RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: nose disease
Accession: DOID:2825
browse the term
Definition: Disorders of the nose, general or unspecified.
Synonyms: exact_synonym: Nasal Diseases; Nasal Disorder; disorder of the nose; nasal disease; nasal disorders; nose diseases
primary_id: MESH:D009668
xref: MONDO:0002436
For additional species annotation, visit the
Alliance of Genome Resources .
G
Abcb1a
ATP binding cassette subfamily B member 1A
severity
ISO
DNA:snp:exon:c.1236C>T (human)
RGD
PMID:24040855
RGD:8657076
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Ace
angiotensin I converting enzyme
no_association
ISO
DNA:deletion:intron:IVS16+1464-1751del (human)
RGD
PMID:15112973
RGD:8142345
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
G
Bcl2
BCL2, apoptosis regulator
IEP
mRNA, protein:increased expression:nasal mucosa (rat)
RGD
PMID:15362690
RGD:11522724
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Cat
catalase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29028686
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccl11
C-C motif chemokine ligand 11
treatment
IDA
RGD
PMID:23089405
RGD:7248414
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
G
Ccl26
C-C motif chemokine ligand 26
ISO
protein:increased expression:oronasal secretion (human)
RGD
PMID:23883806
RGD:7364793
NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335
G
Cd40
CD40 molecule
ISO
protein:increased expression:lymphocyte
RGD
PMID:19086656
RGD:8547782
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
G
Cd40lg
CD40 ligand
ISO
protein:increased expression:lymphocyte
RGD
PMID:19086656
RGD:8547782
NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
G
Cldn3
claudin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33441633
NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
G
Cldn7
claudin 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33441633
NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171
G
Ctla4
cytotoxic T-lymphocyte-associated protein 4
treatment
ISO
RGD
PMID:10436391
RGD:11344920
NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
G
F2
coagulation factor II, thrombin
ISO
protein:increased expression:nasal mucus
RGD
PMID:21711961
RGD:5147783
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
G
Fcgr3a
Fc gamma receptor 3A
susceptibility
ISO
DNA:polymorphism:exon:p.F158V(rs396991)(human)
RGD
PMID:18199088
RGD:5508449
NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921
G
Gria1
glutamate ionotropic receptor AMPA type subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34624383
NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
G
Gria2
glutamate ionotropic receptor AMPA type subunit 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34624383
NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
G
Hmox1
heme oxygenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:36127783
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hrh1
histamine receptor H 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23333628
NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
G
Ifng
interferon gamma
treatment
ISO IDA
associated with Asthma CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:29871060 PMID:12787306 PMID:18510219
RGD:7829803 , RGD:10755770
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Il10
interleukin 10
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:36127783 PMID:23883806 PMID:23253209
RGD:7364793 , RGD:7364818
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il13
interleukin 13
susceptibility no_association
ISO
DNA:polymorphism:exon:c. 2044G>A (human) CTD Direct Evidence: marker/mechanism DNA:missense mutation:cds:p.R130Q (rs20541) (human) DNA:SNPs:promoter, cds:-1112C>T, p.R130Q (rs1800925, rs20541) (human) DNA:SNP:promoter:-1512A>C (rs1881457) (human)
CTD OMIM RGD
PMID:17091279 PMID:22852128 PMID:12928861 PMID:23996716
RGD:4152796 , RGD:8549518 , RGD:8549516 , RGD:8549501
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
G
Il13ra2
interleukin 13 receptor subunit alpha 2
ISO
protein:increased expression:serum
RGD
PMID:21462799
RGD:8549521
NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381
G
Il17a
interleukin 17A
susceptibility
ISO
DNA:snp:promoter:c.-444A>G (human) mRNA:increased expression:peripheral blood mononuclear cell (human)
RGD
PMID:22507625 PMID:21535180
RGD:9068429 , RGD:5147409
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
G
Il18
interleukin 18
severity no_association
ISO
DNA:SNP:promoter:-137G>C (rs187238) (human) DNA:SNP:promoter:-140C>G (rs360721) (human)
RGD
PMID:22840759 PMID:22840759
RGD:8655914 , RGD:8655914
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il1b
interleukin 1 beta
ISO
protein:increased expression:nasal mucus
RGD
PMID:7750009
RGD:7401199
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il2
interleukin 2
IEP
RGD
PMID:12592663
RGD:8662963
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Il4
interleukin 4
treatment
ISO IEP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:36127783 PMID:9893928 PMID:24620662 PMID:8908280 PMID:14653048
RGD:7829796 , RGD:11522769 , RGD:7829827 , RGD:7829802
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Il5
interleukin 5
treatment
IEP
RGD
PMID:23934070 PMID:24620662
RGD:11354976 , RGD:11522769
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
G
Itgb2
integrin subunit beta 2
treatment
IEP
RGD
PMID:12046991
RGD:9698435
NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
G
Mrc1
mannose receptor, C type 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:36127783
NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
G
Muc1
mucin 1, cell surface associated
severity
ISO IMP IEP
mRNA,protein:decreased expression:nasal mucosa
RGD
PMID:31425778 PMID:31425778 PMID:31425778
RGD:127345100 , RGD:127345100 , RGD:127345100
NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
G
Muc1em1Cgen
mucin 1, cell surface associated; TALEN induced mutant 1, Cgen
severity
IMP
RGD
PMID:31425778
RGD:127345100
G
Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
IEP
mRNA, protein:increased expression:nasal cavity epithelium
RGD
PMID:22972875
RGD:7364746
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
G
Nod2
nucleotide-binding oligomerization domain containing 2
ISO
mRNA:increased expression:nasal mucosa (human)
RGD
PMID:23858718
RGD:8547523
NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
G
Ocln
occludin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33441633
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
G
Pon1
paraoxonase 1
severity
ISO
protein:decreased activity:plasma (human)
RGD
PMID:23406590
RGD:8547583
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
G
Prkg1
protein kinase cGMP-dependent 1
IEP
protein:increased expression:nasal cavity epithelium
RGD
PMID:24012634
RGD:7775060
NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
G
Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16979129
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
RT1-M3-1
RT1 class Ib, locus M3, gene 1
ISO
RGD
PMID:20487636
RGD:5144132
NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
G
Scgb1a1
secretoglobin family 1A member 1
ISO
mRNA:decreased expression:nasal mucosa, lung
RGD
PMID:17882576
RGD:5144135
NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610
G
Scgb3a2
secretoglobin, family 3A, member 2
susceptibility
ISO
DNA:SNP: :rs7726552 (human)
RGD
PMID:21410962
RGD:5144225
NCBI chr18:35,932,840...35,935,762
Ensembl chr18:35,932,840...35,935,762
G
Serpine1
serpin family E member 1
ISO
mRNA:increased expression:nasal mucosa (mouse)
RGD
PMID:21339035
RGD:8547809
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
G
Tacr1
tachykinin receptor 1
IEP
mRNA:increased expression:nasal mucosa
RGD
PMID:12768696
RGD:5147835
NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
G
Tgfb1
transforming growth factor, beta 1
treatment
IEP
RGD
PMID:31368266
RGD:14995445
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Tlr2
toll-like receptor 2
severity
ISO
DNA:polymorphism:cds:p.R753Q(human) protein:increased expression:neutrophil: mRNA:decreased expression:nasal mucosa:
RGD
PMID:22402138 PMID:22555057 PMID:18381801 PMID:18219831
RGD:7800732 , RGD:8552993 , RGD:8552972 , RGD:7800742
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
G
Tlr4
toll-like receptor 4
severity treatment susceptibility no_association
ISO
DNA:polymorphism:cds:p.D299G(human) protein:increased expression:nasal lavage,leukocyte, bone marrow: protein:decreased expression:nasal mucosa: DNA:SNP: :rs1927911(human) DNA:polymorphism: :4216G>C(human)
RGD
PMID:22402138 PMID:22555057 PMID:22577387 PMID:17069098 PMID:23639307 PMID:19763595 More...
RGD:7800732 , RGD:8552993 , RGD:7800740 , RGD:7800738 , RGD:7800736 , RGD:4145354
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Tlr9
toll-like receptor 9
ISO
protein:decreased expression:nasal mucosa:
RGD
PMID:22577387
RGD:7800740
NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
treatment
ISO
associated with Eosinophilic Esophagitis; DNA:polymorphisms::
RGD
PMID:26416193
RGD:11352743
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Il3
interleukin 3
susceptibility
ISO
DNA:SNP: :rs40401(human)
RGD
PMID:23953855
RGD:13506915
NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
G
Smchd1
structural maintenance of chromosomes flexible hinge domain containing 1
ISO
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Arhinia, choanal atresia, and microphthalmia
CTD ClinVar OMIM
PMID:672092 PMID:5032329 PMID:6802865 PMID:8446727 PMID:8723126 PMID:11321738 PMID:16353241 PMID:23143600 PMID:23432817 PMID:23852095 PMID:25741868 PMID:26440771 PMID:26467025 PMID:26842768 PMID:28067909 PMID:28067911 PMID:28492532 PMID:31243061 PMID:31312724 More...
NCBI chr 9:111,243,445...111,387,272
Ensembl chr 9:111,247,702...111,349,665
G
RT1-Da
RT1 class II, locus Da
susceptibility
ISO
DNA:SNPs,haplotype:introns:
RGD
PMID:22391069
RGD:13506908
NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
G
Tbx21
T-box transcription factor 21
ISO
ClinVar Annotator: match by term: Asthma and nasal polyps
ClinVar
PMID:15806396
NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
G
Alox15
arachidonate 15-lipoxygenase
ISO
ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance
ClinVar
PMID:17959182 PMID:21558275 PMID:25741868 PMID:30643255
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
G
Ltc4s
leukotriene C4 synthase
ISO
ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance
ClinVar
PMID:25741868
NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
G
Ptger2
prostaglandin E receptor 2
susceptibility
ISO
CTD Direct Evidence: marker/mechanism
OMIM CTD
NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
G
Tbx21
T-box transcription factor 21
ISO
ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance CTD Direct Evidence: marker/mechanism
ClinVar OMIM CTD
PMID:25741868
NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
G
Frem1
Fras1 related extracellular matrix 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23221805
NCBI chr 5:97,321,266...97,469,523
Ensembl chr 5:97,322,538...97,469,543
G
Kmt2d
lysine methyltransferase 2D
ISO
ClinVar Annotator: match by term: Branchial arch abnormalities, choanal atresia, athelia, hearing loss, and hypothyroidism syndrome | ClinVar Annotator: match by term: Choanal atresia-athelia-hypothyroidism-delayed puberty-short stature syndrome
OMIM ClinVar
PMID:12002153 PMID:24728327 PMID:25590979 PMID:25741868 PMID:28492532 PMID:31949313 PMID:32083401 More...
NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325
G
Wfdc2
WAP four-disulfide core domain 2
ISO
OMIM
NCBI chr 3:153,286,946...153,314,832
Ensembl chr 3:153,286,131...153,292,807
G
Adnp2
ADNP homeobox 2
ISO
ClinVar Annotator: match by term: Burn-McKeown syndrome
ClinVar
PMID:25434003
NCBI chr18:73,571,870...73,597,088
Ensembl chr18:73,571,936...73,628,484
G
Atp9b
ATPase phospholipid transporting 9B (putative)
ISO
ClinVar Annotator: match by term: Burn-McKeown syndrome
ClinVar
PMID:25434003
NCBI chr18:74,176,863...74,368,993
Ensembl chr18:74,176,863...74,368,953
G
Ctdp1
CTD phosphatase subunit 1
ISO
ClinVar Annotator: match by term: Burn-McKeown syndrome
ClinVar
PMID:25434003
NCBI chr18:73,854,277...73,916,232
Ensembl chr18:73,854,282...73,916,457
G
Galr1
galanin receptor 1
ISO
ClinVar Annotator: match by term: Burn-McKeown syndrome
ClinVar
PMID:25434003
NCBI chr18:75,772,021...75,787,577
Ensembl chr18:75,772,023...75,787,577
G
Hsbp1l1
heat shock factor binding protein 1-like 1
ISO
ClinVar Annotator: match by term: Burn-McKeown syndrome
ClinVar
PMID:25434003
NCBI chr18:73,682,286...73,690,061
Ensembl chr18:73,682,286...73,688,045
G
Kcng2
potassium voltage-gated channel modifier subfamily G member 2
ISO
ClinVar Annotator: match by term: Burn-McKeown syndrome
ClinVar
PMID:25434003
NCBI chr18:73,742,224...73,810,420
Ensembl chr18:73,743,074...73,808,723
G
Mbp
myelin basic protein
ISO
ClinVar Annotator: match by term: Burn-McKeown syndrome
ClinVar
PMID:25434003
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
G
Nfatc1
nuclear factor of activated T-cells 1
ISO
ClinVar Annotator: match by term: Burn-McKeown syndrome
ClinVar
PMID:25434003
NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
G
Pard6g
par-6 family cell polarity regulator gamma
ISO
ClinVar Annotator: match by term: Burn-McKeown syndrome
ClinVar
PMID:25434003
NCBI chr18:73,497,992...73,565,048
Ensembl chr18:73,498,021...73,565,029
G
Rbfa
ribosome binding factor A
ISO
ClinVar Annotator: match by term: Burn-McKeown syndrome
ClinVar
PMID:25434003
NCBI chr18:73,639,264...73,648,914
Ensembl chr18:73,639,260...73,648,915
G
Sall3
spalt-like transcription factor 3
ISO
ClinVar Annotator: match by term: Burn-McKeown syndrome
ClinVar
PMID:25434003
NCBI chr18:74,406,066...74,425,974
Ensembl chr18:74,407,560...74,426,789
G
Slc66a2
solute carrier family 66 member 2
ISO
ClinVar Annotator: match by term: Burn-McKeown syndrome
ClinVar
PMID:25434003
NCBI chr18:73,702,472...73,739,678
Ensembl chr18:73,702,564...73,739,676
G
Txnl4a
thioredoxin-like 4A
ISO
ClinVar Annotator: match by term: Bilateral choanal atresia, cardiac defects, deafness, and dysmorphic appearance | ClinVar Annotator: match by term: Burn-McKeown syndrome CTD Direct Evidence: marker/mechanism DNA:missense mutations,deletions:promoter, cds: DNA:deletions:promoter:
OMIM ClinVar CTD RGD
PMID:1342861 PMID:14564154 PMID:16523509 PMID:25434003 PMID:25741868 PMID:28492532 PMID:32735620 PMID:34713892 PMID:25434003 PMID:28905882 More...
RGD:11531484 , RGD:155882456
NCBI chr18:73,659,107...73,674,893
Ensembl chr18:73,659,107...73,674,893
G
Zfp236
zinc finger protein 236
ISO
ClinVar Annotator: match by term: Burn-McKeown syndrome
ClinVar
PMID:25434003
NCBI chr18:75,976,478...76,072,428
Ensembl chr18:75,978,231...76,073,737
G
Zfp516
zinc finger protein 516
ISO
ClinVar Annotator: match by term: Burn-McKeown syndrome
ClinVar
PMID:25434003
NCBI chr18:76,286,453...76,386,526
Ensembl chr18:76,302,096...76,385,269
G
Kmt2d
lysine methyltransferase 2D
ISO
ClinVar Annotator: match by term: Choanal atresia
ClinVar
PMID:25741868 PMID:31395954
NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325
G
Ptpn14
protein tyrosine phosphatase, non-receptor type 14
ISO
ClinVar Annotator: match by term: Choanal atresia and lymphedema
OMIM ClinVar
PMID:20826270 PMID:25741868
NCBI chr13:101,268,258...101,420,508
Ensembl chr13:101,268,416...101,414,088
G
Edn1
endothelin 1
ISO
protein:increased expression:inferior turbinate, nasal gland, inflammatory cell (human)
RGD
PMID:8845175
RGD:8661738
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
G
Cd8a
CD8 subunit alpha
ameliorates
ISO
protein:decreased expression:blood, T cell (human)
RGD
PMID:24639246
RGD:124715444
NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040
G
Il17a
interleukin 17A
ISO
protein:increased expression:uncinate process, nasal mucosa (human)
RGD
PMID:23613503
RGD:8696039
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
G
Il1rn
interleukin 1 receptor antagonist
susceptibility
ISO
DNA:repeats:intron:IVS2+914_1000dup I/II alleles (human)
RGD
PMID:16549749
RGD:8549791
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
G
Mbl2
mannose binding lectin 2
ISO
protein:decreased activity:serum:
RGD
PMID:23144819
RGD:8693716
NCBI chr 1:228,016,439...228,024,736
G
Prg2
proteoglycan 2, pro eosinophil major basic protein
disease_progression
ISO
associated with Nasal Polyps;
RGD
PMID:24450586
RGD:13506943
NCBI chr 3:70,062,535...70,066,102
Ensembl chr 3:70,062,535...70,066,101
G
Acvrl1
activin A receptor like type 1
ISO
ClinVar Annotator: match by term: Epistaxis
ClinVar
PMID:11484689 PMID:15687131 PMID:16540754 PMID:17786384 PMID:18159113 PMID:18498373 PMID:20056902 PMID:20501893 PMID:21378382 PMID:22632830 PMID:23124896 PMID:23298310 PMID:23919827 PMID:25741868 PMID:26387786 PMID:27316748 PMID:28492532 PMID:30260738 PMID:32581362 More...
NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591
G
Eng
endoglin
ISO
ClinVar Annotator: match by term: Spontaneous, recurrent epistaxis
ClinVar RGD
PMID:15879500 PMID:16542389 PMID:28492532 PMID:30251589 PMID:10562296
RGD:11041563
NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
G
Gstt1
glutathione S-transferase theta 1
susceptibility
ISO
DNA:deletion:cds (human)
RGD
PMID:18066575
RGD:7794809
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
G
Ccl7
C-C motif chemokine ligand 7
ISO
protein:increased expression:ethmoid sinus
RGD
PMID:9800627
RGD:6483785
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
ISO
RGD
PMID:15040115
RGD:8662355
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
G
Clu
clusterin
ISO
RGD
PMID:19903339
RGD:9014708
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
G
Sox2
SRY-box transcription factor 2
ISO
DNA:amplification
RGD
PMID:23544055
RGD:8661654
NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338
G
Tp53
tumor protein p53
ISO
RGD
PMID:19950227
RGD:8547762
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Npy
neuropeptide Y
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:9288221
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
G
Abcb1a
ATP binding cassette subfamily B member 1A
ISO
associated with Chronic Rhinosinusitis;protein:increased expression:nasal sinus (human)
RGD
PMID:22223515
RGD:8657074
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Adrb2
adrenoceptor beta 2
susceptibility
ISO
DNA:polymorphism:p.R16G(human)
RGD
PMID:17621827
RGD:8548469
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
G
Alox12
arachidonate 12-lipoxygenase, 12S type
ISO
mRNA:decreased expression:nasal cavity epithelium
RGD
PMID:20554417
RGD:5509597
NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
G
Alox15
arachidonate 15-lipoxygenase
ISO
mRNA:increased expression:nasal cavity epithelium CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:30643255 PMID:20554417
RGD:5509597
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
G
Ang
angiogenin
ISO
RGD
PMID:21711968
RGD:6892710
NCBI chr15:24,312,711...24,323,361
G
Anxa1
annexin A1
ISO
RGD
PMID:20549082
RGD:7421567
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
G
Bdnf
brain-derived neurotrophic factor
ISO
associated with Sinusitis;protein:decreased expression:respiratory system mucosa
RGD
PMID:19958603
RGD:4891064
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
G
Cat
catalase
ISO
protein:increased activity:nasal concha:
RGD
PMID:16287205
RGD:9479048
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccl1
C-C motif chemokine ligand 1
ISO
associated with Sinusitis
RGD
PMID:20598643
RGD:4891418
NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
G
Ccl11
C-C motif chemokine ligand 11
ISO
mRNA:increased expression:nasal cavity epithelium
RGD
PMID:10415058
RGD:4145448
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
G
Ccl2
C-C motif chemokine ligand 2
ISO
protein:increased expression:sinus:
RGD
PMID:22287435
RGD:7483612
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Ccl20
C-C motif chemokine ligand 20
ISO
associated with Allergic Rhinitis associated with Rhinosinusitis
RGD
PMID:19027509 PMID:22287435
RGD:7483586 , RGD:7483612
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
G
Ccl24
C-C motif chemokine ligand 24
ISO
mRNA:increased expression:nasal cavity epithelium
RGD
PMID:10415058
RGD:4145448
NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893
G
Ccl26
C-C motif chemokine ligand 26
ISO
associated with Sinusitis;mRNA:increased expression:nasal cavity epithelium
RGD
PMID:21303604
RGD:5130929
NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335
G
Ccr2
C-C motif chemokine receptor 2
ISO
RGD
PMID:22287435
RGD:7483612
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
G
Ccr6
C-C motif chemokine receptor 6
ISO
associated with Rhinosinusitis
RGD
PMID:22287435
RGD:7483612
NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603
G
Chia
chitinase, acidic
ISO
associated with Sinusitis; mRNA:increased expression:mucosa of ethmoidal sinus (human)
RGD
PMID:16871939
RGD:5024927
NCBI chr 2:193,614,374...193,656,532
Ensembl chr 2:193,614,114...193,656,533
G
Cxcl1
C-X-C motif chemokine ligand 1
ISO
associated with Sinusitis;mRNA:increased expression:respiratory system mucosa
RGD
PMID:19178793
RGD:5134986
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
G
Cxcl3
C-X-C motif chemokine ligand 3
ISO
associated with Sinusitis;mRNA:increased expression:respiratory system mucosa
RGD
PMID:19178793
RGD:5134986
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
G
Cysltr1
cysteinyl leukotriene receptor 1
ISO
protein:increased expression:nasal cavity epithelium associated with Asthma associated with Rhinitis;mRNA:increased expression:nasal cavity epithelium
RGD
PMID:16739673 PMID:11591188 PMID:16689996
RGD:4889117 , RGD:4848936 , RGD:4783198
NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121
G
Egr1
early growth response 1
ISO
mRNA:increased expression:nasal polyp (human)
RGD
PMID:19158123
RGD:4890001
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
G
Fas
Fas cell surface death receptor
ISO
protein:decreased expression:nasal polyp (human)
RGD
PMID:15283292
RGD:8662435
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Fgf1
fibroblast growth factor 1
ISO
RGD
PMID:16720444
RGD:8655569
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
G
Fgf2
fibroblast growth factor 2
ISO
RGD
PMID:16720444
RGD:8655569
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
G
Gstm1
glutathione S-transferase mu 1
ISO
associated with GSTT1 null genotype:DNA:deletion: :
RGD
PMID:16550944
RGD:4142528
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
G
Gstt1
glutathione S-transferase theta 1
ISO
DNA:deletion: :
RGD
PMID:19701760
RGD:4142518
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
G
Hgf
hepatocyte growth factor
ISO
mRNA,protein:increased expression:nasal cavity mucosa:
RGD
PMID:16982975
RGD:8548613
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
G
Icam1
intercellular adhesion molecule 1
ISO
protein:increased expression:nasal cavity epithelium
RGD
PMID:11593541
RGD:8547687
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Ifng
interferon gamma
ISO
protein:increased expression:nasal mucosa, tissue:
RGD
PMID:9149164
RGD:8158035
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Igf1
insulin-like growth factor 1
ISO
mRNA:increased expression:nasal cavity mucosa:
RGD
PMID:18202785
RGD:8548875
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Il10
interleukin 10
ISO
RGD
PMID:22462754
RGD:7364835
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il13
interleukin 13
ISO
associated with Rhinosinusitis;protein:increased expression:serum
RGD
PMID:23969075
RGD:8549540
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
G
Il16
interleukin 16
ISO
associated with Sinusitis
RGD
PMID:17431659
RGD:5024933
NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
G
Il17a
interleukin 17A
ISO
protein:increased expression:nose, serum associated with rhinitis; protein:increased expression:nasal mucosa
RGD
PMID:20506642 PMID:21091665
RGD:4889137 , RGD:4889132
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
G
Il1a
interleukin 1 alpha
susceptibility
ISO
associated with asthma;DNA:polymorphism:exon: DNA:SNPs:exon:
RGD
PMID:12752325 PMID:17638785
RGD:4142804 , RGD:4142855
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il5ra
interleukin 5 receptor subunit alpha
ISO
protein:increased expression:nasal mucus, serum
RGD
PMID:12752323
RGD:5128621
NCBI chr 4:139,630,652...139,664,593
Ensembl chr 4:139,632,066...139,668,544
G
Il9
interleukin 9
ISO
associated with Bronchial Hyperreactivity
RGD
PMID:15007348
RGD:5128694
NCBI chr17:8,111,772...8,114,895
Ensembl chr17:8,111,772...8,114,895
G
Itgal
integrin subunit alpha L
ISO
protein:increased expression:nasal cavity epithelium
RGD
PMID:11593541
RGD:8547687
NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
ISO
mRNA:decreased expression:nasal cavity epithelium
RGD
PMID:19158123
RGD:4890001
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
G
Kdr
kinase insert domain receptor
ISO
protein:increased expression:inferior nasal concha:
RGD
PMID:12515274
RGD:8551781
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
G
Kitlg
KIT ligand
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15813808
NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
G
Lepr
leptin receptor
ISO
mRNA:increased expression:nose
RGD
PMID:20422702
RGD:5129163
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
G
Mbl2
mannose binding lectin 2
ISO
associated with Sinusitis; protein:increased secretion:serum (human)
RGD
PMID:19593977
RGD:4889484
NCBI chr 1:228,016,439...228,024,736
G
Met
MET proto-oncogene, receptor tyrosine kinase
ISO
mRNA,protein:increased expression:nasal cavity mucosa:
RGD
PMID:16982975
RGD:8548613
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
G
Mmp1
matrix metallopeptidase 1
ISO
associated with Rhinosinusitis;mRNA:increased expression:nasal cavity mucosa
RGD
PMID:23064462
RGD:8549735
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
G
Mmp2
matrix metallopeptidase 2
treatment
ISO
associated with Rhinosinusitis;mRNA:increased expression:nasal cavity mucosa
RGD
PMID:23064462 PMID:21305560
RGD:8549735 , RGD:8656001
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
G
Mmp9
matrix metallopeptidase 9
susceptibility disease_progression
ISO
associated with Asthma, Aspirin-Induced; DNA:polymorphism:promoter: -1562C>T (human) associated with Rhinosinusitis;mRNA:increased expression:nasal cavity mucosa
RGD
PMID:19958602 PMID:23987197 PMID:23064462
RGD:5130861 , RGD:8657056 , RGD:8549735
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
ISO
RGD
PMID:15715404
RGD:7364740
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
G
Nos2
nitric oxide synthase 2
ISO
mRNA:increased expression:nasal mucosa DNA:repeats:promoter
RGD
PMID:20554417 PMID:18714530
RGD:5509597 , RGD:4891508
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nos3
nitric oxide synthase 3
ISO
protein:increased expression:nasal mucosa (human)
RGD
PMID:15942806
RGD:7771559
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
G
Plaur
plasminogen activator, urokinase receptor
ISO
associated with Sinusitis
RGD
PMID:21711960
RGD:6483796
NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
G
Pon1
paraoxonase 1
ISO
protein:decreased activity:serum (human)
RGD
PMID:23238704
RGD:8547666
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
G
Ppp1r9b
protein phosphatase 1, regulatory subunit 9B
ISO
associated with Chronic Rhinosinusitis;mRNA:increased expression:mucosa of paranasal sinus (human)
RGD
PMID:18391768
RGD:9999402
NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083
G
Ptgs1
prostaglandin-endoperoxide synthase 1
ISO
associated with Cystic Fibrosis; protein:increased expression:nasal mucosa:
RGD
PMID:16517580
RGD:5143924
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
G
Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
associated with Cystic Fibrosis; protein:increased expression:nasal mucosa:
RGD
PMID:16517580
RGD:5143924
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
RT1-Ba
RT1 class II, locus Ba
susceptibility
ISO
associated with intrinsic asthma;DNA:polymorphism:cds:HLA-DQA1*0201 (human) DNA:polymorphism,haplotype: :HLA-DQA1*0201
RGD
PMID:10718431 PMID:16890076
RGD:5147813 , RGD:8547658
NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
G
RT1-Bb
RT1 class II, locus Bb
susceptibility
ISO
associated with intrinsic asthma;DNA:polymorphism, haplotype:cds:HLA-DQB1*0202 (human) DNA:haplotype: : HLA-DQB1*0201;
RGD
PMID:10718431 PMID:16890076
RGD:5147813 , RGD:8547658
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
G
RT1-CE13
RT1 class I, locus CE13
susceptibility
ISO
DNA:polymorphisms:cds:HLA-B*07, HLA-B*57 (human, Turkish)
RGD
PMID:18922348
RGD:7364876
NCBI chr20:3,314,830...3,318,106
G
RT1-Db1
RT1 class II, locus Db1
ISO
associated with intrinsic asthma;DNA:polymorphisms:cds:HLA-DR7 (human)
RGD
PMID:10718431
RGD:5147813
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
G
Sod1
superoxide dismutase 1
ISO
mRNA, protein:increased expression:middle nasal turbinate, lamella (human) associated with Rhinosinusitis;protein:decreased expression:nasal mucosa:
RGD
PMID:16540901 PMID:23921602
RGD:1581230 , RGD:8547534
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
G
Sod2
superoxide dismutase 2
ISO
associated with Rhinosinusitis;mRNA,protein:decreased expression:nasal mucosa:
RGD
PMID:23921602
RGD:8547534
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
G
Sod3
superoxide dismutase 3
ISO
mRNA, protein:increased expression:middle nasal turbinate, lamella (human)
RGD
PMID:16540901
RGD:1581230
NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
G
Stat3
signal transducer and activator of transcription 3
ISO
RGD
PMID:22959364
RGD:8694314
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
G
Tgfb1
transforming growth factor, beta 1
ISO
associated with Rhinitis mRNA:decreased expression:nasal cavity epithelium
RGD
PMID:18423831 PMID:23406597 PMID:12761968
RGD:4145277 , RGD:7394852 , RGD:7394830
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Tlr2
toll-like receptor 2
ISO
associated with Cystic Fibrosis;mRNA:increased expression:inferior nasal concha:
RGD
PMID:15836755
RGD:8552992
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
G
Tlr4
toll-like receptor 4
ISO
associated with Rhinosinusitis;mRNA,protein:increased expression:
RGD
PMID:23157229
RGD:7800741
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Tlr7
toll-like receptor 7
ISO
associated with Rhinosinusitis;mRNA,protein:increased expression:
RGD
PMID:23157229
RGD:7800741
NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754
G
Tnc
tenascin C
ISO
protein:increased expression:nasal cavity epithelium
RGD
PMID:12916355
RGD:4889591
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
G
Tnf
tumor necrosis factor
ISO
DNA:SNPs:promoter:
RGD
PMID:17638785
RGD:4142855
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnfrsf1a
TNF receptor superfamily member 1A
ISO
mRNA:decreased expression:nasal polyp (human)
RGD
PMID:19095579
RGD:5131442
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
G
Tnfrsf1b
TNF receptor superfamily member 1B
ISO
mRNA:decreased expression:nasal polyp (human)
RGD
PMID:19095579
RGD:5131442
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
G
Vegfa
vascular endothelial growth factor A
ISO
protein:increased expression:Turbinates:
RGD
PMID:12761968
RGD:7394830
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Abcb1a
ATP binding cassette subfamily B member 1A
severity
ISO
Nasal Type;protein:increased expression:nasal cavity (human)
RGD
PMID:18756548
RGD:8657087
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Cd274
CD274 molecule
disease_progression
ISO
associated with Epstein-Barr Virus Infections
RGD
PMID:27595782
RGD:41412182
NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
G
Cflar
CASP8 and FADD-like apoptosis regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15924153
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
G
Fas
Fas cell surface death receptor
ISO
DNA:insertion, deletions:cds:multiple (human)
RGD
PMID:12466128
RGD:8662407
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Gpx3
glutathione peroxidase 3
treatment
ISO
associated with ethmoid sinus cancer and Neoplasm Metastasis
RGD
PMID:29496492
RGD:151708712
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
G
Jak3
Janus kinase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22705984 PMID:23689514
NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
G
Prdm1
PR/SET domain 1
disease_progression
ISO
RGD
PMID:24438193
RGD:150530467
NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
G
Stat3
signal transducer and activator of transcription 3
ISO
protein:increased expression:nasal cavity (human)
RGD
PMID:17225522
RGD:153298933
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
G
Stat5b
signal transducer and activator of transcription 5B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29200404
NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
G
Dmbt1
deleted in malignant brain tumors 1
IEP
mRNA, Protein:increased expression
RGD
PMID:12419858
RGD:1599782
NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478
G
Mmp2
matrix metallopeptidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16178123
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
G
Anxa1
annexin A1
ISO
RGD
PMID:20970165
RGD:7421559
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
G
Anxa2
annexin A2
disease_progression
ISO
RGD
PMID:20970165
RGD:7421559
NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
G
Tp53
tumor protein p53
treatment
ISO
DNA:mutations:cds:
RGD
PMID:22575263 PMID:23369851
RGD:8547763 , RGD:8547764
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Adipoq
adiponectin, C1Q and collagen domain containing
ISO
protein:decreased expression:serum
RGD
PMID:19725899
RGD:5686851
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
G
Alb
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19389874
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
G
Alox5ap
arachidonate 5-lipoxygenase activating protein
ISO
protein:increased expression:nasal turbinate
RGD
PMID:19364335
RGD:5147461
NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
G
Cat
catalase
ISO
protein:decreased expression:plasma
RGD
PMID:20493834
RGD:5130771
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccl2
C-C motif chemokine ligand 2
ISO
protein:increased expression:nasal turbinate, mucosa (human)
RGD
PMID:9865755
RGD:8548839
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Ccr2
C-C motif chemokine receptor 2
ISO
mRNA:increased expression:Nasal Mucosa
RGD
PMID:17982926
RGD:4145109
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
G
Ccr5
C-C motif chemokine receptor 5
ISO
mRNA:increased expression:nasal mucosa (human)
RGD
PMID:17982926
RGD:4145109
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
G
Cd40
CD40 molecule
ISO
RGD
PMID:20226305
RGD:5132269
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
G
Cd86
CD86 molecule
ISO
protein:increased expression:nasal mucosa, dendritic cell (human)
RGD
PMID:17088138
RGD:4892343
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
G
Chia
chitinase, acidic
ISO
mRNA, protein:increased expression:turbinate, mucosa (human)
RGD
PMID:20422678
RGD:5037226
NCBI chr 2:193,614,374...193,656,532
Ensembl chr 2:193,614,114...193,656,533
G
Egr1
early growth response 1
ISO
DNA:snp:5' utr:g.-4071A>G rs7729723 (human)
RGD
PMID:19833116
RGD:5131984
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
G
F2rl1
F2R like trypsin receptor 1
ISO
RGD
PMID:17727088
RGD:4892590
NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
G
Gstp1
glutathione S-transferase pi 1
susceptibility
ISO
DNA:polymorphism:exon:p.I105V (rs1695) (human)
RGD
PMID:17181111
RGD:4142523
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Hmox1
heme oxygenase 1
ISO
mRNA, protein:increased expression: nasal mucosa
RGD
PMID:16540907
RGD:4145406
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Icam1
intercellular adhesion molecule 1
ISO
protein:increased expression:lung, endothelium (mouse) protein:increased secretion:nasopharynx (human)
RGD
PMID:19968652 PMID:19047814
RGD:4145464 , RGD:4145520
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Ifngr1
interferon gamma receptor 1
ISO
DNA: SNP: Leu467Pro
RGD
PMID:12851715
RGD:6480431
NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
G
Il13
interleukin 13
ISO
mRNA, protein:increased expression:nasal mucosa
RGD
PMID:8520776
RGD:4782826
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
G
Il17a
interleukin 17A
severity
ISO
protein:increased expression:serum
RGD
PMID:19226302
RGD:4889151
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
G
Il18
interleukin 18
susceptibility
ISO
DNA:SNP:promoter:c. -607A>C (rs1946518) (human)
RGD
PMID:16406079
RGD:4889924
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il1a
interleukin 1 alpha
ISO
DNA:polymorphism:exon:c.4845G>T (human)
RGD
PMID:14533660
RGD:4142859
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il1r1
interleukin 1 receptor type 1
ISO
RGD
PMID:18637763
RGD:5037238
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
G
Il2
interleukin 2
ISO
protein:decreased expression:serum:
RGD
PMID:17608155
RGD:8662959
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Il4
interleukin 4
treatment
ISO
protein:increased expression:serum
RGD
PMID:21171297 PMID:9237816 PMID:15329007
RGD:5128559 , RGD:7829817 , RGD:7829804
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Il5
interleukin 5
ISO
protein: increased levels: sputum
RGD
PMID:22186238
RGD:5687140
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
G
Mmp2
matrix metallopeptidase 2
ISO
protein:increased expression:nasal mucosa:
RGD
PMID:19786210
RGD:5130872
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
G
Mmp9
matrix metallopeptidase 9
ISO
protein:increased expression:nasal mucosa:
RGD
PMID:19786210
RGD:5130872
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Nos2
nitric oxide synthase 2
ISO
protein:increased expression:nasal mucosa
RGD
PMID:14587983
RGD:4892078
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nos3
nitric oxide synthase 3
ISO
DNA:snp:promoter:g.-786T>C (human)
RGD
PMID:18086269
RGD:4892054
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
ISO
protein:altered expression:nasal mucosa
RGD
PMID:20185258
RGD:4892593
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
G
Pparg
peroxisome proliferator-activated receptor gamma
ISO
mRNA, protein:increased expression:nasal mucosa (human)
RGD
PMID:17116814
RGD:8552811
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ptgs1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:respiratory system epithelium
RGD
PMID:19364335
RGD:5147461
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
G
Tbxa2r
thromboxane A2 receptor
treatment
ISO
RGD
PMID:15247523
RGD:11059532
NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176
G
Adam33
ADAM metallopeptidase domain 33
susceptibility
ISO
DNA:SNPs: :multiple (human)
RGD
PMID:18778489 PMID:15298558
RGD:4145378 , RGD:4145383
NCBI chr 3:118,262,395...118,283,456
Ensembl chr 3:118,271,029...118,283,461
G
Ang
angiogenin
ISO
protein:increased expression:sputum
RGD
PMID:19178538
RGD:6892723
NCBI chr15:24,312,711...24,323,361
G
Bdkrb1
bradykinin receptor B1
ISO
RGD
PMID:12165532
RGD:5129220
NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
G
Bdkrb2
bradykinin receptor B2
ISO
RGD
PMID:1890650 PMID:11149999
RGD:4891044 , RGD:4891033
NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
G
Bdnf
brain-derived neurotrophic factor
susceptibility
IEP ISO
mRNA:increased expression:nasal cavity epithelium DNA:SNP,haplotypes: :rs10767664,rs12273539,rs962369(human)
RGD
PMID:20464992 PMID:21723144
RGD:4891116 , RGD:8655967
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
G
C3
complement C3
ISO IEP
mRNA:increased expression:nasal cavity epithelium
RGD
PMID:20109314 PMID:17345707
RGD:5129539 , RGD:5129524
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
G
C3ar1
complement C3a receptor 1
severity
ISO
protein:increased expression:nasal cavity
RGD
PMID:18538384
RGD:5129559
NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701
G
C5ar1
complement C5a receptor 1
ISO
RGD
PMID:18538384
RGD:5129559
NCBI chr 1:76,948,622...76,959,826
G
Casp1
caspase 1
ISO
protein:increased expression:serum
RGD
PMID:12396474 PMID:20974310
RGD:5130192 , RGD:5130187
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
G
Cat
catalase
treatment
ISO
protein:increased activity:blood,nasal cavity mucosa:
RGD
PMID:21541033
RGD:9479054
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccl1
C-C motif chemokine ligand 1
ISO
mRNA:increased expression:nasal cavity epithelium
RGD
PMID:17982926
RGD:4145109
NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
G
Ccl11
C-C motif chemokine ligand 11
severity
ISO IEP
associated with Sinusitis;protein:increased expression:paranasal sinus protein:increased expression:nasal mucus mRNA:increased expression:lung, nose
RGD
PMID:17999785 PMID:16120080 PMID:16765544
RGD:4145455 , RGD:4145411 , RGD:4145462
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
G
Ccl17
C-C motif chemokine ligand 17
ISO
protein:increased expression:blood, mononuclear cell
RGD
PMID:17517104
RGD:4145498
NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819
G
Ccl19
C-C motif chemokine ligand 19
ISO
RGD
PMID:17947663
RGD:5130909
NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
G
Ccl22
C-C motif chemokine ligand 22
ISO
protein:increased expression:blood, mononuclear cell
RGD
PMID:17517104
RGD:4145498
NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
G
Ccl24
C-C motif chemokine ligand 24
ISO
mRNA:increased expression:nasal cavity epithelium DNA:SNPs: :179T>C, 275C>T (human)
RGD
PMID:17982926 PMID:15580493
RGD:4145109 , RGD:4891493
NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893
G
Ccl26
C-C motif chemokine ligand 26
ISO
DNA:polymorphism: :2497T>G (human) associated with Eosinophilia;protein:increased expression:oronasal secretion (human)
RGD
PMID:15580493 PMID:24989688
RGD:4891493 , RGD:11531119
NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335
G
Ccl4
C-C motif chemokine ligand 4
ISO
RGD
PMID:19786211
RGD:5130914
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
G
Ccl7
C-C motif chemokine ligand 7
ISO
RGD
PMID:17982926
RGD:4145109
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
G
Ccr2
C-C motif chemokine receptor 2
susceptibility
ISO
Rhinitis, Allergic, Seasonal; DNA:SNP:cds:p.V64I (human)
RGD
PMID:17135764
RGD:4145111
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
G
Ccr3
C-C motif chemokine receptor 3
ISO IEP
DNA:SNP:exon:51T>C (human) protein:increased expression:blood, T cell mRNA:increased expression:nose
RGD
PMID:17135764 PMID:17156343 PMID:20696593
RGD:4145111 , RGD:4145645 , RGD:4145454
NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
G
Cd14
CD14 molecule
susceptibility resistance
ISO
DNA:polymorphism:promoter:c. -159c>T (human)
RGD
PMID:20109306 PMID:16950285
RGD:4144795 , RGD:4144810
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
G
Cd28
Cd28 molecule
ISO
RGD
PMID:21356099
RGD:5131612
NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
G
Cd80
Cd80 molecule
ISO
RGD
PMID:21108691
RGD:5132622
NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
G
Cdc42
cell division cycle 42
ISO
mRNA:increased expression:nasal turbinate
RGD
PMID:19432938
RGD:5688273
NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
G
Cftr
CF transmembrane conductance regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16083808
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
G
Crhr1
corticotropin releasing hormone receptor 1
ISO
mRNA, protein:increased expression:nasal cavity epithelium
RGD
PMID:17597629
RGD:5130940
NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
G
Crhr2
corticotropin releasing hormone receptor 2
ISO
mRNA, protein:increased expression:nasal cavity epithelium
RGD
PMID:17597629
RGD:5130940
NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
G
Ctla4
cytotoxic T-lymphocyte-associated protein 4
ISO
protein:increased expression:T cell
RGD
PMID:17625281
RGD:4891512
NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
G
Cx3cl1
C-X3-C motif chemokine ligand 1
ISO
protein:increased expression:plasma
RGD
PMID:14657873
RGD:4891906
NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
G
Cxcl6
C-X-C motif chemokine ligand 6
ISO
protein:increased expression:nasal mucus
RGD
PMID:20659080
RGD:4892030
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
ISO
DNA:SNP:3' utr:*1934G>A (human)
RGD
PMID:20088379
RGD:5143945
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Cysltr1
cysteinyl leukotriene receptor 1
ISO
associated with Sinusitis;mRNA:increased expression:nasal cavity epithelium
RGD
PMID:17627772 PMID:16689996 PMID:15379985 PMID:18946234
RGD:4781451 , RGD:4783198 , RGD:4847512 , RGD:4888516
NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121
G
Cysltr2
cysteinyl leukotriene receptor 2
ISO
associated with Sinusitis;mRNA:increased expression:nasal cavity epithelium
RGD
PMID:16689996
RGD:4783198
NCBI chr15:48,189,476...48,228,750
Ensembl chr15:48,189,073...48,304,136
G
Fcer1a
Fc epsilon receptor Ia
ISO
RGD
PMID:20650300
RGD:5128714
NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351
G
Fis1
fission, mitochondrial 1
IEP
mRNA, protein:increased expression:nasal cavity mucosa (rat)
RGD
PMID:28146064
RGD:13204839
NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
G
Hdc
histidine decarboxylase
ISO IEP
DNA:SNP: :p.E644D (rs2073440) (human)
RGD
PMID:20608921 PMID:15054596
RGD:5128884 , RGD:5143921
NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
G
Hnmt
histamine N-methyltransferase
no_association
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:17651147 PMID:17651147
RGD:5128885
NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
G
Hrh1
histamine receptor H 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12167471
NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
G
Il13
interleukin 13
susceptibility disease_progression
ISO IEP
associated with asthma; DNA:polymorphisms:promoter:c. -1510A>C, -1055C>T (human) mRNA:increased expression:nose DNA:polymorphism: :rs1800925 (human)
RGD
PMID:16120094 PMID:20358028 PMID:20696593 PMID:17088137 PMID:20484924
RGD:4206706 , RGD:4145767 , RGD:4145454 , RGD:4159171 , RGD:4145534
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
G
Il13ra2
interleukin 13 receptor subunit alpha 2
ISO
RGD
PMID:17088137
RGD:4159171
NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381
G
Il15
interleukin 15
ISO
RGD
PMID:16750998
RGD:5000756
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
G
Il16
interleukin 16
ISO
protein:increased expression:serum protein:increased expression:nasal cavity epithelium, serum
RGD
PMID:18254318 PMID:19295235
RGD:5024932 , RGD:5024931
NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
G
Il17a
interleukin 17A
ISO
protein:increased expression:nasal mucosa
RGD
PMID:20506642 PMID:19927541
RGD:4889137 , RGD:4889144
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
G
Il18
interleukin 18
disease_progression
ISO
protein:increased expression:nasal lavage fluid, bronchoalveolar lavage fluid protein:increased expression:serum rhinitis allergic, seasonal; protein:increased expression:plasma
RGD
PMID:17305282 PMID:17323858 PMID:15934281
RGD:4889917 , RGD:4889916 , RGD:4889927
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il1b
interleukin 1 beta
susceptibility
IEP ISO
mRNA:increased expression:nasal cavity epithelium associated with Hypersensitivity;DNA:polymorphism: :-511C>T (human) associated with Hypersensitivity;protein:increased expression:nasal mucus
RGD
PMID:20490816 PMID:14533660 PMID:10224452
RGD:4142821 , RGD:4142859 , RGD:4143227
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il1rl1
interleukin 1 receptor-like 1
severity
ISO
associated with Sinusitis;DNA:SNPs: :multiple (human)
RGD
PMID:19671251
RGD:5144228
NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
G
Il1rn
interleukin 1 receptor antagonist
susceptibility
ISO
associated with Hypersensitivity;DNA:repeat:intron (human)
RGD
PMID:14533660 PMID:15178892 PMID:10224452
RGD:4142859 , RGD:4143215 , RGD:4143227
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
G
Il2
interleukin 2
susceptibility
ISO
DNA:SNP:promoter:rs2069762(human)
RGD
PMID:16333313
RGD:8663473
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Il21
interleukin 21
ISO
RGD
PMID:17982108
RGD:5147397
NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996
G
Il22
interleukin 22
severity
ISO
mRNA:increased expression:blood, mononuclear cell
RGD
PMID:21535180
RGD:5147409
NCBI chr 7:53,801,206...53,805,673
Ensembl chr 7:53,801,206...53,806,186
G
Il23r
interleukin 23 receptor
susceptibility
ISO
DNA:SNP,haplotype: :rs7517847(human)
RGD
PMID:23696856
RGD:8549605
NCBI chr 4:96,580,568...96,672,540
Ensembl chr 4:96,580,714...96,674,021
G
Il27ra
interleukin 27 receptor subunit alpha
ISO
RGD
PMID:19354069
RGD:5128480
NCBI chr19:24,109,963...24,121,977
Ensembl chr19:24,109,972...24,121,938
G
Il4
interleukin 4
ISO IEP
mRNA:increased expression:nasal cavity epithelium CTD Direct Evidence: marker/mechanism protein:increased expression:serum
CTD RGD
PMID:19672097 PMID:21208219 PMID:18826099
RGD:5128558 , RGD:2317285
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Il4r
interleukin 4 receptor
ISO
DNA:polymorphism: :c.1432T>C (human)
RGD
PMID:15564773
RGD:4890394
NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
G
Il5
interleukin 5
ISO
RGD
PMID:11884474
RGD:5128622
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
G
Il9
interleukin 9
ISO
RGD
PMID:20525149
RGD:5128687
NCBI chr17:8,111,772...8,114,895
Ensembl chr17:8,111,772...8,114,895
G
Lep
leptin
ISO
RGD
PMID:19860581
RGD:5128850
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
G
Mbl2
mannose binding lectin 2
susceptibility
ISO
DNA:polymorphism: :
RGD
PMID:18831943
RGD:8693717
NCBI chr 1:228,016,439...228,024,736
G
Mfn1
mitofusin 1
IEP
mRNA, protein:increased expression:nasal cavity mucosa (rat)
RGD
PMID:28146064
RGD:13204839
NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
G
Mif
macrophage migration inhibitory factor
severity
ISO
protein:increased expression:serum, nasal mucosa
RGD
PMID:15053202 PMID:15922619
RGD:4891045 , RGD:4891056
NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
G
Ms4a2
membrane spanning 4-domains A2
ISO
RGD
PMID:15480314
RGD:5131152
NCBI chr 1:208,440,179...208,448,716
Ensembl chr 1:208,440,361...208,448,310
G
Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
IEP ISO
mRNA:increased expression:nose
RGD
PMID:20696593 PMID:15715404
RGD:4145454 , RGD:7364740
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
G
Ngf
nerve growth factor
ISO
protein:increased expression:respiratory system fluid/secretion associated with Sinusitis;protein:increased expression:respiratory system mucosa
RGD
PMID:10224365 PMID:19958603
RGD:4891115 , RGD:4891064
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
G
Ngfr
nerve growth factor receptor
ISO
protein:increased expression:blood, eosinophil
RGD
PMID:18647313
RGD:5144116
NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
G
Nod1
nucleotide-binding oligomerization domain containing 1
ISO
mRNA:decreased expression:nose
RGD
PMID:20384614
RGD:5131446
NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
G
Nod2
nucleotide-binding oligomerization domain containing 2
susceptibility
ISO
DNA:polymorphisms:cds:2104C>T,2722G>C (human)
RGD
PMID:12704363
RGD:5131484
NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
G
Nos2
nitric oxide synthase 2
ISO
protein:increased expression:nasal mucosa
RGD
PMID:18254476
RGD:4891910
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Npy
neuropeptide Y
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12746121
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
G
Ntrk1
neurotrophic receptor tyrosine kinase 1
ISO
protein:increased expression:eosinophil
RGD
PMID:18647313
RGD:5144116
NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
G
Opa1
OPA1, mitochondrial dynamin like GTPase
IEP
mRNA, protein:increased expression:nasal cavity mucosa (rat)
RGD
PMID:28146064
RGD:13204839
NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
G
Plau
plasminogen activator, urokinase
ISO
mRNA:increased expression:nasal cavity epithelium
RGD
PMID:21339035
RGD:8547809
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
G
Ptgdr2
prostaglandin D2 receptor 2
ISO
RGD
PMID:19230460 PMID:19608418
RGD:5135021 , RGD:5135017
NCBI chr 1:207,585,088...207,590,275
Ensembl chr 1:207,587,917...207,589,213
G
RT1-Ba
RT1 class II, locus Ba
susceptibility
ISO
DNA:polymorphisms:cds:HLA-DQA1*0201, HLA-DQA1*0302 (human)
RGD
PMID:14990915
RGD:5147798
NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
G
RT1-Bb
RT1 class II, locus Bb
susceptibility
ISO
DNA:polymorphism:cds:HLA-DQB1*0602 (human)
RGD
PMID:14990915
RGD:5147798
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
G
Scgb3a2
secretoglobin, family 3A, member 2
ISO
protein:increased expression:sputum mRNA,protein:decreased expression:nasal mucosa
RGD
PMID:17218572 PMID:21385388
RGD:5144232 , RGD:5147389
NCBI chr18:35,932,840...35,935,762
Ensembl chr18:35,932,840...35,935,762
G
Serpine1
serpin family E member 1
susceptibility
ISO
DNA:polymorphism:promoter:rs1799768 (human)
RGD
PMID:19063817
RGD:4144832
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
G
Sftpd
surfactant protein D
susceptibility
ISO
associated with Hypersensitivity;DNA:polymorphism: :p.M11T (human)
RGD
PMID:19493231
RGD:4143494
NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
G
Tap1
transporter 1, ATP binding cassette subfamily B member
susceptibility no_association
ISO
DNA:SNPs: :
RGD
PMID:17982230 PMID:12018331
RGD:6482262 , RGD:6482274
NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901
G
Tbxa2r
thromboxane A2 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12167471
NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176
G
Tgfb1
transforming growth factor, beta 1
ISO
associated with Sinusitis
RGD
PMID:18423831
RGD:4145277
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Tlr2
toll-like receptor 2
susceptibility no_association
ISO
DNA:SNPs: :597T>C, 1350T>C (human) mRNA:decreased expression:nasal mucosa: associated with Sinusitis;DNA:SNPs: :multiple (human)
RGD
PMID:19763595 PMID:18219831 PMID:19128592
RGD:4145354 , RGD:7800742 , RGD:4145356
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
G
Tlr6
toll-like receptor 6
ISO
associated with Asthma;DNA:SNP: :rs2381289 (human)
RGD
PMID:20815312
RGD:4145352
NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
G
Tnf
tumor necrosis factor
ISO IEP
mRNA:increased expression:nose
RGD
PMID:15120189 PMID:20696593
RGD:4143470 , RGD:4145454
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Vegfa
vascular endothelial growth factor A
ISO
protein:increased expression:sputum
RGD
PMID:19178538
RGD:6892723
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Vip
vasoactive intestinal peptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12746121 PMID:14680090
NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
G
RT1-Ba
RT1 class II, locus Ba
susceptibility
ISO
DNA:haplotype: :
RGD
PMID:17321882
RGD:8547664
NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
G
RT1-Bb
RT1 class II, locus Bb
susceptibility
ISO
DNA:haplotype: :
RGD
PMID:17321882
RGD:8547664
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
G
Anxa1
annexin A1
ISO
associated with Nasal Polyps
RGD
PMID:22279949
RGD:7421555
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
G
C3
complement C3
ISO
protein:increased expression:serum
RGD
PMID:19593977
RGD:4889484
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
G
C4a
complement C4A
disease_progression
ISO
DNA:deletion: :
RGD
PMID:16879240
RGD:5688262
NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080
G
Ccl20
C-C motif chemokine ligand 20
ISO
RGD
PMID:16702571
RGD:7483585
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
G
Hgf
hepatocyte growth factor
susceptibility
ISO
DNA:haplotype::rs38850,rs38855,rs38857(human)
RGD
PMID:20416453
RGD:8548615
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
G
Igf1
insulin-like growth factor 1
ISO
mRNA:increased expression:nose:
RGD
PMID:20713758
RGD:8548883
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Il10
interleukin 10
ISO
protein:decreased expression:blood, mononuclear cell
RGD
PMID:23168151
RGD:7364820
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il17a
interleukin 17A
ISO
associated with Asthma;mRNA, protein:increased expression:nasal polyps (human)
RGD
PMID:19672092
RGD:4889146
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
G
Il1b
interleukin 1 beta
ISO
protein:increased expression:nasal cavity epithelium
RGD
PMID:11197112
RGD:7401169
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il22ra1
interleukin 22 receptor subunit alpha 1
susceptibility
ISO
DNA:SNPs:5' utr, intron: (rs4292900, rs16829225, rs4648936) (human)
RGD
PMID:19393422
RGD:5147411
NCBI chr 5:147,961,496...147,986,296
Ensembl chr 5:147,961,349...147,986,296
G
Il4
interleukin 4
treatment
ISO
associated with Asthma
RGD
PMID:12787306
RGD:7829803
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Mmp9
matrix metallopeptidase 9
ISO
RGD
PMID:23401274
RGD:8547880
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
treatment
IDA
RGD
PMID:23131200 PMID:19389874
RGD:7349403 , RGD:7364734
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
G
Prkra
protein activator of interferon induced protein kinase EIF2AK2
severity
ISO
associated with Nasal Polyps
RGD
PMID:22961479
RGD:7777146
NCBI chr 3:61,575,447...61,594,393
Ensembl chr 3:61,575,447...61,594,347
G
Serpine1
serpin family E member 1
ISO
protein:increased expression:nasal mucosa (human)
RGD
PMID:21711960
RGD:6483796
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
G
Tlr2
toll-like receptor 2
susceptibility
ISO
mRNA,protein:increased expression:paranasal sinus DNA:polymorphisms:: rs3804099,rs3804100(human)
RGD
PMID:22182736 PMID:21493395
RGD:7800733 , RGD:8552975
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
G
Tlr4
toll-like receptor 4
ISO
mRNA,protein:increased expression:paranasal sinus
RGD
PMID:22182736
RGD:7800733
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Tnf
tumor necrosis factor
ISO
protein:increased expression:nasal cavity epithelium
RGD
PMID:11197112 PMID:20147558
RGD:7401169 , RGD:7401236
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
RT1-Bb
RT1 class II, locus Bb
ISO
DNA:polymorphisms, haplotypes:cds:HLA-DQB1*0301, HLA-DQB1*0302 (human)
RGD
PMID:15577839
RGD:5147654
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
G
Alox5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:16677242
RGD:5147463
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
G
Apoa4
apolipoprotein A4
resistance
ISO
protein:increased expression:blood serum (human)
RGD
PMID:20810159
RGD:5685642
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
G
Bdnf
brain-derived neurotrophic factor
severity
ISO
protein:increased expression:blood, nasal cavity epithelium
RGD
PMID:18266897
RGD:5144117
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
G
Ccl5
C-C motif chemokine ligand 5
ISO
protein:increased expression:inferior turbinate, epithelium (human)
RGD
PMID:20459697
RGD:4891379
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
G
Cma1
chymase 1
ISO
protein:increased expression:nasal mucosa, mast cell (human)
RGD
PMID:11549546
RGD:5128839
NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
G
Fga
fibrinogen alpha chain
ISO
RGD
PMID:21887273
RGD:5688767
NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
G
Gsto1
glutathione S-transferase omega 1
ISO
protein:decreased expression;T lymphocyte:
RGD
PMID:21410266
RGD:5491008
NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
G
Icam1
intercellular adhesion molecule 1
ISO
protein:increased secretion:nasopharynx, secretion (human)
RGD
PMID:20128420
RGD:4145459
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Ifngr1
interferon gamma receptor 1
ISO
DNA: SNP: Leu467Pro
RGD
PMID:12851715
RGD:6480431
NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
G
Il10
interleukin 10
treatment
ISO
RGD
PMID:19505388
RGD:7365025
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il18
interleukin 18
susceptibility no_association
ISO
DNA:SNPs:promoters, exon:multiple DNA:SNPs:promoters:multiple
RGD
PMID:12532106 PMID:12532106
RGD:8655871 , RGD:8655871
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il4
interleukin 4
ISO
protein:increased expression:serum mRNA:increased expression:nose:
RGD
PMID:9237816 PMID:7551298
RGD:7829817 , RGD:8662960
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Kdr
kinase insert domain receptor
ISO
protein:increased expression:nasal cavity of mucosa:
RGD
PMID:17651148
RGD:8551771
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
G
Mc1r
melanocortin 1 receptor
no_association
ISO
RGD
PMID:20357480
RGD:5687317
NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
G
Mmp9
matrix metallopeptidase 9
ISO
DNA:SNPs:promoter, intron, cds:-1590C>T, 2127G>T, p.R668Q (rs3918242, rs2274755, rs17577) (human)
RGD
PMID:22237587
RGD:8547819
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Nod1
nucleotide-binding oligomerization domain containing 1
susceptibility
ISO
DNA:SNP: :rs2075817 (human)
RGD
PMID:16918516
RGD:5131519
NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
G
Nod2
nucleotide-binding oligomerization domain containing 2
susceptibility
ISO
DNA:polymorphisms:5'UTR/exon, exon:rs5743266, rs2066842 (human)
RGD
PMID:16008671
RGD:5131477
NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
G
Ptgs1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:respiratory system epithelium
RGD
PMID:19364335
RGD:5147461
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
G
RT1-Bb
RT1 class II, locus Bb
susceptibility
ISO
DNA:polymorphism:cds:HLA-DQB1*05 (human) DNA:polymorphisms, haplotype:cds:HLA-DQB1*0301, HLA-DQB1*0501 (human)
RGD
PMID:22032123 PMID:9641569
RGD:7421561 , RGD:7421576
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
G
Scgb1a1
secretoglobin family 1A member 1
ISO
mRNA, protein:decreased expression:nasal lavage fluid
RGD
PMID:15836756
RGD:5144234
NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610
G
Tlr3
toll-like receptor 3
ISO
protein:decreased expression:bone marrow, blood, eosinophil (human)
RGD
PMID:19752565
RGD:5129130
NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
G
Tlr4
toll-like receptor 4
susceptibility
ISO
DNA:polymorphisms:cds:p.D299G, T399I (human)
RGD
PMID:18517079
RGD:4144192
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Vegfa
vascular endothelial growth factor A
ISO
mRNA,protein:increased expression:nasal biopsies,nasal lavage fluid:
RGD
PMID:12633568
RGD:7483595
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Maml3
mastermind-like transcriptional coactivator 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24859338
NCBI chr 2:135,720,431...136,137,829
Ensembl chr 2:135,721,021...136,137,814
G
Pax3
paired box 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24859338
NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042
G
Smarcb1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
ISO
RGD
PMID:30120966
RGD:127285653
NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620
G
Azgp1
alpha-2-glycoprotein 1, zinc-binding
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18391768
NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091
G
Ccl4
C-C motif chemokine ligand 4
ISO
RGD
PMID:19786211
RGD:5130914
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
G
Cfb
complement factor B
ISO
protein:decreased expression:serum
RGD
PMID:14510109
RGD:7411729
NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
G
Cftr
CF transmembrane conductance regulator
susceptibility
ISO
DNA:mutations: : CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:16083808 PMID:11773581
RGD:4140477
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
G
Chia
chitinase, acidic
severity
ISO
mRNA:decreased expression:sinus, epithelial cell (human)
RGD
PMID:19379605
RGD:5037227
NCBI chr 2:193,614,374...193,656,532
Ensembl chr 2:193,614,114...193,656,533
G
Cxcl6
C-X-C motif chemokine ligand 6
ISO
associated with Rhinitis;mRNA:increased expression:paranasal sinus
RGD
PMID:19153309
RGD:5135257
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
G
Il13
interleukin 13
susceptibility
ISO
associated with asthma; DNA:polymorphisms:promoter:c. -1510A>C, -1055C>T (human) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:20358028 PMID:20358028
RGD:4145767
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
G
Il1b
interleukin 1 beta
ISO
associated with Hypersensitivity
RGD
PMID:16358839
RGD:4143214
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il2
interleukin 2
ISO
RGD
PMID:11758471
RGD:8662964
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Lta
lymphotoxin alpha
susceptibility
ISO
DNA:polymorphism: :
RGD
PMID:11037831
RGD:4143260
NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
G
Met
MET proto-oncogene, receptor tyrosine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18391768
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
G
Mmp9
matrix metallopeptidase 9
ISO
protein:increased expression::
RGD
PMID:20392482
RGD:5130763
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Muc5b
mucin 5B, oligomeric mucus/gel-forming
ISO
protein:increased secretion:sinus mucus
RGD
PMID:17063754
RGD:5131192
NCBI chr 1:196,916,861...196,948,830
Ensembl chr 1:196,916,825...196,949,250
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
ISO
RGD
PMID:18396779
RGD:4892328
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
G
Pdgfb
platelet derived growth factor subunit B
ISO
protein: increased expression: nasal cavity epithelium
RGD
PMID:21255638
RGD:6483060
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
G
Pip
prolactin induced protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18391768
NCBI chr 4:70,787,627...70,791,921
Ensembl chr 4:70,787,627...70,791,921
G
Plau
plasminogen activator, urokinase
ISO
RGD
PMID:21711960
RGD:6483796
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
G
Plaur
plasminogen activator, urokinase receptor
ISO
RGD
PMID:21711960
RGD:6483796
NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
G
Ppp1r9b
protein phosphatase 1, regulatory subunit 9B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18391768
NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083
G
Scgb3a2
secretoglobin, family 3A, member 2
ISO
mRNA,protein:decreased expression:nasal mucosa
RGD
PMID:21385388
RGD:5147389
NCBI chr18:35,932,840...35,935,762
Ensembl chr18:35,932,840...35,935,762
G
Sftpa1
surfactant protein A1
ISO
associated with Cystic Fibrosis;mRNA:increased expression:respiratory system mucosa
RGD
PMID:17599561
RGD:4143506
NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685
G
Sftpd
surfactant protein D
ISO
associated with Cystic Fibrosis;mRNA:increased expression:respiratory system mucosa
RGD
PMID:17599561
RGD:4143506
NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
G
Tlr2
toll-like receptor 2
ISO
mRNA:increased expression:nasal cavity epithelium:
RGD
PMID:14743629
RGD:8552991
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
G
Tlr4
toll-like receptor 4
ISO
associated with Pneumococal Infections; mRNA:increased expression:nasal cavity epithelium:
RGD
PMID:16301373 PMID:14743629
RGD:7800729 , RGD:8552991
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Tlr9
toll-like receptor 9
ISO
Chronic Sinusitis; protein:decreased expression:nasal mucosa, epithelial cell (human) Acute Sinusitis; protein:decreased expression:nasal mucosa, epithelial cell (human)
RGD
PMID:17283572 PMID:18416964
RGD:5130870 , RGD:5130708
NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all