide
susceptibility
ISO
protein:increased expression:respiratory system fluid/secretion DNA:SNPs: :rs1154404, rs28730619 (human)
RGD
PMID:15919956 PMID:17543375 PMID:19395503 PMID:19514054
RGD:5128882 RGD:5128890 RGD:5128891 RGD:5128892
NCBI chr32:21,249,459...21,261,130
Ensembl chr32:21,249,739...21,265,048
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ADIPOQ
adiponectin, C1Q and collagen domain containing
ISO
RGD
PMID:19168697
RGD:5686821
NCBI chr34:19,398,310...19,410,519
Ensembl chr34:19,354,825...19,409,844
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ADORA1
adenosine A1 receptor
ISO
protein:increased expression:bronchus DNA:SNPs: :1405C>T (human)
RGD
PMID:17959644 PMID:19019667 PMID:20400685
RGD:4145444 RGD:4890386 RGD:5129097
NCBI chr 7:44,819...74,217
Ensembl chr 7:44,820...73,051
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ADORA2A
adenosine A2a receptor
ISO
DNA:SNP (human) mRNA:decreased expression:aorta
RGD
PMID:16339780 PMID:17293374 PMID:18310516 PMID:19019667
RGD:4890366 RGD:4890380 RGD:4890385 RGD:4890386
NCBI chr26:28,141,076...28,150,600
Ensembl chr26:28,141,076...28,150,598
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ADRB2
adrenoceptor beta 2
susceptibility
ISO
ClinVar Annotator: match by term: Beta-2-adrenoreceptor agonist, reduced response to DNA:SNP: :-1023A>G (human)
ClinVar RGD
PMID:8383511 PMID:15284533 PMID:16596417 PMID:19638684
RGD:4145081
NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298
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AGER
advanced glycosylation end-product specific receptor
treatment onset
ISO
CTD Direct Evidence: marker/mechanism protein:decreased expression:lung (rat)
RGD CTD
PMID:21920897 PMID:23304218 PMID:33075463
RGD:6767554 RGD:7244279
NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129
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AGTR1
angiotensin II receptor type 1
ISO
RGD
PMID:19080339
RGD:5147457
NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238
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AGTR2
angiotensin II receptor type 2
ISO
mRNA, protein:increased expression:lung
RGD
PMID:19080339
RGD:5147457
NCBI chr X:88,703,551...88,708,451
Ensembl chr X:88,705,765...88,706,853
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ALDH2
aldehyde dehydrogenase 2 family member
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9600491 PMID:11506308
NCBI chr26:9,319,109...9,361,021
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ALOX15
arachidonate 15-lipoxygenase
ISO
protein:increased expression:lung
RGD
PMID:18692885 PMID:19628725
RGD:5509605 RGD:5509784
NCBI chr 5:31,883,544...31,891,357
Ensembl chr 5:31,882,501...32,038,119
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ALOX5
arachidonate 5-lipoxygenase
severity susceptibility treatment no_association
ISO
DNA:repeat:promoter (human) mRNA:increased expression:blood, leukocyte DNA:polymorphism:cds:p.E254K (human) CTD Direct Evidence: marker/mechanism protein:increased expression:lung DNA:polymorphism:promoter (human)
RGD CTD OMIM
PMID:8879219 PMID:9642160 PMID:10369259 PMID:11035107 PMID:12911785 PMID:16364163 PMID:17394438 PMID:18204779 PMID:19033731 PMID:20128419 More...
RGD:4890407 RGD:4890408 RGD:4890410 RGD:4890413 RGD:4890415 RGD:4890422 RGD:5147462 RGD:5147465 RGD:5147467 RGD:734557
NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609
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ALOX5AP
arachidonate 5-lipoxygenase activating protein
no_association susceptibility
ISO
DNA:repeat:promoter:-169(A)21 (human) mRNA:increased expression:blood, leukocyte DNA:substitution, repeat:promoter:-336G>A, -169(A)19-23 (human) DNA:polymorphism:promoter (human) protein:increased expression:lung DNA:SNP: :rs10507391 (human) DNA:SNPs (human) DNA:polymorphisms:intron:IVS2+12C>A, IVS2+105T>C (human)
RGD
PMID:8879219 PMID:9642160 PMID:10527888 PMID:11035107 PMID:12911785 PMID:15784112 PMID:18547289 PMID:20067482 PMID:20128419 More...
RGD:4890405 RGD:4890407 RGD:4890409 RGD:4890422 RGD:5147462 RGD:5147464 RGD:5147465 RGD:5147466 RGD:5147467
NCBI chr25:9,320,868...9,351,056
Ensembl chr25:9,320,864...9,351,836
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AMBP
alpha-1-microglobulin/bikunin precursor
ISO
protein:increased expression:serum
RGD
PMID:14621078
RGD:6904149
NCBI chr11:68,338,644...68,353,366
Ensembl chr11:68,338,389...68,351,994
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ANXA1
annexin A1
ISO
RGD
PMID:22092555
RGD:7421657
NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011
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AREG
amphiregulin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15696081
NCBI chr13:62,925,761...62,936,753
Ensembl chr13:62,926,301...62,936,738
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ARG1
arginase 1
ISO
CTD Direct Evidence: marker/mechanism mRNA, protein:increased expression:lung, mononuclear cell (human) DNA:SNP: :rs2781667 (human) mRNA:increased expression:lung (mouse)
CTD RGD
PMID:12813022 PMID:19281908 PMID:19800904 PMID:20124949
RGD:4143187 RGD:5129205
NCBI chr12:242,717...255,736
Ensembl chr12:242,714...255,305
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ARG2
arginase 2
severity susceptibility
ISO
DNA:SNP: :rs3742879, rs17249437 (human) DNA:SNPs (human) mRNA:increased expression:lung (mouse) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12813022 PMID:16387594 PMID:19281908 PMID:20124949
RGD:4143187 RGD:5129205 RGD:5129207
NCBI chr 8:41,588,051...41,619,406
Ensembl chr 8:41,588,150...41,619,402
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B9D2
B9 domain containing 2
onset no_association
ISO
DNA:SNP: :-509C>T (human) mRNA:increased expression:lung DNA:SNP:cds:915G>C (human) DNA:polymorphism: :-509C>T (human) CTD Direct Evidence: marker/mechanism protein:increased expression:serum DNA:polymorphisms: :multiple (human) DNA:SNPs:promoter, exon:multiple (human)
RGD CTD
PMID:16365456 PMID:17673695 PMID:18366906 PMID:18711258 PMID:19046298 PMID:19096005 PMID:19136038 PMID:19138248 PMID:19222424 PMID:19317336 PMID:19533439 PMID:19620629 PMID:20485865 More...
RGD:4143443 RGD:4145113 RGD:4145132 RGD:4145139 RGD:4145142 RGD:4145143 RGD:4145144 RGD:4145280 RGD:4145295 RGD:4145297 RGD:4145299
NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885
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BCL2
BCL2 apoptosis regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18357729
NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
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BDKRB2
bradykinin receptor B2
onset
ISO
protein:increased expression:blood, eosinophil DNA:polymorphism:exon (human)
RGD
PMID:8856156 PMID:11517947 PMID:14727005 PMID:19038786
RGD:4890454 RGD:4890456 RGD:4891028 RGD:4891042
NCBI chr 8:64,974,588...65,005,682
Ensembl chr 8:64,974,997...65,003,407
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BDNF
brain derived neurotrophic factor
severity susceptibility
ISO
protein:decreased expression:blood, eosinophil protein:increased expression:plasma DNA:SNP,haplotypes: :rs10767664,rs12273539,rs962369(human) DNA:polymorphisms: :p.V66M (rs6265) (human) DNA:polymorphisms: :p.V66M, -270C>T (human)
RGD
PMID:11737043 PMID:12752594 PMID:17584309 PMID:19895626 PMID:20874832 PMID:21723144 More...
RGD:4891063 RGD:4891067 RGD:4891117 RGD:4891122 RGD:4891123 RGD:8655967
NCBI chr21:48,191,580...48,243,699
Ensembl chr21:48,192,670...48,204,480
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BGLAP
bone gamma-carboxyglutamate protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8429434
NCBI chr 7:41,630,092...41,630,976
Ensembl chr 7:41,630,098...41,665,791
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BMPR1B
bone morphogenetic protein receptor type 1B
ISO
protein:decreased expression:bronchus
RGD
PMID:18292470
RGD:5129470
NCBI chr32:17,761,555...17,978,056
Ensembl chr32:17,870,904...18,016,444
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BMPR2
bone morphogenetic protein receptor type 2
ISO
protein:decreased expression:bronchus
RGD
PMID:18292470
RGD:5129470
NCBI chr37:11,342,292...11,540,199
Ensembl chr37:11,342,384...11,533,024
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C3
complement C3
severity
ISO
Interaction with IL4RA DNA:SNPs: :multiple (human) DNA:SNP:intron:rs11569562 (human) protein:increased expression:serum protein:increased expression:respiratory system fluid/secretion DNA:SNP: :4896C>T (human)
RGD
PMID:11591733 PMID:15278436 PMID:16355111 PMID:18566738 PMID:20395963 PMID:20402389 PMID:20589464 PMID:20802484 More...
RGD:5129501 RGD:5129505 RGD:5129512 RGD:5129517 RGD:5129519 RGD:5129537 RGD:5129538 RGD:5129681
NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761
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C3AR1
complement C3a receptor 1
severity
ISO
mRNA:increased expression:lung protein:increased expression:lung, leukocyte
RGD
PMID:15278436 PMID:15940127 PMID:17544263 PMID:20045013 PMID:20802484
RGD:5129512 RGD:5129560 RGD:5129561 RGD:5129681 RGD:5129686
NCBI chr27:37,431,745...37,439,858
Ensembl chr27:37,433,792...37,435,246
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C5
complement C5
severity
ISO
mRNA:decreased expression:lung
RGD
PMID:10973279 PMID:11591795 PMID:15278436 PMID:20143644 PMID:20802484
RGD:1600651 RGD:5129512 RGD:5129681 RGD:5129706 RGD:5130158
NCBI chr11:73,953,727...74,029,919
Ensembl chr11:73,953,727...74,029,851
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C5AR1
complement C5a receptor 1
severity
ISO
protein:increased expression:lung, leukocyte protein:increased expression:respiratory tract
RGD
PMID:15940127 PMID:16511606 PMID:17544263 PMID:20802484
RGD:5129560 RGD:5129561 RGD:5129681 RGD:5130166
NCBI chr 1:108,659,637...108,704,217
Ensembl chr 1:108,659,637...108,675,401
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CARD11
caspase recruitment domain family member 11
susceptibility
ISO
ClinVar Annotator: match by term: Asthma
RGD ClinVar
PMID:16751370 PMID:18323416 PMID:23027925 PMID:23129749 PMID:25352053 PMID:25741868 PMID:26861442 PMID:28492532 PMID:28824638 PMID:29472930 More...
RGD:11100037
NCBI chr 6:14,273,115...14,331,029
Ensembl chr 6:14,210,114...14,332,094
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CARM1
coactivator associated arginine methyltransferase 1
ISO
mRNA:decreased expression:lung
RGD
PMID:20423833
RGD:9491823
NCBI chr20:50,328,466...50,371,845
Ensembl chr20:50,331,030...50,348,195
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CAT
catalase
severity
ISO
protein:decreased activity DNA:polymorphism:promoter:-21A>T (human) protein:decreased activity:respiratory system fluid/secretion protein:increased expression:erythrocyte DNA:polymorphism:promoter:-262C>T (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16622028 PMID:18048809 PMID:19373626 PMID:19475625
RGD:5130751 RGD:5130753 RGD:5130856 RGD:5130867
NCBI chr18:33,383,005...33,422,447
Ensembl chr18:33,383,005...33,422,447
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CCL1
C-C motif chemokine ligand 1
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:20455898
RGD:4891420
NCBI chr 9:38,931,895...38,936,969
Ensembl chr 9:38,933,514...38,961,187
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CCL17
C-C motif chemokine ligand 17
ISO
mRNA:increased expression:lung protein:increased expression:respiratory system fluid/secretion
RGD
PMID:11160256 PMID:15947487 PMID:15993846 PMID:20074456 PMID:20237293
RGD:2306304 RGD:4145486 RGD:4145487 RGD:4145513 RGD:4145603
NCBI chr 2:59,001,463...59,014,347
Ensembl chr 2:59,001,464...59,005,230
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CCL19
C-C motif chemokine ligand 19
ISO
protein:increased expression:bronchus submucosa, mast cell
RGD
PMID:16959919
RGD:5130911
NCBI chr11:51,357,706...51,359,207
Ensembl chr11:51,340,530...51,359,365
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CCL2
C-C motif chemokine ligand 2
treatment severity
ISO
CTD Direct Evidence: marker/mechanism DNA:haplotype::-2518A>G (human) mRNA:increased expression:lung (mouse) protein:increased expression:lung protein:increased expression:serum
CTD RGD
PMID:12055264 PMID:17964702 PMID:19373627 PMID:20205697 PMID:23454776 PMID:25441643 More...
RGD:11528569 RGD:11528570 RGD:2307055 RGD:4145509 RGD:4891466 RGD:8551842
NCBI chr 9:39,008,187...39,009,932
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CCL20
C-C motif chemokine ligand 20
ISO
protein:increased expression:respiratory system fluid/secretion associated with Allergic Rhinitis;protein:increased expression:serum
RGD
PMID:18422729 PMID:22469443
RGD:7483597 RGD:7483618
NCBI chr25:40,506,385...40,509,903
Ensembl chr25:40,506,753...40,509,709
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CCL22
C-C motif chemokine ligand 22
ISO
mRNA:increased expression:lung mRNA, protein:increased expression:respiratory system mucosa, respiratory system fluid/secretion protein:increased expression:respiratory system fluid/secretion
RGD
PMID:10384142 PMID:15993846 PMID:18316417 PMID:18684970
RGD:2306304 RGD:4145489 RGD:4891474 RGD:4891475
NCBI chr 2:59,039,650...59,045,519
Ensembl chr 2:59,040,539...59,045,625
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CCL24
C-C motif chemokine ligand 24
susceptibility
ISO
protein:increased expression:plasma DNA:SNPs: :304C>A, 1272A>G (human) protein:increased expression:respiratory system fluid/secretion DNA:SNP: :1265A>G (human) DNA:SNPs: :179T>C, 275C>T (human)
RGD
PMID:12761043 PMID:12952266 PMID:15207712 PMID:16304252 PMID:17060636 PMID:17548626 PMID:18712274 More...
RGD:4891483 RGD:4891484 RGD:4891485 RGD:4891495 RGD:4891496 RGD:5130930 RGD:5130932
NCBI chr 6:7,166,165...7,179,606
Ensembl chr 6:7,166,479...7,180,051
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CCL26
C-C motif chemokine ligand 26
treatment
ISO
protein:increased expression:plasma DNA:SNPs: :77C>T, 716A>G, 1579G>A (human) DNA:SNPs: :77C>T, 2497T>G (human)
RGD
PMID:15207712 PMID:16304252 PMID:18712274 PMID:25399816 PMID:25530546
RGD:11081163 RGD:11087575 RGD:4891483 RGD:4891495 RGD:5130930
NCBI chr 6:7,151,352...7,154,509
Ensembl chr 6:7,151,212...7,154,726
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CCL27
C-C motif chemokine ligand 27
ISO
RGD
PMID:19541356
RGD:5130899
NCBI chr11:51,334,870...51,338,752
Ensembl chr11:51,334,778...51,335,591
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CCL28
C-C motif chemokine ligand 28
ISO
mRNA:increased expression:lung (mouse)
RGD
PMID:16290206
RGD:4892195
NCBI chr 4:66,567,139...66,597,310
Ensembl chr 4:66,566,989...66,597,459
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CCL4
chemokine (C-C motif) ligand 4
ISO
RGD
PMID:18774390
RGD:5130915
NCBI chr 9:37,681,342...37,682,691
Ensembl chr 9:37,676,966...37,710,209
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CCL5
C-C motif chemokine ligand 5
susceptibility
ISO
DNA:transition:5' utr:-403G>A (human) protein:increased expression:smooth muscle cell protein:increased expression:lung, secretion (mouse) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:8534483 PMID:18208670 PMID:20092989 PMID:20430255
RGD:2307112 RGD:4891381 RGD:4891430
NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852
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CCL7
C-C motif chemokine ligand 7
ISO
Promoter polymorphism
RGD
PMID:19965981 PMID:21388664
RGD:5130979 RGD:5130983
NCBI chr 9:38,994,638...38,996,103
Ensembl chr 9:38,993,911...39,010,483
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CCR1
chemokine (C-C motif) receptor 1
severity
ISO
mRNA:increased expression:lung associated with Respiratory Syncytial Virus Infections
RGD
PMID:15593301 PMID:15654816
RGD:5688158 RGD:5688159
NCBI chr20:42,421,356...42,427,177
Ensembl chr20:42,421,356...42,426,958
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CCR2
C-C motif chemokine receptor 2
susceptibility
ISO
DNA:SNP:cds:p.V64I (human) protein:increased expression:lung, dendritic cell (mouse) DNA:haplotype:cds:p.V64I(human)
RGD
PMID:17298432 PMID:19917684 PMID:23454776
RGD:4145110 RGD:8549811 RGD:8551842
NCBI chr20:42,305,344...42,313,258
Ensembl chr20:42,307,580...42,308,698
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CCR3
C-C motif chemokine receptor 3
ISO
protein:increased expression:respiratory system fluid/secretion, neutrophil DNA:SNP:exon:51T>C (human)
RGD
PMID:16978084 PMID:17145927 PMID:18699933 PMID:19017998 PMID:19657453 PMID:20134116 PMID:20220260 More...
RGD:1601020 RGD:4145618 RGD:4145623 RGD:4145632 RGD:4145633 RGD:4145638 RGD:4145646
NCBI chr20:42,382,380...42,398,449
Ensembl chr20:42,383,135...42,384,217
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CCR4
C-C motif chemokine receptor 4
ISO
mRNA:increased expression:lung
RGD
PMID:15993846
RGD:2306304
NCBI chr23:3,844,072...3,847,770
Ensembl chr23:3,844,173...3,845,255
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CCR5
C-C motif chemokine receptor 5
no_association
ISO
mRNA:increased expression:lung (mouse) DNA:polymorphism, frameshift mutation: :-59029G>A, p.S185_T195del (rs333) (human) protein:decreased expression:blood, lymphocyte (human) DNA:frameshift mutation:cds:p.S185_T195del rs333 (human)
RGD
PMID:15256090 PMID:16474097 PMID:18094012 PMID:20220260 PMID:23454776
RGD:4145638 RGD:4892088 RGD:4892093 RGD:4892108 RGD:8551842
NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952
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CCR6
C-C motif chemokine receptor 6
ISO
protein:increased expression:lung, dendritic cell (mouse)
RGD
PMID:19917684
RGD:8549811
NCBI chr 1:54,932,798...54,960,646
Ensembl chr 1:54,932,690...54,959,740
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CCR7
C-C motif chemokine receptor 7
ISO
protein:increased expression:lung, dendritic cell (mouse)
RGD
PMID:19917684
RGD:8549811
NCBI chr 9:22,077,976...22,092,818
Ensembl chr 9:22,068,775...22,090,656
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CCR8
C-C motif chemokine receptor 8
ISO
mRNA:increased expression:lung
RGD
PMID:15993846
RGD:2306304
NCBI chr23:9,013,242...9,019,513
Ensembl chr23:9,018,060...9,018,589
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CCR9
C-C motif chemokine receptor 9
ISO
mRNA, protein:increased expression:blood, mature NK T cell
RGD
PMID:16210593
RGD:5130925
NCBI chr20:42,607,024...42,616,823
Ensembl chr20:42,607,024...42,616,823
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CD14
CD14 molecule
severity no_association susceptibility
ISO
protein:increased expression:serum protein:increased expression:serum|DNA:polymorphism:promoter:c. -159C>T (human) DNA:polymorphism:promoter:c. -260C>T (human) CTD Direct Evidence: marker/mechanism DNA:SNPs: :
RGD CTD
PMID:15741437 PMID:15940135 PMID:16387800 PMID:17607003 PMID:18312481 PMID:19096003 More...
RGD:4144208 RGD:4144228 RGD:4144813 RGD:4144814 RGD:4144815
NCBI chr 2:35,790,505...35,792,967
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CD1D
CD1d molecule
susceptibility
ISO
associated with fasciolopsiasis
RGD
PMID:20304473
RGD:4140417
NCBI chr38:23,489,169...23,491,712
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CD209
CD209 molecule
ISO
RGD
PMID:21471959
RGD:5131188
NCBI chr20:52,517,759...52,542,085
Ensembl chr20:52,518,036...52,520,942
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CD274
CD274 molecule
treatment
ISO
associated with Chlamydia pneumonia
RGD
PMID:26378990
RGD:41412180
NCBI chr 1:93,461,735...93,605,772
Ensembl chr 1:93,585,518...93,603,522
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CD28
CD28 molecule
ISO
RGD
PMID:21356099
RGD:5131612
NCBI chr37:12,503,849...12,536,362
Ensembl chr37:12,503,811...12,532,854
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CD40
CD40 molecule
treatment
ISO
RGD
PMID:19159017 PMID:19220210 PMID:20205594 PMID:20941750
RGD:4144188 RGD:4892277 RGD:5132272 RGD:8547792
NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301
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CD40LG
CD40 ligand
severity
ISO
RGD
PMID:9502776
RGD:11352238
NCBI chr X:107,001,421...107,023,007
Ensembl chr X:107,010,890...107,023,006
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CD80
CD80 molecule
ISO
RGD
PMID:21051864 PMID:21352203 PMID:21440530
RGD:5132619 RGD:5132620 RGD:5132621
NCBI chr33:23,177,136...23,208,421
Ensembl chr33:23,177,138...23,201,380
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CD86
CD86 molecule
treatment
ISO
protein:increased expression:blood, B cell (human) protein:increased expression:lung, dendritic cell (rat) DNA:snp:exon:p.I179V rs2681417 (human) protein:increased expression:lung, alveolar macrophage (mouse)
RGD
PMID:9449507 PMID:9551945 PMID:17513529 PMID:20668438 PMID:20941750 PMID:25344652 More...
RGD:11354965 RGD:4892199 RGD:4892202 RGD:4892277 RGD:4892280 RGD:4892555
NCBI chr33:25,256,267...25,318,855
Ensembl chr33:25,256,267...25,318,087
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CDH1
cadherin 1
ISO
RGD
PMID:21540309
RGD:5132878
NCBI chr 5:80,757,508...80,834,878
Ensembl chr 5:80,757,508...80,834,878
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CDHR3
cadherin related family member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24241537
NCBI chr18:14,437,083...14,497,711
Ensembl chr18:14,437,751...14,497,646
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CFTR
CF transmembrane conductance regulator
susceptibility
ISO
DNA:deletion: :p.F508del(human)
RGD
PMID:20298391
RGD:4140387
NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
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CHAT
choline O-acetyltransferase
ISO
Protein:decreased expression:lung epithelium
RGD
PMID:17328924
RGD:5686690
NCBI chr28:1,480,364...1,528,858
Ensembl chr28:1,482,202...1,528,776
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CHI3L1
chitinase 3 like 1
susceptibility
ISO
ClinVar Annotator: match by term: Asthma-related traits, susceptibility to, 7
OMIM ClinVar
PMID:18403759
NCBI chr 7:25,620...32,954
Ensembl chr 7:26,316...33,427
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CHIA
chitinase acidic
no_association
ISO
DNA:snps:5' utr, cds:multiple (human) DNA:snps:multiple (human) mRNA:increased expression:lung, epithelial cell (human) mRNA:increased expression:lung (mouse)
RGD
PMID:14734765 PMID:15192232 PMID:16179638 PMID:19548841 PMID:20226308
RGD:4985150 RGD:4990463 RGD:4996473 RGD:5024921 RGD:5024922
NCBI chr 6:40,754,906...40,766,779
Ensembl chr 6:40,754,993...40,766,891
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CHML
CHM like Rab escort protein
ISO
RGD
PMID:18343558
RGD:5133238
NCBI chr 7:33,027,051...33,040,711
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CHRM1
cholinergic receptor muscarinic 1
ISO
RGD
PMID:16931638
RGD:5133416
NCBI chr18:53,783,938...53,797,750
Ensembl chr18:53,795,326...53,796,708
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CHRM2
cholinergic receptor muscarinic 2
ISO
DNA:SNP: :rs6962027 (human)
RGD
PMID:19308904
RGD:5509586
NCBI chr16:11,515,727...11,665,651
Ensembl chr16:11,515,426...11,664,977
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CHRM3
cholinergic receptor muscarinic 3
severity
ISO
RGD
PMID:18348887 PMID:20394512
RGD:5133437 RGD:5133438
NCBI chr 4:504,663...999,550
Ensembl chr 4:506,990...520,613
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CHUK
component of inhibitor of nuclear factor kappa B kinase complex
ISO
RGD
PMID:21496385
RGD:5133703
NCBI chr28:12,964,670...13,001,557
Ensembl chr28:12,965,479...13,001,512
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CLCA1
chloride channel accessory 1
susceptibility
ISO
DNA:SNPs (human)
RGD
PMID:11296262 PMID:15318163 PMID:17898169
RGD:4145653 RGD:4145656 RGD:4145661
NCBI chr 6:61,620,755...61,650,111
Ensembl chr 6:61,620,995...61,650,083
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CLDN18
claudin 18
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27215490
NCBI chr23:34,229,115...34,257,431
Ensembl chr23:34,228,992...34,255,650
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CMA1
chymase 1
severity no_association susceptibility
ISO
protein:increased expression:lung epithelium, mast cell (human) DNA:polymorphism:5' utr:g.-1903G>A rs1800875 (human) DNA:duplications:3' utr:g.*254-?dupTG, dupGA (human)
RGD
PMID:15248847 PMID:15924217 PMID:20813890
RGD:1625396 RGD:1625397 RGD:5128804
NCBI chr 8:4,438,244...4,441,189
Ensembl chr 8:4,438,244...4,441,189
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CRHR1
corticotropin releasing hormone receptor 1
ISO
DNA:SNPs: :rs1876828, rs242939, rs242941 (human) DNA:SNP: :RS242941 (human)
RGD
PMID:16113459 PMID:19663668
RGD:5147485 RGD:5147488
NCBI chr 9:9,708,696...9,763,281
Ensembl chr 9:9,714,204...9,763,402
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CRHR2
corticotropin releasing hormone receptor 2
ISO
DNA:SNPs: :multiple (human)
RGD
PMID:18408560
RGD:5130938
NCBI chr14:43,366,849...43,414,398
Ensembl chr14:43,368,340...43,415,142
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CRP
C-reactive protein
ISO
protein:increased expression:serum
RGD
PMID:21140796
RGD:5131288
NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166
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CSF2
colony stimulating factor 2
severity
ISO
protein:increased expression:lung protein:increased expression:sputum
RGD
PMID:9717963 PMID:19213775 PMID:20405019
RGD:10449521 RGD:5131473 RGD:5131476
NCBI chr11:20,342,880...20,346,959
Ensembl chr11:20,344,648...20,346,959
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CSF2RB
colony stimulating factor 2 receptor subunit beta
ISO
RGD
PMID:17145927
RGD:1601020
NCBI chr10:27,541,645...27,566,907
Ensembl chr10:27,541,647...27,567,278
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CSF3
colony stimulating factor 3
ISO
protein:increased expression:lung
RGD
PMID:20405019 PMID:21396376
RGD:5131473 RGD:5133731
NCBI chr 9:22,529,643...22,532,326
Ensembl chr 9:22,530,698...22,533,108
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CTLA4
cytotoxic T-lymphocyte associated protein 4
severity treatment no_association
ISO
DNA:SNPs: :multiple (human) DNA:polymorphisms:promoter, exon:-318C>T 49A>G (human) DNA:polymorphism:promoter:-318C>T (human) CTD Direct Evidence: marker/mechanism DNA:SNP: :rs3087243 (human) DNA:SNPs:promoter, exon:-1147C>T, -318C>T, 49A>G (human) protein:increased expression:serum
RGD CTD
PMID:11726402 PMID:12114354 PMID:12956753 PMID:15316504 PMID:15871446 PMID:16677453 PMID:16708626 PMID:16926542 PMID:17237396 PMID:17469155 PMID:18699801 PMID:19895365 PMID:28807506 More...
RGD:11344922 RGD:4891510 RGD:4891514 RGD:4891516 RGD:4891517 RGD:4891519 RGD:4891521 RGD:4891522 RGD:4891526 RGD:4891527 RGD:4891528 RGD:4891529
NCBI chr37:12,647,712...12,653,874
Ensembl chr37:12,634,563...12,653,874
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CTNNA3
catenin alpha 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19187332
NCBI chr 4:17,364,121...19,035,836
Ensembl chr 4:17,372,245...19,017,093
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CX3CL1
C-X3-C motif chemokine ligand 1
ISO
protein:increased expression:plasma
RGD
PMID:14657873
RGD:4891906
NCBI chr 2:59,022,794...59,032,095
Ensembl chr 2:59,022,794...59,032,095
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CX3CR1
C-X3-C motif chemokine receptor 1
no_association
ISO
DNA:SNPs: :p.V249I, rs2669849 (human) DNA:polymorphisms: :p.V249I, p.T280M (human)
RGD
PMID:17082760 PMID:17505143 PMID:21037587
RGD:4891882 RGD:4891895 RGD:4891904
NCBI chr23:8,937,069...8,954,738
Ensembl chr23:8,938,906...8,952,808
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CXCL10
C-X-C motif chemokine ligand 10
ISO
protein:decreased expression:plasma
RGD
PMID:11994485 PMID:16602032 PMID:17302903
RGD:5135439 RGD:5135452 RGD:5135457
NCBI chr32:598,406...599,925
Ensembl chr32:597,987...599,979
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CXCL14
C-X-C motif chemokine ligand 14
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21150878
NCBI chr11:23,598,640...23,606,850
Ensembl chr11:23,599,645...23,606,823
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CXCR3
C-X-C motif chemokine receptor 3
susceptibility severity
ISO
protein:decreased expression:respiratory system fluid/secretion, T cell DNA:SNP:intron:IVS1+234G>A (human)
RGD
PMID:16043121 PMID:16548899 PMID:17641057 PMID:18094012
RGD:4892088 RGD:5135484 RGD:5143932 RGD:5143934
NCBI chr X:55,882,433...55,884,582
Ensembl chr X:55,882,433...55,884,582
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CYBA
cytochrome b-245 alpha chain
susceptibility
ISO
DNA:SNPs: :-930A>G, 242C>T, 640A>G (human) DNA:polymorphism: :-930A>G (human)
RGD
PMID:18716406 PMID:19459419
RGD:4311041 RGD:4772770
NCBI chr 5:64,692,865...64,701,056
Ensembl chr 5:64,692,123...64,704,893
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CYP1A1
cytochrome P450 family 1 subfamily A member 1
ISO
mRNA, protein:increased expression, decreased activity:lung
RGD
PMID:12415424
RGD:4892074
NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
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CYP2D15
cytochrome P450 family 2 subfamily D member 15
ISO
DNA:polymorphism: :1934G>A (human)
RGD
PMID:19575027
RGD:5143944
NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298
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CYP2E1
cytochrome P450 family 2 subfamily E member 1
ISO
CTD Direct Evidence: marker/mechanism mRNA:decreased expression:leukocyte
RGD CTD
PMID:17081494 PMID:20514434 PMID:28807506
RGD:4892076 RGD:4892220
NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754
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CYSLTR1
cysteinyl leukotriene receptor 1
no_association severity
ISO
DNA:SNP: :927T>C (human) DNA:SNPs:promoter, exon:multiple (human) DNA:SNPs:promoter:-634C>T, -475A>C, -336A>G (human) mRNA, protein:increased expression:respiratory system mucosa
RGD
PMID:8087328 PMID:11591188 PMID:16123393 PMID:16387808 PMID:16630147 PMID:16771777 PMID:16776674 PMID:17153879 PMID:17689528 More...
RGD:4781449 RGD:4781742 RGD:4782072 RGD:4784257 RGD:4843543 RGD:4847129 RGD:4848936 RGD:4888514 RGD:4889116
NCBI chr X:60,462,290...60,513,155
Ensembl chr X:60,463,526...60,464,548
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CYSLTR2
cysteinyl leukotriene receptor 2
ISO
DNA:polymorphism: :-1220A>C (human) DNA:polymorphism: :601A>G (human)
RGD
PMID:15454733 PMID:15475736
RGD:5144002 RGD:5144003
NCBI chr22:2,914,960...2,962,517
Ensembl chr22:2,917,514...2,918,551
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DCN
decorin
ISO
RGD
PMID:16387756
RGD:2311423
NCBI chr15:31,833,492...31,887,699
Ensembl chr15:31,833,746...31,877,417
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DEFB1
defensin beta 1
susceptibility
ISO
DNA:SNP: :-1816 T>C (human) DNA:SNPs:5' utr:g.-52G>A, g.-44C>G, g.-20G>A (human)
RGD
PMID:15696078 PMID:16435024
RGD:4892254 RGD:4892263
NCBI chr16:58,871,018...58,881,592
Ensembl chr16:58,871,018...58,881,592
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DLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
susceptibility
ISO
DNA:polymorphism: :rs3916765(human)
RGD
PMID:20159242
RGD:13506913
NCBI chr12:2,221,181...2,227,600
Ensembl chr12:2,221,137...2,227,600
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DLA-DQB1
major histocompatibility complex, class II, DQ beta 1
disease_progression no_association susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:polymorphisms: : DNA:polymorphisms (human) Alternaria sensitive asthma
CTD RGD
PMID:10792356 PMID:11802952 PMID:12890388 PMID:19052351 PMID:20159242 PMID:20214848 PMID:20298583 PMID:23331206 More...
RGD:13506906 RGD:13506913 RGD:4144113 RGD:4144181 RGD:5147617 RGD:5147799 RGD:5147831
NCBI chr12:2,305,307...2,307,711
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DLA-DRA
MHC class II DR alpha chain
susceptibility
ISO
DNA:polymorphisms: :
RGD
PMID:20159242
RGD:13506913
NCBI chr12:2,133,026...2,137,825
Ensembl chr12:2,132,499...2,168,975
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DLA-DRB1
MHC class II DLA DRB1 beta chain
no_association susceptibility severity
ISO
CTD Direct Evidence: marker/mechanism DNA:polymorphism (human) DNA:polymorphisms: :
CTD RGD
PMID:10051703 PMID:16792590 PMID:19439981 PMID:19528258 PMID:20159242 PMID:20214848 PMID:20486920 PMID:23331206 More...
RGD:1331670 RGD:13506906 RGD:13506913 RGD:4144181 RGD:4144196 RGD:5147607 RGD:5147663
NCBI chr12:2,151,409...2,164,564
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DLA88
MHC class I DLA-88
susceptibility
ISO
DNA:polymorphism:
RGD
PMID:28380482
RGD:13506910
NCBI chr12:892,442...895,691
Ensembl chr12:892,388...1,021,690
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DNAH5
dynein axonemal heavy chain 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21912604
NCBI chr34:816,088...1,040,052
Ensembl chr34:805,455...1,038,273
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DNMT1
DNA methyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism DNA,mRNA:hypermethylation,decreased expression:promoter,respiratory tract:
CTD RGD
PMID:23196709 PMID:23423710
RGD:9588646
NCBI chr20:50,872,213...50,928,352
Ensembl chr20:50,879,527...50,928,029
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DPP10
dipeptidyl peptidase like 10
ISO
DNA:SNP:exon (human) protein:increased expression:bronchus DNA:SNP: :rs10208402 (human) DNA:SNPs (human)
RGD
PMID:14566338 PMID:17967935 PMID:19672052 PMID:21103062
RGD:4889866 RGD:4892275 RGD:4892276 RGD:4892278
NCBI chr19:33,432,091...34,707,133
Ensembl chr19:33,434,154...34,706,758
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EBI3
Epstein-Barr virus induced 3
ISO
RGD
PMID:21255010
RGD:5128488
NCBI chr20:55,382,975...55,391,252
Ensembl chr20:55,383,247...55,390,336
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EDN1
endothelin 1
ISO
CTD Direct Evidence: marker/mechanism Severe Persistent Allergic Asthma; protein:increased secretion:lung (human) DNA:transition:intron:g.4124T>C (human)
CTD RGD
PMID:11668616 PMID:16981460 PMID:20588001
RGD:4144869 RGD:4144895
NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383
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EDNRA
endothelin receptor type A
ISO
RGD
PMID:17448648 PMID:18632188
RGD:4892288 RGD:4892322
NCBI chr15:45,823,472...45,878,527
Ensembl chr15:45,823,560...45,876,463
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EDNRB
endothelin receptor type B
ISO
mRNA:increased expression:bronchus, smooth muscle cell DNA:polymorphism (human)
RGD
PMID:15245576 PMID:17470272 PMID:18632188
RGD:4892288 RGD:4892321 RGD:4892324
NCBI chr22:31,415,324...31,438,772
Ensembl chr22:31,417,308...31,437,587
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EGFR
epidermal growth factor receptor
severity
ISO
protein:increased expression:lung epithelium (rat) protein:increased expression:lung epithelium (mouse) protein:increased expression:bronchial epithelium (human)
RGD
PMID:12580917 PMID:19954006 PMID:21072743 PMID:21224214
RGD:5131468 RGD:5131633 RGD:5131642 RGD:5131870
NCBI chr18:5,983,669...6,044,092
Ensembl chr18:5,982,770...6,042,631
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EGR1
early growth response 1
ISO
DNA:snp:5' utr:g.-4071A>G rs7729723 (human) mRNA:increased expression:bronchoalveolar lavage cell (human)
RGD
PMID:11254538 PMID:18507785 PMID:18774390
RGD:5130915 RGD:5131985 RGD:5131993
NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575
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ELP1
elongator acetyltransferase complex subunit 1
no_association
ISO
RGD
PMID:11281413 PMID:12774215
RGD:5129157 RGD:5129158
NCBI chr11:64,035,667...64,094,402
Ensembl chr11:64,037,506...64,093,819
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EPHX1
epoxide hydrolase 1
susceptibility
ISO
DNA:SNPs:exons:p.Y113H (rs1051740), p.H139R (rs2234922) (human)
RGD
PMID:17711870
RGD:4889407
NCBI chr 7:38,964,319...39,004,902
Ensembl chr 7:38,964,338...38,999,238
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EPX
eosinophil peroxidase
severity disease_progression
ISO
protein:increased activity:sputum,nasal,pharyngeal mucosa
RGD
PMID:12199967 PMID:20813885 PMID:26645423
RGD:11574908 RGD:13506891 RGD:13506892
NCBI chr 9:32,855,568...32,865,445
Ensembl chr 9:32,855,507...32,865,022
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ESR2
estrogen receptor 2
ISO
mRNA:decreased expression:lung (rat)
RGD
PMID:18375789
RGD:8694127
NCBI chr 8:38,645,917...38,715,347
Ensembl chr 8:38,645,430...38,702,691
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F2
coagulation factor II, thrombin
ISO
associated with Rhinosinusitis, associated with Nasal Polyps;protein:increased expression:nasal mucus protein:increased expression:plasma
RGD
PMID:21658190 PMID:21711961
RGD:5147753 RGD:5147783
NCBI chr18:42,782,744...42,799,531
Ensembl chr18:42,782,751...42,799,459
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F2RL1
F2R like trypsin receptor 1
ISO
RGD
PMID:19864598
RGD:4892589
NCBI chr 3:29,801,119...29,810,006
Ensembl chr 3:29,800,211...29,810,180
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F7
coagulation factor VII
treatment
ISO
RGD
PMID:24523826
RGD:11040539
NCBI chr22:60,572,459...60,582,743
Ensembl chr22:60,571,822...60,597,024
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FAS
Fas cell surface death receptor
ISO
mRNA:increased expression:eosinophil
RGD
PMID:16337971
RGD:1600350
NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321
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FCER1A
Fc epsilon receptor Ia
severity
ISO
Asthma symptoms persistent despite steroids Fatal asthma subjects
RGD
PMID:20937062 PMID:21388666
RGD:5128711 RGD:5128717
NCBI chr38:22,683,478...22,688,842
Ensembl chr38:22,683,477...22,690,763
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FCGR2B
Fc fragment of IgG receptor IIb
ISO
RGD
PMID:20179765
RGD:11344929
NCBI chr38:20,980,777...20,994,403
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FGA
fibrinogen alpha chain
treatment
ISO
RGD
PMID:24523826
RGD:11040539
NCBI chr15:52,238,305...52,247,017
Ensembl chr15:52,236,198...52,246,975
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FKBP5
FKBP prolyl isomerase 5
ISO
ClinVar Annotator: match by term: Asthma
ClinVar
NCBI chr12:4,724,668...4,833,691
Ensembl chr12:4,727,497...4,833,323
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FOXP3
forkhead box P3
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:27633092 PMID:27965764 PMID:28944907 PMID:29317916
RGD:38548920 RGD:38549365
NCBI chr X:42,331,229...42,362,841
Ensembl chr X:42,344,108...42,350,758
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GATA3
GATA binding protein 3
ISO
RGD
PMID:9949310 PMID:18186587
RGD:5128802 RGD:5128803
NCBI chr 2:28,068,143...28,098,445
Ensembl chr 2:28,069,051...28,087,760
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GC
GC vitamin D binding protein
ISO
protein, mRNA:increased expression:bronchoalveolar lavage fluid:
RGD
PMID:21169467
RGD:5509920
NCBI chr13:60,795,305...60,828,038
Ensembl chr13:60,795,305...60,827,929
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GSDMB
gasdermin B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24241537
NCBI chr 9:22,604,358...22,616,540
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GSTM3
glutathione S-transferase mu 3
ISO
DNA:polymorphism
RGD
PMID:11470996 PMID:17550934
RGD:5135038 RGD:5135039
NCBI chr 6:42,187,869...42,191,274
Ensembl chr 6:42,187,967...42,191,273
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GSTO2
glutathione S-transferase omega 2
susceptibility
ISO
DNA:polymorphism:exon:p. N142D (human)
RGD
PMID:20374258
RGD:5490988
NCBI chr28:16,580,250...16,604,977
Ensembl chr28:16,586,777...16,604,976
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GSTP1
glutathione S-transferase pi 1
susceptibility severity no_association disease_progression
ISO
DNA:SNP: :p.A114V (human) CTD Direct Evidence: marker/mechanism DNA:SNPs:intron,exon:(rs749174), (rs1138272)(human) DNA:polymorphism:exon:p.I105V (rs1695) (human) DNA:SNPs:exons:p.I105V (rs1695), A114V (rs1138272) (human) DNA:SNPs: :p.I105V, p.A114V (human) DNA:polymorphism:exon:p.I105V (human)
RGD CTD
PMID:10806136 PMID:11994713 PMID:15693909 PMID:16176403 PMID:16870661 PMID:18057098 PMID:18709160 PMID:18787219 PMID:18988661 PMID:20210814 PMID:20858151 PMID:24117884 PMID:29411558 More...
RGD:4140946 RGD:4140947 RGD:4140951 RGD:4142519 RGD:4142526 RGD:5490985 RGD:5490991 RGD:5490999
NCBI chr18:49,905,161...49,908,182
Ensembl chr18:49,905,161...49,908,182
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HAVCR1
hepatitis A virus cellular receptor 1
ISO
RGD
PMID:20628202
RGD:5128851
NCBI chr 4:53,012,223...53,066,611
Ensembl chr 4:53,046,970...53,128,952 Ensembl chr 4:53,046,970...53,128,952
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HAVCR2
hepatitis A virus cellular receptor 2
ISO
RGD
PMID:17517968
RGD:5135525
NCBI chr 4:53,018,990...53,032,035
Ensembl chr 4:53,012,234...53,033,393
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HDAC2
histone deacetylase 2
ISO
mRNA:decreased expression:macrophage:
RGD
PMID:20538962
RGD:9590321
NCBI chr12:70,053,822...70,083,491
Ensembl chr12:70,053,297...70,103,578
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HDC
histidine decarboxylase
ISO
associated with Rhinitis;DNA:SNP: :p.E644D (rs2073440) (human)
RGD
PMID:20608921
RGD:5128884
NCBI chr30:16,201,222...16,223,452
Ensembl chr30:16,201,589...16,223,662
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HIF1A
hypoxia inducible factor 1 subunit alpha
treatment
ISO
RGD
PMID:18160846
RGD:10402541
NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692
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HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
ISO
RGD
PMID:20084838
RGD:5508450
NCBI chr 3:30,970,037...30,988,987
Ensembl chr 3:30,970,037...30,990,294
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HMOX1
heme oxygenase 1
severity
ISO
mRNA;protein:increased expression:Leukocytes, Mononuclear CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16196283 PMID:18048809 PMID:20596599
RGD:4145403 RGD:4145408
NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773
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HNMT
histamine N-methyltransferase
no_association susceptibility
ISO
ClinVar Annotator: match by term: Asthma, susceptibility to | ClinVar Annotator: match by term: HNMT-related condition
RGD OMIM ClinVar
PMID:10752634 PMID:10803682 PMID:15693910 PMID:16205835 PMID:17651147 PMID:25741868 PMID:28492532 More...
RGD:5128885 RGD:5128887 RGD:5128888
NCBI chr19:40,656,266...40,702,498
Ensembl chr19:40,655,161...40,702,218
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HSD11B2
hydroxysteroid 11-beta dehydrogenase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11932298
NCBI chr 5:81,966,397...81,970,301
Ensembl chr 5:81,966,937...81,968,991
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HTR2A
5-hydroxytryptamine receptor 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25322896
NCBI chr22:4,453,715...4,510,934
Ensembl chr22:4,453,715...4,511,037
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ICAM1
intercellular adhesion molecule 1
ISO
mRNA:increased expression:aorta (mouse) protein:increased expression:lung, serum (rat) CTD Direct Evidence: marker/mechanism protein:increased secretion:lung (human)
RGD CTD
PMID:17014439 PMID:20205697 PMID:20400685 PMID:20953388 PMID:25003170
RGD:4145331 RGD:4145444 RGD:4145509
NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914
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IFNG
interferon gamma
resistance treatment
ISO
protein:increased expression:sputum
RGD
PMID:12396623 PMID:19542437 PMID:20817868 PMID:20953328
RGD:10755706 RGD:4145525 RGD:4145651 RGD:5128479
NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698
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IFNGR1
interferon gamma receptor 1
ISO
DNA: SNP: Leu467Pro
RGD
PMID:12851715 PMID:21737883
RGD:6480255 RGD:6480431
NCBI chr 1:29,646,776...29,669,669
Ensembl chr 1:29,647,552...29,669,578
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IFNL3
interferon lambda 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22295096
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IKZF3
IKAROS family zinc finger 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25256354
NCBI chr 9:22,643,482...22,733,988
Ensembl chr 9:22,643,640...22,728,385
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IL10
interleukin 10
treatment susceptibility
ISO
CTD Direct Evidence: marker/mechanism protein:decreased expression:plasma DNA:polymorphism: :-627C>A (human)
RGD CTD
PMID:12938145 PMID:20121766 PMID:20230687 PMID:20237464 PMID:20560982 PMID:20644177 PMID:21998459 PMID:29317916 More...
RGD:11046261 RGD:4140421 RGD:4140451 RGD:4140459 RGD:4140471 RGD:4143221 RGD:5131623
NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057
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IL12A
interleukin 12A
ISO
RGD
PMID:17056578 PMID:17548618
RGD:4373570 RGD:4438438
NCBI chr34:26,125,529...26,133,546
Ensembl chr34:26,124,770...26,133,550
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IL12B
interleukin 12B
susceptibility severity
ISO
DNA:polymorphisms:promoter, 3'utr: ClinVar Annotator: match by term: Asthma, susceptibility to DNA:polymorphisms:introns: DNA:polymorphism:promoter
RGD ClinVar
PMID:12241719 PMID:15322986 PMID:16210052
RGD:1600043 RGD:4145428 RGD:4145438
NCBI chr 4:51,178,637...51,194,606
Ensembl chr 4:51,183,568...51,193,228
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IL13
interleukin 13
susceptibility severity no_association
ISO
ClinVar Annotator: match by term: Asthma, susceptibility to DNA:polymorphism:cds:p.R130Q (human) protein:increased expression:sputum protein:increased expression:serum DNA:polymorphism: :c.-1055C>T (human)
OMIM ClinVar RGD
PMID:10699178 PMID:11588017 PMID:11678850 PMID:11709756 PMID:11758895 PMID:12847555 PMID:12928861 PMID:15356556 PMID:15483090 PMID:15711639 PMID:15879126 PMID:18258919 PMID:18328894 PMID:20198887 More...
RGD:4145593 RGD:4145639 RGD:4145777 RGD:4763153 RGD:4763761
NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388
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IL13RA1
interleukin 13 receptor subunit alpha 1
no_association
ISO
DNA:polymorphism: :1050C>T (human) mRNA:increased expression:bronchus DNA:polymorphism: :1398A>G (human) DNA:polymorphisms:promoter, 3' utr:-281T>G, 1365A>G (human)
RGD
PMID:10686479 PMID:11714828 PMID:17006604 PMID:17392323 PMID:18480254 PMID:20383033 More...
RGD:4892639 RGD:4892646 RGD:4892647 RGD:4892650 RGD:4892654 RGD:4892655
NCBI chr X:90,925,497...90,981,855
Ensembl chr X:90,924,801...90,979,963
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IL13RA2
interleukin 13 receptor subunit alpha 2
ISO
mRNA:increased expression:bronchus protein:increased expression:serum
RGD
PMID:17885690 PMID:20383033 PMID:21462799
RGD:4892646 RGD:4892649 RGD:8549521
NCBI chr X:87,747,373...87,776,797
Ensembl chr X:87,747,373...87,776,798
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IL15
interleukin 15
no_association
ISO
DNA:SNPs: :multiple (human)
RGD
PMID:11160248 PMID:15131572 PMID:15843549 PMID:16629787 PMID:19133918
RGD:4984421 RGD:4990462 RGD:5000757 RGD:5000758 RGD:5000760
NCBI chr19:1,339,607...1,364,762
Ensembl chr19:1,339,967...1,364,762
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IL16
interleukin 16
no_association severity
ISO
associated with Rhinitis;protein:increased expression:respiratory system fluid/secretion DNA:SNP:promoter:-295T>C (human) protein:increased expression:serum
RGD
PMID:10585533 PMID:12872394 PMID:15784111 PMID:16387589 PMID:16734115
RGD:5024928 RGD:5024930 RGD:5024934 RGD:5024935 RGD:5024937
NCBI chr 3:56,473,485...56,575,504
Ensembl chr 3:56,473,486...56,575,104
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IL17A
interleukin 17A
susceptibility
ISO
mRNA,protein:increased expression:Leukocytes, Mononuclear, lung, serum DNA:SNP:promoter:rs2275913 (human) protein:increased expression:alveolar macrophage protein:increased expression:sputum
RGD
PMID:15730730 PMID:18060619 PMID:18941201 PMID:20351038 PMID:20437253
RGD:4839043 RGD:4888527 RGD:4889114 RGD:4889139 RGD:4889152
NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513
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IL17RB
interleukin 17 receptor B
ISO
associated with Picornaviridae Infections
RGD
PMID:25273095
RGD:39128256
NCBI chr20:36,135,620...36,148,923
Ensembl chr20:36,135,619...36,148,490
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IL18
interleukin 18
susceptibility severity disease_progression
ISO
DNA:SNP:promoter:c.and -137G>C (rs187238)(human) DNA:SNP:promoter: c.-380C>G (rs5744247)(human) DNA:SNPs:Promoter:c. -607C>A (rs1946518), -137G/C (rs187238) (human) DNA:polymorphism: :c. -105A>C (human) protein:increased expression:serum
RGD
PMID:11174201 PMID:16433859 PMID:17767553 PMID:18200581 PMID:18826499 PMID:19745201 PMID:20497957 More...
RGD:4889585 RGD:4889863 RGD:4889898 RGD:4889900 RGD:4889908 RGD:4889910 RGD:4889923
NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348
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IL18R1
interleukin 18 receptor 1
ISO
DNA:SNPs: :multiple (human) DNA:SNP: :rs3771166 (human)
RGD
PMID:11972614 PMID:18382474 PMID:18774397 PMID:19910030 PMID:20860503
RGD:5024942 RGD:5024945 RGD:5024946 RGD:5024947 RGD:5024948
NCBI chr10:40,614,336...40,653,300
Ensembl chr10:40,615,312...40,653,454
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IL19
interleukin 19
ISO
mRNA, protein:increased expression:lung, serum protein:increased expression:serum
RGD
PMID:15557163
RGD:5037236
NCBI chr 7:6,000,994...6,006,959
Ensembl chr 7:6,000,907...6,006,870
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IL1A
interleukin 1 alpha
ISO
DNA:polymorphisms: :
RGD
PMID:18763028
RGD:4142802
NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435
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IL1B
interleukin 1 beta
susceptibility
ISO
CTD Direct Evidence: marker/mechanism protein:decreased expression:neutrophil DNA:polymorphism: :-511C>T (human)
CTD RGD
PMID:9176529 PMID:18926055 PMID:19684087 PMID:19842845
RGD:4142830 RGD:4142836 RGD:4142864
NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458
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IL1RL1
interleukin 1 receptor like 1
susceptibility severity
ISO
protein:increased expression:serum DNA:SNP: :rs1420101 (human) DNA:SNP: :rs10197862 (human) DNA:SNPs:intron:rs1420089, rs1861245,rs1946131 (human) DNA:SNP: :rs1041973 (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:11463601 PMID:17407196 PMID:17623648 PMID:19179489 PMID:19198610 PMID:19852851 PMID:21150878 PMID:21281963 PMID:21804549 PMID:24241537 PMID:27472835 More...
RGD:5144235 RGD:5144237 RGD:5144239 RGD:5144240 RGD:5144242 RGD:5144243 RGD:5144244 RGD:5144245
NCBI chr10:40,658,191...40,732,097
Ensembl chr10:40,659,041...40,677,357
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IL1RN
interleukin 1 receptor antagonist
susceptibility severity
ISO
DNA:SNPs: :rs447713, rs3087271 (human) DNA, protein:repeat, decreased expression (human) protein:increased expression:plasma DNA:SNPs: :multiple (human) DNA:SNP: :rs2234678 (human) CTD Direct Evidence: marker/mechanism DNA:polymorphism:intron (human)
RGD CTD
PMID:9176529 PMID:10843772 PMID:11027520 PMID:15020290 PMID:16409203 PMID:16724092 PMID:17107994 PMID:18763028 PMID:18926055 More...
RGD:4142802 RGD:4142864 RGD:4143163 RGD:4143208 RGD:4143209 RGD:4143216 RGD:4143224 RGD:4143225
NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329
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IL2
interleukin 2
susceptibility
ISO
DNA:SNP:promoter:rs2069762(human)
RGD
PMID:16333313 PMID:20926789
RGD:4889118 RGD:8663473
NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394
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IL21
interleukin 21
ISO
DNA:SNP:exon:5250C>T (human)
RGD
PMID:18802358
RGD:5147396
NCBI chr19:17,641,833...17,651,275
Ensembl chr19:17,641,833...17,651,266
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IL22
interleukin 22
severity treatment
ISO
mRNA:increased expression:blood, mononuclear cell protein:increased expression:serum
RGD
PMID:21297073 PMID:21535180 PMID:21998459
RGD:11046261 RGD:5147403 RGD:5147409
NCBI chr10:10,487,367...10,492,238
Ensembl chr10:10,487,262...10,492,371
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IL23R
interleukin 23 receptor
ISO
RGD
PMID:19935773
RGD:5037240
NCBI chr 5:43,307,422...43,369,806
Ensembl chr 5:43,308,982...43,368,474
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IL25
interleukin 25
ISO
mRNA, protein:increased expression:lung
RGD
PMID:25273095
RGD:39128256
NCBI chr 8:3,621,268...3,624,689
Ensembl chr 8:3,618,161...3,624,043
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IL27
interleukin 27
treatment susceptibility
ISO
protein:increased expression:sputum DNA:SNP: :g.-964A>G (human)
RGD
PMID:17318299 PMID:17878337 PMID:19542437 PMID:20817868 PMID:26595888
RGD:11076728 RGD:4145651 RGD:5128479 RGD:5128485 RGD:5128491
NCBI chr 6:18,243,988...18,248,369
Ensembl chr 6:18,244,040...18,247,635
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IL27RA
interleukin 27 receptor subunit alpha
ISO
RGD
PMID:16081811
RGD:5128496
NCBI chr20:48,456,766...48,475,414
Ensembl chr20:48,457,134...48,472,450
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IL29L
interleukin 29-like
exacerbates
ISO
associated with common cold;protein:increased expression: nasal cavity (human) associated with common cold;mRNA:decreased expression:sputum (human)
RGD
PMID:22135341 PMID:25784275
RGD:126848770 RGD:126848775
NCBI chr24:36,440,445...36,441,017
Ensembl chr24:36,440,445...36,441,017
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IL2RA
interleukin 2 receptor subunit alpha
ISO
RGD
PMID:17351063 PMID:20525707 PMID:21377197
RGD:2325990 RGD:5147437 RGD:5147445
NCBI chr 2:29,892,130...29,948,926
Ensembl chr 2:29,894,125...29,944,643
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IL2RB
interleukin 2 receptor subunit beta
ISO
DNA:SNP: :rs2284033 (human)
RGD
PMID:18641329 PMID:20860503
RGD:5024942 RGD:5147447
NCBI chr10:27,370,797...27,388,775
Ensembl chr10:27,370,797...27,388,775
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IL3
interleukin 3
susceptibility
ISO
DNA:polymorphism:cds:+79T>C(S27P)(human) DNA:SNP: :rs40401(human)
RGD
PMID:15372320 PMID:24684517
RGD:13506914 RGD:13506916
NCBI chr11:20,330,480...20,332,668
Ensembl chr11:20,330,480...20,332,668
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IL32
interleukin 32
ISO
protein:increased expression:blood serum (human)
RGD
PMID:22336080
RGD:150340749
NCBI chr 6:38,119,287...38,122,979
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IL33
interleukin 33
treatment severity
ISO
CTD Direct Evidence: marker/mechanism associated with viral pneumonia; associated with fungal infectious disease
CTD RGD
PMID:19198610 PMID:21804549 PMID:24241537 PMID:25746970 PMID:27472835 PMID:28947081 PMID:29067999 More...
RGD:39938968 RGD:39939002
NCBI chr11:27,219,878...27,256,723
Ensembl chr11:27,219,878...27,256,721
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IL4
interleukin 4
treatment no_association
ISO
mRNA, protein:increase expression:leukocyte, serum protein:increased expression:respiratory system fluid/secretion DNA:polymorphism (human) DNA:SNP: :589C>T (human) CTD Direct Evidence: marker/mechanism protein:increased expression:lung mRNA:increased expression:lung, spleen
RGD CTD
PMID:18211752 PMID:18357729 PMID:20524005 PMID:21103062 PMID:21354484 PMID:21364926 PMID:21375458 PMID:24450480 PMID:24946644 More...
RGD:10402791 RGD:10402799 RGD:2317290 RGD:4889866 RGD:5128500 RGD:5128502 RGD:5128557 RGD:5128560
NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534
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IL4R
interleukin 4 receptor
disease_progression susceptibility severity
ISO
OMIM:600807 DNA:SNPs:cds:p.E375A, Q551R (human) DNA:polymorphism::-1902G/A (human) DNA:SNPs: :multiple DNA:mutation:cds:p.Q576R (mouse) DNA:polymorphism:cds:p.Q551R (human) DNA:polymorphism:promoter:c.-3223C>T (human) DNA:SNPs:cds:p. I75V, Q576R (human) DNA:polymorphism:cds:p.I50V (human) DNA:polymorphism:cds:p.Q576R (human) DNA:polymorphism:cds:p. S478P (human)
RGD MouseDO
PMID:11398072 PMID:11709756 PMID:12133990 PMID:12940513 PMID:15479272 PMID:16917945 PMID:17170387 PMID:17586032 PMID:17823973 PMID:18425216 PMID:19770271 PMID:20605987 PMID:20868478 PMID:20953944 More...
RGD:4890003 RGD:4890024 RGD:4890346 RGD:4890347 RGD:4890348 RGD:4890349 RGD:4890351 RGD:4890352 RGD:4890387 RGD:4890402 RGD:4890404 RGD:4890406 RGD:5128514 RGD:5128553
NCBI chr 6:19,254,183...19,280,973
Ensembl chr 6:19,254,487...19,389,291
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IL5
interleukin 5
treatment disease_progression
ISO
DNA:polymorphism:promoter:-703C>T (human) protein: increased levels: sputum CTD Direct Evidence: marker/mechanism protein:increased expression:lungs, respiratory system fluid/secretion protein:increased expression:respiratory system fluid/secretion
RGD CTD
PMID:7540862 PMID:9182686 PMID:9493449 PMID:11159041 PMID:15502111 PMID:15626484 PMID:17074272 PMID:18629290 PMID:19947994 PMID:22085848 PMID:22186238 PMID:23266719 PMID:25008888 More...
RGD:11354973 RGD:4145461 RGD:4890938 RGD:4890940 RGD:4890947 RGD:4890948 RGD:4890962 RGD:4890963 RGD:5687140 RGD:5687144 RGD:5687189
NCBI chr11:20,825,469...20,827,269
Ensembl chr11:20,825,469...20,827,269
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IL5RA
interleukin 5 receptor subunit alpha
ISO
DNA:SNP: :c.25091G>A (human) DNA:SNPs (human)
RGD
PMID:10224351 PMID:10848907 PMID:16217591 PMID:17276963 PMID:20513521 PMID:20592918 More...
RGD:5128614 RGD:5128617 RGD:5128623 RGD:5128625 RGD:5128626 RGD:5128627
NCBI chr20:14,309,805...14,349,433
Ensembl chr20:14,314,227...14,343,793
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IL6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:lung associated with Hypersensitivity;protein:increased expression:sputum
CTD RGD
PMID:20658762 PMID:20816188 PMID:20840469 PMID:21115736 PMID:29902480
RGD:4143265 RGD:4143266 RGD:4143271 RGD:5128630
NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519
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IL6R
interleukin 6 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:17496315 PMID:21115736 PMID:29902480
RGD:5128630 RGD:5128662
NCBI chr 7:42,877,731...42,920,149
Ensembl chr 7:42,880,885...42,920,090
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IL9
interleukin 9
ISO
protein:increased expression:sputum, macrophage, cytoplasm protein:increased expression:respiratory system fluid/secretion
RGD
PMID:12153980 PMID:15303135 PMID:15531759 PMID:17446528 PMID:21356110
RGD:5128686 RGD:5128690 RGD:5128691 RGD:5128700 RGD:5128707
NCBI chr11:23,808,919...23,814,085
Ensembl chr11:23,811,117...23,814,079
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IRAK3
interleukin 1 receptor associated kinase 3
susceptibility
ISO
ClinVar Annotator: match by term: Asthma-related traits, susceptibility to, 5 | ClinVar Annotator: match by term: IRAK3-related condition
OMIM ClinVar
PMID:17503328 PMID:25741868 PMID:28492532
NCBI chr10:8,683,541...8,730,757
Ensembl chr10:8,684,242...8,729,268
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IRF1
interferon regulatory factor 1
susceptibility no_association
ISO
protein:increased expression:respiratory tract epithelium DNA:repeat:intron (human) DNA:polymorphisms:promoter, cds:-300G>T, 4396A>G, 6355G>A (human)
RGD
PMID:10225979 PMID:11069564 PMID:16961714
RGD:5128723 RGD:5128724 RGD:5128726
NCBI chr11:20,773,801...20,781,106
Ensembl chr11:20,760,120...20,781,608
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IRF3
interferon regulatory factor 3
ISO
RGD
PMID:20673978
RGD:5128793
NCBI chr 1:106,875,016...106,879,065
Ensembl chr 1:106,875,118...106,879,065
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ITGB3
integrin subunit beta 3
ISO
DNA:SNPs: :
RGD
PMID:17556058
RGD:5037230
NCBI chr 9:9,179,667...9,231,061
Ensembl chr 9:9,182,562...9,231,451
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ITGB6
integrin subunit beta 6
ISO
OMIM:600807
MouseDO
NCBI chr36:5,833,206...5,962,699
Ensembl chr36:5,834,638...5,962,633
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ITPR1
inositol 1,4,5-trisphosphate receptor type 1
ISO
RGD
PMID:21777465
RGD:5147661
NCBI chr20:12,746,171...13,065,256
Ensembl chr20:12,747,315...13,064,198
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KDR
kinase insert domain receptor
ISO
associated with Rhinitis,Allergic,Seasonal;protein:increased expression:nasal cavity of mucosa:
RGD
PMID:17651148 PMID:20921519
RGD:5684385 RGD:8551771
NCBI chr13:47,442,861...47,484,574
Ensembl chr13:47,442,764...47,485,042
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KIF3A
kinesin family member 3A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21912604
NCBI chr11:20,988,516...21,044,151
Ensembl chr11:20,928,655...21,044,090
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KRT19
keratin 19
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15478392
NCBI chr 9:21,240,778...21,245,039
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LEP
leptin
ISO
protein:increased expression:plasma
RGD
PMID:19705789
RGD:5128781
NCBI chr14:8,115,396...8,130,946
Ensembl chr14:8,116,122...8,131,395
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LGALS3
galectin 3
treatment
ISO
RGD
PMID:16424226
RGD:9685213
NCBI chr 8:30,977,438...30,994,711
Ensembl chr 8:30,983,633...30,994,705
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LOC102156778
bone marrow proteoglycan-like
severity disease_progression no_association
ISO
mRNA:increased expression:eosinophil: associated with viral infection;mRNA:increased expression:sputum: associated with cough;protein:increased expression:sputum:
RGD
PMID:11067904 PMID:16982448 PMID:22022864 PMID:24450586
RGD:13506941 RGD:13506942 RGD:13506943 RGD:13506944
NCBI chr18:38,753,269...38,760,730
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LOC106557449
alveolar macrophage chemotactic factor-like
ISO
mRNA:increased expression:bronchus epithelium
RGD
PMID:17234659
RGD:5135243
NCBI chr13:62,514,244...62,516,439
Ensembl chr13:62,513,898...62,515,218
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LOC478984
low affinity immunoglobulin gamma Fc region receptor III
susceptibility
ISO
DNA:polymorphism:exon:p.F158V(rs396991)(human)
RGD
PMID:18199088
RGD:5508449
NCBI chr38:21,054,870...21,060,948
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LOC610540
pulmonary surfactant-associated protein A-like
ISO
protein:decreased expression:lung mRNA, protein:increased expression:lung protein:decreased expression:lung, Clara cell, pneumocyte
RGD
PMID:15816355 PMID:16629790 PMID:18802356 PMID:18926058
RGD:4143289 RGD:4143398 RGD:4143462 RGD:4143516
NCBI chr 4:29,430,139...29,434,640
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LOC611642
interleukin-9 receptor
ISO
RGD
PMID:10629460
RGD:5128704
NCBI chr 6:40,425,072...40,437,917
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LTA
lymphotoxin alpha
susceptibility no_association
ISO
DNA:polymorphism:intron DNA:polymorphisms:promoter
RGD
PMID:12530118 PMID:15969671 PMID:17536219 PMID:18947013
RGD:4143254 RGD:4143370 RGD:4143371 RGD:4143373
NCBI chr12:1,070,608...1,073,053
Ensembl chr12:1,071,192...1,073,067
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LTA4H
leukotriene A4 hydrolase
ISO
mRNA:increased expression:lung, cerebral cortex (rat)
RGD
PMID:15715933
RGD:2316607
NCBI chr15:35,795,934...35,830,681
Ensembl chr15:35,795,979...35,830,844
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MBL1
mannose binding lectin 1
susceptibility
ISO
DNA:SNP:cds:p.G54D(human) associated with Bronchiolitis;DNA:polymorphism:exon:
RGD
PMID:22512728 PMID:22674410
RGD:12910828 RGD:8693709
NCBI chr 4:29,419,886...29,424,377
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MEFV
MEFV innate immunity regulator, pyrin
susceptibility
ISO
DNA:mutations:exons
RGD
PMID:18219832
RGD:5129186
NCBI chr 6:37,964,776...37,984,830
Ensembl chr 6:37,970,608...37,983,737
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MIF
macrophage migration inhibitory factor
severity
ISO
protein:increased expression:bronchoalveolar lavage fluid DNA:repeats:promoter DNA:SNP:promoter:rs755622(human)
RGD
PMID:9637721 PMID:16186482 PMID:16455830 PMID:17373669 PMID:19317738
RGD:1641985 RGD:4891035 RGD:4891043 RGD:4891052 RGD:4891059
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MMP1
matrix metallopeptidase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24469321
NCBI chr 5:28,978,385...28,986,644
Ensembl chr 5:28,978,473...28,986,648
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MMP9
matrix metallopeptidase 9
ISO
DNA:SNP: : rs2664538(human) protein:increased expression:lung protein:increased expression:serum mRNA, protein:increased expression:lung CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:11742282 PMID:15131573 PMID:16191269 PMID:19361849 PMID:19940022 PMID:20181264 PMID:21439806 More...
RGD:2325953 RGD:5129204 RGD:5129522 RGD:5129687 RGD:5130859
NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293
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MPO
myeloperoxidase
susceptibility
ISO
protein:increased expression:serum DNA:polymorphism: :−463G > A (human)
RGD
PMID:10731862 PMID:19544176
RGD:5130989 RGD:5130994
NCBI chr 9:32,927,483...32,938,007
Ensembl chr 9:32,927,483...32,937,820
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MS4A2
membrane spanning 4-domains A2
susceptibility
ISO
DNA:SNP: : -109C>T (human) Atopy and bronchial hyperresponsiveness, OMIM:147050 DNA:polymorphism:CDS:amino acid E237G DNA:SNPs:multiple:, rs573790, rs2583476, rs569108 DNA:SNPs: : rs556917, rs502581, rs502419 (human)
RGD
PMID:8817330 PMID:19218813 PMID:19862939 PMID:21320344
RGD:1599903 RGD:5131092 RGD:5131149 RGD:5131151
NCBI chr21:50,439,133...50,456,785
Ensembl chr21:50,450,024...50,456,785
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MTHFR
methylenetetrahydrofolate reductase
ISO
DNA:transition:cds:g.677C>T (human)
RGD
PMID:20456312
RGD:4891145
NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818
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MUC1
mucin 1, cell surface associated
ISO
protein:increased expression:serum
RGD
PMID:11802251
RGD:5131281
NCBI chr 7:42,338,939...42,344,690
Ensembl chr 7:42,340,375...42,344,690
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MUC2
mucin 2, oligomeric mucus/gel-forming
ISO
associated with hypersensitivity
RGD
PMID:11062147 PMID:14594655
RGD:5131178 RGD:7349354
NCBI chr18:45,416,347...45,438,226
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MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
treatment
ISO
mRNA,protein:increased expression:lung mRNA, protein:increased expression:lung
RGD
PMID:14594655 PMID:17590487 PMID:17698377 PMID:21549818 PMID:21780541
RGD:2324962 RGD:5131204 RGD:7349354 RGD:7349407 RGD:7364729
NCBI chr18:45,471,232...45,498,961
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MUC5B
mucin 5B, oligomeric mucus/gel-forming
ISO
protein:altered expression:sputum
RGD
PMID:11587997 PMID:11802783
RGD:5131252 RGD:7364763
NCBI chr18:45,517,479...45,545,765
Ensembl chr18:45,517,474...45,545,184
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MUC7
mucin 7, secreted
ISO
ClinVar Annotator: match by term: Asthma, protection against
ClinVar OMIM
PMID:11378823 PMID:16759176 PMID:28492532
NCBI chr13:59,805,768...59,813,415
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MYB
MYB proto-oncogene, transcription factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19198610
NCBI chr 1:27,908,309...27,991,984
Ensembl chr 1:27,908,364...27,991,969
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MYD88
MYD88 innate immune signal transduction adaptor
ameliorates
ISO
RGD
PMID:26882889
RGD:11531666
NCBI chr23:7,901,578...7,905,274
Ensembl chr23:7,901,250...7,904,534
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MYLK
myosin light chain kinase
ISO
RGD
PMID:17472811
RGD:4891492
NCBI chr33:26,663,991...26,867,370
Ensembl chr33:26,664,800...26,843,181
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NFE2L2
NFE2 like bZIP transcription factor 2
severity
ISO
mRNA:increased expression:bronchoalveolar lavage cell, peripheral blood mononuclear cell (human)
RGD
PMID:21514635
RGD:6893376
NCBI chr36:20,989,205...21,087,044
Ensembl chr36:20,989,360...21,012,524
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NGF
nerve growth factor
severity
ISO
protein:increased expression:lung, serum protein:increased expression:blood, eosinophil
RGD
PMID:11737043 PMID:12752594 PMID:17164945 PMID:17497413
RGD:4891068 RGD:4891108 RGD:4891122 RGD:4891123
NCBI chr17:52,900,647...52,901,607
Ensembl chr17:52,900,647...52,901,607
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NGFR
nerve growth factor receptor
ISO
RGD
PMID:12540484 PMID:16603479
RGD:5144070 RGD:5144072
NCBI chr 9:25,598,468...25,621,021
Ensembl chr 9:25,601,074...25,623,274
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NOD1
nucleotide binding oligomerization domain containing 1
susceptibility
ISO
DNA:SNP: :rs2075817 (human) DNA:insertion:cds:
RGD
PMID:15718249 PMID:16918516
RGD:5131518 RGD:5131519
NCBI chr14:43,162,671...43,226,948
Ensembl chr14:43,163,571...43,227,103
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NOD2
nucleotide binding oligomerization domain containing 2
susceptibility
ISO
DNA:polymorphisms:intron, exon/3'UTR (rs1077861, rs3135500) (human)
RGD
PMID:16008671 PMID:21051079
RGD:5131477 RGD:5508757
NCBI chr 2:64,636,850...64,667,232
Ensembl chr 2:64,635,519...64,667,232
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NOS1
nitric oxide synthase 1
susceptibility
ISO
DNA:repeats:intron DNA:repeats:exon DNA:repeats: :
RGD
PMID:10673365 PMID:10833424 PMID:14767694 PMID:20609134
RGD:5132615 RGD:5132860 RGD:5132863 RGD:5132869
NCBI chr26:13,787,341...13,895,176
Ensembl chr26:13,786,309...13,962,332
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NOS2
nitric oxide synthase 2
severity no_association disease_progression
ISO
mRNA:increased expression:monocyte CTD Direct Evidence: marker/mechanism DNA:repeats:promoter, introns (human) protein:increased expression, increased activity:lung (rat) associated with Rhinitis, Allergic, Seasonal; protein:increased expression:nasal mucosa DNA:repeat:promoter DNA:SNP:exon:p.S608L (human) protein:increased expression:lung, bronchoalveolar lavage fluid
RGD CTD
PMID:16540403 PMID:16703578 PMID:17161822 PMID:17177683 PMID:17189532 PMID:18254476 PMID:18714530 PMID:19800904 PMID:20841959 PMID:20842520 PMID:21847581 More...
RGD:4891419 RGD:4891480 RGD:4891508 RGD:4891910 RGD:4891924 RGD:4891925 RGD:4891927 RGD:4891953 RGD:4891957 RGD:5509073
NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588
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NOS3
nitric oxide synthase 3
susceptibility
ISO
DNA:snps, repeat, haplotype:promoter, introns, exons:multiple (human) DNA:repeats:intron DNA:polymorphisms:promoter:c. -786C>T, -691C>T (human)
RGD
PMID:16081038 PMID:16837812 PMID:18486767
RGD:4892053 RGD:4892058 RGD:4892062
NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
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NPSR1
neuropeptide S receptor 1
susceptibility
ISO
ClinVar Annotator: match by term: Asthma-related traits, susceptibility to, 2
OMIM ClinVar
PMID:15073379
NCBI chr14:46,465,169...46,610,256
Ensembl chr14:46,466,544...46,609,477
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NPY
neuropeptide Y
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9731035
NCBI chr14:37,824,579...37,831,289
Ensembl chr14:37,823,861...37,831,443
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NQO1
NAD(P)H quinone dehydrogenase 1
susceptibility
ISO
DNA:SNP:exon:c.609C>T (human) CTD Direct Evidence: marker/mechanism DNA:SNP:exon:c. 609C>T (human)
RGD CTD
PMID:19027876 PMID:19591959 PMID:20049212
RGD:5135005 RGD:5135006
NCBI chr 5:79,979,593...79,990,875
Ensembl chr 5:79,978,865...79,989,860
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NR3C1
nuclear receptor subfamily 3 group C member 1
treatment severity susceptibility
ISO
protein:increased expression, decreased activity:leukocyte, mononuclear DNA:polymorphism:intron
RGD
PMID:15295049 PMID:18396779 PMID:18799869 PMID:20727335 PMID:21113676 PMID:28297812 More...
RGD:408364991 RGD:4892328 RGD:4892568 RGD:4892594 RGD:4892609 RGD:7174728
NCBI chr 2:38,124,568...38,242,510
Ensembl chr 2:38,123,190...38,240,755
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NTF3
neurotrophin 3
ISO
protein:increased expression:lung, serum
RGD
PMID:11737043 PMID:17497413
RGD:4891068 RGD:4891123
NCBI chr27:39,383,017...39,454,613
Ensembl chr27:39,383,152...39,454,601
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NTF4
neurotrophin 4
ISO
protein:increased expression:lung, serum
RGD
PMID:17497413
RGD:4891068
NCBI chr 1:107,371,335...107,377,238
Ensembl chr 1:107,371,335...107,376,987
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NTRK1
neurotrophic receptor tyrosine kinase 1
ISO
mRNA:increased expression:lung:
RGD
PMID:16708804 PMID:20934630
RGD:5684766 RGD:5684772
NCBI chr 7:41,140,931...41,159,326
Ensembl chr 7:41,140,879...41,159,288
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ORMDL3
ORMDL sphingolipid biosynthesis regulator 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21150878 PMID:25256354
NCBI chr 9:22,594,425...22,601,108
Ensembl chr 9:22,594,480...22,599,999
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P2RY12
purinergic receptor P2Y12
ISO
RGD
PMID:19822647 PMID:22010907
RGD:6480532 RGD:6480533
NCBI chr23:45,908,574...45,954,675
Ensembl chr23:45,909,485...45,910,526
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PARP1
poly(ADP-ribose) polymerase 1
treatment
ISO
protein:increased activation:lung, blood, mononuclear cell CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12594058 PMID:18261157 PMID:26205779
RGD:11073727 RGD:5683910
NCBI chr 7:38,503,072...38,542,556
Ensembl chr 7:38,503,067...38,542,127
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PDCD1
programmed cell death 1
treatment
ISO
associated with Chlamydia pneumonia
RGD
PMID:26378990
RGD:41412180
NCBI chr25:51,606,559...51,618,903
Ensembl chr25:51,608,173...51,618,723
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PDE4B
phosphodiesterase 4B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21912604
NCBI chr 5:44,063,145...44,606,070
Ensembl chr 5:44,065,106...44,500,999
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PDE4D
phosphodiesterase 4D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19426955 PMID:21611147
NCBI chr 2:45,843,767...47,245,263
Ensembl chr 2:45,846,294...46,949,912
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PDGFB
platelet derived growth factor subunit B
ISO
protein: increased expression
RGD
PMID:21216974
RGD:6483071
NCBI chr10:25,798,877...25,819,422
Ensembl chr10:25,798,938...25,817,746
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PGF
placental growth factor
ISO
RGD
PMID:22268141
RGD:6483605
NCBI chr 8:48,059,554...48,110,534
Ensembl chr 8:48,059,552...48,075,170
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PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
ISO
RGD
PMID:18754810
RGD:6482695
NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
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PIN1
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
ISO
RGD
PMID:18188456
RGD:8693422
NCBI chr20:51,156,887...51,168,131
Ensembl chr20:51,157,121...51,168,136
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PLA2G4A
phospholipase A2 group IVA
ISO
RGD
PMID:15557087
RGD:1642462
NCBI chr 7:19,804,412...19,955,215
Ensembl chr 7:19,832,664...19,966,936
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PLA2G7
phospholipase A2 group VII
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:10733466
RGD:1581025
NCBI chr12:14,866,229...14,908,230
Ensembl chr12:14,866,229...14,908,114
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PLAU
plasminogen activator, urokinase
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:18519237 PMID:21912604
RGD:4892037
NCBI chr 4:24,329,139...24,333,893
Ensembl chr 4:24,328,925...24,334,851
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PPP2CA
protein phosphatase 2 catalytic subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22205926
NCBI chr11:22,388,327...22,410,052
Ensembl chr11:22,385,257...22,410,052
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PRF1
perforin 1
ISO
RGD
PMID:21426642 PMID:22250087
RGD:6482815 RGD:6482818
NCBI chr 4:21,497,865...21,502,429
Ensembl chr 4:21,498,249...21,500,864
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PRMT1
protein arginine methyltransferase 1
ISO
mRNA:increased expression:lung
RGD
PMID:20423833
RGD:9491823
NCBI chr 1:106,849,864...106,859,896
Ensembl chr 1:106,849,864...106,874,075
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PRMT2
protein arginine methyltransferase 2
ISO
mRNA:increased expression:lung, spleen
RGD
PMID:20423833
RGD:9491823
NCBI chr31:39,806,086...39,838,959
Ensembl chr31:39,807,593...39,838,972
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PRMT3
protein arginine methyltransferase 3
ISO
mRNA:increased expression:lung
RGD
PMID:20423833
RGD:9491823
NCBI chr21:42,406,327...42,530,157
Ensembl chr21:42,406,314...42,528,116
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PRMT5
protein arginine methyltransferase 5
ISO
mRNA:increased expression:lung, spleen
RGD
PMID:20423833
RGD:9491823
NCBI chr 8:3,248,349...3,257,567
Ensembl chr 8:3,248,404...3,257,456
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PROC
protein C, inactivator of coagulation factors Va and VIIIa
treatment
ISO
RGD
PMID:26381519
RGD:11099992
NCBI chr19:23,173,626...23,183,634
Ensembl chr19:23,173,635...23,183,563
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PTEN
phosphatase and tensin homolog
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17982072
NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176
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PTGDR
prostaglandin D2 receptor
susceptibility
ISO
OMIM
NCBI chr 8:28,480,446...28,491,331
Ensembl chr 8:28,480,478...28,488,855
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PTGDR2
prostaglandin D2 receptor 2
ISO
Aspirin exacerbated asthma CTD Direct Evidence: therapeutic
RGD CTD
PMID:18757520 PMID:19392992 PMID:19796209 PMID:27103662
RGD:5135018 RGD:5135019 RGD:5135020
NCBI chr18:55,426,632...55,431,916
Ensembl chr18:55,429,308...55,430,510
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PTGER3
prostaglandin E receptor 3
treatment
ISO
RGD
PMID:23221044
RGD:10043366
NCBI chr 6:74,932,789...74,986,573
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PTGS2
prostaglandin-endoperoxide synthase 2
susceptibility severity
ISO
DNA:SNP: :8473T>C (human) mRNA:increased expression:lung mRNA, protein:increased expression:lung: DNA:SNP: :rs689465 (human)
RGD
PMID:15316498 PMID:17573729 PMID:18097056 PMID:18489027 PMID:19342146 PMID:19862936 PMID:19878559 More...
RGD:5135514 RGD:5135515 RGD:5135522 RGD:5135526 RGD:5135534 RGD:5143923 RGD:5143931
NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
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RAD50
RAD50 double strand break repair protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24241537
NCBI chr11:20,836,863...20,928,930
Ensembl chr11:20,836,879...20,928,819
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RHOA
ras homolog family member A
ISO
RGD
PMID:18391481
RGD:2298885
NCBI chr20:39,824,552...39,888,089
Ensembl chr20:39,824,575...39,887,215
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RUNX3
RUNX family transcription factor 3
ISO
OMIM:600807
MouseDO
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SCGB1A1
secretoglobin family 1A member 1
susceptibility
ISO
associated with allergic rhinitis; DNA:SNP:exon:38G>A (human) ClinVar Annotator: match by term: Asthma, susceptibility to
RGD ClinVar
PMID:9550363 PMID:9643286 PMID:12100044 PMID:21255142
RGD:5144226
NCBI chr18:54,187,487...54,191,493
Ensembl chr18:54,187,487...54,191,482
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SCGB3A2
secretoglobin family 3A member 2
susceptibility severity no_association
ISO
ClinVar Annotator: match by term: Asthma, susceptibility to DNA:SNP:promoter:-112G>A (human)
OMIM ClinVar RGD
PMID:11813133 PMID:18089940 PMID:18201431
RGD:5144230 RGD:5144231
NCBI chr 2:42,147,596...42,151,224
Ensembl chr 2:42,147,596...42,151,191
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SELL
selectin L
ISO
RGD
PMID:21437035 PMID:21515793
RGD:5685685 RGD:5685696
NCBI chr 7:28,906,752...28,927,959
Ensembl chr 7:28,906,809...29,094,008
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SERPINA1
serpin family A member 1
ISO
Fisher rats, shown to exhibit hyperactive airway responses at 14 days of age, had higher transcript and protein levels of Serpina1 than same age Brown Norway rats.
RGD
PMID:20118217
RGD:5131869
NCBI chr 8:63,388,498...63,400,377
Ensembl chr 8:63,376,945...63,398,435
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SERPINE1
serpin family E member 1
severity no_association susceptibility
ISO
protein:increased activity, increased expression:plasma, lung protein:increased expression:plasma DNA:polymorphism:promoter:rs1799768 (human)
RGD
PMID:18594148 PMID:19063817 PMID:19604112 PMID:19703828
RGD:4144831 RGD:4144832 RGD:4144833 RGD:4144836
NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301
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SFTPB
surfactant protein B
ISO
protein:increased expression:lung protein:decreased expression:lung, Clara cell mRNA, protein:decreased expression:lung
RGD
PMID:11472974 PMID:15816355 PMID:16629790 PMID:18926058
RGD:4143289 RGD:4143398 RGD:4143462 RGD:4143465
NCBI chr17:39,419,305...39,428,513
Ensembl chr17:39,386,584...39,426,229
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SFTPC
surfactant protein C
susceptibility
ISO
mRNA, protein:decreased expression:lung protein:increased expression:lung DNA:polymorphism: :p.A53T (human)
RGD
PMID:11472974 PMID:16629790 PMID:19910179
RGD:4143462 RGD:4143465 RGD:4144063
NCBI chr25:35,088,295...35,090,995
Ensembl chr25:35,088,279...35,091,457
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SFTPD
surfactant protein D
ISO
mRNA, protein:increased expression:lung associated with Bronchitis;protein:increased expression:lung
RGD
PMID:11472974 PMID:16629790 PMID:16839409 PMID:18266831 PMID:18802356
RGD:4143462 RGD:4143465 RGD:4143508 RGD:4143516 RGD:4143517
NCBI chr 4:29,394,755...29,407,499
Ensembl chr 4:29,394,678...29,407,293
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SLC11A1
solute carrier family 11 member 1
ISO
RGD
PMID:12847242
RGD:5684966
NCBI chr37:25,039,203...25,047,461
Ensembl chr37:25,038,360...25,047,282
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SLC18A3
solute carrier family 18 member A3
ISO
RGD
PMID:17328924
RGD:5686690
NCBI chr28:1,476,873...1,478,538
Ensembl chr28:1,476,774...1,478,505
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SLC22A1
solute carrier family 22 member 1
ISO
RGD
PMID:17328924
RGD:5686690
NCBI chr 1:49,268,978...49,296,522
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SLC5A7
solute carrier family 5 member 7
ISO
mRNA:decreased expression:lung
RGD
PMID:17328924
RGD:5686690
NCBI chr10:35,879,880...35,908,203
Ensembl chr10:35,883,245...35,908,569
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SLC6A4
solute carrier family 6 member 4
susceptibility
ISO
DNA:repeat:intron (human)
RGD
PMID:19806585
RGD:4889460
NCBI chr 9:44,224,026...44,259,655
Ensembl chr 9:44,224,229...44,259,736
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SOD1
superoxide dismutase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22867017
NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815
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SOD2
superoxide dismutase 2
ISO
RGD
PMID:15743779
RGD:1581231
NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
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STAT4
signal transducer and activator of transcription 4
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:18211752 PMID:28807506
RGD:2317290
NCBI chr37:1,566,563...1,685,378
Ensembl chr37:1,566,585...1,829,894
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STAT6
signal transducer and activator of transcription 6
treatment
ISO
RGD
PMID:16083555 PMID:19087723
RGD:7244151 RGD:7244153
NCBI chr10:1,232,515...1,247,011
Ensembl chr10:1,233,691...1,247,075
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TAC1
tachykinin precursor 1
ISO
protein:increased expression:lung
RGD
PMID:11031342
RGD:5147836
NCBI chr14:22,631,106...22,640,283
Ensembl chr14:22,632,642...22,640,258
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TACR1
tachykinin receptor 1
ISO
mRNA,protein:increased expression:lung mRNA:increased expression:lung
RGD
PMID:8240667 PMID:16409782 PMID:17392578
RGD:2304339 RGD:5147475 RGD:5147645
NCBI chr17:48,038,010...48,178,971
Ensembl chr17:48,038,010...48,178,971
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TACR2
tachykinin receptor 2
ISO
DNA:SNP:cds:p.G231E (human)
RGD
PMID:19880429 PMID:20175803
RGD:5147640 RGD:5147641
NCBI chr 4:20,518,797...20,531,118
Ensembl chr 4:20,517,563...20,531,867
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TAP1
transporter 1, ATP binding cassette subfamily B member
susceptibility
ISO
DNA:polymorphism: :
RGD
PMID:12640628
RGD:5147845
NCBI chr12:2,424,049...2,432,165
Ensembl chr12:2,378,126...2,432,303
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TBX21
T-box transcription factor 21
ISO
CTD Direct Evidence: marker/mechanism OMIM:600807
CTD MouseDO
PMID:15806396
NCBI chr 9:24,077,752...24,086,560
Ensembl chr 9:24,077,761...24,086,261
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TBXA2R
thromboxane A2 receptor
severity susceptibility
ISO
DNA:polymorphism:cds:924T>C(human) ClinVar Annotator: match by term: Asthma
RGD ClinVar
PMID:2955539 PMID:7929844 PMID:8428006 PMID:8613548 PMID:12000493 PMID:15805995 More...
RGD:11059534 RGD:11059535
NCBI chr20:55,819,866...55,829,395
Ensembl chr20:55,824,410...55,828,980
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THBD
thrombomodulin
ISO
RGD
PMID:20709825
RGD:5684984
NCBI chr24:599,773...601,649
Ensembl chr24:599,773...601,649
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TIMP3
TIMP metallopeptidase inhibitor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16926187
NCBI chr10:30,627,154...30,681,520
Ensembl chr10:30,627,154...30,694,288
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TLR1
toll like receptor 1
susceptibility
ISO
DNA:SNP (human)
RGD
PMID:18547625
RGD:4889528
NCBI chr 3:73,504,359...73,544,822
Ensembl chr 3:73,539,715...73,544,624
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TLR10
toll like receptor 10
susceptibility
ISO
DNA:SNP (human)
RGD
PMID:18547625
RGD:4889528
NCBI chr 3:73,561,596...73,589,286
Ensembl chr 3:73,568,321...73,570,744
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TLR2
toll like receptor 2
susceptibility severity
ISO
DNA:SNP: :rs4696480 (human) DNA:SNP: :rs7656411 (human) DNA:SNP: :rs3804100 (human) DNA:polymorphism:cds:p.R753Q(human) DNA:SNP: :596T>C (human)
RGD
PMID:18202345 PMID:18787777 PMID:19096003 PMID:19148143 PMID:20685742 PMID:20815312 PMID:22402138 More...
RGD:2312679 RGD:4144171 RGD:4144228 RGD:4145334 RGD:4145343 RGD:4145352 RGD:7800732
NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241
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TLR3
toll like receptor 3
no_association
ISO
Asthma, Virus-Induced; mRNA:increased expression:sputum (human) DNA:snp:cds:p.L412F (human)
RGD
PMID:14987294 PMID:17434873 PMID:17610940 PMID:21129050 PMID:21364926
RGD:5128500 RGD:5129226 RGD:5129475 RGD:5129478 RGD:5129493
NCBI chr16:44,617,012...44,633,591
Ensembl chr16:44,550,846...44,653,247
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TLR4
toll like receptor 4
susceptibility severity no_association
ISO
DNA:Polymorphism:cds:p.D299G (human) DNA:polymorphisms:cds:c.896A>G, 1196C>T (human) DNA:SNPs: :rs10983755, rs1927914 (human) protein:decreased expression:leukocytes, mononuclear DNA:SNPs::
RGD
PMID:15356557 PMID:16266379 PMID:19067129 PMID:19159017 PMID:19330007 PMID:20628601 PMID:20685742 More...
RGD:4144141 RGD:4144171 RGD:4144176 RGD:4144188 RGD:4144190 RGD:4144198 RGD:4144817
NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165
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TLR6
toll like receptor 6
susceptibility
ISO
DNA:SNP (human) DNA:SNP: :p.S249P (human)
RGD
PMID:15266299 PMID:18547625
RGD:4889528 RGD:4889538
NCBI chr 3:73,504,357...73,523,964
Ensembl chr 3:73,520,706...73,523,099
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TLR9
toll like receptor 9
susceptibility severity no_association
ISO
DNA:SNP:promoter:g.-1237T>C (rs5743836) (human) protein:increased expression:peripheral blood mononuclear cell (human) DNA:SNP:promoter:g.-1237T>C rs5743836 (human)
RGD
PMID:18312481 PMID:20016192 PMID:20072849 PMID:21324137
RGD:4144208 RGD:4889523 RGD:5129104 RGD:5130712
NCBI chr20:37,529,322...37,547,117
Ensembl chr20:37,542,340...37,547,114 Ensembl chr20:37,542,340...37,547,114
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TNC
tenascin C
ISO
protein:increased expression:bronchus basement membrane DNA:SNP:exon:p.L1677I (human) DNA:SNPs: :multiple (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:9310019 PMID:16115819 PMID:17125141 PMID:18305139
RGD:4889565 RGD:4889569 RGD:4889572 RGD:4889589
NCBI chr11:69,077,532...69,169,673
Ensembl chr11:69,077,535...69,170,281
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TNF
tumor necrosis factor
no_association susceptibility
ISO
DNA:polymorphism:promoter: ClinVar Annotator: match by term: Asthma, susceptibility to
RGD OMIM ClinVar
PMID:8056188 PMID:9818939 PMID:10450718 PMID:11261930 PMID:11506397 PMID:11826025 PMID:11896460 PMID:12485196 PMID:12530118 PMID:12746914 PMID:12759288 PMID:14681301 PMID:14718719 PMID:16418737 PMID:16720636 PMID:16865291 PMID:16909270 PMID:18050183 PMID:18713756 PMID:19365401 PMID:22760475 PMID:22992668 More...
RGD:4143254
NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
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TNFRSF1A
TNF receptor superfamily member 1A
ISO
protein:increased expression:lung (mouse)
RGD
PMID:20484920
RGD:5131201
NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282
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TNIP1
TNFAIP3 interacting protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24453940
NCBI chr 4:58,150,734...58,200,158
Ensembl chr 4:58,149,882...58,199,644
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TRPA1
transient receptor potential cation channel subfamily A member 1
severity
ISO
CTD Direct Evidence: marker/mechanism ovalbumin sensitization
CTD RGD
PMID:19458046 PMID:31969645
RGD:127285811
NCBI chr29:20,951,736...21,000,956
Ensembl chr29:20,951,716...21,001,208
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TSLP
thymic stromal lymphopoietin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21804549
NCBI chr 3:1,502,469...1,507,696
Ensembl chr 3:1,503,188...1,507,696
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UCN
urocortin
ISO
associated with Hypersensitivity;mRNA, protein:increased expression:lung
RGD
PMID:16427607
RGD:1642781
NCBI chr17:21,278,512...21,280,404
Ensembl chr17:21,278,932...21,279,312
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UTS2
urotensin 2
ISO
RGD
PMID:17045018
RGD:2306832
NCBI chr 5:61,503,268...61,508,146
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VDR
vitamin D receptor
no_association
ISO
DNA:SNP (human) DNA:SNPs (human) DNA:SNP: :rs7975232 (human) DNA:SNPs: :multiple (human)
RGD
PMID:15282200 PMID:19622139 PMID:20124605 PMID:21103062
RGD:4889854 RGD:4889866 RGD:4889867 RGD:4889868
NCBI chr27:6,852,915...6,909,466
Ensembl chr27:6,852,723...6,909,470
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VEGFA
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:sputum
CTD RGD
PMID:11907124 PMID:15201500 PMID:19178538 PMID:19263519
RGD:6892723
NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965
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VIP
vasoactive intestinal peptide
ISO
RGD
PMID:16782752 PMID:21419198
RGD:5685381 RGD:5685620
NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700
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WDR36
WD repeat domain 36
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19198610
NCBI chr 3:1,451,543...1,494,474
Ensembl chr 3:1,451,555...1,494,438
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CXCL8
C-X-C motif chemokine ligand 8
treatment
ISO
RGD
PMID:30059697
RGD:39939057
NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354
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CCL26
C-C motif chemokine ligand 26
treatment
ISO
RGD
PMID:25530546
RGD:11081163
NCBI chr 6:7,151,352...7,154,509
Ensembl chr 6:7,151,212...7,154,726
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CYSLTR1
cysteinyl leukotriene receptor 1
treatment
ISO
RGD
PMID:23933317
RGD:40903070
NCBI chr X:60,462,290...60,513,155
Ensembl chr X:60,463,526...60,464,548
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DLA-DRB1
MHC class II DLA DRB1 beta chain
susceptibility
ISO
RGD
PMID:22397267
RGD:13506905
NCBI chr12:2,151,409...2,164,564
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DLA88
MHC class I DLA-88
susceptibility
ISO
DNA:polymorphism:
RGD
PMID:28380482
RGD:13506910
NCBI chr12:892,442...895,691
Ensembl chr12:892,388...1,021,690
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EPX
eosinophil peroxidase
ISO
protein:increased expression:urine:
RGD
PMID:11846868
RGD:13506893
NCBI chr 9:32,855,568...32,865,445
Ensembl chr 9:32,855,507...32,865,022
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IL25
interleukin 25
treatment
ISO
RGD
PMID:17889290
RGD:40902975
NCBI chr 8:3,621,268...3,624,689
Ensembl chr 8:3,618,161...3,624,043
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TREM1
triggering receptor expressed on myeloid cells 1
exacerbates
ISO
RGD
PMID:21592044
RGD:126928124
NCBI chr12:9,990,678...10,000,195
Ensembl chr12:9,990,679...10,000,236
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CACNG6
calcium voltage-gated channel auxiliary subunit gamma 6
susceptibility
ISO
DNA:SNP,haplotype:rs192808(human)
RGD
PMID:20860846
RGD:13524562
NCBI chr 1:103,227,936...103,244,263
Ensembl chr 1:103,226,597...103,244,441
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CCR3
C-C motif chemokine receptor 3
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:20022477 PMID:20485159
RGD:4145619
NCBI chr20:42,382,380...42,398,449
Ensembl chr20:42,383,135...42,384,217
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CYSLTR1
cysteinyl leukotriene receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16502481 PMID:17641958 PMID:20485159
NCBI chr X:60,462,290...60,513,155
Ensembl chr X:60,463,526...60,464,548
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CYSLTR2
cysteinyl leukotriene receptor 2
ISO
DNA:SNPs: :-819T>G, 2078C>T, 2534A>G (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15970796 PMID:16502481 PMID:20485159
RGD:5144000
NCBI chr22:2,914,960...2,962,517
Ensembl chr22:2,917,514...2,918,551
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DLA-DQB1
major histocompatibility complex, class II, DQ beta 1
susceptibility
ISO
RGD
PMID:25975240
RGD:11074090
NCBI chr12:2,305,307...2,307,711
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DLA-DRB1
MHC class II DLA DRB1 beta chain
susceptibility
ISO
RGD
PMID:25975240
RGD:11074090
NCBI chr12:2,151,409...2,164,564
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FANCC
FA complementation group C
ISO
DNA:haplotype::rs4647416(human)
RGD
PMID:21670957
RGD:11045795
NCBI chr 1:71,388,931...71,678,019
Ensembl chr 1:71,487,601...71,678,506
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IL4
interleukin 4
susceptibility
ISO
DNA:SNPs:promoter,5'UTR,intron:multiple
RGD
PMID:20921925
RGD:11528633
NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534
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LTC4S
leukotriene C4 synthase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9393345 PMID:9466979 PMID:10970818 PMID:20485159
NCBI chr11:1,893,927...1,897,028
Ensembl chr11:1,894,380...1,897,752
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MS4A2
membrane spanning 4-domains A2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16502481
NCBI chr21:50,439,133...50,456,785
Ensembl chr21:50,450,024...50,456,785
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POSTN
periostin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18391768
NCBI chr25:3,167,319...3,208,970
Ensembl chr25:3,167,359...3,208,411
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PTGDR2
prostaglandin D2 receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20485159
NCBI chr18:55,426,632...55,431,916
Ensembl chr18:55,429,308...55,430,510
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PTGER2
prostaglandin E receptor 2
ISO
ClinVar Annotator: match by term: Asthma, aspirin-induced, susceptibility to
ClinVar
PMID:15496426
NCBI chr 8:28,523,318...28,536,936
Ensembl chr 8:28,522,681...28,536,922
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PTGIR
prostaglandin I2 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20485159
NCBI chr 1:109,275,198...109,279,463
Ensembl chr 1:109,274,988...109,277,584
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PTGS2
prostaglandin-endoperoxide synthase 2
ISO
protein:increased expression:mast cell CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:9487340 PMID:16502481 PMID:20485159
RGD:5143936
NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
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TAP2
transporter 2, ATP binding cassette subfamily B member
ISO
RGD
PMID:21796142
RGD:5147839
NCBI chr12:2,407,512...2,417,469
Ensembl chr12:2,378,126...2,432,303
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TBX21
T-box transcription factor 21
ISO
ClinVar Annotator: match by term: Asthma, aspirin-induced, susceptibility to
ClinVar
PMID:15806396
NCBI chr 9:24,077,752...24,086,560
Ensembl chr 9:24,077,761...24,086,261
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TBXA2R
thromboxane A2 receptor
susceptibility
ISO
DNA:polymorphism: :795T>C (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15898979 PMID:16502481 PMID:20485159
RGD:11059537
NCBI chr20:55,819,866...55,829,395
Ensembl chr20:55,824,410...55,828,980
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DLA-DRA
MHC class II DR alpha chain
susceptibility
ISO
DNA:SNPs,haplotype:introns:
RGD
PMID:22391069
RGD:13506908
NCBI chr12:2,133,026...2,137,825
Ensembl chr12:2,132,499...2,168,975
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TBX21
T-box transcription factor 21
ISO
ClinVar Annotator: match by term: Asthma and nasal polyps
ClinVar
PMID:15806396
NCBI chr 9:24,077,752...24,086,560
Ensembl chr 9:24,077,761...24,086,261
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ALOX15
arachidonate 15-lipoxygenase
ISO
ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance
ClinVar
PMID:17959182 PMID:21558275 PMID:25741868 PMID:30643255
NCBI chr 5:31,883,544...31,891,357
Ensembl chr 5:31,882,501...32,038,119
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LTC4S
leukotriene C4 synthase
ISO
ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance
ClinVar
PMID:25741868
NCBI chr11:1,893,927...1,897,028
Ensembl chr11:1,894,380...1,897,752
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PTGER2
prostaglandin E receptor 2
susceptibility
ISO
CTD Direct Evidence: marker/mechanism
OMIM CTD
NCBI chr 8:28,523,318...28,536,936
Ensembl chr 8:28,522,681...28,536,922
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TBX21
T-box transcription factor 21
ISO
ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance
ClinVar OMIM
PMID:25741868
NCBI chr 9:24,077,752...24,086,560
Ensembl chr 9:24,077,761...24,086,261
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NFKBIA
NFKB inhibitor alpha
exacerbates
ISO
associated with respiratory syncytial virus infectious disease;DNA:SNPs:protomer: (rs2233409) (human)
RGD
PMID:23487427
RGD:40902982
NCBI chr 8:14,100,203...14,103,453
Ensembl chr 8:14,100,671...14,103,433
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NGF
nerve growth factor
treatment
ISO
RGD
PMID:30681402
RGD:405100716
NCBI chr17:52,900,647...52,901,607
Ensembl chr17:52,900,647...52,901,607
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CCL26
C-C motif chemokine ligand 26
severity
ISO
protein:increased expression:sputum (human)
RGD
PMID:25936567
RGD:11531115
NCBI chr 6:7,151,352...7,154,509
Ensembl chr 6:7,151,212...7,154,726
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EPX
eosinophil peroxidase
treatment
ISO
RGD
PMID:28751233
RGD:13506890
NCBI chr 9:32,855,568...32,865,445
Ensembl chr 9:32,855,507...32,865,022
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ALOX5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:10984370
RGD:4890423
NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609
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CCL5
C-C motif chemokine ligand 5
ISO
protein:increased secretion:lung, secretion (human)
RGD
PMID:19996575
RGD:4892021
NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852
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TACR1
tachykinin receptor 1
ISO
RGD
PMID:8630576
RGD:5147837
NCBI chr17:48,038,010...48,178,971
Ensembl chr17:48,038,010...48,178,971
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ACSL3
acyl-CoA synthetase long chain family member 3
ISO
RGD
PMID:23526225
RGD:13831300
NCBI chr37:28,882,264...28,929,451
Ensembl chr37:28,864,147...28,938,866
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BCL2
BCL2 apoptosis regulator
treatment
ISO
RGD
PMID:29713367
RGD:13792581
NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
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CD86
CD86 molecule
treatment
ISO
RGD
PMID:25344652
RGD:11354965
NCBI chr33:25,256,267...25,318,855
Ensembl chr33:25,256,267...25,318,087
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FAS
Fas cell surface death receptor
treatment
ISO
RGD
PMID:29713367
RGD:13792581
NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321
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FASLG
Fas ligand
treatment
ISO
RGD
PMID:29713367
RGD:13792581
NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224
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IL23A
interleukin 23 subunit alpha
ISO
RGD
PMID:19935773 PMID:26344076
RGD:11251537 RGD:5037240
NCBI chr10:635,384...640,715
Ensembl chr10:638,719...640,359
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AGER
advanced glycosylation end-product specific receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33075463
NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129
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B9D2
B9 domain containing 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25721048
NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885
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CDH17
cadherin 17
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25918132
NCBI chr29:38,918,098...38,980,709
Ensembl chr29:38,918,574...38,977,217
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DLA-12
MHC class I DLA-12
susceptibility
ISO
DNA:SNP: :rs1573294(human)
RGD
PMID:24709764
RGD:13506912
NCBI chr12:933,321...936,671
Ensembl chr12:932,613...987,561
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DLA-DOA
HLA class II histocompatibility antigen, DO alpha chain-like
treatment
ISO
DNA:SNP: :rs3128935(human)
RGD
PMID:24709764
RGD:13506912
NCBI chr12:2,563,673...2,568,328
Ensembl chr12:2,563,673...2,568,328
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DLA88
MHC class I DLA-88
susceptibility
ISO
DNA:SNP: :rs1811197(human)
RGD
PMID:24709764
RGD:13506912
NCBI chr12:892,442...895,691
Ensembl chr12:892,388...1,021,690
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HERC2
HECT and RLD domain containing E3 ubiquitin protein ligase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25918132
NCBI chr 3:31,723,113...31,966,061
Ensembl chr 3:31,723,500...31,966,199
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PLA2G4A
phospholipase A2 group IVA
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27504716
NCBI chr 7:19,804,412...19,955,215
Ensembl chr 7:19,832,664...19,966,936
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PRKCA
protein kinase C alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27504716
NCBI chr 9:13,638,106...13,879,571
Ensembl chr 9:13,644,010...13,967,630
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PRKD1
protein kinase D1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27504716
NCBI chr 8:9,004,641...9,327,054
Ensembl chr 8:9,005,115...9,328,358
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PTGS1
prostaglandin-endoperoxide synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25721048
NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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PTGS2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25721048
NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
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TENM3
teneurin transmembrane protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25918132
NCBI chr16:47,440,673...47,883,311
Ensembl chr16:47,441,348...48,044,322 Ensembl chr16:47,441,348...48,044,322
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TNF
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25721048
NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
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PLA2G7
phospholipase A2 group VII
ISO
ClinVar Annotator: match by term: PLA2G7-related condition | ClinVar Annotator: match by term: Platelet-activating factor acetylhydrolase deficiency
OMIM ClinVar
PMID:8675689 PMID:9412624 PMID:10194471 PMID:10733466 PMID:15115767 PMID:16787988 PMID:25741868 PMID:28406212 More...
NCBI chr12:14,866,229...14,908,230
Ensembl chr12:14,866,229...14,908,114
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IFNG
interferon gamma
resistance
ISO
RGD
PMID:20817868
RGD:4145651
NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698
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IL1B
interleukin 1 beta
ISO
protein:increased expression:lung
RGD
PMID:9927362
RGD:4143184
NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458
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IL5
interleukin 5
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:10934091
RGD:4890960
NCBI chr11:20,825,469...20,827,269
Ensembl chr11:20,825,469...20,827,269
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MPO
myeloperoxidase
ISO
protein:increased expression:serum
RGD
PMID:10731862
RGD:5130994
NCBI chr 9:32,927,483...32,938,007
Ensembl chr 9:32,927,483...32,937,820
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