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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:prostate adenocarcinoma
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Accession:DOID:2526 term browser browse the term
Definition:A prostate carcinoma that derives_from epithelial cells of glandular origin. (DO)
Synonyms:exact_synonym: adenocarcinoma of prostate;   prostatic adenocarcinoma
 alt_id: MIM:601188
 xref: EFO:0000673;   NCI:C2919
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
prostate adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing susceptibility ISO DNA:SNPs, haplotypes:5' utr, introns, exon:multiple RGD PMID:21397927 RGD:8694410 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Adipor1 adiponectin receptor 1 susceptibility ISO DNA:SNPs, haplotype:intron, exon: (rs12733285, rs7539452) (human) RGD PMID:21397927 RGD:8694410 NCBI chr13:48,411,438...48,431,251
Ensembl chr13:48,411,826...48,431,255 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 treatment ISO RGD PMID:20638364 RGD:13504677 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 treatment ISO RGD PMID:20638364 RGD:13504677 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 treatment ISO RGD PMID:20638364 RGD:13504677 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020 		JBrowse link
G Ar androgen receptor treatment IDA RGD PMID:18439064 RGD:10043341 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Bin1 bridging integrator 1 ISO RGD PMID:12532338 RGD:1580047 NCBI chr18:24,282,840...24,341,461
Ensembl chr18:24,283,801...24,341,458 		JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 ameliorates ISO mRNA:increased expression:prostate gland (human) RGD PMID:31964418 RGD:153344516 NCBI chr 6:26,474,843...26,668,275
Ensembl chr 6:26,474,843...26,668,507 		JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 exacerbates ISO mRNALincreased expression:prostate gland (human) RGD PMID:31964418 RGD:153344516 NCBI chr 3:188,425,392...188,430,174
Ensembl chr 3:188,425,392...188,430,174 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:19079609 RGD:2315868 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931 		JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 treatment ISO RGD PMID:25003983 RGD:18337280 NCBI chr 5:155,958,116...155,959,897
Ensembl chr 5:155,957,878...155,961,058 		JBrowse link
G Ccnb1 cyclin B1 severity ISO RGD PMID:10193948 RGD:2315940 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccne2 cyclin E2 ISO RGD PMID:25315431 RGD:13504706 NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882 		JBrowse link
G Cd9 CD9 molecule disease_progression ISO DNA, mRNA:deletion, point mutation, decreased expression:prostate gland RGD PMID:17406028 RGD:2326197 NCBI chr 4:159,942,553...159,975,463
Ensembl chr 4:159,942,560...159,975,444 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 ISO mRNA:decreased expression:prostate gland (human) RGD PMID:28486105 RGD:153323299 NCBI chr 4:159,584,623...159,617,867
Ensembl chr 4:159,584,654...159,617,866 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex treatment ISO RGD PMID:26379052 RGD:13504774 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Clu clusterin treatment IEP RGD PMID:24118288 RGD:9068419 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 ISO RGD PMID:17270658 PMID:11830526 RGD:13504714, RGD:13504715 NCBI chr 2:177,987,981...177,994,568
Ensembl chr 2:177,987,981...177,993,485 		JBrowse link
G Ctnnb1 catenin beta 1 ISO ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:10192393 PMID:25741868 PMID:26619011 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO mRNA,protein:increased expression:prostate gland: RGD PMID:17178860 RGD:2289681 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha ISO mRNA:increased expression:prostate gland: RGD PMID:17178860 RGD:2289681 NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta ISO mRNA,protein:increased expression:prostate gland: RGD PMID:17178860 RGD:2289681 NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:162,604,037...162,629,313 		JBrowse link
G Fgf2 fibroblast growth factor 2 disease_progression ISO RGD PMID:14522896 RGD:2290290 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO RGD PMID:23576558 PMID:18068632 RGD:13504748, RGD:2298702 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:73,194,631...73,249,855 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO RGD PMID:26103942 RGD:11056009 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Adenocarcinoma of prostate | ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:1904555 PMID:3510078 PMID:11150980 PMID:16155195 PMID:16170316 More... NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 ISO ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20946881 More... NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:74,027,892...74,049,555 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor treatment
disease_progression 		ISO
IMP 		RGD PMID:26452103 PMID:25862373 PMID:25442907 PMID:8692980 RGD:13504753, RGD:13504767, RGD:13504768, RGD:13504771 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta treatment ISO RGD PMID:27196761 RGD:13504772 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Ilk integrin-linked kinase disease_progression ISO protein:increased expression:tumor: high-grade tumors versus adjacent BHP (P<0.001), BHP from cancer-free patients (P<0.002), or low-grade tumors (P=0.003), also associated with proliferative index (P=0.001), but inversely related to 5-year survival (p=0.004) (human) RGD PMID:11448915 RGD:2301734 NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:169,498,681...169,506,964 		JBrowse link
G Insr insulin receptor treatment ISO RGD PMID:26452103 RGD:13504753 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit disease_progression ISO RGD PMID:9748134 RGD:2290484 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Kdr kinase insert domain receptor ISO
IEP 		protein:increased expression:prostate gland RGD PMID:17491265 PMID:20808233 RGD:2291925, RGD:5684541 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 disease_progression IDA metastasis; inhibition reduced invasiveness of prostate tumor cells RGD PMID:12688676 RGD:2292631 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment ISO RGD PMID:28492138 PMID:22139534 RGD:13504818, RGD:13504820 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO human gene in mouse model RGD PMID:14522256 PMID:20195545 RGD:7207413, RGD:7207781 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ameliorates ISO human cells in mouse model RGD PMID:25664849 RGD:153002575 NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776 		JBrowse link
G Nfkbia NFKB inhibitor alpha severity ISO protein:increased serine phosphorylation RGD PMID:15712212 PMID:15073126 RGD:2298768, RGD:13506768 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase ISO mRNA:increased expression:prostate gland (human) RGD PMID:11221851 RGD:6483769 NCBI chr 9:105,445,812...105,719,287
Ensembl chr 9:105,445,929...105,719,285 		JBrowse link
G Pdgfa platelet derived growth factor subunit A ISO protein:increased expression:prostate RGD PMID:7524068 RGD:2292156 NCBI chr12:20,759,366...20,780,337
Ensembl chr12:20,754,208...20,780,322 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha ISO protein:increased expression:prostate RGD PMID:7524068 RGD:2292156 NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,360,028...33,408,516 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 treatment ISO RGD PMID:17562488 RGD:13506808 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO ClinVar Annotator: match by term: Adenocarcinoma of prostate ClinVar PMID:15016963 PMID:15254419 PMID:15647370 PMID:15805248 PMID:18676830 More... NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta treatment ISO RGD PMID:18755892 RGD:13217420 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331 		JBrowse link
G Prkcq protein kinase C, theta IEP mRNA:increased expression:prostate RGD PMID:8180127 RGD:1625625 NCBI chr17:72,156,215...72,288,508
Ensembl chr17:72,156,215...72,288,508 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase treatment ISO RGD PMID:15754006 RGD:13506897 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit disease_progression ISO protein:increased expression:prostate gland RGD PMID:15712212 PMID:15073126 RGD:2298768, RGD:13506768 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 disease_progression ISO protein:increased activity:prostate RGD PMID:9748134 RGD:2290484 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Tert telomerase reverse transcriptase treatment ISO RGD PMID:19903903 RGD:11038656 NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111 		JBrowse link
G Tmprss2 transmembrane serine protease 2 disease_progression ISO protein:increased expression, altered localization:prostate gland RGD PMID:18338334 RGD:2324904 NCBI chr11:50,403,707...50,443,224
Ensembl chr11:50,398,349...50,443,114 		JBrowse link
G Tp53 tumor protein p53 ISO ClinVar Annotator: match by term: Adenocarcinoma of prostate
ClinVar Annotator: match by term: Prostate adenocarcinoma 		ClinVar PMID:1565143 PMID:1565144 PMID:11370630 PMID:12826609 PMID:19468865 More... NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19154
    disease of cellular proliferation 7901
      cancer 5731
        cell type cancer 3786
          carcinoma 3274
            adenocarcinoma 1700
              prostate adenocarcinoma 51
                lymphoepithelioma-like acinar prostate adenocarcinoma 0
                prostate colloid adenocarcinoma 0
                prostate signet ring cell adenocarcinoma 0
                prostatic acinar adenocarcinoma 0
Path 2
Term Annotations click to browse term
  disease 19154
    disease of anatomical entity 18461
      Urogenital Diseases 5239
        Urogenital Neoplasms 2350
          reproductive system neoplasm 1445
            reproductive organ cancer 1430
              male reproductive organ cancer 832
                prostate cancer 828
                  prostate carcinoma 146
                    prostate adenocarcinoma 51
                      lymphoepithelioma-like acinar prostate adenocarcinoma 0
                      prostate colloid adenocarcinoma 0
                      prostate signet ring cell adenocarcinoma 0
                      prostatic acinar adenocarcinoma 0
paths to the root